Search

Your search keyword '"Cai, Wei-Meng"' showing total 4 results
Start Over Author "Cai, Wei-Meng"
4 results on '"Cai, Wei-Meng"'

2. Effect of Continuous Positive Airway Pressure on Incident Frailty in Elderly Patients with Obstructive Sleep Apnea: A Study Based on Propensity Score Matching

Author

Xue,Xin, Zhao,Li-Bo, Zhao,Zhe, Xu,Wei-Hao, Cai,Wei-Meng, Chen,Shao-Hua, Li,Tian-Jiao, Nie,Ting-Yu, Rui,Dong, Qian,Xiao-Shun, Liu,Lin, Xue,Xin, Zhao,Li-Bo, Zhao,Zhe, Xu,Wei-Hao, Cai,Wei-Meng, Chen,Shao-Hua, Li,Tian-Jiao, Nie,Ting-Yu, Rui,Dong, Qian,Xiao-Shun, and Liu,Lin

Abstract

Xin Xue,1,2 Li-Bo Zhao,3 Zhe Zhao,3 Wei-Hao Xu,4 Wei-Meng Cai,1 Shao-Hua Chen,1 Tian-Jiao Li,5 Ting-Yu Nie,5 Dong Rui,1 Xiao-Shun Qian,1 Lin Liu1 1Department of Pulmonary and Critical Care Medicine, Second Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; 3Department of Vasculocardiology, Second Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Geriatrics, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China; 5Medical College, Yan’ an University, Yan’ an, People’s Republic of ChinaCorrespondence: Lin Liu; Xiao-Shun Qian, Department of Pulmonary and Critical Care Medicine, Second Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China, Tel +86 132 6318 9578 ; +86 135 2127 9287, Email liulin715@qq.com; 13521279287@163.comBackground: The concomitant rise in the prevalence of obstructive sleep apnea (OSA) and frailty among the elderly population has been linked to an increase in mortality rates. Despite continuous positive airway pressure (CPAP) being the gold standard treatment for OSA, its impact on incident frailty remains inadequately explored.Methods: In this cohort study, we analyzed data from 1290 patients diagnosed with OSA, aged 60 years and older. A subset of 71 patients who demonstrated high adherence to CPAP therapy were categorized as the CPAP group. Propensity score matching (PSM) was employed at a 1:4 ratio, matching for variables such as age, gender, body mass index (BMI), and sleep apnea-hypopnea index (AHI), to establish a non-CPAP group for comparison. The FRAIL scale was utilized to evaluate the frailty status of participants. Logistic regression analysis examined

Published
2024

4. Gut microbiota changes in healthy individuals, obstructive sleep apnea patients, and patients treated using continuous positive airway pressure: a whole-genome metagenomic analysis.

Author

Xue X, Zhao Z, Zhao LB, Gao YH, Xu WH, Cai WM, Chen SH, Li TJ, Nie TY, Rui D, Ma Y, Qian XS, Lin JL, and Liu L

Subjects
Humans, Male, Middle Aged, Female, Adult, Polysomnography, Continuous Positive Airway Pressure, Sleep Apnea, Obstructive therapy, Sleep Apnea, Obstructive microbiology, Gastrointestinal Microbiome physiology, Gastrointestinal Microbiome genetics, Metagenomics
Abstract

Purpose: This study investigated variations in gut microbiota among severe obstructive sleep apnea (OSA) patients and changes in gut microbiota after continuous positive airway pressure (CPAP) treatment., Method: From November 2020 to August 2021, laboratory-based polysomnography (PSG) was used to measure sleep parameters in healthy controls, severe OSA patients, and severe OSA patients treated with CPAP for three months. A fully automated biochemical analyzer was used to evaluate routine blood tests and biochemical indicators. Whole-genome metagenomic analysis was used to determine the microbial composition of gut samples from all participants. The relationships between gut microbiota and hypertension were examined using correlation analysis., Result: The relative abundances of Bacteroides, Firmicutes, and Parabacteroides were significantly lower at the species level. Enterobacterales and Turicibacter were significantly higher in participants with severe OSA than healthy controls. Negative correlations were identified between Bacteroides coprocola and systolic blood pressure (SBP) (r =  - 0.710, P = 0.003) and diastolic blood pressure (DBP) (r =  - 0.615, P = 0.015). Conversely, a positive correlation was found between Escherichia coli and SBP (r = 0.568, P = 0.027)., Conclusion: The metabolic pathways and gut microbiota differed significantly between the control group and individuals with severe OSA. Additionally, CPAP therapy substantially changed the metabolic pathways and gut microbial composition among patients diagnosed with severe OSA. Correlation analysis further revealed a strong association between Escherichia coli, Bacteroides coprocola, and blood pressure levels., Competing Interests: Declarations. Ethics approval and consent to participate: The research was carried out in alignment with the principles outlined in the Declaration of Helsinki and received approval from the Ethics Committee of the PLA General Hospital (S2020-397–02). Conflict of interest: There are no potential conflicts of interest regarding this study., (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results