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43 results on '"Calabrese, Michelle A."'

2. Engineering large-scale hiPSC-derived vessel-integrated muscle-like lattices for enhanced volumetric muscle regeneration

Author

Lee, Myung Chul, Jodat, Yasamin A., Endo, Yori, Rodríguez-delaRosa, Alejandra, Zhang, Ting, Karvar, Mehran, Al Tanoury, Ziad, Quint, Jacob, Kamperman, Tom, Kiaee, Kiavash, Ochoa, Sofia Lara, Shi, Kun, Huang, Yike, Rosales, Montserrat Pineda, Arnaout, Adnan, Lee, Hyeseon, Kim, Jiseong, Ceron, Eder Luna, Reyes, Isaac Garcia, Panayi, Adriana C., Martinez, Angel Flores Huidobro, Wang, Xichi, Kim, Ki-Tae, Moon, Jae-I, Park, Seung Gwa, Lee, Kangju, Calabrese, Michelle A., Hassan, Shabir, Lee, Junmin, Tamayol, Ali, Lee, Luke, Pourquié, Olivier, Kim, Woo-Jin, Sinha, Indranil, and Shin, Su Ryon

Published
2024
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7. Low-Intensity Magnetic Fields Induce Anomalous Disorder-to-Order Transition in Spherical Block Copolymer Micelle Solutions

Author

Kresge, Grace V., Neal, Christopher A. P., and Calabrese, Michelle A.

Abstract

Magnetic field processing is promising for directing and enhancing self-assembly of diamagnetic block copolymers (BCPs) via domain alignmentbut is typically limited to high field strengths and few polymer chemistries. Herein, a novel magnetic field-induced ordering mechanism distinct from domain alignment is demonstrated in aqueous, spherical BCP micelles. Here, low-intensity magnetic fields (B≤ 0.5 T) induce an anomalous disorder-to-order transition, accompanied by a several order-of-magnitude increase in shear modulus, effectively transforming a low viscosity liquid into an ordered soft solid. The induced moduli are orders of magnitude larger than those resulting from thermally-induced ordering. Further magnetization induces cubic-to-cylinder order-to-order transitions. Comprehensive characterization via magnetorheology, small- and wide-angle X-ray scattering, differential scanning calorimetry, and vibrational spectroscopy reveals a significant reduction in micelle size and aggregation number relative to zero-field temperature- or concentration-induced ordering, suggesting that B-fields strongly alter polymer–solvent interactions. This extraordinary BCP ordering strategy enables the discovery of structures and d-spacings inaccessible via traditional processing routes, thus providing a new platform for developing advanced materials with precisely controlled features.

Published
2025
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11. Effect of Mechanical Compression on Chemical Degradation of Nafion Membranes

Author

Kusoglu, Ahmet, Calabrese, Michelle, and Weber, Adam Z

Subjects
Affordable and Clean Energy, Physical Chemistry (incl. Structural), Chemical Engineering, Materials Engineering, Energy
Abstract

The effect of compression on the chemical degradation of Nafion is investigated. Results indicate a nonlinear dependence of chemical degradation on compression level, with a slight decrease at 1 MPa and then increase up to 10MPa. The results confirm the synergistic nature of mechanical effects on chemical fuel-cell membrane degradation, which are expected to occur in operando. The impact of compression is also shown to change the nano-domain structure, consistent with the increase in chemical decomposition. Thus, deformation energy accumulated in the membrane due to mechanical loads seemingly accelerates the chemical reactions driving the decomposition of the polymer membrane. © 2014 The Electrochemical Society.

Published
2014

17. 35+1 challenges in materials science being tackled by PIs under 35(ish) in 2023

Author

Allen, Monica, primary, Bediako, Kwabena, additional, Bowman, William J., additional, Calabrese, Michelle, additional, Caretta, Lucas, additional, Cersonsky, Rose K., additional, Chen, Wen, additional, Correa, Santiago, additional, Davidson, Rachel, additional, Dresselhaus-Marais, Leora, additional, Eisler, Carissa N., additional, Furst, Ariel, additional, Ge, Ting, additional, Hook, Andrew, additional, Hsu, Yi-Ting, additional, Jia, Chunjing, additional, Lu, Jianfeng, additional, Lunghi, Alessandro, additional, Messina, Marco S., additional, Moreno-Hernandez, Ivan A., additional, Nichols, Eva, additional, Rao, Reshma, additional, Seifrid, Martin, additional, Shulenberger, Katherine Emily, additional, Simonov, Alexandr N., additional, Su, Xiao, additional, Swearer, Dayne F., additional, Tang, Evelyn, additional, Taylor, Mercedes K., additional, Tran, Helen, additional, Trindade, Gustavo F., additional, Truby, Ryan, additional, Utzat, Hendrik, additional, Yang, Ying, additional, Yee, Daryl W., additional, Zhao, Shenlong, additional, and Cranford, Steve, additional

Published
2023
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23. Effect of nanoparticle loading and magnetic field application on the thermodynamic, optical, and rheological behavior of thermoresponsive polymer solutions.

Author

Neal, Christopher A. P., Kresge, Grace V., Quan, Michelle C., León, Valeria, Chibambo, Nondumiso O., and Calabrese, Michelle A.

Subjects
THERMORESPONSIVE polymers, POLYMER solutions, THERMODYNAMICS, MAGNETICS, MAGNETIC fields, MAGNETIC transitions
Abstract

Although processing via external stimuli is a promising technique to tune the structure and properties of polymeric materials, the impact of magnetic fields on phase transitions in thermoresponsive polymer solutions is not well‐understood. As nanoparticle (NP) addition is also known to impact these thermodynamic and optical properties, synergistic effects from combining magnetic fields with NP incorporation provide a novel route for tuning material properties. Here, the thermodynamic, optical, and rheological properties of aqueous poly(N‐isopropyl acrylamide) (PNIPAM) solutions are examined in the presence of hydrophilic silica NPs and magnetic fields, individually and jointly, via Fourier‐transform infrared spectroscopy (FTIR), magneto‐turbidimetry, differential scanning calorimetry (DSC), and magneto‐rheology. While NPs and magnetic fields both reduce the phase separation energy barrier and lower optical transition temperatures by altering hydrogen bonding (H‐bonding), infrared spectra demonstrate that the mechanism by which these changes occur is distinct. Magnetic fields primarily alter solvent polarization while NPs provide PNIPAM–NP H‐bonding sites. Combining NP addition with field application uniquely alters the solution environment and results in field‐dependent rheological behavior that is unseen in polymer‐only solutions. These investigations provide fundamental understanding on the interplay of magnetic fields and NP addition on PNIPAM thermoresponsivity which can be harnessed for increasingly complex stimuli‐responsive materials. [ABSTRACT FROM AUTHOR]

Published
2023
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32. hiPSC-derived 3D Bioprinted Skeletal Muscle Tissue Implants Regenerate Skeletal Muscle Following Volumetric Muscle Loss

Author

Jodat, Yasamin A., Zhang, Ting, Tanoury, Ziad Al, Kamperman, Tom, Shi, Kun, Huang, Yike, Panayi, Adriana, Endo, Yori, Wang, Xichi, Quint, Jacob, Arnaout, Adnan, Kiaee, Kiavash, Hassan, Shabir, Lee, Junmin, Martinez, Angel Flores Huidobro, Ochoa, Sofia Lara, Lee, KangJu, Calabrese, Michelle, Carlucci, Alessandro, Tamayol, Ali, Sinha, Indranil, Pourquié, Olivier, Ryon Shin, Su, Developmental BioEngineering, and TechMed Centre

Abstract

Engineering of biomimetic tissue implants provides an opportunity for repairing volumetric muscle loss (VML), beyond a tissue’s innate repair capacity. Here, we present thick, suturable, and pre-vascularized 3D muscle implants containing human induced pluripotent stem cell-derived myogenic precursor cells (hiPSC-MPCs), which can differentiate into skeletal muscle cells while maintaining a self-renewing pool. The formation of contractile myotubes and millimeter-long fibers from hiPSC-MPCs is achieved in chemically, mechanically, and structurally tailored extracellular matrix-based hydrogels, which can serve as scaffolds to ultimately organize the linear fusion of myoblasts. Embedded multi-material bioprinting is used to deposit complex patterns of perfusable vasculatures and aligned hiPSC-MPC channels within an endomysium-like supporting gel to recapitulate muscle architectural integrity in a facile yet highly rapid manner. Moreover, we demonstrate successful graft-host integration and de novo muscle formation upon in vivo implantation of pre-vascularized constructs within a VML model. This work pioneers the engineering of large pre-vascularized hiPSC-derived muscle tissues toward next generation VML regenerative therapies.

Published
2021

33. hiPSC-derived 3D Bioprinted Skeletal Muscle Tissue Implants Regenerate Skeletal Muscle Following Volumetric Muscle Loss

Author

Jodat, Yasamin A., primary, Zhang, Ting, additional, Tanoury, Ziad Al, additional, Kamperman, Tom, additional, Shi, Kun, additional, Huang, Yike, additional, Panayi, Adriana, additional, Endo, Yori, additional, Wang, Xichi, additional, Quint, Jacob, additional, Arnaout, Adnan, additional, Kiaee, Kiavash, additional, Hassan, Shabir, additional, Lee, Junmin, additional, Martinez, Angel Flores Huidobro, additional, Ochoa, Sofia Lara, additional, Lee, KangJu, additional, Calabrese, Michelle, additional, Carlucci, Alessandro, additional, Tamayol, Ali, additional, Sinha, Indranil, additional, Pourquié, Olivier, additional, and Shin, Su Ryon, additional

Published
2021
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36. 3D Printed Tissues: 3D Printed Cartilage‐Like Tissue Constructs with Spatially Controlled Mechanical Properties (Adv. Funct. Mater. 51/2019)

Author

Melo, Bruna A. G., primary, Jodat, Yasamin A., additional, Mehrotra, Shreya, additional, Calabrese, Michelle A., additional, Kamperman, Tom, additional, Mandal, Biman B., additional, Santana, Maria H. A., additional, Alsberg, Eben, additional, Leijten, Jeroen, additional, and Shin, Su Ryon, additional

Published
2019
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41. Dimethylformamide-Mediated Polymer Microstructure Dictates the Extensional Rheology of Aqueous PNIPAM Solutions

Author

Zhang, Diana Y., Schwendinger, Alec J., and Calabrese, Michelle A.

Abstract

Polymer solution processability in extensional-flow-dominated operations is strongly influenced by polymer conformation and solution phase behavior. Cosolvent addition can be used to tailor polymer conformation and solution phase behavior to yield formulations that are amenable to processes such as spraying and atomization, coating, and fiber spinning. The addition of N,N-dimethylformamide (DMF) to aqueous poly(N-isopropylacrylamide) (PNIPAM) solutions induces unique phase behavior and microstructure formation, yet the effects on solution processability have remained unexplored. In this work, the effect of DMF cosolvent content on the rheology (both shear and extensional) and microstructure of PNIPAM solutions is investigated. While all examined PNIPAM solutions exhibit nearly Newtonian steady shear behavior regardless of the DMF content, the same solutions exhibit varying degrees of extensibility. Surprisingly, the extensional relaxation time (λE) increases by more than 20-fold with increasing DMF content in the water-rich regime. In the DMF-rich regime, however, the solution extensibility dramatically decreases. Interestingly, this unique variation in extensional flow behavior does not scale as expected based on changes in the measured intrinsic viscosity and radius of gyration. Instead, a mechanism is proposed that relates the extensional flow behavior to the solution microstructure, which is found to vary with DMF content in light scattering measurements. In the water-rich regime, DMF molecules are proposed to bridge PNIPAM chains via hydrogen bonding and hydrophobic interactions, resulting in physically cross-linked aggregates. In extensional flows, these aggregates behave like a polymer with higher apparent molecular weight, increasing λE. In the DMF-rich regime, nonbridging DMF molecules increasingly solvate individual PNIPAM chains; consequently, more individual chains are stretched in extensional flows, leading to a reduction in λE. These findings demonstrate that interactions between components in these ternary systems have unexpected but significant implications for solution extensional flow behavior. Additionally, in the case of PNIPAM/DMF/water, the processability of polymer-containing formulations can be modulated for spraying or fiber spinning applications just by varying the cosolvent (DMF) content.

Published
2024
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