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14. I farmaci del metabolismo

Author

ROSSI, Francesco, Calderaro V, Mangrella M., Rossi, Francesco, Calderaro, V, and Mangrella, M.

Published
1997

19. Antiflammins suppress the A23187- and arachidonic acid-dependent chloride secretion in rabbit distal colonic mucosa

Author

Calderaro V, Parrillo C, Alfonso Giovane, Greco R, Mg, Matera, Berrino L, Rossi F, Calderaro, V, Parrillo, C, Giovane, Alfonso, Greco, R, Matera, Maria Gabriella, Berrino, Liberato, and Rossi, Francesco

Subjects
Arachidonic Acid, Annexins, Molecular Sequence Data, Anti-Inflammatory Agents, Biological Transport, Dinoprostone, Phospholipases A, Phospholipases A2, Chlorides, Cyclic AMP, Animals, Cyclooxygenase Inhibitors, Amino Acid Sequence, Rabbits, Intestinal Mucosa, Peptides, Calcimycin
Abstract

Antiflammins are synthetic peptides with sequence homology to proteins inhibitory for phospholipase A2. The effects of antiflammins on chloride secretion induced by the calcium ionophore A23187, arachidonic acid (AA) and prostaglandin E2 (PGE2) were investigated in distal rabbit colonic mucosa mounted in Ussing-type chambers. 100 nM AF-2 (antiflammin 2, peptide HDMNKVLDL) fully prevented the increase in Isc, net chloride secretion, tissue PGE2 and second messenger cAMP induced by 5 microM A23187. AF-1 (antiflammin 1, peptide MQMKKVLDS) also inhibited, although to a lesser extent, the A23187-mediated increase in Isc. AF-2 inhibition began at doses of 100 nM (delta Isc -0.20 +/- 0.08, microEq h-1 cm-2, mean +/- S.E.M., N = 3) and was maximal at doses comprised between 200 and 250 nM (delta Isc -0.51 +/- 0.12, microEq h-1 cm-2, mean +/- S.E.M., N = 3). AF-2 also inhibited the increase in Isc and chloride secretion induced by the incubation with 10 microM AA and bradykinin but it was ineffective when tissues were stimulated with 10 microM PGE2. 100 nM AF-2 brought about an inhibition of the increase in AA-mediated increases in PGs and cAMP comparable to that of 10 microM of the cyclooxygenase inhibitor indomethacin. In vitro assay of colonic cyclooxygenase activity showed that 100 nM AF-2 and AF-1 inhibited cyclooxygenase activity (73 and approximately 30%, respectively), but they did not modify the in vitro activity of porcine phospholipase A2.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1992

34. Calcium oxalate nephrolithiasis: defective oxalate transport

Author

Borsatti, A, Rombola, G., Surian, M., Calo, L., Fabbris, A., Vezzoli, G, Calderaro, V, Maschio, G. BORGHI L., Bazzato, G, Desanto, N, Williams, He, Marangella, M, Colussi, G, Caudarella, R, Kassirer, Jp, Tasca, A., Schena, Fp, D'Angelo, Angela, Moracchiello, P., and Vezzoli, G

Subjects
Parathyroidectomy, Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Oxalic acid, chemistry.chemical_compound, Kidney Calculi, Internal medicine, medicine, Humans, Calcium calculus, Kidney, Oxalate transport, Oxalates, Calcium Oxalate, Hyperparathyroidism, Oxalic Acid, Calcium oxalate nephrolithiasis, Biological Transport, Endocrinology, medicine.anatomical_structure, chemistry, Nephrology, Oxalates urine
Published
1991

46. Optimal Generation Rescheduling in Microgrids Under Uncertainty.

Author

Calderaro, V., Galdi, V., Graber, G., and Piccolo, A.

Subjects
ELECTRON tube grids, DISTRIBUTED power generation, STABLE equilibrium (Physics), FUZZY numbers, ELECTRIC power production, RENEWABLE energy sources, RADIAL distribution function
Abstract

Microgrids could increase reliability locally through the establishment of a specific improvement plan that integrates distributed power generation and other smart technologies. In this paper we propose a solution method for an optimal generation rescheduling problem in microgrids in order to determinate a stable equilibrium state following outages. The presented approach, focused on MV distribution systems, takes into account uncertainty modeled by Fuzzy Numbers due to both the load profiles and the power production from renewable energy sources. The method has been tested on 69-bus radial distribution systems considering two outage cases to demonstrate the performance and effectiveness of the proposed method. The obtained encouraging results are presented and discussed. [ABSTRACT FROM AUTHOR]

Published
2013

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