Search

Your search keyword '"Calero Acuña, Carmen"' showing total 124 results
Start Over Author "Calero Acuña, Carmen"
124 results on '"Calero Acuña, Carmen"'

2. Effectiveness and Safety of Inhaled Antibiotics in Patients With Chronic Obstructive Pulmonary Disease. A Multicentre Observational Study

Author

Rolon, Annie Navarro, Wang, Xuejie, Tapia, Alicia Marín, Rubio, Myriam Calle, Asensio, María Jesús Linares, Orbis, Iria Pérez, Olondris, Pilar Martínez, Sanz, Ascensión Hernando, Gafas, Alicia de Pablos, Royo, Margarita Marín, Peris, Selene Cuenca, Fuertes, Julia Amaranta García, Olveira, Casilda, Ramos, Guillermo Bentabol, Bou, Lirios Sacristán, Moreno, Rosa María Girón, Arguedas, Sandra Marín, Zabaleta, Raúl Moreno, Fernández, Sarai Quirós, Sarasate, Mikel, Arranz, María Victoria Leal, Pozas, Gema Castaño de las, Ávila, Nuria Bruguera, Diago, Carlos Antonio Amado, Viteri, Soledad Alonso, Cancelo, María Isabel Ramos, Rivera, Carolina Gotera, Díez, Javier de Miguel, Muñoz, Gemma Sánchez, Zapatero, Esperanza Martín, Celis, Sandra Ros, Navarro, Silvia Merlos, García, Rut Ayerbe, De la Rosa Carrillo, David, Martínez-García, Miguel Ángel, Barreiro, Esther, Tabernero Huguet, Eva, Costa Sola, Roser, García-Clemente, Marta María, Celorrio Jiménez, Nuria, Rodríguez Pons, Laura, Calero Acuña, Carmen, Rodríguez Hermosa, Juan Luís, Golpe, Rafael, Dacal Quintas, Raquel, Sánchez-Cuéllar, Silvia, Torres Arroyo, Irene, Blanco Aparicio, Marina, Almadana Pacheco, Virginia, and Miravitlles, Marc

Published
2022
Full Text
View/download PDF

6. Prepandemic viral community‐acquired pneumonia: Diagnostic sensitivity and specificity of nasopharyngeal swabs and performance of clinical severity scores

Author

Berastegui‐Cabrera, Judith, primary, Aguilar‐Guisado, Manuela, additional, Crespo‐Rivas, Juan Carlos, additional, López‐Verdugo, Macarena, additional, Merino, Laura, additional, Escoresca‐Ortega, Ana, additional, Calero‐Acuña, Carmen, additional, Carrasco‐Hernández, Laura, additional, Toral‐Marín, Javier Ignacio, additional, Abad‐Arranz, María, additional, Ramírez‐Duque, Nieves, additional, Barón‐Franco, Bosco, additional, Pachón, Jerónimo, additional, Álvarez‐Marín, Rocío, additional, and Sánchez‐Céspedes, Javier, additional

Published
2022
Full Text
View/download PDF

10. Prepandemic viral community‐acquired pneumonia: Diagnostic sensitivity and specificity of nasopharyngeal swabs and performance of clinical severity scores.

Author

Berastegui‐Cabrera, Judith, Aguilar‐Guisado, Manuela, Crespo‐Rivas, Juan Carlos, López‐Verdugo, Macarena, Merino, Laura, Escoresca‐Ortega, Ana, Calero‐Acuña, Carmen, Carrasco‐Hernández, Laura, Toral‐Marín, Javier Ignacio, Abad‐Arranz, María, Ramírez‐Duque, Nieves, Barón‐Franco, Bosco, Pachón, Jerónimo, Álvarez‐Marín, Rocío, and Sánchez‐Céspedes, Javier

Subjects
COMMUNITY-acquired pneumonia, SENSITIVITY & specificity (Statistics), LEGIONELLA pneumophila, STREPTOCOCCUS pneumoniae, BACTERIAL cultures, INFLUENZA
Abstract

The objectives of this work were to assess the diagnostic sensitivity and specificity of nasopharyngeal (NP) swabs for viral community‐acquired pneumonia (CAP) and the performance of pneumonia severity index (PSI) and CURB‐65 severity scores in the viral CAP in adults. A prospective observational cohort study of consecutive 341 hospitalized adults with CAP was performed between January 2018 and March 2020. Demographics, comorbidities, symptoms/signs, analytical data, severity scores, antimicrobials, and outcomes were recorded. Blood, NP swabs, sputum, and urine samples were collected at admission and assayed by multiplex real time‐PCR, bacterial cultures, and Streptococcus pneumoniae and Legionella pneumophila antigens detection, to determine the etiologies and quantify the viral load. The etiology was identified in 174 (51.0%) patients, and in 85 (24.9%) it was viral, the most frequent rhinovirus and influenza virus. The sensitivity of viral detection in sputum (50.7%) was higher than in NP swabs (20.9%). Compared with sputum, the positive predictive value and specificity of NP swabs for viral diagnosis were 95.8% and 96.9%, respectively. Performance of PSI and CURB‐65 scores in all CAP with etiologic diagnosis were as expected, with mortality associated with higher values, but they were not associated with mortality in patients with viral pneumonia. NP swabs have lower sensitivity but high specificity for the diagnosis of viral CAP in adults compared with sputum, reinforcing the use NP swabs for the diagnostic etiology work‐up. The PSI and CURB‐65 scores did not predict mortality in the viral CAP, suggesting that they need to be updated scores based on the identification of the etiological agent. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

11. Effectiveness and Safety of Inhaled Antibiotics in Patients With Chronic Obstructive Pulmonary Disease. A Multicentre Observational Study

Author

De la Rosa Carrillo, David, primary, Martínez-García, Miguel Ángel, additional, Barreiro, Esther, additional, Tabernero Huguet, Eva, additional, Costa Sola, Roser, additional, García-Clemente, Marta María, additional, Celorrio Jiménez, Nuria, additional, Rodríguez Pons, Laura, additional, Calero Acuña, Carmen, additional, Rodríguez Hermosa, Juan Luís, additional, Golpe, Rafael, additional, Dacal Quintas, Raquel, additional, Sánchez-Cuéllar, Silvia, additional, Torres Arroyo, Irene, additional, Blanco Aparicio, Marina, additional, Almadana Pacheco, Virginia, additional, Miravitlles, Marc, additional, Rolon, Annie Navarro, additional, Wang, Xuejie, additional, Tapia, Alicia Marín, additional, Rubio, Myriam Calle, additional, Asensio, María Jesús Linares, additional, Orbis, Iria Pérez, additional, Olondris, Pilar Martínez, additional, Sanz, Ascensión Hernando, additional, Gafas, Alicia de Pablos, additional, Royo, Margarita Marín, additional, Peris, Selene Cuenca, additional, Fuertes, Julia Amaranta García, additional, Olveira, Casilda, additional, Ramos, Guillermo Bentabol, additional, Bou, Lirios Sacristán, additional, Moreno, Rosa María Girón, additional, Arguedas, Sandra Marín, additional, Zabaleta, Raúl Moreno, additional, Fernández, Sarai Quirós, additional, Sarasate, Mikel, additional, Arranz, María Victoria Leal, additional, Pozas, Gema Castaño de las, additional, Ávila, Nuria Bruguera, additional, Diago, Carlos Antonio Amado, additional, Viteri, Soledad Alonso, additional, Cancelo, María Isabel Ramos, additional, Rivera, Carolina Gotera, additional, Díez, Javier de Miguel, additional, Muñoz, Gemma Sánchez, additional, Zapatero, Esperanza Martín, additional, Celis, Sandra Ros, additional, Navarro, Silvia Merlos, additional, and García, Rut Ayerbe, additional

Published
2022
Full Text
View/download PDF

14. Differences in Overexpression of Hypoxia-induced Transcription Factors and Associated Biomarkers in Three Different Types of Chronic Hypoxia

Author

Asensio-Cruz, Maria Isabel, primary, Calero-Acuña, Carmen, additional, Arellano-Orden, Elena, additional, Sánchez-López, Verónica, additional, Caballero-Eraso, Candelaria, additional, Cejudo, Pilar, additional, Lopez-Villalobos, Jose Luis, additional, Lopez-Campos, Jose Luis, additional, Ortega-Ruiz, Francisco, additional, and Sánchez-Armengol, Ángeles, additional

Published
2021
Full Text
View/download PDF

20. Author_Response_1 – Supplemental material for Triple therapy for COPD: a crude analysis from a systematic review of the evidence

Author

Lopez-Campos, Jose Luis, Carrasco-Hernandez, Laura, Quintana-Gallego, Esther, Calero-Acuña, Carmen, Márquez-Martín, Eduardo, Ortega-Ruiz, Francisco, and Soriano, Joan B.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, Author_Response_1 for Triple therapy for COPD: a crude analysis from a systematic review of the evidence by Jose Luis Lopez-Campos, Laura Carrasco-Hernandez, Esther Quintana-Gallego, Carmen Calero-Acuña, Eduardo Márquez-Martín, Francisco Ortega-Ruiz and Joan B. Soriano in Therapeutic Advances in Respiratory Disease

Published
2019
Full Text
View/download PDF

21. Reviewer_2_v.2 – Supplemental material for Triple therapy for COPD: a crude analysis from a systematic review of the evidence

Author

Lopez-Campos, Jose Luis, Carrasco-Hernandez, Laura, Quintana-Gallego, Esther, Calero-Acuña, Carmen, Márquez-Martín, Eduardo, Ortega-Ruiz, Francisco, and Soriano, Joan B.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, Reviewer_2_v.2 for Triple therapy for COPD: a crude analysis from a systematic review of the evidence by Jose Luis Lopez-Campos, Laura Carrasco-Hernandez, Esther Quintana-Gallego, Carmen Calero-Acuña, Eduardo Márquez-Martín, Francisco Ortega-Ruiz and Joan B. Soriano in Therapeutic Advances in Respiratory Disease

Published
2019
Full Text
View/download PDF

22. Online_supplement – Supplemental material for Triple therapy for COPD: a crude analysis from a systematic review of the evidence

Author

Lopez-Campos, Jose Luis, Carrasco-Hernandez, Laura, Quintana-Gallego, Esther, Calero-Acuña, Carmen, Márquez-Martín, Eduardo, Ortega-Ruiz, Francisco, and Soriano, Joan B.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, Online_supplement for Triple therapy for COPD: a crude analysis from a systematic review of the evidence by Jose Luis Lopez-Campos, Laura Carrasco-Hernandez, Esther Quintana-Gallego, Carmen Calero-Acuña, Eduardo Márquez-Martín, Francisco Ortega-Ruiz and Joan B. Soriano in Therapeutic Advances in Respiratory Disease

Published
2019
Full Text
View/download PDF

24. Exposición laboral y a biomasa en la EPOC: resultados de un análisis transversal del estudio On-Sint

Author

López-Campos, J. L., Fernández-Villar, Alberto, Calero-Acuña, Carmen, Represas-Represas, Cristina, López-Ramírez, Cecilia, Leiro Fernández, Virginia, and Casamor, Ricard

Subjects
Epidemiology, COPD, Biomasa, Laboral, Epidemiología, Distribución geográfica, Biomass, EPOC, Geographic distribution, Occupational, respiratory tract diseases
Abstract

[Background] Although tobacco smoke is the main risk factor for chronic obstructive pulmonary disease (COPD), other inhaled toxics have also been associated with the disease. The present study analyzes data from exposure to these substances in a cohort of patients with COPD and assesses their impact on the clinical presentation of the disease., [Methods] This is a cross-sectional analysis of the Clinical presentation, diagnosis and course of chronic obstructive pulmonary disease (On-Sint) study. All patients were smokers or ex-smokers as per protocol. In addition, during the inclusion visit patients were enquired about their occupational and biomass exposure history. The clinical features of patients with and without an added risk factor to tobacco were compared and those significant were entered in a multivariate logistic regression analysis, expressed as odds ratio (OR)., [Results] The sample size was 1214 patients with COPD, of which 1012 (83.4%) had tobacco as the only risk factor and 202 (16.6%) had additional ones, mainly 174 (14.3%) with occupational gases and 32 (2.6%) with biomass exposure. The geographical distribution of this exposure showed a preference for the northern parts of the country and the East coast. The biomass exposure was rather low. Male gender (OR: 2.180), CAT score (OR: 1.036) and the use of long-term oxygen therapy (OR: 1.642) were associated with having an additional risk factor in the multivariate analysis., [Conclusions] Occupational exposures are more common than biomass in Spain. COPD caused by tobacco plus other inhalants has some differential features and a more impaired quality of life., [Introducción] Aunque el humo del tabaco es el principal factor de riesgo de la enfermedad pulmonar obstructiva crónica (EPOC), también se han relacionado con la enfermedad otros agentes tóxicos inhalados. El presente estudio analiza datos de la exposición a estas sustancias y evalúa su impacto sobre la presentación clínica de la enfermedad en una cohorte de pacientes con EPOC., [Métodos] Se trata de un análisis transversal del estudio Presentación clínica, diagnóstico y evolución de la enfermedad pulmonar obstructiva crónica (On-Sint). De conformidad con el protocolo, todos los pacientes eran fumadores o exfumadores. Durante la visita de inclusión se interrogó a los pacientes acerca de sus antecedentes de exposición laboral a tóxicos y a combustión de biomasa. Las características clínicas de los pacientes que presentaban algún factor de riesgo además del tabaco se compararon con las de los pacientes que no presentaban factores de riesgo adicionales, y los factores que indicaron ser significativos fueron incluidos en un análisis de regresión logística multivariante, expresados en oportunidades relativas (odds ratio [OR])., [Resultados] La muestra incluyó 1.214 pacientes con EPOC, en 1.012 (83,4%) de los cuales el tabaco era el único factor de riesgo. En 202 (16,6%) se constataron otros factores, en 174 (14,3%) principalmente la exposición a gases en el ámbito laboral y en 32 (2,6%) la exposición a combustión de biomasa. La distribución geográfica de esta exposición fue mayor en la zona norte y la costa este del país. La exposición a humo de biomasa fue relativamente baja. El análisis multivariante mostró asociaciones entre la presentación de un factor de riesgo adicional y el sexo masculino (OR: 2,180), la puntuación CAT (OR: 1,036) y el uso de oxigenoterapia crónica (OR: 1,642)., [Conclusiones] En España, la exposición laboral a tóxicos inhalados es más frecuente que la exposición a humo de biomasa. La EPOC causada por el tabaco y otros productos inhalados tiene algunas características diferenciales y provoca un mayor deterioro de la calidad de vida.

Published
2017

27. Seasonal variability in clinical care of COPD outpatients: results from the Andalusian COPD audit

Author

López-Campos, Jose Luis, primary, Abad-Arranz, Maria, additional, Calero-Acuña, Carmen, additional, Romero-Valero, Fernando, additional, Ayerbe-Garcia, Ruth, additional, Hidalgo-Molina, Antonio, additional, Aguilar-Pérez-Grovas, Ricardo I, additional, García-Gil, Francisco, additional, Casas-Maldonado, Francisco, additional, Caballero-Ballesteros, Laura, additional, Sánchez-Palop, María, additional, Pérez-Tejero, Dolores, additional, Segado, Alejandro, additional, Calvo-Bonachera, Jose, additional, Hernández-Sierra, Bárbara, additional, Doménech, Adolfo, additional, Arroyo-Varela, Macarena, additional, González-Vargas, Francisco, additional, and Cruz-Rueda, Juan J, additional

Published
2017
Full Text
View/download PDF

31. Determinants for changing the treatment of COPD: a regression analysis from a clinical audit

Author

Lopez-Campos, Jose Luis, primary, Abad-Arranz, Maria, additional, Calero Acuña, Carmen, additional, Romero-Valero, Fernando, additional, Ayerbe García, Ruth, additional, Hidalgo-Molina, Antonio, additional, Aguilar-Perez-Grovas, Ricardo I., additional, García-Gil, Francisco, additional, Casas-Maldonado, Francisco, additional, Caballero-Ballesteros, Laura, additional, Sanchez-Palop, Maria, additional, Perez-Tejero, Dolores, additional, Segado, Alejandro, additional, Calvo-Bonachera, Jose, additional, Hernandez-Sierra, Barbara, additional, Domenech, Adolfo, additional, Arroyo-Varela, Macarwena, additional, González Vargas, F, additional, and Cruz-Rueda, Juan Jose, additional

Published
2016
Full Text
View/download PDF

32. Cigarette Smoke Decreases the Maturation of Lung Myeloid Dendritic Cells

Author

Arellano-Orden, Elena, primary, Calero-Acuña, Carmen, additional, Moreno-Mata, Nicolás, additional, Gómez-Izquierdo, Lourdes, additional, Sánchez-López, Verónica, additional, López-Ramírez, Cecilia, additional, Tobar, Daniela, additional, López-Villalobos, José Luis, additional, Gutiérrez, Cesar, additional, Blanco-Orozco, Ana, additional, and López-Campos, José Luis, additional

Published
2016
Full Text
View/download PDF

33. Guideline Adherence in Outpatient Clinics for Chronic Obstructive Pulmonary Disease: Results from a Clinical Audit

Author

López-Campos, Jose L., primary, Abad Arranz, Maria, additional, Calero-Acuña, Carmen, additional, Romero-Valero, Fernando, additional, Ayerbe-García, Ruth, additional, Hidalgo-Molina, Antonio, additional, Aguilar-Pérez-Grovas, Ricardo I., additional, García-Gil, Francisco, additional, Casas-Maldonado, Francisco, additional, Caballero-Ballesteros, Laura, additional, Sánchez-Palop, María, additional, Pérez-Tejero, Dolores, additional, Segado, Alejandro, additional, Calvo-Bonachera, Jose, additional, Hernández-Sierra, Bárbara, additional, Doménech, Adolfo, additional, Arroyo-Varela, Macarena, additional, González-Vargas, Francisco, additional, and Cruz-Rueda, Juan J., additional

Published
2016
Full Text
View/download PDF

37. Clinical Audits in Outpatient Clinics for Chronic Obstructive Pulmonary Disease: Methodological Considerations and Workflow

Author

López-Campos, Jose Luis, primary, Abad Arranz, María, additional, Calero Acuña, Carmen, additional, Romero Valero, Fernando, additional, Ayerbe García, Ruth, additional, Hidalgo Molina, Antonio, additional, Aguilar Pérez-Grovas, Ricardo Ismael, additional, García Gil, Francisco, additional, Casas Maldonado, Francisco, additional, Caballero Ballesteros, Laura, additional, Sánchez Palop, María, additional, Pérez-Tejero, Dolores, additional, Segado, Alejandro, additional, Calvo Bonachera, Jose, additional, Hernández Sierra, Bárbara, additional, Doménech, Adolfo, additional, Arroyo Varela, Macarena, additional, González Vargas, Francisco, additional, and Cruz Rueda, Juan Jose, additional

Published
2015
Full Text
View/download PDF

38. Expresión diferencial de reactantes de fase aguda en distintos tipos celulares de pacientes con enfermedad pulmonar obstructiva crónica

Author

Calero Acuña, Carmen, López-Campos Bodineau, José Luis, and Universidad de Sevilla. Departamento de Medicina

Subjects
Enfermedades pulmonares
Abstract

La presente Tesis Doctoral se enmarca en el estudio de la enfermedad pulmonar obstructiva crónica (EPOC) como enfermedad pulmonar con repercusión sistémica y se basa en el estudio de la expresión celular diferencial de marcadores inflamatorios inespecíficos haciendo un especial hincapié en la importancia de los reactantes de fase aguda. Con objeto de centrar la exposición de la metodología y poder valorar adecuadamente los resultados, iniciaremos el presente trabajo realizando una revisión de la situación actual del tema. En concreto, revisaremos los siguientes apartados: · EPOC. Concepto actual. Donde se revisarán los aspectos principales del concepto actual de la enfermedad, así como su estadificación funcional. · Conceptos básicos sobre su diagnóstico y detección en pacientes con factores de riesgo. · Epidemiología de la EPOC. Haciendo especial énfasis en la prevalencia, mortalidad y morbilidad. · Patogenia. Datos sobre la patogenia de la enfermedad, donde se discutirán los principales tipos celulares implicados en su génesis. · Importancia de la inflamación sistémica. Evaluación de la importancia de la inflamación sistémica dentro del nuevo marco conceptual de la EPOC como enfermedad sistémica. · Reactantes de fase aguda mayores. Importancia de los reactantes de fase aguda como parte de la inflamación sistémica y base de nuestro estudio. Existe producción de RFA por el tejido pulmonar siendo ésta diferente según el territorio y el tipo celular analizado y variando entre pacientes con EPOC frente a fumadores sanos, de manera que su síntesis se encuentra relacionada con la presencia de la enfermedad. Objetivos OBJETIVOS PRINCIPALES 1. Explorar la existencia de una expresión génica de RFA en sujetos sanos y comparala con los pacientes con EPOC. 2. Comparar la expresión génica de PCR y AAS en el tejido bronquial y en parénquima de pulmón humano. 3. Determinar la expresión de PCR y AAS en células epiteliales, macrófagos y fibroblastos pulmonares humanos. 4. Comparar la expresión génica de RFA en dichos grupos celulares entre pacientes con EPOC frente a fumadores sanos.

Published
2012

41. Variability in clinical practice for chronic obstructive pulmonary disease in outpatient clinics

Author

Abad Arranz, María, primary, Calero Acuña, Carmen, additional, Romero Valero, Fernando, additional, Hidalgo Molina, Antonio, additional, Ayerbe Garcia, Ruth, additional, Aguilar Perez-Grovas, Ricardo Ismael, additional, Garcia Gil, Francisco, additional, Caballero Ballesteros, Laura, additional, Casas Maldonado, Francisco, additional, Sánchez Palop, Maria, additional, Segado Soriano, Alejandro, additional, Pérez Tejero, Dolores, additional, Calvo Bonachera, José, additional, Hernández Sierra, Bárbara, additional, Doménech del Rio, Adolfo, additional, Arroyo Valera, Macarena, additional, Gonzalez Vargas, Francisco, additional, Cruz Rueda, Juan José, additional, and López-Campos Bodineau, José Luis, additional

Published
2015
Full Text
View/download PDF

46. Evaluation of the visit frequency and the use of questionnaires and indices for COPD: a national survey from the On- Sint study.

Author

López Ramírez, Cecilia, Calero Acuña, Carmen, Represas Represas, Cristina, Aballe Santos, Luz, Casamor, Ricard, Fernández‐Villar, Alberto, and López‐Campos, José Luis

Subjects
*OBSTRUCTIVE lung diseases, *QUALITY of life, *DYSPNEA, *QUESTIONNAIRES, *MEDICAL care, *PHYSICIANS
Abstract

Introduction Despite widespread recommendations to use standardized questionnaires and multidimensional indices for the assessment of patients with chronic obstructive pulmonary disease (COPD), few data are available on the application of these tools in clinical practice. This study evaluates the attitude of physicians participating in the On-Sint cohort toward the use of health status questionnaires and multidimensional indices, as well as toward the frequency of visits and spirometry in primary care and specialized care. Methods During the constitution of the On-Sint cohort, the participating physicians were surveyed about their clinical practice. They were questioned on the frequency of spirometry and visits and on the use of various questionnaires and indices. The health status questionnaires assessed were St. George's respiratory questionnaire, chronic respiratory questionnaire, airways questionnaire 20 and COPD assessment test (CAT). Physicians were also asked about the use of the medical research council (MRC) dyspnea scale and multidimensional indices such as body mass index, airflow obstruction, dyspnea, exercise capacity (BODE). Results Of the 356 physicians who participated in the study, 258 (72.5 %) completed the investigator's questionnaire (185 primary care, 73 specialized care). Nonscheduled visits were inversely proportional to the severity of COPD. Overall, 34.1% reported using health status questionnaires, mainly CAT (20.9%). We found differences between primary and specialized care in the use of multidimensional indices (84.9% vs 47.6%; P < 0.001). Of all the participants, 33.3% reported using the MRC scale and 28.7% the BODE index. Conclusions Multidimensional indices and questionnaires are not commonly used with some differences between primary care and specialized care physicians. There is a considerable variability in the frequency of follow-up visits and spirometry. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

50. Predictors of Single Bronchodilation Treatment Response for COPD: An Observational Study with the Trace Database Cohort.

Author

Carrasco Hernández L, Caballero Eraso C, Ruiz-Duque B, Abad Arranz M, Márquez Martín E, Calero Acuña C, and Lopez-Campos JL

Abstract

Chronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single bronchodilation monotherapy in patients diagnosed with COPD. The Time-based Register and Analysis of COPD Endpoints (TRACE; clinicaltrials.gov NCT03485690) is a prospective cohort of COPD patients who have been attending annual visits since 2012. Patients who were kept on a single bronchodilator during the first year of follow-up were selected. The responders were defined according to all of the following variables: any improvement in morning post-dose forced expiratory volume in 1 s or deterioration <100 mL, no change or improvement in dyspnea score, and no occurrence of exacerbations. Significant and plausible variables were analyzed using a proportional hazard Cox regression for single bronchodilator responders. We analyzed 764 cases, of whom 128 (16.8%) were receiving monotherapy with one bronchodilator. Of these, 85 patients (66.4%) were responders. Factors affecting responder status were: female gender (hazard ratio (HR) 0.276; 95% confidence interval (CI) 0.089-0.858), dyslipidemia (HR 0.436; 95%CI 0.202-0.939), not performing regular exercise (HR 0.523; 95%CI 0.254-1.076), active smoking (HR 0.413; 95%CI 0.186-0.920), and treatment adherence (HR 2.527; 95%CI 1.271-5.027). The factors associated with a single bronchodilation response are mainly non-pharmacological interventions and comorbidities.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results