505 results on '"Calci A."'
Search Results
2. The Fenice project to evaluate and improve the quality of healthcare in high-dependency care units: results after the first year
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Porta, Giovanni, Signorini, Fabiola, Converso, Marcella, Cavalot, Giulia, Caramello, Valeria, Rossi, Carlotta, Aprà, Franco, Beltrame, Angela, Boccuzzi, Adriana, Boverio, Riccardo, Calci, Mario, Castaldo, Ersilia, Covella, Michele, Cuppini, Patrizia, Ghilardi, Giulia Irene, Mirante, Enrico, Noto, Paola, Pierpaoli, Lucia, Parpaglia, Paolo Pinna, Ricchiardi, Alberto, Zanetti, Michele, Zatelli, Daniela, Nattino, Giovanni, and Bertolini, Guido
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- 2024
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3. The natural partial order on modules
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Pakel, T., Calci, T. P., Halicioglu, S., Harmanci, A., and Ungor, B.
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- 2024
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4. The Natural partial order on modules
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Pakel, Tugba, Calci, Tugce Pekacar, Halicioglu, Sait, Harmanci, Abdullah, and Ungor, Burcu
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Mathematics - Rings and Algebras ,06A06, 06F25, 06F99, 16B99 - Abstract
The Mitsch order is already known as a natural partial order for semigroups and rings. The purpose of this paper is to further study of the Mitsch order on modules by investigating basic properties via endomorphism rings. And so this study also contribute to the results related to the orders on rings. As a module theoretic analog of the Mitsch order, we show that this order is a partial order on arbitrary modules. Among others, lattice properties of the Mitsch order and the relations between the Mitsch order and the other well-known orders, such as, the minus order, the Jones order, the direct sum order and the space pre-order on modules are studied. In particular, we prove that the minus order is the Mitsch order and we supply an example to show that the converse does not hold in general.
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- 2022
5. SARS-CoV-2 wastewater variant surveillance: pandemic response leveraging FDA’s GenomeTrakr network
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Ruth E. Timme, Jacquelina Woods, Jessica L. Jones, Kevin R. Calci, Rachel Rodriguez, Candace Barnes, Elizabeth Leard, Mark Craven, Haifeng Chen, Cameron Boerner, Christopher Grim, Amanda M. Windsor, Padmini Ramachandran, Tim Muruvanda, Hugh Rand, Bereket Tesfaldet, Jasmine Amirzadegan, Tunc Kayikcioglu, Tamara Walsky, Marc Allard, Maria Balkey, C. Hope Bias, Eric Brown, Kathryn Judy, Tina Pfefer, Sandra M. Tallent, Maria Hoffmann, and James Pettengill
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SARS-CoV-2 ,wastewater surveillance ,data structures ,FAIR data ,data standards ,pathogen genomic surveillance ,Microbiology ,QR1-502 - Abstract
ABSTRACT Wastewater surveillance has emerged as a crucial public health tool for population-level pathogen surveillance. Supported by funding from the American Rescue Plan Act of 2021, the FDA‘s genomic epidemiology program, GenomeTrakr, was leveraged to sequence SARS-CoV-2 from wastewater sites across the United States. This initiative required the evaluation, optimization, development, and publication of new methods and analytical tools spanning sample collection through variant analyses. Version-controlled protocols for each step of the process were developed and published on protocols.io. A custom data analysis tool and a publicly accessible dashboard were built to facilitate real-time visualization of the collected data, focusing on the relative abundance of SARS-CoV-2 variants and sub-lineages across different samples and sites throughout the project. From September 2021 through June 2023, a total of 3,389 wastewater samples were collected, with 2,517 undergoing sequencing and submission to NCBI under the umbrella BioProject, PRJNA757291. Sequence data were released with explicit quality control (QC) tags on all sequence records, communicating our confidence in the quality of data. Variant analysis revealed wide circulation of Delta in the fall of 2021 and captured the sweep of Omicron and subsequent diversification of this lineage through the end of the sampling period. This project successfully achieved two important goals for the FDA’s GenomeTrakr program: first, contributing timely genomic data for the SARS-CoV-2 pandemic response, and second, establishing both capacity and best practices for culture-independent, population-level environmental surveillance for other pathogens of interest to the FDA.IMPORTANCEThis paper serves two primary objectives. First, it summarizes the genomic and contextual data collected during a Covid-19 pandemic response project, which utilized the FDA’s laboratory network, traditionally employed for sequencing foodborne pathogens, for sequencing SARS-CoV-2 from wastewater samples. Second, it outlines best practices for gathering and organizing population-level next generation sequencing (NGS) data collected for culture-free, surveillance of pathogens sourced from environmental samples.
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- 2024
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6. A bilevel approach to multi-period natural gas pricing and investment in gas-consuming infrastructure
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Çalcı, Baturay, Leibowicz, Benjamin D., Bard, Jonathan F., and Jayadev, Gopika G.
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- 2024
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7. Properties of 4He and 6Li with improved chiral EFT interactions
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Maris P., Binder S., Calci A., Epelbaum E., Furnstahl R.J., Golak J., Hebeler K., Kamada H., Krebs H., Langhammer J., Liebig S., Meißner U.-G., Minossi D., Nogga A., Potter H., Roth R., Skibiński R., Topolnicki K., Vary J.P., and Witala H.
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Physics ,QC1-999 - Abstract
We present recent results for 4He and 6Li obtained with improved NN interactions derived from chiral effective field theory up to N4LO. The many-body calculations are performed order-by-order in the chiral expansion. At N3LO and N4LO additional renormalization using the Similarity Renormalization Group is adopted to improve numerical convergence of the many-body calculations. We discuss results for the ground state energies, as well as the magnetic moment and the low-lying spectrum of 6Li.
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- 2016
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8. Perturbation for group inverse in a Banach algebra
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Liu, Dayong, Calci, Tugce Pekacar, Kose, Handan, and Chen, Huanyin
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Mathematics - Rings and Algebras ,15A09, 47L10, 32A65 - Abstract
We present new additive results for the group inverse in a Banach algebra under certain perturbations. The upper bound of $\|(a+b)^{\#}-a^d\|$ is thereby given. These extend the main results in [X. Liu, Y. Qin and H. Wei, Perturbation bound of the group inverse and the generalized Schur complement in Banach algebra, Abstr. Appl. Anal., 2012, 22 pages. DOI:10.1155/2012/629178]., Comment: 17 pages
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- 2021
9. Neutrophil gelatinase-associated lipocalin (NGAL) and inflammatory markers in schizophrenia: A comparative analysis of drug-naive schizophrenia patients, remitted patients, and healthy controls
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Çiftci, Hatice, Aşut, Gonca, Kaya, Hasan, Çakmak, Işık Batuhan, Aydıner Yılmaz, Meltem, Çöpür, Ahmet, Çalcı, Esin, Fırat Oğuz, Esra, Turhan, Turan, and Göka, Erol
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- 2024
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10. A Generalization of Reflexive Rings
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Calci, M. B., Chen, H., and Halicioglu, S.
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Mathematics - Rings and Algebras - Abstract
In this paper, we introduce a class of rings which is a generalization of reflexive rings and $J$-reversible rings. Let $R$ be a ring with identity and $J(R)$ denote the Jacobson radical of $R$. A ring $R$ is called {\it $J$-reflexive} if for any $a$, $b \in R$, $aRb = 0$ implies $bRa \subseteq J(R)$. We give some characterizations of a $J$-reflexive ring. We prove that some results of reflexive rings can be extended to $J$-reflexive rings for this general setting. We conclude some relations between $J$-reflexive rings and some related rings. We investigate some extensions of a ring which satisfies the $J$-reflexive property and we show that the $J$-reflexive property is Morita invariant., Comment: appears in Mathematica Bohemica
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- 2019
11. Prime Structures in a Morita Context
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Calci, Mete Burak, Halicioglu, Sait, Harmanci, Abdullah, and Ungor, Burcu
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Mathematics - Rings and Algebras ,16D80, 16S50, 16S99 - Abstract
In this paper, we study on the primeness and semiprimeness of a Morita context related to the rings and modules. Necessary and sufficient conditions are investigated for an ideal of a Morita context to be a prime ideal and a semiprime ideal. In particular, we determine the conditions under which a Morita context is prime and semiprime.
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- 2018
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12. Multiple Indicators of Wastewater Contamination to Shellfish Farms Near a Tidal River
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Frith, Ashley, Henseler, Julian, Badri, Shahrzad, Calci, Kevin R., Stenson, Alexandra, and Carmichael, Ruth H.
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- 2022
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13. Few- and many-nucleon systems with semilocal coordinate-space regularized chiral nucleon-nucleon forces
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Binder, S., Calci, A., Epelbaum, E., Furnstahl, R. J., Golak, J., Hebeler, K., Hüther, T., Kamada, H., Krebs, H., Maris, P., Meißner, U. -G., Nogga, A., Roth, R., Skibiński, R., Topolnicki, K., Vary, J. P., Vobig, K., and Witała, H.
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Nuclear Theory - Abstract
We employ a variety of ab initio methods including Faddeev-Yakubovsky equations, No-Core Configuration Interaction Approach, Coupled-Cluster Theory and In-Medium Similarity Renormalization Group to perform a comprehensive analysis of the nucleon-deuteron elastic and breakup reactions and selected properties of light and medium-mass nuclei up to 48Ca using the recently constructed semilocal coordinate-space regularized chiral nucleon-nucleon potentials. We compare the results with those based on selected phenomenological and chiral EFT two-nucleon potentials, discuss the convergence pattern of the chiral expansion and estimate the achievable theoretical accuracy at various chiral orders using the novel approach to quantify truncation errors of the chiral expansion without relying on cutoff variation. We also address the robustness of this method and explore alternative ways to estimate the theoretical uncertainty from the truncation of the chiral expansion., Comment: 34 pages, 15 figures, 11 tables
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- 2018
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14. Structure of the exotic $^9$He nucleus from the no-core shell model with continuum
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Vorabbi, Matteo, Calci, Angelo, Navratil, Petr, Kruse, Michael K. G, Quaglioni, Sofia, and Hupin, Guillaume
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Nuclear Theory - Abstract
The exotic $^9$He nucleus, which presents one of the most extreme neutron-to-proton ratios, belongs to the $N=7$ isotonic chain famous for the phenomenon of ground-state parity inversion with decreasing number of protons. Consequently, it would be expected to have an unnatural (positive) parity ground state similar to $^{11}$Be and $^{10}$Li. Despite many experimental and theoretical investigations, its structure remains uncertain. Apart from the fact that it is unbound, other properties including the spin and parity of its ground state and the very existence of additional low-lying resonances are still a matter of debate. In this work we study the properties of $^9$He by analyzing the $n+^8$He continuum in the context of the ab initio no-core shell model with continuum (NCSMC) formalism with chiral interactions as the only input. The NCSMC is a state-of-the-art approach for the ab initio description of light nuclei. With its capability to predict properties of bound states, resonances, and scattering states in a unified framework, the method is particularly well suited for the study of unbound nuclei such as $^9$He. Our analysis produces an unbound $^9$He nucleus. Two resonant states are found at the energies of ${\sim}1$ and ${\sim}3.5$ MeV, respectively, above the $n+^8$He breakup threshold. The first state has a spin-parity assignment of $J^{\pi} = {1/2}^-$ and can be associated with the ground state of $^9$He, while the second, broader state has a spin-parity of ${3/2}^-$. No resonance is found in the ${1/2}^+$ channel, only a very weak attraction. We find that the $^9$He ground-state resonance has a negative parity and thus breaks the parity-inversion mechanism found in the $^{11}$Be and $^{10}$Li nuclei of the same $N=7$ isotonic chain.
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- 2017
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15. Microscopic optical potentials derived from ab initio translationally invariant nonlocal one-body densities
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Gennari, Michael, Vorabbi, Matteo, Calci, Angelo, and Navratil, Petr
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Nuclear Theory - Abstract
We derive a microscopic optical potential for intermediate energies using ab initio translationally invariant nonlocal one-body nuclear densities computed within the no-core shell model (NCSM) approach utilizing two- and three-nucleon chiral interactions as the only input. The optical potential is derived at first-order within the spectator expansion of the non-relativistic multiple scattering theory by adopting the impulse approximation and using the same chiral nucleon-nucleon interaction as that used to compute densities. The ground state local and nonlocal densities of 4,6,8He, 12C, and 16O are calculated and applied to optical potential construction. The differential cross sections and the analyzing powers for the elastic proton scattering off of these nuclei are then calculated for different values of the incident proton energy. The impact of nonlocality and the COM removal is discussed. The use of nonlocal densities has a substantial impact on the differential cross sections and improves agreement with experiment in comparison to results generated with the local densities especially for light nuclei.
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- 2017
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16. Effect of intermediate/high versus low dose heparin on the thromboembolic and hemorrhagic risk of unvaccinated COVID-19 patients in the emergency department
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Claudia Marchioni, Gaetano Esposito, Mario Calci, Bruno Bais, and GianLuca Colussi
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SARS-CoV-2 ,Coronavirus ,Survival analysis ,Mortality ,Anticoagulants ,Hemorrhage ,Special situations and conditions ,RC952-1245 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The optimal prophylactic dose of heparin in patients with coronavirus-associated disease 2019 (COVID-19) in the emergency department (ED) is debated. This study aimed to analyze different thromboprophylaxis approaches in unvaccinated COVID-19 patients admitted to ED without initial venous thromboembolism. Methods Retrospectively, the effect of intermediate/high versus low dose heparin treatment was evaluated from December 2020 to July 2021 in a tertiary Academic Hospital in northeast Italy. The primary outcome comprised arterial or venous thromboembolism or all-cause death within 30 days. Secondary outcomes comprised each single primary outcome component or major hemorrhagic event. Cox regression was used to determine predictors of the primary outcome and propensity score weights to balance the effect of heparin treatment on all outcomes. Results Data of 144 consecutive patients (age 70 ± 13, 33% females) were included in the study. High-dose prophylactic heparin was used in 69%, intermediate in 15%, and low in 17% of patients. The primary outcome occurred in 48 patients. Independent predictors of the primary outcome were COVID-19 severity (hazards ratio (HR) 1.96, 95% confidence interval (CI) 1.05–3.65, p = 0.035) and D-dimer levels (HR each log ng/dl 1.38, 95% CI 1.04–1.84, p = 0.026). Intermediate/high dose heparin did not affect the risk of the primary outcome compared with the low dose (weighted HR 1.39, 95% CI 0.75–2.56, p = 0.292). Intermediate/high heparin increased the risk of major hemorrhagic events (weighted HR 5.92, 95% CI 1.09–32, p = 0.039). Conclusions In unvaccinated COVID-19 patients admitted to ED, prophylaxis with heparin at the intermediate/high dose did not reduce primary outcome compared with the low dose but increased the risk of major hemorrhagic events.
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- 2022
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17. North American Natural Gas Markets Under LNG Demand Growth and Infrastructure Restrictions
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Calci, Baturay, Leibowicz, Benjamin D., and Bard, Jonathan F.
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Natural gas -- Market size -- Forecasts and trends -- Market research ,Liquefied natural gas industry -- Market size -- Industry forecasts -- Market research ,Marketing research ,Market trend/market analysis ,Business ,Economics ,Petroleum, energy and mining industries - Abstract
Strong liquefied natural gas (LNG) demand growth, especially in Asia, could increasingly motivate gas infrastructure development in North America. Nevertheless, opposition to new gas infrastructure is formidable in some of the U.S. states and Canadian provinces that are well positioned to supply LNG to the Asian market. In this paper, we investigate the combined effects of LNG demand growth and export infrastructure restrictions on North American natural gas markets through 2050. To do so, we build a mixed complementarity model with endogenous capacity investments. It is parameterized using publicly available data sources. Our results show that even if new export terminals cannot be constructed on the West Coast, LNG exports largely shift to other regions rather than suffer an overall decline. Increasing external demand for LNG puts upward pressure on regional prices in North America, and directs production and pipeline flows toward the regions that export LNG. Keywords: Natural gas, LNG, Energy markets, Market modeling, Mixed complementarity, North America, 1. INTRODUCTION North American natural gas markets have undergone sweeping transformations over the past two decades. The 2000s witnessed the shale gas revolution, where hydraulic fracturing and horizontal drilling led [...]
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- 2022
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18. Strategic interactions between liquefied natural gas and domestic gas markets: A bilevel model
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Jayadev, Gopika, Leibowicz, Benjamin D., Bard, Jonathan F., and Çalcı, Baturay
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- 2022
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19. Risk-averse stochastic bilevel programming: An application to natural gas markets
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Jayadev, Gopika, Leibowicz, Benjamin D., Bard, Jonathan F., and Çalci, Baturay
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- 2022
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20. Effect of intermediate/high versus low dose heparin on the thromboembolic and hemorrhagic risk of unvaccinated COVID-19 patients in the emergency department
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Marchioni, Claudia, Esposito, Gaetano, Calci, Mario, Bais, Bruno, and Colussi, GianLuca
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- 2022
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21. Comparative affinity immobilization of α-galactosidase on chitosan functionalized with Concanavalin A and its useability for the hydrolysis of raffinose
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Çalcı, Esin and Önal, Seçil
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- 2022
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22. The nuclear force imprints revealed on the elastic scattering of protons with $^{10}$C
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Kumar, A., Kanungo, R., Calci, A., Navratil, P., Sanetullaev, A., Alcorta, M., Bildstein, V., Christian, G., Davids, B., Dohet-Eraly, J., Fallis, J., Gallant, A. T., Hackman, G., Hadinia, B., Hupin, G., Ishimoto, S., Krücken, R., Laffoley, A. T., Lighthall, J., Miller, D., Quaglioni, S., Randhawa, J. S., Rand, E. T., Rojas, A., Roth, R., Shotter, A., Tanaka, J., Tanihata, I., and Unsworth, C.
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Nuclear Experiment ,Nuclear Theory - Abstract
How does nature hold together protons and neutrons to form the wide variety of complex nuclei in the universe? Describing many-nucleon systems from the fundamental theory of quantum chromodynamics has been the greatest challenge in answering this question. The chiral effective field theory description of the nuclear force now makes this possible but requires certain parameters that are not uniquely determined. Defining the nuclear force needs identification of observables sensitive to the different parametrizations. From a measurement of proton elastic scattering on $^{10}$C at TRIUMF and ab initio nuclear reaction calculations we show that the shape and magnitude of the measured differential cross section is strongly sensitive to the nuclear force prescription., Comment: 7 pages, 6 figures
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- 2017
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23. Incorporating learning-by-doing into mixed complementarity equilibrium models
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Çalcı, Baturay, Leibowicz, Benjamin D., Bard, Jonathan F., and Jayadev, Gopika G.
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- 2021
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24. Can Ab Initio Theory Explain the Phenomenon of Parity Inversion in ${}^{11}$Be?
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Calci, Angelo, Navrátil, Petr, Roth, Robert, Dohet-Eraly, Jérémy, Quaglioni, Sofia, and Hupin, Guillaume
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Nuclear Theory ,Nuclear Experiment - Abstract
The weakly bound exotic ${}^{11}$Be nucleus, famous for its ground-state parity inversion and distinct n+ ${}^{10}$Be halo structure, is investigated from first principles using chiral two- and three-nucleon forces. An explicit treatment of continuum effects is found to be indispensable. We study the sensitivity of the ${}^{11}$Be spectrum to the details of the three-nucleon force and demonstrate that only certain chiral interactions are capable of reproducing the parity inversion. With such interactions, the extremely large E1 transition between the bound states is reproduced. We compare our photodisintegration calculations to conflicting experimental data and predict a distinct dip around the $3/2^-_1$ resonance energy. Finally, we predict low-lying $3/2^+$ and $9/2^+$ resonances that are not or not sufficiently measured in experiments., Comment: 6 pages, 5 figures, plus Supplemental Material
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- 2016
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25. A nucleus-dependent valence-space approach to nuclear structure
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Stroberg, S. R., Calci, A., Hergert, H., Holt, J. D., Bogner, S. K., Roth, R., and Schwenk, A.
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Nuclear Theory ,Nuclear Experiment - Abstract
We present a nucleus-dependent valence-space approach for calculating ground and excited states of nuclei, which generalizes the shell-model in-medium similarity renormalization group to an ensemble reference with fractionally filled orbitals. Because the ensemble is used only as a reference, and not to represent physical states, no symmetry restoration is required. This allows us to capture 3N forces among valence nucleons with a valence-space Hamiltonian specifically targeted to each nucleus of interest. Predicted ground-state energies from carbon through nickel agree with results of other large-space ab initio methods, generally to the 1\% level. In addition, we show that this new approach is required in order to obtain convergence for nuclei in the upper $p$ and $sd$ shells. Finally, we address the $1^+$/$3^+$ ground-state inversion problem in $^{22}\text{Na}$ and $^{46}\text{V}$. This approach extends the reach of ab initio nuclear structure calculations to essentially all light- and medium-mass nuclei., Comment: 6 pages, 5 figures
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- 2016
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26. Sensitivities and correlations of nuclear structure observables emerging from chiral interactions
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Calci, Angelo and Roth, Robert
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Nuclear Theory - Abstract
Starting from a set of different two- and three-nucleon interactions from chiral effective field theory, we use the importance-truncated no-core shell model for ab initio calculations of excitation energies as well as electric quadrupole (E2) and magnetic dipole (M1) moments and transition strengths for selected p-shell nuclei. We explore the sensitivity of the excitation energies to the chiral interactions as a first step towards and systematic uncertainty propagation from chiral inputs to nuclear structure observables. The uncertainty band spanned by the different chiral interactions is typically in agreement with experimental excitation energies, but we also identify observables with notable discrepancies beyond the theoretical uncertainty that reveal insufficiencies in the chiral interactions. For electromagnetic observables we identify correlations among pairs of E2 or M1 observables based on the ab initio calculations for the different interactions. We find extremely robust correlations for E2 observables and illustrate how these correlations can be used to predict one observable based on an experimental datum for the second observable. In this way we circumvent convergence issues and arrive at far more accurate results than any direct ab initio calculation. A prime example for this approach is the quadrupole moment of the first 2^+ state in C-12, which is predicted with an drastically improved accuracy., Comment: 11 pages, 8 figures
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- 2016
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27. Unified ab initio approaches to nuclear structure and reactions
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Navratil, Petr, Quaglioni, Sofia, Hupin, Guillaume, Romero-Redondo, Carolina, and Calci, Angelo
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Nuclear Theory ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Experiment - Abstract
The description of nuclei starting from the constituent nucleons and the realistic interactions among them has been a long-standing goal in nuclear physics. In addition to the complex nature of the nuclear forces, with two-, three- and possibly higher many-nucleon components, one faces the quantum-mechanical many-nucleon problem governed by an interplay between bound and continuum states. In recent years, significant progress has been made in ab initio nuclear structure and reaction calculations based on input from QCD-employing Hamiltonians constructed within chiral effective field theory. After a brief overview of the field, we focus on ab initio many-body approaches - built upon the No-Core Shell Model - that are capable of simultaneously describing both bound and scattering nuclear states, and present results for resonances in light nuclei, reactions important for astrophysics and fusion research. In particular, we review recent calculations of resonances in the $^6$He halo nucleus, of five- and six-nucleon scattering, and an investigation of the role of chiral three-nucleon interactions in the structure of $^9$Be. Further, we discuss applications to the $^7$Be$(p,\gamma)^8$B radiative capture. Finally, we highlight our efforts to describe transfer reactions including the $^3$H$(d,n)^4$He fusion., Comment: Contribution to the Special Physica Scripta Edition - 40 year anniversary - Nobel Prize '75, 71 pages, 29 figures
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- 2016
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28. New Horizons in Ab Initio Nuclear Structure Theory
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Roth, Robert, Langhammer, Joachim, Binder, Sven, Calci, Angelo, Roth, Robert, Langhammer, Joachim, Binder, Sven, and Calci, Angelo
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Nuclear interactions derived within chiral effective field theory enable nuclear structure and reaction calculations solidly rooted in QCD. Using chiral two- and three-body interactions in ab initio studies of a variety of nuclear observables is, both, promising and challenging. Particularly the inclusion of chiral 3N interactions into exact and approximate many-body calculations is demanding and computationally expensive. We present recent key developments that facilitate ab initio calculations of ground and low-lying excited states of p- and sd-shell nuclei with full 3N interactions in the Importance-Truncated No-Core Shell Model using consistent Similarity Renormalization Group transformations of the NN+3N Hamiltonian. The treatment of 3N interactions without approximations allows for first studies of the dependence of nuclear-structure observables on the details of chiral interactions. Moreover, we present results for heavy nuclei obtained in Coupled Cluster calculations using a normal-ordered two-body approximation of the 3N interaction.
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- 2024
29. Multidisciplinary Approach to Patients With Metastatic Spinal Cord Compression: A Diagnostic Therapeutic Algorithm to Improve the Neurological Outcome
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Rossella Rispoli, Chiara Reverberi, Giada Targato, Serena D’Agostini, Gianpiero Fasola, Marco Trovò, Mario Calci, Renato Fanin, and Barbara Cappelletto
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spinal metastasis ,spinal cord compression ,pathological spine fractures ,diagnostic-therapeutic algorithm ,neurological deficits ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionThe morbidity associated with metastatic spinal disease is significant because of spinal cord and/or nerve root compression. The purpose of this paper is to define a diagnostic-therapeutic path for patients with vertebral metastases and from this path to build an algorithm to reduce the devastating consequences of spinal cord compression.Materials and MethodsThe algorithm is born from the experience of a primary care center. A spine surgeon, an emergency room (ER) physician, a neuroradiologist, a radiation oncologist, and an oncologist form the multidisciplinary team. The ER physician or the oncologist intercept the patient with symptoms and signs of a metastatic spinal cord compression. Once the suspicion is confirmed, the following steps of the flow-chart must be triggered. The spine surgeon takes charge of the patient and, on the base of the anamnestic data and neurological examination, defines the appropriate timing for magnetic resonance imaging (MRI) in collaboration with the neuroradiologist. From the MRI outcome, the spine surgeon and the radiation oncologist consult each other to define further therapeutic alternatives. If indicated, surgical treatment should precede radiation therapy. The oncologist gets involved after surgery for systemic therapy.ResultsIn 2021, the Spine and Spinal Cord Surgery department evaluated 257 patients with vertebral metastasis. Fifty-three patients presented with actual or incipient spinal cord compression. Among these, 27 were admitted due to rapid progression of symptoms, neurological deficits and/or spine instability signs. The level was thoracic in 21 cases, lumbar in 4 cases, cervical in 1 case, sacral in 1 case. Fifteen were operated on, 10 of these programmed and 5 in emergency.DiscussionPatients with a history of malignancy can present to the ER or to the oncology department with symptoms that must be correctly framed in the context of a metastatic involvement. Even when there is no previous cancer history, the patient’s pain characteristics and clinical signs must be interpreted to yield the correct diagnosis of vertebral metastasis with incipient or current spinal cord compression. The awareness of the alert symptoms and the application of an integrated paradigm consent to frame the patients with spinal cord compression, obtaining the benefits of a homogeneous step-by-step diagnostic and therapeutic path. Early surgical or radiation therapy treatment gives the best hope for preventing the worsening, or even improving, the deficits.ConclusionsMetastatic spinal cord compression can cause neurological deficits compromising quality of life. Treatment strategies should be planned comprehensively. A multidisciplinary approach and the application of the proposed algorithm is of paramount importance to optimize the outcomes of these patients.
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- 2022
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30. Open-Shell Nuclei and Excited States from Multi-Reference Normal-Ordered Hamiltonians
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Gebrerufael, Eskendr, Calci, Angelo, and Roth, Robert
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Nuclear Theory - Abstract
We discuss the approximate inclusion of three-nucleon interactions into ab initio nuclear structure calculations using a multi-reference formulation of normal ordering and Wick's theorem. Following the successful application of single-reference normal ordering for the study of ground states of closed-shell nuclei, e.g., in coupled-cluster theory, multi-reference normal ordering opens a path to open-shell nuclei and excited states. Based on different multi-determinantal reference states we benchmark the truncation of the normal-ordered Hamiltonian at the two-body level in no-core shell-model calculations for p-shell nuclei, including 6-Li, 12-C, and 10-B. We find that this multi-reference normal-ordered two-body approximation is able to capture the effects of the 3N interaction with sufficient accuracy, both, for ground-state and excitation energies, at the computational cost of a two-body Hamiltonian. It is robust with respect to the choice of reference states and has a multitude of applications in ab initio nuclear structure calculations of open-shell nuclei and their excitations as well as in nuclear reaction studies., Comment: 6 pages, 4 figures, v2: update to published version
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- 2015
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31. Ab initio calculations of reactions with light nuclei
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Quaglioni, S., Hupin, G., Calci, A., Navratil, P., and Roth, R.
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Nuclear Theory - Abstract
An {\em ab initio} (i.e., from first principles) theoretical framework capable of providing a unified description of the structure and low-energy reaction properties of light nuclei is desirable to further our understanding of the fundamental interactions among nucleons, and provide accurate predictions of crucial reaction rates for nuclear astrophysics, fusion-energy research, and other applications. In this contribution we review {\em ab initio} calculations for nucleon and deuterium scattering on light nuclei starting from chiral two- and three-body Hamiltonians, obtained within the framework of the {\em ab initio} no-core shell model with continuum. This is a unified approach to nuclear bound and scattering states, in which square-integrable energy eigenstates of the $A$-nucleon system are coupled to $(A-a)+a$ target-plus-projectile wave functions in the spirit of the resonating group method to obtain an efficient description of the many-body nuclear dynamics both at short and medium distances and at long ranges., Comment: 9 pages, 5 figures, proceedings of the 21st International Conference on Few-Body Problems in Physics
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- 2015
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32. Ab Initio No Core Shell Model - Recent Results and Further Prospects
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Vary, James P., Maris, Pieter, Potter, Hugh, Caprio, Mark A., Smith, Robin, Binder, Sven, Calci, Angelo, Fischer, Sebastian, Langhammer, Joachim, Roth, Robert, Aktulga, Hasan Metin, Ng, Esmond, Yang, Chao, Oryspayev, Dossay, Sosonkina, Masha, Saule, Erik, and Çatalyürek, Ümit
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Nuclear Theory - Abstract
There has been significant recent progress in solving the long-standing problems of how nuclear shell structure and collective motion emerge from underlying microscopic inter-nucleon interactions. We review a selection of recent significant results within the ab initio No Core Shell Model (NCSM) closely tied to three major factors enabling this progress: (1) improved nuclear interactions that accurately describe the experimental two-nucleon and three-nucleon interaction data; (2) advances in algorithms to simulate the quantum many-body problem with strong interactions; and (3) continued rapid development of high-performance computers now capable of performing $20 \times 10^{15}$ floating point operations per second. We also comment on prospects for further developments., Comment: Invited paper presented at NTSE-2014 and published online in the proceedings (see footnote on p.1)
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- 2015
33. A Generalization of $J$-Quasipolar Rings
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Calci, T. Pekacar, Halicioglu, S., and Harmanci, A.
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Mathematics - Rings and Algebras ,16S50, 16S70, 16U99 - Abstract
In this paper, we introduce a class of quasipolar rings which is a generalization of $J$-quasipolar rings. Let $R$ be a ring with identity. An element $a \in R$ is called {\it $\delta$-quasipolar} if there exists $p^2 = p\in comm^2(a)$ such that $a + p$ is contained in $\delta(R)$, and the ring $R$ is called {\it $\delta$-quasipolar} if every element of $R$ is $\delta$-quasipolar. We use $\delta$-quasipolar rings to extend some results of $J$-quasipolar rings. Then some of the main results of $J$-quasipolar rings are special cases of our results for this general setting. We give many characterizations and investigate general properties of $\delta$-quasipolar rings., Comment: Submitted for publication
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- 2015
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34. A Class of $J$-quasipolar Rings
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Calci, M. B., Halicioglu, S., and Harmanci, A.
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Mathematics - Rings and Algebras ,16S50, 16S70, 16U99 - Abstract
In this paper, we introduce a class of $J$-quasipolar rings. Let $R$ be a ring with identity. An element $a$ of a ring $R$ is called {\it weakly $J$-quasipolar} if there exists $p^2 = p\in comm^2(a)$ such that $a + p$ or $a-p$ are contained in $J(R)$ and the ring $R$ is called {\it weakly $J$-quasipolar} if every element of $R$ is weakly $J$-quasipolar. We give many characterizations and investigate general properties of weakly $J$-quasipolar rings. If $R$ is a weakly $J$-quasipolar ring, then we show that (1) $R/J(R)$ is weakly $J$-quasipolar, (2) $R/J(R)$ is commutative, (3) $R/J(R)$ is reduced. We use weakly $J$-quasipolar rings to obtain more results for $J$-quasipolar rings. We prove that the class of weakly $J$-quasipolar rings lies between the class of $J$-quasipolar rings and the class of quasipolar rings. Among others it is shown that a ring $R$ is abelian weakly $J$-quasipolar if and only if $R$ is uniquely clean., Comment: Submitted for publication
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- 2015
35. Few-nucleon systems with state-of-the-art chiral nucleon-nucleon forces
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Binder, S., Calci, A., Epelbaum, E., Furnstahl, R. J., Golak, J., Hebeler, K., Kamada, H., Krebs, H., Langhammer, J., Liebig, S., Maris, P., Meißner, U. -G., Minossi, D., Nogga, A., Potter, H., Roth, R., Skibinski, R., Topolnicki, K., Vary, J. P., and Witala, H.
- Subjects
Nuclear Theory - Abstract
We apply improved nucleon-nucleon potentials up to fifth order in chiral effective field theory, along with a new analysis of the theoretical truncation errors, to study nucleon-deuteron (Nd) scattering and selected low-energy observables in 3H, 4He, and 6Li. Calculations beyond second order differ from experiment well outside the range of quantified uncertainties, providing truly unambiguous evidence for missing three-nucleon forces within the employed framework. The sizes of the required three-nucleon force contributions agree well with expectations based on Weinberg's power counting. We identify the energy range in elastic Nd scattering best suited to study three-nucleon force effects and estimate the achievable accuracy of theoretical predictions for various observables., Comment: 5 pages, 5 figures
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- 2015
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36. Accelerating Ab Initio Nuclear Physics Calculations with GPUs
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Potter, Hugh, Oryspayev, Dossay, Maris, Pieter, Sosonkina, Masha, Vary, James, Binder, Sven, Calci, Angelo, Langhammer, Joachim, Roth, Robert, Çatalyürek, Ümit, and Saule, Erik
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Physics - Computational Physics ,Nuclear Theory - Abstract
This paper describes some applications of GPU acceleration in ab initio nuclear structure calculations. Specifically, we discuss GPU acceleration of the software package MFDn, a parallel nuclear structure eigensolver. We modify the matrix construction stage to run partly on the GPU. On the Titan supercomputer at the Oak Ridge Leadership Computing Facility, this produces a speedup of approximately 2.2x - 2.7x for the matrix construction stage and 1.2x - 1.4x for the entire run., Comment: 9 pages, 4 figures
- Published
- 2014
37. SARS-CoV-2 wastewater variant surveillance: pandemic response leveraging FDA's GenomeTrakr network.
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Timme, Ruth E., Woods, Jacquelina, Jones, Jessica L., Calci, Kevin R., Rodriguez, Rachel, Barnes, Candace, Leard, Elizabeth, Craven, Mark, Haifeng Chen, Boerner, Cameron, Grim, Christopher, Windsor, Amanda M., Ramachandran, Padmini, Muruvanda, Tim, Rand, Hugh, Tesfaldet, Bereket, Amirzadegan, Jasmine, Kayikcioglu, Tunc, Walsky, Tamara, and Allard, Marc
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- 2024
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38. Continuum and Three-Nucleon Force Effects on 9Be Energy Levels
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Langhammer, Joachim, Navratil, Petr, Quaglioni, Sofia, Hupin, Guillaume, Calci, Angelo, and Roth, Robert
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Nuclear Theory - Abstract
We extend the recently proposed ab initio no-core shell model with continuum to include three-nucleon (3N) interactions beyond the few-body domain. The extended approach allows for the assessment of effects of continuum degrees of freedom as well as of the 3N force in ab initio calculations of structure and reaction observables of p- and lower-sd-shell nuclei. As first application we concentrate on energy levels of the 9Be system for which all excited states lie above the n-8Be threshold. For all energy levels, the inclusion of the continuum significantly improves the agreement with experiment, which was an issue in standard no-core shell model calculations. Furthermore, we find the proper treatment of the continuum indispensable for reliable statements about the quality of the adopted 3N interaction from chiral effective field theory. In particular, we find the 1/2+ resonance energy, which is of astrophysical interest, in good agreement with experiment., Comment: 6 pages, 5 figures
- Published
- 2014
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39. Low-energy neutron-deuteron reactions with N3LO chiral forces
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Golak, J., Skibinski, R., Topolnicki, K., Witala, H., Epelbaum, E., Krebs, H., Kamada, H., Meißner, Ulf-G., Bernard, V., Maris, P., Vary, J., Binder, S., Calci, A., Hebeler, K., Langhammer, J., Roth, R., Nogga, A., Liebig, S., and Minossi, D.
- Subjects
Nuclear Theory - Abstract
We solve three-nucleon Faddeev equations with nucleon-nucleon and three-nucleon forces derived consistently in the framework of chiral perturbation theory at next-to-next-to-next-to-leading order in the chiral expansion. In this first investigation we include only matrix elements of the three-nucleon force for partial waves with the total two-nucleon (three-nucleon) angular momenta up to 3 (5/2). Low-energy neutron-deuteron elastic scattering and deuteron breakup reaction are studied. Emphasis is put on Ay puzzle in elastic scattering and cross sections in symmetric-space-star and neutron-neutron quasi-free-scattering breakup configurations, for which large discrepancies between data and theory have been reported., Comment: 22 pages, 7 figures
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- 2014
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40. Ab Initio Multi-Reference In-Medium Similarity Renormalization Group Calculations of Even Calcium and Nickel Isotopes
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Hergert, H., Bogner, S. K., Morris, T. D., Binder, S., Calci, A., Langhammer, J., and Roth, R.
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Nuclear Theory ,Nuclear Experiment - Abstract
We use the newly developed Multi-Reference In-Medium Similarity Renormalization Group to study all even isotopes of the calcium and nickel isotopic chains, based on two- plus three-nucleon interactions derived from chiral effective field theory. We present results for ground-state and two-neutron separation energies and quantify their theoretical uncertainties. At shell closures, we find excellent agreement with Coupled Cluster results obtained with the same Hamiltonians. Our results highlight the importance of the chiral 3N interaction to obtain a correct reproduction of experimental energy trends, and their subtle impact on the location of the neutron drip lines in the Ca and Ni chains. At the same time, we uncover and discuss deficiencies of the input Hamiltonians which need to be addressed by the next generation of chiral interactions., Comment: 7 pages, 5 figures
- Published
- 2014
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41. Ab Initio study of neutron drops with chiral Hamiltonians
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Potter, H. D., Fischer, S., Maris, P., Vary, J. P., Binder, S., Calci, A., Langhammer, J., and Roth, R.
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Nuclear Theory - Abstract
We report ab initio calculations for neutron drops in a 10 MeV external harmonic-oscillator trap using chiral nucleon-nucleon plus three-nucleon interactions. We present total binding energies, internal energies, radii and odd-even energy differences for neutron numbers N = 2 - 18 using the no-core shell model with and without importance truncation. Furthermore, we present total binding energies for N = 8, 16, 20, 28, 40, 50 obtained in a coupled-cluster approach. Comparisons with Green's Function Monte Carlo results, where available, using Argonne v8' with three-nucleon interactions reveal important dependences on the chosen Hamiltonian., Comment: 7 pages, 5 figures
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- 2014
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42. $^{12}$C properties with evolved chiral three-nucleon interactions
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Maris, P., Vary, J. P., Calci, A., Langhammer, J., Binder, S., and Roth, R.
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Nuclear Theory - Abstract
We investigate selected static and transition properties of $^{12}$C using ab initio No-Core Shell Model (NCSM) methods with chiral two- and three-nucleon interactions. We adopt the Similarity Renormalization Group (SRG) to assist convergence including up to three-nucleon (3N) contributions. We examine the dependences of the $^{12}$C observables on the SRG evolution scale and on the model-space parameters. We obtain nearly converged low-lying excitation spectra. We compare results of the full NCSM with the Importance Truncated NCSM in large model spaces for benchmarking purposes. We highlight the effects of the chiral 3N interaction on several spectroscopic observables. The agreement of some observables with experiment is improved significantly by the inclusion of 3N interactions, e.g., the B(M1) from the first $J^\pi T = 1^+ 1$ state to the ground state. However, in some cases the agreement deteriorates, e.g., for the excitation energy of the first $1^+ 0$ state, leaving room for improved next-generation chiral Hamiltonians., Comment: 11 pages, 9 figures
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- 2014
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43. Ab Initio Description of p-Shell Hypernuclei
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Wirth, Roland, Gazda, Daniel, Navrátil, Petr, Calci, Angelo, Langhammer, Joachim, and Roth, Robert
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Nuclear Theory ,Astrophysics - Solar and Stellar Astrophysics ,High Energy Physics - Phenomenology - Abstract
We present the first ab initio calculations for p-shell single-Lambda hypernuclei. For the solution of the many-baryon problem, we develop two variants of the no-core shell model with explicit $\Lambda$ and $\Sigma^+$, $\Sigma^0$, $\Sigma^-$ hyperons including $\Lambda$-$\Sigma$ conversion, optionally supplemented by a similarity renormalization group transformation to accelerate model-space convergence. In addition to state-of-the-art chiral two- and three-nucleon interactions, we use leading-order chiral hyperon-nucleon interactions and a recent meson-exchange hyperon-nucleon interaction. We validate the approach for s-shell hypernuclei and apply it to p-shell hypernuclei, in particular to $^7_\Lambda$Li, $^9_\Lambda$Be and $^{13}_\Lambda$C. We show that the chiral hyperon-nucleon interactions provide ground-state and excitation energies that agree with experiment within the cutoff dependence. At the same time we demonstrate that hypernuclear spectroscopy provides tight constraints on the hyperon-nucleon interactions and we discuss the impact of induced hyperon-nucleon-nucleon interactions., Comment: 6 pages, 4 figures
- Published
- 2014
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44. Nonperturbative shell-model interactions from the in-medium similarity renormalization group
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Bogner, S. K., Hergert, H., Holt, J. D., Schwenk, A., Binder, S., Calci, A., Langhammer, J., and Roth, R.
- Subjects
Nuclear Theory ,Nuclear Experiment - Abstract
We present the first ab initio construction of valence-space Hamiltonians for medium-mass nuclei based on chiral two- and three-nucleon interactions using the in-medium similarity renormalization group. When applied to the oxygen isotopes, we find experimental ground-state energies are well reproduced, including the flat trend beyond the drip line at 24O. Similarly, natural-parity spectra in 21,22,23,24O are in agreement with experiment, and we present predictions for excited states in 25,26O. The results exhibit a weak dependence on the harmonic-oscillator basis parameter and reproduce spectroscopy within the standard sd valence space., Comment: 6 pages, 5 figures, published version
- Published
- 2014
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45. Progress on Light-Ion Fusion Reactions with Three-Nucleon Forces
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Hupin, Guillaume, Quaglioni, Sofia, Langhammer, Joachim, Navrátil, Petr, Calci, Angelo, and Roth, Robert
- Subjects
Nuclear Theory - Abstract
The description of structural and dynamical properties of nuclei starting from the fundamental interaction between nucleons has been a long-standing goal in nuclear physics. The ab initio No-Core Shell Model combined with the Resonating-Group Method (NCSM/RGM) is capable of addressing both structural and reaction properties of light-nuclei. While promising results have already been achieved starting from a two-body Hamiltonian, a truly realistic prediction of nuclear observables requires the treatment of the three-nucleon interaction. Using similarity-renormalization-group evolved two- and three-nucleon interactions, we will present recent applications to n-4He scattering process when accounting for the chiral two- plus three-nucleon interaction versus the chiral two-nucleon interaction. We compare our results to phase shifts obtained from R-matrix analysis of data up to 16 MeV neutron energy, below the d-3H threshold., Comment: 4 pages, 2 figures, Proceedings of the 22nd European Conference on Few-Body Problems in Physics, Krakow, Poland, 9-13 September 2013
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- 2014
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46. Ab Initio Path to Heavy Nuclei
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Binder, Sven, Langhammer, Joachim, Calci, Angelo, and Roth, Robert
- Subjects
Nuclear Theory - Abstract
We present the first ab initio calculations of nuclear ground states up into the domain of heavy nuclei, spanning the range from 16-O to 132-Sn based on two- plus three-nucleon interactions derived within chiral effective field theory. We employ the similarity renormalization group for preparing the Hamiltonian and use coupled-cluster theory to solve the many-body problem for nuclei with closed sub-shells. Through an analysis of theoretical uncertainties resulting from various truncations in this framework, we identify and eliminate the technical hurdles that previously inhibited the step beyond medium-mass nuclei, allowing for reliable validations of nuclear Hamiltonians in the heavy regime. Following this path we show that chiral Hamiltonians qualitatively reproduce the systematics of nuclear ground-state energies up to the neutron-rich Sn isotopes., Comment: 5 pages, 5 figures
- Published
- 2013
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47. Prime structures in a Morita context
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Calci, Mete Burak, Halicioglu, Sait, Harmanci, Abdullah, and Ungor, Burcu
- Published
- 2020
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48. Evolved Chiral NN+3N Hamiltonians for Ab Initio Nuclear Structure Calculations
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Roth, Robert, Calci, Angelo, Langhammer, Joachim, and Binder, Sven
- Subjects
Nuclear Theory - Abstract
We discuss the building blocks for a consistent inclusion of chiral three-nucleon (3N) interactions into ab initio nuclear structure calculations beyond the lower p-shell. We highlight important technical developments, such as the similarity renormalization group (SRG) evolution in the 3N sector, a JT-coupled storage scheme for 3N matrix elements with efficient on-the-fly decoupling, and the importance truncated no-core shell model with 3N interactions. Together, these developments make converged ab initio calculations with explicit 3N interactions possible also beyond the lower p-shell. We analyze in detail the impact of various truncations of the SRG-evolved Hamiltonian, in particular the truncation of the harmonic-oscillator model space used for solving the SRG flow equations and the omission of the induced beyond-3N contributions of the evolved Hamiltonian. Both truncations lead to sizable effects in the upper p-shell and beyond and we present options to remedy these truncation effects. The analysis of the different truncations is a first step towards a systematic uncertainty quantification of all stages of the calculation., Comment: 21 pages, 16 figures, 2 tables
- Published
- 2013
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49. Extension of coupled-cluster theory with a non-iterative treatment of connected triply excited clusters to three-body Hamiltonians
- Author
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Binder, Sven, Piecuch, Piotr, Calci, Angelo, Langhammer, Joachim, Navrátil, Petr, and Roth, Robert
- Subjects
Nuclear Theory - Abstract
We generalize the coupled-cluster (CC) approach with singles, doubles, and the non-iterative treatment of triples termed $\Lambda$CCSD(T) to Hamiltonians containing three-body interactions. The resulting method and the underlying CC approach with singles and doubles only (CCSD) are applied to the medium-mass closed-shell nuclei O16, O24, and Ca40. By comparing the results of CCSD and $\Lambda$CCSD(T) calculations with explicit treatment of three-nucleon interactions to those obtained using an approximate treatment in which they are included effectively via the zero-, one-, and two-body components of the Hamiltonian in normal-ordered form, we quantify the contributions of the residual three-body interactions neglected in the approximate treatment. We find these residual normal-ordered three-body contributions negligible for the $\Lambda$CCSD(T) method, although they can become significant in the lower-level CCSD approach, particularly when the nucleon-nucleon interactions are soft., Comment: 21 pages, 3 figures
- Published
- 2013
- Full Text
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50. Ab initio many-body calculations of nucleon-4He scattering with three-nucleon forces
- Author
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Hupin, Guillaume, Langhammer, Joachim, Navrátil, Petr, Quaglioni, Sofia, Calci, Angelo, and Roth, Robert
- Subjects
Nuclear Theory - Abstract
We extend the ab initio no-core shell model/resonating-group method to include three-nucleon (3N) interactions for the description of nucleon-nucleus collisions. We outline the formalism, give algebraic expressions for the 3N-force integration kernels, and discuss computational aspects of two alternative implementations. The extended theoretical framework is then applied to nucleon-4He scattering using similarity-renormalization-group (SRG) evolved nucleon-nucleon plus three-nucleon potentials derived from chiral effective field theory. We analyze the convergence properties of the calculated phase shifts and explore their dependence upon the SRG evolution parameter. We include up to six excited states of the 4He target and find significant effects from the inclusion of the chiral 3N force, e.g., it enhances the spin-orbit splitting between the 3/2- and 1/2- resonances and leads to an improved agreement with the phase shifts obtained from an accurate R-matrix analysis of the five-nucleon experimental data. We find remarkably good agreement with measured differential cross sections at various energies, while analyzing powers manifest larger deviations from experiment for certain energies and angles., Comment: 18 pages, 12 figures
- Published
- 2013
- Full Text
- View/download PDF
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