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Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [(18)F], was synthesised in radiofluorinated form. PET/CT Imaging with [(18)F] identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

1-(2-Pyridyl)-2-propen-1-ol, obtained by vinylation of commercially available picolinaldehyde, resulted a good starting material for the synthesis of the indolizidine skeleton. In particular, a simple process involving bromination, reduction, and nucleophilic substitution (via elimination and addition) allowed an easy conversion of the starting material into (±)-lentiginosine in ~27% overall yield.

The bactericidal subcellular granules of rat peritoneal neutrophils were studied to determine selected physical and biochemical characteristics. Isopycnic centrifugation of these granules resolved them into three subpopulations: specific granules (buoyant density = 1.176) as well as light and heavy azurophil granules (buoyant density = 1.20 and 1.22, respectively). These buoyant densities corresponded closely to those of similarly isolated human granules. Specific granules of rat peritoneal neutrophil contained 68 per cent of the sedimentable alkaline phosphatase activity and part of the lysozyme of the whole rat peritoneal neutrophil. The light azurophil granules contained the remainder of the lysozyme, as well as a substantial portion of the beta-glucuronidase activity. Peroxidase was detected in both light and heavy azurophil granules, as was neutral protease. Morphologically, the rat specific granules were round or slightly ovoid organelles (0.10 to 0.13 micrometer in diameter). The azurophil granules were larger (0.3 micrometer) ellipsoid as well as round in shape, and stained strongly for peroxidase. These granules were significantly smaller than the crystal-containing granules of eosinophils.