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735 results on '"Calado, Rodrigo T."'

2. Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil

Author

Donadel, Camila D., De Santis, Gil C., Gonçalves, Thiago E., Pires, Bruno G., Palma, Leonardo C., Gava, Flavia, Guerino-Cunha, Renato Luiz, Faria, Joana T. B., Silva, Gabriela V. A., Darrigo-Junior, Luiz Guilherme, Fatobene, Giancarlo, Rocha, Vanderson, Covas, Dimas T., Calado, Rodrigo T., and Clé, Diego V.

Published
2024
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4. The recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells

Author

Costa, Mariana do Nascimento, Silva, Thiago Aparecido, Guimarães, Dimitrius Santiago Passos Simões Fróes, Ricci-Azevedo, Rafael, Teixeira, Felipe Roberti, Silveira, Leonardo Reis, Gomes, Marcelo Damário, Faça, Vítor Marcel, de Oliveira, Eduardo Brandt, Calado, Rodrigo T., and Silva, Roberto N.

Published
2024
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5. Telomeres

Author

Donaires, Flavia S., Calado, Rodrigo T., and Bueno, Valquiria, editor

Published
2024
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6. SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients

Author

Pontelli, Marjorie C, Castro, Ítalo A, Martins, Ronaldo B, La Serra, Leonardo, Veras, Flávio P, Nascimento, Daniele C, Silva, Camila M, Cardoso, Ricardo S, Rosales, Roberta, Gomes, Rogério, Lima, Thais M, Souza, Juliano P, Vitti, Brenda C, Caetité, Diego B, de Lima, Mikhael HF, Stumpf, Spencer D, Thompson, Cassandra E, Bloyet, Louis-Marie, Toller-Kawahisa, Juliana E, Giannini, Marcela C, Bonjorno, Letícia P, Lopes, Maria IF, Batah, Sabrina S, Siyuan, Li, Luppino-Assad, Rodrigo, Almeida, Sergio CL, Oliveira, Fabiola R, Benatti, Maíra N, Pontes, Lorena LF, Santana, Rodrigo C, Vilar, Fernando C, Auxiliadora-Martins, Maria, Shi, Pei-Yong, Cunha, Thiago M, Calado, Rodrigo T, Alves-Filho, José C, Zamboni, Dario S, Fabro, Alexandre T, Louzada-Junior, Paulo, Oliveira, Rene DR, Whelan, Sean PJ, Cunha, Fernando Q, and Arruda, Eurico

Abstract

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both signature and prognosis of disease severity outcome. Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion, it is still unclear whether direct SARS-CoV-2 infection of immune cells could also play a role in this scenario by harboring viral replication. We found that monocytes, as well as both B and T lymphocytes, were susceptible to SARS-CoV-2 infection in vitro, accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis. In addition, flow cytometry and immunofluorescence analysis revealed that SARS-CoV-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019 (COVID-19) patients. The rates of SARS-CoV-2-infected monocytes in peripheral blood mononuclear cells from COVID-19 patients increased over time from symptom onset, with SARS-CoV-2-positive monocytes, B cells, and CD4+ T lymphocytes also detected in postmortem lung tissue. These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in COVID-19 patients might have important implications for disease pathogenesis and progression, immune dysfunction, and virus spread within the host.

Published
2022

8. Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutations

Author

Gutierrez-Rodrigues, Fernanda, Groarke, Emma M., Thongon, Natthakan, Rodriguez-Sevilla, Juan Jose, Catto, Luiz Fernando B., Niewisch, Marena R., Shalhoub, Ruba, McReynolds, Lisa J., Clé, Diego V., Patel, Bhavisha A., Ma, Xiaoyang, Hironaka, Dalton, Donaires, Flávia S., Spitofsky, Nina, Santana, Barbara A., Lai, Tsung-Po, Alemu, Lemlem, Kajigaya, Sachiko, Darden, Ivana, Zhou, Weiyin, Browne, Paul V., Paul, Subrata, Lack, Justin, Young, David J., DiNardo, Courtney D., Aviv, Abraham, Ma, Feiyang, De Oliveira, Michel Michels, de Azambuja, Ana Paula, Dunbar, Cynthia E., Olszewska, Malgorzata, Olivier, Emmanuel, Papapetrou, Eirini P., Giri, Neelam, Alter, Blanche P., Bonfim, Carmem, Wu, Colin O., Garcia-Manero, Guillermo, Savage, Sharon A., Young, Neal S., Colla, Simona, and Calado, Rodrigo T.

Published
2024
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10. Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT

Author

Gurnari, Carmelo, Robin, Marie, Godley, Lucy A, Drozd-Sokołowska, Joanna, Włodarski, Marcin W, Raj, Kavita, Onida, Francesco, Worel, Nina, Ciceri, Fabio, Carbacioglu, Selim, Kenyon, Michelle, Aljurf, Mahmoud, Bonfim, Carmem, Makishima, Hideki, Niemeyer, Charlotte, Fenaux, Pierre, Zebisch, Armin, Hamad, Nada, Chalandon, Yves, Hellström-Lindberg, Eva, Voso, Maria Teresa, Mecucci, Cristina, Duarte, Fernando Barroso, Sebert, Marie, Sicre de Fontbrune, Flore, Soulier, Jean, Shimamura, Akiko, Lindsley, R Coleman, Maciejewski, Jarosław P, Calado, Rodrigo T, Yakoub-Agha, Ibrahim, and McLornan, Donal P

Published
2023
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11. Telomeric repeat-containing RNA is dysregulated in acute myeloid leukemia

Author

Catto, Luiz Fernando B., Zanelatto, Leonardo C., Donaires, Flavia S., de Carvalho, Vinicius S., Santana, Bárbara A., Pinto, André L., Fantacini, Daianne, de Souza, Lucas Eduardo B., Fonseca, Natasha P., Telho, Bruno S., Ayrosa Madeira, Maria Isabel, Barbosa Pagnano, Katia Borgia, Firmato, Ana Beatriz, Fagundes, Evandro Maranhão, Higashi, Marcia, Nunes, Elenaide Coutinho, Traina, Fabiola, Lobo de F. Pontes, Lorena, Rego, Eduardo M., and Calado, Rodrigo T.

Published
2023
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13. Spectrum of clonal hematopoiesis in VEXAS syndrome

Author

Gutierrez-Rodrigues, Fernanda, Kusne, Yael, Fernandez, Jenna, Lasho, Terra, Shalhoub, Ruba, Ma, Xiaoyang, Alessi, Hugh, Finke, Christy, Koster, Matthew J., Mangaonkar, Abhishek, Warrington, Kenneth J., Begna, Kebede, Xie, Zhuoer, Ombrello, Amanda K., Viswanatha, David, Ferrada, Marcela, Wilson, Lorena, Go, Ronald, Kourelis, Taxiarchis, Reichard, Kaaren, Olteanu, Horatiu, Darden, Ivana, Hironaka, Dalton, Alemu, Lemlem, Kajigaya, Sachiko, Rosenzweig, Sofia, Calado, Rodrigo T., Groarke, Emma M., Kastner, Daniel L., Calvo, Katherine R., Wu, Colin O., Grayson, Peter C., Young, Neal S., Beck, David B., Patel, Bhavisha A., and Patnaik, Mrinal M.

Published
2023
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14. Differential diagnosis of bone marrow failure syndromes guided by machine learning

Author

Gutierrez-Rodrigues, Fernanda, Munger, Eric, Ma, Xiaoyang, Groarke, Emma M., Tang, Youbao, Patel, Bhavisha A., Catto, Luiz Fernando B., Clé, Diego V., Niewisch, Marena R., Alves-Paiva, Raquel M., Donaires, Flávia S., Pinto, André Luiz, Borges, Gustavo, Santana, Barbara A., McReynolds, Lisa J., Giri, Neelam, Altintas, Burak, Fan, Xing, Shalhoub, Ruba, Siwy, Christopher M., Diamond, Carrie, Raffo, Diego Quinones, Craft, Kathleen, Kajigaya, Sachiko, Summers, Ronald M., Liu, Paul, Cunningham, Lea, Hickstein, Dennis D., Dunbar, Cynthia E., Pasquini, Ricardo, De Oliveira, Michel Michels, Velloso, Elvira D. R. P., Alter, Blanche P., Savage, Sharon A., Bonfim, Carmem, Wu, Colin O., Calado, Rodrigo T., and Young, Neal S.

Published
2023
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15. High-Dose Convalescent Plasma for Treatment of Severe COVID-19

Author

De Santis, Gil C., Oliveira, Luciana Correa, Garibaldi, Pedro M.M., Almado, Carlos E.L., Croda, Julio, Arcanjo, Ghislaine G.A., Oliveira, Erika A.F., Tonacio, Adriana C., Langhi, Dante M., Jr., Bordin, Jose O., Gilio, Renato N., Palma, Leonardo C., Santos, Elaine V., Haddad, Simone K., Prado, Benedito P.A., Jr., Pontelli, Marjorie Cornejo, Gomes, Rogerio, Miranda, Carlos H., Martins, Maria Auxiliadora, Covas, Dimas T., Arruda, Eurico, Fonseca, Benedito A.L., and Calado, Rodrigo T.

Subjects
Health
Abstract

Clinical signs and symptoms of coronavirus disease (COVID-19) are pleomorphic, varying from none (asymptomatic) to life-threatening. Typical signs/ symptoms are fever, dry cough, dyspnea, fatigue, myalgia, anosmia, and ageusia (1). [...]

Published
2022
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17. Treatment of severe COVID-19 patients with either low- or high-volume of convalescent plasma versus standard of care: A multicenter Bayesian randomized open-label clinical trial (COOP-COVID-19-MCTI)

Author

Song, Alice T.W., Rocha, Vanderson, Mendrone-Júnior, Alfredo, Calado, Rodrigo T., De Santis, Gil C., Benites, Bruno D., Costa-Lima, Carolina, Vargas, Taiani, Marques, Leonardo S., Fernandes, Juliana C., Breda, Felipe C., Wendel, Silvano, Fachini, Roberta, Rizzo, Luiz V., Kutner, José Mauro, Avelino-Silva, Vivian I., Machado, Rafael R.G., Durigon, Edison L., Chevret, Sylvie, and Kallas, Esper G.

Published
2022
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19. Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response.

Author

Santos, Patrick, Rezende, Caroline P., Piraine, Renan, Oliveira, Bianca, Ferreira, Francielle B., Carvalho, Vinicius S., Calado, Rodrigo T., Pellegrini, Matteo, and Almeida, Fausto

Subjects
DRUG resistance, CELL analysis, CANCER cells, MEMBRANE transport proteins, EXTRACELLULAR vesicles
Abstract

Introduction: Breast cancer is a significant public health problem around the world, ranking first in deaths due to cancer in females. The therapy to fight breast cancer involves different methods, including conventional chemotherapy. However, the acquired resistance that tumors develop during the treatment is still a central cause of cancer-associated deaths. One mechanism that induces drug resistance is cell communication via extracellular vesicles (EVs), which can carry efflux transporters and miRNA that increase sensitive cells' survivability to chemotherapy. Methods: Our study investigates the transcription changes modulated by EVs from tamoxifen- and doxorubicin-resistant breast cancer cells in sensitive cells and how these changes may induce acquired drug resistance, inhibit apoptosis, and increase survivability in the sensitive cells. Additionally, we exposed human macrophages to resistant EVs to understand the influence of EVs on immune responses. Results: Our results suggest that the acquired drug resistance is associated with the ability of resistant EVs to upregulate several transporter classes, which are directly related to the increase of cell viability and survival of sensitive cells exposed to EVs before a low-dose drug treatment. In addition, we show evidence that resistant EVs may downregulate immune system factors to evade detection and block cell death by apoptosis in sensitive breast cancer cells. Our data also reveals that human macrophages in contact with resistant EVs trigger a proinflammatory cytokine secretion profile, an effect that may be helpful for future immunotherapy studies. Discussion: These findings are the first transcriptome-wide analysis of cells exposed to resistant EVs, supporting that resistant EVs are associated with the acquired drug resistance process during chemotherapy by modulating different aspects of sensitive cancer cells that coffer the chemoresistance. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Liver disease and transplantation in telomere biology disorders: An international multicenter cohort.

Author

Wang, YunZu Michele, Kaj-Carbaidwala, Batul, Lane, Adam, Agarwal, Suneet, Beier, Fabian, Bertuch, Alison, Borovsky, Kristin A., Brennan, Steven K., Calado, Rodrigo T., Catto, Luiz Fernando B., Dufour, Carlo, Ebens, Christen L., Fioredda, Francesca, Giri, Neelam, Gloude, Nicholas, Goldman, Frederick, Hertel, Paula M., Himes, Ryan, Keel, Sioban B., and Koura, Divya T.

Published
2024
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23. Monoclonal gammopathy‐associated peripheral neuropathies: Uncovering pearls and challenges.

Author

Gonçalves, Trajano Aguiar Pires, Donadel, Camila Derminio, Frezatti, Rodrigo Siqueira Soares, Garibaldi, Pedro Manoel Marques, Calado, Rodrigo T., Marques Junior, Wilson, and Tomaselli, Pedro José

Subjects
PERIPHERAL neuropathy, PARAPROTEINEMIA, RISK assessment, DIFFERENTIAL diagnosis, NEUROPHYSIOLOGY, DISEASE risk factors, DISEASE complications, SYMPTOMS
Abstract

Monoclonal gammopathy‐related peripheral neuropathies encompass a spectrum of clinical presentations in which the monoclonal protein directly damages the tissues, including the peripheral nervous system. Given the prevalence of both peripheral neuropathy and monoclonal gammopathy in the general population, these conditions may overlap in clinical practice, posing a challenge for clinicians in determining causality. Therefore, a comprehensive understanding of primary clinical syndromes and their neurophysiological patterns is of great importance for accurate differential diagnoses and effective treatment strategies. In this article, we examine the main forms of monoclonal gammopathies that affect the peripheral nerve. We explore the clinical and electrophysiological aspects and their correlation with each syndrome's corresponding monoclonal protein type. This knowledge is essential for healthcare professionals to diagnose better and manage patients presenting with monoclonal gammopathy‐related peripheral nervous system involvement. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

Author

Mastellos, Dimitrios C., Pires da Silva, Bruno G.P., Fonseca, Benedito A.L., Fonseca, Natasha P., Auxiliadora-Martins, Maria, Mastaglio, Sara, Ruggeri, Annalisa, Sironi, Marina, Radermacher, Peter, Chrysanthopoulou, Akrivi, Skendros, Panagiotis, Ritis, Konstantinos, Manfra, Ilenia, Iacobelli, Simona, Huber-Lang, Markus, Nilsson, Bo, Yancopoulou, Despina, Connolly, E. Sander, Garlanda, Cecilia, Ciceri, Fabio, Risitano, Antonio M., Calado, Rodrigo T., and Lambris, John D.

Published
2020
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31. No Impact of Lentiviral Transduction on Hematopoietic Stem/Progenitor Cell Telomere Length or Gene Expression in the Rhesus Macaque Model

Author

Sellers, Stephanie E, Dumitriu, Bogdan, Morgan, Mary J, Hughes, William M, Wu, Colin O, Raghavarchari, Nalini, Yang, Yanqin, Uchida, Naoya, Tisdale, John F, An, Dong S, Chen, Irvin S, Hematti, Peiman, Donahue, Robert E, LaRochelle, Andre, Young, Neal S, Calado, Rodrigo T, and Dunbar, Cynthia E

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Regenerative Medicine, Biotechnology, Hematology, Stem Cell Research - Nonembryonic - Human, Stem Cell Research - Nonembryonic - Non-Human, Transplantation, Rare Diseases, Stem Cell Research, Gene Therapy, Genetics, Animals, Antigens, CD34, Gene Expression, Genetic Vectors, Green Fluorescent Proteins, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Lentivirus, Leukocytes, Mononuclear, Macaca mulatta, Telomere, Transcriptome, Transduction, Genetic, Transgenes, Biological Sciences, Technology, Medical and Health Sciences, Clinical sciences, Medical biotechnology
Abstract

The occurrence of clonal perturbations and leukemia in patients transplanted with gamma-retroviral (RV) vector-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions may perturb adjacent proto-oncogene expression. Although enhancer-deleted lentiviruses are less likely to result in insertional oncogenesis, there is evidence that they may perturb transcript splicing, and one patient with a benign clonal expansion of lentivirally transduced HPSC has been reported. The rhesus macaque model provides an opportunity for informative long-term analysis to ask whether transduction impacts on long-term HSPC properties. We used two techniques to examine whether lentivirally transduced HSPCs from eight rhesus macaques transplanted 1-13.5 years previously are perturbed at a population level, comparing telomere length as a measure of replicative history and gene expression profile of vector positive versus vector negative cells. There were no differences in telomere lengths between sorted GFP+ and GFP- blood cells, suggesting that lentiviral (LV) transduction did not globally disrupt replicative patterns. Bone marrow GFP+ and GF- CD34+ cells showed no differences in gene expression using unsupervised and principal component analysis. These studies did not uncover any global long-term perturbation of proliferation, differentiation, or other important functional parameters of transduced HSPCs in the rhesus macaque model.

Published
2014

33. Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu’s arteritis, ANCA-associated vasculitis and giant cell arteritis

Author

Gutierrez-Rodrigues, Fernanda, primary, Wells, Kristina V, additional, Jones, Adrianna I, additional, Hironaka, Dalton, additional, Rankin, Cameron, additional, Gadina, Massimo, additional, Sikora, Keith A, additional, Alemu, Lemlem, additional, Calado, Rodrigo T, additional, Quinn, Kaitlin A, additional, Patel, Bhavisha, additional, Young, Neal S, additional, and Grayson, Peter C, additional

Published
2023
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34. TERRA (telomeric repeat-containing RNA) is dysregulated in acute myeloid leukemia

Author

Catto, Luiz Fernando B., primary, Zanelatto, Leonardo C., additional, Donaires, Flavia, additional, Carvalho, Vinicius S., additional, Santana, Barbara A., additional, Pinto, André Luiz, additional, Carvalho Fantacini, Daianne Maciely, additional, Souza, Lucas E. B., additional, Fonseca, Natasha P., additional, Telho, Bruno S., additional, Madeira, Maria Isabel Ayrosa, additional, Pagnano, Katia B.B., additional, Gloria, Ana Beatriz, additional, Fagundes, Evandro M., additional, Higashi, Marcia, additional, Nunes, Elenaide C., additional, Traina, Fabiola, additional, de Figueiredo-Pontes, Lorena Lobo, additional, Rego, Eduardo M., additional, and Calado, Rodrigo T., additional

Published
2023
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35. Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

Author

Silvestre, Renata Nacasaki, primary, Eitler, Jiri, additional, de Azevedo, Julia Teixeira Cottas, additional, Tirapelle, Mariane Cariati, additional, Fantacini, Daianne Maciely Carvalho, additional, de Souza, Lucas Eduardo Botelho, additional, Swiech, Kamilla, additional, Covas, Dimas Tadeu, additional, Calado, Rodrigo T., additional, Montero, Paola Ortiz, additional, Malmegrim, Kelen Cristina Ribeiro, additional, Figueiredo, Marxa L., additional, Tonn, Torsten, additional, and Picanço-Castro, Virginia, additional

Published
2023
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36. AML-469 Ivosidenib + Azacitidine vs Placebo + Azacitidine in Patients With Newly-Diagnosed Acute Myeloid Leukemia: Updated Long-term Efficacy and Safety Results From the AGILE Study

Author

de Botton, Stéphane, primary, Montesinos, Pau, additional, Polo, Susana Vives, additional, Zarzycka, Ewa, additional, Wang, Jianxiang, additional, Riva, Marta, additional, Heuser, Michael, additional, Calado, Rodrigo T., additional, Schuh, Andre C., additional, Yeh, Su-Peng, additional, Hui, Jianan, additional, Gianolio, Diego A., additional, Patel, Prapti, additional, Recher, Christian, additional, and Döhner, Hartmut, additional

Published
2023
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37. POSTER: AML-469 Ivosidenib + Azacitidine vs Placebo + Azacitidine in Patients With Newly-Diagnosed Acute Myeloid Leukemia: Updated Long-term Efficacy and Safety Results From the AGILE Study

Author

de Botton, Stéphane, primary, Montesinos, Pau, additional, Polo, Susana Vives, additional, Zarzycka, Ewa, additional, Wang, Jianxiang, additional, Riva, Marta, additional, Heuser, Michael, additional, Calado, Rodrigo T., additional, Schuh, Andre C., additional, Yeh, Su-Peng, additional, Hui, Jianan, additional, Gianolio, Diego A., additional, Patel, Prapti, additional, Recher, Christian, additional, and Döhner, Hartmut, additional

Published
2023
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38. AML-295 AGILE: A Global, Randomized, Double-Blind, Phase 3 Study of Ivosidenib + Azacitidine Versus Placebo + Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia With an IDH1 Mutation

Author

Dohner, Hartmut, Montesinos, Pau, Polo, Susana Vives, Zarzycka, Ewa, Wang, Jianxiang, Bertani, Giambattista, Heuser, Michael, Calado, Rodrigo T., Schuh, Andre C., Yeh, Su-Peng, de la Fuente, Adolfo, Cerchione, Claudio, Daigle, Scott R., Hui, Jianan, Pandya, Shuchi S., Gianolio, Diego A., Recher, Christian, and de Botton, Stephane

Published
2022
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39. Pathogenic TERT promoter variants in telomere diseases

Author

Gutierrez-Rodrigues, Fernanda, Donaires, Flávia S., Pinto, André, Vicente, Alana, Dillon, Laura W., Clé, Diego V., Santana, Barbara A., Pirooznia, Mehdi, Ibanez, Maria del Pilar F., Townsley, Danielle M., Kajigaya, Sachiko, Hourigan, Christopher S., Cooper, James N., Calado, Rodrigo T., and Young, Neal S.

Published
2019
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41. BRAF, TERT and HLA-G Status in the Papillary Thyroid Carcinoma: A Clinicopathological Association Study

Author

Bertol, Bruna C., primary, Massaro, Juliana D., additional, Debortoli, Guilherme, additional, Santos, André L. P., additional, de Araújo, Jéssica N. G., additional, Giorgenon, Tatiana M. V., additional, Costa e Silva, Matheus, additional, de Figueiredo-Feitosa, Nathalie L., additional, Collares, Cristhianna V. A., additional, de Freitas, Luiz Carlos C., additional, Soares, Edson G., additional, Neder, Luciano, additional, Silbiger, Vivian N., additional, Calado, Rodrigo T., additional, Maciel, Léa M. Z., additional, and Donadi, Eduardo A., additional

Published
2023
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42. The recombinant L-Lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34+ hematopoietic cells

Author

Costa, Nascimento, primary, Silva, Thiago Aparecido, additional, Guimarães, Dimitrius Simões Fróes, additional, Ricci-Azevedo, Rafael, additional, Teixeira, Felipe Roberti, additional, Silveira, Leonardo Reis, additional, Gomes, Marcelo Damário, additional, Faça, Vítor Marcel, additional, Oliveira, Eduardo Brandt, additional, Calado, Rodrigo T., additional, and Silva, Roberto N., additional

Published
2023
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44. Rabbit antithymocyte globulin dose does not affect response or survival as first-line therapy for acquired aplastic anemia: a multicenter retrospective study

Author

Clé, Diego V., Atta, Elias H., Dias, Danielle S. P., Lima, Carlos B. L., Bonduel, Mariana, Sciuccati, Gabriela, Medeiros, Larissa A., de Oliveira, Michel M., Blum Fonseca, Patricia B., Saad, Sara T. O., Hamerschlak, Nelson, Salvino, Marco A., Garanito, Marlene P., Pazin-Filho, Antonio, Scheinberg, Phillip, and Calado, Rodrigo T.

Published
2018
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45. IPSS-M in myelodysplastic neoplasms arising from aplastic anemia and paroxysmal nocturnal hemoglobinuria

Author

Gurnari, Carmelo, primary, Prata, Pedro Henrique, additional, Catto, Luiz Fernando B., additional, Durmaz, Arda, additional, Larcher, Lise, additional, Sébert, Marie, additional, Allain, Vincent, additional, Kewan, Tariq, additional, Pagliuca, Simona, additional, Pinto, André Luiz, additional, B. Inacio, Mariana C., additional, Hernandez, Lucie, additional, Dhedin, Nathalie, additional, Caillat-Zucman, Sophie, additional, Clappier, Emmanuelle, additional, Sicre de Fontbrune, Flore, additional, Voso, Maria Teresa, additional, Visconte, Valeria, additional, Peffault de Latour, Régis, additional, Soulier, Jean, additional, Socie, Gérard, additional, Calado, Rodrigo T., additional, and Maciejewski, Jaroslaw P., additional

Published
2023
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49. Hematopoietic cell transplantation for telomere biology diseases: A retrospective single‐center cohort study.

Author

Nichele, Samantha, Bonfim, Carmem, Junior, Luiz G. D., Loth, Gisele, Kuwahara, Cilmara, Trennephol, Joanna, Funke, Vaneuza A. M., Marinho, Daniela E., Koliski, Adriana, Rodrigues, Adriana M., Mousquer, Rebeca T. G., Fasth, Anders, Lima, Alberto C. M., Calado, Rodrigo T., and Pasquini, Ricardo

Subjects
HEMATOPOIETIC stem cell transplantation, TELOMERES, HEMATOPOIETIC stem cells, BIOLOGY, COHORT analysis
Abstract

Background: Telomere biology diseases (TBD) result from defective telomere maintenance, leading to bone marrow failure. The only curative treatment for aplastic anemia related to TBD is a hematopoietic cell transplant (HCT). Although reduced‐intensity conditioning (RIC) regimens decrease transplant‐related mortality, non‐hematological phenotypes represent a major challenge and are associated with poor long‐term follow‐up outcomes. Objective: To describe the outcome of TBD patients transplanted for marrow failure. Study Design: This is a retrospective, single‐center study describing the outcomes of 32 consecutive transplants on 29 patients between 1993 and 2019. Results: The median age at transplantation was 14 years (range, 3–30 years). Most patients received a RIC regimen (n = 28) and bone marrow (BM) from an unrelated donor (n = 16). Four patients received a haploidentical transplant. Chimerism was available for 27 patients with a median time to neutrophil recovery of 20 days (13–36 days). Primary graft failure occurred in one patient, whereas second graft failure occurred in two. Acute GVHD grade II‐IV and moderate to severe chronic GVHD occurred in 22% of patients at risk. Fourteen patients were alive after HCT at the last follow‐up (median, 6 years; 1.4–19 years). The 5‐year overall survival was better after matched sibling donor (MSD) transplantation compared to other hematopoietic stem cell sources (88.9% vs. 47.7%; p =.05; CI = 95%). Overall, 15 patients died after HCT, most of them (n = 11) after the first year of transplant, due to non‐hematological disease progression or complication of chronic GVHD. Conclusions: Hematopoietic cell transplantation is a potentially curative treatment option for TBD, nonetheless the poor outcome reflects the progression of non‐hematologic disease manifestations, which should be considered when transplantation is indicated. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Efficacy of dupilumab for the treatment of severe skin disease in cytotoxic T lymphocyte antigen-4 insufficiency: A role of type 2 inflammation?

Author

Arruda, L. Karla, primary, Cordeiro, Daniel L., additional, Langer, Sarah S., additional, Koenigham-Santos, Marcel, additional, Calado, Rodrigo T., additional, Dias, Marina M., additional, Anhesini, Leonardo R., additional, Oliveira, João Bosco, additional, Grimbacher, Bodo, additional, and Ferriani, Mariana P.L., additional

Published
2023
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