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The collagenous fibroma (desmoplastic fibroblastoma) is a rare benign soft tissue tumour that can occur in the oral mucosa; intraosseous lesion is uncommon. A 43-year-old woman showed a well-circumscribed intraosseous radiolucency involving the maxillary edentulous area corresponding to 22 and 23 teeth. On intraoral examination, the edentulous ridge was covered by normal oral mucosa. The patient underwent an excisional biopsy and histopathological analysis revealed a tumour composed of spindle to stellate shaped cells scattered within a myxocollagenous stroma with invasion of skeletal muscle. The collagen bands showed strong positivity for Masson’s trichrome and the tumour cells showed focal positivity for HHF-35 and α-smooth muscle actin. The diagnosis was intraosseous collagenous fibroma according to both clinical and histopathological patterns. The patient was followed up for six months and there were no signs of recurrences. We report the second case of oral intraosseous collagenous fibroma and a critical review of English literature of the tumour in oral cavity.

Made available in DSpace on 2018-11-26T17:55:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-08-05 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) University of Sao Paulo [USP] The initiation or progression of periodontitis might involve a local renin-angiotensin system (RAS) in periodontal tissue. The aim of this study was to further characterize the local RAS in human and rat periodontal tissues between healthy and periodontally-affected tissue. Components of the RAS were investigated using in vitro, ex vivo and in vivo experiments involving both human and Wistar rat periodontium. Although not upregulated when challenged with P. gingivalis-lipopolysaccharide, human gingival and periodontal ligament fibroblasts expressed RAS components. Likewise, healthy and inflamed human gingiva expressed RAS components, some of which were shown to be functional, yet no differences in expression were found between healthy and diseased gingiva. However, in inflamed tissue the immunoreactivity was greater for the AT(1)R compared to AT(2)R in fibroblasts. When compared to healthy tissue, ACE activity was increased in human gingiva from volunteers with gingivitis. Human-gingiva homogenates generated Ang II, Ang 1-9 and Ang 1-7 when incubated with precursors. In gingiva homogenates, Ang II formation from Ang I was nearly abolished only when captopril and chymostatin were combined. Ang 1-7 formation was significantly greater when human gingiva homogenates were incubated with chymostatin alone compared to incubation without any inhibitor, only captopril, or captopril and chymostatin. In rat gingiva, RAS components were also found; their expression was not different between healthy and experimentally induced periodontitis (EP) groups. However, renin inhibition (aliskiren) and an AT(1)R antagonist (losartan) significantly blocked EP-alveolar-bone loss in rats. Collectively, these data are consistent with the hypothesis that a local RAS system is not only present but is also functional in both human and rat periodontal tissue. Furthermore, blocking AT(1)R and renin can significantly prevent periodontal bone loss induced by EP in rats. Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Sao Paulo, Brazil Univ Sao Paulo, Sch Dent, Dept Restorat Dent, Sao Paulo, Brazil Sao Paulo State Univ, Fac Sci, Dept Phys Educ, Sao Paulo, Brazil Univ Sao Paulo, Sch Med Ribeirao Preto, Sao Paulo, Brazil Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Sao Paulo State Univ, Fac Sci, Dept Phys Educ, Sao Paulo, Brazil FAPESP: 2004/13479-3 FAPESP: 2005/60167-0 FAPESP: 2009/53848-1 FAPESP: 2009/15372-5 FAPESP: 2010/01230-1 FAPESP: 2013/16113-9 CNPq: 473856/2010-7 CNPq: 558171/2010-9 CNPq: 303494/2013-1 CNPq: 506802/2013-2 CNPq: 480160/2013-9 CAPES: 2435/09-9 University of Sao Paulo [USP]: 08.1.2066.25.3

This study is intended to verify the correlation among clinical indices of the peri-implant soft tissues, the histological condition and the presence of 3 pathogens commonly associated with peri-implant diseases (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia).Four clinical indices, Gingival Index (GI), Sulcus Bleeding Index, GI modified by Mombelli, and Plaque Index modified by Mombelli (mPI) were evaluated around 1 dental implant of each subject (n = 10). Subgingival plaque was collected for bacterial analysis (polymerase chain reaction) and a biopsy of peri-implant soft tissues for histological analysis was harvested. The clinical indices and detected pathogens correlated with a developed histological index (HI).There was no statistically significant relationship between the clinical indices (GI, Sulcus Bleeding Index, and GI modified by Mombelli) and the HI, except for the mPI on the central area of lingual aspects (r = 0.85, P = 0.0029). There was a tendency for a positive correlation between the mPI on the central area of buccal aspects and the HI (r = 0.63, P = 0.0544). The counting of lymphocytes and plasmocytes correlated positively with HI, thus suggesting the index reliability. The prevalence of A. actinomycetemcomitans, P. gingivalis, and T. forsythia did not present a significant relationship with the HI.Despite the small number of samples and the poor statistical significance, the mPI seems to be useful for evaluation of inflammatory severity on soft tissue around dental implants as demonstrated by its relationship with the HI. Further studies are necessary to elucidate this subject.

This case report describes a technique that uses a palatal mucosal graft and an acrylic resin postoperative stent in an attempt to increase the layer of keratinized tissue around osseointegrated implants in an atrophic mandible. During second-stage surgery, a split-thickness labial flap is reflected and apically repositioned by being sutured onto the periosteum and connective tissue. A palatal mucosal graft is then sutured onto the recipient site. The stent is worn for at least 4 weeks following surgery. This procedure helps to eliminate mobility of the mucosa in the area, deepen the vestibule, and prevent muscle reinsertion.