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Your search keyword '"Caivano, Grazia"' showing total 10 results
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10 results on '"Caivano, Grazia"'

3. Selecting Appropriate Excipients for Paediatric Dosage Form - Paediatric Excipients Risk Assessment (Pera) Framework – Part 1

Author

Salunke, Smita, primary, Agrawal, Anjali, additional, Walsh, Jennifer, additional, Nunn, Anthony, additional, Hughes, Kevin, additional, Kuehl, Peter, additional, Caivano, Grazia, additional, Clapham, David, additional, Thompson, Karen, additional, Rumondor, Alfred, additional, Enright, Brian, additional, and Sheratt, Philip, additional

Published
2024
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4. Differential Performance and Lung Deposition of Levofloxacin with Different Nebulisers Used in Cystic Fibrosis

Author

Schwarz, Carsten, primary, Procaccianti, Claudio, additional, Costa, Laura, additional, Brini, Riccardo, additional, Friend, Richard, additional, Caivano, Grazia, additional, Sadafi, Hosein, additional, Mussche, Charles, additional, Schwenck, Nicolas, additional, Hahn, Michael, additional, Murgia, Xabier, additional, and Bianco, Federico, additional

Published
2022
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5. A consensus research agenda for optimising nasal drug delivery

Author

Forbes, Ben, Bommer, Rene, Goole, Jonathan, Hellfritzsch, Marie, De Kruijf, Wilbur, Lambert, Pierre, Caivano, Grazia, Regard, Alain, Schiaretti, Francesca, Trenkel, Marie, Vecellio, Laurent, Williams, Gerallt, Sonvico, Fabio, Scherließ, Regina, Forbes, Ben, Bommer, Rene, Goole, Jonathan, Hellfritzsch, Marie, De Kruijf, Wilbur, Lambert, Pierre, Caivano, Grazia, Regard, Alain, Schiaretti, Francesca, Trenkel, Marie, Vecellio, Laurent, Williams, Gerallt, Sonvico, Fabio, and Scherließ, Regina

Abstract

Nasal drug delivery has specific challenges which are distinct from oral inhalation, alongside which it is often considered. The next generation of nasal products will be required to deliver new classes of molecule, e.g. vaccines, biologics and drugs with action in the brain or sinuses, to local and systemic therapeutic targets. Innovations and new tools/knowledge are required to design products to deliver these therapeutic agents to the right target at the right time in the right patients. We report the outcomes of an expert meeting convened to consider gaps in knowledge and unmet research needs in terms of (i) formulation and devices, (ii) meaningful product characterization and modeling, (iii) opportunities to modify absorption and clearance. Important research questions were identified in the areas of device and formulation innovation, critical quality attributes for different nasal products, development of nasal casts for drug deposition studies, improved experimental models, the use of simulations and nasal delivery in special populations. We offer these questions as a stimulus to research and suggest that they might be addressed most effectively by collaborative research endeavors., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

7. A consensus research agenda for optimising nasal drug delivery

Author

Forbes, Ben, primary, Bommer, Rene, additional, Goole, Jonathan, additional, Hellfritzsch, Marie, additional, De Kruijf, Wilbur, additional, Lambert, Pierre, additional, Caivano, Grazia, additional, Regard, Alain, additional, Schiaretti, Francesca, additional, Trenkel, Marie, additional, Vecellio, Laurent, additional, Williams, Gerallt, additional, Sonvico, Fabio, additional, and Scherließ, Regina, additional

Published
2020
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10. Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine.

Author

O'Brien, Fiona, Clapham, David, Krysiak, Kamelia, Batchelor, Hannah, Field, Peter, Caivano, Grazia, Pertile, Marisa, Nunn, Anthony, and Tuleu, Catherine

Subjects
PREMATURE infants, MEDICATION errors, DRUG administration, DRUG dosage, INFANTS, NEWBORN infants
Abstract

The development of age-appropriate formulations should focus on dosage forms that can deliver variable yet accurate doses that are safe and acceptable to the child, are matched to his/her development and ability, and avoid medication errors. However, in the past decade, the medication needs of neonates have largely been neglected. The aim of this review is to expand on what differentiates the needs of preterm and term neonates from those of the older paediatric subsets, in terms of environment of care, ability to measure and administer the dose (from the perspective of the patient and carer, the routes of administration, the device and the product), neonatal biopharmaceutics and regulatory challenges. This review offers insight into those challenges posed by the formulation of medicinal products for neonatal patients in order to support the development of clinically relevant products. [ABSTRACT FROM AUTHOR]

Published
2019
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