Search

Your search keyword '"Caffa, Irene"' showing total 265 results
Start Over Author "Caffa, Irene"
265 results on '"Caffa, Irene"'

1. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models

Author

Rangan, Priya, Lobo, Fleur, Parrella, Edoardo, Rochette, Nicolas, Morselli, Marco, Stephen, Terri-Leigh, Cremonini, Anna Laura, Tagliafico, Luca, Persia, Angelica, Caffa, Irene, Monacelli, Fiammetta, Odetti, Patrizio, Bonfiglio, Tommaso, Nencioni, Alessio, Pigliautile, Martina, Boccardi, Virginia, Mecocci, Patrizia, Pike, Christian J, Cohen, Pinchas, LaDu, Mary Jo, Pellegrini, Matteo, Xia, Kyle, Tran, Katelynn, Ann, Brandon, Chowdhury, Dolly, and Longo, Valter D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Neurosciences, Brain Disorders, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Nutrition, Acquired Cognitive Impairment, Neurodegenerative, Aging, Stem Cell Research, Dementia, Stem Cell Research - Nonembryonic - Non-Human, Neurological, Alzheimer Disease, Amyloid beta-Peptides, Animals, Cognitive Dysfunction, Disease Models, Animal, Fasting, Mice, Mice, Transgenic, NADPH Oxidases, Neuroinflammatory Diseases, Superoxides, tau Proteins, Alzheimer’s disease, CP: Metabolism, CP: Neuroscience, NADPH oxidase, amyloid beta, fasting, fasting-mimicking diet, hyperphosphorylated tau, microglia, neuroinflammation, protein restriction, superoxide, Medical Physiology, Biological sciences
Abstract

The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles reduce cognitive decline and AD pathology in E4FAD and 3xTg AD mouse models, with effects superior to those caused by protein restriction cycles. In 3xTg mice, long-term FMD cycles reduce hippocampal Aβ load and hyperphosphorylated tau, enhance genesis of neural stem cells, decrease microglia number, and reduce expression of neuroinflammatory genes, including superoxide-generating NADPH oxidase (Nox2). 3xTg mice lacking Nox2 or mice treated with the NADPH oxidase inhibitor apocynin also display improved cognition and reduced microglia activation compared with controls. Clinical data indicate that FMD cycles are feasible and generally safe in a small group of AD patients. These results indicate that FMD cycles delay cognitive decline in AD models in part by reducing neuroinflammation and/or superoxide production in the brain.

Published
2022

4. Dendritic cells direct circadian anti-tumour immune responses

Author

Wang, Chen, Barnoud, Coline, Cenerenti, Mara, Sun, Mengzhu, Caffa, Irene, Kizil, Burak, Bill, Ruben, Liu, Yuanlong, Pick, Robert, Garnier, Laure, Gkountidi, Olga A., Ince, Louise M., Holtkamp, Stephan, Fournier, Nadine, Michielin, Olivier, Speiser, Daniel E., Hugues, Stéphanie, Nencioni, Alessio, Pittet, Mikaël J., Jandus, Camilla, and Scheiermann, Christoph

Published
2023
Full Text
View/download PDF

6. Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells

Author

Agata Sofia Assuncao Carreira, Silvia Ravera, Chiara Zucal, Natthakan Thongon, Caffa Irene, Cecilia Astigiano, Nadia Bertola, Arianna Buongiorno, Michela Roccuzzo, Alessandra Bisio, Barbara Pardini, Alessio Nencioni, Santina Bruzzone, and Alessandro Provenzani

Subjects
FK866, NAMPT, MPC2, Drug resistance, Mitochondrial fitness, Metabolic adaptation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Nicotinamide phosphoribosyltransferase (NAMPT) is a key metabolic enzyme in NAD+ synthesis pathways and is found upregulated in several tumors, depicting NAD(H) lowering agents, like the NAMPT inhibitor FK866, as an appealing approach for anticancer therapy. Like other small molecules, FK866 triggers chemoresistance, observed in several cancer cellular models, which can prevent its clinical application. The molecular mechanisms sustaining the acquired of resistance to FK866 were studied in a model of triple negative breast cancer (MDA-MB-231 parental – PAR), exposed to increasing concentrations of the small molecule (MDA-MB-231 resistant – RES). RES cells are not sensitive to verapamil or cyclosporin A, excluding a potential role of increased efflux pumps activity as a mechanism of resistance. Similarly, the silencing of the enzyme Nicotinamide Riboside Kinase 1 (NMRK1) in RES cells does not increase FK866 toxicity, excluding this pathway as a compensatory mechanism of NAD+ production. Instead, Seahorse metabolic analysis revealed an increased mitochondrial spare respiratory capacity in RES cells. These cells presented a higher mitochondrial mass compared to the FK866-sensitive counterparts, as well as an increased consumption of pyruvate and succinate for energy production. Interestingly, co-treatment of PAR cells with FK866 and the mitochondrial pyruvate carrier (MPC) inhibitors UK5099 or rosiglitazone, as well as with the transient silencing of MPC2 but not of MPC1, induces a FK866-resistant phenotype. Taken together, these results unravel novel mechanisms of cell plasticity to counteract FK866 toxicity, that, besides the previously described LDHA dependency, rely on mitochondrial rewiring at functional and energetic levels.

Published
2023
Full Text
View/download PDF

7. Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer

Author

Bai, Jian-Fei, Majjigapu, Somi Reddy, Sordat, Bernard, Poty, Sophie, Vogel, Pierre, Elías-Rodríguez, Pilar, Moreno-Vargas, Antonio J., Carmona, Ana T., Caffa, Irene, Ghanem, Moustafa, Khalifa, Amr, Monacelli, Fiammetta, Cea, Michele, Robina, Inmaculada, Gajate, Consuelo, Mollinedo, Faustino, Bellotti, Axel, Nahimana, Aimable, Duchosal, Michel, and Nencioni, Alessio

Published
2022
Full Text
View/download PDF

8. Short‐term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence.

Author

Tagliafico, Luca, Da Costa, Renata T., Boccia, Lavinia, Kavehmoghaddam, Sheida, Ramirez, Bryan, Tokarska‐Schlattner, Malgorzata, Scoma, Ernest R., Hambardikar, Vedangi, Bonfiglio, Tommaso, Caffa, Irene, Monacelli, Fiammetta, Schlattner, Uwe, Betley, J. Nicholas, Nencioni, Alessio, and Solesio, Maria E.

Subjects
MITOCHONDRIAL physiology, AMP-activated protein kinases, NEURODEGENERATION, AGING, BIOENERGETICS
Abstract

Neuronal senescence is a major risk factor for the development of many neurodegenerative disorders. The mechanisms that drive neurons to senescence remain largely elusive; however, dysregulated mitochondrial physiology seems to play a pivotal role in this process. Consequently, strategies aimed to preserve mitochondrial function may hold promise in mitigating neuronal senescence. For example, dietary restriction has shown to reduce senescence, via a mechanism that still remains far from being totally understood, but that could be at least partially mediated by mitochondria. Here, we address the role of mitochondrial inorganic polyphosphate (polyP) in the intersection between neuronal senescence and dietary restriction. PolyP is highly present in mammalian mitochondria; and its regulatory role in mammalian bioenergetics has already been described by us and others. Our data demonstrate that depletion of mitochondrial polyP exacerbates neuronal senescence, independently of whether dietary restriction is present. However, dietary restriction in polyP‐depleted cells activates AMPK, and it restores some components of mitochondrial physiology, even if this is not sufficient to revert increased senescence. The effects of dietary restriction on polyP levels and AMPK activation are conserved in differentiated SH‐SY5Y cells and brain tissue of male mice. Our results identify polyP as an important component in mitochondrial physiology at the intersection of dietary restriction and senescence, and they highlight the importance of the organelle in this intersection. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Fasting-mimicking diet and hormone therapy induce breast cancer regression

Author

Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, and Brandhorst, Sebastian

Subjects
Hormone therapy -- Usage -- Methods, Diet therapy -- Methods -- Usage, Breast cancer -- Care and treatment, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Approximately 75% of all breast cancers express the oestrogen and/or progesterone receptors. Endocrine therapy is usually effective in these hormone-receptor-positive tumours, but primary and acquired resistance limits its long-term benefit.sup.1,2. Here we show that in mouse models of hormone-receptor-positive breast cancer, periodic fasting or a fasting-mimicking diet.sup.3-5 enhances the activity of the endocrine therapeutics tamoxifen and fulvestrant by lowering circulating IGF1, insulin and leptin and by inhibiting AKT-mTOR signalling via upregulation of EGR1 and PTEN. When fulvestrant is combined with palbociclib (a cyclin-dependent kinase 4/6 inhibitor), adding periodic cycles of a fasting-mimicking diet promotes long-lasting tumour regression and reverts acquired resistance to drug treatment. Moreover, both fasting and a fasting-mimicking diet prevent tamoxifen-induced endometrial hyperplasia. In patients with hormone-receptor-positive breast cancer receiving oestrogen therapy, cycles of a fasting-mimicking diet cause metabolic changes analogous to those observed in mice, including reduced levels of insulin, leptin and IGF1, with the last two remaining low for extended periods. In mice, these long-lasting effects are associated with long-term anti-cancer activity. These results support further clinical studies of a fasting-mimicking diet as an adjuvant to oestrogen therapy in hormone-receptor-positive breast cancer. In mice, periodic fasting or a fasting-mimicking diet enhances the efficacy of endocrine therapy for breast cancer and delays acquired resistance to it; in patients with breast cancer, a fasting-mimicking diet recreates the metabolic changes observed in mice., Author(s): Irene Caffa [sup.1] , Vanessa Spagnolo [sup.2] [sup.3] , Claudio Vernieri [sup.3] [sup.4] , Francesca Valdemarin [sup.1] [sup.2] , Pamela Becherini [sup.1] [sup.5] , Min Wei [sup.6] , Sebastian [...]

Published
2020
Full Text
View/download PDF

13. SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Author

Becherini, Pamela, Caffa, Irene, Piacente, Francesco, Damonte, Patrizia, Vellone, Valerio G., Passalacqua, Mario, Benzi, Andrea, Bonfiglio, Tommaso, Reverberi, Daniele, Khalifa, Amr, Ghanem, Moustafa, Guijarro, Ana, Tagliafico, Luca, Sucameli, Marzia, Persia, Angelica, Monacelli, Fiammetta, Cea, Michele, Bruzzone, Santina, Ravera, Silvia, and Nencioni, Alessio

Published
2021
Full Text
View/download PDF

15. Effect of Geriatric Comanagement in Older Patients Undergoing Surgery for Gastrointestinal Cancer: A Retrospective, Before-and-After Study

Author

Giannotti, Chiara, Massobrio, Andrea, Carmisciano, Luca, Signori, Alessio, Napolitano, Armando, Pertile, Davide, Soriero, Domenico, Muzyka, Mariya, Tagliafico, Luca, Casabella, Andrea, Cea, Michele, Caffa, Irene, Ballestrero, Alberto, Murialdo, Roberto, Laudisio, Alice, Incalzi, Raffaele Antonelli, Scabini, Stefano, Monacelli, Fiammetta, and Nencioni, Alessio

Published
2022
Full Text
View/download PDF

18. Inhibitors of NAD + Production in Cancer Treatment: State of the Art and Perspectives.

Author

Ghanem, Moustafa S., Caffa, Irene, Monacelli, Fiammetta, and Nencioni, Alessio

Subjects
*NICOTINAMIDE, *DRUG discovery, *CANCER treatment, *ANIMAL models in research, *ANTINEOPLASTIC agents
Abstract

The addiction of tumors to elevated nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of cancer metabolism. Obstructing NAD+ biosynthesis in tumors is a new and promising antineoplastic strategy. Inhibitors developed against nicotinamide phosphoribosyltransferase (NAMPT), the main enzyme in NAD+ production from nicotinamide, elicited robust anticancer activity in preclinical models but not in patients, implying that other NAD+-biosynthetic pathways are also active in tumors and provide sufficient NAD+ amounts despite NAMPT obstruction. Recent studies show that NAD+ biosynthesis through the so-called "Preiss-Handler (PH) pathway", which utilizes nicotinate as a precursor, actively operates in many tumors and accounts for tumor resistance to NAMPT inhibitors. The PH pathway consists of three sequential enzymatic steps that are catalyzed by nicotinate phosphoribosyltransferase (NAPRT), nicotinamide mononucleotide adenylyltransferases (NMNATs), and NAD+ synthetase (NADSYN1). Here, we focus on these enzymes as emerging targets in cancer drug discovery, summarizing their reported inhibitors and describing their current or potential exploitation as anticancer agents. Finally, we also focus on additional NAD+-producing enzymes acting in alternative NAD+-producing routes that could also be relevant in tumors and thus become viable targets for drug discovery. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer

Author

European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Associazione Italiana per la Ricerca sul Cancro, Bai, Jian-Fei [0000-0002-9128-5819], Majjigapu, Somi Reddy [0000-0001-6422-5223], Poty, Sophie [0000-0002-5496-0758], Elías-Rodríguez, Pilar [0000-0002-9117-3905], Moreno-Vargas, Antonio J. [0000-0002-5771-2012], Carmona, Ana T. [0000-0003-1058-7127], Caffa, Irene [0000-0003-1111-9915], Khalifa, Amr [0000-0002-2131-5496], Monacelli, Fiammetta [0000-0003-4303-7252], Cea, Michele [0000-0002-1530-6729], Robina, Inmaculada [0000-0003-1447-8032], Gajate, Consuelo [0000-0003-0604-6459], Mollinedo, Faustino [0000-0002-4939-2434], Nahimana, Aimable [0000-0003-4968-3167], Duchosal, Michel [0000-0003-0543-3449], Nencioni, Alessio [0000-0001-5068-8884], Bai, Jian-Fei, Majjigapu, Somi Reddy, Sordat, Bernard, Poty, Sophie, Vogel, Pierre, Elías-Rodríguez, Pilar, Moreno-Vargas, Antonio J., Carmona, Ana T., Caffa, Irene, Ghanem, Moustafa, Khalifa, Amr, Monacelli, Fiammetta, Cea, Michele, Robina, Inmaculada, Gajate, Consuelo, Mollinedo, Faustino, Bellotti, Axel, Nahimana, Aimable, Duchosal, Michel, Nencioni, Alessio, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Associazione Italiana per la Ricerca sul Cancro, Bai, Jian-Fei [0000-0002-9128-5819], Majjigapu, Somi Reddy [0000-0001-6422-5223], Poty, Sophie [0000-0002-5496-0758], Elías-Rodríguez, Pilar [0000-0002-9117-3905], Moreno-Vargas, Antonio J. [0000-0002-5771-2012], Carmona, Ana T. [0000-0003-1058-7127], Caffa, Irene [0000-0003-1111-9915], Khalifa, Amr [0000-0002-2131-5496], Monacelli, Fiammetta [0000-0003-4303-7252], Cea, Michele [0000-0002-1530-6729], Robina, Inmaculada [0000-0003-1447-8032], Gajate, Consuelo [0000-0003-0604-6459], Mollinedo, Faustino [0000-0002-4939-2434], Nahimana, Aimable [0000-0003-4968-3167], Duchosal, Michel [0000-0003-0543-3449], Nencioni, Alessio [0000-0001-5068-8884], Bai, Jian-Fei, Majjigapu, Somi Reddy, Sordat, Bernard, Poty, Sophie, Vogel, Pierre, Elías-Rodríguez, Pilar, Moreno-Vargas, Antonio J., Carmona, Ana T., Caffa, Irene, Ghanem, Moustafa, Khalifa, Amr, Monacelli, Fiammetta, Cea, Michele, Robina, Inmaculada, Gajate, Consuelo, Mollinedo, Faustino, Bellotti, Axel, Nahimana, Aimable, Duchosal, Michel, and Nencioni, Alessio

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases for which chemotherapy has not been very successful yet. FK866 ((E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide) is a well-known NAMPT (nicotinamide phosphoribosyltransferase) inhibitor with anti-cancer activities, but it failed in phase II clinical trials. We found that FK866 shows anti-proliferative activity in three PDAC cell lines, as well as in Jurkat T-cell leukemia cells. More than 50 FK866 analogues were synthesized that introduce substituents on the phenyl ring of the piperidine benzamide group of FK866 and exchange its buta-1,4-diyl tether for 1-oxyprop-3-yl, (E)-but-2-en-1,4-diyl and 2- and 3-carbon tethers. The pyridin-3-yl moiety of FK866 was exchanged for chlorinated and fluorinated analogues and for pyrazin-2-yl and pyridazin-4-yl groups. Several compounds showed low nanomolar or sub-nanomolar cell growth inhibitory activity. Our best cell anti-proliferative compounds were the 2,4,6-trimethoxybenzamide analogue of FK866 ((E)-N-(4-(1-(2,4,6-trimethoxybenzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide) (9), the 2,6-dimethoxybenzamide (8) and 2-methoxybenzamide (4), which exhibited an IC50 of 0.16 nM, 0.004 nM and 0.08 nM toward PDAC cells, respectively.

Published
2022

22. Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer

Author

Universidad de Sevilla. Departamento de Química orgánica, European Union (UE). H2020, Ministerio de Ciencia e Innovación (MICIN). España, Associazione Italiana per la Ricerca sul Cancro (AIRC), Italian Ministry of Health, Fratta, Simone, Biniecka, Paulina, Moreno Vargas, Antonio José, Carmona Asenjo, Ana Teresa, Nahimana, Aimable, Duchosal, Michel A., Piacente, Francesco, Bruzzone, Santina, Caffa, Irene, Nencioni, Alessio, Robina Ramírez, Inmaculada, Universidad de Sevilla. Departamento de Química orgánica, European Union (UE). H2020, Ministerio de Ciencia e Innovación (MICIN). España, Associazione Italiana per la Ricerca sul Cancro (AIRC), Italian Ministry of Health, Fratta, Simone, Biniecka, Paulina, Moreno Vargas, Antonio José, Carmona Asenjo, Ana Teresa, Nahimana, Aimable, Duchosal, Michel A., Piacente, Francesco, Bruzzone, Santina, Caffa, Irene, Nencioni, Alessio, and Robina Ramírez, Inmaculada

Abstract

Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore NAMPT represents an interesting target for the development of anti-cancer drugs. Several compounds, such as FK866 and CHS828, were identified as potent NAMPT inhibitors with strong anti-cancer activity, although none of them reached the late stages of clinical trials. We present herein the preparation of three libraries of new inhibitors containing (pyridin-3-yl)triazole, (pyridin-3-yl)thiourea and (pyridin-3/4-yl)cyanoguanidine as cap/connecting unit and a furyl group at the tail position of the compound. Antiproliferative activity in vitro was evaluated on a panel of solid and haematological cancer cell lines and most of the synthesized compounds showed nanomolar or sub-nanomolar cytotoxic activity in MiaPaCa-2 (pancreatic cancer), ML2 (acute myeloid leukemia), JRKT (acute lymphobalistic leukemia), NMLW (Burkitt lymphoma), RPMI8226 (multiple myeloma) and NB4 (acute myeloid leukemia), with lower IC50 values than those reported for FK866. Notably, compounds 35a, 39a and 47 showed cytotoxic activity against ML2 with IC50 = 18, 46 and 49 pM, and IC50 towards MiaPaCa-2 of 0.005, 0.455 and 2.81 nM, respectively. Moreover, their role on the NAD+ synthetic pathway was demonstrated by the NAMPT inhibition assay. Finally, the intracellular NAD+ depletion was confirmed in vitro to induced ROS accumulation that cause a time-dependent mitochondrial membrane depolarization, leading to ATP loss and cell death.

Published
2023

23. Data from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair

Author

Piacente, Francesco, primary, Caffa, Irene, primary, Ravera, Silvia, primary, Sociali, Giovanna, primary, Passalacqua, Mario, primary, Vellone, Valerio G., primary, Becherini, Pamela, primary, Reverberi, Daniele, primary, Monacelli, Fiammetta, primary, Ballestrero, Alberto, primary, Odetti, Patrizio, primary, Cagnetta, Antonia, primary, Cea, Michele, primary, Nahimana, Aimable, primary, Duchosal, Michel, primary, Bruzzone, Santina, primary, and Nencioni, Alessio, primary

Published
2023
Full Text
View/download PDF

24. Figure S7 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair

Author

Piacente, Francesco, primary, Caffa, Irene, primary, Ravera, Silvia, primary, Sociali, Giovanna, primary, Passalacqua, Mario, primary, Vellone, Valerio G., primary, Becherini, Pamela, primary, Reverberi, Daniele, primary, Monacelli, Fiammetta, primary, Ballestrero, Alberto, primary, Odetti, Patrizio, primary, Cagnetta, Antonia, primary, Cea, Michele, primary, Nahimana, Aimable, primary, Duchosal, Michel, primary, Bruzzone, Santina, primary, and Nencioni, Alessio, primary

Published
2023
Full Text
View/download PDF

25. Supplemental Figures 1-8 from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells

Author

Cagnetta, Antonia, primary, Caffa, Irene, primary, Acharya, Chirag, primary, Soncini, Debora, primary, Acharya, Prakrati, primary, Adamia, Sophia, primary, Pierri, Ivana, primary, Bergamaschi, Micaela, primary, Garuti, Anna, primary, Fraternali, Giulio, primary, Mastracci, Luca, primary, Provenzani, Alessandro, primary, Zucal, Chiara, primary, Damonte, Gianluca, primary, Salis, Annalisa, primary, Montecucco, Fabrizio, primary, Patrone, Franco, primary, Ballestrero, Alberto, primary, Bruzzone, Santina, primary, Gobbi, Marco, primary, Nencioni, Alessio, primary, and Cea, Michele, primary

Published
2023
Full Text
View/download PDF

26. Supplemental Materials and Methods from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair

Author

Piacente, Francesco, primary, Caffa, Irene, primary, Ravera, Silvia, primary, Sociali, Giovanna, primary, Passalacqua, Mario, primary, Vellone, Valerio G., primary, Becherini, Pamela, primary, Reverberi, Daniele, primary, Monacelli, Fiammetta, primary, Ballestrero, Alberto, primary, Odetti, Patrizio, primary, Cagnetta, Antonia, primary, Cea, Michele, primary, Nahimana, Aimable, primary, Duchosal, Michel, primary, Bruzzone, Santina, primary, and Nencioni, Alessio, primary

Published
2023
Full Text
View/download PDF

27. Data from Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma

Author

Brignole, Chiara, primary, Marimpietri, Danilo, primary, Paolo, Daniela Di, primary, Perri, Patrizia, primary, Morandi, Fabio, primary, Pastorino, Fabio, primary, Zorzoli, Alessia, primary, Pagnan, Gabriella, primary, Loi, Monica, primary, Caffa, Irene, primary, Erminio, Giovanni, primary, Haupt, Riccardo, primary, Gambini, Claudio, primary, Pistoia, Vito, primary, and Ponzoni, Mirco, primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure 1 from Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma

Author

Brignole, Chiara, primary, Marimpietri, Danilo, primary, Paolo, Daniela Di, primary, Perri, Patrizia, primary, Morandi, Fabio, primary, Pastorino, Fabio, primary, Zorzoli, Alessia, primary, Pagnan, Gabriella, primary, Loi, Monica, primary, Caffa, Irene, primary, Erminio, Giovanni, primary, Haupt, Riccardo, primary, Gambini, Claudio, primary, Pistoia, Vito, primary, and Ponzoni, Mirco, primary

Published
2023
Full Text
View/download PDF

29. Supplementary Methods from Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma

Author

Brignole, Chiara, primary, Marimpietri, Danilo, primary, Paolo, Daniela Di, primary, Perri, Patrizia, primary, Morandi, Fabio, primary, Pastorino, Fabio, primary, Zorzoli, Alessia, primary, Pagnan, Gabriella, primary, Loi, Monica, primary, Caffa, Irene, primary, Erminio, Giovanni, primary, Haupt, Riccardo, primary, Gambini, Claudio, primary, Pistoia, Vito, primary, and Ponzoni, Mirco, primary

Published
2023
Full Text
View/download PDF

31. Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression

Author

Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G., Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G., Provenzani, Alessandro, Longo, Valter D., and Nencioni, Alessio

Published
2020
Full Text
View/download PDF

32. Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity

Author

Soncini, Debora, Caffa, Irene, Zoppoli, Gabriele, Cea, Michele, Cagnetta, Antonia, Passalacqua, Mario, Mastracci, Luca, Boero, Silvia, Montecucco, Fabrizio, Sociali, Giovanna, Lasigliè, Denise, Damonte, Patrizia, Grozio, Alessia, Mannino, Elena, Poggi, Alessandro, D'Agostino, Vito G., Monacelli, Fiammetta, Provenzani, Alessandro, Odetti, Patrizio, Ballestrero, Alberto, Bruzzone, Santina, and Nencioni, Alessio

Published
2014
Full Text
View/download PDF

33. Dendritic cells direct circadian anti-tumour immune responses

Author

Wang, Chen, primary, Barnoud, Coline, additional, Cenerenti, Mara, additional, Sun, Mengzhu, additional, Caffa, Irene, additional, Kizil, Burak, additional, Bill, Ruben, additional, Liu, Yuanlong, additional, Pick, Robert, additional, Garnier, Laure, additional, Gkountidi, Olga A., additional, Ince, Louise M., additional, Holtkamp, Stephan, additional, Fournier, Nadine, additional, Michielin, Olivier, additional, Speiser, Daniel E., additional, Hugues, Stéphanie, additional, Nencioni, Alessio, additional, Pittet, Mikaël J., additional, Jandus, Camilla, additional, and Scheiermann, Christoph, additional

Published
2022
Full Text
View/download PDF

36. The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+ Responses

Author

Bauer, Inga, Grozio, Alessia, Lasigliè, Denise, Basile, Giovanna, Sturla, Laura, Magnone, Mirko, Sociali, Giovanna, Soncini, Debora, Caffa, Irene, Poggi, Alessandro, Zoppoli, Gabriele, Cea, Michele, Feldmann, Georg, Mostoslavsky, Raul, Ballestrero, Alberto, Patrone, Franco, Bruzzone, Santina, and Nencioni, Alessio

Published
2012
Full Text
View/download PDF

38. Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Author

Franco, Jorge, primary, Piacente, Francesco, additional, Walter, Melanie, additional, Fratta, Simone, additional, Ghanem, Moustafa, additional, Benzi, Andrea, additional, Caffa, Irene, additional, Kurkin, Alexander V., additional, Altieri, Andrea, additional, Herr, Patrick, additional, Martínez-Bailén, Macarena, additional, Robina, Inmaculada, additional, Bruzzone, Santina, additional, Nencioni, Alessio, additional, and Del Rio, Alberto, additional

Published
2022
Full Text
View/download PDF

39. Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Author

Ghanem, Moustafa S., primary, Caffa, Irene, additional, Del Rio, Alberto, additional, Franco, Jorge, additional, Parenti, Marco Daniele, additional, Monacelli, Fiammetta, additional, Cea, Michele, additional, Khalifa, Amr, additional, Nahimana, Aimable, additional, Duchosal, Michel A., additional, Ravera, Silvia, additional, Bertola, Nadia, additional, Bruzzone, Santina, additional, Nencioni, Alessio, additional, and Piacente, Francesco, additional

Published
2022
Full Text
View/download PDF

43. Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma

Author

Loi, Monica, Marchiò, Serena, Becherini, Pamela, Di Paolo, Daniela, Soster, Marco, Curnis, Flavio, Brignole, Chiara, Pagnan, Gabriella, Perri, Patrizia, Caffa, Irene, Longhi, Renato, Nico, Beatrice, Bussolino, Federico, Gambini, Claudio, Ribatti, Domenico, Cilli, Michele, Arap, Wadih, Pasqualini, Renata, Allen, Theresa M., Corti, Angelo, Ponzoni, Mirco, and Pastorino, Fabio

Published
2010
Full Text
View/download PDF

44. Chapter 12 Liposome-Mediated Therapy of Neuroblastoma

Author

Di Paolo, Daniela, Loi, Monica, Pastorino, Fabio, Brignole, Chiara, Marimpietri, Danilo, Becherini, Pamela, Caffa, Irene, Zorzoli, Alessia, Longhi, Renato, Gagliani, Cristina, Tacchetti, Carlo, Corti, Angelo, Allen, Theresa M., Ponzoni, Mirco, and Pagnan, Gabriella

Published
2009
Full Text
View/download PDF

45. Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment

Author

Valdemarin, Francesca, primary, Caffa, Irene, additional, Persia, Angelica, additional, Cremonini, Anna Laura, additional, Ferrando, Lorenzo, additional, Tagliafico, Luca, additional, Tagliafico, Alberto, additional, Guijarro, Ana, additional, Carbone, Federico, additional, Ministrini, Stefano, additional, Bertolotto, Maria, additional, Becherini, Pamela, additional, Bonfiglio, Tommaso, additional, Giannotti, Chiara, additional, Khalifa, Amr, additional, Ghanem, Moustafa, additional, Cea, Michele, additional, Sucameli, Marzia, additional, Murialdo, Roberto, additional, Barbero, Valentina, additional, Gradaschi, Raffaella, additional, Bruzzone, Francesca, additional, Borgarelli, Consuelo, additional, Lambertini, Matteo, additional, Vernieri, Claudio, additional, Zoppoli, Gabriele, additional, Longo, Valter D., additional, Montecucco, Fabrizio, additional, Sukkar, Samir G., additional, and Nencioni, Alessio, additional

Published
2021
Full Text
View/download PDF

48. Abstract CT075: Fasting-mimicking diet and hormone therapy modulates metabolic factors to promote breast cancer regression and reduce side effects

Author

Caffa, Irene, primary, Spagnolo, Vanessa, additional, Becherini, Pamela, additional, Valdemarin, Francesca, additional, Vernieri, Claudio, additional, Wei, Min, additional, Brandhorst, Sebastian, additional, Zucal, Chiara, additional, Driehuis, Else, additional, Ferrando, Lorenzo, additional, Mastracci, Luca, additional, Cilli, Michele, additional, Piacente, Francesco, additional, Cremonini, Anna Laura, additional, Passalacqua, Mario, additional, Vellone, Valerio, additional, Zoppoli, Gabriele, additional, Cea, Michele, additional, Salvadori, Giulia, additional, Cortellino, Salvatore, additional, Clevers, Hans, additional, De Braud, Filippo, additional, Provenzani, Alessandro, additional, Longo, Valter D., additional, and Nencioni, Alessio, additional

Published
2020
Full Text
View/download PDF

49. Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression

Author

CMM Sectie Molecular Cancer Research, Child Health, Regenerative Medicine and Stem Cells, Cancer, Hubrecht Institute with UMC, Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G, Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G, Provenzani, Alessandro, Longo, Valter D, Nencioni, Alessio, CMM Sectie Molecular Cancer Research, Child Health, Regenerative Medicine and Stem Cells, Cancer, Hubrecht Institute with UMC, Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G, Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G, Provenzani, Alessandro, Longo, Valter D, and Nencioni, Alessio

Published
2020

50. Fasting-mimicking diet and hormone therapy induce breast cancer regression

Author

CMM Sectie Molecular Cancer Research, Child Health, Regenerative Medicine and Stem Cells, Cancer, Hubrecht Institute with UMC, Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G, Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G, Provenzani, Alessandro, Longo, Valter D, Nencioni, Alessio, CMM Sectie Molecular Cancer Research, Child Health, Regenerative Medicine and Stem Cells, Cancer, Hubrecht Institute with UMC, Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G, Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G, Provenzani, Alessandro, Longo, Valter D, and Nencioni, Alessio

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results