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1. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, TC, Khanna, A, Chicom-Mefire, A, Rodríguez-Baño, J, Nathwani, D, Mendelson, M, Watkins, RR, Pulcini, C, Beović, B, May, AK, Itani, KMF, Mazuski, JE, Fry, DE, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, LM, Abubakar, S, Abu-Zidan, FM, Adesunkanmi, AK, Al-Hasan, MN, Althani, AA, Ticas, JEA, Ansari, S, Ansumana, R, Da Silva, ARA, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bassetti, M, Bellanova, G, Beltran, MA, Ben-Ishay, O, Biffl, WL, Boermeester, MA, Brecher, SM, Bueno, J, Cainzos, MA, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, SJ, Cherry-Bukowiec, JR, Cirocchi, R, Colak, E, Corcione, A, Cornely, OA, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, HP, De Waele, J, Dhingra, S, Diaz, JJ, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, TM, Dupont, H, Egiev, VN, Eid, HO, Elmangory, M, El-Sayed Marei, H, Enani, MA, Escandón-Vargas, K, Faro, MP, Ferrada, P, Foghetti, D, Foianini, E, Fraga, GP, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, DA, Gomes, CA, Gomi, H, Gronerth, RIG, Guirao, X, Guzman-Blanco, M, Haque, M, and Hecker, A

Subjects
Antimicrobial Stewardship, Antifungal Agents, Anti-Infective Agents, Surgical Procedures, Operative, Humans, Surgical Wound Infection, Surgery, Drug Resistance, Microbial, Antibiotic Prophylaxis, Global Health, Anti-Bacterial Agents
Abstract

© Copyright 2017, Mary Ann Liebert, Inc. This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.

Published
2017

2. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author

Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R

Subjects
Surgery
Abstract

© The Author(s). The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'.

Published
2017

4. Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R

Subjects
Anti-Infective Agents, International Cooperation, Humans, Intraabdominal Infections, Surgery, Drug Resistance, Microbial, Microbial Sensitivity Tests, Prognosis
Abstract

© 2016 The Author(s). Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

5. Building a Novel Artificial Intelligence-Driven Echocardiographic Data Pipeline: Findings From a Large Learning Health System.

Author

Bose B, Butt SA, Arshad HB, Nicolas CC, Gullapelli R, Nwana N, Javed Z, Shahid I, Pournazari P, Patel K, Chamsi Pasha MA, Little SH, Faza NS, Jones S, Cainzos MA, Al-Kindi S, Saad JM, Zoghbi W, Nagueh SF, and Nasir K

Subjects
Humans, Learning Health System, Artificial Intelligence, Echocardiography methods
Abstract

Competing Interests: Conflicts of interest None.

Published
2024
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6. The Surgical Infection Society Guidelines on the Management of Intra-Abdominal Infection: 2024 Update.

Author

Huston JM, Barie PS, Dellinger EP, Forrester JD, Duane TM, Tessier JM, Sawyer RG, Cainzos MA, Rasa K, Chipman JG, Kao LS, Pieracci FM, Colling KP, Heffernan DS, and Lester J

Subjects
Humans, Surgical Wound Infection prevention & control, Surgical Wound Infection therapy, Surgical Wound Infection drug therapy, Anti-Bacterial Agents therapeutic use, Practice Guidelines as Topic, Intraabdominal Infections drug therapy, Intraabdominal Infections therapy
Abstract

Background: The Surgical Infection Society (SIS) published evidence-based guidelines for the management of intra-abdominal infection (IAI) in 1992, 2002, 2010, and 2017. Here, we present the most recent guideline update based on a systematic review of current literature. Methods: The writing group, including current and former members of the SIS Therapeutics and Guidelines Committee and other individuals with content or guideline expertise within the SIS, working with a professional librarian, performed a systematic review using PubMed/Medline, the Cochrane Library, Embase, and Web of Science from 2016 until February 2024. Keyword descriptors combined "surgical site infections" or "intra-abdominal infections" in adults limited to randomized controlled trials, systematic reviews, and meta-analyses. Additional relevant publications not in the initial search but identified during literature review were included. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system was utilized to evaluate the evidence. The strength of each recommendation was rated strong (1) or weak (2). The quality of the evidence was rated high (A), moderate (B), or weak (C). The guideline contains new recommendations and updates to recommendations from previous IAI guideline versions. Final recommendations were developed by an iterative process. All writing group members voted to accept or reject each recommendation. Results: This updated evidence-based guideline contains recommendations from the SIS for the treatment of adult patients with IAI. Evidence-based recommendations were developed for antimicrobial agent selection, timing, route of administration, duration, and de-escalation; timing of source control; treatment of specific pathogens; treatment of specific intra-abdominal disease processes; and implementation of hospital-based antimicrobial agent stewardship programs. Summary: This document contains the most up-to-date recommendations from the SIS on the prevention and management of IAI in adult patients.

Published
2024
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7. Knowledge, awareness, and attitude towards infection prevention and management among surgeons: identifying the surgeon champion.

Author

Sartelli M, Kluger Y, Ansaloni L, Coccolini F, Baiocchi GL, Hardcastle TC, Moore EE, May AK, Itani KMF, Fry DE, Boermeester MA, Guirao X, Napolitano L, Sawyer RG, Rasa K, Abu-Zidan FM, Adesunkanmi AK, Atanasov B, Augustin G, Bala M, Cainzos MA, Chichom-Mefire A, Cortese F, Damaskos D, Delibegovic S, Demetrashvili Z, De Simone B, Duane TM, Ghnnam W, Gkiokas G, Gomes CA, Hecker A, Karamarkovic A, Kenig J, Khokha V, Kong V, Isik A, Leppäniemi A, Litvin A, Lostoridis E, Machain GM, Marwah S, McFarlane M, Mesina C, Negoi I, Olaoye I, Pintar T, Pupelis G, Rems M, Rubio-Perez I, Sakakushev B, Segovia-Lohse H, Siribumrungwong B, Talving P, Ulrych J, Vereczkei AG, Labricciosa FM, and Catena F

Subjects
Adult, Female, Humans, Infection Control standards, Male, Middle Aged, Surgeons standards, Surgical Wound Infection prevention & control, United States, Health Knowledge, Attitudes, Practice, Infection Control methods, Surgeons psychology
Abstract

Despite evidence supporting the effectiveness of best practices of infection prevention and management, many surgeons worldwide fail to implement them. Evidence-based practices tend to be underused in routine practice. Surgeons with knowledge in surgical infections should provide feedback to prescribers and integrate best practices among surgeons and implement changes within their team. Identifying a local opinion leader to serve as a champion within the surgical department may be important. The "surgeon champion" can integrate best clinical practices of infection prevention and management, drive behavior change in their colleagues, and interact with both infection control teams in promoting antimicrobial stewardship., Competing Interests: Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Published
2018
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8. Erratum to: Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Author

Sartelli M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, Moore EE, Moore FA, Maier RV, De Waele JJ, Kirkpatrick AW, Griffiths EA, Eckmann C, Brink AJ, Mazuski JE, May AK, Sawyer RG, Mertz D, Montravers P, Kumar A, Roberts JA, Vincent JL, Watkins RR, Lowman W, Spellberg B, Abbott IJ, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Agresta F, Althani AA, Ansari S, Ansumana R, Augustin G, Bala M, Balogh ZJ, Baraket O, Bhangu A, Beltrán MA, Bernhard M, Biffl WL, Boermeester MA, Brecher SM, Cherry-Bukowiec JR, Buyne OR, Cainzos MA, Cairns KA, Camacho-Ortiz A, Chandy SJ, Che Jusoh A, Chichom-Mefire A, Colijn C, Corcione F, Cui Y, Curcio D, Delibegovic S, Demetrashvili Z, De Simone B, Dhingra S, Diaz JJ, Di Carlo I, Dillip A, Di Saverio S, Doyle MP, Dorj G, Dogjani A, Dupont H, Eachempati SR, Enani MA, Egiev VN, Elmangory MM, Ferrada P, Fitchett JR, Fraga GP, Guessennd N, Giamarellou H, Ghnnam W, Gkiokas G, Goldberg SR, Gomes CA, Gomi H, Guzmán-Blanco M, Haque M, Hansen S, Hecker A, Heizmann WR, Herzog T, Hodonou AM, Hong SK, Kafka-Ritsch R, Kaplan LJ, Kapoor G, Karamarkovic A, Kees MG, Kenig J, Kiguba R, Kim PK, Kluger Y, Khokha V, Koike K, Kok KY, Kong V, Knox MC, Inaba K, Isik A, Iskandar K, Ivatury RR, Labbate M, Labricciosa FM, Laterre PF, Latifi R, Lee JG, Lee YR, Leone M, Leppaniemi A, Li Y, Liang SY, Loho T, Maegele M, Malama S, Marei HE, Martin-Loeches I, Marwah S, Massele A, McFarlane M, Melo RB, Negoi I, Nicolau DP, Nord CE, Ofori-Asenso R, Omari AH, Ordonez CA, Ouadii M, Pereira Júnior GA, Piazza D, Pupelis G, Rawson TM, Rems M, Rizoli S, Rocha C, Sakakushev B, Sanchez-Garcia M, Sato N, Segovia Lohse HA, Sganga G, Siribumrungwong B, Shelat VG, Soreide K, Soto R, Talving P, Tilsed JV, Timsit JF, Trueba G, Trung NT, Ulrych J, van Goor H, Vereczkei A, Vohra RS, Wani I, Uhl W, Xiao Y, Yuan KC, Zachariah SK, Zahar JR, Zakrison TL, Corcione A, Melotti RM, Viscoli C, and Viale P

Abstract

[This corrects the article DOI: 10.1186/s13017-016-0089-y.].

Published
2017
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9. Erratum to: The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections.

Author

Sartelli M, Chichom-Mefire A, Labricciosa FM, Hardcastle T, Abu-Zidan FM, Adesunkanmi AK, Ansaloni L, Bala M, Balogh ZJ, Beltrán MA, Ben-Ishay O, Biffl WL, Birindelli A, Cainzos MA, Catalini G, Ceresoli M, Che Jusoh A, Chiara O, Coccolini F, Coimbra R, Cortese F, Demetrashvili Z, Di Saverio S, Diaz JJ, Egiev VN, Ferrada P, Fraga GP, Ghnnam WM, Lee JG, Gomes CA, Hecker A, Herzog T, Kim JI, Inaba K, Isik A, Karamarkovic A, Kashuk J, Khokha V, Kirkpatrick AW, Kluger Y, Koike K, Kong VY, Leppaniemi A, Machain GM, Maier RV, Marwah S, McFarlane ME, Montori G, Moore EE, Negoi I, Olaoye I, Omari AH, Ordonez CA, Pereira BM, Pereira Júnior GA, Pupelis G, Reis T, Sakakushev B, Sato N, Segovia Lohse HA, Shelat VG, Søreide K, Uhl W, Ulrych J, Van Goor H, Velmahos GC, Yuan KC, Wani I, Weber DG, Zachariah SK, and Catena F

Abstract

[This corrects the article DOI: 10.1186/s13017-017-0141-6.].

Published
2017
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10. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections.

Author

Sartelli M, Chichom-Mefire A, Labricciosa FM, Hardcastle T, Abu-Zidan FM, Adesunkanmi AK, Ansaloni L, Bala M, Balogh ZJ, Beltrán MA, Ben-Ishay O, Biffl WL, Birindelli A, Cainzos MA, Catalini G, Ceresoli M, Che Jusoh A, Chiara O, Coccolini F, Coimbra R, Cortese F, Demetrashvili Z, Di Saverio S, Diaz JJ, Egiev VN, Ferrada P, Fraga GP, Ghnnam WM, Lee JG, Gomes CA, Hecker A, Herzog T, Kim JI, Inaba K, Isik A, Karamarkovic A, Kashuk J, Khokha V, Kirkpatrick AW, Kluger Y, Koike K, Kong VY, Leppaniemi A, Machain GM, Maier RV, Marwah S, McFarlane ME, Montori G, Moore EE, Negoi I, Olaoye I, Omari AH, Ordonez CA, Pereira BM, Pereira Júnior GA, Pupelis G, Reis T, Sakakhushev B, Sato N, Segovia Lohse HA, Shelat VG, Søreide K, Uhl W, Ulrych J, Van Goor H, Velmahos GC, Yuan KC, Wani I, Weber DG, Zachariah SK, and Catena F

Subjects
Abdominal Injuries drug therapy, Abdominal Injuries surgery, Anti-Bacterial Agents therapeutic use, Disease Management, Humans, Organ Dysfunction Scores, Peritonitis drug therapy, Sepsis drug therapy, Sepsis surgery, Societies, Medical organization & administration, Surgeons organization & administration, Surgeons trends, Guidelines as Topic, Intraabdominal Infections drug therapy, Intraabdominal Infections surgery, Societies, Medical trends
Abstract

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departments worldwide. The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy. Prompt resuscitation of patients with ongoing sepsis is of utmost important. In hospitals worldwide, non-acceptance of, or lack of access to, accessible evidence-based practices and guidelines result in overall poorer outcome of patients suffering IAIs. The aim of this paper is to promote global standards of care in IAIs and update the 2013 WSES guidelines for management of intra-abdominal infections.

Published
2017
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11. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Author

Sartelli M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, Moore EE, Moore FA, Maier RV, De Waele JJ, Kirkpatrick AW, Griffiths EA, Eckmann C, Brink AJ, Mazuski JE, May AK, Sawyer RG, Mertz D, Montravers P, Kumar A, Roberts JA, Vincent JL, Watkins RR, Lowman W, Spellberg B, Abbott IJ, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Agresta F, Althani AA, Ansari S, Ansumana R, Augustin G, Bala M, Balogh ZJ, Baraket O, Bhangu A, Beltrán MA, Bernhard M, Biffl WL, Boermeester MA, Brecher SM, Cherry-Bukowiec JR, Buyne OR, Cainzos MA, Cairns KA, Camacho-Ortiz A, Chandy SJ, Che Jusoh A, Chichom-Mefire A, Colijn C, Corcione F, Cui Y, Curcio D, Delibegovic S, Demetrashvili Z, De Simone B, Dhingra S, Diaz JJ, Di Carlo I, Dillip A, Di Saverio S, Doyle MP, Dorj G, Dogjani A, Dupont H, Eachempati SR, Enani MA, Egiev VN, Elmangory MM, Ferrada P, Fitchett JR, Fraga GP, Guessennd N, Giamarellou H, Ghnnam W, Gkiokas G, Goldberg SR, Gomes CA, Gomi H, Guzmán-Blanco M, Haque M, Hansen S, Hecker A, Heizmann WR, Herzog T, Hodonou AM, Hong SK, Kafka-Ritsch R, Kaplan LJ, Kapoor G, Karamarkovic A, Kees MG, Kenig J, Kiguba R, Kim PK, Kluger Y, Khokha V, Koike K, Kok KY, Kong V, Knox MC, Inaba K, Isik A, Iskandar K, Ivatury RR, Labbate M, Labricciosa FM, Laterre PF, Latifi R, Lee JG, Lee YR, Leone M, Leppaniemi A, Li Y, Liang SY, Loho T, Maegele M, Malama S, Marei HE, Martin-Loeches I, Marwah S, Massele A, McFarlane M, Melo RB, Negoi I, Nicolau DP, Nord CE, Ofori-Asenso R, Omari AH, Ordonez CA, Ouadii M, Pereira Júnior GA, Piazza D, Pupelis G, Rawson TM, Rems M, Rizoli S, Rocha C, Sakakushev B, Sanchez-Garcia M, Sato N, Segovia Lohse HA, Sganga G, Siribumrungwong B, Shelat VG, Soreide K, Soto R, Talving P, Tilsed JV, Timsit JF, Trueba G, Trung NT, Ulrych J, van Goor H, Vereczkei A, Vohra RS, Wani I, Uhl W, Xiao Y, Yuan KC, Zachariah SK, Zahar JR, Zakrison TL, Corcione A, Melotti RM, Viscoli C, and Viale P

Subjects
Drug Resistance, Microbial, Humans, Microbial Sensitivity Tests, Prognosis, Anti-Infective Agents pharmacology, International Cooperation, Intraabdominal Infections diagnosis, Intraabdominal Infections drug therapy, Intraabdominal Infections microbiology
Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016
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12. Informed consent in surgery.

Author

Cainzos MA and González-Vinagre S

Subjects
Health Literacy, Humans, Mental Competency, Informed Consent ethics, Patient Education as Topic ethics, Patient Participation, Physician-Patient Relations ethics, Specialties, Surgical ethics
Published
2014
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13. Antibiotic prophylaxis.

Author

Cainzos MA

Subjects
Antibiotic Prophylaxis adverse effects, Antibiotic Prophylaxis trends, Humans, Hypersensitivity, Delayed immunology, Immunotherapy, Patient Selection, Sepsis prevention & control, Antibiotic Prophylaxis methods, Surgical Wound Infection prevention & control
Abstract

During the past 30 years, antibiotic prophylaxis has proved of enormous efficacy in reducing the incidence of surgical wound infections, postoperative morbidity and mortality, the duration of the postoperative period, and the overall cost of surgical treatment. In this paper, the timing and route of administration of antibiotic prophylaxis as well as the dosage and duration, the indications for antibiotic prophylaxis, the importance of the alterations of the delayed hypersensitivity response, and the value of antibiotic prophylaxis for prevention of postoperative septic complications in anergic patients are analyzed. The possibility of combining antibiotic prophylaxis with immunoprophylaxis for high-risk patients is also analyzed.

Published
1998

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