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7. Efficacy and safety of rituximab with and without methotrexate in the treatment of rheumatoid arthritis patients: Results from the GISEA register

Author

Sebastiani, Marco, Anelli, Maria Grazia, Atzeni, Fabiola, Bazzani, Chiara, Farina, Ilaria, Fedele, Anna Laura, Favalli, Ennio Giulio, Fineschi, Irene, Cino, Nicolò, Dal Forno, Ilaria, Gasparini, Stefania, Cassarà, Emanuele, Giardina, Rita, Bruschi, Eleonora, Addimanda, Olga, Cassone, Giulia, Lopriore, Simona, Sarzi-Puttini, Piercarlo, Filippini, Matteo, Pignatti, Federica, Gremese, Elisa, Biggioggero, Martina, Manganelli, Stefania, Amato, Giorgio, Caimmi, Cristian, Salaffi, Fausto, Iannone, Florenzo, Ferri, Clodoveo, Sandri, Gilda, Lapadula, Giovanni, Gorla, Roberto, Govoni, Marcello, Ferraccioli, Gianfranco, Marchesoni, Antonio, Galeazzi, Mauro, Foti, Rosario, Carletto, Antonio, Cantini, Fabrizio, Triolo, Giovanni, Epis, Oscar Massimiliano, and Salvarani, Carlo

Published
2014
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18. Smoking in Systemic Sclerosis: a Longitudinal European Scleroderma Trials and Research Group Study

Author

Jaeger, Veronika K, Valentini, Gabriele, Hachulla, Eric, Cozzi, Franco, Distler, Oliver, Airó, Paolo, Czirják, Laszlo, Allanore, Yannick, Siegert, Elise, Rosato, Edoardo, Matucci-Cerinic, Marco, Caimmi, Cristian, Henes, Jörg, Carreira, Patricia E, Smith, Vanessa, Del Galdo, Francesco, Denton, Christopher P, Ullman, Susanne, Langhe, Ellen De, Riccieri, Valeria, Alegre-Sancho, Juan J, Rednic, Simona, Müller-Ladner, Ulf, Walker, Ulrich A, Jaeger, Veronika K, Valentini, Gabriele, Hachulla, Eric, Cozzi, Franco, Distler, Oliver, Airó, Paolo, Czirják, Laszlo, Allanore, Yannick, Siegert, Elise, Rosato, Edoardo, Matucci-Cerinic, Marco, Caimmi, Cristian, Henes, Jörg, Carreira, Patricia E, Smith, Vanessa, Del Galdo, Francesco, Denton, Christopher P, Ullman, Susanne, Langhe, Ellen De, Riccieri, Valeria, Alegre-Sancho, Juan J, Rednic, Simona, Müller-Ladner, Ulf, and Walker, Ulrich A

Subjects
Systemic sclerosi, prevalence, organ manifestation, progression, smoking, respiratory tract diseases
Abstract

OBJECTIVE: Data on the role of tobacco exposure in systemic sclerosis (SSc; scleroderma) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations, based on the European Scleroderma Trials and Research group database. METHODS: Adult SSc patients with data on smoking history and a 12-24-month follow-up visit were included. Associations of severity and progression of organ involvement with smoking history and the Comprehensive Smoking Index were assessed using multivariable regression analyses. RESULTS: A total of 3,319 patients were included (mean age 57 years, 85% female); 66% were never smokers, 23% were ex-smokers, and 11% were current smokers. Current smokers had a lower percentage of antitopoisomerase autoantibodies than previous or never smokers (31% versus 40% and 45%, respectively). Never smokers had a higher baseline forced expiratory volume in 1 second/forced vital capacity (FEV1 /FVC) ratio than previous and current smokers (P < 0.001). The FEV1 /FVC ratio declined faster in current smokers than in never smokers (P = 0.05) or ex-smokers (P = 0.01). The baseline modified Rodnan skin thickness score (MRSS) and the MRSS decline were comparable across smoking groups. Although heavy smoking (>25 pack-years) increased the odds of digital ulcers by almost 50%, there was no robust adverse association of smoking with digital ulcer development. CONCLUSION: The known adverse effect of smoking on bronchial airways and alveoli is also observed in SSc patients; however, robust adverse effects of smoking on the progression of SSc-specific pulmonary or cutaneous manifestations were not observed. ispartof: Arthritis and Rheumatology vol:70 issue:11 pages:1829-1834 ispartof: location:United States status: published

Published
2018

19. Ultrasonography involvement of carotid, upper and lower limb arteries in a large cohort of systemic sclerosis patients

Author

Caimmi, Cristian, De Marchi, Sergio, Bosello, Silvia Laura, Giuggioli, Dilia, Caramaschi, Paola, Di Giorgio, Angela, Spinella, Amelia, Astorino, Giulia, Canestrari, Giovanni, Cocchiara, Emanuele, Gremese, Elisa, Viapiana, Ombretta, Rossini, Maurizio, Bosello, Silvia Laura (ORCID:0000-0002-4837-447X), Gremese, Elisa (ORCID:0000-0002-2248-1058), Caimmi, Cristian, De Marchi, Sergio, Bosello, Silvia Laura, Giuggioli, Dilia, Caramaschi, Paola, Di Giorgio, Angela, Spinella, Amelia, Astorino, Giulia, Canestrari, Giovanni, Cocchiara, Emanuele, Gremese, Elisa, Viapiana, Ombretta, Rossini, Maurizio, Bosello, Silvia Laura (ORCID:0000-0002-4837-447X), and Gremese, Elisa (ORCID:0000-0002-2248-1058)

Abstract

Objectives Data on macrovascular involvement in systemic sclerosis (SSc) are still debatable. The aim of this study was to estimate its prevalence and possible determinants in a large cohort.Methods One hundred and fifty-five outpatients with SSc were enrolled. Data about disease characteristics and cardiovascular risk factors were collected and patients underwent ecocolor Doppler ultrasonography of arteries of the neck and lower (LL) and upper (UL) limbs.Results Mean age was 57.9 +/- 14.5 years and most were female (88.4%) with a limited subset (63.2%). Mean disease duration was 11.4 +/- 8.1 years. Twenty-three (14.8%) had hypertension, 7 (4.8%) diabetes, 64 (41.3%) hypercholesterolemia and 63 (40.6%) were active/past smokers. Seventy-nine (49%) patients had plaques at carotids, 49 (32.9%) at LL and 7 (4.9%) at UL. In multivariate analysis, patients with carotid plaques had more often a limited pattern (P = .001), patients with distal LL plaques pulmonary arterial hypertension (P = .006) and patients with proximal LL plaques lower diffusing capacity for carbon monoxide adjusted to hemoglobin and its ratio to alveolar volume (P = .004). In patients with UL plaques traditional cardiovascular risk factors were not more common, while forced vital capacity was lower (P = .023). Finally, upper limb and proximal LL plaques were as common in early disease patients as in longstanding ones, although the former were younger.Conclusions This study shows that macrovascular involvement is quite common in SSc and that some disease characteristics linked to microvascular involvement are associated with atherosclerotic plaques, which can be present even in early disease. Our study suggests that a complete evaluation of macrocirculation is mandatory for rheumatologists treating SSc patients.

Published
2020

23. Ultrasonography involvement of carotid, upper and lower limb arteries in a large cohort of systemic sclerosis patients

Author

Caimmi, Cristian, primary, De Marchi, Sergio, additional, Bosello, Silvia Laura, additional, Giuggioli, Dilia, additional, Caramaschi, Paola, additional, Di Giorgio, Angela, additional, Spinella, Amelia, additional, Astorino, Giulia, additional, Canestrari, Giovanni, additional, Cocchiara, Emanuele, additional, Gremese, Elisa, additional, Viapiana, Ombretta, additional, and Rossini, Maurizio, additional

Published
2020
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24. Ultrasonographic detection, definition and quantification of soft tissue oedema in psoriatic dactylitis

Author

Tinazzi, Ilaria, primary, Idolazzi, Luca, additional, Zabotti, Alen, additional, Arancio, Luisa, additional, Batticiotto, Alberto, additional, Caimmi, Cristian, additional, De Lucia, Orazio, additional, Fassio, Angelo, additional, Girolimetto, Nicolò, additional, Macchioni, Pierluigi, additional, Murgo, Antonella, additional, Sakellariou, Garifallia, additional, and Iagnocco, Annamaria, additional

Published
2019
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25. Imaging in Systemic Sclerosis make 'US' great again?

Author

Lescoat, Alain, Caimmi, Cristian, Hachulla, Éric, Jego, Patrick, Coiffier, Guillaume, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU Pontchaillou [Rennes], Università degli studi di Verona = University of Verona (UNIVR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Jonchère, Laurent, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Verona (UNIVR), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Skin Dear Editor, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Ultrasound, Systemic sclerosis, Power Doppler Ultrasonography, Scleroderma
Abstract

International audience; In this issue of Arthritis Care and Research, T. Santiago and colleagues [1] have conducted an informative systematic literature review on the relevance of ultrasound (US) for the assessment of skin involvement in systemic sclerosis (SSc). In this Original Article, the authors highlight the heterogeneous results concerning the reliability of US in studies published to date, but also underscore very promising data from recently published articles [2]. Moreover, this work raises the issue considering US evaluation as an interesting alternative to mRSS for skin assessment in SSc. Therefore, beyond imaging considerations, this article questions the place of US evaluation in the global management of SSc. This topic is still a controversial matter as new assessment technics are emerging for microvascular, macrovascular and musculoskeletal evaluations in SSc.

Published
2019

26. Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study

Author

Elhai, Muriel, Boubaya, Marouane, Distler, Oliver, Smith, Vanessa, Matucci-Cerinic, Marco, Alegre Sancho, Juan Jose, Truchetet, Marie-Elise, Braun-Moscovici, Yolanda, Iannone, Florenzo, Novikov, Pavel I., Lescoat, Alain, Siegert, Elise, Castellvi, Ivan, Airo, Paolo, Vettori, Serena, De Langhe, Ellen, Hachulla, Eric, Erler, Anne, Ananieva, Lidia, Krusche, Martin, Lopez-Longo, F. J., Distler, Joerg H. W., Hunzelmann, Nicolas, Hoffmann-Vold, Anna-Maria, Riccieri, Valeria, Hsu, Vivien M., Pozzi, Maria R., Ancuta, Codrina, Rosato, Edoardo, Mihai, Carina, Kuwana, Masataka, Saketkoo, Lesley Ann, Chizzolini, Carlo, Hesselstrand, Roger, Ullman, Susanne, Yavuz, Sule, Rednic, Simona, Caimmi, Cristian, Bloch-Queyrat, Coralie, Allanore, Yannick, Guiducci, Serena, Walker, Ulrich A., Kyburz, Diego, Lapadula, Giovanni, Maurer, Britta, Jordan, Suzana, Dobrota, Rucsandra, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Sulli, Alberto, Cutolo, Maurizio, Cuomo, Giovanna, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis G., Montecucco, Carlo Maurizio, Caporali, Roberto, Stork, Jiri, Inanc, Murat, Carreira, Patricia E., Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Wollheim, Frank, Scheja, Agneta, Wuttge, Dirk M., Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Trotta, F., Lo Monaco, Andrea, Pellerito, Raffaele, Mauriziano, Ospedale, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Jorg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Da Silva, Jose Antonio Pereira, Salvador, Maria Joao, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Tikly, Mohammed, Denisov, Lev N., Herrick, Ariane, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriela, Mendoza, Antonio Zea, de la Puente, Carlos, Giraldo, Sifuentes W. A., Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Launay, David, Valesini, Guido, Ionescu, Ruxandra Maria, Groseanu, Laura, Opris, Daniela, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Milicescu, Mihaela, Sunderkotter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Melsens, Karin, Cantatore, Francesco P., Corrado, Ada, Iversen, Line, von Muhlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Eyerich, Kilian, Hein, Rudiger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A., Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Gunther, Claudia, Westhovens, Rene, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Granel, Brigitte, Muller, Carolina de Souza, Radominski, Sebastiao C., Azevedo, Valderilio F., Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Yoshinari, Natalino H., Marangoni, Roberta G., Martin, Patricia, Fuocco, Luiza, Stebbings, Simon, Highton, John, Chapman, Peter, O'Donnell, John, Stamp, Lisa, Doube, Alan, Solanki, Kamal, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Furst, Daniel, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Fathi, Nihal, Hassanien, Manal, Lefebvre, Paloma Garcia de la Pena, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Chatelus, Emmanuel, Sibilia, Jean, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Lasky, Joseph A., Cosentino, Vanesa, Kerzberg, Eduardo, Montoya, Fabiana, Bianchi, Washington, Carneiro, Sueli, Maretti, Giselle Baptista, Bianchi, Dante Valdetaro, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Kahl, Sarah, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chotchaeva, Fatima, Mukhin, Nikolay A., Moiseev, Sergey, Elhai, Muriel, Boubaya, Marouane, Distler, Oliver, Smith, Vanessa, Matucci-Cerinic, Marco, Alegre Sancho, Juan Jose, Truchetet, Marie-Elise, Braun-Moscovici, Yolanda, Iannone, Florenzo, Novikov, Pavel I., Lescoat, Alain, Siegert, Elise, Castellvi, Ivan, Airo, Paolo, Vettori, Serena, De Langhe, Ellen, Hachulla, Eric, Erler, Anne, Ananieva, Lidia, Krusche, Martin, Lopez-Longo, F. J., Distler, Joerg H. W., Hunzelmann, Nicolas, Hoffmann-Vold, Anna-Maria, Riccieri, Valeria, Hsu, Vivien M., Pozzi, Maria R., Ancuta, Codrina, Rosato, Edoardo, Mihai, Carina, Kuwana, Masataka, Saketkoo, Lesley Ann, Chizzolini, Carlo, Hesselstrand, Roger, Ullman, Susanne, Yavuz, Sule, Rednic, Simona, Caimmi, Cristian, Bloch-Queyrat, Coralie, Allanore, Yannick, Guiducci, Serena, Walker, Ulrich A., Kyburz, Diego, Lapadula, Giovanni, Maurer, Britta, Jordan, Suzana, Dobrota, Rucsandra, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Sulli, Alberto, Cutolo, Maurizio, Cuomo, Giovanna, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis G., Montecucco, Carlo Maurizio, Caporali, Roberto, Stork, Jiri, Inanc, Murat, Carreira, Patricia E., Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Wollheim, Frank, Scheja, Agneta, Wuttge, Dirk M., Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Trotta, F., Lo Monaco, Andrea, Pellerito, Raffaele, Mauriziano, Ospedale, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Jorg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Da Silva, Jose Antonio Pereira, Salvador, Maria Joao, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Tikly, Mohammed, Denisov, Lev N., Herrick, Ariane, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriela, Mendoza, Antonio Zea, de la Puente, Carlos, Giraldo, Sifuentes W. A., Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Launay, David, Valesini, Guido, Ionescu, Ruxandra Maria, Groseanu, Laura, Opris, Daniela, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Milicescu, Mihaela, Sunderkotter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Melsens, Karin, Cantatore, Francesco P., Corrado, Ada, Iversen, Line, von Muhlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Eyerich, Kilian, Hein, Rudiger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A., Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Gunther, Claudia, Westhovens, Rene, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Granel, Brigitte, Muller, Carolina de Souza, Radominski, Sebastiao C., Azevedo, Valderilio F., Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Yoshinari, Natalino H., Marangoni, Roberta G., Martin, Patricia, Fuocco, Luiza, Stebbings, Simon, Highton, John, Chapman, Peter, O'Donnell, John, Stamp, Lisa, Doube, Alan, Solanki, Kamal, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Furst, Daniel, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Fathi, Nihal, Hassanien, Manal, Lefebvre, Paloma Garcia de la Pena, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Chatelus, Emmanuel, Sibilia, Jean, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Lasky, Joseph A., Cosentino, Vanesa, Kerzberg, Eduardo, Montoya, Fabiana, Bianchi, Washington, Carneiro, Sueli, Maretti, Giselle Baptista, Bianchi, Dante Valdetaro, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Kahl, Sarah, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chotchaeva, Fatima, Mukhin, Nikolay A., and Moiseev, Sergey

Abstract

Objective To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice. Methods We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab. Results 254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47-5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55-1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56-3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83-9.62]; p=0.019 as compared with controls vs 3 [0.66-5.35]; p=0.012). Conclusion Rituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.

Published
2019

27. Dramatic improvement of anti-SS-A/Ro-associated interstitial lung disease after immunosuppressive treatment

Author

Caimmi Cristian, Orsolini Giovanni, Biasi Domenico, Caramaschi Paola, and Festi Giuliana

Subjects
medicine.medical_specialty, Time Factors, Cyclophosphamide, Anti-nuclear antibody, Immunology, Gastroenterology, Pulmonary function testing, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Adrenal Cortex Hormones, Internal medicine, medicine, Humans, Immunology and Allergy, Lung, Aged, 80 and over, 030203 arthritis & rheumatology, business.industry, Remission Induction, Interstitial lung disease, Autoantibody, Recovery of Function, Middle Aged, Mycophenolic Acid, medicine.disease, Connective tissue disease, Treatment Outcome, 030228 respiratory system, Antibodies, Antinuclear, Drug Therapy, Combination, Female, Rituximab, Lung Diseases, Interstitial, business, Biomarkers, Immunosuppressive Agents, medicine.drug, Anti-SSA/Ro autoantibodies
Abstract

The aim of the study was to report three patients affected by interstitial lung disease associated with positive anti-SS-A/Ro autoantibody who showed a dramatic improvement after immunosuppressive treatment. Medical charts were reviewed to obtain clinical data, laboratory parameters, lung function tests, high-resolution computed tomography results and response to immunosuppressive treatment. The three patients showed a clinical picture of a lung-dominant connective tissue disease characterized by a sudden onset with dyspnea, cough and subtle extrathoracic features together with positive anti-SS-A/Ro antibody and weak titer antinuclear antibodies. All three patients responded favorably to immunosuppressive therapy: Two cases were treated with a combination of corticosteroid and cyclophosphamide followed by mycophenolate mofetil; in the third patient, clinical benefit was obtained after rituximab was added to corticosteroid and immunosuppressant drug. In spite of an abrupt onset with significant lung function impairment, all three patients had a favorable clinical response to immunosuppressive therapy. This report may be useful in making therapeutic decisions in case of interstitial lung disease associated with anti-SS-A antibody.

Published
2016

28. Brief Report: Smoking in Systemic Sclerosis: A Longitudinal European Scleroderma Trials and Research Group Study

Author

Jaeger, Veronika K, Valentini, Gabriele, Hachulla, Eric, Cozzi, Franco, Distler, Oliver, Airó, Paolo, Czirják, Laszlo, Allanore, Yannick, Siegert, Elise, Rosato, Edoardo, Matucci-Cerinic, Marco, Caimmi, Cristian, Henes, Jörg, Carreira, Patricia E, Smith, Vanessa, Del Galdo, Francesco, Denton, Christopher P, Ullman, Susanne, De Langhe, Ellen, Riccieri, Valeria, Alegre-Sancho, Juan J, Rednic, Simona, Müller-Ladner, Ulf, Walker, Ulrich A, EUSTAR co-authors, and Chizzolini, Carlo

Subjects
Male, Vital capacity, systemic sclerosis, Vital Capacity, Severity of Illness Index, Scleroderma, 0302 clinical medicine, Forced Expiratory Volume, Immunology and Allergy, DNA Topoisomerases/immunology, Longitudinal Studies, skin and connective tissue diseases, Lung, Skin, ddc:616, Smokers, integumentary system, Smoking, Middle Aged, Disease Progression, Female, Autoantibodies/immunology, Adult, medicine.medical_specialty, Skin/pathology, Immunology, 03 medical and health sciences, FEV1/FVC ratio, Rheumatology, Internal medicine, Severity of illness, medicine, Humans, Adverse effect, Systemic sclerosis, organ manifestations, prevalence, progression, smoking, Autoantibodies, Aged, 030203 arthritis & rheumatology, Scleroderma, Systemic, Heavy smoking, Group study, business.industry, Systemic/immunology/pathology/physiopathology, Lung/physiopathology, Non-Smokers, medicine.disease, respiratory tract diseases, Institutional repository, stomatognathic diseases, Logistic Models, 030228 respiratory system, Linear Models, business, Ex-Smokers, Smoking/immunology/pathology/physiopathology, DNA Topoisomerases
Abstract

ObjectiveMethodsData on the role of tobacco exposure in systemic sclerosis (SSc; scleroderma) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations, based on the European Scleroderma Trials and Research group database. Adult SSc patients with data on smoking history and a 12-24-month follow-up visit were included. Associations of severity and progression of organ involvement with smoking history and the Comprehensive Smoking Index were assessed using multivariable regression analyses. ResultsConclusionA total of 3,319 patients were included (mean age 57 years, 85% female); 66% were never smokers, 23% were ex-smokers, and 11% were current smokers. Current smokers had a lower percentage of antitopoisomerase autoantibodies than previous or never smokers (31% versus 40% and 45%, respectively). Never smokers had a higher baseline forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio than previous and current smokers (P < 0.001). The FEV1/FVC ratio declined faster in current smokers than in never smokers (P = 0.05) or ex-smokers (P = 0.01). The baseline modified Rodnan skin thickness score (MRSS) and the MRSS decline were comparable across smoking groups. Although heavy smoking (>25 pack-years) increased the odds of digital ulcers by almost 50%, there was no robust adverse association of smoking with digital ulcer development. The known adverse effect of smoking on bronchial airways and alveoli is also observed in SSc patients; however, robust adverse effects of smoking on the progression of SSc-specific pulmonary or cutaneous manifestations were not observed.

Published
2018

30. FRI0330 MALIGNANCIES IN SYSTEMIC SCLEROSIS PATIENTSWITH ANTI-PM/SCL ANTIBODIES: AN EUSTAR CASE- CONTROL STUDY

Author

Lazzaroni, Maria Grazia, primary, Zingarelli, Stefania, additional, Vries-Bouwstra, Jeska de, additional, Hachulla, Eric, additional, Zanatta, Elisabetta, additional, Barsotti, Simone, additional, Truchetet, Marie-Elise, additional, Luca, Giacomo De, additional, Smith, Vanessa, additional, Langhe, Ellen De, additional, Hesselstrand, Roger, additional, Ingegnoli, Francesca, additional, Caimmi, Cristian, additional, Randone, Silvia Bellando, additional, Colombo, Enrico, additional, Ceribelli, Angela, additional, Franceschini, Franco, additional, Allanore, Yannick, additional, and Airò, Paolo, additional

Published
2019
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34. AB0761 SECUKINUMAB FOR THE TREATMENT OF PSORIATIC ARTHRITIS IN REAL LIFE: AN ITALIAN EXPERIENCE

Author

Martinis, Federica, primary, Caimmi, Cristian, additional, Foti, Rosario, additional, Visalli, Elisa, additional, Amato, Giorgio, additional, Ramonda, Roberta, additional, Ortolan, Augusta, additional, Lorenzin, Mariagrazia, additional, Semeraro, Angelo, additional, Santo, Leonardo, additional, Praino, Emanuela, additional, Chimenti, Maria Sole, additional, Perricone, Roberto, additional, Sunzini, Favia, additional, Scarpa, Raffaele, additional, Caso, Francesco, additional, Costa, Luisa, additional, Fracassi, Elena, additional, Rossini, Maurizio, additional, and Carletto, Antonio, additional

Published
2019
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35. Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study

Author

Elhai, Muriel, primary, Boubaya, Marouane, additional, Distler, Oliver, additional, Smith, Vanessa, additional, Matucci-Cerinic, Marco, additional, Alegre Sancho, Juan José, additional, Truchetet, Marie-Elise, additional, Braun-Moscovici, Yolanda, additional, Iannone, Florenzo, additional, Novikov, Pavel I, additional, Lescoat, Alain, additional, Siegert, Elise, additional, Castellví, Ivan, additional, Airó, Paolo, additional, Vettori, Serena, additional, De Langhe, Ellen, additional, Hachulla, Eric, additional, Erler, Anne, additional, Ananieva, Lidia, additional, Krusche, Martin, additional, López-Longo, F J, additional, Distler, Jörg H W, additional, Hunzelmann, Nicolas, additional, Hoffmann-Vold, Anna-Maria, additional, Riccieri, Valeria, additional, Hsu, Vivien M, additional, Pozzi, Maria R, additional, Ancuta, Codrina, additional, Rosato, Edoardo, additional, Mihai, Carina, additional, Kuwana, Masataka, additional, Saketkoo, Lesley Ann, additional, Chizzolini, Carlo, additional, Hesselstrand, Roger, additional, Ullman, Susanne, additional, Yavuz, Sule, additional, Rednic, Simona, additional, Caimmi, Cristian, additional, Bloch-Queyrat, Coralie, additional, and Allanore, Yannick, additional

Published
2019
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39. Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis

Author

Ariani, Alarico, primary, Silva, Mario, additional, Bravi, Elena, additional, Parisi, Simone, additional, Saracco, Marta, additional, De Gennaro, Fabio, additional, Caimmi, Cristian, additional, Girelli, Francesco, additional, De Santis, Maria, additional, Volpe, Alessandro, additional, Lumetti, Federica, additional, Hax, Vanessa, additional, Bredemeier, Markus, additional, Alfieri, Veronica, additional, Santilli, Daniele, additional, Bodini, Flavio Cesare, additional, Lucchini, Gianluca, additional, Mozzani, Flavio, additional, Seletti, Valeria, additional, Bacchini, Emanuele, additional, Arrigoni, Eugenio, additional, Giuggioli, Dilia, additional, Chakr, Rafael, additional, Idolazzi, Luca, additional, Bertorelli, Giuseppina, additional, Imberti, Davide, additional, Michieletti, Emanuele, additional, Paolazzi, Giuseppe, additional, Fusaro, Enrico, additional, Chetta, Alfredo Antonio, additional, Scirè, Carlo Alberto, additional, and Sverzellati, Nicola, additional

Published
2019
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40. Effects of Antiangiogenetic Drugs on Microcirculation and Macrocirculation in Patients with Advanced-Stage Renal Cancer

Author

Dalbeni, Andrea, primary, Ciccarese, Chiara, additional, Bevilacqua, Michele, additional, Benati, Marco, additional, Caimmi, Cristian, additional, Cerrito, Luca, additional, Famà, Federico, additional, Iacovelli, Roberto, additional, Mantovani, Anna, additional, Meneguzzi, Francesco, additional, Minuz, Pietro, additional, Montagnana, Martina, additional, Orsolini, Giovanni, additional, Rossini, Maurizio, additional, Tortora, Gianpaolo, additional, Viapiana, Ombretta, additional, and Fava, Cristiano, additional

Published
2018
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44. Rheumatoid arthritis, γδ T cells and bisphosphonates

Author

Rossini, Maurizio, primary, Adami, Giovanni, additional, Viapiana, Ombretta, additional, Idolazzi, Luca, additional, Fassio, Angelo, additional, Giollo, Alessandro, additional, Caimmi, Cristian, additional, Orsolini, Giovanni, additional, and Gatti, Davide, additional

Published
2017
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48. Bone metabolism in patients with anorexia nervosa and amenorrhea

Author

Gatti, Davide, primary, Idolazzi, Luca, additional, el, Ghoch Marwan, additional, Viapiana, Ombretta, additional, Calugi, Simona, additional, Rossini, Maurizio, additional, Caimmi, Cristian, additional, Braga, Vania, additional, Radetti, Giorgio, additional, Adami, Silvano, additional, and Grave, Riccardo Dalle, additional

Published
2016
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49. The initiative on hip fractures of the Veneto Region

Author

Rossini, Maurizio, Caimmi, Cristian, Giannini, Sandro, Sella, Stefania, Mattarei, Alberto, Lovato, Roberto, Piazza, Ilaria, Fassio, Angelo, Persi, Pierluigi, Pier Paolo Benetollo, and Adami, Silvano

Subjects
Original Article, vitamin d, fractures, osteoporosis
Abstract

to assess the prevalence of the most relevant environmental and individual risk factors in subjects with a recent hip fracture was the aim of this observational study promoted by the Health Authorities of the Regione Veneto (Italy).patients aged60 years of both genders with a recent hip fracture not associated with malignancies, were administered questionnaires on dietary habits, sun exposure, disability score. A complete family, pharmacological and pathology history was collected together with previous falls, details of the fracture index, anthropometric data. In a subgroup of patients blood was taken for the measurements of serum 25 hydroxy-vitamin D (25OHD).the study includes 704 patients (573 women and 131 men). Mean age was 81±8 years (range 60-102). Severe pre-fracture disability was a common feature (58%) associated with multiple co-morbidities (84%), more frequently cardiovascular and neurological diseases, and specific medications. In a large proportion (86%) of the patients environmental or individual risk factors for falling were found. Vitamin D insufficiency was quite common, particularly in the regional Health Districts were strategies for preventing vitamin D deficiency were not implemented. Only a small proportion (17%) of the study population had been evaluate and treated for osteoporosis.in senile patients with a recent hip fracture pre-existing disability, multiple co-morbidities, high risk of falling and inadequate intake of calcium and vitamin D was quite common. Community and case-finding interventions are highly warranted.

Published
2012

50. Artrite Reumatoide e Metabolismo Minerale

Author

Rossini, Maurizio, Benini, Camilla, Orsolini, Giovanni, Caimmi, Cristian, Dartizio, Carmela, Fassio, A., Tripi, G., Fracassi, Elena, Viapiana, Ombretta, and Adami, Silvano

Subjects
artrite reumatoide, vitamina D, paratormone
Published
2011

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