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19 results on '"Calavia, Olga"'

1. T-Cell Immune Responses in Newborns and Long-Term Sequelae in Congenital Cytomegalovirus Infection (CYTRIC Study)

Author

Hernández, Judith, Pisón, Raquel Pinillos, Arnaiz, Eneritz Velasco, Villaverde, Serena, Vila, Sara, Rojo, Pablo, Epalza, Cristina, Moraleda, Cinta, Cooke, Elisa Fernández, Prieto, Luis, Zamora, Berta, Martínez de Aragón, Ana, Simón, Rogelio, Camacho, Ana, Machín, Fátima, Cabello, Laura, Romero, María Luz, Serna, Miquel, Martín, Marta, Esquivel-De la Fuente, Estrella, Calle, María de la, Rodríguez, Sara Domínguez, Cabanes, María, Gómez-Montes, Enery, Goncé, Anna, Bango, Marta Valdés, Viñuela-Benéitez, M<ce:sup loc='post">a</ce:sup> Carmen, Muñoz-Chápuli Gutiérrez, Mar, Pérez, Irene Cuadrado, Encinas, Begoña, Tagarro, Alfredo, Alcázar, Diana García, Burguillo, Antonio García, Martín, Roser Díez, Calavia, Olga, Salvia, Dolors, Olabarrieta, Iciar, Xiberta, Joan Manel, Jiménez Losa, Luz María, Soriano-Ramos, María, Pedrero-Tomé, Roberto, Giménez-Quiles, Estela, Albert, Eliseo, Baquero-Artigao, Fernando, Rodríguez-Molino, Paula, del Rosal, Teresa, Noguera-Julian, Antoni, Fortuny, Clàudia, Ríos-Barnés, María, Saavedra-Lozano, Jesús, Dueñas, Eva, Sánchez-Mateos, Miguel, Castells, Laura, de la Serna, María, Frick, Marie Antoinette, de Vergas, Joaquín, Núñez-Enamorado, Noemí, Moral-Pumarega, María Teresa, Folgueira, María Dolores, Navarro, David, and Blázquez-Gamero, Daniel

Published
2024
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2. Multisystem inflammatory syndrome in children and SARS-CoV-2 variants: a two-year ambispective multicentric cohort study in Catalonia, Spain

Author

Pino, Rosa, Antoñanzas, Jesús M., Paredes-Carmona, Fernando, Perramon, Aida, Rivière, Jacques G., Coma, Maria, Martínez-Mejías, Abel, Ripoll, Francesc, López, Núria, Conti, Romina, Sala-Castellví, Pere, Ruiz, Montserrat, Brio, Sonia, García-Lorenzo, Marc, Esteller, Maria, Carreras-Abad, Clara, Herrero-Hernando, Carlos, Schneider, Stephan Otto, Gatell, Anna, Aguilar, Isabel, Cantero, Javier, Ruiz, Gloria, Fenollosa, Teresa, Lobato, Zulema, Villalobos, Pilar, Mora, Emiliano, Anton, Jordi, Visa-Reñé, Núria, Soler-Palacin, Pere, Calavia, Olga, Esquirol-Herrero, Cristina, Guarch-Ibañez, Borja, García-García, Juan-José, Coma, Ermengol, Fina, Francesc, Prats, Clara, and Soriano-Arandes, Antoni

Published
2023
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3. The Value of the Second QuantiFERON-TB Gold-Plus Antigen Tube at Diagnosis and at Treatment Completion in Spanish Children With Tuberculosis

Author

Soler-Garcia, Aleix, Gamell, Anna, Monsonís, Manuel, Korta-Murua, José Javier, Espiau, María, Rincón-López, Elena, Rodríguez-Molino, Paula, Pérez-Porcuna, Tomàs, Bustillo-Alonso, Matilde, Santiago, Begoña, Tebruegge, Marc, Noguera-Julian, Antoni, AZURMENDI-GUNDÍN, Nerea, FORTUNY, Clàudia, COLINO, Elena, GÓMEZ-PASTRANA, David, MONTERO, María, PEROMINGO, Estrella, LAFUENTE-HIDALGO, Miguel, MOLINER, Elisenda, VALMANYA, Teresa, MINGUELL-DOMINGO, Laura, FENOY, Marina, VELÁZQUEZ, Marta, SOLER-CAMPINS, Maria Queralt, GARCIA, Lourdes, LAHOZ, Rebeca, CALAVIA, Olga, PASCUAL, María Teresa, RIUS, Neus, TÓRTOLA, Teresa, SORIANO-ARANDES, Antoni, MARTÍN-NALDA, Andrea, SOLER-PALACÍN, Pere, LILLO, Miguel, DAPENA, Marta, LÓPEZ-MEDINA, Eva María, PIQUERAS, Ana Isabel, RUIZ-JIMÉNEZ, Marta, SOTO-SÁNCHEZ, Beatriz, HERNÁNDEZ, Ángel, RUIZ-SERRANO, María Jesús, COBO-VÁZQUEZ, Elvira, SANTOS, María del Mar, HERNÁNDEZ-SAMPELAYO, Teresa, TAGARRO, Alfredo, MÉNDEZ-ECHEVARRÍA, Ana, MELLADO, María José, BAQUERO-ARTIGAO, Fernando, CALVO, Cristina, SAINZ, Talía, ÁLVAREZ, Javier, GARCÍA ASCASO, Marta Taida, VILLALOBOS, Enrique, PÉREZ-GORRICHO, Beatriz, GARCÍA-GARCÍA, María Luz, GARROTE-LLANOS, Maria Isabel, REMENTERÍA, Joseba, SÁNCHEZ-TORRENT, Laia, GARCÍA-HORTELANO, Milagros, and LOBATO, Zulema

Published
2023
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4. Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children

Author

Vallmanya, Teresa, Minguell, Laura, Martín-Nalda, Andrea, Soler-Palacín, Pere, Espiau, María, Lobato, Zulema, Garcia, Lourdes, Velázquez, Marta, Herranz, Mercedes, Arroyo, Mireia, Gutiérrez, Carmelo, Gavilán, César, Piqueras, Ana Isabel, Martinón-Torres, Federico, Villanueva, Isabel, Rueda, Santiago, Ramos, Marta Illán, Morales, Ana, ROA, Miguel, Pérez-Gorricho, Beatriz, Pinto, Enrique Villalobos, Sanz-Santaeufemia, Francisco José, Álvarez, Javier, Álvarez, Cristina, Guarch, Borja, Montero, María, Cilleruelo, María José, Otheo, Enrique, Calvo, Cristina, Korta Murua, José Javier, Mellado, María José, Rojo, Pablo, Moreno-Pérez, David, Neth, Olaf, Santos, Mar, Hernández, Teresa, Hidalgo, Miguel Lafuente, Antonio Cepillo, Martínez-Planas, Aina, Baquero-Artigao, Fernando, Santiago, Begoña, Fortuny, Clàudia, Méndez-Echevarría, Ana, Del Rosal, Teresa, Bustillo-Alonso, Matilde, Gale, Inés, Guerrero, Carmelo, Blázquez-Gamero, Daniel, Canet, Anna, Lillo, Miguel, Calavia, Olga, Núñez Cuadros, Esmeralda, Falcón-Neyra, Lola, Soriano-Arandes, Antoni, Van Ingen, Jakko, Tebruegge, Marc, and Noguera-Julian, Antoni

Published
2021
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5. Novel frameshift variants expand the map of the genetic defects in IRF2BP2

Author

García-Aznar, José María, primary, Maneiro Pampín, Emilia, additional, García Ramos, Maite, additional, Acuña Pérez, María José, additional, Paz Gandiaga, Nerea, additional, Minguell Domingo, Laura, additional, Calavia, Olga, additional, Soler-Palacin, Pere, additional, Colobran, Roger, additional, Novoa Bolívar, Erika M., additional, and Ocejo Vinyals, Javier Gonzalo, additional

Published
2023
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6. Prevalence and Clinical Characteristics of Children With Nonsevere Tuberculosis in Spain

Author

Hernanz-Lobo, Alicia, Noguera-Julián, Antoni, Minguell, Laura, López-Suárez, Andrea, Soriano-Arandes, Antoni, Espiau, María, Colino, Elena, López Medina, Eva María, Bustillo Alonso, Matilde, Aguirre-Pascual, Elisa, Baquero-Artigao, Fernando, Calavia, Olga, Gómez-Pastrana, David, Falcón Neyra, Lola, Santiago-García, Begoña, Hernanz-Lobo, Alicia, Noguera-Julián, Antoni, Minguell, Laura, López-Suárez, Andrea, Soriano-Arandes, Antoni, Espiau, María, Colino, Elena, López Medina, Eva María, Bustillo Alonso, Matilde, Aguirre-Pascual, Elisa, Baquero-Artigao, Fernando, Calavia, Olga, Gómez-Pastrana, David, Falcón Neyra, Lola, and Santiago-García, Begoña

Abstract

Background: To assess the prevalence and characteristics of nonsevere TB among children in Spain. It has been recently demonstrated that these children can be treated with a 4-month regimen instead of the classical 6-month treatment regimen, with the same effectivity and outcomes, decreasing toxicity and improving adherence. Methods: We conducted a retrospective cohort study in a cohort of children ≤16 years of age with TB. Nonsevere TB cases included smear-negative children with respiratory TB confined to 1 lobe, with no significant airway obstruction, no complex pleural effusion, no cavities and no signs of miliary disease, or with peripheral lymph-node disease. The remaining children were considered to have severe TB. We estimated the prevalence of nonsevere TB and compared the clinical characteristics and outcomes between children with nonsevere and severe TB. Results: A total of 780 patients were included [46.9% males, median age 5.5 years (IQR: 2.6–11.1)], 477 (61.1%) of whom had nonsevere TB. Nonsevere TB was less frequent in children <1 year (33% vs 67%; P < 0.001), and >14 years of age (35% vs 65%; P = 0.002), mostly diagnosed in contact tracing studies (60.4% vs 29.2%; P < 0.001) and more frequently asymptomatic (38.3% vs 17.7%; P < 0.001). TB confirmation in nonsevere disease was less frequent by culture (27.0% vs 57.1%; P < 0.001) and by molecular tests (18.2% vs 48.8%; P < 0.001). Sequelae were less frequent in children with nonsevere disease (1.7 vs 5.4%; P < 0.001). No child with nonsevere disease died. Conclusions: Two-thirds of children had nonsevere TB, mostly with benign clinical presentation and negative microbiologic results. In low-burden countries, most children with TB might benefit from short-course regimens.

Published
2023

7. Novel frameshift variants expand the map of the genetic defects in IRF2BP2.

Author

María García-Aznar, José, Maneiro Pampín, Emilia, García Ramos, Maite, Acuña Pérez, María José, Paz Gandiaga, Nerea, Minguell Domingo, Laura, Calavia, Olga, Soler-Palacin, Pere, Colobran, Roger, Novoa Bolívar, Erika M., and Ocejo Vinyals, Javier Gonzalo

Subjects
GAIN-of-function mutations, PRIMARY immunodeficiency diseases, NUCLEOTIDE sequencing, GENE mapping, GENETIC testing, GENETIC variation
Abstract

Background: At present, the knowledge about disease-causing mutations in IRF2BP2 is very limited because only a few patients affected by this condition have been reported. As previous studies have described, the haploinsufficiency of this interferon transcriptional corepressors leads to the development of CVID. Very recently, a more accurate phenotype produced by truncating variants in this gene has been defined, manifesting CVID with gastrointestinal inflammatory symptoms and autoimmune manifestations. Methods: We analyzed 5 index cases with suspected primary immunodeficiency by high throughput sequencing. They were submitted for a genetic test with a panel of genes associated with immune system diseases, including IRF2BP2. The screening of SNVs, indels and CNVs fulfilling the criteria with very low allelic frequency and high protein impact, revealed five novel variants in IRF2BP2. In addition, we isolated both wild-type and mutated allele of the cDNA from one of the families. Results: In this study, we report five novel loss-of-function (LoF) mutations in IRF2BP2 that likely cause primary immunodeficiency, with CVID as more frequent phenotype, variable expression of inflammatory gastrointestinal features, and one patient with predisposition of viral infection. All identified variants were frameshift changes, and one of them was a large deletion located on chromosome 1q42, which includes the whole sequence of IRF2BP2, among other genes. Both de novo and dominant modes of inheritance were observed in the families here presented, as well as incomplete penetrance. Conclusions: We describe novel variants in a delimited low-complex region, which may be considered a hotspot in IRF2BP2. Moreover, this is the first time that a large CNV in IRF2BP2 has been reported to cause CVID. The distinct mechanisms than LoF in IRF2BP2 could cause different phenotype compared with the mainly described. Further investigations are necessary to comprehend the regulatory mechanisms of IRF2BP2, which could be under variable expression of the disease. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Multisystem Inflammatory Syndrome in Children and SARS-CoV-2 variants: a two-year ambispective multicentric cohort study in Catalonia, Spain.

Author

Pino, Rosa, primary, Antoñanzas, Jesús M, additional, Paredes-Carmona, Fernando, additional, Perramon, Aida, additional, Rivière, Jacques G, additional, Coma, Maria, additional, Martínez-Mejías, Abel, additional, Ripoll, Francesc, additional, López, Nuria, additional, Conti, Romina, additional, Sala, Pere, additional, Ruiz, Montserrat, additional, Brio, Sonia, additional, García-Lorenzo, Marc, additional, Esteller, Maria, additional, Carreras-Abad, Clara, additional, Herrero-Hernando, Carlos, additional, Schneider, Stephan Otto, additional, Gatell, Anna, additional, Aguilar, Isabel, additional, Cantero, Javier, additional, Ruiz, Gloria, additional, Fenollosa, Teresa, additional, Lobato, Zulema, additional, Villalobos, Pilar, additional, Mora, Emiliano, additional, Anton, Jordi, additional, Visa-Reñé, Nuria, additional, Soler-Palacin, Pere, additional, Calavia, Olga, additional, Esqu, Cristina, additional, Guarch-Ibáñez, Borja, additional, García-García, Juan José, additional, Coma, Ermengol, additional, Fina, Francesc, additional, Prats, Clara, additional, and Soriano-Arandes, Antoni, additional

Published
2022
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9. Role of the Egami score to predict immunoglobulin resistance in Kawasaki disease among a Western Mediterranean population

Author

Sánchez-Manubens, Judith, Antón, Jordi, Bou, Rosa, Iglesias, Estíbaliz, Calzada-Hernandez, Joan, Borlan, Sergi, Gimenez-Roca, Clara, Rivera, Josefa, García, Lourdes, Caubet, Imma, Fàbrega, Jordi, Fernández, Anna, Alegre, Adolfo, Zambudio, Isabel, Delgado, Lluis, Garcia, Pablo, Serrano, Angelita, Sala, Pere, Villalobos, Pilar, Conradi, Álvaro Diaz, Agulló, Joan, Uriz, Socorro, Sánchez, Aina, Bonet, Mariona, Gispert-Saüch, Montserrat, Corral, Sonia, Lobato, Zulema, Domenech, Pere, Méndez, Maria, Calavia, Olga, Tobeña, Marc, Muñoz, Emiliano Mora, Sans, Gemma, Carrera, Montse, Mónaco, Ernesto, Ballester, Anna, Foguet, Anton, Escribano, Joaquín, Rius, Neus, Moral, Angel, Álvarez, Roser, Sorní, Toni, Molina, Vicente, Sanz, Mario, Terradas, Pilar, Salcedo, Salvador, Martínez, Olga, and the Kawasaki Disease in Catalonia Working Group

Published
2016
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10. Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?

Author

Alcobendas Rueda, Rosa M., Núñez, Esmeralda, Martín, Laura, Hernández, María Belén, Saavedra-Lozano, Jesús, Udaondo, Clara, Murias, Sara, Remesal, Agustin, Calvo, Cristina, Bustillo, Matilde, Lafuente, Miguel, Melendo, Susana, Vila, Jorgina, Clemente, Daniel, Sanz, Francisco José, Fumadó, Victoria, Ríos, María, María, Méndez, Menasalvas, Ana Isabel, García, Carmen, Fernández, Elisa, Calavia, Olga, Guarch, Borja, Garrote, Elisa, Camacho, Marisol, Falcón, Lola, Coll, María Teresa, Rius, Neus, Tagarro, Alfredo, Colino, Elena, Gavilán, César, Díaz, Rafael, Vázquez, Carmen, Lirola, María José, del Pozo, María, García, Lourdes, Monterde, Carla, Figueroa, Lucía, Bravo, Beatriz, Valle, Jose María, Salvador, Juan, Moreno, Carmen, Bueno, María Mercedes, Rivero, Irene, López, Agustín, García, María Jesús, Ranchal, Pilar, Pons, Sara, Callejas, Ignacio, Martínez, Leticia, Vázquez, Carmen, Domènech, Daniel, Ramakers, Jan, and Caldeiro, María Jesús

Published
2022
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11. Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

Author

Soler-Garcia, Aleix, primary, Gamell, Anna, additional, Santiago, Begoña, additional, Monsonís, Manuel, additional, Calvo, Cristina, additional, Cobo, Elvira, additional, Colino, Elena, additional, Espiau, María, additional, Guerrero-Laleona, Carmelo, additional, Lobato, Zulema, additional, Martín-Nalda, Andrea, additional, Pérez-Gorricho, Beatriz, additional, Perez-Porcuna, Tomas M., additional, Piqueras, Ana Isabel, additional, Rodríguez-Molino, Paula, additional, Ruiz, Marta, additional, Soriano-Arandes, Antoni, additional, Valmanya, Teresa, additional, Tebruegge, Marc, additional, Noguera-Julian, Antoni, additional, Gómez-Pastrana, David, additional, Montero, Maria, additional, Peromingo, Estrella, additional, Bustillo, Matilde, additional, Moliner, Elisenda, additional, Fenoy, Marina, additional, Velásquez, Marta, additional, Soler, Maria Queralt, additional, GARCÍA, Lourdes, additional, Calavia, Olga, additional, Rius, Neus, additional, Pascual, Maria Teresa, additional, Soler-Palacín, Pere, additional, Tórtola, Teresa, additional, Lillo, Miguel, additional, Dapena, Marta, additional, López-Medina, Eva María, additional, Santos, Maria del Mar, additional, Hernández, Ángel, additional, Hernández-Sanpelayo, Teresa, additional, Tagarro, Alfredo, additional, Méndez, Ana, additional, Mellado, María José, additional, Baquero-Artigao, Fernando, additional, Sainz, Talía, additional, García-Hortelano, Miluca, additional, Álvarez, Javier, additional, Villalobos, Enrique, additional, García-García, María Luz, additional, Garrote, María Isabel, additional, Korta Murua, José Javier, additional, Gundín, Nerea Azurmendi, additional, Sánchez-Torrent, Laia, additional, Velasco-Arnaiz, Eneritz, additional, and Fortuny, Clàudia, additional

Published
2020
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12. Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand

Author

Crichton, Siobhan, Belfrage, Eric, Collins, Intira Jeanne, Doerholt, Katja, Judd, Ali, Le Coeur, Sophie, Spoulou, Vana, Goodall, Ruth, Scherpbier, Henriette, Smit, Colette, Goetghebuer, Tessa, Gibb, Diana M., Noguera, Antoni, Luisa Navarro, Maria, Tomas Ramos, Jose, Galli, Luisa, Giaquinto, Carlo, Thorne, Claire, Santa Ansone, Marczynska, Magdalena, Okhonskaia, Liubov, de Tejada, Begona Martinez, Jourdain, Gonzague, Decker, Luc, Ene, Luminita, Hainaut, Marc, Van der Kelen, Evelyne, Delforge, Marc, de Martino, Maurizio, Tovo, Pier Angelo, Patrizia, Osimani, Larovere, Domenico, Ruggeri, Maurizio, Faldella, Giacomo, Baldi, Francesco, Badolato, Raffaele, Montagnani, Carlotta, Venturini, Elisabetta, Lisi, Catiuscia, Di Biagio, Antonio, Taramasso, Lucia, Giacomet, Vania, Erba, Paola, Esposito, Susanna, Lipreri, Rita, Salvini, Filippo, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, Lo Vecchio, Andrea, Rampon, Osvalda, Dona, Daniele, Romano, Amelia, Dodi, Icilio, Maccabruni, Anna, Consolini, Rita, Bernardi, Stefania, Kuekou, Hyppolite Tchidjou, Genovese, Orazio, Olmeo, Paolina, Cristiano, Letizia, Mazza, Antonio, Gabiano, Clara, Garazzino, Silvia, Pellegatta, Antonio, Pajkrt, D., Scherpbier, H. J., Weijsenfeld, A. M., de Boer, C. G., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E. G., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Pas, S. D., Henriet, S. S., V, van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Scholvinck, E. H., de Groot-de Jonge, H., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Bont, L. J., Geelen, S. P. M., Wolfs, T. F. W., Nauta, N., Schuurman, R., Verduyn-Lunel, F., Wensing, A. M. J., Reiss, P., Zaheri, S., Bezemer, D. O., van Sighem, A., I, Smit, C., Wit, F. W. M. N., Hillebregt, M., de Jong, A., Woudstra, T., Bergsma, D., Grivell, S., Meijering, R., Raethke, M., Rutkens, T., de Groot, L., van den Akker, M., Bakker, Y., Bezemer, M., El Berkaoui, A., Geerlinks, J., Koops, J., Kruijne, E., Lodewijk, C., Lucas, E., van der Meer, R., Munjishvili, L., Paling, E., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., van de Sande, L., Schoorl, M., Schnorr, P., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Witte, E. C., Tuk, B., Popielska, Jolanta, Pokorska-Spiewak, Maria, Oldakowska, Agnieszka, Zawadka, Konrad, Coupland, Urszula, Doroba, Malgorzata, Voronin, Evgeny, Miloenko, Milana, Labutina, Svetlana, Soler-Palacin, Pere, Antoinette Frick, Maria, Perez-Hoyos, Santiago, Mur, Antonio, Lopez, Nuria, Mendez, Maria, Mayol, Lluis, Vallmanya, Teresa, Calavia, Olga, Garcia, Lourdes, Coll, Maite, Pineda, Valenti, Rius, Neus, Rovira, Nuria, Duenas, Joaquin, Gamell, Anna, Fortuny, Claudia, Noguera-Julian, Antoni, Jose Mellado, Maria, Escosa, Luis, Garcia Hortelano, Milagros, Sainz, Talia, Isabel Gonzalez-Tome, Maria, Rojo, Pablo, Blazquez, Daniel, Prieto, Luis, Guillen, Sara, Saavedra, Jesus, Santos, Mar, Angeles Munoz, Ma, Ruiz, Beatriz, Fernandez Mc Phee, Carolina, Jimenez de Ory, Santiago, Alvarez, Susana, Angel Roa, Miguel, Beceiro, Jose, Martinez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Gomez Sirvent, Jorge, Garzon, Monica, Roman, Vicente, Montesdeoca, Abian, Mateo, Mercedes, Jose Munoz, Maria, Angulo, Raquel, Neth, Olaf, Falcon, Lola, Terol, Pedro, Luis Santos, Juan, Moreno, David, Lendinez, Francisco, Grande, Ana, Jose Romero, Francisco, Perez, Carlos, Lillo, Miguel, Losada, Begona, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Antonio Couceiro, Jose, Perez, Amparo, Isabel Piqueras, Ana, Breton, Rafael, Segarra, Inmaculada, Gavilan, Cesar, Jareno, Enrique, Montesinos, Elena, Dapena, Marta, Alvarez, Cristina, Gloria Andres, Ana, Marugan, Victor, Ochoa, Carlos, Alfayate, Santiago, Isabel Menasalvas, Ana, de Miguel, Elisa, Naver, Lars, Soeria-Atmadja, Sandra, Hagas, Vendela, Aebi-Popp, K., Anagnostopoulos, A., Asner, S., Battegay, M., Baumann, M., Bernasconi, E., Boni, J., Braun, D. L., Bucher, H. C., Calmy, A., Cavassini, M., Ciuffi, A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C. A., Grawe, C., Gunthard, H. F., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hosli, I, Huber, M., Kahlert, C. R., Kaiser, L., Keiser, O., Klimkait, T., Kottanattu, L., Kouyos, R. D., Kovari, H., Ledergerber, B., Martinetti, G., de Tejada, Martinez B., Marzolini, C., Metzner, K. J., Mueller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Polli, Ch, Rauch, A., Rudin, C., Scherrer, A. U., Schmid, P., Speck, R., Stockle, M., Tarr, P., Lecompte, Thanh M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Wyler, C. A., Yerly, S., Wannarit, Pornpun, Techakunakorn, Pornchai, Hansudewechakul, Rawiwan, Wanchaitanawong, Vanichaya, Theansavettrakul, Sookchai, Nanta, Sirisak, Ngampiyaskul, Chaiwat, Phanomcheong, Siriluk, Hongsiriwon, Suchat, Karnchanamayul, Warit, Kwanchaipanich, Ratchanee, Kanjanavanit, Suparat, Kamonpakorn, Nareerat, Nantarukchaikul, Maneeratn, Layangool, Prapaisri, Mekmullica, Jutarat, Lucksanapisitkul, Paiboon, Watanayothin, Sudarat, Lertpienthum, Narong, Warachit, Boonyarat, Hanpinitsak, Sansanee, Potchalongsin, Sathit, Thanasiri, Pimpraphai, Krikajornkitti, Sawitree, Attavinijtrakarn, Pornsawan, Srirojana, Sakulrat, Bunjongpak, Suthunya, Puangsombat, Achara, Na-Rajsima, Sathaporn, Ananpatharachai, Pornchai, Akarathum, Noppadon, Lawtongkum, Weerasak, An, Prapawan Kheunj, Suriyaboon, Thitiporn, Saipanya, Airada, Than-in-at, Kanchana, Jaisieng, Nirattiya, Suaysod, Rapeepan, Chailoet, Sanuphong, Naratee, Naritsara, Kawilapat, Suttipong, Lyall, Hermione, Bamford, Alasdair, Butler, Karim, Doherty, Conor, Foster, Caroline, Francis, Kate, Harrison, Ian, Kenny, Julia, Klein, Nigel, Letting, Gillian, McMaster, Paddy, Murau, Fungai, Nsangi, Edith, Peters, Helen, Prime, Katia, Riordan, Andrew, Shackley, Fiona, Shingadia, Delane, Storey, Sharon, Tudor-Williams, Gareth, Turkova, Anna, Welch, Steve, Collins, Intira Jeannie, Cook, Claire, Dobson, Donna, Fairbrother, Keith, Harper, Lynda, Le Prevost, Marthe, Van Looy, Nadine, Butler, K., Walsh, A., Thrasyvoulou, L., Welch, S., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Sloper, K., Fidler, K., Hague, R., Price, V, Clapson, M., Flynn, J., Abou-Rayyah, A. Cardoso M., Klein, N., Shingadia, D., Gurtin, D., Yeadon, S., Segal, S., Ball, C., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Clough, S., Anguvaa, L., Conway, S., Flood, T., Pickering, A., Murphy, P. McMaster C., Daniels, J., Lees, Y., Thompson, F., Williams, B., Pope, S., Cliffe, L., Smyth, A., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Clarke, D. Rogahn L., Jones, L., Offerman, B., Greenberg, M., Benson, C., Riordan, A., Ibberson, L., Shackley, F., Faust, S. N., Hancock, J., Doerholt, K., Prime, K., Sharland, M., Storey, S., Lyall, H., Monrose, C., Seery, P., Tudor-Williams, G., Menson, E., Callaghan, A., Bridgwood, A., McMaster, P., Evans, J., Blake, E., Yannoulias, A., European Pregnancy Paediat HIV Coh, Microbes in Health and Disease (MHD), Fundación Investigación y Educación en Sida, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est (IRD_PHPT), Harvard University [Cambridge]-Chiang Mai University (CMU), Pediatrics, and Virology

Subjects
0301 basic medicine, Male, Pediatrics, puberty, [SDV]Life Sciences [q-bio], humanos, Human immunodeficiency virus (HIV), adolescente, LETTONIE, CHILDREN, HIV Infections, medicine.disease_cause, GRECE, desarrollo del niño, Cohort Studies, 0302 clinical medicine, Child Development, CHILD_DEVELOPMENT, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, ADOLESCENTS, Immunology and Allergy, Pooled data, 030212 general & internal medicine, SUEDE, Child, estudios de cohortes, ESPAGNE, 11 Medical and Health Sciences, Anthropometry, THAILANDE, Europe, growth, height, HIV, perinatal, Thailand, Adolescent, Anti-Retroviral Agents, Child, Preschool, Female, Humans, Infant, Puberty, virus diseases, Growth spurt, PAYS BAS, 3. Good health, 17 Psychology and Cognitive Sciences, AIDS, antirretrovirales, Infectious Diseases, POLOGNE, BELGIQUE, Life Sciences & Biomedicine, medicine.medical_specialty, Pediatric hiv, Epidemiology and Social, ROYAUME UNI, Immunology, MASS, European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Virology, medicine, pubertad, Preschool, lactante, ROUMANIE, Science & Technology, business.industry, 06 Biological Sciences, VELOCITY, SUISSE, Regimen, 030104 developmental biology, VIRAL LOAD, antropometría, infecciones por VIH, BODY_HEIGHT, business, IRLANDE, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group., [Objective]: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. [Design]: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. [Methods]: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1–10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. [Results]: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and −1.2 (IQR: −2.3 to −0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20–0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21–1.78) years later in those starting with HAZ less than −3 compared with HAZ at least −1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than −1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least −1, there was no association with age. Girls and boys who initiated ART with HAZ at least −1 maintained a similar height to the WHO reference mean. [Conclusion]: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least −1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age., This work has been partially funded by the Fundación para la Investigación y Prevención de SIDA en España (FIPSE) (FIPSE 3608229/09, FIPSE 240800/09, FIPSE 361910/10), Red Temática de Investigación en SIDA (RED RIS) supported by Instituto de Salud Carlos III (ISCIII) (RD12/0017/0035 and RD12/0017/0037), project as part of the Plan R+D+I and cofinanced by ISCIII- Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER),Mutua Madrileña 2012/0077, Gilead Fellowship 2013/0071, FIS PI15/00694,CoRISpe (RED RIS RD06/0006/0035 y RD06/0006/0021).

Published
2019

13. Prognostic factors of a lower CD4/CD8 ratio in long term viral suppression HIV infected children

Author

Guillen, Sara, Prieto, Luis, Jimenez de Ory, Santiago, Isabel Gonzalez-Tome, Maria, Rojo, Pablo, Luisa Navarro, Maria, Jose Mellado, Maria, Escosa, Luis, Sainz, Talia, Francisco, Laura, Angeles Munoz-Fernandez, Maria, Tomas Ramos, Jose, Garcia Hortelano, Milagros, Blazquez, Daniel, Epalza, Cristina, Saavedra, Jesus, Santos, Mar, Angeles Munoz, Ma, Santiago, Begona, Carrasco, Itziar, Angel Roa, Miguel, Beceiro, Jose, Penin, Maria, Martinez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Gomez Sirvent, Jorge, Garzon, Monica, Roman, Vicente, Jose Munoz, Maria, Angulo, Raquel, Neth, Olaf, Falcon, Lola, Terol, Pedro, Luis Santos, Juan, Moreno, David, Lendinez, Francisco, Peromingo, Estrella, Montero, Maria, Grande, Ana, Jose Romero, Francisco, Perez, Carlos, Martinez, Maria, Lillo, Miguel, Losada, Begona, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Antonio Couceiro, Jose, Vila, Leticia, Calvino, Consuelo, Isabel Piqueras, Ana, Breton, Rafael, Oltra, Manuel, Lopez, Eva, Segarra, Inmaculada, Gavilan, Cesar, Montesinos, Elena, Dapena, Marta, Alvarez, Cristina, Jimenez, Beatriz, Gloria Andres, Ana, Marugan, Victor, Ochoa, Carlos, Alfayate, Santiago, Isabel Menasalvas, Ana, Ruiz del Prado, Yolanda, Soler-Palacin, Pere, Antoinette Frick, Maria, Mur, Antonio, Lopez, Nuria, Mendez, Maria, Mayol, Lluis, Vallmanya, Teresa, Calavia, Olga, Garcia, Lourdes, Pineda, Valenti, Rius, Neus, Duenas, Joaquin, Fortuny, Claudia, Noguera-Julian, Antoni, and CoRISpe Cohorte Nacl VIH Pediat RE

Subjects
Male, Multivariate analysis, humanos, CD4-CD8 Ratio, adolescente, HIV Infections, Pathology and Laboratory Medicine, Pediatrics, Families, Mathematical and Statistical Techniques, Antiretroviral Therapy, Highly Active, Medicine and Health Sciences, Public and Occupational Health, Viral suppression, Child, Immune Response, Children, Univariate analysis, Multidisciplinary, inmunidad, Statistics, Viral Load, Prognosis, Vaccination and Immunization, pronóstico, antirretrovirales, Anti-Retroviral Agents, Child, Preschool, Physical Sciences, Medicine, Female, carga viral, VIH-1, Pediatric Infections, Viral load, Research Article, Cart, medicine.medical_specialty, Adolescent, Science, Immunology, Antiretroviral Therapy, Research and Analysis Methods, Microbiology, Immune Suppression, Immune Activation, Immune system, Signs and Symptoms, Antiviral Therapy, Diagnostic Medicine, Internal medicine, Virology, medicine, Humans, Statistical Methods, lactante, business.industry, Immunity, Infant, Newborn, Infant, Biology and Life Sciences, Age Groups, People and Places, Multivariate Analysis, HIV-1, Population Groupings, infecciones por VIH, Preventive Medicine, business, relación CD4-CD8, CD8, Viral Transmission and Infection, Mathematics
Abstract

CoRISpe (Cohorte Nacional de VIH pediátrica de la RED RIS)., [Background] Combination antiretroviral therapy (cART) is associated with marked immune reconstitution. Although a long term viral suppression is achievable, not all children however, attain complete immunological recovery due to persistent immune activation. We use CD4/CD8 ratio like a marker of immune reconstitution., [Methods] Perinatal HIV-infected children who underwent a first-line cART, achieved viral suppression in the first year and maintained it for more than 5 years, with no viral rebound were included. Logistic models were applied to estimate the prognostic factors, clinical characteristics at cART start, of a lower CD4/CD8 ratio at the last visit., [Results] 146 HIV-infected children were included: 77% Caucasian, 45% male and 28% CDC C. Median age at cART initiation was 2.3 years (IQR: 0.5–6.2). 42 (30%) children received mono-dual therapy previously to cART. Time of undetectable viral load was 9.5 years (IQR: 7.8, 12.5). 33% of the children not achieved CD4/CD8 ratio >1. Univariate analysis showed an association between CD4/CD8, [Conclusions] CD4/CD8 >1 was not achieved in 33% of the children. Lower CD4 nadir and previous exposure to suboptimal therapy, before initiating cART, are factors showing independently association with a worse immune recovery (CD4/CD8 < 1).

Published
2019

14. Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand

Author

Fundación Investigación y Educación en Sida, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Crichton, Siobhan, Belfrage, Eric, Collins, Intira Jeanne, Doerholt, Katja, Judd, Ali, Le Coeur, Sophie, Spoulou, Vana, Goodall, Ruth, Scherpbier, Henriette, Smit, Colette, Goetghebuer, Tessa, Muñoz, Maria José, Grande, Ana, Romero, Francisco Jose, Wensing, A. M. J., Scholvinck, E. H., Mazza, Antonio, Pérez, Carlos, Jiménez de Ory, Santiago, Henriet, S. S., V, Couceiro, José, Bakker, Y., Zaaijer, H. L., de Tejada, Begona Martinez, Wolfs, T. F. W., Lillo, Miguel, Marczynska, Magdalena, Bezemer, M., Santos, Mar, de Jong, A., Losada, Begoña, Cornelissen, M. T. E., van der Meer, R., Niesters, H. G. M., El Berkaoui, A., Gavilán, César, Gloria Andres, Ana, Rius, Neus, Zaheri, S., Marugan, Victor, Neth, Olaf, Piqueras, Ana I., Ochoa, Carlos, Munjishvili, L., Schnorr, P., Breton, Rafael, Strik-Albers, R., Martínez, Jorge, Grivell, S., Delforge, Marc, Wit, F. W. M. N., Bezemer, D. O., Tuijn, E., de Martino, Maurizio, Paling, E., de Groot-de Jonge, H., Koops, J., Lipreri, Rita, Muñoz-Fernández, María Ángeles, Noguera-Julián, Antoni, Tovo, Pier Angelo, van de Sande, L., Patrizia, Osimani, Saavedra-Lozano, Jesús, Di Biagio, Antonio, Montesinos, Elena, Soler-Palacín, Pere, Berkhout, B., Meijering, R., van der Vliet, S., van Aerde, K., Antoinette Frick, Maria, Salvini, Filippo, Verduyn-Lunel, F., Tagliabue, Claudia, Geerlinks, J., Garrote, Elisa, Rovira, Nuria, Tuk, B., Bergsma, D., Pineda, Valentí, Coupland, Urszula, Tomás Ramos, José, Cellini, Monica, Dueñas, Joaquin, Pellegatta, Antonio, Bustillo Alonso, Matilde, Navarro, Maria Luisa, Pajkrt, D., Badolato, Raffaele, Terol, Pedro, Scherpbier, H. J., Garcia Hortelano, Milagros, Beceiro, Jose, Bernardi, Stefania, Weijsenfeld, A. M., Pocheville, Itziar, López, Núria, Doroba, Malgorzata, Schinkel, C. J., Ruiz, Beatriz, Wolthers, K. C., Fraaij, P. L. A., Fernandez Mc Phee, Carolina, Sainz, Talia, Zawadka, Konrad, van Rossum, A. M. C., Romano, Amelia, Fortuny, Claudia, Peeck, B., Mur, Antonio, Gibb, Diana M., Santa Ansone, Vermont, C. L., Alfayate, Santiago, Apilanez, Miren, Kruijne, E., Okhonskaia, Liubov, van der Knaap, L. C., Méndez, María José, Rojo, Pablo, van Leer-Buter, C. C., Rahamat-Langendoen, J., Angulo, Raquel, Ruggeri, Maurizio, Álvarez, Susana, Knoester, M., Back, N. K. T., Lisi, Catiuscia, Bont, L. J., Guerrero, Carmelo, Larovere, Domenico, Mellado, Maria Jose, Herranz, Mercedes, Colino, Elena, Raethke, M., Badillo, Katie, Roa, Miguel Angel, Collado, Pilar, Rutkens, T., Gonzalez-Tome, Maria I., Lo Vecchio, Andrea, Pas, S. D., Falcón Neyra, Lola, Venturini, Elisabetta, de Groot, L., Jareno, Enrique, van den Akker, M., Olmeo, Paolina, Lucas, E., Decker, Luc, Segarra, Inmaculada, Gomez Sirvent, Jorge, Perez, Amparo, Thorne, Claire, Menasalvas, Ana Isabel, Ree, C., Hillebregt, M., Regtop, R., Nauta, N., Faldella, Giacomo, Jourdain, Gonzague, Moreno-Pérez, David, Taramasso, Lucia, Álvarez, Cristina, Reiss, Peter, Ruijs, Y., Baldi, Francesco, Voronin, Evgeny, Boucher, C. A. B., Galli, Luisa, Miguel, E. de, Wisse, A., Miloenko, Milana, Giacomet, Vania, Labutina, Svetlana, Witte, E. C., Consolini, Rita, Smit, C., Hainaut, Marc, Mayol, Lluis, Rampon, Osvalda, Vallmanya, Teresa, Giaquinto, Carlo, Dona, Daniele, Erba, Paola, Dapena, Marta, Calavia, Olga, Veenenberg, L., Montagnani, Carlotta, van de Flier, M., Schuurman, R., Bruzzese, Eugenia, García, Lourdes, Geelen, S. P. M., Coll, María T., Oldakowska, Agnieszka, de Boer, C. G., Genovese, Orazio, Van der Kelen, Evelyne, Blázquez-Gamero, Daniel, Escosa-García, Luis, Jurriaans, S., Dodi, Icilio, Santos, Juan Luis, Prieto, Luís, Perez-Hoyos, Santiago, Lodewijk, C., Guillén, Sara, Koopmans, M. P. G., Ene, Luminita, Visser, E. G., Gabiano, Clara, Garzon, Monica, Kuekou, Hyppolite Tchidjou, Maccabruni, Anna, van Kampen, J. J. A., Roman, Vicente, Esposito, Susanna, Schoorl, M., Gamell, Anna, Cristiano, Letizia, Montesdeoca, Abián, Stelma, F. F., Mateo, Mercedes, Pokorska-Spiewak, Maria, van Sighem, A., I, Woudstra, T., Popielska, Jolanta, Garazzino, Silvia, Lendinez, Francisco, Fundación Investigación y Educación en Sida, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Crichton, Siobhan, Belfrage, Eric, Collins, Intira Jeanne, Doerholt, Katja, Judd, Ali, Le Coeur, Sophie, Spoulou, Vana, Goodall, Ruth, Scherpbier, Henriette, Smit, Colette, Goetghebuer, Tessa, Muñoz, Maria José, Grande, Ana, Romero, Francisco Jose, Wensing, A. M. J., Scholvinck, E. H., Mazza, Antonio, Pérez, Carlos, Jiménez de Ory, Santiago, Henriet, S. S., V, Couceiro, José, Bakker, Y., Zaaijer, H. L., de Tejada, Begona Martinez, Wolfs, T. F. W., Lillo, Miguel, Marczynska, Magdalena, Bezemer, M., Santos, Mar, de Jong, A., Losada, Begoña, Cornelissen, M. T. E., van der Meer, R., Niesters, H. G. M., El Berkaoui, A., Gavilán, César, Gloria Andres, Ana, Rius, Neus, Zaheri, S., Marugan, Victor, Neth, Olaf, Piqueras, Ana I., Ochoa, Carlos, Munjishvili, L., Schnorr, P., Breton, Rafael, Strik-Albers, R., Martínez, Jorge, Grivell, S., Delforge, Marc, Wit, F. W. M. N., Bezemer, D. O., Tuijn, E., de Martino, Maurizio, Paling, E., de Groot-de Jonge, H., Koops, J., Lipreri, Rita, Muñoz-Fernández, María Ángeles, Noguera-Julián, Antoni, Tovo, Pier Angelo, van de Sande, L., Patrizia, Osimani, Saavedra-Lozano, Jesús, Di Biagio, Antonio, Montesinos, Elena, Soler-Palacín, Pere, Berkhout, B., Meijering, R., van der Vliet, S., van Aerde, K., Antoinette Frick, Maria, Salvini, Filippo, Verduyn-Lunel, F., Tagliabue, Claudia, Geerlinks, J., Garrote, Elisa, Rovira, Nuria, Tuk, B., Bergsma, D., Pineda, Valentí, Coupland, Urszula, Tomás Ramos, José, Cellini, Monica, Dueñas, Joaquin, Pellegatta, Antonio, Bustillo Alonso, Matilde, Navarro, Maria Luisa, Pajkrt, D., Badolato, Raffaele, Terol, Pedro, Scherpbier, H. J., Garcia Hortelano, Milagros, Beceiro, Jose, Bernardi, Stefania, Weijsenfeld, A. M., Pocheville, Itziar, López, Núria, Doroba, Malgorzata, Schinkel, C. J., Ruiz, Beatriz, Wolthers, K. C., Fraaij, P. L. A., Fernandez Mc Phee, Carolina, Sainz, Talia, Zawadka, Konrad, van Rossum, A. M. C., Romano, Amelia, Fortuny, Claudia, Peeck, B., Mur, Antonio, Gibb, Diana M., Santa Ansone, Vermont, C. L., Alfayate, Santiago, Apilanez, Miren, Kruijne, E., Okhonskaia, Liubov, van der Knaap, L. C., Méndez, María José, Rojo, Pablo, van Leer-Buter, C. C., Rahamat-Langendoen, J., Angulo, Raquel, Ruggeri, Maurizio, Álvarez, Susana, Knoester, M., Back, N. K. T., Lisi, Catiuscia, Bont, L. J., Guerrero, Carmelo, Larovere, Domenico, Mellado, Maria Jose, Herranz, Mercedes, Colino, Elena, Raethke, M., Badillo, Katie, Roa, Miguel Angel, Collado, Pilar, Rutkens, T., Gonzalez-Tome, Maria I., Lo Vecchio, Andrea, Pas, S. D., Falcón Neyra, Lola, Venturini, Elisabetta, de Groot, L., Jareno, Enrique, van den Akker, M., Olmeo, Paolina, Lucas, E., Decker, Luc, Segarra, Inmaculada, Gomez Sirvent, Jorge, Perez, Amparo, Thorne, Claire, Menasalvas, Ana Isabel, Ree, C., Hillebregt, M., Regtop, R., Nauta, N., Faldella, Giacomo, Jourdain, Gonzague, Moreno-Pérez, David, Taramasso, Lucia, Álvarez, Cristina, Reiss, Peter, Ruijs, Y., Baldi, Francesco, Voronin, Evgeny, Boucher, C. A. B., Galli, Luisa, Miguel, E. de, Wisse, A., Miloenko, Milana, Giacomet, Vania, Labutina, Svetlana, Witte, E. C., Consolini, Rita, Smit, C., Hainaut, Marc, Mayol, Lluis, Rampon, Osvalda, Vallmanya, Teresa, Giaquinto, Carlo, Dona, Daniele, Erba, Paola, Dapena, Marta, Calavia, Olga, Veenenberg, L., Montagnani, Carlotta, van de Flier, M., Schuurman, R., Bruzzese, Eugenia, García, Lourdes, Geelen, S. P. M., Coll, María T., Oldakowska, Agnieszka, de Boer, C. G., Genovese, Orazio, Van der Kelen, Evelyne, Blázquez-Gamero, Daniel, Escosa-García, Luis, Jurriaans, S., Dodi, Icilio, Santos, Juan Luis, Prieto, Luís, Perez-Hoyos, Santiago, Lodewijk, C., Guillén, Sara, Koopmans, M. P. G., Ene, Luminita, Visser, E. G., Gabiano, Clara, Garzon, Monica, Kuekou, Hyppolite Tchidjou, Maccabruni, Anna, van Kampen, J. J. A., Roman, Vicente, Esposito, Susanna, Schoorl, M., Gamell, Anna, Cristiano, Letizia, Montesdeoca, Abián, Stelma, F. F., Mateo, Mercedes, Pokorska-Spiewak, Maria, van Sighem, A., I, Woudstra, T., Popielska, Jolanta, Garazzino, Silvia, and Lendinez, Francisco

Abstract

[Objective]: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. [Design]: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. [Methods]: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1–10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. [Results]: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and −1.2 (IQR: −2.3 to −0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20–0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21–1.78) years later in those starting with HAZ less than −3 compared with HAZ at least −1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than −1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least −1, there was no association with age. Girls and boys who initiated ART with HAZ at least −1 maintained a similar height to the WHO reference mean. [Conclusion]: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least −1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age.

Published
2019

15. Clinical Presentations and Outcomes Related to Tuberculosis in Children Younger Than 2 Years of Age in Catalonia

Author

Soriano-Arandes, Antoni, primary, Brugueras, Silvia, additional, Rodríguez Chitiva, Alejandro, additional, Noguera-Julian, Antoni, additional, Orcau, Àngels, additional, Martín-Nalda, Andrea, additional, Millet, Joan P., additional, Vallmanya, Teresa, additional, Méndez, Maria, additional, Coll-Sibina, Maite, additional, Mayol, Luis, additional, Clopés, Asumpció, additional, Pineda, Valentí, additional, García, Lourdes, additional, López, Nuria, additional, Calavia, Olga, additional, Rius, Neus, additional, Pérez-Porcuna, Tomas M., additional, Soler-Palacín, Pere, additional, and Caylà, Joan A., additional

Published
2019
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16. Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe

Author

European Commission, Janssen Biotech, Thorne, Claire, Turkova, Anna, Indolfi, Giuseppe, Venturini, Elisabetta, Giaquinto, Carlo, Goetghebuer, Tessa, Hainaut, Marc, Van der Kelen, Evelyne, Königs, Christoph, Mantzsch, Kathleen, Baumann, Ulrich, de Martino, Maurizio, Galli, Luisa, Giacomet, Vania, Nicolini, Laura Ambra, Del Puente, Filippo, Gabiano, Clara, Guarino, Alfredo, Martinazzi, Silvia, Miniaci, Angela, Dobsz, Sabina, Marczynska, Magdalena, Ene, Luminita, Duiculescu, Dan, Miloenko, Milana, Dodonov, Konstantin, Latysheva, Inga, Voronin, Evgeny, Rojo, Pablo, Ramos, José Tomás, Navarro Gómez, María Luisa, Jiménez de Ory, Santiago, Sainz, Talia, Mellado, Maria Jose, García, Miluca, Pérez, Carlos, Moreno-Pérez, David, Nuñez, Esmeralda, Gracia, Mercedes, Terol, Pedro, Neth, Olaf, Falcón Neyra, Lola, Otero, Carmen, Rincón, Elena, Gavilán, César, López, Carmen, Santos, Juan Luis, Couceiro, José, Noguera-Julián, Antoni, Fortuny, Claudia, Soler-Palacín, Pere, Espiau, María, Mur, Antonio, Coll, María T., Valmanya, María T., Mayol, Lluis, Méndez, María José, Rodrigo, Carlos, Escribano, Joaquín, Rius, Neus, Rovira, Núria, Calavia, Olga, García, Lourdes, Pineda, Valentí, Soriano-Arandes, Antoni, Rudin, Christoph, Duppenthaler, Andrea, Judd, Ali, Malyuta, Ruslan, Volokha, Alla, Raus, Irina, Kaleeva, T., Baryshnikova, Y., Soloha, Svetlana, Bashkatova, N., Glutshenko, O., Ruban, Z., Primak, Natalia, Kiseleva, Galina, European Commission, Janssen Biotech, Thorne, Claire, Turkova, Anna, Indolfi, Giuseppe, Venturini, Elisabetta, Giaquinto, Carlo, Goetghebuer, Tessa, Hainaut, Marc, Van der Kelen, Evelyne, Königs, Christoph, Mantzsch, Kathleen, Baumann, Ulrich, de Martino, Maurizio, Galli, Luisa, Giacomet, Vania, Nicolini, Laura Ambra, Del Puente, Filippo, Gabiano, Clara, Guarino, Alfredo, Martinazzi, Silvia, Miniaci, Angela, Dobsz, Sabina, Marczynska, Magdalena, Ene, Luminita, Duiculescu, Dan, Miloenko, Milana, Dodonov, Konstantin, Latysheva, Inga, Voronin, Evgeny, Rojo, Pablo, Ramos, José Tomás, Navarro Gómez, María Luisa, Jiménez de Ory, Santiago, Sainz, Talia, Mellado, Maria Jose, García, Miluca, Pérez, Carlos, Moreno-Pérez, David, Nuñez, Esmeralda, Gracia, Mercedes, Terol, Pedro, Neth, Olaf, Falcón Neyra, Lola, Otero, Carmen, Rincón, Elena, Gavilán, César, López, Carmen, Santos, Juan Luis, Couceiro, José, Noguera-Julián, Antoni, Fortuny, Claudia, Soler-Palacín, Pere, Espiau, María, Mur, Antonio, Coll, María T., Valmanya, María T., Mayol, Lluis, Méndez, María José, Rodrigo, Carlos, Escribano, Joaquín, Rius, Neus, Rovira, Núria, Calavia, Olga, García, Lourdes, Pineda, Valentí, Soriano-Arandes, Antoni, Rudin, Christoph, Duppenthaler, Andrea, Judd, Ali, Malyuta, Ruslan, Volokha, Alla, Raus, Irina, Kaleeva, T., Baryshnikova, Y., Soloha, Svetlana, Bashkatova, N., Glutshenko, O., Ruban, Z., Primak, Natalia, and Kiseleva, Galina

Abstract

[Objective] To characterize children, adolescents and young adults infected with HIV/hepatitis C virus (HCV) vertically or before age of 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment., [Design] Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts., [Methods] Patients aged more than 18 months and less than 25 years, with HIV/HCV acquired vertically or in childhood, were included. Anonymized individual patient data were collected using a standard protocol and modified HIV Cohorts Data Exchange Protocol., [Results] Of 229 patients included, 142 (62%) had vertically acquired infection. Median age at last follow-up was 16.2 years. Most children had HCV genotype 1 (101/184, 55%) or 3 (57/184, 31%). One-fifth (46/214) had a previous AIDS diagnosis (data missing on prior AIDS diagnoses for 15). At their last clinic visit, 70% (145/208) had no/mild immunosuppression (Centers for Disease Control and Prevention stage 1), and 131 of 179 on antiretroviral therapy had undetectable HIV RNA (assay thresholds varied from <20 to <150 copies/ml). Overall, 42% (86/204) had hepatomegaly in the previous year, and 55% (116/213) had alanine aminotransferase more than 40 IU/l at their last test. Of 97 patients with transient elastography, 12 had results more than 9 kPa; this was associated with duration of HCV infection (P = 0.033), but not with CD4+ cell count, antiretroviral therapy use or sex in univariable analysis. Of 17 patients with liver biopsies, six had bridging fibrosis and one had cirrhosis. Twenty-five (11%) had been treated successfully for HCV., [Conclusion] The high proportion of patients with progressive liver disease underscores the need for close monitoring and earlier and more effective HCV treatment.

Published
2017

17. Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

Author

Colino, Elena, Gómez-Pastrana, David, Montero, Maria, Peromingo, Estrella, Bustillo, Matilde, Moliner, Elisenda, Fenoy, Marina, Velásquez, Marta, Soler, Maria Queralt, GARCÍA, Lourdes, Calavia, Olga, Rius, Neus, Pascual, Maria Teresa, Soler-Palacín, Pere, Tórtola, Teresa, Lillo, Miguel, Dapena, Marta, López-Medina, Eva María, Ruiz, Marta, Santos, Maria del Mar, Hernández, Ángel, Hernández-Sanpelayo, Teresa, Tagarro, Alfredo, Méndez, Ana, Mellado, María José, Baquero-Artigao, Fernando, Sainz, Talía, García-Hortelano, Miluca, Álvarez, Javier, Villalobos, Enrique, García-García, María Luz, Garrote, María Isabel, Korta Murua, José Javier, Gundín, Nerea Azurmendi, Sánchez-Torrent, Laia, Velasco-Arnaiz, Eneritz, Fortuny, Clàudia, Soler-Garcia, Aleix, Gamell, Anna, Santiago, Begoña, Monsonís, Manuel, Calvo, Cristina, Cobo, Elvira, Espiau, María, Guerrero-Laleona, Carmelo, Lobato, Zulema, Martín-Nalda, Andrea, Pérez-Gorricho, Beatriz, Perez-Porcuna, Tomas M., Piqueras, Ana Isabel, Rodríguez-Molino, Paula, Soriano-Arandes, Antoni, Valmanya, Teresa, Tebruegge, Marc, and Noguera-Julian, Antoni

Published
2020
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18. Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children.

Author

Martínez-Planas, Aina, Baquero-Artigao, Fernando, Santiago, Begoña, Fortuny, Clàudia, Méndez-Echevarría, Ana, Del Rosal, Teresa, Bustillo-Alonso, Matilde, Gale, Inés, Guerrero, Carmelo, Blázquez-Gamero, Daniel, Canet, Anna, Lillo, Miguel, Calavia, Olga, Núñez Cuadros, Esmeralda, Falcón-Neyra, Lola, Soriano-Arandes, Antoni, Van Ingen, Jakko, Tebruegge, Marc, Noguera-Julian, Antoni, and Spanish Pediatric TB Research Network (pTBred) and the European NontuberculouS MycoBacterial Lymphadenitis in childrEn study

Abstract

Objectives: To assess the performance of interferon-gamma release assays (IGRAs) in the differential diagnosis between Mycobacterium avium complex (MAC) and tuberculosis (TB) in children affected with subacute/chronic submandibular/cervical lymphadenitis.Study Design: Multicenter observational study comparing children with microbiologically confirmed MAC lymphadenitis from the European NontuberculouS MycoBacterial Lymphadenitis in childrEn study with children with TB lymphadenitis from the Spanish Network for the Study of Pediatric TB database.Results: Overall, 78 patients with MAC and 34 with TB lymphadenitis were included. Among MAC cases, 44 out of 74 (59.5%) had positive tuberculin skin test (TST) results at the 5-mm cut-off, compared with 32 out of 33 (97%) TB cases (P < .001); at the 10-mm cut-off TST results were positive in 23 out of 74 (31.1%) vs 26 out of 31 (83.9%), respectively (P < .001). IGRA results were positive in only 1 out of 32 (3.1%) patients with MAC who had undergone IGRA testing, compared with 21 out of 23 (91.3%) TB cases (P < .001). Agreement between TST and IGRA results was poor in MAC (23.3%; κ = 0.017), but good in TB cases (95.6%; κ = 0.646). IGRAs had a specificity of 96.9% (95% CI 84.3%-99.8%), positive predictive value of 95.4% (95% CI 78.2%-99.8%), and negative predictive value of 93.9% (95% CI 80.4%-98.9%) for TB lymphadenitis.Conclusions: In contrast to TST, IGRAs have high specificity, negative predictive value, and positive predictive value for TB lymphadenitis in children with subacute/chronic lymphadenopathy, and consequently can help to discriminate between TB and MAC disease. Therefore, IGRAs are useful tools in the diagnostic work-up of children with lymphadenopathy, particularly when culture and polymerase chain reaction results are negative. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Impact of immigration on HIV mother-to-child transmission in Western Europe.

Author

Soriano‐Arandes, A, Noguera‐Julian, A, Fortuny, C, Soler‐Palacín, Pere, Frick, Antoinette, Mur, Antonio, Méndez, María, Rodrigo, Carlos, Mayol, Lluís, Vallmanya, Teresa, Calavia, Olga, García, Lourdes, Coll, Maite, Pineda, Valentí, Rius, Neus, Rovira, Núria, Casabona, Jordi, and Carnicer‐Pont, Dolors

Subjects
HIV prevention, ANTIRETROVIRAL agents, VERTICAL transmission (Communicable diseases), CONFIDENCE intervals, EMIGRATION & immigration, HEALTH services accessibility, HEALTH status indicators, LONGITUDINAL method, DATA analysis software, DESCRIPTIVE statistics, FETUS, PREGNANCY, DISEASE risk factors
Abstract

The article focuses on the effects of immigration on the epidemiology of HIV transmission from mother to child in Western Europe. It discusses the Spanish NENEXP cohort study of mother to child HIV transmission in Catalonia, Spain, antiretroviral therapy (ART), and the effects of good antenatal care services.

Published
2017
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