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Platelet over-activation is one of the important mechanisms of atherosclerosis （AS） in diabetes mellitus. Dietary nutrient intervention plays an important role in the primary prevention and treatment of diabetes mellitus combined with AS. Studies have shown that the antiplatelet factor in tomato extract can inhibit platelet aggregation and activation in different environments. Its bioactive ingredient are nucleosides and derivatives and phenolic compounds， which retard the pathological progress of diabetes mellitus complicated with AS. This review aims to explore the mechanism of the antiplatelet effect of tomato extract， and to provide a theoretical basis for the prevention and treatment of diabetes mellitus complicated with AS.

Objective To explore the role and underlying mechanism of C1q/TNF-related protein 6 (CTRP6) in the development process of liver disease. Methods The histopathological examination and biochemical indexes of injured livers from wild-type (CTRP6+/+) and knockout (CTRP6-/-) mice induced by intragastric administration of CCl4 were analyzed. RT-qPCR was used to detect the expression of the fibrosis marker genes (Acta2, Col1al, Mmp2 and TGF-β) and cell proliferation marker genes (Cyclin D, Cyclin E and CDK6). Results Compared with CTRP6+/+ mice, the hepatocytes in CTRP6-/- mice showed mild necrosis, looseness and swelling. The high SOD activity and low MDA level were also observed in CTRP6-/- mice liver. Meanwhile, the expression of fibrosis and cell proliferation markers in CTRP6-/- mice were significantly lower than those in CTRP6+/+ mice. Conclusions CTRP6 gene is closely related to liver disease development, and the liver fibrosis progression induced by CCl4 is alleviated by its deletion. The mechanism may be explained as that CTRP6 knockout affects the proliferative capacity of hepatocytes.

Over the last thirty to forty years, as technology and supplementary broadcast networks have advanced, an increasing number of teachers have entered the classroom with new perspectives, such as providing students with resources and an environment that adheres to the blended teaching style. Learning can take place whenever and wherever it is desired with a blended teaching approach. The primary goal of this study was to investigate whether the blended teaching strategies and materials or the traditional teaching method in the Business English class increase students' learning satisfaction and academic achievement. Participants in this study included 56 undergraduate students majoring in Applied Foreign Languages in central Taiwan. Business English ESP courses were offered during the 108 and 109 academic years. The four-point Likert scale questionnaire was distributed after students took the course. Moreover, in-person interviews and class observations were also focused to reveal overall students' learning efficiency and perceptions on the preferences of teaching techniques in Business English and their learning satisfaction. As a result, students considered blended teaching an effective teaching strategy that increased their learning motivation with additional instructional activities. In addition, findings demonstrated that both handwritten exams (associated with traditional teaching methods) and interactive answering Apps (associated with blended teaching methods) work effectively based on different teaching methods. The outcomes of this study suggest that the majority of students have a positive attitude toward blended learning in the ESP program of business English and that their academic performance has obviously improved.

A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC50 value of 0.54 ± 0.01 ppm.

Learning business related courses, especially accounting, in English is a challenge for many Chinese students. The purpose of this study is to provide some insights into the role of the language in accounting learning. We investigate this issue in the program of Teaching Business Related Courses in English for undergraduate students at Guangdong University of Foreign Studies. Accounting courses in English at GDUFS are taught to two different groups: English majors with higher English proficiency who are required to receive 2 years of intensive training in listening, speaking, reading and writing before taking the accounting course in English and non-English majors who do not receive the same level of English training as English majors do. We find that there is no direct significant relationship between accounting learning and students' English proficiency but we do find a strong correlation between students' analytical ability and their accounting learning instructed in English. We also find that motivation, specifically students' clear career path in the accounting field, plays an important role in determining their performance in accounting learning. The findings in this paper have meaningful implications for the feasibility of teaching non-English majors accounting in English and for designing a good learning environment in English educational settings.

Lung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia- inducible transcription factors (HIFs), but growing evidence indicates that transcriptional programs beyond HIFs control tumor angiogenesis. Here, we show that the redox-sensitive transcription factor BTB and CNC homology 1 (BACH1) controls the transcription of a broad range of angiogenesis genes. BACH1 is stabilized by lowering ROS levels; consequently, angiogenesis gene expression in lung cancer cells, tumor organoids, and xenograft tumors increased substantially following administration of vitamins C and E and N-acetylcysteine in a BACH1-dependent fashion under normoxia. Moreover, angiogenesis gene expression increased in endogenous BACH1-overexpressing cells and decreased in SACH7-knockout cells in the absence of antioxidants. BACH1 levels also increased upon hypoxia and following administration of prolyl hydroxylase inhibitors in both HfF7A-knockout and WT cells. BACH1 was found to be a transcriptional target of HIF1[alpha], but BACH1's ability to stimulate angiogenesis gene expression was HIF1[alpha] independent. Antioxidants increased tumor vascularity in vivo in a BACH1- dependent fashion, and overexpressing BACH1 rendered tumors sensitive to antiangiogenesis therapy. BACH1 expression in tumor sections from patients with lung cancer correlated with angiogenesis gene and protein expression. We conclude that BACH1 is an oxygen- and redox-sensitive angiogenesis transcription factor., Introduction Lung tumor growth and metastasis requires angiogenesis--the formation of new blood vessels (1, 2). Angiogenesis is typically triggered by hypoxia, which stabilizes hypoxia-inducible transcription factors (HIFs) including HIF1[alpha] and [...]

The bond–slip behavior of concrete pile–cemented soil interface is crucial for load transfer analysis of stiffened deep cement mixing piles, which is greatly influenced by ground temperature and age during long-term curing. However, the thermal–temporal effect on the frictional characteristics of this interface remains unclear. In this paper, an element-scale specimen of concrete pile–cemented soil interface was first designed. Then interfacial shear tests were performed on batches of samples subjected to varied curing temperatures (T) and ages (t) to obtain interfacial bond–slip (τ‒s) curves. The test results showed that the interfacial peak shear strength (τu) increased with the growth of T and t. Based on the experimental observations, a strength development model for τu considering the thermal effect was established. Subsequently, a disturbed state concept (DSC)-based constitutive model incorporating the thermal–temporal effect was proposed for the investigated interface. Both prepeak and postpeak stages of the τ‒s curves can be effectively described by the developed DSC model, exhibiting robust performance in fitting and predicting experimental results. Finally, the DSC model was cross-validated by the interfacial τ‒s data sets collected from reported experimental publications. Across all data sets, the coefficient of determination (R2) exceeded 0.9, and the mean absolute percentage error of τu remained below 10% when comparing predictions with measurements, which strongly highlights the generalization capability of the DSC model. [ABSTRACT FROM AUTHOR]

The experiment aims to determine the nutritional components of reed mushroom foot waste and evaluate its nutritional value. The conventional feed nutrient determination method was used to measure the content of crude protein, crude fat, moisture, crude ash, and main trace elements in reed mushroom foot waste. The internationally accepted non-biological evaluation method was used to assess the nutritional value of protein. The results showed that the reed mushroom foot waste contained 24.76% crude protein, 0.29% crude fat, 11.78% moisture and 7.46% crude ash, the content of main mineral elements in reed mushroom foot waste was Cu 57 mg/kg, Fe 212 mg/kg, Mn 31 mg/kg and Zn 66 mg/kg. A total of 17 kinds of amino acids were detected in reed mushroom foot waste. The ratio of essential amino acids (EAA) to the total amino acids (TAA) was 0.40, and the ratio of non-essential amino acids (NEAA) to TAA was 0.60. The results of AAS showed that the first limiting amino acid was valine, the second limiting amino acid was methionine, and the third limiting amino acid was methionine + cystine. The EAARR score of reed mushroom foot waste was 66.5%, and the GRG method score was 0.78. The study indicates that reed mushroom foot waste can be used as a high quality protein feed raw material, which has the value of development and application. [ABSTRACT FROM AUTHOR]

Accurate and sensitive near‐infrared (NIR) luminescent lateral flow immunoassay (LFIA) has attracted considerable attention in the field of point‐of‐care testing (POCT). However, the detection accuracy and sensitivity are often compromised by the low fluorescence quantum efficiency (<10%) of the NIR fluorescent probe. Herein, ultrabright NIR AIEgen nanoparticles (PS@AIE830NPs) composed of polystyrene (PS) nanoparticles and NIR aggregation‐induced emission luminogen (AIEgen) with the maximum emission at 830 nm (AIE830) is reported, and its potential to promote an accurate and sensitive detection of complex samples by LFIA is described. The relative quantum yield (QY) of the PS@AIE830NPs was 14.76%, which was superior to that of the polymer embedding method and indocyanine green (ICG)‐based NIR nanoparticles. The PS@AIE830NPs immunolabeled‐LFIA combined with laboratory‐built NIR‐LFIA portable quantitative instruments (detected light range > 800 nm) completely eliminated background interference and allowed highly accurate and sensitive detection without any pre‐treatment steps. The limits of detection (LODs) for aflatoxin B1 (AFB1) in soy sauce, alpha hemolysin (Hla) of Staphylococcus aureus biomarker in joint fluid, and C‐reactive protein (CRP) in human haemolysed samples were 0.01 ng mL−1, 0.02 µg mL−1, and 0.156 mg L−1, respectively, commensurating with those of the corresponding gold standard assays and covering the detection range of interests. It is anticipated that the ultrabright NIR AIEgen nanoparticles will serve as a universally applicable signal probe for NIR‐LFIA diagnostics, promising to expand the range of applications for quantitative detection of complex samples. [ABSTRACT FROM AUTHOR]