17 results on '"Cagnazzo, E."'
Search Results
2. Contemporary snapshot of tumor regression grade (TRG) distribution in locally advanced rectal cancer: a cross sectional multicentric experience
- Author
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Germani P., Di Candido F., Leonard D., Cuicchi D., Elmore U., Allaix M. E., Barbieri V. P., D'Allens L., Faes S., Milani M., Caputo D., Martinez C., Grosek J., Caracino V., Christou N., Roodbeen S. X., Bracale U., Wildeboer A., Usai A., Benedetti M., Balani A., Piccinni G., Catarci M., Millo P., Bouvy N., Corcione F., Hompes R., Ris F., Basti M., Tomazic A., Targarona E., Coppola A., Pietrabissa A., Hahnloser D., Adamina M., Viola M., Morino M., Rosati R., Poggioli G., Kartheuser A., Spinelli A., de Manzini N., Bellio G., Iacuzzo C., Zucca A., Corleone P., Giudici F., Palmisano S., Carvello M., Remue C., Bachmann R., Lombard N., Pirlet C., Ryckx A., Massaron S., Pugliese L., Coppola R., Ferrari C., Castiglioni S., Ponte E., Concina S., Piveteau A., An Y., Cagnazzo E., Troian M., Germani, Paola, Di Candido, Francesca, Léonard, Daniel, Cuicchi, Dajana, Elmore, Ugo, Allaix, Marco Ettore, Barbieri, Vittoria Pia, D'Allens, Laura, Faes, Seraina, Milani, Marika, Caputo, Damiano, Martinez, Carmen, Grosek, Jan, Caracino, Valerio, Christou, Niki, Roodbeen, Sapho X, Bracale, Umberto, Wildeboer, Aurelia, Usai, Antonella, Benedetti, Michele, Balani, Alessandro, Piccinni, Giuseppe, Catarci, Marco, Millo, Paolo, Bouvy, Nicole, Corcione, Francesco, Hompes, Roel, Ris, Frédéric, Basti, Massimo, Tomazic, Ale, Targarona, Eduardo, Coppola, Alessandro, Pietrabissa, Andrea, Hahnloser, Dieter, Adamina, Michel, Viola, Massimo, Morino, Mario, Rosati, Riccardo, Poggioli, Gilberto, Kartheuser, Alex, Spinelli, Antonino, de Manzini, Nicolò, Palmisano, Silvia, TRG Snapshot Study Group, Bellio, G., Iacuzzo, C., Zucca, A., Corleone, P., Giudici, F., Palmisano, S., Carvello, M., Remue, C., Bachmann, R., Lombard, N., Pirlet, C., Ryckx, A., Massaron, S., Pugliese, L., Coppola, R., Ferrari, C., Castiglioni, S., Ponte, E., Concina, S., Piveteau, A., An, Y., Cagnazzo, E., Troian, M., Surgery, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Germani P., Di Candido F., Leonard D., Cuicchi D., Elmore U., Allaix M.E., Barbieri V.P., D'Allens L., Faes S., Milani M., Caputo D., Martinez C., Grosek J., Caracino V., Christou N., Roodbeen S.X., Bracale U., Wildeboer A., Usai A., Benedetti M., Balani A., Piccinni G., Catarci M., Millo P., Bouvy N., Corcione F., Hompes R., Ris F., Basti M., Tomazic A., Targarona E., Coppola A., Pietrabissa A., Hahnloser D., Adamina M., Viola M., Morino M., Rosati R., Poggioli G., Kartheuser A., Spinelli A., de Manzini N., Bellio G., Iacuzzo C., Zucca A., Corleone P., Giudici F., Palmisano S., Carvello M., Remue C., Bachmann R., Lombard N., Pirlet C., Ryckx A., Massaron S., Pugliese L., Coppola R., Ferrari C., Castiglioni S., Ponte E., Concina S., Piveteau A., An Y., Cagnazzo E., Troian M., UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, and UCL - (SLuc) Service de chirurgie et transplantation abdominale
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medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,THERAPY ,CHEMORADIOTHERAPY ,Neoadjuvant therapy ,Pathologic complete response ,Rectal cancer ,Tumor regression grade ,Chemoradiotherapy ,Cross-Sectional Studies ,Humans ,Neoadjuvant Therapy ,Neoplasm Staging ,Rectal Neoplasms/diagnostic imaging ,Rectal Neoplasms/surgery ,Rectum/pathology ,Treatment Outcome ,EXCISION ,03 medical and health sciences ,0302 clinical medicine ,NEOADJUVANT CHEMORADIATION ,medicine ,PREOPERATIVE RADIOTHERAPY ,Cross-Sectional Studie ,Tumor Regression Grade ,ddc:617 ,medicine.diagnostic_test ,Rectal Neoplasms ,business.industry ,Standard treatment ,Rectum ,Cancer ,Magnetic resonance imaging ,medicine.disease ,Surgery ,Exact test ,030220 oncology & carcinogenesis ,Original Article ,030211 gastroenterology & hepatology ,Radiology ,FOLLOW-UP ,business ,Human ,MRI - Abstract
Pre-operative chemoradiotherapy (CRT) followed by surgical resection is still the standard treatment for locally advanced low rectal cancer. Nowadays new strategies are emerging to treat patients with a complete response to pre-operative treatment, rendering the optimal management still controversial and under debate. The primary aim of this study was to obtain a snapshot of tumor regression grade (TRG) distribution after standard CRT. Second, we aimed to identify a correlation between clinical tumor stage (cT) and TRG, and to define the accuracy of magnetic resonance imaging (MRI) in the restaging setting. Between January 2017 and June 2019, a cross sectional multicentric study was performed in 22 referral centers of colon-rectal surgery including all patients with cT3-4Nx/cTxN1-2 rectal cancer who underwent pre-operative CRT. Shapiro–Wilk test was used for continuous data. Categorical variables were compared with Chi-squared test or Fisher’s exact test, where appropriate. Accuracy of restaging MRI in the identification of pathologic complete response (pCR) was determined evaluating the correspondence with the histopathological examination of surgical specimens.In the present study, 689 patients were enrolled. Complete tumor regression rate was 16.9%. The “watch and wait” strategy was applied in 4.3% of TRG4 patients. A clinical correlation between more advanced tumors and moderate to absent tumor regression was found (p = 0.03). Post-neoadjuvant MRI had low sensibility (55%) and high specificity (83%) with accuracy of 82.8% in identifying TRG4 and pCR.Our data provided a contemporary description of the effects of pre-operative CRT on a large pool of locally advanced low rectal cancer patients treated in different colon-rectal surgical centers.
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- 2021
3. The behaviour of the peripheral natural killer cells in the foetal growth restriction
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Vesce, F., Cagnazzo, E., Giugliano, E., Mossuto, E., and Roberto Marci
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- 2014
4. Pruritic urticarial papules and plaques of pregnancy
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Giugliano, E., primary, Cagnazzo, E., additional, Servello, T., additional, Mossuto, E., additional, Marci, R., additional, and Patella, A., additional
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- 2012
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5. Low dose of Betamethasone throughout the whole course of pregnancy and fetal growth: a clinical study.
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VESCE, F., GIUGLIANO, E., CAGNAZZO, E., MOSSUTO, E., and MARCI, R.
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AIM: To assess the eventual influence of low dose betamethasone throughout pregnancy on fetal growth. PATIENTS AND METHODS: 320 patients -- admitted to the Section of Obstetrics and Gynecology of Ferrara University from January 2005 to December 2010 -- were subdivided in two groups: 160 patients affected by recurrent spontaneous abortion (Group A), treated by low dose of betamethasone (0.5 mg/daily) throughout pregnancy for preventive purposes, 160 patients with physiological pregnancy as control group (Group B). Primary measured outcomes were neonatal biometric parameters such as birth weight, head circumference and neonatal length. Unpaired t-test was used to compare the neonatal biometric parameters. RESULTS: Birth weight, length and circumference head resulted significantly lower in groups treated by GCs. However, excluding bias as pregnancy complicated by diseases, which could affect fetal growth, biometric neonatal parameters were not different between two groups. Furthermore, analyzing the distribution of the value of birth weight we observed that in the group A there were 44 newborns with a weight even higher than fiftieth percentile. CONCLUSIONS: Betamethasone seems not to influence fetal growth. Our analysis demonstrates that fetal growth is influenced by several factors, therefore, homogeneous study population is essential to have convincing results. [ABSTRACT FROM AUTHOR]
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- 2014
6. Low dose of Betamethasone throughout the whole course of pregnancy and fetal growth: A clinical study
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Vesce, F., Giugliano, E., Cagnazzo, E., Mossuto, E., and Roberto Marci
7. Ileocecal valve syndrome and vitamin b12 deficiency after surgery: a multicentric prospective study.
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Germani P, Zucca A, Giudici F, Terranova S, Troian M, Samardzic N, Greco M, Janez J, Gasparini C, Cagnazzo E, Vignali A, Giannone Codiglione F, Armellini A, Fumagalli UR, Rosati R, Piccinni G, Megevand J, Tomazic A, Corcione F, Palmisano S, and de Manzini N
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- Colectomy, Female, Humans, Male, Prospective Studies, Quality of Life, Surveys and Questionnaires, Ileocecal Valve surgery, Vitamin B 12 Deficiency etiology
- Abstract
Patients undergoing colon resection are often concerned about their functional outcomes after surgery. The primary aim of this prospective, multicentric study was to assess the intestinal activity and health-related quality-of-life (HRQL) after ileocecal valve removal. The secondary aim was to evaluate any vitamin B12 deficiency. The study included patients undergoing right colectomy, extended right colectomy and ileocecal resection for either neoplastic or benign disease. Selected items of GIQLI and EORTC QLQ-CR29 questionnaires were used to investigate intestinal activity and HRQL before and after surgery. Blood samples for vitamin B12 level were collected before and during the follow-up period. The empirical rule effect size (ERES) method was used to explain the clinical effect of statistical results. Linear mixed effect (LME) model for longitudinal data was applied to detect the most important parameters affecting the total score. A total of 158 patients were considered. Applying the ERES method, the analysis of both questionnaires showed clinically and statistically significant improvement of HRQL at the end of the follow-up period. Applying the LME model, worsening of HRQL was correlated with female gender and ileum length when using GIQLI questionnaire, and with female gender, open approach, and advanced cancer stage when using the EORTC QLQ-CR29 questionnaire. No significant deficiency in vitamin B12 levels was observed regardless of the length of surgical specimen. In our series, no deterioration of HRQL and no vitamin B12 deficiency were found during the follow-up period. Nevertheless, warning patients about potential changes in bowel habits is mandatory. In our series, no deterioration of HRQL and no vitamin B12 deficiency were found during the follow-up period. Nevertheless, warning patients about potential changes in bowel habits is mandatory.
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- 2021
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8. Correction to: Ileocecal valve syndrome and vitamin b12 deficiency after surgery: a multicentric prospective study.
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Germani P, Zucca A, Giudici F, Terranova S, Troian M, Samardzic N, Greco M, Janez J, Gasparini C, Cagnazzo E, Vignali A, Giannone Codiglione F, Armellini A, Fumagalli UR, Rosati R, Piccinni G, Megevand J, Tomazic A, Corcione F, Palmisano S, and de Manzini N
- Abstract
One of the co-author Eliana Cagnazzo has been incorrectly published. The correct co-author name has been copied below.
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- 2020
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9. Doppler velocimetry of the ovarian artery as a tool to detect LH surge in stimulated cycles.
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Giugliano E, Cagnazzo E, Vesce F, Giugliano B, Caserta D, Moscarini M, Caldarelli C, Stellin G, and Marci R
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- Adult, Female, Humans, Ovary diagnostic imaging, Ovulation Induction, Prospective Studies, Ultrasonography, Doppler, Color, Fertile Period blood, Luteinizing Hormone blood, Ovary blood supply
- Abstract
Our aim was to assess the velocimetric pattern of the ovarian artery as a possible marker of LH surge in stimulated cycles. A total of 130 women undergoing ovarian stimulation for intrauterine insemination were randomized in two groups. Each woman was stimulated with 75 IU of recombinant FSH starting from the third day of the cycle. Velocimetric indices of the dominant ovarian artery were compared between patients with spontaneous LH surge and those needing HCG administration to trigger dominant follicle rupture. The pulsatility index and the ratio between peak systolic flow and lowest diastolic flow were significantly higher in women that had a spontaneous triggering of ovulation. These parameters had a high and very significant positive correlation with the dosage of luteinizing hormone. Threshold values of 2.60 for PI and 7.68 for S/D had a high sensitivity and specificity to predict LH surge. These velocimetric results demonstrated that an increased resistance in the dominant ovarian artery is correlated to LH surge in stimulated cycles. It may represent a sign of relevant clinical utility in timing of intrauterine insemination and/or natural intercourse.
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- 2014
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10. The behaviour of the peripheral natural killer cells in the foetal growth restriction.
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Vesce F, Cagnazzo E, Giugliano E, Mossuto E, and Marci R
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- Adult, Female, Fetal Growth Retardation diagnostic imaging, Humans, Lymphocyte Count, Pregnancy Trimester, Third immunology, Ultrasonography, Fetal Growth Retardation immunology, Killer Cells, Natural immunology, Lymphocyte Subsets immunology, Pregnancy immunology
- Abstract
Aim: To study the behaviour of the peripheral lymphocyte subsets in foetuses affected by growth restriction., Patients and Methods: Thirty consecutive pregnant women with an ultrasound diagnosis of foetal growth restriction were included in this study (group A) while 30 women with a physiologic pregnancy were recruited as control group (group B). The diagnosis was performed during the ultrasound of the third trimester and confirmed at birth. Blood samples were drawn after the ultrasound of the third trimester for all patients. The analyzed populations were: WBC, total lymphocytes, CD2+, CD3+, CD4+, CD5+, CD8+, CD19+, CD56+, HLA-DR+, CD45+, CD3+HLA-DR+, CD4+CD3+, CD3+CD8+, CD2+CD56+, CD19+CD5+, ratio (CD4+CD3+)/(CD3+CD8+)., Results: The percentage and absolute value of the NK cells was higher in the group A [(20.90 vs. 15.09)%, p = 0.0005; (419.55 vs. 341.40) UI/μl, p = 0.0005]. This trend was confirmed by the CD2+CD56+ natural killer (NK) subset [(18.84 vs. 13.42) UI/μl, p = 0.0005]. Instead, the CD4+ percentage value was lower in the group A [(41.15 vs. 44.84)%, p = 0.03] through the CD4+CD3+/CD3+CD8+ ratio was not significantly different., Conclusions: Our findings reinforce the concept of pregnancy as a controlled systemic inflammatory state that if altered can have adverse consequences for the mother and the foetus.
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- 2014
11. Can Doppler study of the ovarian artery predict the fertility outcome of intrauterine insemination?
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Giugliano E, Cagnazzo E, Giugliano B, Vesce F, Caserta D, Moscarini M, and Marci R
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- Adult, Arteries diagnostic imaging, Confidence Intervals, Female, Humans, Infertility, Female diagnostic imaging, Infertility, Female therapy, Multivariate Analysis, Predictive Value of Tests, Pregnancy, Pregnancy Rate, Prospective Studies, ROC Curve, Sensitivity and Specificity, Ultrasonography, Doppler methods, Ultrasonography, Interventional methods, Insemination, Artificial methods, Ovary blood supply, Ovulation Induction methods, Pregnancy Outcome
- Abstract
Background: To test the velocimetric pattern of the ovarian artery as a routine ovarian reserve test., Methods: We enrolled 317 consecutive patients from January 2011 to June 2012. At the second day of the menstrual cycle, a transvaginal ultrasound was performed to evaluate the antral follicle count and ovarian volume, and Doppler of both ovarian arteries was also performed. Controlled ovarian stimulation was performed and the patients were divided in two groups according to the result of the intrauterine insemination: group A (nonpregnant women) and group B (pregnant women)., Results: Ovarian velocimetric pattern was similar between the two groups. Follicle stimulating hormone value had a significant correlation with the ultrasound markers; however, the multiple regression linear analysis showed that the only independent variables were the antral follicle count (t = -2.74, p = 0.008) and the systolic/diastolic ratio (t = 3.95, p = 0.0005). The best parameters in predicting the pregnancy were the mean ovarian volume, total and partial antral follicle count between 7 and 10 mm, and the mean resistance index (area under the curve: 0.744, 0.671, 0.667, 0.573, respectively)., Conclusions: The Doppler study of the ovarian arteries did not add significant information about the ovarian reserve status. Only the mean resistance index had a significant diagnostic accuracy, but its specificity (53%) is too low to consider it a screening test., (© 2014 Wiley Periodicals, Inc.)
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- 2014
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12. The risk factors for failure of labor induction: a cohort study.
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Giugliano E, Cagnazzo E, Milillo V, Moscarini M, Vesce F, Caserta D, and Marci R
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Purpose: To assess how some factors may influence the failure of labor induction., Methods: We conducted a prospective observational study from January 2009 to December 2011 with 248 patients who were admitted to the Obstetrics Unit of Ferrara University for labor induction. We selected only patients with unfavorable characteristics such as nulliparity, maternal and gestational age, and Bishop score and specific obstetric conditions such as mild preeclampsia, isolated oligohydramnios, premature rupture membrane, gestational diabetes, and hypertension for the success of labor induction., Results: The induction was carried out by rapid-release gel dinoprostone. 200 patients (80.6 %) delivered vaginally (Group A), while 48 (19.4 %) underwent a cesarean section (Group B). Maternal age was one independent significant variable (p = 0.01, OR 1.08) determining the risk of cesarean delivery. Patients affected by mild preeclampsia had a three times higher risk for cesarean section. Despite the several unfavorable characteristics of the patients, the cesarean section rate was comparable to that of the normal population., Conclusions: Several factors and clinical conditions historically considered as negative predictors of induction result should be reassessed. The success of labor induction is determined by many maternal and fetal variables, which must all be taken into account to avoid unnecessary cesarean sections.
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- 2014
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13. Vaginal lactoferrin administration before genetic amniocentesis decreases amniotic interleukin-6 levels.
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Vesce F, Giugliano E, Bignardi S, Cagnazzo E, Colamussi C, Marci R, Valente N, Seraceni S, Maritati M, and Contini C
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- Administration, Intravaginal, Adult, Amniotic Fluid metabolism, Anti-Infective Agents administration & dosage, Anti-Inflammatory Agents administration & dosage, Biomarkers metabolism, Drug Administration Schedule, Female, Humans, Lactoferrin administration & dosage, Patient Outcome Assessment, Pregnancy metabolism, Pregnancy Trimester, Second, Amniocentesis, Amniotic Fluid drug effects, Anti-Infective Agents pharmacology, Anti-Inflammatory Agents pharmacology, Interleukin-6 metabolism, Lactoferrin pharmacology, Pregnancy drug effects
- Abstract
Aim: To verify the eventual efficacy of lactoferrin (LF), an iron-binding glycoprotein, to decrease the amniotic concentration of interleukin-6 (IL-6)., Methods: We prospectively enrolled 60 Caucasian patients at the 16th week of their singleton physiological gestation. A vaginal compound containing 300 mg of LF was administered randomly 4 or 12 h prior to amniocentesis, as to obtain 3 groups: A, 20 untreated patients; B, 20 treated 4 h before amniocentesis; C, 20 treated 12 h before amniocentesis., Results: A normal karyotype was registered in all cases. The comparison of the distribution of IL-6 among the 3 groups showed a highly significant difference (p = 0.001). The difference between mean values of group B and both groups C and A was shown to be highly significant (p = 0.006 and p = 0.03, respectively). In contrast, there was no significant difference between mean values of groups A and C., Conclusion: Vaginal LF administration decreases amniotic IL-6 concentration. We therefore suggest that the glycoprotein may exert a protective role against ominous pregnancy complications linked to an increased level of the cytokine, such as abortion secondary to amniocentesis., (© 2014 S. Karger AG, Basel.)
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- 2014
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14. The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain.
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Giugliano E, Cagnazzo E, Soave I, Lo Monte G, Wenger JM, and Marci R
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- Adult, Amides, Anti-Inflammatory Agents, Non-Steroidal chemistry, Chronic Pain etiology, Chronic Pain prevention & control, Contraceptives, Oral, Combined therapeutic use, Drug Combinations, Drug Therapy, Combination, Dysmenorrhea etiology, Dysmenorrhea prevention & control, Endometriosis immunology, Endometriosis physiopathology, Fascia drug effects, Fascia immunology, Female, Female Urogenital Diseases immunology, Female Urogenital Diseases physiopathology, Glucosides chemistry, Humans, Middle Aged, Ovarian Diseases drug therapy, Ovarian Diseases immunology, Ovarian Diseases physiopathology, Pain Measurement, Pelvic Pain etiology, Prospective Studies, Stereoisomerism, Stilbenes chemistry, Young Adult, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Endocannabinoids therapeutic use, Endometriosis drug therapy, Ethanolamines therapeutic use, Female Urogenital Diseases drug therapy, Glucosides therapeutic use, Palmitic Acids therapeutic use, Pelvic Pain prevention & control, Stilbenes therapeutic use
- Abstract
Objective: To test the adjuvant use of the combination of N-palmitoylethanolamine and transpolydatin in the medical treatment of endometriotic pain., Study Design: We enrolled 47 patients admitted to the Outpatient Endometriosis Care Unit of Ferrara University from January 2011 to December 2011. They were divided into two groups according to the endometriosis site (group A: recto-vaginal septum; group B: ovary). One tablet, containing 400 mg of micronized N-palmitoylethanolamine plus 40 mg transpolydatin, was administered twice daily on a full stomach for 90 days. Each patient was requested to grade the severity of dysmenorrhea, chronic pelvic pain, dyspareunia and dyschezia using a 0-10 cm visual analogic scale prior to beginning treatment (T0), after 30 days (T1), 60 days (T2) and 90 days (T3). The continuous and categorical variables were compared, respectively, using Student's t-test and the chi-square test. Analysis of variance for repeated measures was used to verify the reduction of endometriotic pain., Results: The intensity of endometriotic pain decreased significantly for both groups (p<0.0001). The efficacy of drug treatment was significant after 30 days. Pain intensity decreased equally in the two groups except for dysmenorrhea, which was reduced more rapidly in group B., Conclusions: The combination of N-palmitoylethanolamine and transpolydatin reduced pain related to endometriosis irrespective of lesion site. It had a marked effect on chronic pelvic pain determined by deep endometriosis and on dysmenorrhea correlated to ovarian endometriosis., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
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15. The critical pregnant patient: A field of competence not only obstetric.
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Giugliano E, Cagnazzo E, Servello T, and Marci R
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- 2013
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16. Ovarian stimulation and liver dysfunction: Is a clinical relationship possible? A case of hepatic failure after repeated cycles of ovarian stimulation.
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Giugliano E, Cagnazzo E, Pansini G, Vesce F, and Marci R
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Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript tried to fill this gap. We reported a case of a 35-year-old nulliparous woman admitted to our obstetric emergency room for severe pre-eclampsia. She had been subjected to four cycles of controlled ovarian stimulation for intrauterine insemination. At 32 weeks of gestation, she developed severe pre-eclampsia, which led to HELLP syndrome complicated by fatal liver failure. The etiological link between ovarian stimulation and HELLP syndrome is intriguing. Further investigations are needed to understand whether repeated ovarian stimulation may represent a risk factor in pre-eclamptic patients.
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- 2013
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17. Hysterosalpingo-contrast sonography: is possible to quantify the therapeutic effect of a diagnostic test?
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Giugliano E, Cagnazzo E, Bazzan E, Patella A, and Marci R
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Objective: To evaluate the effect of hysterosalpingo-contrast sonography (HyCoSy) on natural conception in the infertile patient., Methods: We conducted a prospective observational study recruiting 180 patients admitted to Infertility Center of Ferrara University from January 2010 to February 2012. The essential inclusion criteria was the couple's desire to perform only diagnostic evaluation on infertility causes and to wait for natural conception before proceeding with further management. Couples were investigated with hormonal profile, semen analysis and HyCoSy. Expected time for spontaneous pregnancy was 180 days from HyCoSy. First datation sonography of pregnancy was used calculating time elapsed from HyCoSy at conception., Results: Forty patients (22.2%) obtained spontaneous pregnancy within 6 months after HyCoSy. The mean of "conception time" was 75 days. The pregnancy rate was significantly higher in the first 30 days (45%) compared to other the months of observation (p<0.0005). Multiple linear regression analysis showed that maternal age and sterility duration proved independent variables in detecting the "conception time" after HyCoSy (t=3.742, p=0.001, t=2.371, p=0.02, respectively)., Conclusion: A possible beneficial effect of HyCoSy is feasible especially in the days following its execution. This temporal correlation supports its therapeutic use.
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- 2012
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