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We evaluate the maxcut of the two loops sunrise amplitude with three different masses by direct use of the loop momenta in the Minkoskean (as opposed to the usual Euclidean) continuous dimension regularisation, obtaining in that way six related but different functions expressed in the form of one dimensional finite integrals. We then consider the 4th order homogeneous equation valid for the maxcut, and show that for arbitrary dimension d the six functions do satisfy the equation separately. We further discuss the d=2,3,4 cases, verifying that only four of them are linearly independent. The equal mass limit is also shortly considered.

Piemonte is widely acknowledged as a remarkable Pliocene palaeontological spot, due to its potential for the observation and study of marine and terrestrial fossils in abundant outcrops. Our observations on about 80 palaeobotanical localities, representing both terrestrial and marine sedimentary deposits, show that some of them could easily provide more significant materials than those available today. About 30 plant-bearing Pliocene sites were selected for morphological analyses on plant fossils, mainly leaf remains. The main features of each assemblage, including the systematic placement of about 400 plant samples within 52 taxa, are indexed and described in this paper, by combining analysis of palaeontological collections and field observations. The results obtained so far encourage further studies in specific areas of palaeobotanical interest, whose results could easily provide major palaeoenvironmental insights. Finally, we suggest considering more carefully the Piemonte palaeobotanical sites in the frame of geoconservation strategies and we point out the relevance of ex-situ protection of endangered plant fossil samples (collections) in order to assure their availability for future studies.

Central Asia regions are characterized by active tectonics, high mountain chains with extreme topography with glaciers, and strong seasonal rainfall events. These key predisposing factors make large landslides a serious natural threat in the area, causing several casualties every year. The mountain crests are divided by wide lenticular or narrow, linear intermountain tectonic depressions, which are incised by many of the most important Central Asia rivers and are also subject to major seasonal river flood hazard. This multi-hazard combination is a source of potential damming scenarios, which can bring cascading effects with devastating consequences for the surrounding settlements and population. Different hazards can only be managed with a multi-hazard approach coherent within the different countries, as suggested by the requirements of the Sendai Framework for Disaster Risk Reduction. This work was carried out within the framework of the Strengthening Financial Resilience and Accelerating Risk Reduction in Central Asia (SFRARR) project as part of a multi-hazard approach with the aim of providing a damming susceptibility analysis at a regional scale for Central Asia. To achieve this, a semi-automated GIS-based mapping method, centered on a bivariate correlation of morphometric parameters defined by a morphological index, originally designed to assess the damming susceptibility at basin/regional scale, was modified to be adopted nationwide and applied to spatially assess the obstruction of the river network in Central Asia for mapped and newly formed landslides. The proposed methodology represents an improvement to the previously designed methodology, requiring a smaller amount of data, bringing new preliminary information on damming hazard management and risk reduction, and identifying the most critical area within the Central Asia regions.

Abstract Background BRCA1:c.5017_5019del (p.His1673del) is a founder variant relatively frequent in Northern Italy. Despite previous suggestion of pathogenicity, variant classification in public databases is still conflicting, needing additional evidence. Methods Maximum likelihood penetrance of breast/ovarian and other cancer types was estimated using full pedigree data from 53 informative Italian families. The effect of the variant on BRCA1‐ABRAXAS1 interaction was assessed using a GFP‐fragment reassembly‐based PPI assay. Results were combined with additional data from multiple sources to classify the variant according to ACMG/AMP classification rules specified for BRCA1/2. Results Variant‐carriers displayed increased risk for ovarian cancer (HR = 33.0, 95% CI = 7.0–155.0; cumulative risk at age 70 = 27.6%, 95% CI = 12.6–40.0%) but not for breast cancer (HR = 0.7, 95% CI = 0.2–2.2). An increased risk of uterine cancer (HR = 8.0, 95% CI = 1.03–61.6) emerged, warranting further evaluation. Likelihood‐ratio in favor of pathogenicity was 98898642.82 under assumption of standard BRCA1 breast and ovarian penetrance, and 104240832.84 after excluding breast cancer diagnoses (based on penetrance results). Functional analysis demonstrated that the variant abrogates the BRCA1‐ABRAXAS1 binding, supporting the PS3 code assignment within the ACMG/AMP rule‐based model. Collectively, these findings allowed to classify the variant as pathogenic. Conclusion Pathogenicity of BRCA1:c.5017_5019del(p.His1673del) has been confirmed; however, breast cancer risk in Italian families is not increased, unlike in families from other countries and in carriers of most BRCA1 pathogenic variants. The knowledge of atypical risk profiles for this and other variants will pave the way for personalized management based on specific genotype.

Landslides are widespread phenomena that occur in any terrestrial area with slopes, causing massive property damage and, in the worst-case scenario, loss of human life. This propensity to suffer losses is particularly high for developing countries due to their urban development, population growth and drastic land use changes. Social and economic consequences of landslides can be reduced through detailed planning and management strategies, which can be aided by risk analysis. In this study, we performed a detailed quantitative risk analysis for landslides in the whole of Central Asia (4 000 000 km2). Landslide-induced risk was computed, using a 200 m spatial resolution, in terms of exposed population and expected economic losses to buildings and linear infrastructures (roads and railways). The purpose of our study is to produce the first regional-scale landslide risk assessment for Central Asia in order to inform regional-scale risk mitigation strategies, and it represents an advanced step in the landslide risk analysis for extremely broad areas.

The analytical performance of the new Aspergillus Galactomannan Ag VirCLIA® mono-test (Vircell S.L.) was compared to the Platelia™ Aspergillus Ag ELISA assay (Bio-Rad). Prospective serum and bronchoalveolar lavage (BAL) samples from patients at risk of invasive aspergillosis (IA) were tested using both the Aspergillus Galactomannan Ag VirCLIA® mono-test and the Platelia™ Aspergillus Ag ELISA assay. Concordance, sensitivity, specificity, and positive and negative predictive values were calculated using the manufacturer-recommended cutoff levels. Receiver operating characteristic (ROC) analysis and the Youden index were performed to determine the optimal cutoff. A total of 187 serum samples and 73 BAL samples were analyzed with both assays. The concordance between the Aspergillus Galactomannan Ag VirCLIA® mono-test and the Platelia™ Aspergillus Ag ELISA assay was 87.8%, with a Cohen’s kappa of 0.75. The sensitivity and specificity of the Aspergillus Galactomannan Ag VirCLIA® mono-test were 78.6% and 96.2%, respectively, with positive and negative predictive values of 94.8% and 83.3%. The ROC curve for the Aspergillus Galactomannan Ag VirCLIA® mono-test demonstrated an area under the curve (AUC) of 0.87, and the Youden index at the manufacturer’s established cutoff was 0.73. This new Aspergillus Galactomannan Ag VirCLIA® mono-test exhibited adequate analytical and clinical performance, showing good correlation with the Platelia™ Aspergillus Ag ELISA assay. The single-sample, semi-automated test is user-friendly, allowing small laboratories to perform the test on demand without the need for batch evaluations, providing a useful solution for timely diagnostic support for clinicians.

Central Asia is an area characterized by complex tectonics and active deformation; the related seismic activity controls the earthquake hazard level that, due to the occurrence of secondary and tertiary effects, also has direct implications for the hazard related to mass movements such as landslides, which are responsible for an extensive number of casualties every year. Climatically, this region is characterized by strong rainfall gradient contrasts due to the diversity of climate and vegetation zones. The region is drained by large, partly snow- and glacier-fed rivers that cross or terminate in arid forelands; therefore, it is also affected by a significant river flood hazard, mainly in spring and summer seasons. The challenge posed by the combination of different hazards can only be tackled by considering a multi-hazard approach harmonized among the different countries, in agreement with the requirements of the Sendai Framework for Disaster Risk Reduction. This work was carried out within the framework of the Strengthening Financial Resilience and Accelerating Risk Reduction in Central Asia (SFRARR) project as part of a multi-hazard approach and is focused on the first landslide susceptibility analysis at a regional scale for Central Asia. To this aim the most detailed landslide inventories, covering both national and transboundary territories, were implemented in a random forest model, together with several independent variables. The proposed approach represents an innovation in terms of resolution (from 30 to 70 m) and extension of the analyzed area with respect to previous regional landslide susceptibility and hazard zonation models applied in Central Asia. The final aim was to provide a useful tool for land use planning and risk reduction strategies for landslide scientists, practitioners, and administrators.

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.

The clinical screening of cancer predisposition genes has led to the identification of a large number of variants of uncertain significance (VUS). Multifactorial likelihood models that predict the odds ratio for VUS in favor or against cancer causality, have been developed, but their use is limited by the amount of necessary data, which are difficult to obtain for rare variants. The guidelines for variant interpretation of the American College of Medical Genetics and Genomics along with the Association for Molecular Pathology (ACMG/AMP) state that “well-established” functional studies provide strong support of a pathogenic or benign impact (criteria PS3 and BS3, respectively) and can be used as evidence type to reach a final classification. Moreover, the Clinical Genome Resource Sequence Variant Interpretation Working Group developed rule specifications to refine the PS3/BS3 criteria. Recently, Lira PC et al. developed the “Hi Set” approach that generated PS3/BS3 codes for over two-thousands BRCA1 VUS. While highly successful, this approach did not discriminate a group of variants with conflicting evidences. Here, we aimed to implement the outcomes of the “Hi-set” approach applying Green Fluorescent Protein (GFP)-reassembly assays, assessing the effect of variants in the RING and BRCT domains of BRCA1 on the binding of these domains with the UbcH5a or ABRAXAS proteins, respectively. The analyses of 26 clinically classified variants, including 13 tested in our previous study, showed 100% sensitivity and specificity in identifying pathogenic and benign variants for both the RING/UbcH5a and the BRCTs/ABRAXAS interactions. We derived the strength of evidences generated by the GFP-reassembly assays corresponding to moderate for both PS3 and BS3 criteria assessment. The GFP-reassembly assays were applied to the functional characterization of 8 discordant variants from the study by Lyra et al. The outcomes of these analyses, combined with those reported in the “Hi Set” study, allowed the assignment of ACMG/AMP criteria in favor or against pathogenicity for all 8 examined variants. The above findings were validated with a semi-quantitative Mammalian Two-Hybrid approach, and totally concordant results were observed. Our data contributes in shedding light on the functional significance of BRCA1 VUS and on their clinical interpretation within the ACMG/AMP framework.

The analytical performance of the new Aspergillus Galactomannan Ag VirCLIA® mono-test (Vircell S.L.) was compared to the Platelia™ Aspergillus Ag ELISA assay (Bio-Rad). Prospective serum and bronchoalveolar lavage (BAL) samples from patients at risk of invasive aspergillosis (IA) were tested using both the Aspergillus Galactomannan Ag VirCLIA® mono-test and the Platelia™ Aspergillus Ag ELISA assay. Concordance, sensitivity, specificity, and positive and negative predictive values were calculated using the manufacturer-recommended cutoff levels. Receiver operating characteristic (ROC) analysis and the Youden index were performed to determine the optimal cutoff. A total of 187 serum samples and 73 BAL samples were analyzed with both assays. The concordance between the Aspergillus Galactomannan Ag VirCLIA® mono-test and the Platelia™ Aspergillus Ag ELISA assay was 87.8%, with a Cohen's kappa of 0.75. The sensitivity and specificity of the Aspergillus Galactomannan Ag VirCLIA® mono-test were 78.6% and 96.2%, respectively, with positive and negative predictive values of 94.8% and 83.3%. The ROC curve for the Aspergillus Galactomannan Ag VirCLIA® mono-test demonstrated an area under the curve (AUC) of 0.87, and the Youden index at the manufacturer's established cutoff was 0.73. This new Aspergillus Galactomannan Ag VirCLIA® mono-test exhibited adequate analytical and clinical performance, showing good correlation with the Platelia™ Aspergillus Ag ELISA assay. The single-sample, semi-automated test is user-friendly, allowing small laboratories to perform the test on demand without the need for batch evaluations, providing a useful solution for timely diagnostic support for clinicians. [ABSTRACT FROM AUTHOR]

Although the spliceogenic nature of the BRCA2 c.68-7T > A variant has been demonstrated, its association with cancer risk remains controversial. In this study, we accurately quantified by real-time PCR and digital PCR (dPCR), the BRCA2 isoforms retaining or missing exon 3. In addition, the combined odds ratio for causality of the variant was estimated using genetic and clinical data, and its associated cancer risk was estimated by case-control analysis in 83,636 individuals. Co-occurrence in trans with pathogenic BRCA2 variants was assessed in 5,382 families. Exon 3 exclusion rate was 4.5-fold higher in variant carriers (13%) than controls (3%), indicating an exclusion rate for the c.68-7T > A allele of approximately 20%. The posterior probability of pathogenicity was 7.44 × 10-115 . There was neither evidence for increased risk of breast cancer (OR 1.03; 95% CI 0.86-1.24) nor for a deleterious effect of the variant when co-occurring with pathogenic variants. Our data provide for the first time robust evidence of the nonpathogenicity of the BRCA2 c.68-7T > A. Genetic and quantitative transcript analyses together inform the threshold for the ratio between functional and altered BRCA2 isoforms compatible with normal cell function. These findings might be exploited to assess the relevance for cancer risk of other BRCA2 spliceogenic variants.

Landslides are a worldwide natural hazard that cause more damage and casualties than other hazards. Therefore, social and economic losses can be reduced through a landslide quantitative risk assessment (QRA). In the last two decades, many attempts of quantitative analysis on various scales have been performed; nevertheless, the major difficulty of QRA lies in how precise and reliable the assessment should have to be useful. For this reason, in this paper, we analyzed different freely available datasets and some products of previous research to assess the soundness of the outcomes performed by a recent QRA of slow-moving landslides in the Arno River basin (Central Italy). The validation process was carried out by comparing the abovementioned datasets and two components of the selected QRA (hazard and risk). The obtained results showed a robust correlation between most of the testing dataset and risk components, highlighting the accuracy of the selected QRA.

Background: BRCA1:c.5017_5019del (p.His1673del) is a founder variant relatively frequent in Northern Italy. Despite previous suggestion of pathogenicity, variant classification in public databases is still conflicting, needing additional evidence. Methods: Maximum likelihood penetrance of breast/ovarian and other cancer types was estimated using full pedigree data from 53 informative Italian families. The effect of the variant on BRCA1‐ABRAXAS1 interaction was assessed using a GFP‐fragment reassembly‐based PPI assay. Results were combined with additional data from multiple sources to classify the variant according to ACMG/AMP classification rules specified for BRCA1/2. Results: Variant‐carriers displayed increased risk for ovarian cancer (HR = 33.0, 95% CI = 7.0–155.0; cumulative risk at age 70 = 27.6%, 95% CI = 12.6–40.0%) but not for breast cancer (HR = 0.7, 95% CI = 0.2–2.2). An increased risk of uterine cancer (HR = 8.0, 95% CI = 1.03–61.6) emerged, warranting further evaluation. Likelihood‐ratio in favor of pathogenicity was 98898642.82 under assumption of standard BRCA1 breast and ovarian penetrance, and 104240832.84 after excluding breast cancer diagnoses (based on penetrance results). Functional analysis demonstrated that the variant abrogates the BRCA1‐ABRAXAS1 binding, supporting the PS3 code assignment within the ACMG/AMP rule‐based model. Collectively, these findings allowed to classify the variant as pathogenic. Conclusion: Pathogenicity of BRCA1:c.5017_5019del(p.His1673del) has been confirmed; however, breast cancer risk in Italian families is not increased, unlike in families from other countries and in carriers of most BRCA1 pathogenic variants. The knowledge of atypical risk profiles for this and other variants will pave the way for personalized management based on specific genotype. [ABSTRACT FROM AUTHOR]

The hymenopteran family Platygastridae is a large group of parasitic wasps. A survey was carried out on the subfamily Sceliotrachelinae (Hym.: Platygastridae) in East Azerbaijan and Fars provinces of Iran. The genus Fidobia Ashmead and three species, Allotropa conventus Maneval, Fidiobia hofferi Kozlov and Isolia mongolica (Kozlov) are newly recorded from Iran. Illustrations of the morphological characteristics and their geographical distribution are presented.

Central Asia regions are characterized by active tectonics, high mountain chains with extreme topography with glaciers, and strong seasonal rainfall events. These key predisposing factors make large landslides a serious natural threat in the area, causing several casualties every year. The mountain crests are divided by wide lenticular or narrow, linear intermountain tectonic depressions, which are incised by many of the most important Central Asia rivers and are also subject to major seasonal river flood hazard. This multi-hazard combination is a source of potential damming scenarios, which can bring cascading effects with devastating consequences for the surrounding settlements and population. Different hazards can only be managed with a multi-hazard approach coherent within the different countries, as suggested by the requirements of the Sendai Framework for Disaster Risk Reduction. This work was carried out within the framework of the Strengthening Financial Resilience and Accelerating Risk Reduction in Central Asia (SFRARR) project as part of a multi-hazard approach with the aim of providing a damming susceptibility analysis at a regional scale for Central Asia. To achieve this, a semi-automated GIS-based mapping method, centered on a bivariate correlation of morphometric parameters defined by a morphological index, originally designed to assess the damming susceptibility at basin/regional scale, was modified to be adopted nationwide and applied to spatially assess the obstruction of the river network in Central Asia for mapped and newly formed landslides. The proposed methodology represents an improvement to the previously designed methodology, requiring a smaller amount of data, bringing new preliminary information on damming hazard management and risk reduction, and identifying the most critical area within the Central Asia regions. [ABSTRACT FROM AUTHOR]

Accurate identification of parasitoids is crucial for biological control of the invasive brown marmorated stink bug, Halyomrpha halys (Stål). A recent work by Talamas et al. (2017) revised the Palearctic fauna of Trissolcus Ashmead, egg-parasitoids of stink bugs, and treated numerous species as junior synonyms of T. semistriatus (Nees von Esenbeck). In the present paper, we provide a detailed taxonomic history and treatment of T. semistriatus and the species treated as its synonyms by Talamas et al. (2017) based on examination of primary types, molecular analyses and mating experiments. Trissolcus semistriatus, T. belenus (Walker), T. colemani (Crawford), and T. manteroi (Kieffer) are here recognized as valid and a key to species is provided. The identification tools provided here will facilitate the use of Trissolcus wasps as biological control agents and as the subject of ecological studies.

Anchonocranus oleae Marshall (Coleoptera: Curculionidae) is a seed-feeding weevil native to southern Africa; its larvae are known to develop in the fruits of the African Wild Olive and, more rarely, cultivated olives. The species has been mainly found in the Western Cape province of South Africa, but it has remained in relative obscurity because it does not seem to represent a current threat to commercial olive production. As part of an ongoing effort to produce baseline genetic data for olive-associated entomofauna in South Africa, we generated reference DNA barcodes for A. oleae collected from wild and cultivated olives and sequenced its mitogenome for assessment of the phylogenetic position of the species in the family Curculionidae. The mitochondrial phylogeny estimate indicated that A. oleae shares a common ancestor with Elaidobius (tribe Derelomini), but a definite and close relationship to this tribe and the precise tribal placement of A. oleae in the subfamily Curculioninae could not be inferred due to the lack of representative mitogenomes of other relevant curculionine tribes and genera. This study will assist future work on the DNA-based species identification, genetic diversity, and phylogenetic position of the genus Anchonocranus and related taxa.

Wild and cultivated olives harbor and share a diversity of insects, some of which are considered agricultural pests, such as the olive fruit fly. The assemblage of olive-associated parasitoids and seed wasps is rich and specialized in sub-Saharan Africa, with native species possibly coevolving with their hosts. Although historical entomological surveys reported on the diversity of olive wasp species in the Western Cape Province of South Africa, no comprehensive study has been performed in the region in the molecular era. In this study, a dual approach combining morphological and DNA-based methods was used for the identification of adult specimens reared from olive fruits. Four species of Braconidae and six species of Chalcidoidea were identified, and DNA barcoding methodologies were used to investigate conspecificity among individuals, based on randomly selected representative specimens. Morphological identifications were congruent with DNA data, as NJ and ML trees correctly placed the sequences for each species either at the genus or species level, depending on the available taxa coverage, and genetic distances strongly supported conspecificity. No clear evidence of cryptic diversity was found. Overall seed infestation and parasitism rates were higher in wild olives compared to cultivated olives, and highest for Eupelmus spermophilus and Utetes africanus. These results can be used for early DNA-based detection of wasp larvae in olives and to further investigate the biology and ecology of these species. Key words: Braconidae, Chalcidoidea, DNA barcoding, olives, species identification. Les olives sauvages et cultivees abritent et partagent une grande diversite d'insectes, dont certains sont consideres comme des ravageurs, comme la mouche de l'olive. Il existe une riche diversite de parasitoides et de guepes seminivores specialises associes aux oliviers en Afrique subsaharienne, dont plusieurs especes indigenes qui auraient co-evolue avec leurs hotes. Bien que des enquetes entomologiques historiques aient rapporte la diversite des guepes de l'olive dans la province du Cap-Occidental en Afrique du Sud, aucune etude approfondie n'a ete realisee dans cette region depuis l'avenement de methodes moleculaires. Dans ce travail, une approche double combinant des methodes morphologiques et basees sur l'ADN ont ete employees pour identifier des specimens adultes eleves sur des olives. Quatre especes de Braconidae et six especes de Chalcidoidea ont ete identifiees sur la base de la morphologie et des methodes de codage a barres de l'ADN ont ete employees pour etudier la conspecificite chez des individus choisis au hasard parmi des specimens representatifs. Les identifications morphologiques etaient en accord avec les donnees moleculaires car les arbres NJ et ML ont correctement place les sequences de chacune des especes, soit en fonction du genre ou de l'espece selon la couverture des taxons, et les distances genetiques ont fortement supporte la conspecificite. Aucune evidence claire de diversite cryptique n'a ete trouvee. Globalement, les niveaux d'infestation des graines et les taux de parasitisme etaient plus eleves chez les olives sauvages que chez les olives cultivees, atteignant un sommet chez l'Eupelmus spermophilus et l'Utetes africanus. Ces resultats pourront servir a la detection moleculaire precoce des larves de guepes dans les olives et pour etudier la biologie et l'ecologie de ces especes. [Traduit par la Redaction] Mots-cles : Braconidae, Chalcidoidea, codage a barres de l'ADN, olives, identification des especes., Introduction The wild olive tree (Olea europaea L. subsp. cuspidata) is closely related to the cultivated olive tree (Olea europaea L. subsp. europaea var. europaea) (Green 2002). The subspecies is [...]

Piemonte is widely acknowledged as a remarkable Pliocene palaeontological spot, due to its potential for the observation and study of marine and terrestrial fossils in abundant outcrops. Our observations on about 80 palaeobotanical localities, representing both terrestrial and marine sedimentary deposits, show that some of them could easily provide more significant materials than those available today. About 30 plant-bearing Pliocene sites were selected for morphological analyses on plant fossils, mainly leaf remains. The main features of each assemblage, including the systematic placement of about 400 plant samples within 52 taxa, are indexed and described in this paper, by combining analysis of palaeontological collections and field observations. The results obtained so far encourage further studies in specific areas of palaeobotanical interest, whose results could easily provide major palaeoenvironmental insights. Finally, we suggest considering more carefully the Piemonte palaeobotanical sites in the frame of geoconservation strategies and we point out the relevance of ex-situ protection of endangered plant fossil samples (collections) in order to assure their availability for future studies. [ABSTRACT FROM AUTHOR]

Landslides are widespread phenomena that occur in any terrestrial area with slopes, causing massive property damage and, in the worst-case scenario, loss of human life. This propensity to suffer losses is particularly high for developing countries due to their urban development, population growth and drastic land use changes. Social and economic consequences of landslides can be reduced through detailed planning and management strategies, which can be aided by risk analysis. In this study, we performed a detailed quantitative risk analysis for landslides in the whole of Central Asia (4 000 000 km2). Landslide-induced risk was computed, using a 200 m spatial resolution, in terms of exposed population and expected economic losses to buildings and linear infrastructures (roads and railways). The purpose of our study is to produce the first regional-scale landslide risk assessment for Central Asia in order to inform regional-scale risk mitigation strategies, and it represents an advanced step in the landslide risk analysis for extremely broad areas. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to propose a new set of environmental indicators for the fast estimation of landslide risk over very wide areas. Using Italy (301,340 km2) as a test case, landslide susceptibility maps and soil sealing/land consumption maps were combined to derive a spatially distributed indicator (LRI—landslide risk index), then an aggregation was performed using Italian municipalities as basic spatial units. Two indicators were defined, namely ALR (averaged landslide risk) and TLR (total landslide risk). All data were processed using GIS programs. Conceptually, landslide susceptibility maps account for landslide hazard while soil sealing maps account for the spatial distribution of anthropic elements exposed to risk (including buildings, infrastructure, and services). The indexes quantify how much the two issues overlap, producing a relevant risk and can be used to evaluate how each municipality has been prudent in planning sustainable urban growth to cope with landslide risk. The proposed indexes are indicators that are simple to understand, can be adapted to various contexts and at various scales, and could be periodically updated, with very low effort, making use of the products of ongoing governmental monitoring programs of Italian environment. Of course, the indicators represent an oversimplification of the complexity of landslide risk, but this is the first time that a landslide risk indicator has been defined in Italy at the national scale, starting from landslide susceptibility maps (although Italy is one of the European countries most affected by hydro-geological hazards) and, more in general, the first time that land consumption maps are integrated into a landslide risk assessment.