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3. Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry

Author

Kelly, Meagan, Mandlik, Anjali, Charles, Richelle C., Verma, Smriti, Calderwood, Stephen B., Leung, Daniel T., Biswas, Rajib, Islam, Kamrul, Kamruzzaman, Mohammad, Chowdhury, Fahima, Khanam, Farhana, Vann, Willie F., Khan, Ashraful Islam, Bhuiyan, Taufiqur Rahman, Qadri, Firdausi, Vortherms, Anthony R., Kaminski, Robert, Kováč, Pavol, Xu, Peng, and Ryan, Edward T.

Published
2023
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4. Seroprevalence of SARS-CoV-2 antibodies in Bangladesh related to novel coronavirus infection

Author

Bhuiyan, Taufiqur Rahman, Akhtar, Marjahan, Akter, Aklima, Khaton, Fatema, Rahman, Sadia Isfat Ara, Ferdous, Jannatul, Nazneen, Arifa, Sumon, Shariful Amin, Banik, Kajal C., Bablu, Arifur Rahman, Alamgir, A.S.M., Rahman, Mahbubur, Tony, Selim Reza, Hossain, Khaled, Calderwood, Stephen B., Charles, Richelle C., Ryan, Edward T., LaRocque, Regina C., Harris, Jason B., Rahman, Mustafizur, Chakraborty, Nitai, Rahman, Mahmudur, Arifeen, Shams El, Flora, Meerjady Sabrina, Shirin, Tahmina, Banu, Sayera, and Qadri, Firdausi

Published
2022
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5. Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh

Author

Charles, Richelle C, Nakajima, Rie, Liang, Li, Jasinskas, Al, Berger, Amanda, Leung, Daniel T, Kelly, Meagan, Xu, Peng, Kováč, Pavol, Giffen, Samantha R, Harbison, James D, Chowdhury, Fahima, Khan, Ashraful I, Calderwood, Stephen B, Bhuiyan, Taufiqur Rahman, Harris, Jason B, Felgner, Philip L, Qadri, Firdausi, and Ryan, Edward T

Subjects
Foodborne Illness, Infectious Diseases, Vaccine Related, Prevention, Clinical Research, Biodefense, Emerging Infectious Diseases, Digestive Diseases, Immunization, Good Health and Well Being, Adolescent, Adult, Antibodies, Bacterial, Antibody Formation, Bangladesh, Case-Control Studies, Cholera, Cholera Toxin, Female, Flagellin, Humans, Immunity, Mucosal, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Leukocytes, Mononuclear, Male, Middle Aged, Mucous Membrane, O Antigens, Phosphoenolpyruvate Sugar Phosphotransferase System, Phosphotransferases (Nitrogenous Group Acceptor), Reproducibility of Results, Vibrio cholerae O1, Vibrio cholerae O139, Young Adult, cholera, Vibrio, cholerae, immunogenic, OSP, sialidase, HlyA, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundCholera is a severe dehydrating illness of humans caused by toxigenic strains of Vibrio cholerae O1 or O139. Identification of immunogenic V. cholerae antigens could lead to a better understanding of protective immunity in human cholera.MethodsWe probed microarrays containing 3652 V. cholerae antigens with plasma and antibody-in-lymphocyte supernatant (ALS, a surrogate marker of mucosal immune responses) from patients with severe cholera caused by V. cholerae O1 in Bangladesh and age-, sex-, and ABO-matched Bangladeshi controls. We validated a subset of identified antigens using enzyme-linked immunosorbent assay.ResultsOverall, we identified 608 immunoreactive V. cholerae antigens in our screening, 59 of which had higher immunoreactivity in convalescent compared with acute-stage or healthy control samples (34 in plasma, 39 in mucosal ALS; 13 in both sample sets). Identified antigens included cholera toxin B and A subunits, V. cholerae O-specific polysaccharide and lipopolysaccharide, toxin coregulated pilus A, sialidase, hemolysin A, flagellins (FlaB, FlaC, and FlaD), phosphoenolpyruvate-protein phosphotransferase, and diaminobutyrate-2-oxoglutarate aminotransferase.ConclusionsThis study is the first antibody profiling of the mucosal and systemic antibody responses to the nearly complete V. cholerae O1 protein immunome; it has identified antigens that may aid in the development of an improved cholera vaccine.

Published
2017

6. Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells

Author

Kauffman, Robert C, Bhuiyan, Taufiqur R, Nakajima, Rie, Mayo-Smith, Leslie M, Rashu, Rasheduzzaman, Hoq, Mohammad Rubel, Chowdhury, Fahima, Khan, Ashraful Islam, Rahman, Atiqur, Bhaumik, Siddhartha K, Harris, Levelle, O'Neal, Justin T, Trost, Jessica F, Alam, Nur Haq, Jasinskas, Algis, Dotsey, Emmanuel, Kelly, Meagan, Charles, Richelle C, Xu, Peng, Kováč, Pavol, Calderwood, Stephen B, Ryan, Edward T, Felgner, Phillip L, Qadri, Firdausi, Wrammert, Jens, Harris, Jason B, Petri, William, Kaper, James, and Sack, David

Subjects
Biodefense, Clinical Research, Vaccine Related, Foodborne Illness, Prevention, Biotechnology, Immunization, Emerging Infectious Diseases, Infectious Diseases, Digestive Diseases, Infection, Good Health and Well Being, Adult, Antibodies, Bacterial, Antibodies, Monoclonal, Antibody Formation, B-Lymphocytes, Bacterial Toxins, Cholera, Cholera Toxin, Cross Reactions, Enterotoxins, Escherichia coli Proteins, Humans, Immunologic Memory, Lipopolysaccharides, Neuraminidase, O Antigens, Proteomics, Serogroup, Single-Cell Analysis, Vibrio cholerae, Microbiology
Abstract

We characterized the acute B cell response in adults with cholera by analyzing the repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. We found that the cholera-induced responses were characterized by high levels of somatic hypermutation and large clonal expansions. A majority of the expansions targeted cholera toxin (CT) or lipopolysaccharide (LPS). Using a novel proteomics approach, we were able to identify sialidase as another major antigen targeted by the antibody response to Vibrio cholerae infection. Antitoxin MAbs targeted both the A and B subunits, and most were also potent neutralizers of enterotoxigenic Escherichia coli heat-labile toxin. LPS-specific MAbs uniformly targeted the O-specific polysaccharide, with no detectable responses to either the core or the lipid moiety of LPS. Interestingly, the LPS-specific antibodies varied widely in serotype specificity and functional characteristics. One participant infected with the Ogawa serotype produced highly mutated LPS-specific antibodies that preferentially bound the previously circulating Inaba serotype. This demonstrates durable memory against a polysaccharide antigen presented at the mucosal surface and provides a mechanism for the long-term, partial heterotypic immunity seen following cholera.ImportanceCholera is a diarrheal disease that results in significant mortality. While oral cholera vaccines are beneficial, they do not achieve equivalent protection compared to infection with Vibrio cholerae Although antibodies likely mediate protection, the mechanisms of immunity following cholera are poorly understood, and a detailed understanding of antibody responses to cholera is of significance for human health. In this study, we characterized the human response to cholera at the single-plasmablast, monoclonal antibody level. Although this approach has not been widely applied to the study of human bacterial infection, we were able to uncover the basis of cross-reactivity between different V. cholerae serotypes and the likely impact of prior enterotoxigenic Escherichia coli exposure on the response to cholera, as well as identify novel antigenic targets. In addition to improving our understanding of the repertoire and function of the antibody response to cholera in humans, this study has implications for future cholera vaccination efforts.

Published
2016

8. Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh

Author

Shirin, Tahmina, Bhuiyan, Taufiqur Rahman, Charles, Richelle C., Amin, Shaheena, Bhuiyan, Imran, Kawser, Zannat, Rahat, Asifuzaman, Alam, Ahmed Nawsher, Sultana, Sharmin, Aleem, Md Abdul, Khan, Manjur Hossain, Khan, Samsad Rabbani, LaRocque, Regina C., Calderwood, Stephen B., Ryan, Edward T., Slater, Damien M., Banu, Sayera, Clemens, John, Harris, Jason B., Flora, Meerjady Sabrina, and Qadri, Firdausi

Published
2020
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9. Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans

Author

David, Lawrence A, Weil, Ana, Ryan, Edward T, Calderwood, Stephen B, Harris, Jason B, Chowdhury, Fahima, Begum, Yasmin, Qadri, Firdausi, LaRocque, Regina C, and Turnbaugh, Peter J

Subjects
Genetics, Emerging Infectious Diseases, Human Genome, Biodefense, Infectious Diseases, Foodborne Illness, Vaccine Related, Prevention, Digestive Diseases, Biotechnology, Infection, Good Health and Well Being, Cholera, Diarrhea, Enterotoxigenic Escherichia coli, Escherichia coli Infections, Gastrointestinal Microbiome, Gastrointestinal Tract, Humans, Metagenomics, Vibrio cholerae, Microbiology
Abstract

UnlabelledDisability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities respond to diarrheal disease and its treatment. Here, we report that after Vibrio cholerae infection, the human gut microbiota undergoes an orderly and reproducible succession that features transient reversals in relative levels of enteric Bacteroides and Prevotella. Elements of this succession may be a common feature in microbiota recovery from acute secretory diarrhea, as we observed similar successional dynamics after enterotoxigenic Escherichia coli (ETEC) infection. Our metagenomic analyses suggest that multiple mechanisms drive microbial succession after cholera, including bacterial dispersal properties, changing enteric oxygen and carbohydrate levels, and phage dynamics. Thus, gut microbiota recovery after cholera may be predictable at the level of community structure but is driven by a complex set of temporally varying ecological processes. Our findings suggest opportunities for diagnostics and therapies targeting the gut microbiota in humans recovering from infectious diarrhea.ImportanceDisability after diarrhea is a major burden on public health in the developing world. Gut bacteria may affect this recovery, but it remains incompletely understood how resident microbes in the digestive tract respond to diarrheal illness. Here, we observed an orderly and reproducible succession of gut bacterial groups after cholera in humans. Genomic analyses associated the succession with bacterial dispersal in food, an altered microbial environment, and changing phage levels. Our findings suggest that it may one day be feasible to manage resident bacterial populations in the gut after infectious diarrhea.

Published
2015

11. Cholera toxin and O-specific polysaccharide immune responses after oral cholera vaccination with Dukoral in different age groups of Bangladeshi participants.

Author

Dash, Pinki, Hakim, Al, Akter, Aklima, Al Banna, Hasan, Kaisar, M. Hasanul, Aktar, Amena, Jahan, Sultana Rownok, Ferdous, Jannatul, Basher, Salima Raiyan, Kamruzzaman, Mohammad, Chowdhury, Fahima, Akter, Afroza, Tauheed, Imam, Weil, Ana A., Charles, Richelle C., Calderwood, Stephen B., Ryan, Edward T., LaRocque, Regina C., Harris, Jason B., and Bhuiyan, Taufiqur Rahman

Published
2024
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12. Comparison of O-specific polysaccharide responses in patients following infection with Vibrio cholerae O139 versus vaccination with a bivalent (O1/O139) oral killed cholera vaccine in Bangladesh

Author

Kaisar, M. Hasanul, primary, Kelly, Meagan, additional, Kamruzzaman, Mohammad, additional, Bhuiyan, Taufiqur R., additional, Chowdhury, Fahima, additional, Khan, Ashraful Islam, additional, LaRocque, Regina C., additional, Calderwood, Stephen B., additional, Harris, Jason B., additional, Charles, Richelle C., additional, Čížová, Alžbeta, additional, Mečárová, Jana, additional, Korcová, Jana, additional, Bystrický, Slavomír, additional, Kováč, Pavol, additional, Xu, Peng, additional, Qadri, Firdausi, additional, and Ryan, Edward T., additional

Published
2023
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13. Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection

Author

Midani, Firas S., Weil, Ana A., Chowdhury, Fahima, Begum, Yasmin A., Khan, Ashraful I., Debela, Meti D., Durand, Heather K., Reese, Aspen T., Nimmagadda, Sai N., Silverman, Justin D., Ellis, Crystal N., Ryan, Edward T., Calderwood, Stephen B., Harris, Jason B., Qadri, Firdausi, David, Lawrence A., and LaRocque, Regina C.

Published
2018

15. In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh.

Author

Sheikh, Alaullah, Charles, Richelle C, Sharmeen, Nusrat, Rollins, Sean M, Harris, Jason B, Bhuiyan, Md Saruar, Arifuzzaman, Mohammad, Khanam, Farhana, Bukka, Archana, Kalsy, Anuj, Porwollik, Steffen, Leung, Daniel T, Brooks, W Abdullah, LaRocque, Regina C, Hohmann, Elizabeth L, Cravioto, Alejandro, Logvinenko, Tanya, Calderwood, Stephen B, McClelland, Michael, Graham, James E, Qadri, Firdausi, and Ryan, Edward T

Subjects
Humans, Salmonella typhi, Bacteremia, Typhoid Fever, Bacterial Proteins, RNA, Bacterial, RNA, Messenger, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Adolescent, Adult, Middle Aged, Child, Child, Preschool, Infant, Bangladesh, Real-Time Polymerase Chain Reaction, RNA, Bacterial, Messenger, Preschool, Tropical Medicine, Biological Sciences, Medical and Health Sciences
Abstract

BackgroundSalmonella enterica serotype Typhi is the cause of typhoid fever. It is a human-restricted pathogen, and few data exist on S. Typhi gene expression in humans.Methodology/principal findingsWe applied an RNA capture and amplification technique, Selective Capture of Transcribed Sequences (SCOTS), and microarray hybridization to identify S. Typhi transcripts expressed in the blood of five humans infected with S. Typhi in Bangladesh. In total, we detected the expression of mRNAs for 2,046 S. Typhi genes (44% of the S. Typhi genome) in human blood; expression of 912 genes was detected in all 5 patients, and expression of 1,100 genes was detected in 4 or more patients. Identified transcripts were associated with the virulence-associated PhoP regulon, Salmonella pathogenicity islands, the use of alternative carbon and energy sources, synthesis and transport of iron, thiamine, and biotin, and resistance to antimicrobial peptides and oxidative stress. The most highly represented group were genes currently annotated as encoding proteins designated as hypothetical, unknown, or unclassified. Of the 2,046 detected transcripts, 1,320 (29% of the S. Typhi genome) had significantly different levels of detection in human blood compared to in vitro cultures; detection of 141 transcripts was significantly different in all 5 patients, and detection of 331 transcripts varied in at least 4 patients. These mRNAs encode proteins of unknown function, those involved in energy metabolism, transport and binding, cell envelope, cellular processes, and pathogenesis. We confirmed increased expression of a subset of identified mRNAs by quantitative-PCR.Conclusions/significanceWe report the first characterization of bacterial transcriptional profiles in the blood of patients with typhoid fever. S. Typhi is an important global pathogen whose restricted host range has greatly inhibited laboratory studies. Our results suggest that S. Typhi uses a largely uncharacterized genetic repertoire to survive within cells and utilize alternate energy sources during infection.

Published
2011

16. Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh.

Author

Sheikh, Alaullah, Charles, Richelle C, Rollins, Sean M, Harris, Jason B, Bhuiyan, Md Saruar, Khanam, Farhana, Bukka, Archana, Kalsy, Anuj, Porwollik, Steffen, Brooks, W Abdullah, LaRocque, Regina C, Hohmann, Elizabeth L, Cravioto, Alejandro, Logvinenko, Tanya, Calderwood, Stephen B, McClelland, Michael, Graham, James E, Qadri, Firdausi, and Ryan, Edward T

Subjects
Blood, Humans, Salmonella paratyphi A, Bacteremia, Paratyphoid Fever, DNA, Complementary, RNA, Bacterial, RNA, Messenger, Microarray Analysis, Gene Expression Profiling, Reverse Transcriptase Polymerase Chain Reaction, Adolescent, Adult, Middle Aged, Child, Child, Preschool, Bangladesh, Young Adult, DNA, Complementary, RNA, Bacterial, Messenger, Preschool, Tropical Medicine, Biological Sciences, Medical and Health Sciences
Abstract

BackgroundSalmonella enterica serotype Paratyphi A is a human-restricted cause of paratyphoid fever, accounting for up to a fifth of all cases of enteric fever in Asia.Methodology/principal findingsIn this work, we applied an RNA analysis method, Selective Capture of Transcribed Sequences (SCOTS), and cDNA hybridization-microarray technology to identify S. Paratyphi A transcripts expressed by bacteria in the blood of three patients in Bangladesh. In total, we detected 1,798 S. Paratyphi A mRNAs expressed in the blood of infected humans (43.9% of the ORFeome). Of these, we identified 868 in at least two patients, and 315 in all three patients. S. Paratyphi A transcripts identified in at least two patients encode proteins involved in energy metabolism, nutrient and iron acquisition, vitamin biosynthesis, stress responses, oxidative stress resistance, and pathogenesis. A number of detected transcripts are expressed from PhoP and SlyA-regulated genes associated with intra-macrophage survival, genes contained within Salmonella Pathogenicity Islands (SPIs) 1-4, 6, 10, 13, and 16, as well as RpoS-regulated genes. The largest category of identified transcripts is that of encoding proteins with unknown function. When comparing levels of bacterial mRNA using in vivo samples collected from infected patients to samples from in vitro grown organisms, we found significant differences for 347, 391, and 456 S. Paratyphi A transcripts in each of three individual patients (approximately 9.7% of the ORFeome). Of these, expression of 194 transcripts (4.7% of ORFs) was concordant in two or more patients, and 41 in all patients. Genes encoding these transcripts are contained within SPI-1, 3, 6 and 10, PhoP-regulated genes, involved in energy metabolism, nutrient acquisition, drug resistance, or uncharacterized genes. Using quantitative RT-PCR, we confirmed increased gene expression in vivo for a subset of these genes.Conclusion/significanceTo our knowledge, we describe the first microarray-based transcriptional analysis of a pathogen in the blood of naturally infected humans.

Published
2010

24. Long-term sialidase-specific immune responses after natural infection with cholera: Findings from a longitudinal cohort study in Bangladesh

Author

Chowdhury, Fahima, primary, Akter, Afroza, additional, Bhuiyan, Taufiqur Rahman, additional, Biswas, Rajib, additional, Firoj, Md. Golam, additional, Tauheed, Imam, additional, Harris, Jason B., additional, Larocque, Regina C., additional, Ross, Allen G., additional, McMillan, Nigel A. J., additional, Charles, Richelle C., additional, Ryan, Edward T., additional, Calderwood, Stephen B., additional, and Qadri, Firdausi, additional

Published
2022
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25. Identifying Recent Cholera Infections Using a Multiplex Bead Serological Assay

Author

Jones, Forrest K., primary, Bhuiyan, Taufiqur R., additional, Muise, Rachel E., additional, Khan, Ashraful I., additional, Slater, Damien M., additional, Hutt Vater, Kian Robert, additional, Chowdhury, Fahima, additional, Kelly, Meagan, additional, Xu, Peng, additional, Kováč, Pavol, additional, Biswas, Rajib, additional, Kamruzzaman, Mohammad, additional, Ryan, Edward T., additional, Calderwood, Stephen B., additional, LaRocque, Regina C., additional, Lessler, Justin, additional, Charles, Richelle C., additional, Leung, Daniel T., additional, Qadri, Firdausi, additional, Harris, Jason B., additional, and Azman, Andrew S., additional

Published
2022
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26. Longevity of memory B cells and antibodies, as well as the polarization of effector memory helper T cells, are associated with disease severity in patients with COVID-19 in Bangladesh

Author

Akhtar, Marjahan, primary, Basher, Salima Raiyan, additional, Nizam, Nuder Nower, additional, Kamruzzaman, Mohammad, additional, Khaton, Fatema, additional, Banna, Hasan Al, additional, Kaisar, M Hasanul, additional, Karmakar, Polash Chandra, additional, Hakim, Al, additional, Akter, Afroza, additional, Ahmed, Tasnuva, additional, Tauheed, Imam, additional, Islam, Shaumik, additional, Ahmmed, Faisal, additional, Mahamud, Shakil, additional, Hasnat, Mohammad Abul, additional, Sumon, Mostafa Aziz, additional, Rashed, Asif, additional, Ghosh, Shuvro, additional, Calderwood, Stephen B., additional, Harris, Jason B., additional, Charles, Richelle C., additional, LaRocque, Regina C., additional, Ryan, Edward T., additional, Banu, Sayera, additional, Shirin, Tahmina, additional, Chowdhury, Fahima, additional, Bhuiyan, Taufiqur Rahman, additional, and Qadri, Firdausi, additional

Published
2022
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29. Identifying recent cholera infections using a multiplex bead serological assay

Author

Jones, Forrest Kirby, primary, Bhuiyan, Md. Taufiqur Rahman, additional, Mills, Rachel, additional, Khan, Ashraful Islam K, additional, Slater, Damien, additional, Vater, Kian Robert Hutt, additional, Chowdhury, Fahima, additional, Kelly, Meagan, additional, Xu, Peng, additional, Kovac, Pavol, additional, Biswas, Rajib, additional, Kamruzzaman, Mohammad, additional, Ryan, Edward T, additional, Calderwood, Stephen B, additional, LaRocque, Regina C, additional, Lessler, Justin, additional, Charles, Richelle, additional, Leung, Daniel, additional, Qadri, Firdausi, additional, Harris, Jason B, additional, and Azman, Andrew S, additional

Published
2022
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30. A systems serology analysis of correlates of protection against cholera

Author

Wiens, Kirsten E, primary, Iyer, Anita S, additional, Bhuiyan, Taufiqur R, additional, Lu, Lenette L, additional, Cizmeci, Deniz, additional, Gorman, Matthew J, additional, Yuan, Dansu, additional, Becker, Rachel L, additional, Ryan, Edward T, additional, Calderwood, Stephen B, additional, LaRocque, Regina C, additional, Chowdhury, Fahima, additional, Khan, Ashraful I, additional, Levine, Myron M, additional, Chen, Wilbur H, additional, Charles, Richelle C, additional, Azman, Andrew S, additional, Qadri, Firdausi, additional, Alter, Galit, additional, and Harris, Jason B, additional

Published
2022
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31. Mucosal-Associated Invariant T (MAIT) cells are highly activated in duodenal tissue of humans with Vibrio cholerae O1 infection: A preliminary report

Author

Bhuiyan, Taufiqur R., primary, Rahman, M. Arifur, additional, Trivedi, Shubhanshi, additional, Afroz, Taliman, additional, Al Banna, Hasan, additional, Hoq, Mohammad Rubel, additional, Pop, Ioana, additional, Jensen, Owen, additional, Rashu, Rasheduzzaman, additional, Uddin, Muhammad Ikhtear, additional, Hossain, Motaher, additional, Khan, Ashraful I., additional, Chowdhury, Fahima, additional, Harris, Jason B., additional, Calderwood, Stephen B., additional, Ryan, Edward T., additional, Qadri, Firdausi, additional, and Leung, Daniel T., additional

Published
2022
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33. LPLUNC1 Modulates Innate Immune Responses to Vibrio cholerae

Author

Shin, Ok S., Uddin, Taher, Citorik, Robert, Wang, Jennifer P., Pelle, Patricia Della, Kradin, Richard L., Bingle, Colin D., Bingle, Lynne, Camilli, Andrew, Bhuiyan, Taufiqur R., Shirin, Tahmina, Ryan, Edward T., Calderwood, Stephen B., Finberg, Robert W., Qadri, Firdausi, LaRocque, Regina C., and Harris, Jason B.

Published
2011
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37. Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, Bangladesh

Author

Akter, Afroza, primary, Ahmed, Tasnuva, additional, Tauheed, Imam, additional, Akhtar, Marjahan, additional, Rahman, Sadia Isfat Ara, additional, Khaton, Fatema, additional, Ahmmed, Faisal, additional, Ferdous, Jannatul, additional, Afrad, Mokibul Hassan, additional, Kawser, Zannat, additional, Hossain, Mohabbat, additional, Khondaker, Rabeya, additional, Hasnat, Mohammad Abul, additional, Sumon, Mostafa Aziz, additional, Rashed, Asif, additional, Ghosh, Shuvro, additional, Calderwood, Stephen B., additional, Charles, Richelle C., additional, Ryan, Edward T., additional, Khatri, Purvesh, additional, Maecker, Holden Terry, additional, Obermoser, Gerlinde, additional, Pulendran, Bali, additional, Clemens, John D., additional, Banu, Sayera, additional, Shirin, Tahmina, additional, LaRocque, Regina C., additional, Harris, Jason B., additional, Bhuiyan, Taufiqur Rahman, additional, Chowdhury, Fahima, additional, and Qadri, Firdausi, additional

Published
2022
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38. Scalable production and immunogenicity of a cholera conjugate vaccine

Author

Jeon, Suhi, primary, Kelly, Meagan, additional, Yun, Jeesun, additional, Lee, Byungman, additional, Park, Minchul, additional, Whang, Yoonhee, additional, Lee, Chankyu, additional, Halvorsen, Yuan-Di, additional, Verma, Smriti, additional, Charles, Richelle C., additional, Harris, Jason B., additional, Calderwood, Stephen B., additional, Leung, Daniel T., additional, Bhuiyan, Taufiqur R., additional, Qadri, Firdausi, additional, Kamruzzaman, Mohammad, additional, Cho, Somyoung, additional, Vann, Willie F., additional, Xu, Peng, additional, Kováč, Pavol, additional, Ganapathy, Ravi, additional, Lynch, Julia, additional, and Ryan, Edward T., additional

Published
2021
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40. Contributors

Author

Aagaard, Kjersti, primary, Abrahamian, Fredrick M., additional, Allos, Ban Mishu, additional, Andes, David R., additional, Aoki, Fred Y., additional, Apicella, Michael A., additional, Ard, Kevin L., additional, Arias, Cesar A., additional, Aronoff, David M., additional, Augenbraun, Michael H., additional, Averhoff, Francisco, additional, Azar, Dimitri T., additional, Baddour, Larry M., additional, Baden, Lindsey R., additional, Baker, Carol J., additional, Ballard, Ronald C., additional, Barber, Gerard R., additional, Barnes, Scott D., additional, Barouch, Dan H., additional, Barrett, Alan D., additional, Barshak, Miriam Baron, additional, Basavaraju, Sridhar V., additional, Batteiger, Byron E., additional, Baum, Stephen G., additional, Bayer, Arnold S., additional, Beckham, J. David, additional, Beekmann, Susan E., additional, Bell, Beth P., additional, Bennett, John E., additional, Bente, Dennis A., additional, Berbari, Elie F., additional, Berman, Jonathan, additional, Bertino, Joseph S., additional, Bhimraj, Adarsh, additional, Birdsall, Holly H., additional, Bisno, Alan L., additional, Blackburn, Brian G., additional, Blanton, Lucas S., additional, Blaser, Martin J., additional, Bleck, Thomas P., additional, Blijlevens, Nicole M.A., additional, Bobak, David A., additional, Bonnez, William, additional, Boothroyd, John C., additional, Borio, Luciana L., additional, Bosque, Patrick J., additional, Bower, John, additional, Bradsher, Robert W., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Brown, Patricia D., additional, Brown-Elliott, Barbara A., additional, Bruhn, Roberta L., additional, Bryant, Amy E., additional, Burd, Eileen M., additional, Burns, Jane C., additional, Bush, Larry M., additional, Calderwood, Stephen B., additional, Cano, Luz Elena, additional, Carpenter, Charles C.J., additional, Caserta, Mary T., additional, Castagnola, Elio, additional, Chaisson, Richard E., additional, Chambers, Henry F., additional, Chapman, Stephen J., additional, Chappell, James D., additional, Chen, Lea Ann, additional, Chen, Sharon C-A, additional, Chow, Anthony W., additional, Clark, Rebecca A., additional, Cohen, Jeffrey I., additional, Cohen, Myron S., additional, Cohen-Poradosu, Ronit, additional, Cohn, Susan E., additional, Connors, Mark, additional, Corey, Lawrence, additional, Cottrell, Mackenzie L., additional, Cover, Timothy L., additional, Cox, Heather L., additional, Craig, William A., additional, Crossley, Kent B., additional, Crumpacker, Clyde S., additional, Curran, James W., additional, Currie, Bart J., additional, D'Agata, Erika, additional, Damon, Inger K., additional, Darouiche, Rabih O., additional, DeBiasi, Roberta L., additional, Deepe, George S., additional, del Rio, Carlos, additional, Delemos, Andrew S., additional, DeLeo, Frank R., additional, DeMuri, Gregory P., additional, Densen, Peter, additional, Dermody, Terence S., additional, Dewar, Robin, additional, Diaz, James H., additional, Dieffenbach, Carl W., additional, Dienstag, Jules L., additional, Doi, Yohei, additional, Dolin, Raphael, additional, Donnelly, J. Peter, additional, Donnenberg, Michael S., additional, Donowitz, Gerald R., additional, Dormitzer, Philip R., additional, Drake, James M., additional, Dumler, J. Stephen, additional, Dummer, J. Stephen, additional, DuPont, Herbert L., additional, Durack, David T., additional, Durand, Marlene L., additional, Edelstein, Paul H., additional, Edmond, Michael B., additional, Edwards, John E., additional, Edwards, Morven S., additional, Eliopoulos, George M., additional, Ellison, Richard T., additional, Endy, Timothy P., additional, Engleberg, N. Cary, additional, Erdem, Hakan, additional, Ernst, Joel D., additional, Ernst, Peter B., additional, Fairhurst, Rick M., additional, Fairley, Jessica K., additional, Falkow, Stanley, additional, Falsey, Ann R., additional, Fauci, Anthony S., additional, Fekete, Thomas, additional, Fey, Paul D., additional, Fine, Steven M., additional, Fitzgerald, Daniel W., additional, Flores, Anthony R., additional, Forster, Derek, additional, Fowler, Vance G., additional, Freedman, David O., additional, Friedlander, Arthur M., additional, Galgiani, John N., additional, Gallin, John I., additional, Gallo, Robert C., additional, Gandhi, Tejal N., additional, Garrett, Wendy S., additional, Gaydos, Charlotte A., additional, Geisbert, Thomas W., additional, Gelfand, Jeffrey A., additional, Gelone, Steven P., additional, Gerding, Dale N., additional, Gershon, Anne A., additional, Gilsdorf, Janet R., additional, Goldstein, Ellie J.C., additional, Gordin, Fred M., additional, Graman, Paul S., additional, Grayson, M. Lindsay, additional, Greene, Jeffrey Bruce, additional, Griffin, Patricia M., additional, Griffith, David E., additional, Guerrant, Richard L., additional, Gul, H. Cem, additional, Haake, David A., additional, Haas, David W., additional, Haines, Charles, additional, Hall, Caroline Breese, additional, Hallak, Joelle, additional, Halperin, Scott A., additional, Hammerschlag, Margaret R., additional, Haque, Rashidul, additional, Harris, Jason B., additional, Hawkins, Claudia, additional, Hay, Roderick J., additional, Hedberg, Craig W., additional, Henderson, David K., additional, Henderson, Donald A., additional, High, Kevin P., additional, Hill, Adrian V.S., additional, Hill, David R., additional, Hinman, Alan R., additional, Hirsch, Martin S., additional, Hodowanec, Aimee, additional, Hohl, Tobias M., additional, Holland, Steven M., additional, Holzman, Robert S., additional, Hook, Edward W., additional, Hooper, David C., additional, Hooton, Thomas M., additional, Horowitz, Harold W., additional, Horsburgh, C. Robert, additional, Horton, James M., additional, Hospenthal, Duane R., additional, Hsueh, Kevin, additional, Hughes, James M., additional, Hynes, Noreen A., additional, Iovine, Nicole M., additional, Iredell, Jonathan R., additional, Ison, Michael G., additional, Janda, J. Michael, additional, Janoff, Edward N., additional, Johannsen, Eric C., additional, Kashuba, Angela D.M., additional, Kasper, Dennis L., additional, Kaye, Donald, additional, Kaye, Keith S., additional, Kaye, Kenneth M., additional, Kazura, James W., additional, Keystone, Jay S., additional, Khabbaz, Rima, additional, Khan, David A., additional, Khudyakov, Yury, additional, Kim, Rose, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klein, Jerome O., additional, Klompas, Michael, additional, Knoll, Bettina M., additional, Knowlton, Kirk U., additional, Koehler, Jane E., additional, Kohlhoff, Stephan A., additional, Könönen, Eija, additional, Kontoyiannis, Dimitrios P., additional, Koralnik, Igor J., additional, Korpe, Poonum S., additional, Koshy, Anita A., additional, Kovacs, Joseph A., additional, Kozarsky, Phyllis, additional, Krieger, John, additional, Kroger, Andrew T., additional, Kuehnert, Matthew J., additional, Kumar, Nalin M., additional, Kuruvilla, Merin Elizabeth, additional, LaRocque, Regina C., additional, Leggett, James E., additional, Legido-Quigley, Helena, additional, Levett, Paul N., additional, Levine, Donald P., additional, Levison, Matthew E., additional, Levitt, Alexandra, additional, Lewis, Russell E., additional, Liles, W. Conrad, additional, Lima, Aldo A.M., additional, Limaye, Ajit P., additional, Lipkin, W. Ian, additional, Litman, Nathan, additional, Lorber, Bennett, additional, Luna, Ruth Ann, additional, MacDougall, Conan, additional, Roy, Rob, additional, Mackowiak, Philip A., additional, Madoff, Lawrence C., additional, Magill, Alan J., additional, Maguire, James H., additional, Maldarelli, Frank, additional, Markoff, Lewis, additional, Marrazzo, Jeanne M., additional, Marrie, Thomas J., additional, Marth, Thomas, additional, Martin, David H., additional, Martin, Gregory J., additional, Marty, Francisco M., additional, Maslow, Melanie Jane, additional, Masur, Henry, additional, Mawle, Alison, additional, Mayer, Kenneth H., additional, McBride, John T., additional, McCarthy, James S., additional, McCormack, William M., additional, McGowan, Catherine C., additional, McIntosh, Kenneth, additional, Mead, Paul S., additional, Mikulska, Malgorzata, additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mitchell, David H., additional, Modlin, John F., additional, Mody, Rajal K., additional, Moellering, Robert C., additional, Moffa, Matthew, additional, Moir, Susan, additional, Montoya, José G., additional, Moore, Thomas A., additional, Moreillon, Philippe, additional, Morris, J. Glenn, additional, Morse, Caryn Gee, additional, Moseley, Robin, additional, Munford, Robert S., additional, Murphy, Edward L., additional, Murphy, Timothy F., additional, Murray, Barbara E., additional, Murray, Clinton K., additional, Murray, Patrick R., additional, Musher, Daniel M., additional, Nagel, Jerod L., additional, Nannini, Esteban C., additional, Narezkina, Anna, additional, Nash, Theodore E., additional, Nauseef, William M., additional, Nayak, Jennifer L., additional, Neill, Marguerite A., additional, O'Donnell, Judith A., additional, Ohl, Christopher A., additional, Okhuysen, Pablo C., additional, Onderdonk, Andrew B., additional, Opal, Steven M., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Osterholm, Michael T., additional, Ostroff, Stephen M., additional, Oxman, Michael N., additional, Paessler, Slobodan, additional, Page, Andrea V., additional, Pai, Manjunath P., additional, Palmore, Tara N., additional, Palraj, Raj, additional, Pappas, Peter G., additional, Pasternack, Mark S., additional, Patterson, Thomas F., additional, Pavan-Langston, Deborah, additional, Pegues, David A., additional, Penn, Robert L., additional, Perfect, John R., additional, Perlman, Stanley, additional, Petersen, Brett W., additional, Peterson, Phillip K., additional, Petri, William A., additional, Petti, Cathy A., additional, Philips, Jennifer A., additional, Philley, Julie V., additional, Phillips, Michael, additional, Pickering, Larry K., additional, Piot, Peter, additional, Pogue, Jason M., additional, Pop-Vicas, Aurora, additional, Portal-Celhay, Cynthia, additional, Powers, John H., additional, Price, Richard N., additional, Que, Yok-Ai, additional, Radolf, Justin D., additional, Ram, Sanjay, additional, Raoult, Didier, additional, Ravdin, Jonathan I., additional, Ray, Stuart C., additional, Reboli, Annette C., additional, Reitz, Marvin S., additional, Relman, David A., additional, Renault, Cybèle A., additional, Restrepo, Angela, additional, Rex, John H., additional, Rhee, Elizabeth G., additional, Roberts, Norbert J., additional, Romero, José R., additional, Rothman, Alan L., additional, Roy, Craig R., additional, Ruoff, Kathryn L., additional, Rupp, Mark E., additional, Rupprecht, Charles E., additional, Russo, Thomas A., additional, Rutala, William A., additional, Ryan, Edward T., additional, Safdar, Amar, additional, Sajadi, Mohammad M., additional, Salazar, Juan C., additional, Sarria, Juan Carlos, additional, Savoia, Maria C., additional, Sax, Paul E., additional, Scheld, W. Michael, additional, Schiffer, Joshua T., additional, Schlossberg, David, additional, Schneider, Thomas, additional, Schuchat, Anne, additional, Schwebke, Jane R., additional, Sears, Cynthia L., additional, Segal, Leopoldo N., additional, Sendi, Parham, additional, Sepkowitz, Kent A., additional, Septimus, Edward J., additional, Seregin, Alexey, additional, Shulman, Stanford T., additional, Siberry, George K., additional, Siddiqi, Omar K., additional, Sifri, Costi D., additional, Simberkoff, Michael S., additional, Simonetti, Francesco R., additional, Singh, Kamaljit, additional, Singh, Nina, additional, Singh, Upinder, additional, Sinner, Scott W., additional, Sivapalasingam, Sumathi, additional, Slater, Leonard N., additional, Smulian, A. George, additional, Sobel, Jack D., additional, Sohail, M. Rizwan, additional, Soper, David E., additional, Sorrell, Tania C., additional, Steckelberg, James M., additional, Steere, Allen C., additional, Steigbigel, Neal H., additional, Steinberg, James P., additional, Stephens, David S., additional, Sterling, Timothy R., additional, Stevens, David A., additional, Stevens, Dennis L., additional, Strahilevitz, Jacob, additional, Stratton, Charles W., additional, Suffredini, Anthony F., additional, Suh, Kathryn N., additional, Sulkowski, Mark S., additional, Swartz, Morton N., additional, Talbot, Thomas R., additional, Tan, C. Sabrina, additional, Tan, Ming, additional, Thio, Chloe Lynne, additional, Thomas, David L., additional, Thomas, Lora D., additional, Thomas, Stephen J., additional, Thorner, Anna R., additional, María Tobón, Angela, additional, Tramont, Edmund C., additional, Treanor, John J., additional, Trubiano, Jason, additional, Tsibris, Athe M.N., additional, Tunkel, Allan R., additional, Turner, Ronald B., additional, Tyler, Kenneth L., additional, Uluer, Ahmet, additional, van de Beek, Diederik, additional, van der Velden, Walter J.F.M., additional, Vannier, Edouard G., additional, Van, Trevor C., additional, Versalovic, James, additional, Viscoli, Claudio, additional, Wald, Ellen R., additional, Waldor, Matthew K., additional, Walker, David H., additional, Wallace, Richard J., additional, Walsh, Edward E., additional, Walsh, Stephen R., additional, Walzer, Peter D., additional, Wanke, Christine A., additional, Warren, Cirle A., additional, Washburn, Ronald G., additional, Waters, Valerie, additional, Weber, David J., additional, Weiden, Michael D., additional, Weinberg, Geoffrey A., additional, Weisdorf, Daniel J., additional, Weiss, Louis M., additional, Welch, David F., additional, Wellems, Thomas E., additional, Wenzel, Richard P., additional, Wharton, Melinda, additional, White, A. Clinton, additional, Whitley, Richard J., additional, Wilson, Walter R., additional, Wortmann, Glenn W., additional, Wright, William F., additional, Young, Jo-Anne H., additional, Young, Vincent B., additional, Yun, Nadezhda, additional, Zimmerli, Werner, additional, Zinner, Stephen H., additional, and Zurlo, John J., additional

Published
2015
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43. A Combination of Metagenomic and Cultivation Approaches Reveals Hypermutator Phenotypes within Vibrio cholerae-Infected Patients

Author

Levade, Inès, primary, Khan, Ashraful I., additional, Chowdhury, Fahima, additional, Calderwood, Stephen B., additional, Ryan, Edward T., additional, Harris, Jason B., additional, LaRocque, Regina C., additional, Bhuiyan, Taufiqur R., additional, Qadri, Firdausi, additional, Weil, Ana A., additional, and Shapiro, B. Jesse, additional

Published
2021
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44. Defining Polysaccharide-Specific Antibody Targets against Vibrio cholerae O139 in Humans following O139 Cholera and following Vaccination with a Commercial Bivalent Oral Cholera Vaccine, and Evaluation of Conjugate Vaccines Targeting O139

Author

Kamruzzaman, Mohammad, primary, Kelly, Meagan, additional, Charles, Richelle C., additional, Harris, Jason B., additional, Calderwood, Stephen B., additional, Akter, Aklima, additional, Biswas, Rajib, additional, Kaisar, M. Hasanul, additional, Bhuiyan, Taufiqur R., additional, Ivers, Louise C., additional, Ternier, Ralph, additional, Jerome, Jean-Gregory, additional, Pfister, Hélene B., additional, Lu, Xiaowei, additional, Soliman, Sameh E., additional, Ruttens, Bart, additional, Saksena, Rina, additional, Mečárová, Jana, additional, Čížová, Alžbeta, additional, Qadri, Firdausi, additional, Bystrický, Slavomír, additional, Kováč, Pavol, additional, Xu, Peng, additional, and Ryan, Edward T., additional

Published
2021
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47. COVID-19 Diagnostic Clinical Decision Support: a Pre-Post Implementation Study of CORAL (COvid Risk cALculator)

Author

Dugdale, Caitlin M, Rubins, David M, Lee, Hang, McCluskey, Suzanne M, Ryan, Edward T, Kotton, Camille N, Hurtado, Rocio M, Ciaranello, Andrea L, Barshak, Miriam B, McEvoy, Dustin S, Nelson, Sandra B, Basgoz, Nesli, Lazarus, Jacob E, Ivers, Louise C, Reedy, Jennifer L, Hysell, Kristen M, Lemieux, Jacob E, Heller, Howard M, Dutta, Sayon, Albin, John S, Brown, Tyler S, Miller, Amy L, Calderwood, Stephen B, Walensky, Rochelle P, Zachary, Kimon C, Hooper, David C, Hyle, Emily P, and Shenoy, Erica S

Subjects
COVID-19 diagnosis, AcademicSubjects/MED00290, clinical decision support system, SARS-CoV-2, Major Article, Odds Ratio, Animals, COVID-19, Humans, electronic health record, Anthozoa, diagnostic algorithm, Nucleic Acid Amplification Techniques
Abstract

Isolation of hospitalized persons under investigation (PUIs) for coronavirus disease 2019 (COVID-19) reduces nosocomial transmission risk. Efficient evaluation of PUIs is needed to preserve scarce healthcare resources. We describe the development, implementation, and outcomes of an inpatient diagnostic algorithm and clinical decision support system (CDSS) to evaluate PUIs.We conducted a pre-post study of CORAL (COvid Risk cALculator), a CDSS that guides frontline clinicians through a risk-stratified COVID-19 diagnostic workup, removes transmission-based precautions when workup is complete and negative, and triages complex cases to infectious diseases (ID) physician review. Before CORAL, ID physicians reviewed all PUI records to guide workup and precautions. After CORAL, frontline clinicians evaluated PUIs directly using CORAL. We compared pre- and post-CORAL frequency of repeated severe acute respiratory syndrome coronavirus 2 nucleic acid amplification tests (NAATs), time from NAAT result to PUI status discontinuation, total duration of PUI status, and ID physician work hours, using linear and logistic regression, adjusted for COVID-19 incidence.Fewer PUIs underwent repeated testing after an initial negative NAAT after CORAL than before CORAL (54% vs 67%, respectively; adjusted odd ratio, 0.53 [95% confidence interval, .44-.63]; P .01). CORAL significantly reduced average time to PUI status discontinuation (adjusted difference [standard error], -7.4 [0.8] hours per patient), total duration of PUI status (-19.5 [1.9] hours per patient), and average ID physician work-hours (-57.4 [2.0] hours per day) (all P .01). No patients had a positive NAAT result within 7 days after discontinuation of precautions via CORAL.CORAL is an efficient and effective CDSS to guide frontline clinicians through the diagnostic evaluation of PUIs and safe discontinuation of precautions.

Published
2021

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