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13 results on '"Calabria, Hug Cuéllar"'

1. Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial

Author

Mancone, Massimo, Mézquita, Aldo J. Vázquez, Birtolo, Lucia Ilaria, Maurovich-Horvat, Pal, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodriguez-Palomares, Jose, Erglis, Andrejs, Štěchovský, Cyril, Šakalytė, Gintare, Ađić, Nada Čemerlić, Gutberlet, Matthias, Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhanni, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jaqueline, Merkely, Bela, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtěch, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Keane, Stephen, Lecumberri, Ignacio, Thwaite, Erica, Kruk, Mariusz, Jovanovic, Vladimir, Kuśmierz, Donata, Feuchtner, Gudren, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Palmisano, Vitanio, Fisher, Michael, Drobni, Zsófia D., Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, del Blanco, Bruno Garcia, Rubio, Ainhoa, Boussoussou, Melinda, Hove, Jens D., Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Becker, Dávid, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Douglas, Pamela S., Estrella, Melanie, Bosserdt, Maria, Martus, Peter, Serna-Higuita, Lina M., Dodd, Jonathan D., and Dewey, Marc

Published
2024
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2. Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain

Author

Biavati, Federico, Saba, Luca, Boussoussou, Melinda, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodríguez-Palomares, José, Erglis, Andrejs, Štěchovský, Cyril, Šakalytė, Gintarė, Ađić, Nada Čemerlić, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jacqueline, Maurovich-Horvat, Pál, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtěch, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Cadogan, Diarmaid, Lecumberri, Iñigo, Thwaite, Erica, Kruk, Mariusz, Neskovic, Aleksandar N., Mancone, Massimo, Kuśmierz, Donata, Feuchtner, Gudrun, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Cau, Riccardo, Fisher, Michael, Merkely, Bela, Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, del Blanco, Bruno García, Rubio, Ainhoa, Szilveszter, Bálint, Hove, Jens D., Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Édes, István Ferenc, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Serna-Higuita, Lina M., Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Budoff, Matthew J., Estrella, Melanie, Martus, Peter, Bosserdt, Maria, Dewey, Marc, Biavati, Federico, Saba, Luca, Boussoussou, Melinda, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodríguez-Palomares, José, Erglis, Andrejs, Štěchovský, Cyril, Šakalytė, Gintarė, Ađić, Nada Čemerlić, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jacqueline, Maurovich-Horvat, Pál, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtěch, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Cadogan, Diarmaid, Lecumberri, Iñigo, Thwaite, Erica, Kruk, Mariusz, Neskovic, Aleksandar N., Mancone, Massimo, Kuśmierz, Donata, Feuchtner, Gudrun, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Cau, Riccardo, Fisher, Michael, Merkely, Bela, Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, del Blanco, Bruno García, Rubio, Ainhoa, Szilveszter, Bálint, Hove, Jens D., Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Édes, István Ferenc, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Serna-Higuita, Lina M., Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Budoff, Matthew J., Estrella, Melanie, Martus, Peter, Bosserdt, Maria, and Dewey, Marc

Abstract

Background Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA. Participants were randomly assigned to undergo either ICA or coronary CT. CAC scores from noncontrast CT scans were categorized into low, intermediate, and high groups based on scores of 0, 1–399, and 400 or higher, respectively. The end point of the study was the occurrence of MACE (myocardial infarction, stroke, and cardiovascular death) over a median 3.5-year follow-up, analyzed using Cox proportional hazard regression tests. Results The study involved 1749 participants (mean age, 60 years ± 10 [SD]; 992 female). The prevalence of obstructive coronary artery disease (CAD) at CT angiography rose from 4.1% (95% CI: 2.8, 5.8) in the CAC score 0 group to 76.1% (95% CI: 70.3, 81.2) in the CAC score 400 or higher group. Revascularization rates increased from 1.7% to 46.2% across the same groups (P < .001). The CAC score 0 group had a lower MACE risk (0.5%; HR, 0.08 [95% CI: 0.02, 0.30]; P < .001), as did the 1–399 CAC score group (1.9%; HR, 0.27 [95% CI: 0.13, 0.59]; P = .001), compared with the 400 or higher CAC score group (6.8%). No significant difference in MACE between sexes was observed (P = .68). Conclusion In participants with stable chest pain initially referred for ICA, a CAC score of 0 showed very low risk, Background: Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose: To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods: This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA. Participants were randomly assigned to undergo either ICA or coronary CT. CAC scores from noncontrast CT scans were categorized into low, intermediate, and high groups based on scores of 0, 1-399, and 400 or higher, respectively. The end point of the study was the occurrence of MACE (myocardial infarction, stroke, and cardiovascular death) over a median 3.5-year follow-up, analyzed using Cox proportional hazard regression tests. Results: The study involved 1749 participants (mean age, 60 years ± 10 [SD]; 992 female). The prevalence of obstructive coronary artery disease (CAD) at CT angiography rose from 4.1% (95% CI: 2.8, 5.8) in the CAC score 0 group to 76.1% (95% CI: 70.3, 81.2) in the CAC score 400 or higher group. Revascularization rates increased from 1.7% to 46.2% across the same groups (P < .001). The CAC score 0 group had a lower MACE risk (0.5%; HR, 0.08 [95% CI: 0.02, 0.30]; P < .001), as did the 1-399 CAC score group (1.9%; HR, 0.27 [95% CI: 0.13, 0.59]; P = .001), compared with the 400 or higher CAC score group (6.8%). No significant difference in MACE between sexes was observed (P = .68). Conclusion: In participants with stable chest pain initially referred for ICA, a CAC score of 0 showed very low risk of MACE, and higher CAC scores showed increasin

Published
2024

3. Erratum. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease. Diabetes Care 2023;46:2015–2023

Author

Benedek, Theodora, primary, Wieske, Viktoria, additional, Szilveszter, Bálint, additional, Kofoed, Klaus F., additional, Donnelly, Patrick, additional, Rodriguez-Palomares, José, additional, Erglis, Andrejs, additional, Veselka, Josef, additional, Šakalytė, Gintarė, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhani, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Hansen, Kristian Schultz, additional, Müller-Nordhorn, Jacqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Horváth, Martin, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Mulvihill, Niall, additional, Lecumberri, Iñigo, additional, Thwaite, Erica, additional, Laule, Michael, additional, Kruk, Mariusz, additional, Stefanovic, Milica, additional, Mancone, Massimo, additional, Kuśmierz, Donata, additional, Feuchtner, Gudrun, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Melis, Marco, additional, Fisher, Michael, additional, Boussoussou, Melinda, additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, Blanco, Bruno Garcia del, additional, Rubio, Ainhoa, additional, Károlyi, Mihály, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Gellér, László, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Serna-Higuita, Lina M., additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Danesh, John, additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2024
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4. Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial

Author

Mancone, Massimo, primary, Mézquita, Aldo J. Vázquez, additional, Birtolo, Lucia Ilaria, additional, Maurovich-Horvat, Pal, additional, Kofoed, Klaus F., additional, Benedek, Theodora, additional, Donnelly, Patrick, additional, Rodriguez-Palomares, Jose, additional, Erglis, Andrejs, additional, Štěchovský, Cyril, additional, Šakalytė, Gintare, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhanni, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Hansen, Kristian Schultz, additional, Müller-Nordhorn, Jaqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Suchánek, Vojtěch, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Keane, Stephen, additional, Lecumberri, Ignacio, additional, Thwaite, Erica, additional, Kruk, Mariusz, additional, Jovanovic, Vladimir, additional, Kuśmierz, Donata, additional, Feuchtner, Gudren, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Palmisano, Vitanio, additional, Fisher, Michael, additional, Drobni, Zsófia D., additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, del Blanco, Bruno Garcia, additional, Rubio, Ainhoa, additional, Boussoussou, Melinda, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Becker, Dávid, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Wieske, Viktoria, additional, Douglas, Pamela S., additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Serna-Higuita, Lina M., additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2023
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5. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease

Author

Benedek, Theodora, primary, Wieske, Viktoria, additional, Szilveszter, Bálint, additional, Kofoed, Klaus F., additional, Donnelly, Patrick, additional, Rodriguez-Palomares, José, additional, Erglis, Andrejs, additional, Veselka, Josef, additional, Šakalytė, Gintarė, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhani, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Schultz Hansen, Kristian, additional, Müller-Nordhorn, Jacqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Horváth, Martin, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Mulvihill, Niall, additional, Lecumberri, Iñigo, additional, Thwaite, Erica, additional, Laule, Michael, additional, Kruk, Mariusz, additional, Stefanovic, Milica, additional, Mancone, Massimo, additional, Kuśmierz, Donata, additional, Feuchtner, Gudrun, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Melis, Marco, additional, Fisher, Michael, additional, Boussoussou, Melinda, additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, Garcia del Blanco, Bruno, additional, Rubio, Ainhoa, additional, Károlyi, Mihály, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Gellér, László, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Serna-Higuita, Lina M., additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Danesh, John, additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2023
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7. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease

Author

Benedek, Theodora, Wieske, Viktoria, Szilveszter, Bálint, Kofoed, Klaus F., Donnelly, Patrick, Rodriguez-Palomares, José, Erglis, Andrejs, Veselka, Josef, Šakalytė, Gintarė, Ađić, Nada Čemerlić, Gutberlet, Matthias, Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Schultz Hansen, Kristian, Müller-Nordhorn, Jacqueline, Merkely, Bela, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Horváth, Martin, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Mulvihill, Niall, Lecumberri, Iñigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Stefanovic, Milica, Mancone, Massimo, Kuśmierz, Donata, Feuchtner, Gudrun, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Melis, Marco, Fisher, Michael, Boussoussou, Melinda, Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, Garcia Del Blanco, Bruno, Rubio, Ainhoa, Károlyi, Mihály, Hove, Jens D., Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Gellér, László, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Serna-Higuita, Lina M., Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Danesh, John, Estrella, Melanie, Bosserdt, Maria, Martus, Peter, Dodd, Jonathan D., Dewey, Marc, Benedek, Theodora, Wieske, Viktoria, Szilveszter, Bálint, Kofoed, Klaus F., Donnelly, Patrick, Rodriguez-Palomares, José, Erglis, Andrejs, Veselka, Josef, Šakalytė, Gintarė, Ađić, Nada Čemerlić, Gutberlet, Matthias, Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Schultz Hansen, Kristian, Müller-Nordhorn, Jacqueline, Merkely, Bela, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Horváth, Martin, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Mulvihill, Niall, Lecumberri, Iñigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Stefanovic, Milica, Mancone, Massimo, Kuśmierz, Donata, Feuchtner, Gudrun, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Melis, Marco, Fisher, Michael, Boussoussou, Melinda, Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, Garcia Del Blanco, Bruno, Rubio, Ainhoa, Károlyi, Mihály, Hove, Jens D., Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Gellér, László, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Serna-Higuita, Lina M., Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Danesh, John, Estrella, Melanie, Bosserdt, Maria, Martus, Peter, Dodd, Jonathan D., and Dewey, Marc

Abstract

OBJECTIVE To compare cardiac computed tomography (CT) with invasive coronary angiography (ICA) as the initial strategy in patients with diabetes and stable chest pain. RESEARCH DESIGN AND METHODS This prespecified analysis of the multicenter DISCHARGE trial in 16 European countries was performed in patients with stable chest pain and intermediate pretest probability of coronary artery disease. The primary end point was a major adverse cardiac event (MACE) (cardiovascular death, nonfatal myocardial infarction, or stroke), and the secondary end point was expanded MACE (including transient ischemic attacks and major procedure-related complications). RESULTS Follow-up at a median of 3.5 years was available in 3,541 patients of whom 557 (CT group n = 263 vs. ICA group n = 294) had diabetes and 2,984 (CT group n = 1,536 vs. ICA group n = 1,448) did not. No statistically significant diabetes interaction was found for MACE (P = 0.45), expanded MACE (P = 0.35), or major procedure-related complications (P = 0.49). In both patients with and without diabetes, the rate of MACE did not differ between CT and ICA groups. In patients with diabetes, the expanded MACE end point occurred less frequently in the CT group than in the ICA group (3.8% [10 of 263] vs. 8.2% [24 of 294], hazard ratio [HR] 0.45 [95% CI 0.22–0.95]), as did the major procedure-related complication rate (0.4% [1 of 263] vs. 2.7% [8 of 294], HR 0.30 [95% CI 0.13 – 0.63]). CONCLUSIONS In patients with diabetes referred for ICA for the investigation of stable chest pain, a CT-first strategy compared with an ICA-first strategy showed no difference in MACE and may potentially be associated with a lower rate of expanded MACE and major procedure-related complications., OBJECTIVE: To compare cardiac computed tomography (CT) with invasive coronary angiography (ICA) as the initial strategy in patients with diabetes and stable chest pain. RESEARCH DESIGN AND METHODS: This prespecified analysis of the multicenter DISCHARGE trial in 16 European countries was performed in patients with stable chest pain and intermediate pretest probability of coronary artery disease. The primary end point was a major adverse cardiac event (MACE) (cardiovascular death, nonfatal myocardial infarction, or stroke), and the secondary end point was expanded MACE (including transient ischemic attacks and major procedure-related complications). RESULTS: Follow-up at a median of 3.5 years was available in 3,541 patients of whom 557 (CT group n = 263 vs. ICA group n = 294) had diabetes and 2,984 (CT group n = 1,536 vs. ICA group n = 1,448) did not. No statistically significant diabetes interaction was found for MACE (P = 0.45), expanded MACE (P = 0.35), or major procedure-related complications (P = 0.49). In both patients with and without diabetes, the rate of MACE did not differ between CT and ICA groups. In patients with diabetes, the expanded MACE end point occurred less frequently in the CT group than in the ICA group (3.8% [10 of 263] vs. 8.2% [24 of 294], hazard ratio [HR] 0.45 [95% CI 0.22-0.95]), as did the major procedure-related complication rate (0.4% [1 of 263] vs. 2.7% [8 of 294], HR 0.30 [95% CI 0.13 - 0.63]). CONCLUSIONS: In patients with diabetes referred for ICA for the investigation of stable chest pain, a CT-first strategy compared with an ICA-first strategy showed no difference in MACE and may potentially be associated with a lower rate of expanded MACE and major procedure-related complications.

Published
2023

8. A Machine-Learning Framework to Identify Distinct Phenotypes of Aortic Stenosis Severity

Author

Sengupta, Partho P., primary, Shrestha, Sirish, additional, Kagiyama, Nobuyuki, additional, Hamirani, Yasmin, additional, Kulkarni, Hemant, additional, Yanamala, Naveena, additional, Bing, Rong, additional, Chin, Calvin W.L., additional, Pawade, Tania A., additional, Messika-Zeitoun, David, additional, Tastet, Lionel, additional, Shen, Mylène, additional, Newby, David E., additional, Clavel, Marie-Annick, additional, Pibarot, Phillippe, additional, Dweck, Marc R., additional, Larose, Éric, additional, Guzzetti, Ezequiel, additional, Bernier, Mathieu, additional, Beaudoin, Jonathan, additional, Arsenault, Marie, additional, Côté, Nancy, additional, Everett, Russell, additional, Jenkins, William S.A., additional, Tribouilloy, Christophe, additional, Dreyfus, Julien, additional, Mathieu, Tiffany, additional, Renard, Cedric, additional, Gun, Mesut, additional, Macron, Laurent, additional, Sechrist, Jacob W., additional, Lacomis, Joan M., additional, Nguyen, Virginia, additional, Gay, Laura Galian, additional, Calabria, Hug Cuéllar, additional, Ntalas, Ioannis, additional, Prendergast, Bernard, additional, Rajani, Ronak, additional, Evangelista, Arturo, additional, and Cavalcante, João L., additional

Published
2021
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9. Predictors of cardiovascular outcomes after surgery in severe tricuspid regurgitation: clinical, imaging and hemodynamic prospective study

Author

Rodríguez-Palomares, José F., primary, Lozano-Torres, Jordi, additional, Dentamaro, Ilaria, additional, Valente, Filipa X., additional, Avilés, Augusto Sao, additional, García-Moreno, Laura Gutiérrez, additional, Sabaté, Pau Rello, additional, Otaegui, Imanol, additional, Rosique, Beatriz Mínguez, additional, Calabria, Hug Cuéllar, additional, Masip, Artur Evangelista, additional, Mas, Pilar Tornos, additional, Ferreira-González, Ignacio, additional, and González-Alujas, María Teresa, additional

Published
2021
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10. Intraventricular Conundrum in a SARS-CoV-2-Positive Patient With Elevated Biomarkers of Myocardial Injury

Author

Servato, María L., Valente, Filipa, García-Moreno, Laura Gutiérrez, Casas, Guillem, Fernández-Galera, Ruben, Burcet, Gemma, Teixidó-Tura, Gisela, Calabria, Hug Cuéllar, González, Ignacio Ferreira, Rodríguez-Palomares, José F., Universitat Autònoma de Barcelona, Institut Català de la Salut, [Servato ML, Valente FX, García-Moreno LG, Casas G, Fernández-Galera R, Teixidó-Tura G, Rodríguez-Palomares JF] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Center for Biomedical Investigation Cardiovascular Consortium, Madrid, Spain. [Burcet G, Calabria HC] Servei de Radiologia, Institut d’Imatge per al Diagnòstic, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [González IF] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Center for Biomedical Investigation Epidemiology and Public Health Consortium, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, viruses, enfermedades cardiovasculares::enfermedades cardíacas::miocardiopatías::miocarditis [ENFERMEDADES], Case Report, 030105 genetics & heredity, COVID-19 (Malaltia), 0302 clinical medicine, CMR, cardiac magnetic resonance, LVEF, left ventricular ejection fraction, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Medicine, echocardiography, Fio2, fraction of inspired oxygen, Computed tomography, Pneumònia vírica, COVID-19, coronavirus disease-2019, NT-proBNP, N-terminal pro-B-type natriuretic peptide, SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2, virus diseases, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], enfermedades respiratorias::enfermedades respiratorias::infecciones del tracto respiratorio::neumonía::neumonía vírica [ENFERMEDADES], Positive patient, Thrombosis, Fi, fraction of inspired oxygen, Myocarditis, thrombus, Echocardiography, Cardiology, cardiovascular system, Cardiology and Cardiovascular Medicine, cardiovascular magnetic resonance (CMR), Thrombus, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Other subheadings::Other subheadings::Other subheadings::/virology [Other subheadings], Miocarditis - Tractament, 03 medical and health sciences, Clinical Case, Internal medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, LV, left ventricular, Otros calificadores::Otros calificadores::Otros calificadores::/virología [Otros calificadores], business.industry, COVID-19, computed tomography, medicine.disease, Atypical pneumonia, RC666-701, Heart failure, NT-proBNP, N-terminal pro–B-type natriuretic peptide, myocarditis, Respiratory Tract Diseases::Respiratory Tract Diseases::Respiratory Tract Infections::Pneumonia::Pneumonia, Viral [DISEASES], business, Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Myocarditis [DISEASES], 030217 neurology & neurosurgery, Cardiovascular magnetic resonance (CMR)
Abstract

We present a case of acute myocarditis with left ventricular dysfunction and intracavitary thrombosis in a 55-year-old man with severe acute respiratory syndrome coronavirus 2 infection (coronavirus disease 2019) who was admitted with bilateral atypical pneumonia. The patient was treated with anticoagulation and optimal heart failure therapy and had an improvement of left ventricular function and thrombus resolution. (Level of Difficulty: Intermediate.), Graphical abstract

Published
2021

11. Intraventricular Conundrum in a SARS-CoV-2–Positive Patient With Elevated Biomarkers of Myocardial Injury

Author

Servato, María L., primary, Valente, Filipa X., additional, García-Moreno, Laura Gutiérrez, additional, Casas, Guillem, additional, Fernández-Galera, Rubén, additional, Burcet, Gemma, additional, Teixidó-Tura, Gisela, additional, Calabria, Hug Cuéllar, additional, González, Ignacio Ferreira, additional, and Rodríguez-Palomares, José F., additional

Published
2021
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12. Effect of Body Mass Index on Effectiveness of CT versus Invasive Coronary Angiography in Stable Chest Pain: The DISCHARGE Trial

Author

Sykes, Robert, Collison, Damien, Merkely, Bela, Kofoed, Klaus F., Donnelly, Patrick, Rodríguez-Palomares, José, Erglis, Andrejs, Veselka, Josef, Šakalytė, Gintarė, Ađić, Nada Čemerlić, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jacqueline, Maurovich-Horvat, Pál, Knudsen, Andreas D., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Horváth, Martin, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Keane, Stephen, Lecumberri, Iñigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Zivanic, Aleksandra, Mancone, Massimo, Kuśmierz, Donata, Feuchtner, Gudrun, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Porcu, Michele, Fisher, Michael, Bárány, Tamás, Sørum, Charlotte, Aurelian, Rosca, Kelly, Stephanie, Blanco, Bruno Garcia del, Rubio, Ainhoa, Szilveszter, Bálint, Abdulla, Jawdat, Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Vecsey-Nagy, Milán, Jurlander, Birgit, Hodas, Roxana, Feger, Sarah, Mohamed, Mahmoud, Serna-Higuita, Lina M., Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Ferencik, Maros, Estrella, Melanie, Bosserdt, Maria, Martus, Peter, Benedek, Theodora, and Dewey, Marc

Abstract

When patients suspected of having coronary artery disease were stratified by body mass index category, no difference in clinical outcomes was observed between those who underwent initial management with CT and those who underwent invasive coronary angiography.

Published
2024
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13. Computed Tomography Aortic Valve Calcium Scoring in Patients With Aortic Stenosis.

Author

Pawade, Tania, Clavel, Marie-Annick, Tribouilloy, Christophe, Dreyfus, Julien, Mathieu, Tiffany, Tastet, Lionel, Renard, Cedric, Gun, Mesut, Arthur Jenkins, William Steven, Macron, Laurent, Sechrist, Jacob W., Lacomis, Joan M., Nguyen, Virginia, Galian Gay, Laura, Calabria, Hug Cuéllar, Ntalas, Ioannis, Graham Cartlidge, Timothy Robert, Prendergast, Bernard, Rajani, Ronak, and Evangelista, Arturo

Abstract

Background--Computed tomography aortic valve calcium scoring (CT-AVC) holds promise for the assessment of patients with aortic stenosis (AS). We sought to establish the clinical utility of CT-AVC in an international multicenter cohort of patients. Methods and Results--Patients with AS who underwent ECG-gated CT-AVC within 3 months of echocardiography were entered into an international, multicenter, observational registry. Optimal CT-AVC thresholds for diagnosing severe AS were determined in patients with concordant echocardiographic assessments, before being used to arbitrate disease severity in those with discordant measurements. In patients with long-term follow-up, we assessed whether CT-AVC thresholds predicted aortic valve replacement and death. In 918 patients from 8 centers (age, 77±10 years; 60% men; peak velocity, 3.88±0.90 m/s), 708 (77%) patients had concordant echocardiographic assessments, in whom CT-AVC provided excellent discrimination for severe AS (C statistic: women 0.92, men 0.89). Our optimal sex-specific CT-AVC thresholds (women 1377 Agatston unit and men 2062 Agatston unit) were nearly identical to those previously reported (women 1274 Agatston unit and men 2065 Agatston unit). Clinical outcomes were available in 215 patients (follow-up 1029 [126-2251] days). Sex-specific CT-AVC thresholds independently predicted aortic valve replacement and death (hazard ratio, 3.90 [95% confidence interval, 2.19-6.78]; P<0.001) after adjustment for age, sex, peak velocity, and aortic valve area. Among 210 (23%) patients with discordant echocardiographic assessments, there was considerable heterogeneity in CT-AVC scores, which again were an independent predictor of clinical outcomes (hazard ratio, 3.67 [95% confidence interval, 1.39-9.73]; P=0.010). Conclusions--Sex-specific CT-AVC thresholds accurately identify severe AS and provide powerful prognostic information. These findings support their integration into routine clinical practice. Clinical Trial Registration--URL: http://www.clinicaltrials.gov. Unique identifiers: NCT01358513, NCT02132026, NCT00338676, NCT00647088, NCT01679431. [ABSTRACT FROM AUTHOR]

Published
2018
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