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374 results on '"Cai, Guang-Yan"'

8. Risk factors for intracerebral hemorrhage in patients undergoing maintenance hemodialysis

Author

Song Yu-Huan, Cai Guang-Yan, and Xiao Yue-Fei

Subjects
intracerebral hemorrhage, hemodialysis, parathyroid hormone, risk factor, secondary hyperparathyroidism, Neurology. Diseases of the nervous system, RC346-429
Abstract

BackgroundIn patients undergoing hemodialysis, intracerebral hemorrhage (ICH) is the main cause of mortality among stroke subtypes. It is unclear whether, along with traditional cardiovascular risk factors, the risk factors unique to the uraemic environment, such as the abnormal metabolism of intact parathyroid hormone (iPTH), can contribute to the risk of ICH in these patients.MethodsThis retrospective case–control study included 25 patients undergoing hemodialysis with ICH at a single center between 30 June 2015 and 10 October 2022. The controls were 95 patients undergoing maintenance hemodialysis treated at the same dialysis center in July 2020. We compared the characteristics of patients with ICH with those of the control group to identify factors that contributed to the development of ICH.ResultsIntracerebral hemorrhage (ICH) was located in the basal ganglia (14/25), cerebellum (6/25), and brainstem (6/25) in 25 patients. A total of 17 patients died in the first 16 days due to neurological complications. Univariate analysis showed significant differences in systolic BP, diastolic BP, iPTH, and alkaline phosphatase between the two groups (p

Published
2023
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11. Nephrology in China

Author

Wang, Angela Yee-Moon, An, Yu, Cai, Guang-Yan, Chen, Jiang-Hua, Chen, Wei, Chen, Xiang-Mei, Cui, Zhao, Hao, Chuan-Ming, Hou, Fan-Fan, Liu, Bi-Cheng, Liu, Zhi-Hong, Niu, Qing-Yu, Sun, Qi-Quan, Wang, Ren-Ding, Xu, Damin, Yang, Chao, Yang, Li, Zhang, Luxia, Zhao, Ming-Hui, Zuo, Li, Yu, Xue-Qing, Moura-Neto, José A., editor, Divino-Filho, José Carolino, editor, and Ronco, Claudio, editor

Published
2021
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13. Efficacy and safety of Shenyankangfu Tablet, a Chinese patent medicine, for primary glomerulonephritis: A multicenter randomized controlled trial

Author

Wu, Jie, Duan, Shu-wei, Yang, Hong-tao, Deng, Yue-yi, Li, Wei, He, Ya-ni, Ni, Zhao-hui, Zhan, Yong-li, Lin, Shan, Guo, Zhi-yong, Zhu, Jun, Fang, Jing-ai, Liu, Xu-sheng, Wang, Li-hua, Wang, Rong, Wang, Nian-song, Cheng, Xiao-hong, He, Li-qun, Luo, Ping, Sun, Shi-ren, Sun, Ji-feng, Yin, Ai-ping, Jiang, Geng-ru, Chen, Hong-yu, Liu, Wen-hu, Lin, Hong-li, Liang, Meng, Ma, Lu, Chen, Ming, Song, Li-qun, Chen, Jian, Zhu, Qing, Xing, Chang-ying, Li, Yun, Gao, Ji-ning, Li, Rong-shan, Li, Ying, Zhang, Hao, Lu, Ying, Zhou, Qiao-ling, Fu, Jun-zhou, He, Qiang, Cai, Guang-yan, and Chen, Xiang-mei

Published
2021
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15. Local Renal Treatments for Acute Kidney Injury: A Review of Current Progress and Future Translational Opportunities.

Author

Chen, Yu-Hao, Xiao, Tuo, Zheng, Xu-Min, Xu, Yue, Zhuang, Kai-Ting, Wang, Wen-Juan, Chen, Xiang-Mei, Hong, Quan, and Cai, Guang-Yan

Subjects
ACUTE kidney failure, KIDNEY diseases, TECHNOLOGICAL innovations, RENAL artery, INTRAVENOUS therapy, THERAPEUTICS
Abstract

Acute kidney injury (AKI) constitutes a significant public health concern, with limited therapeutic options to mitigate injury or expedite recovery. A novel therapeutic approach, local renal treatment, encompassing pharmacotherapy and surgical interventions, has exhibited positive outcomes in AKI management. Peri-renal administration, employing various delivery routes, such as the renal artery, intrarenal, and subcapsular sites, has demonstrated superiority over peripheral intravenous infusion. This review evaluates different drug delivery methods, analyzing their benefits and limitations, and proposes potential improvements. Renal decapsulation, particularly with the availability of minimally invasive techniques, emerges as an effective procedure warranting renewed consideration for AKI treatment. The potential synergistic effects of combined drug delivery and renal decapsulation could further advance AKI therapies. Clinical studies have already begun to leverage the benefits of local renal treatments, and with ongoing technological advancements, these modalities are expected to increasingly outperform systemic intravenous therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Effects of Niaoduqing Particles (尿毒清颗粒) on Delaying Progression of Renal Dysfunction: A Post-trial, Open-Label, Follow-up Study

Author

Zheng, Ying, Wang, Nian-song, Liu, Yu-ning, He, Li-qun, Jian, Gui-hua, Liu, Xu-sheng, Ni, Zhao-hui, Cheng, Xiao-hong, Lin, Hong-li, Zhou, Wen-hua, Wang, Ya-ping, Fang, Jing-ai, He, Ya-ni, Yang, Hong-tao, Zhao, Li-juan, Ding, Han-lu, Wang, Li-hua, Yu, Ren-huan, Li, Wen-ge, Ye, Zhi-ming, Guo, Wang, Zhan, Yong-li, Mao, Hui-juan, Hu, Zhao, Yao, Chen, Cai, Guang-yan, and Chen, Xiang-mei

Published
2019
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20. Evaluating Efficacy and Safety of Tacrolimus Treatment in Membranous Nephropathy: Results of a Retrospective Study of 182 Patients

Author

Liang,Shuang, Liang,Yan-Jun, Li,Zhao, Wang,Yong, Guo,Xin-Ru, Zhang,Chao-yang, Zhang,Chun, Wu,Jie, Wang,Xiao-Long, Li,Yi-Sha, Cai,Guang-Yan, Chen,Xiang-Mei, Liang,Shuang, Liang,Yan-Jun, Li,Zhao, Wang,Yong, Guo,Xin-Ru, Zhang,Chao-yang, Zhang,Chun, Wu,Jie, Wang,Xiao-Long, Li,Yi-Sha, Cai,Guang-Yan, and Chen,Xiang-Mei

Abstract

Shuang Liang,1 Yan-Jun Liang,1 Zhao Li,2 Yong Wang,1 Xin-Ru Guo,1 Chao-yang Zhang,1 Chun Zhang,1 Jie Wu,1 Xiao-Long Wang,1 Yi-Sha Li,1 Guang-Yan Cai,1 Xiang-Mei Chen1 1Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, People’s Republic of China; 2Haikou People’s Hospital Affiliated to Xiangya School of Medicine, Haikou, People’s Republic of ChinaCorrespondence: Guang-Yan Cai, Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, People’s Republic of China, Tel +86 13601062936, Fax +86 010-68130297, Email caiguangyan@sina.comPurpose: Tacrolimus is recommended by KDIGO Clinical Practice Guidelines as an initial therapy for the treatment of membranous nephropathy (MN). However, little is known about the factors that influence response and recurrence of the disease after tacrolimus therapy, and there are limited data regarding the duration of tacrolimus treatment. Here, we present a real-world retrospective cohort study of 182 MN patients treated with tacrolimus, aiming to assess the efficacy and safety of tacrolimus in the treatment of MN.Patients and Methods: The clinical data of 182 patients with MN treated with tacrolimus and followed up for at least one year were analyzed retrospectively for the efficacy and safety of tacrolimus.Results: The mean follow-up period was 27.3 (19.3– 41.6) months. A total of 154 patients (84.6%) achieved complete or partial remission, and 28 patients (15.4%) did not. Multivariate Cox regression analysis showed that male and higher baseline

Published
2023

34. Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9+ renal tubular cells

Author

Chen, Jian-Wen, primary, Huang, Meng-Jie, additional, Chen, Xiao-Niao, additional, Wu, Ling-Ling, additional, Li, Qing-Gang, additional, Hong, Quan, additional, Wu, Jie, additional, Li, Fei, additional, Chen, Liang-Mei, additional, Dong, Yu, additional, Cai, Guang-Yan, additional, Bai, Xue-Yuan, additional, Li, Zongjin, additional, and Chen, Xiang-Mei, additional

Published
2022
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42. Relationships among the Dosage of Erythropoiesis-Stimulating Agents, Erythropoietin Resistance Index, and Mortality in Maintenance Hemodialysis Patients

Author

Pan, Sai, primary, Zhao, De-Long, additional, Li, Ping, additional, Sun, Xue-Feng, additional, Zhou, Jian-Hui, additional, Song, Kang-Kang, additional, Wang, Yong, additional, Miao, Li-Ning, additional, Ni, Zhao-Hui, additional, Lin, Hong-Li, additional, Liu, Fu-You, additional, Li, Ying, additional, He, Ya Ni, additional, Wang, Nian-Song, additional, Wang, Cai-Li, additional, Zhang, Ai-Hua, additional, Chen, Meng-Hua, additional, Yang, Xiao-Ping, additional, Deng, Yue-Yi, additional, Shao, Feng-Min, additional, Fu, Shu-Xia, additional, Fang, Jing-Ai, additional, Cai, Guang-Yan, additional, and Chen, Xiang-Mei, additional

Published
2021
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45. Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial

Author

ZHOU, Jian-Hui, NI, Zhao-Hui, MEI, Chang-Lin, YU, Xue-Qing, LIU, Fu-You, MIAO, Li-Ning, LIU, Zhi-Hong, YUAN, Weijie, ZHANG, Ai-Ping, LIN, Hong-Li, CHEN, Meng-Hua, CHEN, Jiang-Hua, ZHANG, Jin-Yuan, HE, Ya-Ni, CHEN, Jian, ZHAO, Jiu-Yang, DING, Xiao-Qiang, LI, Ying, LI, Rong-Shan, XIE, Ru-Juan, LIU, Wen-Hu, XING, Chang-Ying, WANG, Rong, DENG, Yue-Yi, CAO, Xue-Ying, CAI, Guang-Yan, MOU, Shan, MAO, Zhi-Guo, YANG, Xiao, LIU, Hong, SUN, Jing, YU, Yu-Sheng, LIU, Jun, SHI, Shu-Mei, LI, Long-Kai, TIAN, Na, ZHANG, Xiao-Hui, ZHOU, Wei, YANG, Jie, ZHANG, Yong, SUN, Jing-Di, JI, Jun, ZHANG, Tao, YAN, Yan, LIU, Xiao-Gang, WANG, Gang, ZHANG, Li, ZHANG, Hong, LUO, Jian-Hua, and CHEN, Xiang-Mei

Published
2013
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48. Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians

Author

Han,Qiu-Xia, Zhang,Dong, Zhao,Ya-Li, Liu,Liang, Li,Jing, Zhang,Fu, Luan,Fu-Xin, Liu,Dong-Wei, Liu,Zhang-Suo, Cai,Guang-Yan, Chen,Xiang-Mei, and Zhu,Han-Yu

Subjects
Clinical Interventions in Aging
Abstract

Qiu-Xia Han,1–3,* Dong Zhang,1,* Ya-Li Zhao,4 Liang Liu,5 Jing Li,5 Fu Zhang,5 Fu-Xin Luan,5 Dong-Wei Liu,3 Zhang-Suo Liu,3 Guang-Yan Cai,1,2 Xiang-Mei Chen,1,2 Han-Yu Zhu1 1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases，Beijing Key Laboratory of Kidney Diseases, Beijing 100853, People’s Republic of China; 2Medical College, Nankai University, Tianjin 300000, People’s Republic of China; 3Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology of Zhengzhou University, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou 450052, People’s Republic of China; 4Central Laboratory, Hainan Branch of Chinese PLA General Hospital, Sanya 572000, People’s Republic of China; 5Management Department, Hainan Branch of Chinese PLA General Hospital, Sanya 572000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Han-Yu Zhu; Xiang-Mei ChenDepartment of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of ChinaTel +86 10 6693 7763; +86 10 6693 7748Email hanyuzhu301@126.com; xiangmeichen301@126.comPurpose: Hyperuricemia is an important potential pathogenic factor for hypertension, cardiovascular disease and stroke. The current study aimed to investigate the prevalence of hyperuricemia and its relationship to lifestyle characteristics and dietary habits in centenarians and near-centenarians.Patients and methods: In total, 966 centenarians and 788 near-centenarians were included. Community-based surveys were conducted to collect information about lifestyle. Blood examinations were performed using enzymatic assays. T-tests and χ2 tests were used to investigate significant indicators of hyperuricemia, and multivariate logistic regression was used to analyze the related risk factors. A comprehensive analysis of nineteen modifiable factors, including lifestyle characteristics, dietary habits, general characteristics and blood test indexes, was conducted.Results: The prevalence of hyperuricemia was 29.02%. The percentage of men, waist circumference (WC), waist-hip ratio, estimated glomerular filtration rate (eGFR), levels of total protein (TP), alanine aminotransferase, aspartate aminotransferase, triglycerides, high-density lipoprotein cholesterol, serum homocysteine, serum uric acid, serum urea and serum creatinine, passive smoking, alcohol consumption, snoring, preference for fried flavors, and meat, seafood and vegetable consumption were significantly different between the hyperuricemia group and the normouricemia group (p

Published
2019

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