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182 results on '"Cai, Hong-Yan"'

22. Pathological Mechanism and Targeted Drugs of COPD

Author

Guo,Peng, Li,Rui, Piao,Tie Hua, Wang,Chun Lan, Wu,Xiao Lu, and Cai,Hong Yan

Subjects
International Journal of Chronic Obstructive Pulmonary Disease
Abstract

Peng Guo,1 Rui Li,2 Tie Hua Piao,3 Chun Lan Wang,3 Xiao Lu Wu,3 Hong Yan Cai3 1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Changchun, 130000, People’s Republic of China; 2Graduate School, Beijing University of Chinese Medicine, Beijing, 100000, People’s Republic of China; 3Pulmonology Department, The First Clinical Hospital of Jilin Academy of Traditional Chinese Medicine, Changchun, 130000, People’s Republic of ChinaCorrespondence: Hong Yan Cai, The First Clinical Hospital of Jilin Academy of Traditional Chinese Medicine, Changchun, 130000, People’s Republic of China, Email 774009408@qq.comAbstract: Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis, emphysema, and small airway obstruction. Incompletely reversible airflow limitation, inflammation, excessive mucus secretion and bronchial mucosal epithelial lesions are the main pathological basis of the disease. The prevalence of COPD is increasingly worldwide, which has caused the burden on individuals and society. This paper summarizes the pathogenesis of COPD and clarifies the effect and mechanism of the latest targeted drugs for COPD. Besides, we focus on NOD-like receptor thermal protein domain associated protein 3 inflammasome (NLRP3 inflammasome). NLRP3 can promote production of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3 is an important factor in the migratory aggregation of macrophages and neutrophils and the generation of oxidative stress. Inhibition of NLRP3 inflammasome indirectly blocks the inflammatory effects of IL-1β and IL-18, which may be regarded as an ideal target for COPD treatment.Keywords: chronic obstructive pulmonary disease, pathogenesis, targeted drugs, NLRP3

Published
2022

24. (D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer’s disease transgenic mice

Author

Qi, Jin-Shun, primary, Wang, Zhao-Jun, primary, Yang, Guang-Zhao, additional, Gao, Qi-Chao, additional, Li, Wei-Ran, additional, Cai, Hong-Yan, additional, Zhao, Hui-Min, additional, Wang, Jian-Ji, additional, Zhao, Xin-Rui, additional, Wang, Jia-Xin, additional, Wu, Mei-Na, additional, Zhang, Jun, additional, and Hölscher, Christian, additional

Published
2022
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27. DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Upregulating cAMP/PKA/CREB Signaling Pathways

Author

Yuan, Li, primary, Zhang, Jun, additional, Guo, Jun-Hong, additional, Holscher, Christian, additional, Yang, Jun-Ting, additional, Wu, Mei-Na, additional, Wang, Zhao-Jun, additional, Cai, Hong-Yan, additional, Han, Ling-Na, additional, Shi, Hui, additional, Han, Yu-Fei, additional, and Qi, Jin-Shun, additional

Published
2021
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44. A modified regimen of extracorporeal cardiac shock wave therapy for treatment of coronary artery disease

Author

Wang Yu, Guo Tao, Ma Tie-kun, Cai Hong-yan, Tao Si-ming, Peng Yun-zhu, Yang Ping, Chen Ming-qing, and Gu Yun

Subjects
Coronary artery disease, Angina pectoris, Myocardial ischemia, Cardiac shock wave therapy, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Cardiac shock wave therapy (CSWT) improves cardiac function in patients with severe coronary artery disease (CAD). We aimed to evaluate the clinical outcomes of a new CSWT treatment regimen. Methods The 55 patients with severe CAD were randomly divided into 3 treatment groups. The control group (n = 14) received only medical therapy. In group A ( n = 20), CSWT was performed 3 times within 3 months. In group B ( n = 21), patients underwent 3 CSWT sessions/week, and 9 treatment sessions were completed within 1 month. Primary outcome measurement was 6-minute walk test (6MWT). Other measurements were also evaluated. Results The 6MWT, CCS grading of angina, dosage of nitroglycerin, NYHA classification, and SAQ scores were improved in group A and B compared to control group. Conclusions A CSWT protocol with 1 month treatment duration showed similar therapeutic efficacy compared to a protocol of 3 months duration. Clinical trial registry We have registered on ClinicalTrials.gov, the protocol ID is CSWT IN CHINA.

Published
2012
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45. Association between circulating 25‐hydroxyvitamin D and systemic lupus erythematosus: A systematic review and meta‐analysis

Author

Guan, Shi‐Yang, primary, Cai, Hong‐Yan, additional, Wang, Peng, additional, Lv, Tian‐Tian, additional, Liu, Li‐Na, additional, Mao, Yan‐Mei, additional, Zhao, Chan‐Na, additional, Wu, Qian, additional, Dan, Yi‐Lin, additional, Sam, Napoleon Bellua, additional, Wang, De‐Guang, additional, and Pan, Hai‐Feng, additional

Published
2019
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47. Interfacial dilational properties of betaines and sulfonate mixtures: Effects of alkyl chain length.

Author

Zhang, Yi, Cai, Hong-Yan, Hu, Song-Shuang, Li, Jian-Guo, Gong, Qing-Tao, Ma, Wang-Jing, Liu, Zi-Yu, Zhang, Lei, Zhang, Lu, and Zhao, Sui

Subjects
*BETAINE, *MOLECULAR structure, *MIXTURES, *SULFONATES, *SURFACE active agents
Abstract

The dilational rheological properties of anionic/zwitterionic surfactant mixtures of sodium dialkyl sulfosucciantes (SNN10) and three betaines (SB12, SB14 and SB16) have been measured by means of a drop shape analysis method. It is established that SNN10 shows high interfacial activity due to tighter packing of the hydrophobic chains and the film properties of SNN10 is dominated by the in-interface process. When betaines and SNN10 are purposely mixed, the SNN10 molecule would be likely to displace the betaines molecule at the interface, and the displacement depends on the molecular structure of betaines: the shorter the hydrophobic chain, the easier it is to be replaced. In addition, adding SB16 to SNN10 would increase strength of the interfacial film at high surfactant concentrations. [ABSTRACT FROM AUTHOR]

Published
2020
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