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27 results on '"Cairat, Manon"'

1. Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study

Author

Castro-Espin, Carlota, Cairat, Manon, Navionis, Anne-Sophie, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Mellemkjær, Lene, Mancini, Francesca Romana, Hajji-Louati, Mariem, Severi, Gianluca, Le Cornet, Charlotte, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Sacerdote, Carlotta, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Smith-Byrne, Karl, Heath, Alicia K., Christakoudi, Sofia, Gunter, Marc J., Rinaldi, Sabina, Agudo, Antonio, and Dossus, Laure

Published
2024
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2. Degree of food processing and breast cancer risk: a prospective study in 9 European countries

Author

Cairat, Manon, Yammine, Sahar, Fiolet, Thibault, Fournier, Agnès, Boutron-Ruault, Marie-Christine, Laouali, Nasser, Mancini, Francesca Romana, Severi, Gianluca, Berstein, Fernanda Morales, Rauber, Fernanda, Levy, Renata Bertazzi, Skeie, Guri, Borch, Kristin Benjaminsen, Tjønneland, Anne, Mellemkjær, Lene, Borné, Yan, Rosendahl, Ann H., Masala, Giovanna, Giraudo, Maria Teresa, de Magistris, Maria Santucci, Katzke, Verena, Bajracharya, Rashmita, Santiuste, Carmen, Amiano, Pilar, Bodén, Stina, Castro-Espin, Carlota, Sánchez, Maria-Jose, Touvier, Mathilde, Deschasaux-Tanguy, Mélanie, Srour, Bernard, Schulze, Matthias B., Guevara, Marcela, Kliemann, Nathalie, Lopez, Jessica Blanco, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter P., Millett, Christopher, Riboli, Elio, Heath, Alicia K., Biessy, Carine, Viallon, Vivian, Casagrande, Corinne, Nicolas, Genevieve, Gunter, Marc J., and Huybrechts, Inge

Published
2024
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3. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

Author

Morales-Berstein, Fernanda, Biessy, Carine, Viallon, Vivian, Goncalves-Soares, Ana, Casagrande, Corinne, Hémon, Bertrand, Kliemann, Nathalie, Cairat, Manon, Blanco Lopez, Jessica, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter, Rauber, Fernanda, Bertazzi Levy, Renata, Barbosa Cunha, Diana, Jakszyn, Paula, Ferrari, Pietro, Vineis, Paolo, Masala, Giovanna, Catalano, Alberto, Sonestedt, Emily, Borné, Yan, Katzke, Verena, Bajracharya, Rashmita, Agnoli, Claudia, Guevara, Marcela, Heath, Alicia, Radoï, Loredana, Mancini, Francesca, Weiderpass, Elisabete, Huerta, José María, Sánchez, María-José, Tjønneland, Anne, Kyrø, Cecilie, Schulze, Matthias B., Skeie, Guri, Lukic, Marko, Braaten, Tonje, Gunter, Marc, Millett, Christopher, Agudo, Antonio, Brennan, Paul, Borges, M. Carolina, Richmond, Rebecca C., Richardson, Tom G., Davey Smith, George, Relton, Caroline L., and Huybrechts, Inge

Published
2024
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6. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Author

Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure

Published
2022
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7. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries

Author

Fiolet, Thibault, Casagrande, Corinne, Nicolas, Geneviève, Horvath, Zsuzsanna, Frenoy, Pauline, Weiderpass, Elisabete, Katzke, Verena, Kaaks, Rudolf, Rodriguez-Barranco, Miguel, Panico, Salvatore, Sacerdote, Carlotta, Manjer, Jonas, Sonestedt, Emily, Grioni, Sara, Agudo, Antonio, Rylander, Charlotta, Haugdahl Nøst, Therese, Skeie, Guri, Tjønneland, Anne, Raaschou-Nielsen, Ole, Ardanaz, Eva, Amiano, Pilar, Dolores Chirlaque López, María, Schulze, Matthias B., Wennberg, Maria, Harlid, Sophia, Cairat, Manon, Kvaskoff, Marina, Huybrechts, Inge, and Romana Mancini, Francesca

Published
2022
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9. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study:a mediation analysis

Author

Morales-Berstein, Fernanda, Biessy, Carine, Viallon, Vivian, Goncalves-Soares, Ana, Casagrande, Corinne, Hémon, Bertrand, Kliemann, Nathalie, Cairat, Manon, Blanco Lopez, Jessica, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter, Rauber, Fernanda, Bertazzi Levy, Renata, Barbosa Cunha, Diana, Jakszyn, Paula, Ferrari, Pietro, Vineis, Paolo, Masala, Giovanna, Catalano, Alberto, Sonestedt, Emily, Borné, Yan, Katzke, Verena, Bajracharya, Rashmita, Agnoli, Claudia, Guevara, Marcela, Heath, Alicia, Radoï, Loredana, Mancini, Francesca, Weiderpass, Elisabete, Huerta, José María, Sánchez, María-José, Tjønneland, Anne, Kyrø, Cecilie, Schulze, Matthias B, Skeie, Guri, Lukic, Marko, Braaten, Tonje, Gunter, Marc, Millett, Christopher, Agudo, Antonio, Brennan, Paul, Borges, M Carolina, Richmond, Rebecca C, Richardson, Tom G, Davey Smith, George, Relton, Caroline L, Huybrechts, Inge, Morales-Berstein, Fernanda, Biessy, Carine, Viallon, Vivian, Goncalves-Soares, Ana, Casagrande, Corinne, Hémon, Bertrand, Kliemann, Nathalie, Cairat, Manon, Blanco Lopez, Jessica, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter, Rauber, Fernanda, Bertazzi Levy, Renata, Barbosa Cunha, Diana, Jakszyn, Paula, Ferrari, Pietro, Vineis, Paolo, Masala, Giovanna, Catalano, Alberto, Sonestedt, Emily, Borné, Yan, Katzke, Verena, Bajracharya, Rashmita, Agnoli, Claudia, Guevara, Marcela, Heath, Alicia, Radoï, Loredana, Mancini, Francesca, Weiderpass, Elisabete, Huerta, José María, Sánchez, María-José, Tjønneland, Anne, Kyrø, Cecilie, Schulze, Matthias B, Skeie, Guri, Lukic, Marko, Braaten, Tonje, Gunter, Marc, Millett, Christopher, Agudo, Antonio, Brennan, Paul, Borges, M Carolina, Richmond, Rebecca C, Richardson, Tom G, Davey Smith, George, Relton, Caroline L, and Huybrechts, Inge

Abstract

Objectives The risk of suicidal behavior after discharge from psychiatric admission is high. The aim of this study was to examine whether the SAFE intervention, an implementation of a systematic safer discharge procedure, was associated with a reduction in suicidal behavior after discharge. Methods The SAFE intervention was implemented at Mental Health Center Copenhagen in March 2018 and consisted of three systematic discharge procedures: (1) A face-to-face meeting between patient and outpatient staff prior to discharge, (2) A face-to-face meeting within the first week after discharge, and (3) Involvement of relatives. Risk of suicide attempt at six-month post-discharge among patients discharged from the SAFE intervention was compared with patients discharged from comparison mental health centers using propensity score matching. Results 7604 discharges took place at the intervention site, which were 1:1 matched with discharges from comparison sites. During the six months of follow-up, a total of 570 suicide attempts and 25 suicides occurred. The rate of suicide attempt was 11,652 per 100,000 person-years at the SAFE site, while it was 10,530 at comparisons sites. No observable difference in suicide attempt 1.10 (95% CI: 0.89–1.35) or death by suicide (OR = 1.27; 95% CI:0.58–2.81) was found between sites at 6-month follow-up. Conclusion No difference in suicidal behavior between the sites was found in this pragmatic study. High rates of suicidal behavior were found during the 6-months discharge period, which could suggest that a preventive intervention should include support over a longer post-discharge period than the one-week follow-up offered in the SAFE intervention., PURPOSE: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.RESULTS: During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.CONCLUSIONS: We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).

Published
2024

11. P13-030-23 Ultra-Processed Food Consumption, Adiposity and Upper-Aerodigestive Tract Cancer Risk in the European Prospective Investigation Into Cancer Study: A Mediation Analysis

Author

Berstein, Fernanda Morales, primary, Agudo, Antonio, additional, Nahas, Aline Al, additional, Cunha, Diana Barbosa, additional, Levy, Renata Bertazzi, additional, Biessy, Carine, additional, Lopez, Jessica Blanco, additional, Borges, Carolina, additional, Brennan, Paul, additional, Cairat, Manon, additional, Casagrande, Corinne, additional, Chang, Kiara, additional, Smith, George Davey, additional, Ferrari, Pietro, additional, Soares, Ana Goncalves, additional, Gunter, Marc, additional, Huybrechts, Inge, additional, Kliemann, Nathalie, additional, Millett, Christopher, additional, Rauber, Fernanda, additional, Relton, Caroline, additional, Richardson, Tom, additional, Richmond, Rebecca, additional, Vamos, Eszter, additional, Viallon, Vivian, additional, and Vineis, Paolo, additional

Published
2023
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17. Antiplatelet drugs and breast cancer risk in a large nationwide Danish case‐control study.

Author

Cairat, Manon, Pottegård, Anton, Olesen, Morten, Dossus, Laure, Fournier, Agnès, and Hicks, Blánaid

Subjects
PLATELET aggregation inhibitors, DISEASE risk factors, BREAST cancer, ANTINEOPLASTIC agents, CASE-control method
Abstract

Low‐dose aspirin has been hypothesized to prevent cancer risk by inhibiting platelet aggregation. However, the anti‐cancer effect of low‐dose aspirin has recently been questioned and its effect on breast cancer development remains unclear. The impact of other antiplatelet drugs on breast cancer risk has rarely been evaluated. Thus, this study aimed to investigate the associations between breast cancer risk and antiplatelet drug use in a nationwide nested case‐control study. From the Danish healthcare registries, we identified as cases all women with invasive breast cancer diagnosis between 2001 and 2018 (n = 68 852). The date of diagnosis corresponded to the index date. We matched cases to 10 population controls on age and calendar time, using risk set sampling. Controls were assigned the same index date as their matched case. We used the prescription registry to identify exposure to low‐dose aspirin, clopidogrel and dipyridamole. We defined ever use of antiplatelet drugs as at least two prescriptions filled up to 1 year before the index date. We applied conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals for breast cancer associated with the use of antiplatelet drugs, overall, by breast cancer subtype and by cumulative dose. Twelve percent of women had ever been exposed to low‐dose aspirin, 2% to clopidogrel and 2% to dipyridamole. In multivariable models, breast cancer risk was not associated with ever use of low‐dose aspirin (OR = 1.00 [0.97‐1.03]), clopidogrel (OR = 0.93 [0.87‐1.00]), and dipyridamole (OR = 1.02 [0.94‐1.10]), compared with never use, and there was no evidence of a dose‐response relation. However, we found an inverse association between dipyridamole use and breast cancer risk among women aged <55 years old, with suggestion of a dose‐response relationship (OR per 1000 Defined Daily Doses = 0.72 [0.54‐0.95]). Associations did not differ by breast cancer histological type, estrogen receptor status or clinical stage at diagnosis. Overall, the findings from this study do not support the use of antiplatelet drugs for breast cancer prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Additional file 1 of Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Author

Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure

Subjects
skin and connective tissue diseases
Abstract

Additional file 1: Circulating inflammatory biomarkers and breast cancer risk in the EPIC prospective study: Supplementary Tables S1- S7 and Figures S1-S3. Table S1. Geometric mean values for inflammatory biomarkers in breast cancer cases and matched controls. Table S2. Associations between inflammatory biomarkers and breast cancer risk by age at diagnosis. Table S3. Associations between inflammatory biomarkers and breast cancer risk by breast cancer molecular subtypes. Table S4. Associations between inflammatory biomarkers and breast cancer risk by time between blood collection and diagnosis. Table S5. Associations between inflammatory biomarkers and breast cancer risk by body mass index. Table S6. Associations between inflammatory biomarkers and breast cancer risk by waist circumference. Table S7. Associations between inflammatory biomarkers and breast cancer risk among non-hormone users at blood collection. Table S8. Associations between IL-10 and breast cancer risk overall and according to menopausal status at blood collection, after excluding women with values of IL-10 below the LOQ. Table S9. Associations between TNF-α and breast cancer risk overall and according to menopausal status at blood collection, after excluding women with values of TNF-α below the LOQ. Figure S1. Flow chart of the study population. Figure S2. Association between leptin and breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline). Figure S3. Association between leptin-to-adiponectin ratio and breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline). Figure S4. Association between CRP with breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline).

Published
2022
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19. Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Author

Castro-Espin, Carlota, primary, Agudo, Antonio, additional, Bonet, Catalina, additional, Katzke, Verena, additional, Turzanski-Fortner, Renée, additional, Aleksandrova, Krasimira, additional, Schulze, Matthias B., additional, Tjønneland, Anne, additional, Dahm, Christina C., additional, Quirós, José-Ramón, additional, Sánchez, María-José, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, May, Anne M., additional, Bodén, Stina, additional, Gram, Inger T., additional, Skeie, Guri, additional, Laouali, Nasser, additional, Shah, Sanam, additional, Severi, Gianluca, additional, Aune, Dagfinn, additional, Merritt, Melissa A., additional, Cairat, Manon, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Dossus, Laure, additional, and Jakszyn, Paula, additional

Published
2021
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20. Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Author

Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B., Tjønneland, Anne, Dahm, Christina C., Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M., Bodén, Stina, Gram, Inger T., Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A., Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, Jakszyn, Paula, Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B., Tjønneland, Anne, Dahm, Christina C., Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M., Bodén, Stina, Gram, Inger T., Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A., Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, and Jakszyn, Paula

Abstract

The role of chronic inflammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the inflammatory potential of the diet and risk of BC overall, according to menopausal status and tumour subtypes. Within the European Prospective Investigation into Cancer and Nutrition cohort, 318,686 women were followed for 14 years, among whom 13,246 incident BC cases were identified. The inflammatory potential of the diet was characterized by an inflammatory score of the diet (ISD). Multivariable Cox regression models were used to assess the potential effect of the ISD on BC risk by means of hazard ratios (HR) and 95% confidence intervals (CI). ISD was positively associated with BC risk. Each increase of one standard deviation (1-Sd) of the score increased by 4% the risk of BC (HR = 1.04; 95% CI 1.01–1.07). Women in the highest quintile of the ISD (indicating a most pro-inflammatory diet) had a 12% increase in risk compared with those in the lowest quintile (HR = 1.12; 95% CI 1.04–1.21) with a significant trend. The association was strongest among premenopausal women, with an 8% increased risk for 1-Sd increase in the score (HR = 1.08; 95% CI 1.01–1.14). The pattern of the association was quite homogeneous by BC subtypes based on hormone receptor status. There were no significant interactions between ISD and body mass index, physical activity, or alcohol consumption. Women consuming more pro-inflammatory diets as measured by ISD are at increased risk for BC, especially premenopausal women.

Published
2021
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21. Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Author

Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B, Tjønneland, Anne, Dahm, Christina C, Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M, Bodén, Stina, Gram, Inger T, Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A, Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, Jakszyn, Paula, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B, Tjønneland, Anne, Dahm, Christina C, Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M, Bodén, Stina, Gram, Inger T, Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A, Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, and Jakszyn, Paula

Published
2021

23. Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study

Author

Cairat, Manon, Fournier, Agnès, Murphy, Neil, Biessy, Carine, Scalbert, Augustin, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Arveux, Patrick, Boutron-Ruault, Marie Christine, Cadeau, Claire, Fortner, Renée Turzanski, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Peeters, Petra H.M., Van Gils, Carla H., Wareham, Nicholas J., Khaw, Kay Tee, Aune, Dagfinn, Riboli, Elio, Gunter, Marc J., Dossus, Laure, Cairat, Manon, Fournier, Agnès, Murphy, Neil, Biessy, Carine, Scalbert, Augustin, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Arveux, Patrick, Boutron-Ruault, Marie Christine, Cadeau, Claire, Fortner, Renée Turzanski, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Peeters, Petra H.M., Van Gils, Carla H., Wareham, Nicholas J., Khaw, Kay Tee, Aune, Dagfinn, Riboli, Elio, Gunter, Marc J., and Dossus, Laure

Published
2018

24. Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study

Author

Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Kanker, Cairat, Manon, Fournier, Agnès, Murphy, Neil, Biessy, Carine, Scalbert, Augustin, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Arveux, Patrick, Boutron-Ruault, Marie Christine, Cadeau, Claire, Fortner, Renée Turzanski, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Peeters, Petra H.M., Van Gils, Carla H., Wareham, Nicholas J., Khaw, Kay Tee, Aune, Dagfinn, Riboli, Elio, Gunter, Marc J., Dossus, Laure, Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Kanker, Cairat, Manon, Fournier, Agnès, Murphy, Neil, Biessy, Carine, Scalbert, Augustin, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Arveux, Patrick, Boutron-Ruault, Marie Christine, Cadeau, Claire, Fortner, Renée Turzanski, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Peeters, Petra H.M., Van Gils, Carla H., Wareham, Nicholas J., Khaw, Kay Tee, Aune, Dagfinn, Riboli, Elio, Gunter, Marc J., and Dossus, Laure

Published
2018

25. Nonsteroidal anti‐inflammatory drug use and breast cancer risk in a European prospective cohort study

Author

Cairat, Manon, primary, Fournier, Agnès, additional, Murphy, Neil, additional, Biessy, Carine, additional, Scalbert, Augustin, additional, Rinaldi, Sabina, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Arveux, Patrick, additional, Boutron‐Ruault, Marie‐Christine, additional, Cadeau, Claire, additional, Fortner, Renée Turzanski, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Aleksandrova, Krasimira, additional, Peeters, Petra H.M., additional, Van Gils, Carla H., additional, Wareham, Nicholas J., additional, Khaw, Kay‐Tee, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, Gunter, Marc J., additional, and Dossus, Laure, additional

Published
2018
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26. Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study

Author

Petra H.M. Peeters, Anja Olsen, Augustin Scalbert, Dagfinn Aune, Carla H. van Gils, Carine Biessy, Kim Overvad, Kay-Tee Khaw, Neil Murphy, Krasimira Aleksandrova, Elio Riboli, Claire Cadeau, Marie-Christine Boutron-Ruault, Heiner Boeing, Nicholas J. Wareham, Agnès Fournier, Anne Tjønneland, Manon Cairat, Laure Dossus, Renée T. Fortner, Sabina Rinaldi, Rudolf Kaaks, Marc J. Gunter, Patrick Arveux, Cairat, Manon [0000-0002-0964-3120], Murphy, Neil [0000-0003-3347-8249], Rinaldi, Sabina [0000-0002-6846-1204], and Apollo - University of Cambridge Repository

Subjects
Oncology, Adult, medicine.medical_specialty, Cancer Research, Breast Neoplasms, Article, REPLACEMENT THERAPY, ASPIRIN USE, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, cohort studies, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, chemoprevention, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, skin and connective tissue diseases, Aged, Science & Technology, business.industry, Proportional hazards model, Incidence, Hazard ratio, Anti-Inflammatory Agents, Non-Steroidal, Middle Aged, medicine.disease, Prognosis, European Prospective Investigation into Cancer and Nutrition, Europe, nonsteroidal anti-inflammatory agents, POSTMENOPAUSAL WOMEN, 030220 oncology & carcinogenesis, Hormonal therapy, Female, postmenopausal hormone replacement therapy, business, Life Sciences & Biomedicine, Cohort study, Follow-Up Studies
Abstract

Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to assess the association between NSAID use and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Self-reported information on NSAID use at baseline has been collected in five EPIC countries. Multivariable Cox regression models were used to estimate hazard ratios for the association of NSAID use with breast cancer incidence with adjustment for potential confounders. We also assessed effect modification by breast cancer risk factors and examined the associations within specific breast cancer subtypes. Among the 140,981 women included in the analysis, 7% were regularly using NSAIDs at baseline. During a median follow-up time period of 13 years, 7,379 incident breast cancer cases were diagnosed (816 in situ and 6,563 invasive). There were no statistically significant associations between NSAID use and breast cancer risk, overall and by subtypes. However, a statistically significant interaction was observed for invasive cases between NSAID use and ever use of menopausal hormonal therapy (MHT) among postmenopausal women [MHT users: HRNSAID use =0.84 (0.73 - 0.96); non MHT users: HRNSAID use = 1.08 (0.93 - 1.25); Pinteraction = 0.05]. Our results indicate potential effect modification of MHT use on the association between use of NSAIDs and breast cancer risk which deserves in-depth investigation in studies with accurate data on both NSAID and MHT use. This article is protected by copyright. All rights reserved.

Published
2018
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27. Use of menopausal hormone therapy and ovarian cancer risk in a French cohort study.

Author

Fournier A, Cairat M, Severi G, Gunter MJ, Rinaldi S, and Dossus L

Subjects
Humans, Female, Cohort Studies, Dydrogesterone, Prospective Studies, Postmenopause, Risk Factors, Progestins adverse effects, Estrogens adverse effects, Menopause, Progesterone adverse effects, Ovarian Neoplasms chemically induced, Ovarian Neoplasms epidemiology, Ovarian Neoplasms drug therapy
Abstract

Background: Epidemiological studies have found that menopausal hormone therapy (MHT) use is associated with an increased ovarian cancer risk. However, whether different MHT types confer the same level of risk is unclear. We estimated the associations between different MHT types and the risk of ovarian cancer in a prospective cohort., Methods: The study population included 75 606 postmenopausal women from the E3N cohort. Exposure to MHT was identified from self-reports in biennial questionnaires between 1992 and 2004 and from drug claim data matched to the cohort between 2004 and 2014. Hazard ratios and 95% confidence intervals (CIs) of ovarian cancer were estimated using multivariable Cox proportional hazards models with MHT as a time-varying exposure. Tests of statistical significance were 2-sided., Results: Over an average 15.3 years follow-up, 416 ovarian cancers were diagnosed. Hazard ratios of ovarian cancer associated with ever use of estrogens combined with progesterone or dydrogesterone and ever use of estrogens combined with other progestagen were equal to 1.28 (95% CI = 1.04 to 1.57) and 0.81 (95% CI = 0.65 to 1.00), respectively (Phomogeneity = .003), compared with never use. The hazard ratio for unopposed estrogen use was 1.09 (95% CI = 0.82 to 1.46). We found no trend according to duration of use or time since last use except for estrogens combined with progesterone or dydrogesterone, which showed decreasing risk with increasing time since last use., Conclusion: Different MHT types may impact ovarian cancer risk differentially. The possibility that MHT containing progestagens other than progesterone or dydrogesterone may confer some protection should be evaluated in other epidemiological studies., (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2023
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