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462 results on '"Caillard, S."'

1. COVID-19 et transplantation d’organes, les leçons du recensement national de la Société francophone de transplantation

Author

Caillard, S., Moulin, B., Fafi-Kremer, S., Hazzan, M., Anglicheau, D., Hertig, A., Tourret, J., Barrou, B., Morelon, E., Thaunat, O., Couzi, L., Merville, P., Moal, V., Legris, T., Westeel, P.-F., Jaureguy, M., Frimat, L., Ducloux, D., Bamoulid, J., Bertrand, D., Tsimaratos, M., Garaix-Gilardo, F., Dumortier, J., Mussot, S., Roux, A., Sebbag, L., Le Meur, Y., Blancho, G., Masset, C., Kamar, N., Francois, H., Rondeau, E., Bouvier, N., Mousson, C., Buchler, M., Gatault, P., Augusto, J.-F., Duveau, A., Vigneau, C., Morin, M.-C., Chemouny, J., Golbin, L., Grimbert, P., Matignon, M., Durrbach, A., Greze, C., Snanoudj, R., Colosio, C., Schvartz, B., Malvezzi, P., Mariat, C., Thierry, A., Le Quintrec, M., Sicard, A., Rerolle, J.P., Heng, A.-É., Garrouste, C., Coponat, H.V., Epailly, É., Brugiere, O., Dharancy, S., Salame, É., Saliba, F., and Caillard, Sophie

Published
2022
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2. Global Transplantation COVID Report March 2020

Author

Ahn, C., Amer, H., Anglicheau, D., Ascher, N.L., Baan, C.C., Battsetset, G., Bat-Ireedui, B., Berney, T., Betjes, M.G.H., Bichu, S., Birn, H., Brennan, D., Bromberg, J., Caillard, S., Cannon, R.M., Cantarovich, M., Chan, A., Chen, Z.S., Chapman, J.R., Cole, E.H., Cross, N., Durand, F., Egawa, H., Emond, J.C., Farrero, M., Friend, P.J., Geissler, E.K., Ha, J., Haberal, M.A., Henderson, M.L., Hesselink, D.A., Humar, A., Jassem, W., Jeong, J.C., Kaplan, B., Kee, T., Kim, S.J., Kumar, D., Legendre, C.M., Man, K., Moulin, B., Muller, E., Munkhbat, R., Od-Erdene, L., Perrin, P., Rela, M., Tanabe, K., Tedesco Silva, H., Tinckam, K.T., Tullius, S.G., and Wong, G.

Published
2020
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44. An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides

Author

Domingo-Calap P, Schubert B, Joly M, Solis M, Untrau M, Carapito R, Georgel P, Caillard S, Fafi-Kremer S, Paul N, Kohlbacher O, González-Candelas F, and Bahram S

Subjects
viruses
Abstract

Infection with human BK polyomavirus, a small double-stranded DNA virus, potentially results in severe complications in immunocompromised patients. Here, we describe the in vivo variability and evolution of the BK polyomavirus by deep sequencing. Our data reveal the highest genomic evolutionary rate described in double-stranded DNA viruses, i.e., 10(-3)-10(-5) substitutions per nucleotide site per year. High mutation rates in viruses allow their escape from immune surveillance and adaptation to new hosts. By combining mutational landscapes across viral genomes with in silico prediction of viral peptides, we demonstrate the presence of significantly more coding substitutions within predicted cognate HLA-C-bound viral peptides than outside. This finding suggests a role for HLA-C in antiviral immunity, perhaps through the action of killer cell immunoglobulin-like receptors. The present study provides a comprehensive view of viral evolution and immune escape in a DNA virus.

Published
2018

49. Cytokine release syndrome‐associated encephalopathy in patients with COVID‐19.

Author

Perrin, P., Collongues, N., Baloglu, S., Bedo, D., Bassand, X., Lavaux, T., Gautier‐Vargas, G., Keller, N., Kremer, S., Fafi‐Kremer, S., Moulin, B., Benotmane, I., and Caillard, S.

Subjects
COVID-19, CYTOKINE release syndrome, INTRAVENOUS immunoglobulins, CHIMERIC antigen receptors, BRAIN diseases
Abstract

Background and purpose: Neurological manifestations in coronavirus disease (COVID)‐2019 may adversely affect clinical outcomes. Severe COVID‐19 and uremia are risk factors for neurological complications. However, the lack of insight into their pathogenesis, particularly with respect to the role of the cytokine release syndrome (CRS), is currently hampering effective therapeutic interventions. The aims of this study were to describe the neurological manifestations of patients with COVID‐19 and to gain pathophysiological insights with respect to CRS. Methods: In this longitudinal study, we performed extensive clinical, laboratory and imaging phenotyping in five patients admitted to our renal unit. Results: Neurological presentation included confusion, tremor, cerebellar ataxia, behavioral alterations, aphasia, pyramidal syndrome, coma, cranial nerve palsy, dysautonomia, and central hypothyroidism. Notably, neurological disturbances were accompanied by laboratory evidence of CRS. Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) was undetectable in the cerebrospinal fluid (CSF). Hyperalbuminorrachia and increased levels of the astroglial protein S100B were suggestive of blood−brain barrier (BBB) dysfunction. Brain magnetic resonance imaging findings comprised evidence of acute leukoencephalitis (n = 3, one of whom had a hemorrhagic form), cytotoxic edema mimicking ischaemic stroke (n = 1), or normal results (n = 2). Treatment with corticosteroids and/or intravenous immunoglobulins was attempted, resulting in rapid recovery from neurological disturbances in two cases. SARS‐CoV2 was undetectable in 88 of the 90 patients with COVID‐19 who underwent Reverse Transcription‐PCR testing of CSF. Conclusions: Patients with COVID‐19 can develop neurological manifestations that share clinical, laboratory and imaging similarities with those of chimeric antigen receptor T‐cell‐related encephalopathy. The pathophysiological underpinnings appear to involve CRS, endothelial activation, BBB dysfunction, and immune‐mediated mechanisms. [ABSTRACT FROM AUTHOR]

Published
2021
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