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541 results on '"Caira M"'

1. Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria parasitemia.

Author

Virginie Rougeron, Caira M Woods, Kathryn E Tiedje, Florence Bodeau-Livinec, Florence Migot-Nabias, Philippe Deloron, Adrian J F Luty, Freya J I Fowkes, and Karen P Day

Subjects
Medicine, Science
Abstract

Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglycerides. The APOE gene encodes 3 isoforms Ɛ4, Ɛ3 and Ɛ2 with APOE Ɛ4 associated with higher plasma cholesterol levels and increased pathogenesis in several infectious diseases (HIV, HSV). Given that cholesterol is an important nutrient for malaria parasites, we examined whether APOE Ɛ4 was a risk factor for Plasmodium infection, in terms of prevalence or parasite density. A cross sectional survey was performed in 508 children aged 1 to 12 years in Gabon during the wet season. Children were screened for Plasmodium spp. infection, APOE and hemoglobin S (HbS) polymorphisms. Median parasite densities were significantly higher in APOE Ɛ4 children for Plasmodium spp. densities compared to non-APOE Ɛ4 children. When stratified for HbS polymorphisms, median Plasmodium spp. densities were significantly higher in HbAA children if they had an APOE Ɛ4 allele compared to those without an APOE Ɛ4 allele. When considering non-APOE Ɛ4 children, there was no quantitative reduction of Plasmodium spp. parasite densities for HbAS compared to HbAA phenotypes. No influence of APOE Ɛ4 on successful Plasmodium liver cell invasion was detected by multiplicity of infection. These results show that the APOE Ɛ4 allele is associated with higher median malaria parasite densities in children likely due to the importance of cholesterol availability to parasite growth and replication. Results suggest an epistatic interaction between APOE and HbS genes such that sickle cell trait only had an effect on parasite density in APOE Ɛ4 children. This suggests a linked pathway of regulation of parasite density involving expression of these genes. These findings have significance for understanding host determinants of regulation of malaria parasite density, the design of clinical trials as well as studies of co-infection with Plasmodium and other pathogens.

Published
2013
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3. Assessing eligibility for treatment in acute myeloid leukemia in 2023

Author

Venditti, A, Cairoli, R, Caira, M, Finsinger, P, Finocchiaro, F, Neri, B, De Benedittis, D, Rossi, G, Ferrara, F, Venditti, Adriano, Cairoli, Roberto, Caira, Morena, Finsinger, Paola, Finocchiaro, Fabio, Neri, Benedetta, De Benedittis, Daniela, Rossi, Giuseppe, Ferrara, Felicetto, Venditti, A, Cairoli, R, Caira, M, Finsinger, P, Finocchiaro, F, Neri, B, De Benedittis, D, Rossi, G, Ferrara, F, Venditti, Adriano, Cairoli, Roberto, Caira, Morena, Finsinger, Paola, Finocchiaro, Fabio, Neri, Benedetta, De Benedittis, Daniela, Rossi, Giuseppe, and Ferrara, Felicetto

Abstract

Introduction: Age has historically been considered the main criterion to determine eligibility for intensive chemotherapy in patients with acute myeloid leukemia (AML), but age alone can no longer be considered an absolute indicator in determining which patients should be defined as unfit. Assessment of fitness for a given treatment today serves an important role in tailoring therapeutic options. Areas covered: This review examines the main options used in real life to define eligibility for intensive and nonintensive chemotherapy in patients with AML, with a main focus on the Italian SIE/SIES/GITMO Consensus Criteria. Other published real-life experiences are also reviewed, analyzing the correlation between these criteria and short-term mortality, and thus expected outcomes. Expert opinion: Assessment of fitness is mandatory at diagnosis to tailor treatment to the greatest degree possible, evaluating the patient’s individual profile. This is especially relevant when considering the availability of newer, less toxic therapeutic regimens, which have shown promising results in patients with AML who are older or considered unfit for intensive treatment. Fitness assessment is now a fundamental part of AML management and a critical step that can potentially influence outcomes and not just predict them.

Published
2023

7. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi

Author

Chowdhary, A., Meis, J.F., Guarro, J., de Hoog, G.S., Kathuria, S., Arendrup, M.C., Arikan-Akdagli, S., Akova, M., Boekhout, T., Caira, M., Guinea, J., Chakrabarti, A., Dannaoui, E., van Diepeningen, A., Freiberger, T., Groll, A.H., Hope, W.W., Johnson, E., Lackner, M., Lagrou, K., Lanternier, F., Lass-Flörl, C., Lortholary, O., Meletiadis, J., Muñoz, P., Pagano, L., Petrikkos, G., Richardson, M.D., Roilides, E., Skiada, A., Tortorano, A.M., Ullmann, A.J., Verweij, P.E., Cornely, O.A., and Cuenca-Estrella, M.

Published
2014
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8. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others

Author

Tortorano, A.M., Richardson, M., Roilides, E., van Diepeningen, A., Caira, M., Munoz, P., Johnson, E., Meletiadis, J., Pana, Z.-D., Lackner, M., Verweij, P., Freiberger, T., Cornely, O.A., Arikan-Akdagli, S., Dannaoui, E., Groll, A.H., Lagrou, K., Chakrabarti, A., Lanternier, F., Pagano, L., Skiada, A., Akova, M., Arendrup, M.C., Boekhout, T., Chowdhary, A., Cuenca-Estrella, M., Guinea, J., Guarro, J., de Hoog, S., Hope, W., Kathuria, S., Lortholary, O., Meis, J.F., Ullmann, A.J., Petrikkos, G., and Lass-Flörl, C.

Published
2014
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14. European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe

Author

Tortorano, A. M., Prigitano, A., Esposto, M. C., Arsic Arsenijevic, V., Kolarovic, J., Ivanovic, D., Paripovic, L., Klingspor, L., Nordøy, I., Hamal, P., Arikan Akdagli, S., Ossi, C., Grancini, A., Cavanna, C., Lo Cascio, G., Scarparo, C., Candoni, A., Caira, M., Drogari Apiranthitou, M., and On the behalf of the ECMM Working Group

Published
2014
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15. SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients

Author

Montagna, M. T., Lovero, G., Coretti, C., Martinelli, D., Delia, M., De Giglio, O., Caira, M., Puntillo, F., D’Antonio, D., Venditti, M., Sambri, V., Di Bernardo, F., Barbui, A., Lo Cascio, G., Concia, E., Mikulska, M., Viscoli, C., Maximova, N., Candoni, A., Oliveri, S., Lombardi, G., Pitzurra, L., Sanguinetti, M., Masciari, R., Santantonio, T., Andreoni, S., Barchiesi, F., Pecile, P., Farina, C., Viale, P., Specchia, G., Caggiano, G., and Pagano, L.

Published
2014
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18. A prospective survey of febrile events in hematological malignancies

Author

Pagano, L., Caira, M., Rossi, G., Tumbarello, M., Fanci, R., Garzia, M. G., Vianelli, N., Filardi, N., De Fabritiis, P., Beltrame, A., Musso, M., Piccin, A., Cuneo, A., Cattaneo, C., Aloisi, T., Riva, M., Rossi, G., Salvadori, U., Brugiatelli, M., Sannicolò, S., Morselli, M., Bonini, A., Viale, P., Nosari, A., Aversa, F., and for the Hema e-Chart Group, Italy

Published
2012
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26. Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study - Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne

Author

Pagano, L., Caira, M., Nosari, A., Van Lint, M.T., Candoni, A., Offidani, M., Aloisi, T., Irrera, G., Bonini, A., Picardi, M., Caramatti, C., Invernizzi, R., Mattei, D., Melillo, L., de Waure, C., Reddiconto, G., Fianchi, L., Valentini, C.G., Girmenia, C., Leone, G., and Aversa, F.

Subjects
Mycoses -- Causes of, Mycoses -- Health aspects, Mycoses -- Care and treatment, Mycoses -- Research, Organ transplant recipients -- Health aspects, Organ transplant recipients -- Patient outcomes, Hematopoietic stem cells -- Transplantation, Hematopoietic stem cells -- Methods, Hematopoietic stem cells -- Complications and side effects, Health, Health care industry
Published
2007

35. Evaluation on ‘real life’ prescriptions of antifungal prophylaxis in acute myeloid leukemia: Final results from a prospective survey: C12-3

Author

Caira, M., Busca, A., Candoni, A., Melillo, L., Blasi, R. Di, Cuccaro, A., Caramatti, C., Specchia, G., Fanci, R., Rossi, G., Vacca, A., Quintavalle, C., Picardi, M., Mitra, M. E., Delia, M., Landini, B., Aversa, F., Gasbarrino, C., Invernizzi, R., Salutari, P., Martino, B., Garzia, M. G., Chierichini, A., Caprio, L. Di, Vianelli, N., Nadali, G., Luppi, M., Nosari, A., and Pagano, L.

Published
2012

48. Cyclodextrin complexes of the anticonvulsant agent valproic acid.

Author

Vicatos, A. I. and Caira, M. R.

Subjects
*VALPROIC acid, *X-ray powder diffraction, *ANTICONVULSANTS, *SINGLE crystals, *PHENOBARBITAL, *THERMAL analysis
Abstract

Six cyclodextrin (CD) complexes of the antiepileptic drug valproic acid (VAL) were prepared by kneading and/or co-precipitation methods and characterized by thermal analysis, powder X-ray diffraction and spectroscopic (1H NMR and FT-IR) techniques. The complexes (with host–guest stoichiometries in parentheses) included α-CD·VAL (2 : 1), β-CD·VAL (1 : 1), γ-CD·VAL (3 : 4), DMB·VAL (1 : 1), TMB·VAL (1 : 1) and TMA·VAL (1 : 1). Single crystal X-ray structures of four of the complexes were determined, those with β-CD and γ-CD featuring severely disordered guest molecules. Instead, the VAL molecules in the complexes with dimethylated β-CD (DMB) and permethylated α-CD (TMA) could be modelled, revealing modes of inclusion of valproic acid in CDs for the first time. The aqueous solubility values at 27 °C for VAL in the form of the solid complexes α-CD·VAL, β-CD·VAL and γ-CD·VAL were in the range 0.26–0.58 times that of the pure liquid phase of VAL. The merits of CD inclusion of VAL (e.g. transformation of the liquid guest into a solid, potential for reduction of adverse side effects) are discussed. [ABSTRACT FROM AUTHOR]

Published
2021
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