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1. Computer Vision for Terrain Mapping and 3D Printing In-situ of Extra/-terrestrial Habitats

Author

Calabrese, Giuseppe, Hidding, Arwin, Bier, Henriette, van Engelenburg, Casper, Khademi, Seyran, Aslaminezhad, Atousa, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2024
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2. Review of Cementless Materials for 3D Printing of On- and Off-Earth Habitats

Author

Calabrese, Giuseppe, Hidding, Arwin, Bier, Henriette, Schnädelbach, Holger, Editor-in-Chief, Bier, Henriette, Editor-in-Chief, Van Laerhoven, Kristof, Editor-in-Chief, Alavi, Hamed S., Editorial Board Member, Ameijde, Jeroen van, Editorial Board Member, Dirrenberger, Justin, Editorial Board Member, Gerber, David, Editorial Board Member, Green, Keith, Editorial Board Member, Fatah, Ava, Editorial Board Member, Foth, Marcus, Editorial Board Member, Khan, Omar, Editorial Board Member, Kirk, David, Editorial Board Member, Kortuem, Gerd, Editorial Board Member, Morel, Philippe, Editorial Board Member, Reinhardt, Dagmar, Editorial Board Member, Speed, Chris, Editorial Board Member, Streitz, Norbert, Editorial Board Member, Vanderdonckt, Jean, Editorial Board Member, Vehlken, Sebastian, Editorial Board Member, Wang, Charlie C L, Editorial Board Member, Wiberg, Mikael, Editorial Board Member, Mentler, Tilo, Editorial Board Member, Cervone, Angelo, editor, and Makaya, Advenit, editor

Published
2024
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4. Geology Architecture for Mars and Moon Environment: A Lesson from Morocco

Author

Calabrese, Giuseppe, Taj-Eddine, Kamal, Ori, Gian Gabriele, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, Gawad, Iman O., Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Çiner, Attila, editor, Barbieri, Maurizio, editor, Khan, Md Firoz, editor, Ugulu, Ilker, editor, Turan, Veysel, editor, Knight, Jasper, editor, Rodrigo-Comino, Jesús, editor, Chenchouni, Haroun, editor, Radwan, Ahmed E., editor, Kallel, Amjad, editor, Panagoulia, Dionysia, editor, Candeias, Carla, editor, Biswas, Arkoprovo, editor, Chaminé, Helder I., editor, Gentilucci, Matteo, editor, Bezzeghoud, Mourad, editor, and Ergüler, Zeynal Abiddin, editor

Published
2024
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11. Author Correction: Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Author

Wang, Tianyun, Hoekzema, Kendra, Vecchio, Davide, Wu, Huidan, Sulovari, Arvis, Coe, Bradley P, Gillentine, Madelyn A, Wilfert, Amy B, Perez-Jurado, Luis A, Kvarnung, Malin, Sleyp, Yoeri, Earl, Rachel K, Rosenfeld, Jill A, Geisheker, Madeleine R, Han, Lin, Du, Bing, Barnett, Chris, Thompson, Elizabeth, Shaw, Marie, Carroll, Renee, Friend, Kathryn, Catford, Rachael, Palmer, Elizabeth E, Zou, Xiaobing, Ou, Jianjun, Li, Honghui, Guo, Hui, Gerdts, Jennifer, Avola, Emanuela, Calabrese, Giuseppe, Elia, Maurizio, Greco, Donatella, Lindstrand, Anna, Nordgren, Ann, Anderlid, Britt-Marie, Vandeweyer, Geert, Van Dijck, Anke, Van der Aa, Nathalie, McKenna, Brooke, Hancarova, Miroslava, Bendova, Sarka, Havlovicova, Marketa, Malerba, Giovanni, Bernardina, Bernardo Dalla, Muglia, Pierandrea, van Haeringen, Arie, Hoffer, Mariette JV, Franke, Barbara, Cappuccio, Gerarda, Delatycki, Martin, Lockhart, Paul J, Manning, Melanie A, Liu, Pengfei, Scheffer, Ingrid E, Brunetti-Pierri, Nicola, Rommelse, Nanda, Amaral, David G, Santen, Gijs WE, Trabetti, Elisabetta, Sedláček, Zdeněk, Michaelson, Jacob J, Pierce, Karen, Courchesne, Eric, Kooy, R Frank, Nordenskjöld, Magnus, Romano, Corrado, Peeters, Hilde, Bernier, Raphael A, Gecz, Jozef, Xia, Kun, and Eichler, Evan E

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Commerce, Management, Tourism and Services, SPARK Consortium
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

12. Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Author

Wang, Tianyun, Hoekzema, Kendra, Vecchio, Davide, Wu, Huidan, Sulovari, Arvis, Coe, Bradley P, Gillentine, Madelyn A, Wilfert, Amy B, Perez-Jurado, Luis A, Kvarnung, Malin, Sleyp, Yoeri, Earl, Rachel K, Rosenfeld, Jill A, Geisheker, Madeleine R, Han, Lin, Du, Bing, Barnett, Chris, Thompson, Elizabeth, Shaw, Marie, Carroll, Renee, Friend, Kathryn, Catford, Rachael, Palmer, Elizabeth E, Zou, Xiaobing, Ou, Jianjun, Li, Honghui, Guo, Hui, Gerdts, Jennifer, Avola, Emanuela, Calabrese, Giuseppe, Elia, Maurizio, Greco, Donatella, Lindstrand, Anna, Nordgren, Ann, Anderlid, Britt-Marie, Vandeweyer, Geert, Van Dijck, Anke, Van der Aa, Nathalie, McKenna, Brooke, Hancarova, Miroslava, Bendova, Sarka, Havlovicova, Marketa, Malerba, Giovanni, Bernardina, Bernardo Dalla, Muglia, Pierandrea, van Haeringen, Arie, Hoffer, Mariette JV, Franke, Barbara, Cappuccio, Gerarda, Delatycki, Martin, Lockhart, Paul J, Manning, Melanie A, Liu, Pengfei, Scheffer, Ingrid E, Brunetti-Pierri, Nicola, Rommelse, Nanda, Amaral, David G, Santen, Gijs WE, Trabetti, Elisabetta, Sedláček, Zdeněk, Michaelson, Jacob J, Pierce, Karen, Courchesne, Eric, Kooy, R Frank, Nordenskjöld, Magnus, Romano, Corrado, Peeters, Hilde, Bernier, Raphael A, Gecz, Jozef, Xia, Kun, and Eichler, Evan E

Subjects
Genetics, Prevention, 2.1 Biological and endogenous factors, Aetiology, Basic Helix-Loop-Helix Transcription Factors, CCCTC-Binding Factor, Case-Control Studies, Cohort Studies, DNA Mutational Analysis, DNA-Binding Proteins, Female, Genetic Association Studies, Genetic Predisposition to Disease, Heterogeneous-Nuclear Ribonucleoprotein U, High-Throughput Nucleotide Sequencing, Humans, KCNQ3 Potassium Channel, Male, Mutation, Neurodevelopmental Disorders, RNA-Binding Proteins, Repressor Proteins, Transcription Factors, SPARK Consortium
Abstract

Most genes associated with neurodevelopmental disorders (NDDs) were identified with an excess of de novo mutations (DNMs) but the significance in case-control mutation burden analysis is unestablished. Here, we sequence 63 genes in 16,294 NDD cases and an additional 62 genes in 6,211 NDD cases. By combining these with published data, we assess a total of 125 genes in over 16,000 NDD cases and compare the mutation burden to nonpsychiatric controls from ExAC. We identify 48 genes (25 newly reported) showing significant burden of ultra-rare (MAF

Published
2020

14. The Crucial Role of Hereditary Cancer Panel Testing in Unaffected Individuals with a Strong Family History of Cancer: A Retrospective Study of a Cohort of 103 Healthy Subjects

Author

Pilenzi, Lucrezia, primary, Anaclerio, Federico, additional, Dell’Elice, Anastasia, additional, Minelli, Maria, additional, Giansante, Roberta, additional, Cicirelli, Michela, additional, Tinari, Nicola, additional, Grassadonia, Antonino, additional, Pantalone, Andrea, additional, Grossi, Simona, additional, Canale, Nicole, additional, Bruno, Annalisa, additional, Calabrese, Giuseppe, additional, Ballerini, Patrizia, additional, Stuppia, Liborio, additional, and Antonucci, Ivana, additional

Published
2024
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17. Uniportal Video-Assisted Thoracoscopic Anatomic Lung Resection after Neoadjuvant Chemotherapy for Lung Cancer: A Case-Matched Analysis †.

Author

Andolfi, Marco, Meacci, Elisa, Salati, Michele, Xiumè, Francesco, Roncon, Alberto, Guiducci, Gian Marco, Tiberi, Michela, Nanto, Anna Chiara, Nachira, Dania, Nocera, Adriana, Calabrese, Giuseppe, Congedo, Maria Teresa, Inchingolo, Riccardo, Margaritora, Stefano, and Refai, Majed

Subjects
TREATMENT of lung tumors, VIDEO-assisted thoracic surgery, CARDIOPULMONARY system physiology, PROBABILITY theory, PATIENT readmissions, TREATMENT effectiveness, RETROSPECTIVE studies, OPERATIVE surgery, SURGICAL complications, LUNG tumors, COMBINED modality therapy, COMPARATIVE studies, LENGTH of stay in hospitals, PERIOPERATIVE care, TIME
Abstract

Simple Summary: In cases of advanced lung cancer after neoadjuvant chemotherapy (nCT), the role of uniportal video-assisted thoracoscopic surgery (U-VATS) is still questionable, with concerns about safety, technical feasibility, and oncological completeness. The aim of this retrospective study was to assess the impact of nCT on patients who had undergone U-VATS anatomic lung resections for lung cancer. We compared the short-term outcomes of 60 patients with case-matched counterparts (treated by surgery alone) selected by propensity score analysis, finding that U-VATS after nCT is a feasible approach with a similar rate of cardiopulmonary complications, length of stay, and readmission when compared with the control group. However, it is still a challenging surgery due to the great technical complexity, which is responsible for the higher incidence of conversion. Background: The advantages of video-assisted thoracic surgery (VATS) are well-recognized in several studies. However, in the cases of advanced lung cancer after neoadjuvant chemotherapy (nCT), the role of VATS is still questionable, with concerns about safety, technical feasibility, and oncological completeness. The aim of this study was to assess the impact of nCT on patients who had undergone uniportal VATS (U-VATS) anatomic lung resections for lung cancer, by comparing the short-term outcomes of patients after nCT with case-matched counterparts (treated by surgery alone). Methods: We performed a retrospective, comparative study enrolling 927 patients (nCT: 60; non-nCT:867) who underwent U-VATS anatomic lung resections from 2014 to 2020 in two centers. Data were collected in a shared database with standardized variables' definition. Propensity score matching using 15 baseline preoperative patients' characteristics was performed in order to minimize selection-confounding factors between the two groups, which then were directly compared in terms of perioperative outcomes. Results: After propensity score matching, two groups of 60 patients had been defined. The nCT-group had a higher conversion rate compared to the control group (13.3% vs. 0%, p = 0.003) without an increase in operation time or cardiopulmonary complications. In addition, no differences between the two groups were recorded in terms of prolonged air leaks, length of stay, and readmission. Conclusions: U-VATS after nCT is a feasible approach, showing a similar rate of cardiopulmonary complications and length of stay when compared with the control group. However, it remains a challenging surgery due to its great technical complexity as well as the clinical status of the patients. [ABSTRACT FROM AUTHOR]

Published
2024
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18. The Crucial Role of Hereditary Cancer Panel Testing in Unaffected Individuals with a Strong Family History of Cancer: A Retrospective Study of a Cohort of 103 Healthy Subjects.

Author

Pilenzi, Lucrezia, Anaclerio, Federico, Dell'Elice, Anastasia, Minelli, Maria, Giansante, Roberta, Cicirelli, Michela, Tinari, Nicola, Grassadonia, Antonino, Pantalone, Andrea, Grossi, Simona, Canale, Nicole, Bruno, Annalisa, Calabrese, Giuseppe, Ballerini, Patrizia, Stuppia, Liborio, and Antonucci, Ivana

Subjects
TUMOR risk factors, TUMOR genetics, RISK assessment, GENOMICS, FAMILIES, RETROSPECTIVE studies, MEDICAL records, ACQUISITION of data, ONCOGENES, GENETIC mutation, INDIVIDUALIZED medicine, GENETIC testing, SEQUENCE analysis
Abstract

Simple Summary: The purpose of this study is to emphasize the importance of genetic testing for healthy individuals with a strong family history of hereditary malignancies. A total of 103 healthy subjects with at least two relatives with cancer were enrolled. By NGS analysis of 27 genes, 5% were found to carry a pathogenic variant in a hereditary cancer susceptibility gene. In the era of personalized medicine, genetic testing of healthy subjects in the absence of a living affected collateral is crucially important for early diagnosis, clinical surveillance and surgical choice. Hereditary cancer syndromes caused by germline mutations account for 5–10% of all cancers. The finding of a genetic mutation could have far-reaching consequences for pharmaceutical therapy, personalized prevention strategies, and cascade testing. According to the National Comprehensive Cancer Network's (NCCN) and the Italian Association of Medical Oncology (AIOM) guidelines, unaffected family members should be tested only if the affected one is unavailable. This article explores whether germline genetic testing may be offered to high-risk families for hereditary cancer even if a living affected relative is missing. A retrospective study was carried out on 103 healthy subjects tested from 2017 to 2023. We enrolled all subjects with at least two first- or second-degree relatives affected by breast, ovarian, pancreatic, gastric, prostate, or colorectal cancer. All subjects were tested by Next Generation Sequencing (NGS) multi-gene panel of 27 cancer-associated genes. In the study population, 5 (about 5%) pathogenic/likely pathogenic variants (PVs/LPVs) were found, while 40 (42%) had a Variant of Uncertain Significance (VUS). This study highlights the importance of genetic testing for individuals with a strong family history of hereditary malignancies. This approach would allow women who tested positive to receive tailored treatment and prevention strategies based on their personal mutation status. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Uniportal Video-Assisted Thoracoscopic Surgery Completion Lobectomy Long after Wedge Resection or Segmentectomy in the Same Lobe: A Bicenter Study

Author

Meacci, Elisa, primary, Refai, Majed, additional, Nachira, Dania, additional, Salati, Michele, additional, Kuzmych, Khrystyna, additional, Tabacco, Diomira, additional, Zanfrini, Edoardo, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Congedo, Maria Teresa, additional, Chiappetta, Marco, additional, Petracca-Ciavarella, Leonardo, additional, Sassorossi, Carolina, additional, Andolfi, Marco, additional, Xiumè, Francesco, additional, Tiberi, Michela, additional, Guiducci, Gian Marco, additional, Vita, Maria Letizia, additional, Roncon, Alberto, additional, Nanto, Anna Chiara, additional, and Margaritora, Stefano, additional

Published
2024
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21. Prognostic Factors of Non-Predominant-Lepidic Lung Adenocarcinoma Presenting as Ground Glass Opacity: Results of a Multicenter Study

Author

Messa, Fabiana, primary, Siciliani, Alessandra, additional, Piccioni, Giorgia, additional, Leonardi, Beatrice, additional, Ciccone, Anna Maria, additional, D’Andrilli, Antonio, additional, Andreetti, Claudio, additional, Menna, Cecilia, additional, Vanni, Camilla, additional, Baccarini, Alberto Emiliano, additional, Tiracorrendo, Matteo, additional, Mancini, Massimiliano, additional, Vecchione, Andrea, additional, Nocera, Adriana, additional, Calabrese, Giuseppe, additional, Meacci, Elisa, additional, Margaritora, Stefano, additional, Natale, Giovanni, additional, Fiorelli, Alfonso, additional, Venuta, Federico, additional, Rendina, Erino Angelo, additional, Maurizi, Giulio, additional, and Ibrahim, Mohsen, additional

Published
2024
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22. The Efficacy of Continuous Serratus Anterior and Erector Spinae Plane Blocks vs Intercostal Nerve Block in Uniportal-Vats Surgery: A Propensity-Matched Prospective Trial

Author

Nachira, Dania, primary, Punzo, Giovanni, additional, Calabrese, Giuseppe, additional, Sessa, Flaminio, additional, Congedo, Maria Teresa, additional, Beccia, Giovanna, additional, Aceto, Paola, additional, Kuzmych, Khrystyna, additional, Cambise, Chiara, additional, Sassorossi, Carolina, additional, Nocera, Adriana, additional, Senatore, Alessia, additional, Vita, Maria Letizia, additional, Meacci, Elisa, additional, Sollazzi, Liliana, additional, and Margaritora, Stefano, additional

Published
2024
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23. Are the Efficacy and Safety of Chest Tubes in Uniportal Video-Assisted Thoracic Surgery Related to the Level of Intercostal Space Insertion or to the Drain Type? A Prospective Multicenter Study

Author

Nachira, Dania, primary, Bertoglio, Pietro, additional, Ismail, Mahmoud, additional, Napolitano, Antonio Giulio, additional, Calabrese, Giuseppe, additional, Kuzmych, Khrystyna, additional, Congedo, Maria Teresa, additional, Sassorossi, Carolina, additional, Meacci, Elisa, additional, Petracca Ciavarella, Leonardo, additional, Chiappetta, Marco, additional, Lococo, Filippo, additional, Solli, Piergiorgio, additional, and Margaritora, Stefano, additional

Published
2024
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24. The Role of Human Papilloma Virus (HPV) in Primary Lung Cancer Development: State of the Art and Future Perspectives

Author

Nachira, Dania, primary, Congedo, Maria Teresa, additional, D’Argento, Ettore, additional, Meacci, Elisa, additional, Evangelista, Jessica, additional, Sassorossi, Carolina, additional, Calabrese, Giuseppe, additional, Nocera, Adriana, additional, Kuzmych, Khrystyna, additional, Santangelo, Rosaria, additional, Rindi, Guido, additional, and Margaritora, Stefano, additional

Published
2024
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25. The genetic susceptibility in the development of malignant pleural mesothelioma: somatic and germline variants, clinicopathological features and implication in practical medical/surgical care: a narrative review

Author

Congedo, Maria Teresa, primary, West, Elizabeth Casey, additional, Evangelista, Jessica, additional, Mattingly, Aubrey Anne, additional, Calabrese, Giuseppe, additional, Sassorossi, Carolina, additional, Nocera, Adriana, additional, Chiappetta, Marco, additional, Flamini, Sara, additional, Abenavoli, Ludovico, additional, Margaritora, Stefano, additional, Boccuto, Luigi, additional, and Lococo, Filippo, additional

Published
2024
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32. In-Situ vs. Prefab 3D Printing Considerations for CO2- free Pop-up Architecture.

Author

Aslaminezhad, Atousa, Hidding, Arwin, Bier, Henriette, and Calabrese, Giuseppe

Subjects
THREE-dimensional printing, CARBON dioxide, HUMAN-robot interaction, SUSTAINABLE development, ENERGY consumption
Abstract

This paper revisits existing pop-up typologies in architecture to identify opportunities for new shelter models to address current housing demands and future habitation requirements on Mars. It presents advancements in design to production methodologies based on computational and robotic techniques to meet current requirements and affordances while integrating sustainable and adaptive functionalities. The main goal is to advance pop-up architecture by developing methods and technologies for rapidly deployable on- and off-Earth habitats while addressing challenges of carbon-free architecture by means of 3D printing. By reviewing state-of-the-art in-situ vs. prefab 3D printing approaches with a particular focus on Human-Robot Interaction (HRI) supported Design-to-Robotic-Production-Assembly and -Operation (D2RPA&O) methods developed at TU Delft material, process, and energy efficiency using locally sourced materials is achieved. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Daratumumab‐based induction and autologous transplantation in concomitant multiple myeloma and chronic myeloid leukemia

Author

Liberatore, Carmine, primary, Fioritoni, Francesca, additional, Natale, Annalisa, additional, Montanaro, Guido, additional, La Barba, Gaetano, additional, Passeri, Cecilia, additional, Iuliani, Ornella, additional, Fabi, Bianca, additional, Baldoni, Stefano, additional, Fantasia, Donatella, additional, Calabrese, Giuseppe, additional, Accorsi, Patrizia, additional, Santarone, Stella, additional, Pulini, Stefano, additional, and Di Ianni, Mauro, additional

Published
2023
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35. Surgical Resection of Pulmonary Metastases from Melanoma in Oligometastatic Patients: Results from a Multicentric Study in the Era of Immunoncology and Targeted Therapy

Author

Meacci, Elisa, primary, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Ibrahim, Mohsen, additional, Pariscenti, Gianluca, additional, Petrella, Francesco, additional, Casiraghi, Monica, additional, De Stefani, Alessandro, additional, del Regno, Laura del, additional, Peris, Ketty, additional, Triumbari, Elizabeth Katherine Anna, additional, Schinzari, Giovanni, additional, Rossi, Ernesto, additional, Petracca-Ciavarella, Leonardo, additional, Vita, Maria Letizia, additional, Chiappetta, Marco, additional, Siciliani, Alessandra, additional, Peritore, Valentina, additional, Manitto, Mattia, additional, Morelli, Lucia, additional, Zanfrini, Edoardo, additional, Tabacco, Diomira, additional, Calabrese, Giuseppe, additional, Bardoni, Claudia, additional, Evangelista, Jessica, additional, Spaggiari, Lorenzo, additional, and Margaritora, Stefano, additional

Published
2023
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36. Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study

Author

Sassorossi, Carolina, primary, Congedo, Maria Teresa, additional, Nachira, Dania, additional, Tabacco, Diomira, additional, Chiappetta, Marco, additional, Evangelista, Jessica, additional, di Gioia, Adele, additional, Di Resta, Velia, additional, Sorino, Claudio, additional, Mondoni, Michele, additional, Leoncini, Fausto, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Nocera, Adriana, additional, Lococo, Achille, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2023
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37. Uniportal-VATS vs. open McKeown esophagectomy: Surgical and long-term oncological outcomes

Author

Nachira, D., Congedo, Maria Teresa, Calabrese, Giuseppe, Tabacco, Diomira, Petracca Ciavarella, Leonardo, Meacci, Elisa, Vita, Maria Letizia, Punzo, Giovanni, Lococo, Filippo, Raveglia, F., Chiappetta, M., Porziella, Venanzio, Guttadauro, A., Cioffi, U., Margaritora, Stefano, Congedo M. T., Calabrese G., Tabacco D., Petracca Ciavarella L., Meacci E. (ORCID:0000-0001-8424-3816), Vita M. L., Punzo G., Lococo F. (ORCID:0000-0002-9383-5554), Porziella V. (ORCID:0000-0001-6000-3172), Margaritora S. (ORCID:0000-0002-9796-760X), Nachira, D., Congedo, Maria Teresa, Calabrese, Giuseppe, Tabacco, Diomira, Petracca Ciavarella, Leonardo, Meacci, Elisa, Vita, Maria Letizia, Punzo, Giovanni, Lococo, Filippo, Raveglia, F., Chiappetta, M., Porziella, Venanzio, Guttadauro, A., Cioffi, U., Margaritora, Stefano, Congedo M. T., Calabrese G., Tabacco D., Petracca Ciavarella L., Meacci E. (ORCID:0000-0001-8424-3816), Vita M. L., Punzo G., Lococo F. (ORCID:0000-0002-9383-5554), Porziella V. (ORCID:0000-0001-6000-3172), and Margaritora S. (ORCID:0000-0002-9796-760X)

Abstract

Background: Till now there are very few reports about surgical results of Uniportal-VATS esophagectomy and no one about long-term outcomes. This study is the first comparing surgical and oncological outcomes of Uniportal-VATS with open McKeown esophagectomy, with the largest reported series and longest oncological follow-up. Methods: The prospectively collected clinical, surgical and oncological data of 75 patients, undergone McKeown esophagectomy at our Thoracic Surgery Department, from January 2012 to August 2022, were retrospectively analyzed. Nineteen patients underwent esophagectomy by thoracotomy and reconstruction according to McKeown technique while 56 by Uniportal-VATS approach. Gastric tubulization was performed totally laparoscopic or through a mini-laparatomic access and cervical anastomosis was made according to Orringer's technique. Results: The mean operative thoracic time was similar in both accesses (102.34 ± 15.21 min in Uniportal-VATS vs. 115.56 ± 23.12 min in open, p: 0.646), with a comparable number of mediastinal nodes retrieved (Uniportal-VATS:13.40 ± 8.12 vs. open:15.00 ± 6.86, p: 0.275). No case needed conversion from VATS to open. The learning curve in Uniportal-VATS was completed after 34 cases, while the Mastery was reached after 40. Both approaches were comparable in terms of minor post-operative complications (like pneumonia, lung atelectasis, anemization, atrial fibrillation, anastomotic-leak, left vocal cord palsy, chylothorax), while the number of re-operation for major complications (bleeding or mediastinitis) was higher in open group (21.0% vs. 3.6%, p: 0.04). Both techniques were also effective in terms of surgical radicality and local recurrence but VATS approach allowed a significantly lower chest tube length (11.89 ± 9.55 vs. 25.82 ± 24.37 days, p: 0.003) and post-operative stay (15.63 ± 11.69 vs. 25.53 ± 23.33, p: 0.018). The 30-day mortality for complications related to surgery was higher in open group (p: 0.002). The 2-, 5

Published
2023

38. Surgical Resection of Pulmonary Metastases from Melanoma in Oligometastatic Patients: Results from a Multicentric Study in the Era of Immunoncology and Targeted Therapy

Author

Meacci, Elisa, Nachira, Dania, Congedo, Maria Teresa, Ibrahim, M., Pariscenti, G., Petrella, F., Casiraghi, M., De Stefani, A., del Regno, L., Peris, Ketty, Triumbari, E. K. A., Schinzari, Giovanni, Rossi, E., Petracca-Ciavarella, L., Vita, Maria Letizia, Chiappetta, M., Siciliani, A., Peritore, V., Manitto, M., Morelli, L., Zanfrini, E., Tabacco, Diomira, Calabrese, Giuseppe, Bardoni, C., Evangelista, Jessica, Spaggiari, L., Margaritora, Stefano, Meacci E. (ORCID:0000-0001-8424-3816), Nachira D. (ORCID:0000-0003-2937-9678), Congedo M. T., Peris K. (ORCID:0000-0002-5237-0463), Schinzari G. (ORCID:0000-0001-6105-7252), Vita M. L., Tabacco D., Calabrese G., Evangelista J., Margaritora S. (ORCID:0000-0002-9796-760X), Meacci, Elisa, Nachira, Dania, Congedo, Maria Teresa, Ibrahim, M., Pariscenti, G., Petrella, F., Casiraghi, M., De Stefani, A., del Regno, L., Peris, Ketty, Triumbari, E. K. A., Schinzari, Giovanni, Rossi, E., Petracca-Ciavarella, L., Vita, Maria Letizia, Chiappetta, M., Siciliani, A., Peritore, V., Manitto, M., Morelli, L., Zanfrini, E., Tabacco, Diomira, Calabrese, Giuseppe, Bardoni, C., Evangelista, Jessica, Spaggiari, L., Margaritora, Stefano, Meacci E. (ORCID:0000-0001-8424-3816), Nachira D. (ORCID:0000-0003-2937-9678), Congedo M. T., Peris K. (ORCID:0000-0002-5237-0463), Schinzari G. (ORCID:0000-0001-6105-7252), Vita M. L., Tabacco D., Calabrese G., Evangelista J., and Margaritora S. (ORCID:0000-0002-9796-760X)

Abstract

In the last decade, the emergence of effective systemic therapies (ESTs) in the form of both targeted and immuno-based therapies has revolutionized the treatment of patients with advanced stage III and stage IV melanoma. Even though lungs represent the most frequent site of melanoma metastases, only limited data are available on the role of surgery in isolated pulmonary metastases from malignant melanoma (PmMM) in the era of ESTs. The aim of this study is to describe the outcomes of patients who underwent metastasectomy of PmMM in the era of ESTs, in order to identify prognostic factors affecting survival and to provide a framework for more informed patient selection of treatmeant with lung surgery in the future. Clinical data of 183 patients who underwent metastasectomy of PmMM between June 2008 and June 2021 were collected among four Italian Thoracic Centers. The main clinical, surgical and oncological variables reviewed were: sex, comorbidities, previous oncological history, melanoma histotypes and primary site, date of primary cancer surgical treatment, melanoma growth phase, Breslow thickness, mutation pattern disease, stage at diagnosis, metastatic sites, DFI (Disease Free Interval), characteristics of lung metastases (number, side, dimension, type of resection), adjuvant therapy after lung metastasectomy, site of recurrence, disease-free survival (DFS) and cancer-specific survival (CSS; defined as the time interval between the first melanoma resection or lung metastasectomy and death from cancer). All patients underwent surgical resection of the primary melanoma before lung metastasectomy. Twenty-six (14.2%) patients already had a synchronous lung metastasis at the time of primary melanoma diagnosis. A wedge resection was performed in 95.6% of cases to radically remove the pulmonary localizations, while an anatomical resection was necessary in the remaining cases. The incidence of major post-operative complications was null, while only 21 patients (11.5%) dev

Published
2023

39. Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study

Author

Sassorossi, Carolina, Congedo, Maria Teresa, Nachira, Dania, Tabacco, Diomira, Chiappetta, M., Evangelista, Jessica, di Gioia, A., Di Resta, V., Sorino, C., Mondoni, M., Leoncini, F., Calabrese, Giuseppe, Napolitano, A. G., Nocera, Adriana, Lococo, A., Margaritora, Stefano, Lococo, Filippo, Sassorossi C., Congedo M. T., Nachira D. (ORCID:0000-0003-2937-9678), Tabacco D., Evangelista J., Calabrese G., Nocera A., Margaritora S. (ORCID:0000-0002-9796-760X), Lococo F. (ORCID:0000-0002-9383-5554), Sassorossi, Carolina, Congedo, Maria Teresa, Nachira, Dania, Tabacco, Diomira, Chiappetta, M., Evangelista, Jessica, di Gioia, A., Di Resta, V., Sorino, C., Mondoni, M., Leoncini, F., Calabrese, Giuseppe, Napolitano, A. G., Nocera, Adriana, Lococo, A., Margaritora, Stefano, Lococo, Filippo, Sassorossi C., Congedo M. T., Nachira D. (ORCID:0000-0003-2937-9678), Tabacco D., Evangelista J., Calabrese G., Nocera A., Margaritora S. (ORCID:0000-0002-9796-760X), and Lococo F. (ORCID:0000-0002-9383-5554)

Abstract

Alveolo-pleural fistula remains a serious post-operative complication in lung cancer patients after surgery, which is associated with prolonged hospital stay and higher healthcare costs. The aim of this study is to evaluate the efficacy of a polyglycol acid (PGA)-sheet known as Neoveil in preventing post-operative air-leak in cases of detected intra-operative air-leak after lung resection. Between 11/2021 and 7/2022, a total of 329 non-small cell lung cancer (NSCLC) patients were surgically treated in two institutions. Major lung resections were performed in 251 cases. Among them, 44 patients with significant intra-operative air-leak at surgery were treated by reinforcing staple lines with Neoveil (study group). On the other hand, a historical group (selected by propensity score matched analysis) consisting of 44 lung cancer patients with significant intra-operative air leak treated by methods other than the application of sealant patches were considered as the control group. The presence of prolonged air-leak (primary endpoint), pleural drainage duration, hospital stay, and post-operative complication rates were evaluated. The results showed that prolonged air-leak (>5 days after surgery) was not observed in study group, while this event occurred in four patients (9.1%) in the control group. Additionally, a substantial reduction (despite not statistically significant) in the chest tube removal was noted in the study group with respect to the control group (3.5 vs. 4.5, p = 0.189). In addition, a significant decrease in hospital stay (4 vs. 6 days, p = 0.045) and a reduction in post-operative complications (2 vs. 10, p = 0.015) were observed in the study group when compared with the control group. Therefore, in cases associated with intra-operative air-leak after major lung resection, Neoveil was considered a safer and more effective aerostatic tool and represents a viable option during surgical procedures.

Published
2023

42. Uniportal-VATS vs. open McKeown esophagectomy: Surgical and long-term oncological outcomes

Author

Nachira, Dania, primary, Congedo, Maria Teresa, additional, Calabrese, Giuseppe, additional, Tabacco, Diomira, additional, Petracca Ciavarella, Leonardo, additional, Meacci, Elisa, additional, Vita, Maria Letizia, additional, Punzo, Giovanni, additional, Lococo, Filippo, additional, Raveglia, Federico, additional, Chiappetta, Marco, additional, Porziella, Venanzio, additional, Guttadauro, Angelo, additional, Cioffi, Ugo, additional, and Margaritora, Stefano, additional

Published
2023
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46. Professionalization and Dissemination Processes for Project Management Practices: A Situationist Perspective

Author

Calabrese, Giuseppe, Di Nauta, Primiano, Spagnoletti, Paolo, Series editor, De Marco, Marco, Series editor, Pouloudi, Nancy, Series editor, Te'eni, Dov, Series editor, vom Brock, Jan, Series editor, Winter, Robert, Series editor, Baskerville, Richard, Series editor, Baglieri, Daniela, editor, Metallo, Concetta, editor, Rossignoli, Cecilia, editor, and Pezzillo Iacono, Mario, editor

Published
2014
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48. Risk Factors Associated with Post-Operative Complications in Multidisciplinary Treatment of Descending Necrotizing Mediastinitis

Author

Congedo, Maria Teresa, primary, Nachira, Dania, additional, Pennisi, Mariano Alberto, additional, Chiappetta, Marco, additional, Calabrese, Giuseppe, additional, Bello, Giuseppe, additional, Parrilla, Claudio, additional, Franza, Laura, additional, Covino, Marcello, additional, Petracca Ciavarella, Leonardo, additional, Porziella, Venanzio, additional, Vita, Maria Letizia, additional, Lococo, Filippo, additional, Margaritora, Stefano, additional, and Meacci, Elisa, additional

Published
2022
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