3,330 results on '"Caldwell, M."'
Search Results
2. SPICE Connection Mosaics to link the Sun's surface and the heliosphere
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Varesano, T., Hassler, D. M., Prado, N. Zambrana, Plowman, J., Del Zanna, G., Parenti, S., Mason, H. E., Giunta, A., Auchere, F., Carlsson, M., Fludra, A., Peter, H., Muller, D., Williams, D., Cuadrado, R. Aznar, Barczynski, K., Buchlin, E., Caldwell, M., Fredvik, T., Grundy, T., Guest, S., Harra, L., Janvier, M., Kucera, T., Leeks, S., Schmutz, W., Schuehle, U., Sidher, S., Teriaca, L., Thompson, W., and Yardley, S. L.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present an analysis of the first connection mosaic made by the SPICE instrument on board of the ESA / NASA Solar Orbiter mission on March 2nd, 2022. The data will be used to map coronal composition that will be compared with in-situ measurements taken by SWA/HIS to establish the coronal origin of the solar wind plasma observed at Solar Orbiter. The SPICE spectral lines were chosen to have varying sensitivity to the First Ionization Potential (FIP) effect, and therefore the radiances of the spectral lines will vary significantly depending on whether the elemental composition is coronal or photospheric. We investigate the link between the behavior of sulfur with the hypothesis that Alfv\'en waves drive FIP fractionation above the chromosphere. We perform temperature diagnostics using line ratios and Emission Measure (EM) loci, and compute relative FIP biases using three different approaches (two line ratio (2LR), ratios of linear combinations of spectral lines (LCR), and differential emission measure (DEM) inversion) to perform composition diagnostics in the corona. We then compare the SPICE composition analysis and EUI data of the potential solar wind source regions to the SWA / HIS data products. Radiance maps are extracted from SPICE spectral data cubes, with values matching previous observations. We find isothermal plasma of around LogT = 5.8 for the active region loops targeted, and that higher FIP-bias values are present at the footpoints of the coronal loops associated with two active regions. Comparing the results with the SWA/HIS data products encourages us to think that Solar Orbiter was connected to a source of slow solar wind during this observation campaign. We demonstrate FIP fractionation in observations of the upper chromosphere and transition region, emphasized by the behavior of the intermediate-FIP element sulfur., Comment: 20 pages, 19 figures, submitted to A&A on August 3rd, accepted on February 12th, 2024
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- 2023
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3. A multiple spacecraft detection of the 2 April 2022 M-class flare and filament eruption during the first close Solar Orbiter perihelion
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Janvier, M., Mzerguat, S., Young, P. R., Buchlin, É., Manou, A., Pelouze, G., Long, D. M., Green, L., Warmuth, A., Schuller, F., Démoulin, P., Calchetti, D., Kahil, F., Rubio, L. Bellot, Parenti, S., Baccar, S., Barczynski, K., Harra, L. K., Hayes, L. A., Thompson, W. T., Müller, D., Baker, D., Yardley, S., Berghmans, D., Verbeeck, C., Smith, P. J., Peter, H., Cuadrado, R. Aznar, Musset, S., Brooks, D. H., Rodriguez, L., Auchère, F., Carlsson, M., Fludra, A., Hassler, D., Williams, D., Caldwell, M., Fredvik, T., Giunta, A., Grundy, T., Guest, S., Kraaikamp, E., Leeks, S., Plowman, J., Schmutz, W., Schühle, U., Sidher, S. D., Teriaca, L., Solanki, S. K., Iniesta, J. C. del Toro, Woch, J., Gandorfer, A., Hirzberger, J., Suarez, D. Orozco, Appourchaux, T., Valori, G., Sinjan, J., Albert, K., and Volkmer, R.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The Solar Orbiter mission completed its first remote-sensing observation windows in the spring of 2022. On 2/4/2022, an M-class flare followed by a filament eruption was seen both by the instruments on board the mission and from several observatories in Earth's orbit. The complexity of the observed features is compared with the predictions given by the standard flare model in 3D. We use the observations from a multi-view dataset, which includes EUV imaging to spectroscopy and magnetic field measurements. These data come from IRIS, SDO, Hinode, as well as several instruments on Solar Orbiter. Information given by SDO/HMI and Solar Orbiter PHI/HRT shows that a parasitic polarity emerging underneath the filament is responsible for bringing the flux rope to an unstable state. As the flux rope erupts, Hinode/EIS captures blue-shifted emission in the transition region and coronal lines in the northern leg of the flux rope prior to the flare peak. Solar Orbiter SPICE captures the whole region, complementing the Doppler diagnostics of the filament eruption. Analyses of the formation and evolution of a complex set of flare ribbons and loops show that the parasitic emerging bipole plays an important role in the evolution of the flaring region. While the analysed data are overall consistent with the standard flare model, the present particular magnetic configuration shows that surrounding magnetic activity such as nearby emergence needs to be taken into account to fully understand the processes at work. This filament eruption is the first to be covered from different angles by spectroscopic instruments, and provides an unprecedented diagnostic of the multi-thermal structures present before and during the flare. This dataset of an eruptive event showcases the capabilities of coordinated observations with the Solar Orbiter mission., Comment: Accepted for publication in the Astronomy & Astrophysics special edition "Solar Orbiter First Results (Nominal Mission Phase)" (23/05/2023)
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- 2023
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4. First observations from the SPICE EUV spectrometer on Solar Orbiter
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Fludra, A., Caldwell, M., Giunta, A., Grundy, T., Guest, S., Leeks, S., Sidher, S., Auchère, F., Carlsson, M., Hassler, D., Peter, H., Cuadrado, R. Aznar, Buchlin, É., Caminade, S., DeForest, C., Fredvik, T., Haberreiter, M., Harra, L., Janvier, M., Kucera, T., Müller, D., Parenti, S., Schmutz, W., Schühle, U., Solanki, S. K., Teriaca, L., Thompson, W. T., Tustain, S., Williams, D., Young, P. R., and Chitta, L. P.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present first science observations taken during the commissioning activities of the Spectral Imaging of the Coronal Environment (SPICE) instrument on the ESA/NASA Solar Orbiter mission. SPICE is a high-resolution imaging spectrometer operating at extreme ultraviolet (EUV) wavelengths. In this paper we illustrate the possible types of observations to give prospective users a better understanding of the science capabilities of SPICE. The paper discusses the first observations of the Sun on different targets and presents an example of the full spectra from the quiet Sun, identifying over 40 spectral lines from neutral hydrogen and ions of carbon, oxygen, nitrogen, neon, sulphur, magnesium, and iron. These lines cover the temperature range between 20,000 K and 1 million K (10MK in flares), providing slices of the Sun's atmosphere in narrow temperature intervals. We provide a list of count rates for the 23 brightest spectral lines. We show examples of raster images of the quiet Sun in several strong transition region lines, where we have found unusually bright, compact structures in the quiet Sun network, with extreme intensities up to 25 times greater than the average intensity across the image. The lifetimes of these structures can exceed 2.5 hours. We identify them as a transition region signature of coronal bright points and compare their areas and intensity enhancements. We also show the first above-limb measurements with SPICE above the polar limb in C III, O VI, and Ne VIII lines, and far off limb measurements in the equatorial plane in Mg IX, Ne VIII, and O VI lines. We discuss the potential to use abundance diagnostics methods to study the variability of the elemental composition that can be compared with in situ measurements to help confirm the magnetic connection between the spacecraft location and the Sun's surface, and locate the sources of the solar wind., Comment: 14 pages, 10 figures. Accepted for publication in A&A
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- 2021
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5. A conserved tooth resorption mechanism in modern and fossil snakes
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LeBlanc, A. R. H., Palci, A., Anthwal, N., Tucker, A. S., Araújo, R., Pereira, M. F. C., and Caldwell, M. W.
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- 2023
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6. Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution
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Lauren J. Donovan, Caldwell M. Bridges, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Sabrina F. Bond, Claire E. Jordan, Aysha M. Gardner, Ramesh V. Nair, and Vivianne L. Tawfik
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CP: Neuroscience ,Biology (General) ,QH301-705.5 - Abstract
Summary: Microglia are implicated as primarily detrimental in pain models; however, they exist across a continuum of states that contribute to homeostasis or pathology depending on timing and context. To clarify the specific contribution of microglia to pain progression, we take advantage of a temporally controlled transgenic approach to transiently deplete microglia. Unexpectedly, we observe complete resolution of pain coinciding with microglial repopulation rather than depletion. We find that repopulated mouse spinal cord microglia are morphologically distinct from control microglia and exhibit a unique transcriptome. Repopulated microglia from males and females express overlapping networks of genes related to phagocytosis and response to stress. We intersect the identified mouse genes with a single-nuclei microglial dataset from human spinal cord to identify human-relevant genes that may ultimately promote pain resolution after injury. This work presents a comprehensive approach to gene discovery in pain and provides datasets for the development of future microglial-targeted therapeutics.
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- 2024
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7. Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution
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Donovan, Lauren J., Bridges, Caldwell M., Nippert, Amy R., Wang, Meng, Wu, Shaogen, Forman, Thomas E., Haight, Elena S., Huck, Nolan A., Bond, Sabrina F., Jordan, Claire E., Gardner, Aysha M., Nair, Ramesh V., and Tawfik, Vivianne L.
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- 2024
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8. The Solar Orbiter SPICE instrument -- An extreme UV imaging spectrometer
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Consortium, The SPICE, Anderson, M., Appourchaux, T., Auchère, F., Cuadrado, R. Aznar, Barbay, J., Baudin, F., Beardsley, S., Bocchialini, K., Borgo, B., Bruzzi, D., Buchlin, E., Burton, G., Blüchel, V., Caldwell, M., Caminade, S., Carlsson, M., Curdt, W., Davenne, J., Davila, J., DeForest, C. E., Del Zanna, G., Drummond, D., Dubau, J., Dumesnil, C., Dunn, G., Eccleston, P., Fludra, A., Fredvik, T., Gabriel, A., Giunta, A., Gottwald, A., Griffin, D., Grundy, T., Guest, S., Gyo, M., Haberreiter, M., Hansteen, V., Harrison, R., Hassler, D. M., Haugan, S. V. H., Howe, C., Janvier, M., Klein, R., Koller, S., Kucera, T. A., Kouliche, D., Marsch, E., Marshall, A., Marshall, G., Matthews, S. A., McQuirk, C., Meining, S., Mercier, C., Morris, N., Morse, T., Munro, G., Parenti, S., Pastor-Santos, C., Peter, H., Pfiffner, D., Phelan, P., Philippon, A., Richards, A., Rogers, K., Sawyer, C., Schlatter, P., Schmutz, W., Schühle, U., Shaughnessy, B., Sidher, S., Solanki, S. K., Speight, R., Spescha, M., Szwec, N., Tamiatto, C., Teriaca, L., Thompson, W., Tosh, I., Tustain, S., Vial, J. -C., Walls, B., Waltham, N., Wimmer-Schweingruber, R., Woodward, S., Young, P., De Groof, A., Pacros, A., Williams, D., and Müller, D.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The Spectral Imaging of the Coronal Environment (SPICE) instrument is a high-resolution imaging spectrometer operating at extreme ultraviolet (EUV) wavelengths. In this paper, we present the concept, design, and pre-launch performance of this facility instrument on the ESA/NASA Solar Orbiter mission. The goal of this paper is to give prospective users a better understanding of the possible types of observations, the data acquisition, and the sources that contribute to the instrument's signal. The paper discusses the science objectives, with a focus on the SPICE-specific aspects, before presenting the instrument's design, including optical, mechanical, thermal, and electronics aspects. This is followed by a characterisation and calibration of the instrument's performance. The paper concludes with descriptions of the operations concept and data processing. The performance measurements of the various instrument parameters meet the requirements derived from the mission's science objectives. The SPICE instrument is ready to perform measurements that will provide vital contributions to the scientific success of the Solar Orbiter mission., Comment: A&A, accepted 19 August 2019; 26 pages, 25 figures
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- 2019
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9. Efficacy of the AS04-adjuvanted HPV-16/18 vaccine: Pooled analysis of the Costa Rica Vaccine and PATRICIA randomized controlled trials
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Tota, Joseph E, Struyf, Frank, Sampson, Joshua N, Gonzalez, Paula, Ryser, Martin, Herrero, Rolando, Schussler, John, Karkada, Naveen, Rodriguez, Ana Cecilia, Folschweiller, Nicolas, Porras, Carolina, Schiffman, Mark, Schiller, John T, Quint, Wim, Kreimer, Aimée R, Wheeler, Cosette M, Hildesheim, Allan, Cortés, Bernal, González, Paula, Jiménez, Silvia E, Rodríguez, Ana Cecilia, Lowy, Douglas R, Wacholder, Sholom, Pinto, Ligia A, Kemp, Troy J, van Doorn, Leen-Jan, Struijk, Linda, Palefsky, Joel M, Darragh, Teresa M, Stoler, Mark H, Garland, SM, Skinner, SR, De Sutter, P, Poppe, WAJ, De Carvalho, NS, Teixeira, JC, Ferguson, L, Ferguson, M, Papp, K, Ramjattan, B, Orr, PH, Paavonen, J, Höpker, WD, Tobgui, S Jensen-El, Liverani, CA, Limson, GM, Marti, M Campins, Castro, M, Centeno, C, Chow, SN, Angsuwathana, S, Lewis, D, Ackerman, R, Caldwell, M, Chambers, C, Chatterjee, A, Harper, D, Sperling, R, Stapleton, J, Waldbaum, A, Lee, P, and Awedikian, Rafi
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Sexually Transmitted Infections ,Immunization ,Cancer ,Biotechnology ,Infectious Diseases ,HPV and/or Cervical Cancer Vaccines ,Vaccine Related ,Clinical Research ,Clinical Trials and Supportive Activities ,Cervical Cancer ,Prevention ,HIV/AIDS ,Adjuvants ,Immunologic ,Adolescent ,Adult ,Costa Rica ,Female ,Human papillomavirus 16 ,Human papillomavirus 18 ,Humans ,Papillomavirus Infections ,Papillomavirus Vaccines ,Randomized Controlled Trials as Topic ,Retrospective Studies ,Treatment Outcome ,Uterine Cervical Neoplasms ,Young Adult ,Uterine Cervical Dysplasia ,Costa Rica Vaccine Trial and PATRICIA Study ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundThe AS04-adjuvanted HPV16/18 (AS04-HPV16/18) vaccine provides excellent protection against targeted human papillomavirus (HPV) types and a variable degree of cross-protection against others, including types 6/11/31/33/45. High efficacy against any cervical intraepithelial neoplasia grade 3 or greater (CIN3+; >90%) suggests that lower levels of protection may exist for a wide range of oncogenic HPV types, which is difficult to quantify in individual trials. Pooling individual-level data from two randomized controlled trials, we aimed to evaluate AS04-HPV16/18 vaccine efficacy against incident HPV infections and cervical abnormalities .MethodsData were available from the Costa Rica Vaccine Trial (NCT00128661) and Papilloma Trial Against Cancer in Young Adults trial (NCT00122681), two large-scale, double-blind randomized controlled trials of the AS04-HPV16/18 vaccine. Primary analyses focused on disease-free women with no detectable cervicovaginal HPV at baseline.ResultsA total of 12 550 women were included in our primary analyses (HPV arm = 6271, control arm = 6279). Incidence of 6-month persistent oncogenic and nononcogenic infections, excluding known and accepted protected types 6/11/16/18/31/33/45 (focusing on 34/35/39/40/42/43/44/51/52/53/54/56/58/59/66/68/73/70/74), was statistically significantly lower in the HPV arm than in the control arm (efficacy = 9.9%, 95% confidence interval [CI] = 1.7% to 17.4%). Statistically significant efficacy (P
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- 2020
10. Mid-flight prey switching in the fringed-lipped bat (Trachops cirrhosus)
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Kernan, Ciara E., Yiambilis, A. N., Searcy, Z. E., Pulica, R. M., Page, R. A., and Caldwell, M. S.
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- 2022
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11. SPICE connection mosaics to link the Sun's surface and the heliosphere
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Varesano, T., primary, Hassler, D.M., additional, Zambrana Prado, N., additional, Plowman, J., additional, Del Zanna, G., additional, Parenti, S., additional, Mason, H.E., additional, Giunta, A., additional, Auchère, F., additional, Carlsson, M., additional, Fludra, A., additional, Peter, H., additional, Müller, D., additional, Williams, D., additional, Aznar Cuadrado, R., additional, Barczynski, K., additional, Buchlin, E., additional, Caldwell, M., additional, Fredvik, T., additional, Grundy, T., additional, Guest, S., additional, Harra, L., additional, Janvier, M., additional, Kucera, T., additional, Leeks, S., additional, Schmutz, W., additional, Schuehle, U., additional, Sidher, S., additional, Teriaca, L., additional, Thompson, W., additional, and Yardley, S.L., additional
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- 2024
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12. Trimester‐specific diagnostic accuracy of ultrasound for detection of placenta accreta spectrum: systematic review and meta‐analysis
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Hessami, K., primary, Horgan, R., additional, Munoz, J. L., additional, Norooznezhad, A. H., additional, Nassr, A. A., additional, Fox, K. A., additional, Di Mascio, D., additional, Caldwell, M., additional, Catania, V., additional, D'Antonio, F., additional, and Abuhamad, A. Z., additional
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- 2024
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13. An investigation into the use of hoof balance metrics to test the reliability of a commonly used foot trimming protocol and their association with biomechanics and pathologies of the equine digit
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Caldwell, M. N., Milner, P., Clegg, P., and Pinchbeck, G.
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636.1 - Abstract
The equine foot has a specific conformation (shape) that provides maximum biomechanical efficiency. Biomechanical efficiency allows the foot to withstand, accept, absorb, dissipate and transmit loading weight bearing forces in a manner that offers the greatest protection to the horse. This principle implies that there is some combination of foot size, foot shape, wall length and angles that make the foot an ideal shock absorbing, weight-bearing structure. It is the proper combination of these variables are said to constitute what has been described as the properly balanced foot. However, there are currently several conflicting hoof balance reference systems commonly utilised and what constitutes ideal balance has been the subject of great debate for many years. One goal of the research was to investigate the principle of equal geometric proportions and dependentcy on factors such as foot-type and environmental conditions. By utilising a standardised trimming protocol and a hoof mapping system to collect measurement data based on proportionality of the bearing border length the purpose of this study was, partly, to verify whether a commonly used theory of hoof balance, firstly described by Duckett, is achieved. Secondly to determine whether geometric proportions are equivalent following trimming, thereby achieving hoof balance. Analysis suggested Currently accepted interpretations of static hoof balance including the achievement of an aligned phalangeal axis and a ground bearing border bisected by CoR are likely to be outmoded. This provides support to the hypothesis that feet should be managed on an individual basis rather than a “one-size fits-all” approach commonly applied and that implementing a prescriptive model may even be counter-productive to the functional integrity of the hoof. Farriery technique have been shown to influence skeletal alignment within the foot. Standardised trimming and shoeing protocols were used to test the hypothesis that shoeing, over an extended period of time, would result in significant differences in static hoof balance proportions. Results showed that horses managed unshod had greater ability to manipulate bearing border length, re-align the heel angle and allow palmar heel migration than shod horses. Furthermore, proportional hoof balance measures were able to be altered in unshod feet and that equivalence of the proportional hoof measures were not present in either cohort (unshod/shod). The significant differences in hoof measures present in shod feet ie; flattening of the sole, heel contraction, reduction in dorsal hoof wall and heel angulation and dorsal migration of dorsal hoof wall and heel seemed likely to reflect the effect of the shoe over an extended period. The application of a standard steel horseshoe appeared to influence hoof shape and is likely to both affect and be affected by mechanical forces acting on the foot. The affect of hoof shape and the mechanical forces experienced by the foot itself following the application of the standardised trimming protocol and the application of a shoe were investigated. Results highlighted significant post-shoeing statistical differences in all dynamic measurements between shod and unshod feet. Specifically post-shoeing reductions in peak pressure and the contact area resulting in differences in peak force and peak force time were noted. These results partially support the propersition of a difference in mechanical behavior of the foot under load and may reflect the differences witnessed in feet under different management regimes. Biomechanical analyses of this kind enable improved understanding of hoof function, and a rational, objective basis for comparing the efficacy of different therapeutic strategies designed to address hoof dysfunction and pathology. There is considerable anecdotal information that poor foot conformation and balance are associated with an increased risk of foot-related lameness but foot imbalance may also result from lameness as an adaptation to chronic pain. Utilising MRI findings from a group of horses referred for lameness investigation bionominal logistic regression was used to test the hypothesis of risk of lameness associated with hoof measurement proportions. There is evidence to suggest a strong correlation between hoof conformation and the biomechanical inference on anatomical structures and foot-related pathologies. Variation in key hoof measurement proportions resulted in significant differences in risk factors of specific common foot pathologies ie; navicular disease and degenerative joint disease of the distal interphalangeal joint. It has been argued that the form of the solar arch was indicative the pathologies. Results from the current study appear to support his hypothesis by linking hoof morphology to the incidence of disease. Whilst the author recognises that hoof shape is influenced by any number of other factors, proportional values along the solar axis may well prove to be a good model for biomechanical efficiency either by trimming alone or form the basis of a more biomechanically sympathetic standardised shoeing model.
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- 2017
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14. Sex-distinct microglial activation and myeloid cell infiltration in the spinal cord after painful peripheral injury
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Nolan A. Huck, Lauren J. Donovan, Huaishuang Shen, Claire E. Jordan, Gabriella P.B. Muwanga, Caldwell M. Bridges, Thomas E. Forman, Stephanie A. Cordonnier, Elena S. Haight, Fiona Dale-Huang, Yoshinori Takemura, and Vivianne L. Tawfik
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Microglia ,TMEM119 ,Complex regional pain syndrome ,Chronic pain ,Sex differences ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Chronic pain is a common and often debilitating problem that affects 100 million Americans. A better understanding of pain’s molecular mechanisms is necessary for developing safe and effective therapeutics. Microglial activation has been implicated as a mediator of chronic pain in numerous preclinical studies; unfortunately, translational efforts using known glial modulators have largely failed, perhaps at least in part due to poor specificity of the compounds pursued, or an incomplete understanding of microglial reactivity. In order to achieve a more granular understanding of the role of microglia in chronic pain as a means of optimizing translational efforts, we utilized a clinically-informed mouse model of complex regional pain syndrome (CRPS), and monitored microglial activation throughout pain progression. We discovered that while both males and females exhibit spinal cord microglial activation as evidenced by increases in Iba1, activation is attenuated and delayed in females. We further evaluated the expression of the newly identified microglia-specific marker, TMEM119, and identified two distinct populations in the spinal cord parenchyma after peripheral injury: TMEM119+ microglia and TMEM119- infiltrating myeloid lineage cells, which are comprised of Ly6G + neutrophils and Ly6G- macrophages/monocytes. Neurons are sensitized by inflammatory mediators released in the CNS after injury; however, the cellular source of these cytokines remains somewhat unclear. Using multiplex in situ hybridization in combination with immunohistochemistry, we demonstrate that spinal cord TMEM119+ microglia are the cellular source of cytokines IL6 and IL1β after peripheral injury. Taken together, these data have important implications for translational studies: 1) microglia remain a viable analgesic target for males and females, so long as duration after injury is considered; 2) the analgesic properties of microglial modulators are likely at least in part related to their suppression of microglial-released cytokines, and 3) a limited number of neutrophils and macrophages/monocytes infiltrate the spinal cord after peripheral injury but have unknown impact on pain persistence or resolution. Further studies to uncover glial-targeted therapeutic interventions will need to consider sex, timing after injury, and the exact target population of interest to have the specificity necessary for translation.
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- 2022
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15. Voice emotion perception and production in cochlear implant users
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Jiam, NT, Caldwell, M, Deroche, ML, Chatterjee, M, and Limb, CJ
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Allied Health and Rehabilitation Science ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Assistive Technology ,Bioengineering ,Rehabilitation ,Prevention ,Clinical Research ,Basic Behavioral and Social Science ,Behavioral and Social Science ,Acoustic Stimulation ,Cochlear Implantation ,Cochlear Implants ,Electric Stimulation ,Emotions ,Humans ,Persons With Hearing Impairments ,Speech Acoustics ,Speech Perception ,Voice Quality ,Voice emotion ,Cochlear implant ,Speech prosody ,Voice emotion production ,Voice emotion perception ,Neurosciences ,Medical Physiology ,Otorhinolaryngology ,Allied health and rehabilitation science ,Biological psychology - Abstract
Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants frequently demonstrate significant difficulty in recognizing voice emotions in comparison to their normal hearing counterparts. Cochlear implant-mediated perception and production of voice emotion is an important but relatively understudied area of research. However, a rich understanding of the voice emotion auditory processing offers opportunities to improve upon CI biomedical design and to develop training programs benefiting CI performance. In this review, we will address the issues, current literature, and future directions for improved voice emotion processing in cochlear implant users.
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- 2017
16. ARIEL payload STOP analysis: a view on the in-flight operational cases for the telescope assembly
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Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Brucalassi, A., Araiza-Durán, J. A., Tozzi, A., Galy, C., Perez, A. G., Caldwell, A., Morgante, G., Bruzzi, D., Caldwell, M., Chioetto, P., Eccleston, P., Fernandez Soler, A. J., Ferruzzi, D., Gottini, D., Lilli, R., Micela, G., Pace, E., Pascale, E., Perez Alvarez, J., Piazzolla, R., Picchi, P., Preti, G., Salatti, M., Scippa, A., Tinetti, G., and Zuppella, P.
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- 2024
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17. Radon backgrounds in the DEAP-1 liquid-argon-based Dark Matter detector
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Amaudruz, P. -A., Batygov, M., Beltran, B., Boudjemline, K., Caldwell, M. G. Boulay B. Cai T., Chen, M., Chouinard, R., Cleveland, B. T., Contreras, D., Dering, K., Duncan, F., Ford, R., Giuliani, R. Gagnon F., Golovko, M. Gold V. V., Gorel, P., Graham, K., Grant, D. R., Hakobyan, R., Hallin, A. L., Harvey, P., Hearns, C., Jillings, C. J., Kuźniak, M., Lawson, I., Li, O., Lidgard, J., Liimatainen, P., Lippincott, W. H., Mathew, R., McDonald, A. B., McElroy, T., McFarlane, K., McKinsey, D., Muir, A., Nantais, C., Nicolics, K., Nikkel, J., Noble, T., O'Dwyer, E., Olsen, K. S., Ouellet, C., Pasuthip, P., Pollmann, T., Rau, W., Retiere, F., Ronquest, M., Skensved, P., Sonley, T., Tang, J., Vázquez-Jáuregui, E., Veloce, L., and Ward, M.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Nuclear Experiment ,Physics - Instrumentation and Detectors - Abstract
The DEAP-1 \SI{7}{kg} single phase liquid argon scintillation detector was operated underground at SNOLAB in order to test the techniques and measure the backgrounds inherent to single phase detection, in support of the \mbox{DEAP-3600} Dark Matter detector. Backgrounds in DEAP are controlled through material selection, construction techniques, pulse shape discrimination and event reconstruction. This report details the analysis of background events observed in three iterations of the DEAP-1 detector, and the measures taken to reduce them. The $^{222}$Rn decay rate in the liquid argon was measured to be between 16 and \SI{26}{\micro\becquerel\per\kilogram}. We found that the background spectrum near the region of interest for Dark Matter detection in the DEAP-1 detector can be described considering events from three sources: radon daughters decaying on the surface of the active volume, the expected rate of electromagnetic events misidentified as nuclear recoils due to inefficiencies in the pulse shape discrimination, and leakage of events from outside the fiducial volume due to imperfect position reconstruction. These backgrounds statistically account for all observed events, and they will be strongly reduced in the DEAP-3600 detector due to its higher light yield and simpler geometry.
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- 2012
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18. The Herschel-SPIRE instrument and its in-flight performance
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Griffin, M. J., Abergel, A., Abreu, A., Ade, P. A. R., André, P., Augueres, J. -L., Babbedge, T., Bae, Y., Baillie, T., Baluteau, J. -P., Barlow, M. J., Bendo, G., Benielli, D., Bock, J. J., Bonhomme, P., Brisbin, D., Brockley-Blatt, C., Caldwell, M., Cara, C., Castro-Rodriguez, N., Cerulli, R., Chanial, P., Chen, S., Clark, E., Clements, D. L., Clerc, L., Coker, J., Communal, D., Conversi, L., Cox, P., Crumb, D., Cunningham, C., Daly, F., Davis, G. R., De Antoni, P., Delderfield, J., Devin, N., Di Giorgio, A., Didschuns, I., Dohlen, K., Donati, M., Dowell, A., Dowell, C. D., Duband, L., Dumaye, L., Emery, R. J., Ferlet, M., Ferrand, D., Fontignie, J., Fox, M., Franceschini, A., Frerking, M., Fulton, T., Garcia, J., Gastaud, R., Gear, W. K., Glenn, J., Goizel, A., Griffin, D. K., Grundy, T., Guest, S., Guillemet, L., Hargrave, P. C., Harwit, M., Hastings, P., Hatziminaoglou, E., Herman, M., Hinde, B., Hristov, V., Huang, M., Imhof, P., Isaak, K. J., Israelsson, U., Ivison, R. J., Jennings, D., Kiernan, B., King, K. J., Lange, A. E., Latter, W., Laurent, G., Laurent, P., Leeks, S. J., Lellouch, E., Levenson, L., Li, B., Li, J., Lilienthal, J., Lim, T., Liu, J., Lu, N., Madden, S., Mainetti, G., Marliani, P., McKay, D., Mercier, K., Molinari, S., Morris, H., Moseley, H., Mulder, J., Mur, M., Naylor, D. A., Nguyen, H., O'Halloran, B., Oliver, S., Olofsson, G., Olofsson, H. -G., Orfei, R., Page, M. J., Pain, I., Panuzzo, P., Papageorgiou, A., Parks, G., Parr-Burman, P., Pearce, A., Pearson, C., Pérez-Fournon, I., Pinsard, F., Pisano, G., Podosek, J., Pohlen, M., Polehampton, E. T., Pouliquen, D., Rigopoulou, D., Rizzo, D., Roseboom, I. G., Roussel, H., Rowan-Robinson, M., Rownd, B., Saraceno, P., Sauvage, M., Savage, R., Savini, G., Sawyer, E., Scharmberg, C., Schmitt, D., Schneider, N., Schulz, B., Schwartz, A., Shafer, R., Shupe, D. L., Sibthorpe, B., Sidher, S., Smith, A., Smith, A. J., Smith, D., Spencer, L., Stobie, B., Sudiwala, R., Sukhatme, K., Surace, C., Stevens, J. A., Swinyard, B. M., Trichas, M., Tourette, T., Triou, H., Tseng, S., Tucker, C., Turner, A., Vaccari, M., Valtchanov, I., Vigroux, L., Virique, E., Voellmer, G., Walker, H., Ward, R., Waskett, T., Weilert, M., Wesson, R., White, G. J., Whitehouse, N., Wilson, C. D., Winter, B., Woodcraft, A. L., Wright, G. S., Xu, C. K., Zavagno, A., Zemcov, M., Zhang, L., and Zonca, E.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Spectral and Photometric Imaging Receiver (SPIRE), is the Herschel Space Observatory`s submillimetre camera and spectrometer. It contains a three-band imaging photometer operating at 250, 350 and 500 microns, and an imaging Fourier Transform Spectrometer (FTS) which covers simultaneously its whole operating range of 194-671 microns (447-1550 GHz). The SPIRE detectors are arrays of feedhorn-coupled bolometers cooled to 0.3 K. The photometer has a field of view of 4' x 8', observed simultaneously in the three spectral bands. Its main operating mode is scan-mapping, whereby the field of view is scanned across the sky to achieve full spatial sampling and to cover large areas if desired. The spectrometer has an approximately circular field of view with a diameter of 2.6'. The spectral resolution can be adjusted between 1.2 and 25 GHz by changing the stroke length of the FTS scan mirror. Its main operating mode involves a fixed telescope pointing with multiple scans of the FTS mirror to acquire spectral data. For extended source measurements, multiple position offsets are implemented by means of an internal beam steering mirror to achieve the desired spatial sampling and by rastering of the telescope pointing to map areas larger than the field of view. The SPIRE instrument consists of a cold focal plane unit located inside the Herschel cryostat and warm electronics units, located on the spacecraft Service Module, for instrument control and data handling. Science data are transmitted to Earth with no on-board data compression, and processed by automatic pipelines to produce calibrated science products. The in-flight performance of the instrument matches or exceeds predictions based on pre-launch testing and modelling: the photometer sensitivity is comparable to or slightly better than estimated pre-launch, and the spectrometer sensitivity is also better by a factor of 1.5-2., Comment: Accepted for publication in Astronomy & Astrophyics (Herschel first results special issue)
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- 2010
- Full Text
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19. A multiple spacecraft detection of the 2 April 2022 M-class flare and filament eruption during the first close Solar Orbiter perihelion
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Janvier, M., primary, Mzerguat, S., additional, Young, P. R., additional, Buchlin, É., additional, Manou, A., additional, Pelouze, G., additional, Long, D. M., additional, Green, L., additional, Warmuth, A., additional, Schuller, F., additional, Démoulin, P., additional, Calchetti, D., additional, Kahil, F., additional, Bellot Rubio, L., additional, Parenti, S., additional, Baccar, S., additional, Barczynski, K., additional, Harra, L. K., additional, Hayes, L. A., additional, Thompson, W. T., additional, Müller, D., additional, Baker, D., additional, Yardley, S., additional, Berghmans, D., additional, Verbeeck, C., additional, Smith, P. J., additional, Peter, H., additional, Aznar Cuadrado, R., additional, Musset, S., additional, Brooks, D. H., additional, Rodríguez, L., additional, Auchère, F., additional, Carlsson, M., additional, Fludra, A., additional, Hassler, D., additional, Williams, D., additional, Caldwell, M., additional, Fredvik, T., additional, Giunta, A., additional, Grundy, T., additional, Guest, S., additional, Kraaikamp, E., additional, Leeks, S., additional, Plowman, J., additional, Schmutz, W., additional, Schühle, U., additional, Sidher, S. D., additional, Teriaca, L., additional, Solanki, S. K., additional, del Toro Iniesta, J. C., additional, Woch, J., additional, Gandorfer, A., additional, Hirzberger, J., additional, Orozco Suárez, D., additional, Appourchaux, T., additional, Valori, G., additional, Sinjan, J., additional, Albert, K., additional, and Volkmer, R., additional
- Published
- 2023
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20. Application of scanning ion conductance microscopy to localised patch clamp recording from presynaptic terminals
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Caldwell, M. B.
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572 - Abstract
The spatial distribution of ion channels in different subcellular regions is a key determinant of neuronal behaviour. Patch clamp electrophysiology allows characterisation of ion channel activity, but precise localisation is more difficult. This is particularly true for very small, specialised compartments such as synaptic terminals, which are inaccessible by conventional, direct patch recording methods. Scanning ion conductance microscopy (SICM) generates high resolution topographic images by using a precisely positioned probe to measure ion currents. The development of a new ‘hopping’ mode allows convoluted neuronal networks to be imaged using the SICM probe. Some details of the implementation of this mode are described. The geometry of SICM pipette tips is examined, and the interaction between the probe and the cell membrane is shown to differ from the standard account. Application of SICM to localised patch clamp recording has previously been demonstrated in several cell types and here is extended to record from presynaptic sites. Control experiments are performed and a model is introduced to explain how the use of fine-tipped SICM pipettes may give rise to artefacts seen in some of these experiments. The technique is then applied to synaptic boutons in primary cerebellar culture and a number of successful recordings are presented, along with some attempts to combine the advantages of SICM positioning with those of more conventional patch clamp pipettes. Experimental limitations of these approaches are discussed.
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- 2012
21. Cellular fitness in response to oncogenic Kras
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Caldwell, M. E.
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616.994 - Abstract
Here it is shown that the sequences that occurs during the development of pancreatic ductal adenocarcinoma is balanced by an equally abundant proliferative rate, suggesting that small perturbations that promote or impede proliferation may determine the rate of tumour progression. Furthermore, engagement of the MAP kinase pathway corresponds to enhanced cellular proliferation in pancreatic preneoplasms, providing a mechanistic basis for senescence avoidance. A p53-dependent cell autonomous barrier exists, but the complexity of this process is currently underappreciated as cellular fitness in pancreatic preneoplasms is governed by a multitude of parameters in vivo. In addition to the requisite genetic alterations, specific cellular behaviours must be during tumourigenesis and it is these behaviours that are ultimately representative of the pathological nature of the disease. Understanding how each genetic alteration directly influences cellular behaviours and the mechanisms that enable this has provided insight into the earliest stages of tumour development, prior to actual derangement of phenotypically wild type cells. This thesis seeks to demonstrate what the earliest behavioural changes are in response to endogenous expression of oncogenic Kras and how those acute responses enable extrapolation into eventual tumourigenesis or lack thereof. Based upon these results, we propose that pancreatic ductal cells are the likely cell of origin for ductal pancreatic cancer.
- Published
- 2011
22. AI-enabled future crime
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Caldwell, M., Andrews, J. T. A., Tanay, T., and Griffin, L. D.
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- 2020
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23. Rapid Soil Moisture Recharge to Depth by Roots in a Stand of Artemisia tridentata
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Ryel, R. J., Caldwell, M. M., Leffler, A. J., and Yoder, C. K.
- Published
- 2003
24. Simulation of Preterm Neonatal Brain Metabolism During Functional Neuronal Activation Using a Computational Model
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Hapuarachchi, T., Scholkmann, F., Caldwell, M., Hagmann, C., Kleiser, S., Metz, A. J., Pastewski, M., Wolf, M., Tachtsidis, I., Elwell, Clare E., editor, Leung, Terence S., editor, and Harrison, David K., editor
- Published
- 2016
- Full Text
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25. Hydraulic Redistribution in a Stand of Artemisia tridentata: Evaluation of Benefits to Transpiration Assessed with a Simulation Model
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Ryel, R. J., Caldwell, M. M., Yoder, C. K., and Leffler, A. J.
- Published
- 2002
26. Nutrient Acquisition from Soils with Patchy Nutrient Distributions as Assessed with Simulation Models
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Ryel, R. J. and Caldwell, M. M.
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- 1998
- Full Text
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27. Swimming-Associated Haemorrhagic Colitis Due to Escherichia coli 0157:H7 Infection: Evidence of Prolonged Contamination of a Fresh Water Lake
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Ackman, D., Marks, S., Mack, P., and Caldwell, M.
- Published
- 1997
28. Newly Repopulated Spinal Cord Microglia Exhibit A Unique Transcriptome And Coincide With Sex-Independent Pain Resolution
- Author
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Bridges, Caldwell M., primary, Donovan, Lauren J., additional, Nippert, Amy R., additional, Wang, Meng, additional, Wu, Shaogen, additional, Forman, Thomas E., additional, Haight, Elena S., additional, Huck, Nolan A., additional, Jordan, Claire E., additional, Gardner, Aysha S., additional, Nair, Ramesh V., additional, and Tawfik, Vivianne L., additional
- Published
- 2023
- Full Text
- View/download PDF
29. Childhood Trauma Predicts Sadistic Traits and Violent Behavior in Incarcerated Youth
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Cazala, F., primary, Sajous-Turner, A., additional, Caldwell, M. F., additional, Van Rybroek, G. J., additional, Kiehl, K. A., additional, and Harenski, C. L., additional
- Published
- 2023
- Full Text
- View/download PDF
30. Shading Reduces Exploitation of Soil Nitrate and Phosphate by Agropyron desertorum and Artemisia tridentata from Soils with Patchy and Uniform Nutrient Distributions
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Caldwell, M. M.
- Published
- 1997
31. Integrating Resource Heterogeneity and Plant Plasticity: Modelling Nitrate and Phosphate Uptake in a Patchy Soil Environment
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Jackson, R. B. and Caldwell, M. M.
- Published
- 1996
- Full Text
- View/download PDF
32. Large language models respond to influence like humans
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Griffin, L., Kleinberg, B., Mozes, M., Mai, K., Vau, M.D.M., Caldwell, M., Mavor-Parker, A., Griffin, L., Kleinberg, B., Mozes, M., Mai, K., Vau, M.D.M., Caldwell, M., and Mavor-Parker, A.
- Abstract
Two studies tested the hypothesis that a Large Language Model (LLM) can be used to model psychological change following exposure to influential input. The first study tested a generic mode of influence - the Illusory Truth Effect (ITE) - where earlier exposure to a statement boosts a later truthfulness test rating. Analysis of newly collected data from human and LLM-simulated subjects (1000 of each) showed the same pattern of effects in both populations; although with greater per statement variability for the LLM. The second study concerns a specific mode of influence – populist framing of news to increase its persuasion and political mobilization. Newly collected data from simulated subjects was compared to previously published data from a 15 country experiment on 7286 human participants. Several effects from the human study were replicated by the simulated study, including ones that surprised the authors of the human study by contradicting their theoretical expectations; but some significant relationships found in human data were not present in the LLM data. Together the two studies support the view that LLMs have potential to act as models of the effect of influence.
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- 2023
33. Newly repopulated spinal cord microglia exhibit a unique transcriptome and coincide with sex-independent pain resolution
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Donovan, Lauren J., primary, Bridges, Caldwell M., additional, Nippert, Amy R., additional, Wang, Meng, additional, Wu, Shaogen, additional, Forman, Thomas E., additional, Haight, Elena S., additional, Huck, Nolan A., additional, Jordan, Claire E., additional, Gardner, Aysha S., additional, Nair, Ramesh V., additional, and Tawfik, Vivianne L., additional
- Published
- 2022
- Full Text
- View/download PDF
34. Newly repopulated spinal cord microglia exhibit a unique transcriptome and correlate with pain resolution
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Lauren J. Donovan, Caldwell M. Bridges, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Sabrina F. Bond, Claire E. Jordan, Aysha S. Gardner, Ramesh V. Nair, and Vivianne L. Tawfik
- Abstract
SummaryMicroglia contribute to the initiation of pain, however, a translationally viable approach addressing how or when to modulate these cells remains elusive. We used a targeted, inducible, genetic microglial depletion strategy at both acute and acute-to-chronic transition phases in the clinically-relevant tibial fracture/casting pain model to determine the contribution of microglia to the initiation and maintenance of pain. We observed complete resolution of pain after transient microglial depletion at the acute-to-chronic phase, which coincided with the timeframe of full repopulation of microglia. These repopulated microglia were morphologically distinct from control microglia, signifying they may exhibit a unique transcriptome. RNA sequencing of repopulated spinal cord microglia identified genes of interest using weighted gene co-expression network analysis (WGCNA). We intersected these genes with a newly-generated single nuclei microglial dataset from human spinal cord dorsal horn and identified human-relevant genes that may ultimately promote pain resolution after injury. This work presents a novel approach to gene discovery in pain and provides comprehensive datasets for the development of future microglial-targeted therapeutics.
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- 2022
35. Newly Repopulated Spinal Cord Microglia Exhibit A Unique Transcriptome And Coincide With Sex-Independent Pain Resolution
- Author
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Caldwell M. Bridges, Lauren J. Donovan, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Claire E. Jordan, Aysha S. Gardner, Ramesh V. Nair, and Vivianne L. Tawfik
- Subjects
Anesthesiology and Pain Medicine ,Neurology ,Neurology (clinical) - Published
- 2023
36. Sex-distinct microglial activation and myeloid cell infiltration in the spinal cord after painful peripheral injury
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Huck, Nolan A., primary, Donovan, Lauren J., additional, Shen, Huaishuang, additional, Jordan, Claire E., additional, Muwanga, Gabriella P.B., additional, Bridges, Caldwell M., additional, Forman, Thomas E., additional, Cordonnier, Stephanie A., additional, Haight, Elena S., additional, Dale-Huang, Fiona, additional, Takemura, Yoshinori, additional, and Tawfik, Vivianne L., additional
- Published
- 2022
- Full Text
- View/download PDF
37. Downward Flux of Water through Roots (i.e. Inverse Hydraulic Lift) in Dry Kalahari Sands
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Caldwell, M. M., Canadell, J., Mooney, H. A., Jackson, R. B., Parson, D., Sala, O. E., and Trimborn, P.
- Published
- 1998
38. Solar ultraviolet radiation and ozone depletion-driven climate change: effects on terrestrial ecosystems
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Bornman, J. F., Barnes, P. W., Robinson, S. A., Ballaré, C. L., Flint, S. D., and Caldwell, M. M.
- Published
- 2015
- Full Text
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39. Mitigating Local Causes of Ocean Acidification with Existing Laws
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Kelly, R. P., Foley, M. M., Fisher, W. S., Feely, R. A., Halpern, B. S., Waldbusser, G. G., and Caldwell, M. R.
- Published
- 2011
- Full Text
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40. Randomized trial of pragmatic education for low-risk COPD patients: impact on hospitalizations and emergency department visits
- Author
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Siddique HH, Olson RH, Parenti CM, Rector TS, Caldwell M, Dewan NA, and Rice KL
- Subjects
Diseases of the respiratory system ,RC705-779 - Abstract
Haamid H Siddique,1 Raymond H Olson,2 Connie M Parenti,2 Thomas S Rector,2 Michael Caldwell,3 Naresh A Dewan,3 Kathryn L Rice21University of Wisconsin Hospital and Clinics, Madison, WI; 2Minneapolis Veterans Affairs Health Care Center, Minneapolis, MN; 3Omaha Veterans Affairs Health Care Center, Omaha VA Nebraska-Western, Iowa Health Care System, Omaha, NE, USABackground: Most interventions aimed at reducing hospitalizations and emergency department (ED) visits in patients with chronic obstructive pulmonary disease (COPD) have employed resource-intense programs in high-risk individuals. Although COPD is a progressive disease, little is known about the effectiveness of proactive interventions aimed at preventing hospitalizations and ED visits in the much larger population of low-risk (no known COPD-related hospitalizations or ED visits in the prior year) patients, some of whom will eventually become high-risk.Methods: We tested the effect of a simple educational and self-efficacy intervention (n = 2243) versus usual care (n = 2182) on COPD/breathing-related ED visits and hospitalizations in a randomized study of low-risk patients at three Veterans Affairs (VA) medical centers in the upper Midwest. Administrative data was used to track VA admissions and ED visits. A patient survey was used to determine health-related events outside the VA.Results: Rates of COPD-related VA hospitalizations in the education and usual care group were not significantly different (3.4 versus 3.6 admissions per 100 person-years, respectively; 95% CI of difference -1.3 to 1.0, P = 0.77). The much higher patient-reported rates of non-VA hospitalizations for breathing-related problems were lower in the education group (14.0 versus 19.0 per 100 person-years; 95% CI -8.6 to -1.4, P = 0.006). Rates of COPD-related VA ED visits were not significantly different (6.8 versus 5.3; 95% CI -0.1 to 3.0, P = 0.07), nor were non-VA ED visits (32.4 versus 36.5; 95% CI -9.3 to 1.1, P = 0.12). All-cause VA admission and ED rates did not differ. Mortality rates (6.9 versus 8.3 per 100 person-years, respectively; 95% CI -3.0 to 0.4, P = 0.13) did not differ.Conclusion: An educational intervention that is practical for large numbers of low-risk patients with COPD may reduce the rate of breathing-related hospitalizations. Further research that more closely tracks hospitalizations to non-VA facilities is needed to confirm this finding.Keywords: chronic obstructive pulmonary disease, education, disease management, self-efficacy
- Published
- 2012
41. In the News
- Author
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Chaber, A.-L., Lamb, M. P., Fonstad, M. A., Gartrell, N., Bos, H., Crowder, D. W., Caldwell, M. S., Bloch, G., and Poliseno, L.
- Published
- 2010
42. Chemical Composition Analysis and Product Consistency Tests of the ORP Phase 5 Nepheline Study Glasses
- Author
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Fox, K. M., primary, Edwards, T. B., additional, Caldwell, M. E., additional, and Riley, W. T., additional
- Published
- 2018
- Full Text
- View/download PDF
43. Sulfur Solubility Testing and Characterization of Hanford LAW Phase 2, Inner Layer Matrix Glasses
- Author
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Fox, K. M., primary, Edwards, T. B., additional, Caldwell, M. E., additional, and Riley, W. T., additional
- Published
- 2017
- Full Text
- View/download PDF
44. Overview: Perspectives in Ecophysiological Research of Photosynthesis
- Author
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Schulze, E.-D., Caldwell, M. M., Schulze, Ernst-Detlef, editor, and Caldwell, Martyn M., editor
- Published
- 1995
- Full Text
- View/download PDF
45. Photosynthesis of Vascular Plants: Assessing Canopy Photosynthesis by Means of Simulation Models
- Author
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Beyschlag, W., Ryel, R. J., Caldwell, M. M., Schulze, Ernst-Detlef, editor, and Caldwell, Martyn M., editor
- Published
- 1995
- Full Text
- View/download PDF
46. First observations from the SPICE EUV spectrometer on Solar Orbiter
- Author
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Fludra, A., primary, Caldwell, M., additional, Giunta, A., additional, Grundy, T., additional, Guest, S., additional, Leeks, S., additional, Sidher, S., additional, Auchère, F., additional, Carlsson, M., additional, Hassler, D., additional, Peter, H., additional, Aznar Cuadrado, R., additional, Buchlin, É., additional, Caminade, S., additional, DeForest, C., additional, Fredvik, T., additional, Haberreiter, M., additional, Harra, L., additional, Janvier, M., additional, Kucera, T., additional, Müller, D., additional, Parenti, S., additional, Schmutz, W., additional, Schühle, U., additional, Solanki, S. K., additional, Teriaca, L., additional, Thompson, W. T., additional, Tustain, S., additional, Williams, D., additional, Young, P. R., additional, and Chitta, L. P., additional
- Published
- 2021
- Full Text
- View/download PDF
47. A histological investigation of mosasaur dental crown characters
- Author
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Street, H. P., LeBlanc, Aaron, and Caldwell, M. W.
- Abstract
Mosasaur researchers have used varieties of tooth crown ornamentation as diagnostic and phylogenetic characters for decades. Such tooth crown features include facets, flutes, striations, serrated carinae, and coarse anastomosing texture. This study investigates the relative contribution of dentine and enamel to the development of these dental characters and assesses possible homologies between these structures. Histological analysis of isolated mosasaur teeth revealed that flutes and facets develop initially from the dentine, and the external enamel morphology we observe macroscopically mirrors the shape the underlying dentine. Striations combine underlying contributions from the dentine with additional and irregular enamel deposition that results strictly from amelogenesis. In both serrated carinae and anastomosing texture the border between the dentine and the enamel is smooth, and these external ornamentations form through variations in enamel development. Based on these observations, we infer that flutes and facets are part of a morphological spectrum and should not be treated as separate phylogenetic characters. Conversely, striations develop differently than flutes and facets, and should therefore be treated as a distinct character. We recommend referring to the “serrations” on mosasaur carinae as crenulations to differentiate these enamel-only structures from true denticles possessing a dentine core. Anastomosing texture can also coincide with significant apical thickening, both of which could be adaptations for processing hard-shelled prey. Care must be taken when using tooth crown features as diagnostic or phylogenetic characters because seemingly different morphologies can have similar developmental origins, and tooth morphology can be more closely tied to diet than to common ancestry.
- Published
- 2021
48. THE GEOSTATIONARY EARTH RADIATION BUDGET PROJECT
- Author
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Harries, J. E., Russell, J. E., Hanafin, J. A., Brindley, H., Futyan, J., Rufus, J., Kellock, S., Matthews, G., Wrigley, R., Last, A., Mueller, J., Mossavati, R., Ashmall, J., Sawyer, E., Parker, D., Caldwell, M., Allan, P. M., Smith, A., Bates, M. J., Coan, B., Stewart, B. C., Lepine, D. R., Cornwall, L. A., Corney, D. R., Ricketts, M. J., Drummond, D., Smart, D., Cutler, R., Dewitte, S., Clerbaux, N., Gonzalez, L., Ipe, A., Bertrand, C., Joukoff, A., Crommelynck, D., Nelms, N., Llewellyn-Jones, D. T., Butcher, G., Smith, G. L., Szewczyk, Z. P., Mlynczak, P. E., Slingo, A., Allan, R. P., and Ringer, M. A.
- Published
- 2005
49. Comparative plasma pharmacokinetics of ceftiofur sodium and ceftiofur crystalline-free acid in neonatal calves
- Author
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Woodrow, J. S., Caldwell, M., Cox, S., Hines, M., and Credille, B. C.
- Published
- 2016
- Full Text
- View/download PDF
50. Training and Education.
- Author
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Delaware State Coll., Dover. Dept. of Education. and Caldwell, M. Milford
- Abstract
This article described a preservice elementary teacher education program at Delaware State College initiated in 1969. The proposed objectives of the program included 1) an improved program for training teachers, 2) an opportunity for more agencies to be involved in teacher training, 3) a program geared to minority groups who in the past have been a high risk potential, and 4) a training program which would be a model to recommend changes in the present teacher program at the college. The program was divided into three overlapping parts: field experience, content, and professional education. All courses relating to these segments were presented along with course load schedules for average and exceptional students. A high school diploma was not a requirement for entrance into the program. Tutoring and counseling services were initiated for the students and the Teach-Test-Reteach (T-T-Rt) method of teaching was applied. The requirements of teacher selection focused on the ability of the teacher to communicate with the participants. The program was designed to meet training needs of the participants and the present day needs of the classroom teacher. (BRB)
- Published
- 1969
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