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3. Relieving laryngopharingeral reflux (RELIEF) survey in otolaryngology - II the viewpoint of the patient

Author

Gelardi, M., Silvestrf, M., Ciprandp, G., Aielli, F., Alessandrini, P., Allosso, G., Angelillo, S., Anni, A., Antoniacomi, G., Aragona, S. E., Armone Caruso, A., Asprea, F., Azzaro, R., Balata, G., Bellini, C., DI BENEDETTO, Daniela, Bernardi, R., Buccolieri, M., Caligo, G., Campobasso, G., Canevari, F. R., Cantaffa, A., Capone, A., Carboni, S., Castagna, G., Castellani, C., Clemente, I., Cordier, A., Cossu, D., Costanzo, M., Cugno Garrano, A., Cupido, G., Danteo, M., De Luca, C., Degli Innocenti, M., Dei, A., Denuli, G., Di Bartolo, L., Dolores, A., Falcetti, S., Falciglia, AURORA MARIA ROSARIA, Fera, G., Ferraro, G., Fini, O., Giangregorio, F., Grazioli, F., Grillo, C., Guiso, M. L., Ianniello, F., Lerace, M., Ingria, F., La Mantia, I., La Pietra, G., Lambertoni, C., Lauletta, R., Lazzoni, D., Leo, S., Leone, M., Lo Iacono, Y., Maio, M., Mangiatordi, F. G., Maniscalco, F., Matricciani, A., Mirra, N., Montanaro, S. C., Montesi, P., Moro, D., Muiit, F., Mure, C., Nacci, A., Nipo, Tarsia, Pace, Annamaria, Panetti, G., Paoletti, M., Pasquarella, G., Pedrotti, I., Pellegrino, A., Petrone, D., Pinto, P., Pizzolante, M. C., Pollastrini, L., Poma, S., Quaranta, N., Reale, G., Rigo, S., Scarpa, A., Scelsi, F., Sellari, L., Serraino, E. G., Spano', Piero Giovanni Maria, Stufano, V., Tomacelli, G., Tombolini, A., and Zirone, A.

Published
2018

4. Prima dimostrazione di efficacia di un colluttorio a base di ketoprofene sale di lisina nelle flogosi acute del cavo faringeo

Author

Passali, D, Volontè, M, Livi, W, Bellussi, L, Marcocci, A, Mezzedimi, C, Mora, E, Ottoboni, S, Cassano, P, Gelardi, M, Villari, G, Califano, L, D'Avenia, E, De Benedetto, M, Castellano, L, Russolo, M, Tirelli, G, Rinaldi Ceroni, A, Sorrenti, G, Mira, E, De Paoli, F, Moratti, M, Moratti, G, Redaelli, G, Narducci, E, Pallestrini, E, Caligo, G, Staffieri, A, Bottin, R, Galletti, C, Galletti, B, Muscianisi, F, Fibbi, A, Presta, A, Alicandri Ciuffelli, C, Dragoni, L, Puxeddu, P, Puxeddu, R, Ferrara, P, Pastorello, T, Cappellini, F, Borri, G, Iengo, M, De Clemente, M, Cortesina, G, Gervaso, Cf, Perfumo, G, Righi, S, Sartoris, A, Vico, F, Antonelli, Ar, REDAELLI DE ZINIS, Luca Oscar, and Bignamini, Aa

Published
2000

5. Prime evidenze di efficacia e tollerabilità di un colluttorio a base di ketoprofene sale di lisina nelle flogosi acute del cavo faringeo: studio randomizzato versus benzidamina

Author

Bellussi, L, Volontè, M, Livi, W, Passali, D, Marcocci, A, Mezzedimi, C, Mora, E, Ottoboni, S, Cassano, P, Gelardi, M, Villari, G, Califano, L, D'Avenia, E, De Benedetto, M, Castellano, L, Russolo, M, Tirelli, G, Rinaldi Ceroni, A, Sorrenti, G, Mira, E, De Paoli, F, Moratti, M, Moratti, G, Redaelli, G, Narducci, E, Pallestrini, E, Caligo, G, Staffieri, A, Bottin, R, Galletti, C, Galletti, B, Muscianisi, F, Fibbi, A, Presta, A, Alicandri Ciuffelli, C, Dragoni, L, Puxeddu, P, Puxeddu, R, Ferrara, P, Pastorello, T, Cappellini, F, Borri, G, Iengo, M, De Clemente, M, Cortesina, G, Gervaso, Cf, Perfumo, G, Righi, S, Sartoris, A, Vico, F, Antonelli, Ar, REDAELLI DE ZINIS, Luca Oscar, and Bignamini, Aa

Published
2000

7. Nasal endoscopy in asthmatic children: clinical role in the diagnosis of rhinosinusitis

Author

Ameli, F., Castelnuovo, P., Pagella, F., Caligo, G., Cerniglia, M., Delù, G., Tosca, M. A., GIAN LUIGI MARSEGLIA, and Ciprandi, G.

Subjects
Male, Adolescent, Child, Preschool, Adenoids, Humans, Endoscopy, Female, Nasal Cavity, Sinusitis, Child, Asthma, Rhinitis
Abstract

The aim of the study was to determine the role of rigid nasal endoscopy in the diagnosis of rhinosinusitis and adenoiditis in asthmatic children. Hundred-forty-five asthmatic children (aged 2-15 years) with recurrent upper respiratory symptoms were evaluated with complete ENT examination and nasal endoscopy by rigid endoscope during local anaesthesia. A step by step endoscopic procedure is described. Endoscopy was successfully performed in 128 patients (88.3%). Purulent rhinosinusitis was diagnosed in 61 subjects (47.6%) and adenoiditis in 45 subjects (35.1%). Rhinosinusitis was associated with adenoiditis in 35 subjects (27.3%), more frequently in younger children (i.e. 2-5 years). Nasal bacteria occurred in 90% of rhinosinusitis patients. Numerous anatomical anomalies were identified. Endoscopy of nasal cavity and rhinopharynx is less traumatic and more readily accepted than other methods. Nasal endoscopy may be proposed as an appropriate routine diagnostic tool in children since it is well tolerated, easily and quickly performed, cost-efficient, and useful in diagnosing rhinosinusitis.

8. Probiotics in the add-on treatment of pharyngotonsillitis: A clinical experience

Author

La Mantia, I., Gelardi, M., Drago, L., Aragona, S. E., Cupido, G., Vicini, C., Berardi, C., Albanese, G., Anni, A., Antoniacomi, G., Artoni, S., Asprella, G., Azzaro, R., Azzolin, A., Balduzzi, A., Barbarino, I., Bertetto, B. I., Bianchi, A., Bianco, N., Bonanno, A., Bordonaro, C., Brindisi, A. M., Bucolo, S., Bulzomì, A. G., Caligo, G., Capaccio, P., Capelli, M., Capone, A., Carboni, S., Carluccio, G., Casaula, M., Cassano, M., Cavaliere, M., Ciabattoni, A., Conti, A., Cordier, A., Cortellessa, F., Costanzo, M., Cupido, F., D’ascanio, L., Danza, C., D’auria, C., Ciccio, M., Luca, C., D’emila, M., Dessi, R., Di Lullo, A., D’urso, M., Falcetti, S., Falciglia, R., Fera, G., Ferrari, G., Ferraro, S. M., Fini, O., Fiorella, M., Floriddia, A., Asprea, F., Fusco, C., Fuson, R., Gallo, A., Gambardella, T., Gambardella, G., Giangregorio, F., Gramellini, G., Ierace, M., Ingria, F., La Paglia, A., Lanza, L., Lauletta, R., Lavazza, P., Leone, M., Lovotti, P., Paolo Luperto, Maniscalco, F., Marincolo, I., Martone, R., Melis, A., Messina, A., Milone, V., Mirra, N., Montanaro, S. C., Muià, F., Nacci, A., Nardello, E., Paderno, L., Padovani, D., Palma, A., Paoletti, M., Pedrotti, I., Petrillo, F., Piccolo, M., Pinto, P., Policarpo, M., Raguso, M., Ranieri, A., Romano, G., Rondinelli, M., Russo, C., Di Santillo, L. S., Sequino, G., Serraino, E. M., Spahiu, I., Spanò, G., Stabile, C., Stagni, G., Stellin, M., Tassi, S., Tomacelli, G., Tombolini, A., Valenzise, V., and Zirone, A.

9. Probiotics in the add-on treatment of laryngotracheitis: A clinical experience

Author

La Mantia, I., Gelardi, M., Drago, L., Salvatore Emanuele Aragona, Cupido, G., Vicini, C., Berardi, C., Ciprandi, G., Albanese, G., Anni, A., Antoniacomi, G., Artoni, S., Asprella, G., Azzaro, R., Azzolin, A., Balduzzi, A., Barbarino, I., Bertetto, B. I., Bianchi, A., Bianco, N., Bonanno, A., Bordonaro, C., Brindisi, A. M., Bucolo, S., Bulzomi, A. G., Caligo, G., Capaccio, P., Capelli, M., Capone, A., Carboni, S., Carluccio, G., Casaula, M., Cassano, M., Cavaliere, M., Ciabattoni, A., Conti, A., Cordier, A., Cortellessa, F., Costanzo, M., Cupido, F., D’ascanio, L., Danza, C., D’auria, C., Ciccio, M., Luca, C., D’emila, M., Dessi, R., Di Lullo, A., D’urso, M., Falcetti, S., Falciglia, R., Fera, G., Ferrari, G., Ferraro, S. M., Fini, O., Fiorella, M., Floriddia, A., Asprea, F., Fusco, C., Fuson, R., Gallo, A., Gambardella, T., Gambardella, G., Giangregorio, F., Gramellini, G., Ierace, M., Ingria, F., La Paglia, A., Lanza, L., Lauletta, R., Lavazza, P., Leone, M., Lovotti, P., Luperto, P., Maniscalco, F., Marincolo, I., Martone, R., Melis, A., Messina, A., Milone, V., Mirra, N., Montanaro, S. C., Muià, F., Nacci, A., Nardello, E., Paderno, L., Padovani, D., Palma, A., Paoletti, M., Pedrotti, I., Petrillo, F., Piccolo, M., Pinto, P., Policarpo, M., Raguso, M., Ranieri, A., Romano, G., Rondinelli, M., Russo, C., Di Santillo, L. S., Sequino, G., Serraino, E. M., Spahiu, I., Spano, G., Stabile, C., Stagni, G., Stellin, M., Tassi, S., Tomacelli, G., Tombolini, A., Valenzise, V., and Zirone, A.

10. Probiotics in the add-on treatment of otitis media in clinical practice

Author

Gelardi, M., La Mantia, I., Drago, L., Meroni, G., Salvatore Emanuele Aragona, Cupido, G., Vicini, C., Berardi, C., Ciprandi, G., Albanese, G., Anni, A., Antoniacomi, G., Artoni, S., Asprella, G., Azzaro, R., Azzolin, A., Balduzzi, A., Barbarino, I., Bertetto, B. I., Bianchi, A., Bianco, N., Bonanno, A., Bordonaro, C., Brindisi, A. M., Bucolo, S., Bulzomì, A. G., Caligo, G., Capaccio, P., Capelli, M., Capone, A., Carboni, S., Carluccio, G., Casaula, M., Cassano, M., Cavaliere, M., Ciabattoni, A., Conti, A., Cordier, A., Cortellessa, F., Costanzo, M., Cupido, F., D’ascanio, L., Danza, C., D’auria, C., Ciccio, M., Luca, C., D’emila, M., Dessi, R., Di Lullo, A., D’urso, M., Falcetti, S., Falciglia, R., Fera, G., Ferrari, G., Ferraro, S. M., Fini, O., Fiorella, M., Floriddia, A., Asprea, F., Fusco, C., Fuson, R., Gallo, A., Gambardella, T., Gambardella, G., Giangregorio, F., Gramellini, G., Ierace, M., Ingria, F., La Paglia, A., Lanza, L., Lauletta, R., Lavazza, P., Leone, M., Lovotti, P., Luperto, P., Maniscalco, F., Marincolo, I., Martone, R., Melis, A., Messina, A., Milone, V., Mirra, N., Montanaro, S. C., Muià, F., Nacci, A., Nardello, E., Paderno, L., Padovani, D., Palma, A., Paoletti, M., Pedrotti, I., Petrillo, F., Piccolo, M., Pinto, P., Policarpo, M., Raguso, M., Ranieri, A., Romano, G., Rondinelli, M., Russo, C., Di Santillo, L. S., Sequino, G., Serraino, E. M., Spahiu, I., Spanò, G., Stabile, C., Stagni, G., Stellin, M., Tassi, S., Tomacelli, G., Tombolini, A., Valenzise, V., Zirone, A., Gelardi, M., Mantia, La, Drago, I., Meroni, L., Aragona, G., Cupido, S. E., Vicini, G., Berardi, C., Ciprandi, C., Albanese, G., Anni, G., Antoniacomi, A., Artoni, G., Asprella, S., Azzaro, G., Azzolin, R., Balduzzi, A., Barbarino, A., Berardi, I., Bertetto, C., Bianchi, B. I., Bianco, A., Bonanno, N., Bordonaro, A., Brindisi, C., Bucolo, A. M., Bulzomì, S., Caligo, A. G., Capaccio, G., Capelli, P., Capone, M., Carboni, A., Carluccio, S., Casaula, G., Cassano, M., Cavaliere, M., Ciabattoni, M., Conti, A., Cordier, A., Cortellessa, A., Costanzo, F., Cupido, M., D’Ascanio, F., Danza, L., D’Auria, C., Ciccio, De, Luca, De, D’Emila, C., Dessi, M., Lullo, Di, D’Urso, A., Falcetti, M., Falciglia, S., Fera, R., Ferrari, G., Ferraro, G., Fini, S. M., Fiorella, O., Floriddia, M., Asprea, A., Fusco, F., Fuson, C., Gallo, R., Gambardella, A., Gambardella, T., Giangregorio, G., Gramellini, F., Ierace, G., Ingria, M., Paglia, La, Lanza, A., Lauletta, L., Lavazza, R., Leone, P., Lovotti, M., Luperto, P., Maniscalco, P., Marincolo, F., Martone, I., Melis, R., Messina, A., Milone, A., Mirra, V., Montanaro, N., Muià, S. C., Nacci, F., Nardello, A., Paderno, E., Padovani, L., Palma, D., Paoletti, A., Pedrotti, M., Petrillo, I., Piccolo, F., Pinto, M., Policarpo, P., Raguso, M., Ranieri, M., Romano, A., Rondinelli, G., Russo, M., Santillo, Di, Sequino, L. S., Serraino, G., Spahiu, E. M., Spanò, I., Stabile, G., Stagni, C., Stellin, G., Tassi, M., Tomacelli, S., Tombolini, G., Valenzise, A., and Zirone, V.

Subjects
chronic, Lactobacillu, Otitis Media, dysbiosi, Probiotics, Anti-Bacterial Agent, antibiotic therapy, acute, probiotic, Human
Abstract

Otitis media (OM) affects the middle ear and is typically characterized by earache. OM may be classified as acute (AOM) or chronic (COM), based on symptom duration. OM may be clinically suspected, but the diagnosis is usually confirmed by the otoscopy. Antibiotic therapy is frequently used in clinical practice. However, antibiotics often induce intestinal and respiratory dysbiosis associated with some clinical problems. A one-month course of a probiotic mixture (Abincol® containing Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells), was prescribed in the Group A, and was compared with no addon treatment, such as the Group B. Patients were evaluated at baseline (T0), at the end of antibiotic treatment (T1), at the end of probiotic course (T2), and at the end of 3-month follow-up (T3).

11. Probiotics in the add-on treatment of rhinosinusitis: A clinical experience

Author

La Mantia, I., Gelardi, M., Drago, L., Aragona, S. E., Cupido, G., Vicini, C., Berardi, C., Ciprandi, G., Albanese, G., Anni, A., Antoniacomi, G., Artoni, S., Asprella, G., Azzaro, R., Azzolin, A., Balduzzi, A., Barbarino, I., Bertetto, B. I., Bianchi, A., Bianco, N., Bonanno, A., Bordonaro, C., Brindisi, A. M., Bucolo, S., Bulzomi, A. G., Caligo, G., Capaccio, P., Capelli, M., Capone, A., Carboni, S., Carluccio, G., Casaula, M., Cassano, M., Cavaliere, M., Ciabattoni, A., Conti, A., Cordier, A., Cortellessa, F., Costanzo, M., Cupido, F., D’ascanio, L., Danza, C., D’auria, C., Ciccio, M., Luca, C., D’emila, M., Dessi, R., Di Lullo, A., D’urso, M., Falcetti, S., Falciglia, R., Fera, G., Ferrari, G., Ferraro, S. M., Fini, O., Fiorella, M., Floriddia, A., Asprea, F., Fusco, C., Fuson, R., Gallo, A., Gambardella, T., Gambardella, G., Giangregorio, F., Gramellini, G., Ierace, M., Ingria, F., La Paglia, A., Lanza, L., Lauletta, R., Lavazza, P., Leone, M., Lovotti, P., Paolo Luperto, Maniscalco, F., Marincolo, I., Martone, R., Melis, A., Messina, A., Milone, V., Mirra, N., Montanaro, S. C., Muià, F., Nacci, A., Nardello, E., Paderno, L., Padovani, D., Palma, A., Paoletti, M., Pedrotti, I., Petrillo, F., Piccolo, M., Pinto, P., Policarpo, M., Raguso, M., Ranieri, A., Romano, G., Rondinelli, M., Russo, C., Di Santillo, L. S., Sequino, G., Serraino, E. M., Spahiu, I., Spano, G., Stabile, C., Stagni, G., Stellin, M., Tassi, S., Tomacelli, G., Tombolini, A., Valenzise, V., and Zirone, A.

12. Correlation between the reflux finding score and the reflux symptom index in patients with laryngopharyngeal reflux

Author

Gelardi, M., Silvestrf, M., Ciprandp, G., Aielli, F., Alessandrini, P., Allosso, G., Angelillo, S., Anni, A., Antoniacomi, G., Salvatore Emanuele Aragona, Armone Caruso, A., Asprea, F., Azzaro, R., Balata, G., Bellini, C., Benedetto, D., Bernardi, R., Buccolieri, M., Caligo, G., Campobasso, G., Canevari, F. R., Cantaffa, A., Capone, A., Carboni, S., Castagna, G., Castellani, C., Clemente, I., Cordier, A., Cossu, D., Costanzo, M., Cugno Garrano, A., Cupido, G., Danteo, M., Luca, C., Degli Innocenti, M., Dei, A., Denuli, G., Di Bartolo, L., Dolores, A., Falcetti, S., Falciglia, R., Fera, G., Ferraro, G., Fini, O., Giangregorio, F., Grazioli, F., Grillo, C., Guiso, M. L., Ianniello, F., Lerace, M., Ingria, F., La Mantia, I., La Pietra, G., Lambertoni, C., Lauletta, R., Lazzoni, D., Leo, S., Leone, M., Lo Iacono, Y., Maio, M., Mangiatordi, F. G., Maniscalco, F., Matricciani, A., Mirra, N., Montanaro, S. C., Montesi, P., Moro, D., Muiit, F., Mure, C., Nacci, A., Nipo, T., Pace, A., Panetti, G., Paoletti, M., Pasquarella, G., Pedrotti, I., Pellegrino, A., Petrone, D., Pinto, P., Pizzolante, M. C., Pollastrini, L., Poma, S., Quaranta, N., Reale, G., Rigo, S., Scarpa, A., Scelsi, F., Sellari, L., Serraino, E. G., Spano, G., Stufano, V., Tomacelli, G., Tombolini, A., and Zirone, A.

Subjects
Cohort Studies, gastric reflux, GERD, laryngo-pharyngeal reflux, Maria!®, Italy, Laryngoscopy, Laryngopharyngeal Reflux, Humans, gastric reflux, GERD, laryngo-pharyngeal reflux, Maria!, Maria!
Abstract

LaryngoPharyngeal Reflux (LPR) is characterized by symptoms, signs, and/or tissue damage resulting from the aggression of the gastrointestinal contents in the upper airways. The Reflux Finding Score (RFS) assesses the laryngeal signs through laryngoscopy. The Reflux Symptom Index (RSI) scores the LPR symptoms. The objective of this real-world study was to compare RFS with RSI in a cohort of Italian LPR patients. Globally, 3932 patients with LPR were evaluated and RFS and RSI were assessed in all subjects. A moderate correlation was found between RSI and RFS (r=0.484, p0.0001). In conclusion, the RSI and RFS can easily be included in the LPR work-up as objective and consistent parameters, with low cost and high practicality. Based on these clinical outcomes, the specialist can easily use these tests in clinical practice.

13. Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: a pilot study.

Author

Ciprandi G, Tosca MA, Milanese M, Caligo G, and Ricca V

Subjects
Child, Child, Preschool, Cytokines analysis, Female, Humans, Hypersensitivity complications, Immunotherapy methods, Male, Nasal Lavage Fluid chemistry, Pilot Projects, Recurrence, Respiratory Tract Infections complications, Adjuvants, Immunologic physiology, Bacillus immunology, Hypersensitivity immunology, Respiratory Tract Infections immunology
Abstract

Respiratory infections are very frequent in children. Bacillus clausii has been demonstrated to exert some immunomodulatory activities and to be safe. We conducted a study to investigate whether B. clausii administration in allergic children with recurrent respiratory infections might modulate cytokine pattern. Ten children (mean age 4.4 yr) attending the nursery school were enrolled at the end of school year (i.e. in the summer). Bacillus clausii spores (Enterogermina): 2 billion spores per vial) were administered at the dosage schedule of two vials a day for 4 wk. A panel of cytokines, including interleukin (IL)-1, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, and tumor necrosis factor (TNF)-alpha, was measured by immunoassay in the fluid recovered from nasal lavage, performed before and after the treatment. Bacillus clausii treatment induced a significant decrease of IL-4 levels (p < 0.01) and a significant increase of IFN-gamma (p < 0.05), IL-12 (p < 0.001), TGF-beta (p < 0.05), and IL-10 (p < 0.05) levels. Other cytokines were not significantly modified. In conclusion, this study shows that the B. clausii may exert immunomodulating activity by affecting cytokine pattern at nasal level in allergic children with recurrent respiratory infections.

Published
2004
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14. Nasal endoscopy in asthmatic children: clinical role in the diagnosis of rhinosinusitis.

Author

Ameli F, Castelnuovo P, Pagella F, Caligo G, Cerniglia M, Delù G, Tosca MA, Marseglia GL, and Ciprandi G

Subjects
Adenoids pathology, Adolescent, Child, Child, Preschool, Female, Humans, Male, Nasal Cavity, Rhinitis complications, Sinusitis complications, Asthma complications, Endoscopy, Rhinitis diagnosis, Sinusitis diagnosis
Abstract

The aim of the study was to determine the role of rigid nasal endoscopy in the diagnosis of rhinosinusitis and adenoiditis in asthmatic children. Hundred-forty-five asthmatic children (aged 2-15 years) with recurrent upper respiratory symptoms were evaluated with complete ENT examination and nasal endoscopy by rigid endoscope during local anaesthesia. A step by step endoscopic procedure is described. Endoscopy was successfully performed in 128 patients (88.3%). Purulent rhinosinusitis was diagnosed in 61 subjects (47.6%) and adenoiditis in 45 subjects (35.1%). Rhinosinusitis was associated with adenoiditis in 35 subjects (27.3%), more frequently in younger children (i.e. 2-5 years). Nasal bacteria occurred in 90% of rhinosinusitis patients. Numerous anatomical anomalies were identified. Endoscopy of nasal cavity and rhinopharynx is less traumatic and more readily accepted than other methods. Nasal endoscopy may be proposed as an appropriate routine diagnostic tool in children since it is well tolerated, easily and quickly performed, cost-efficient, and useful in diagnosing rhinosinusitis.

Published
2004

15. Improvement of clinical and immunopathologic parameters in asthmatic children treated for concomitant chronic rhinosinusitis.

Author

Tosca MA, Cosentino C, Pallestrini E, Caligo G, Milanese M, and Ciprandi G

Subjects
Asthma drug therapy, Child, Child, Preschool, Endoscopy, Female, Fluticasone, Forced Expiratory Volume, Humans, Interferon-gamma metabolism, Interleukin-4 metabolism, Male, Neutrophils metabolism, Pregnenediones therapeutic use, Rhinitis, Allergic, Perennial drug therapy, Sinusitis drug therapy, Amoxicillin-Potassium Clavulanate Combination therapeutic use, Androstadienes therapeutic use, Anti-Inflammatory Agents therapeutic use, Asthma complications, Drug Therapy, Combination therapeutic use, Rhinitis, Allergic, Perennial complications, Sinusitis complications
Abstract

Background: Chronic rhinosinusitis is frequently associated with asthma. A Th2 cytokine pattern has been recently reported in chronic rhinosinusitis in asthmatic children., Objective: To evaluate the effects of treating concomitant chronic rhinosinusitis on respiratory symptoms and function and immunopathological parameters in asthmatic children., Methods: Eighteen children with moderate asthma (age range, 5 to 12 years) poorly controlled by high doses of inhaled corticosteroids and chronic rhinosinusitis were evaluated for symptoms, spirometry, and inflammation at baseline, after treatment, and 1 month after suspension of treatment. All of the children were treated with a combination of amoxicillin and clavulanate (20 mg/kg twice daily) and fluticasone propionate aqueous nasal spray (100 microg/d) for 14 days. A short course of oral corticosteroids was also prescribed (deflazacort, 1 mg/kg daily for 2 days, 0.5 mg/kg daily for 4 days, and 0.25 mg/kg daily for 4 days). Rhinosinusal lavage for cytokine measurements and a nasal scraping for cytologic analysis were performed in all patients before and after medical treatment., Results: A negative endoscopy result was demonstrated in 15 children after treatment. Symptoms and respiratory function significantly improved after treatment and 1 month later; 8 children had intermittent asthma and 10 had mild asthma. A significant reduction of inflammatory cell numbers was detected in all asthmatic children. Interleukin 4 levels significantly decreased (P < 0.001), whereas interferon-y levels increased (P < 0.001)., Conclusion: Treatment of chronic rhinosinusitis is able to improve symptoms and respiratory function in asthmatic children, reducing inflammatory cells and reversing the cytokine pattern from a Th2 toward a Th1 profile.

Published
2003
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16. [Wegener's and Stewart's granulomatosis: a case report of Stewart's granulomatosis].

Author

Castello E, Caligo G, Ravetti JL, and Pallestrini EA

Subjects
Anti-Inflammatory Agents therapeutic use, Biopsy, Diagnosis, Differential, Female, Granuloma drug therapy, Granuloma surgery, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Middle Aged, Nasal Mucosa pathology, Paranasal Sinus Diseases drug therapy, Paranasal Sinus Diseases surgery, Steroids, Granuloma pathology, Granulomatosis with Polyangiitis diagnosis, Paranasal Sinus Diseases pathology
Abstract

Wegener's and Stewart's diseases are two rare pathologies of unknown origin; both can cause disruptive facial lesions. Wegener's disease is a systemic pathology and generally involves the kidneys and lungs. Granulomatosis lesions are characterized by the necrotizing vasculitis involving the small vessels. From a diagnostic point of view the systemic features of Wegener's disease and the specific immunological findings (i.e. IgG autoantibodies vs. monocyte and neutrophil cytoplasm) make it possible to diagnose the disease precisely. Stewart's disease can be differentiated from Wegener's disease by the absence of any systemic lesions and the lack of necrotizing vasculitis. Pathogenesis of the disease is still unknown although immunohistochemical findings indicate that it is related to extranodal Tcell lymphomas. Stewart's disease is very aggressive with massive destruction of the midface tissues and prognosis is very poor (from a few months to 23 years). Surgery is generally ineffective in such disorders. The treatment for Wegener's disease includes the use of systemic steroids, immunosuppressive drugs and the sulfametoxazole-thrimethoprime association while radiotherapy associated with chemotherapy appears most effective in Stewart's disease. The authors describe a case of Stewart's disease prevalently involving the nasal cavities, ethmoid and paranasal sinuses. Diagnosis was made on the basis of immunohistochemical, histomorphological and immunological data. Treatment--based initially on systemic steroids with the association thrimethoprimsulfometoxazole--induced significant disease remission. Subsequent use of cytostatic drugs has made it possible to control the disease progression to date.

Published
1998

17. [Case report: pleomorphic adenoma of the lateral nasal wall].

Author

Castello E, Caligo G, and Pallestrini EA

Subjects
Adenoma, Pleomorphic diagnostic imaging, Adenoma, Pleomorphic surgery, Humans, Male, Middle Aged, Nasal Cavity diagnostic imaging, Nasal Cavity surgery, Nose Neoplasms diagnostic imaging, Nose Neoplasms surgery, Tomography, X-Ray Computed, Adenoma, Pleomorphic pathology, Nasal Cavity pathology, Nose Neoplasms pathology
Abstract

Pleomorphic adenoma is a tumor which most often originates from one of the major salivary glands; it is rarely located in the lacrymal glands and it is highly exceptional in the nasal cavity. Cases of pleomorphic adenoma in the nasal cavity have been described by Spiro (40 cases), Compagno and Wong (40 cases) and Suzuki et al. (41 cases). This type of tumor generally originates from the septal mucosa even though the seromucosal glands are mostly located in the lateral nasal wall. This pathology is more frequently found in females. The clinical signs of this tumor are non specific, slow unilateral nasal occlusion, rhinorrhea and, at times, epistaxis. Evolution is generally local although locoregional and distant metastases have been described in the literature. This sort of tumor has no specific appearance and thus diagnosis is based on histology. Indeed, microscopically nasal pleomorphic adenoma differs from salivary gland adenoma for the predominance of the cellular component over the connective component. The epithelial cells are small, oval-shaped and often arranged in cordons; they are sometimes organized in small acinous structures. The connective component can be mixoid, condroid or collagenous; follicles with squamous metaplasia and mitosis are rare. Histologically differentiating this disorder from olfactory esthesione-uroblastoma can prove difficult; the lack of extra cellular neurifibrillar structures, neurotubules and neurosecretory granules in nasal pleomorphic adenoma are the main distinguishing criteria. The present work reports a case of a 45-year-old man who had suffered of an increasing unilateral nasal obstruction from 1 year. Endoscopic examination showed a smooth surface neoplasm involving the entire nasal cavity. CT scan showed the deformation of the medial bone wall of the maxillary sinus and of the ethmoid although without any osteolysis. Median maxillectomy surgical exeresis of the neoplasm was performed with the facial degloving technique. Histology revealed a 5 cm pleomorphic adenoma originating from the lateral nasal wall. This origin is extremely rare because this tumor generally originates in the nasal septum. Immunohistochemical stains proved positive for epithelial membrane antigen (MNF 116), for myoepithelial cells (PS100) and for stromal cells (Vimentine) with the epithelial elements predominating. After 9 months of follow-up the patient is still disease free.

Published
1996

18. [The randomized double-blind study of postoperative tonsillectomy pain control by muscle relaxants].

Author

Lunghi F, Caligo G, Di Franco R, Gjonovic A, Lunghi M, Ongaro L, and Sattin G

Subjects
Adolescent, Adult, Animals, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Double-Blind Method, Female, Humans, Muscle Spasticity drug therapy, Muscle Spasticity etiology, Pain Measurement, Pain, Postoperative complications, Parasympatholytics adverse effects, Placebos therapeutic use, Rabbits, Surveys and Questionnaires, Baclofen therapeutic use, Pain, Postoperative drug therapy, Parasympatholytics therapeutic use, Tonsillectomy
Abstract

Tonsillectomy is accompanied by 7 to 14 days of pain. We entered 36 patients into a double blind placebo controlled study with dantrolene sodium, lioresal to evaluate modification of tonsillectomy pain and analgesic requirements after tonsillectomy. Patients were randomly assigned either dantrolene or lioresal or placebo orally four times a day for 5 days postoperatively. On a standardized questionnaire the patients recorded pain, activity level, analgesic requirements and side effects. We conclude that there is no significant differences in subjective pain or analgesic requirements between 3 groups. The muscle spasm is not the only factor of tonsillectomy pain. There is the association of other factors: nerve endings, individual sensitivity, local products of inflammation. In conclusion to control tonsillectomy pain we must use drugs with different action.

Published
1993

19. [Mycosis of the paranasal sinuses: a report of 4 cases].

Author

Lunghi F, Borruso F, Caligo G, DiFranco R, Lunghi M, Rimini A, and Spinato R

Subjects
Adult, Aged, Aspergillosis diagnosis, Female, Humans, Male, Maxillary Sinus, Sphenoid Sinus, Streptococcal Infections diagnosis, Mycoses diagnosis, Paranasal Sinus Diseases diagnosis
Abstract

With recent advances in medicine, fungal diseases are not only being better under stood, but are also becoming increasingly important in the management of patients with paranasal sinus disease. Fungal sinus diseases range from allergic fungal sinusitis to invasive and fulminant fungal sinusitis. Although patients often have some predisposing factor, such as local tissue hypoxia or massive fungal ++exposure, most patients are not immuno-compromised. Invasive fungal sinusitis may be treated with the traditional Caldwell-Luc surgical technique or with newer endoscopic procedures. Fulminant fungal sinusitis generally occurs in immuno-suppressed patients and requires aggressive surgical excision and debridement as well as systemic chemotherapy, usually amphotericin B. In this article we review fungal diseases of the paranasal sinuses and present four cases of paranasal fungal sinusitis.

Published
1992

20. [Gardner's syndrome: a case report].

Author

Di Franco R, Caligo G, Corso F, Lunghi M, and Lunghi F

Subjects
Colectomy, Female, Gardner Syndrome genetics, Gardner Syndrome surgery, Humans, Mandibular Neoplasms genetics, Mandibular Neoplasms pathology, Mandibular Neoplasms surgery, Osteoma genetics, Osteoma pathology, Osteoma surgery, Pedigree, Gardner Syndrome pathology
Abstract

The Gardner syndrome (GS) is a dysplasia in which neoformations in the intestines, soft tissue and osseous tissue are associated. Since extra-intestinal manifestations, in particularly osteomas, appear promptly even in infants, and above all in the light of the possibility of malignant degeneration, the presence of mandibular osteomas indicates the necessity of carrying out investigations in order to ascertain the eventual existence of an intestinal polyposis typical of GS. This study describes a typical case of GS diagnosed merely upon suspicion of the existence of the syndrome in a patient who came to our Department with a mandibular osteoma. The study underlines the importance not only of carrying out investigations in order to ascertain the presence of GS (rectocolonoscopy), but also that of studying the relatives of the patient in light of the fact that this particular dysplasia is transmitted genetically.

Published
1992

21. [Fistula of the second branchial cleft. Radiographic and echographic findings].

Author

Falaschi F, Bagnolesi P, Papini M, Caligo G, and Chiantelli A

Subjects
Abscess etiology, Aged, Fistula complications, Fistula diagnostic imaging, Humans, Male, Pharyngeal Diseases etiology, Radiography, Skin Diseases diagnostic imaging, Branchial Region, Fistula diagnosis, Skin Diseases diagnosis, Ultrasonography
Published
1988

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