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Your search keyword '"Cailleux, A. F."' showing total 29 results
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29 results on '"Cailleux, A. F."'

9. Cytotoxic therapy with etoposide and cisplatin in advanced adrenocortical carcinoma. Réseau Comète INSERM

Author

Bonacci, R., Gigliotti, A., Baudin, E., Wion-Barbot, N., Emy, P., Bonnay, M., Cailleux, A. F., Nakib, I., and Schlumberger, M.

Subjects
Adult, Male, Carcinoma, Middle Aged, Adrenal Cortex Neoplasms, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Mitotane, Cisplatin, Research Article, Aged, Etoposide
Abstract

Adrenocortical carcinoma (ACC) is a rare tumour with a poor prognosis. Cisplatin is the most widely tested cytotoxic agent in this disease. A total of 18 patients with advanced ACC were enrolled. Cytotoxic therapy consisted of etoposide (VP16) (100 mg m(-2) day(-1) on days 1-3) and cisplatin (100 mg m(-2) day(-1) on day 1) every 4 weeks. Mitotane treatment was maintained during chemotherapy in 14 patients. A complete response was observed in three cases and a partial response in three cases, giving an overall response rate of 33%. Tumour response was observed in three of the six patients with progressive disease during treatment with mitotane given at an effective dosage, as shown by serum levels >14 mg l(-1). Toxic effects were as expected and were non-life-threatening; no treatment interruption was required.

Published
1998

10. L-Lysine Acts as a Serotonin Type 4 Receptor Antagonist to Counteract In Vitro and In Vivo the Stimulatory Effect of Serotonergic Agents on Aldosterone Secretion in Man.

Author

Duparc, C., André, C., Ménard, J. F., Godouet-Getti, B., Wils, J., Cailleux, A. F., Moreau-Grangé, L., Louiset, E., and Lefebvre, H.

Subjects
LYSINE, SEROTONIN receptors, ALDOSTERONE, ADRENAL diseases, PLACEBOS
Abstract

In the normal human adrenal gland, serotonin (5-HT) stimulates aldosterone secretion through the 5-HT4 receptor (5-HT4R). However, the physiological role of the serotonergic control of adrenocortical function is not known. In the present study, we have investigated the ability of l-Lysine, which has been shown to act as a 5-HT4 receptor antagonist, to counteract in vitro and in vivo the stimulatory effect of 5-HT4R agonists on aldosterone production. l-Lysine was found to inhibit aldosterone production induced by 5-HT and the 5-HT4R agonists BIMU8 from cultured human adrenocortical cells. The action of l-Lysine (4.95 g/day orally) on the adrenal cortex was also evaluated in 20 healthy volunteers in a double blind, cross-over, placebo controlled study. l-Lysine had no significant influence on basal plasma aldosterone levels and the aldosterone responses to upright posture, tetracosactide, and low sodium diet (10 mmol/day for 3 days). Conversely, l-Lysine significantly reduced the surge of plasma aldosterone induced by metoclopramide indicating that l-Lysine is able to efficiently antagonize the adrenal 5-HT4 receptors in vivo. These results suggest that l-lysine supplementation may represent a new treatment of primary adrenal diseases in which corticosteroid hypersecretion is driven by overexpressed 5-HT4 receptors. [ABSTRACT FROM AUTHOR]

Published
2017
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11. Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature

Author

Marie, I., primary, Gehanno, J.-F., additional, Bubenheim, M., additional, Duval-Modeste, A.-B., additional, Joly, P., additional, Dominique, S., additional, Bravard, P., additional, Noël, D., additional, Cailleux, A.-F., additional, Weber, J., additional, Lagoutte, P., additional, Benichou, J., additional, and Levesque, H., additional

Published
2014
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28. Thyroid cancer after radiation exposure.

Author

Rubino C, Cailleux AF, De Vathaire F, and Schlumberger M

Subjects
Cell Transformation, Neoplastic genetics, Child, Child, Preschool, Female, Humans, Infant, Male, Neoplasms, Radiation-Induced epidemiology, Neoplasms, Radiation-Induced therapy, Radioactive Hazard Release, Thyroid Neoplasms epidemiology, Thyroid Neoplasms therapy, Ukraine epidemiology, Neoplasms, Radiation-Induced etiology, Thyroid Neoplasms etiology
Published
2002
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29. [Neuro-endocrine tumors and von Hippel-Lindau disease. 3 cases].

Author

Aubert-Petit G, Baudin E, Cailleux AF, Pellegriti G, Elias D, Travagli JP, Giraud S, Richard S, and Schlumberger M

Subjects
Adolescent, Adrenal Gland Neoplasms complications, Adrenal Gland Neoplasms diagnostic imaging, Adult, Child, Humans, Magnetic Resonance Imaging, Male, Pancreatic Neoplasms complications, Pancreatic Neoplasms diagnostic imaging, Pedigree, Pheochromocytoma diagnosis, Pheochromocytoma etiology, Ultrasonography, von Hippel-Lindau Disease genetics, von Hippel-Lindau Disease complications
Abstract

Background: Neuroendocrine tumors can occur in patients with hereditary syndromes predisposing to multiple endocrine neoplasia (MEN) and Von Hippel-Lindau disease (VHL)., Case Reports: We report the cases of three men with pheochromocytomas, one with an associated neuroendocrine tumor of the pancreas. In one case, diagnosis was suggested by the familial context of VHL in the patients father. In the two other cases, the bilateral character of the pheochromocytoma, and in one case the associated pancreatic neuroendocrine tumor led to the diagnosis of VHL. Systematic biological surveillance gave the diagnosis of contralateral pheochromocytoma in two cases. Search for associated tumoral lesions led to the diagnosis of hemangioblastoma of the cerebellum in two patients and pancreatic cyst in the third. No renal or retinal lesions were observed. Molecular study of the VHL gene evidenced point nonsense mutation of the gene in all three patients, involving codon 184 in two and codon 167 in the third (identical to the proband case). Systematic investigations in the families of the two other patients remains to be completed., Conclusion: The diagnosis of HVL disease should be suggested in case of familial pheochromocytoma and/or bilateral localizations, but also in case of neuroendocrine tumors of the pancreas associated with another cardinal lesion of the disease. Early screening and treatment of this potentially fatal disease is essential.

Published
1999

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