375 results on '"Caenepeel P"'
Search Results
2. DOMINO trial analysis: evaluation of the diet effects on symptoms in IBS subtypes
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Claudia Di Rosa, Karen Van den Houte, Annamaria Altomare, Michele Pier Luca Guarino, Linde Besard, Joris Arts, Philip Caenepeel, Hubert Piessevaux, Alain Vandenberghe, Cristophe Matthys, Jessica R. Biesiekierski, Luc Capiau, Steven Ceulemans, Olivier Gernay, Lydia Jones, Sophie Maes, Christian Peetermans, Willem Raat, Jeroen Stubbe, Rudy Van Boxstael, Olivia Vandeput, Sophie Van Steenbergen, Lukas Van Oudenhove, Tim Vanuytsel, Mike Jones, Jan Tack, and Florencia Carbone
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain related to defecation and/or associated to a change in bowel habits. According to the stool type, four different IBS subtypes can be recognized, constipation predominant (IBS-C), diarrhea predominant (IBS-D), mixed (IBS-M), and undefined (IBS-U). Patients report that their IBS symptoms are exacerbated by food. Thus, it is important to find a nutritional approach that could be effective in reducing IBS symptoms. Objective: The present work is a post hoc analysis of the previously published DOMINO trial. It aimed to evaluate the effects of a self-instructed FODMAP-lowering diet smartphone application on symptoms and psychosocial aspects in primary care IBS stratifying the results for each IBS subtypes. Design: Post hoc analysis. Methods: Two hundred twenty-two primary care IBS patients followed a FODMAP-lowering diet for 8 weeks with the support of a smartphone application. Two follow-up visits were scheduled after 16 and 24 weeks. IBS–Symptoms Severity Score (IBS-SSS), quality of life (QoL), and adherence and dietary satisfaction were evaluated. Results: After 8 weeks, IBS-SSS improved in all IBS subtypes ( p
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- 2024
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3. Glider Representation Rings with a view on distinguishing groups
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Caenepeel, Frederik and Janssens, Geoffrey
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Mathematics - Representation Theory - Abstract
Let $G$ be a finite group. In the first part of the paper we develop further the foundations of the youngly introduced glider representation theory. Glider representations encompass filtered modules over filtered rings and as such carry much information of $G$. Therefore the main focus is on the glider representation ring $R_d(\widetilde{G})$, which is shown to be realisable as a concrete subring of the split Grothendieck ring of the monoidal category $\text{glid}_d(G)$ of (Noetherian) glider $\mathbb{C}$-representations of (length $d$) of $G$. In the second part we investigate a Wedderburn-Malcev type decomposition of the (infinite-dimensional) $\mathbb{Q}$-algebra $\mathbb{Q}(\widetilde{G}) := \mathbb{Q} \otimes_{\mathbb{Z}}R_1(\widetilde{G})$. The main theorem obtains a $\mathbb{Q}[G^{ab}]$-module decomposition of $\mathbb{Q}(\widetilde{G})$ relating it in a precise way to $\mathbb{C}$-representation theory of subnormal subgroups in $G$. Under certain vanishing assumptions, which are proven to hold for nilpotent groups (of class $2$), the second main theorem completely describes a $\mathbb{Q}[G^{ab}]$-algebra decomposition. We end with pointing out applications on distinguishing isocategorical groups., Comment: v2: the paper has been strongly rewritten. Among others, the main decomposition results have been improved but also new results have been added. In particular section 3 and 6 are fully new. 41 pages
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- 2019
4. Glider Brauer-Severi varietes of central simple algebras
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Caenepeel, Frederik and Van Oystaeyen, Freddy
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Mathematics - Rings and Algebras ,16W60, 16W70 - Abstract
The glider Brauer-Severy variety GBS(A) of a central simple algebra A over a field K is introduced as the set of all irreducible left glider ideals in A for some filtration FA. For fields we deduce that GBS(K) equals R(K) x Z, the product of the Riemann surface of K and the ring of integers Z. For a csa A over K it turns out that GBS(A) = BS(A) x GBS(K), where BS(A) denotes the classical Brauer-Severi variety of A., Comment: 24 pages, submitted for publication
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- 2019
5. On the cohomology of comodules over smash coproducts
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Caenepeel, S. and Guédénon, T.
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Mathematics - Rings and Algebras ,16S40, 16W30 - Abstract
We consider the category of comodules over a smash coproduct coalgebra $C\smashco H$. We show that there is a Grothendieck spectral sequence connecting the derived functors of the Hom functors coming from $C\smashco H$-colinear, $H$-colinear and rational $C$-colinear morphisms. We give several applications and connect our results to existing spectral sequences in the literature., Comment: 15 pages
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- 2018
6. Generalized characters for glider representations of groups
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Caenepeel, Frederik and Van Oystaeyen, Fred
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Mathematics - Group Theory - Abstract
Glider representations can be defined for a finite algebra filtration FKG determined by a chain of subgroups 1 < G_1 < ... < G_d = G. In this paper we develop the generalized character theory for such glider representations. We give the generalization of Artin's theorem and define a generalized inproduct. For finite abelian groups G with chain 1 < G, we explicitly calculate the generalized character ring and compute its semisimple quotient. The papers ends with a discussion of the quaternion group as a first non-abelian example., Comment: 21 pages, accepted for publication in Algebras and Representation Theory
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- 2018
7. Descent and Galois theory for Hopf categories
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Caenepeel, S. and Fieremans, T.
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Mathematics - Rings and Algebras ,Mathematics - Category Theory ,16T05 - Abstract
Descent theory for linear categories is developed. Given a linear category as an extension of a diagonal category, we introduce descent data, and the category of descent data is isomorphic to the category of representations of the diagonal category, if some flatness assumptions are satisfied. Then Hopf-Galois descent theory for linear Hopf categories, the Hopf algebra version of a linear category, is developed. This leads to the notion of Hopf-Galois category extension. We have a dual theory, where actions by dual linear Hopf categories on linear categories are considered. Hopf-Galois category extensions over groupoid algebras correspond to strongly graded linear categories., Comment: 38 pages
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- 2017
8. Glider representations of chains of semisimple Lie algebras
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Caenepeel, Frederik
- Subjects
Mathematics - Representation Theory ,17B10, 17B22 - Abstract
We start the study of glider representations in the setting of semisimple Lie algebras. A glider representation is defined for some positively filtered ring $FR$ and here we consider the right bounded algebra filtration $FU(\mathfrak{g})$ on the universal enveloping algebra $U(\mathfrak{g})$ of some semisimple Lie algebra $\mathfrak{g}$ given by a fixed chain of semisimple sub Lie algebras $\mathfrak{g}_1 \subset \mathfrak{g}_2 \subset \ldots \subset \mathfrak{g}_n = \mathfrak{g}$. Inspired by the classical representation theory, we introduce so-called Verma glider representations. Their existence is related to the relations between the root systems of the appearing Lie algebras $\mathfrak{g}_i$. In particular, we consider chains of simple Lie algebras of the same type $A,B,C$ and $D$., Comment: 24 pages
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- 2017
9. Frobenius and separable functors for the category of entwined modules over cowreaths, I: General theory
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Bulacu, D., Caenepeel, S., and Torrecillas, B.
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Mathematics - Category Theory ,16T05, 18D10, 16T15, 16S40 - Abstract
Entwined modules over cowreaths in a monoidal category are introduced. They can be identified to coalgebras in an appropriate monoidal category. It is investigated when such coalgebras are Frobenius (resp. separable), and when the forgetful functor from entwined modules to representations of the underlying algebra is Frobenius (resp. separable). These properties are equivalent when the unit object of the category is a $\otimes$-generator., Comment: 34 pages
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- 2016
10. Glider representations of group algebra filtrations of nilpotent groups
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Caenepeel, Frederik and Van Oystaeyen, Fred
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Mathematics - Representation Theory - Abstract
We continue the study of glider representations of finite groups $G$ with given structure chain of subgroups $e \subset G_1 \subset \ldots \subset G_d = G$. We give a characterization of irreducible gliders of essential length $e \leq d$ which in the case of $p$-groups allows to prove some results about classical representation theory. The paper also contains an introduction to generalized character theory for glider representations and an extension of the decomposition groups in the Clifford theory. Furthermore, we study irreducible glider representations for finite nilpotent groups., Comment: 18 pages Erratum fixed: the result in Corollary 3.17 is only valid for H a maximal normal subgroup
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- 2016
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11. Microbiota, not host origin drives ex vivo intestinal epithelial responses
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Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Séverine Vermeire, João Sabino, Catherine Verfaillie, and Marc Ferrante
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Ulcerative colitis ,epithelial cells ,microbiota ,dysbiosis ,organoids ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Microbial dysbiosis is an established finding in patients with inflammatory bowel disease (IBD), but host-microbial interactions are poorly understood. We aimed to unravel the effect of microbiota exposure on intestinal epithelial cells. Confluent Transwell® organoid monolayers of eight UC patients and eight non-IBD controls were co-cultured for six hours with microbiota (3x108 cells) of UC patients or a healthy volunteer (HV), in the presence or absence of an inflammatory cytokine mix. Transepithelial electrical resistance (TEER), fluorescein isothiocyanate (FITC) dextran measurements, and RNA sequencing were performed on epithelial cells, and 16S rRNA sequencing on microbiota samples before and after co-culture. Transcriptomic response following microbiota exposure was not different between epithelial cells from UC patients or non-IBD controls. Following UC microbiota exposure, but not HV microbiota, a strong decrease in epithelial barrier integrity was observed in both UC and HV epithelial cells by TEER and FITC dextran measurements. Exposure of inflamed epithelium to UC microbiota induced transcriptomic stress pathways including activation of EGR1, MAPK and JAK/STAT signaling, as well as AP-1 family and FOSL transcripts. Stress responses after HV microbiota stimulation were milder. We conclude that not the epithelial cell origin (UC versus non-IBD) but the microbial donor drives transcriptomic responses, as exposure to UC microbiota was sufficient to induce stress responses in all epithelial cells. Further research on therapies to restore the microbial balance, to remove the constant trigger of dysbiosis, is required.
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- 2022
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12. Position statement on how can we can implement the Greendeal in our gastrointestinal and gastrointestinal endoscopy department in Belgium
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Aerts, M, primary, Reynaert, H, additional, Roelandt, P, additional, Caenepeel, P, additional, Dewint, P, additional, Lemmers, A, additional, and Colle, I, additional
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- 2024
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13. Clifford theory for glider representations
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Caenepeel, Frederik and Van Oystaeyen, Fred
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Mathematics - Representation Theory - Abstract
Classical Clifford theory studies the decomposition of simple $G$-modules into simple $H$-modules for some normal subgroup $H \triangleleft G$. In this paper we deal with chains of normal subgroups $1 \triangleleft G_1 \triangleleft \cdots \triangleleft G_d =G$, which allow to consider fragments and in particular glider representations. These are given by a descending chain of vector spaces over some field $K$ and relate different representations of the groups appearing in the chain. Picking some normal subgroup $H \triangleleft G$ one obtains a normal subchain and one can construct an induced fragment structure. Moreover, a notion of irreducibility of fragments is introduced, which completes the list of ingredients to perform a Clifford theory., Comment: 15 pages. There was an erratum at the beginning of section 4. This could be omitted without further consequences to the results in the paper. To appear in Algebras and Representation Theory
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- 2016
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14. Localization and sheaves of glider representations
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Caenepeel, Frederik and Van Oystaeyen, Fred
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Mathematics - Rings and Algebras - Abstract
The notion of a glider representation of a chain of normal subgroups of a group is defined by a new structure, i.e. a fragment for a suitable filtration on the group ring. This is a special case of general glider representations defined for a positively filtered ring $R$ with filtration $FR$ and subring $S = F_0R$. Nice examples appear for chains of groups, chains of Lie algebras, rings of differential operators on some variety or $V$-gliders for $W$ for algebraic varieties $V$ and $W$. This paper aims to develop a scheme theory for glider representations via the localizations of filtered modules. With an eye to noncommutative geometry we allow schemes over noncommutative rings with particular attention to so-called almost commutative rings. We consider particular cases of $\mathrm{Proj}~ R$ (e.g. for some P.I. ring $R$) in terms of prime ideals, $R$-tors in terms of torsion theories and $\underline{\mathcal{W}}(R)$ in terms of a noncommutative Grothendieck topology based on words of Ore set localizations., Comment: 32 pages
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- 2016
15. MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor
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Caenepeel, Sean, Cooke, Keegan, Wadsworth, Sarah, Huang, Guo, Robert, Lidia, Moreno, Blanca Homet, Parisi, Giulia, Cajulis, Elaina, Kendall, Richard, Beltran, Pedro, Ribas, Antoni, Coxon, Angela, and Hughes, Paul E
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Cancer ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Adaptor Proteins ,Signal Transducing ,Animals ,Antineoplastic Agents ,Apoptosis ,Benzamides ,Cell Line ,Tumor ,Dipeptides ,Diphenylamine ,Drug Resistance ,Neoplasm ,Female ,Hepatocyte Growth Factor ,Humans ,Indoles ,MAP Kinase Signaling System ,Melanoma ,Mice ,Mice ,Nude ,Protein Kinase Inhibitors ,Proto-Oncogene Proteins B-raf ,Proto-Oncogene Proteins c-met ,Pyridones ,Sulfonamides ,Triazoles ,Vemurafenib ,Xenograft Model Antitumor Assays ,BRAF ,HGF ,MET ,melanoma ,resistance ,Oncology and Carcinogenesis - Abstract
Therapeutic resistance is a major obstacle to achieving durable clinical responses with targeted therapies, highlighting a need to elucidate the underlying mechanisms responsible for resistance and identify strategies to overcome this challenge. An emerging body of data implicates the tyrosine kinase MET in mediating resistance to BRAF inhibitors in BRAFV600E mutant melanoma. In this study we observed a dominant role for the HGF/MET axis in mediating resistance to BRAF and MEK inhibitors in models of BRAFV600E and NRAS mutant melanoma. In addition, we showed that MAPK pathway inhibition induced rapid increases in MET and GAB1 levels, providing novel mechanistic insight into how BRAFV600E mutant melanoma is primed for HGF-mediated rescue. We also determined that tumor-derived HGF, not systemic HGF, may be required to convey resistance to BRAF inhibition in vivo and that resistance could be reversed following treatment with AMG 337, a selective MET inhibitor. In summary, these findings support the clinical evaluation of MET-directed targeted therapy to circumvent resistance to BRAF and MEK inhibitors in BRAFV600E mutant melanoma. In addition, the induction of MET following treatment with BRAF and MEK inhibitors has the potential to serve as a predictive biomarker for identifying patients best suited for MET inhibitor combination therapy.
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- 2017
16. Hopf Categories
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Batista, E., Caenepeel, S., and Vercruysse, J.
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Mathematics - Quantum Algebra ,16T05 - Abstract
We introduce Hopf categories enriched over braided monoidal categories. The notion is linked to several recently developed notions in Hopf algebra theory, such as Hopf group (co)algebras, weak Hopf algebras and duoidal categories. We generalize the fundamental theorem for Hopf modules and some of its applications to Hopf categories., Comment: 47 pages; final version to appear in Algebras and Representation Theory
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- 2015
17. Efficacy and Findings of a Blinded Randomized Reintroduction Phase for the Low FODMAP Diet in Irritable Bowel Syndrome.
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Van den Houte, Karen, Colomier, Esther, Routhiaux, Karen, Mariën, Zoë, Schol, Jolien, Van den Bergh, Jasmien, Vanderstappen, Julie, Pauwels, Nelle, Joos, Annick, Arts, Joris, Caenepeel, Philip, De Clerck, Frederik, Matthys, Christophe, Meulemans, Ann, Jones, Mike, Vanuytsel, Tim, Carbone, Florencia, and Tack, Jan
- Abstract
The efficacy of a low fermentable oligo-, di-, monosaccharides and polyols (FODMAP) diet in irritable bowel syndrome (IBS) is well established. After the elimination period, a reintroduction phase aims to identify triggers. We studied the impact of a blinded reintroduction using FODMAP powders to objectively identify triggers and evaluated the effect on symptoms, quality of life, and psychosocial comorbidities. Responders to a 6-week low FODMAP diet, defined by a drop in IBS symptom severity score (IBS-SSS) compared with baseline, entered a 9-week blinded randomized reintroduction phase with 6 FODMAP powders (fructans, fructose, galacto-oligosaccharides, lactose, mannitol, sorbitol) or control (glucose). A rise in IBS-SSS (≥50 points) defined a FODMAP trigger. Patients completed daily symptom diaries and questionnaires for quality of life and psychosocial comorbidities. In 117 recruited patients with IBS, IBS-SSS improved significantly after the elimination period compared with baseline (150 ± 116 vs 301 ± 97, P <.0001, 80% responders). Symptom recurrence was triggered in 85% of the FODMAP powders, by an average of 2.5 ± 2 FODMAPs/patient. The most prevalent triggers were fructans (56%) and mannitol (54%), followed by galacto-oligosaccharides, lactose, fructose, sorbitol, and glucose (respectively 35%, 28%, 27%, 23%, and 26%) with a significant increase in abdominal pain at day 1 for sorbitol/mannitol, day 2 for fructans/galacto-oligosaccharides, and day 3 for lactose. We confirmed the significant benefit of the low FODMAP diet in tertiary-care IBS. A blinded reintroduction revealed a personalized pattern of symptom recurrence, with fructans and mannitol as the most prevalent, and allows the most objective identification of individual FODMAP triggers. Ethical commission University hospital of Leuven reference number: s63629; Clinicaltrials.gov number: NCT04373304. We studied the impact of a blinded reintroduction using fermentable oligo-, di-, monosaccharides and polyols (FODMAP) powders to identify triggering FODMAPs. It allows the most objective identification of individual triggers and would optimize clinical practice. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Integrated analysis of microbe-host interactions in Crohn’s disease reveals potential mechanisms of microbial proteins on host gene expression
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Padhmanand Sudhakar, Tahila Andrighetti, Sare Verstockt, Clara Caenepeel, Marc Ferrante, João Sabino, Bram Verstockt, and Severine Vermeire
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Gastroenterology ,Molecular genetics ,Microbiome ,Science - Abstract
Summary: Inflammatory responses of the intestinal epithelial barrier in patients with Crohn’s disease (CD), a chronic inflammatory bowel disease (IBD), are associated with gut microbial alterations. At a community level, there is scarce mechanistic evidence on the effects of gut microbial alterations on host mucosal barrier responses. We used a computational microbe-host interaction prediction framework based on network diffusion and systems biology to integrate publicly available paired gut microbial and intestinal gene expression datasets. The ileal signaling network potentially modulated by the microbiota was enriched with immune-related pathways such as those associated with IL-4, IL-2, IL-13, NFkB, and toll-like receptors. We identified bacterial proteins eliciting post-translational modifications on host receptors, resulting in the de-repression of pro-inflammatory cytokines via critical hub proteins such as NFkB. The signaling networks were over-represented with CD associated genes and CD drug targets. Using datasets generated from our validation cohorts, we confirmed some of the results.
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- 2022
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19. Frobenius and Separable Functors for the Category of Entwined Modules over Cowreaths, I: General Theory
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Bulacu, D., Caenepeel, S., and Torrecillas, B.
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- 2020
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20. Generalized Characters for Glider Representations of Groups
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Caenepeel, Frederik and Van Oystaeyen, Fred
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- 2020
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21. Monoidal ring and coring structures obtained from wreaths and cowreaths
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Bulacu, D. and Caenepeel, S.
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Mathematics - Rings and Algebras ,Mathematics - Quantum Algebra ,16T05, 18D05, 18D10 - Abstract
Let $A$ be an algebra in a monoidal category $\Cc$, and let $X$ be an object in $\Cc$. We study $A$-(co)ring structures on the left $A$-module $A\ot X$. These correspond to (co)algebra structures in $EM(\Cc)(A)$, the Eilenberg-Moore category associated to $\Cc$ and $A$. The ring structures are in bijective correspondence to wreaths in $\Cc$, and their category of representations is the category of representations over the induced wreath product. The coring structures are in bijective correspondence to cowreaths in $\Cc$, and their category of corepresentations is the category of generalized entwined modules. We present several examples coming from (co)actions of Hopf algebras and their generalizations. Various notions of smash products that have appeared in the literature appear as special cases of our construction., Comment: 34 pages; to appear in Algebras Represent. Theory
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- 2013
22. The uniqueness of braidings on the monoidal category of non-commutative descent data
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Agore, A. L., Caenepeel, S., and Militaru, G.
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Mathematics - Quantum Algebra ,Mathematics - Category Theory - Abstract
Let $A$ be an algebra over a commutative ring $k$. It is known that the categories of non-commutative descent data, of comodules over the Sweedler canonical coring, of right $A$-modules with a flat connection are isomorphic as braided monoidal categories to the center of the category of $A$-bimodules. We prove that the braiding on these categories is unique if there exists a $k$-linear unitary map $E : A \to Z(A)$. This condition is satisfied if $k$ is a field or $A$ is a commutative or a separable algebra., Comment: 9 pages, submitted
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- 2012
23. Stable equivalence of Morita type and Frobenius extensions
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Beattie, M., Caenepeel, S., and Raianu, S.
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Mathematics - Rings and Algebras ,16T15, 16D90 - Abstract
A.S. Dugas and R. Mart\'{i}nez-Villa proved in \cite[Corollary 5.1]{dm} that if there exists a stable equivalence of Morita type between the $k$-algebras $\Lambda$ and $\Gamma$, then it is possible to replace $\Lambda$ by a Morita equivalent $k$-algebra $\Delta$ such that $\Gamma$ is a subring of $\Delta$ and the induction and restriction functors induce inverse stable equivalences. In this note we give an affirmative answer to a question of Alex Dugas about the existence of a $\Gamma$-coring structure on $\Delta$. We do this by showing that $\Delta$ is a Frobenius extension of $\Gamma$., Comment: 4 pages, to appear in Annals Univ. Bucharest
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- 2012
24. Comodules over semiperfect corings
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Caenepeel, S. and Iovanov, M.
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Mathematics - Rings and Algebras ,16W30 - Abstract
We discuss when the Rat functor associated to a coring satisfying the left $\alpha$-condition is exact. We study the category of comodules over a semiperfect coring. We characterize semiperfect corings over artinian rings and over qF-rings., Comment: 18 pages
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- 2011
25. On cross product Hopf algebras
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Bulacu, D., Caenepeel, S., and Torrecillas, B.
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Mathematics - Quantum Algebra ,16T05, 18D18 - Abstract
Let $A$ and $B$ be algebras and coalgebras in a braided monoidal category $\Cc$, and suppose that we have a cross product algebra and a cross coproduct coalgebra structure on $A\ot B$. We present necessary and sufficient conditions for $A\ot B$ to be a bialgebra, and sufficient conditions for $A\ot B$ to be a Hopf algebra. We discuss when such a cross product Hopf algebra is a double cross (co)product, a biproduct, or, more generally, a smash (co)product Hopf algebra. In each of these cases, we provide an explicit description of the associated Hopf algebra projection., Comment: 46 pages
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- 2011
26. The center of the category of bimodules and descent data for non-commutative rings
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Agore, A. L., Caenepeel, S., and Militaru, G.
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Mathematics - Quantum Algebra ,Mathematics - Rings and Algebras ,16T10, 16T05, 16S40 - Abstract
Let $A$ be an algebra over a commutative ring $k$. We compute the center of the category of $A$-bimodules. There are six isomorphic descriptions: the center equals the weak center, and can be described as categories of noncommutative descent data, comodules over the Sweedler canonical $A$-coring, Yetter-Drinfeld type modules or modules with a flat connection from noncommutative differential geometry. All six isomorphic categories are braided monoidal categories: in particular, the category of comodules over the Sweedler canonical $A$-coring $A \ot A$ is braided monoidal. We provide several applications: for instance, if $A$ is finitely generated projective over $k$ then the category of left End_k(A)$-modules is braided monoidal and we give an explicit description of the braiding in terms of the finite dual basis of $A$. As another application, new families of solutions for the quantum Yang-Baxter equation are constructed: they are canonical maps $\Omega$ associated to any right comodule over the Sweedler canonical coring $A \ot A$ and satisfy the condition $\Omega^3 = \Omega$. Explicit examples are provided., Comment: 14 pages; to appear in J. Algebra Appl
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- 2011
27. Braidings on the category of bimodules, Azumaya algebras and epimorphisms of rings
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Agore, A. L., Caenepeel, S., and Militaru, G.
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Mathematics - Quantum Algebra ,Mathematics - Rings and Algebras ,16T10, 16T05, 16S40 - Abstract
Let $A$ be an algebra over a commutative ring $k$. We prove that braidings on the category of $A$-bimodules are in bijective correspondence to canonical R-matrices, these are elements in $A\ot A\ot A$ satisfying certain axioms. We show that all braidings are symmetries. If $A$ is commutative, then there exists a braiding on ${}_A\Mm_A$ if and only if $k\to A$ is an epimorphism in the category of rings, and then the corresponding $R$-matrix is trivial. If the invariants functor $G = (-)^A:\{}_A\Mm_A\to \Mm_k$ is separable, then $A$ admits a canonical R-matrix; in particular, any Azumaya algebra admits a canonical R-matrix. Working over a field, we find a remarkable new characterization of central simple algebras: these are precisely the finite dimensional algebras that admit a canonical R-matrix. Canonical R-matrices give rise to a new class of examples of simultaneous solutions for the quantum Yang-Baxter equation and the braid equation., Comment: 12 pages; final version, to appear in Appl. Cat. Structures
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- 2011
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28. On integrals and cointegrals for quasi-Hopf algebras
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Bulacu, D. and Caenepeel, S.
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Mathematics - Quantum Algebra ,16T05 - Abstract
Using the machinery provided by a Frobenius algebra we show how the antipode of a quasi-Hopf algebra $H$ carries out left or right cointegrals for $H$. These formulas will allow us to find out the explicit form of an integral and a cointegral for the quantum double $D(H)$ of $H$ in terms of those of $H$, and so to answer to a conjecture of Hausser and Nill raised at the end of the nineties., Comment: 29 pages, to appear in J. Algebra
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- 2011
29. Weak bialgebras and monoidal categories
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Böhm, G., Caenepeel, S., and Janssen, K.
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Mathematics - Quantum Algebra ,16T05 - Abstract
We study monoidal structures on the category of (co)modules over a weak bialgebra. Results due to Nill and Szlach\'anyi are unified and extended to infinite algebras. We discuss the coalgebra structure on the source and target space of a weak bialgebra., Comment: 23 pages, to appear in Comm. Algebra
- Published
- 2011
30. A monoidal structure on the category of relative Hopf modules
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Bulacu, D. and Caenepeel, S.
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Mathematics - Category Theory ,16T05, 18D10 - Abstract
Let $B$ be a bialgebra, and $A$ a left $B$-comodule algebra in a braided monoidal category $\Cc$, and assume that $A$ is also a coalgebra, with a not-necessarily associative or unital left $B$-action. Then we can define a right $A$-action on the tensor product of two relative Hopf modules, and this defines a monoidal structure on the category of relative Hopf modules if and only if $A$ is a bialgebra in the category of left Yetter-Drinfeld modules over $B$. Some examples are given., Comment: 17 pages
- Published
- 2010
31. Algebras graded by discrete Doi-Hopf data and the Drinfeld double of a Hopf group-coalgebra
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Bulacu, D. and Caenepeel, S.
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Mathematics - Rings and Algebras ,16T05 - Abstract
We study Doi-Hopf data and Doi-Hopf modules for Hopf group-coalgebras. We introduce modules graded by a discrete Doi-Hopf datum; to a Doi-Hopf datum over a Hopf group coalgebra, we associate an algebra graded by the underlying discrete Doi-Hopf datum, using a smash product type construction. The category of Doi-Hopf modules is then isomorphic to the category of graded modules over this algebra. This is applied to the category of Yetter-Drinfeld modules over a Hopf group coalgebra, leading to the construction of the Drinfeld double. It is shown that this Drinfeld double is a quasitriangular graded Hopf algebra., Comment: 34 pages
- Published
- 2010
32. Hopf-Galois extensions and isomorphisms of small categories
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Caenepeel, S.
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Mathematics - Rings and Algebras ,16W30, 16D90 - Abstract
We associate two linear categories with two objects to a module over the subalgebra of coinvariants of a Hopf-Galois extension, and prove that they are isomorphic. The structure Theorem for cleft extensions, and the Militaru \cStefan lifting Theorem can be obtained using these isomorphisms., Comment: 21 pages
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- 2010
33. The braided monoidal structures on the category of vector spaces graded by the Klein group
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Bulacu, D., Caenepeel, S., and Torrecillas, B.
- Subjects
Mathematics - Quantum Algebra ,Mathematics - Rings and Algebras ,16W30 - Abstract
Let $k$ be a field, $k^*=k\setminus\{0\}$ and $C_2$ the cyclic group of order 2. In this note we compute all the braided monoidal structures on the category of $k$-vector spaces graded by the Klein group $C_2\times C_2$. Actually, for the monoidal structures we will compute the explicit form of the 3-cocycles on $C_2\times C_2$ with coefficients in $k^*$, while for the braided monoidal structures we will compute the explicit form of the abelian 3-cocycles on $C_2\times C_2$ with coefficients in $k^*$. In particular, this will allow us to produce examples of quasi-Hopf algebras and weak braided Hopf algebras, out of the vector space $k[C_2\times C_2]$., Comment: 22 pages
- Published
- 2009
34. Monoidal Hom-Hopf algebras
- Author
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Caenepeel, S. and Goyvaerts, I.
- Subjects
Mathematics - Rings and Algebras ,Mathematics - Category Theory ,16W30 - Abstract
Hom-structures (Lie algebras, algebras, coalgebras, Hopf algebras) have been investigated in the literature recently. We study Hom-structures from the point of view of monoidal categories; in particular, we introduce a symmetric monoidal category such that Hom-algebras coincide with algebras in this monoidal category, and similar properties for coalgebras, Hopf algebras and Lie algebras., Comment: 25 pages; extended version: compared to the version that appeared in Comm. Algebra, the Section Preliminary Results and Remarks 5.1 and 6.1 have been added
- Published
- 2009
- Full Text
- View/download PDF
35. Dysbiosis and Associated Stool Features Improve Prediction of Response to Biological Therapy in Inflammatory Bowel Disease.
- Author
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Caenepeel, Clara, Falony, Gwen, Machiels, Kathleen, Verstockt, Bram, Goncalves, Pedro J., Ferrante, Marc, Sabino, João, Raes, Jeroen, Vieira-Silva, Sara, and Vermeire, Séverine
- Abstract
Dysbiosis of the gut microbiota is considered a key contributor to inflammatory bowel disease (IBD) etiology. Here, we investigated potential associations between microbiota composition and the outcomes to biological therapies. The study prospectively recruited 296 patients with active IBD (203 with Crohn's disease, 93 with ulcerative colitis) initiating biological therapy. Quantitative microbiome profiles of pretreatment and posttreatment fecal samples were obtained combining flow cytometry with 16S amplicon sequencing. Therapeutic response was assessed by endoscopy, patient-reported outcomes, and changes in fecal calprotectin. The effect of therapy on microbiome variation was evaluated using constrained ordination methods. Prediction of therapy outcome was performed using logistic regression with 5-fold cross-validation. At baseline, 65.9% of patients carried the dysbiotic Bacteroides2 (Bact2) enterotype, with a significantly higher prevalence among patients with ileal involvement (76.8%). Microbiome variation was associated with the choice of biological therapy rather than with therapeutic outcome. Only anti–tumor necrosis factor-α treatment resulted in a microbiome shift away from Bact2, concomitant with an increase in microbial load and butyrogen abundances and a decrease in potentially opportunistic Veillonella. Remission rates for patients hosting Bact2 at baseline were significantly higher with anti–tumor necrosis factor-α than with vedolizumab (65.1% vs 35.2%). A prediction model, based on anthropometrics and clinical data, stool features (microbial load, moisture, and calprotectin), and Bact2 detection predicted treatment outcome with 73.9% accuracy for specific biological therapies. Fecal characterization based on microbial load, moisture content, calprotectin concentration, and enterotyping may aid in the therapeutic choice of biological therapy in IBD. [Display omitted] Clinical data, stool features, and detection of microbiome dysbiosis were used to generate a model that allowed prediction of anti–tumor necrosis factor-α, vedolizumab or ustekinumab treatment outcome in patients with inflammatory bowel diseases with 73.9% accuracy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. Hopf-Galois extensions and an exact sequence for $H$-Picard groups
- Author
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Caenepeel, S. and Marcus, A.
- Subjects
Mathematics - Rings and Algebras ,16W30 ,16D90 - Abstract
Let $H$ be a Hopf algebra, and $A$ an $H$-Galois extension. We investigate $H$-Morita autoequivalences of $A$, introduce the concept of $H$-Picard group, and we establish an exact sequence linking the $H$-Picard group of $A$ and the Picard group of $A^{{\rm co}H}$., Comment: 35 pages; to appear in J. Algebra
- Published
- 2008
37. Monadic approach to Galois descent and cohomology
- Author
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Borceux, F., Caenepeel, S., and Janelidze, G.
- Subjects
Mathematics - Category Theory ,18C15 ,18D10 - Abstract
We describe a simplified categorical approach to Galois descent theory. It is well known that Galois descent is a special case of Grothendieck descent, and that under mild additional conditions the category of Grothendieck descent data coincides with the Eilenberg-Moore category of algebras over a suitable monad. This also suggests using monads directly, and our monadic approach to Galois descent makes no reference to Grothendieck descent theory at all. In order to make Galois descent constructions perfectly clear, we also describe their connections with some other related constructions of categorical algebra, and make various explicit calculations, especially with 1-cocycles and 1-dimensional non-abelian cohomology, usually omitted in the literature., Comment: 25 pages
- Published
- 2008
38. Strong group coalgebras
- Author
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Caenepeel, S. and Janssen, K.
- Subjects
Mathematics - Rings and Algebras ,16W30 ,16W50 - Abstract
We introduce strong group coalgebras, as a generalization of strongly graded coalgebras. We give several characterizations, and study two special types of strong group coalgebras, namely cleft group algebras (or crossed coproduct group coalgebras) and smash coproduct group coalgebras., Comment: 16 pages
- Published
- 2008
39. Involutory quasi-Hopf algebras
- Author
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Bulacu, D., Caenepeel, S., and Torrecillas, B.
- Subjects
Mathematics - Quantum Algebra ,16W30 - Abstract
We introduce and investigate the basic properties of an involutory (dual) quasi-Hopf algebra. We also study the representations of an involutory quasi-Hopf algebra and prove that an involutory dual quasi-Hopf algebra with non-zero integral is cosemisimple., Comment: 26 pages
- Published
- 2007
40. Group corings
- Author
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Caenepeel, S., Janssen, K., and Wang, S. H.
- Subjects
Mathematics - Rings and Algebras ,16W30, 16W50 - Abstract
We introduce group corings, and study functors between categories of comodules over group corings, and the relationship to graded modules over graded rings. Galois group corings are defined, and a Structure Theorem for the $G$-comodules over a Galois group coring is given. We study (graded) Morita contexts associated to a group coring. Our theory is applied to group corings associated to a comodule algebra over a Hopf group coalgebra., Comment: 38 pages
- Published
- 2007
41. Partial (co)actions of Hopf algebras and partial Hopf-Galois theory
- Author
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Caenepeel, S. and Janssen, K.
- Subjects
Mathematics - Rings and Algebras ,Mathematics - Quantum Algebra ,16W30 - Abstract
We introduce partial (co)actions of a Hopf algebra $H$ on an algebra. To this end, we introduce first the notion of lax coring, generalizing Wisbauer's notion of weak coring. We also have the dual notion of lax ring. Several duality results are given, and we develop Galois theory for partial $H$-comodule algebras., Comment: 22 pages
- Published
- 2006
42. Morita equivalences induced by bimodules over Hopf-Galois extensions
- Author
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Caenepeel, S., Crivei, S., Marcus, A., and Takeuchi, M.
- Subjects
Mathematics - Rings and Algebras ,16W30 ,16D90 - Abstract
Let $H$ be a Hopf algebra, and $A,B$ be $H$-Galois extensions. We investigate the category ${}_A\mathcal{M}_B^H$ of relative Hopf bimodules, and the Morita equivalences between $A$ and $B$ induced by them., Comment: 32 pages
- Published
- 2006
43. Constructing infinite Comatrix Corings from colimits
- Author
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Caenepeel, S., De Groot, E., and Vercruysse, J.
- Subjects
Mathematics - Rings and Algebras ,16W30 - Abstract
We propose a class of infinite comatrix corings, and describe them as colimits of systems of usual comatrix corings. The infinite comatrix corings of El Kaoutit and G\'omez Torrecillas are special cases of our construction, which in turn can be considered as a special case of the comatrix corings introduced recently by G\'omez Torrecillas an the third author., Comment: 23 pages, some corrections and additions to the previous version, and a renumbering of theorems in section 4
- Published
- 2005
44. The Brauer group of Azumaya corings and the second cohomology group
- Author
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Caenepeel, S. and Femic, B.
- Subjects
Mathematics - Rings and Algebras ,16W30 - Abstract
Let $R$ be a commutative ring. An Azumaya coring consists of a couple $(S,\Cc)$, with $S$ a faithfully flat commutative $R$-algebra, and an $S$-coring $\Cc$ satisfying certain properties. If $S$ is faithfully projective, then the dual of $\Cc$ is an Azumaya algebra. Equivalence classes of Azumaya corings form an abelian group, called the Brauer group of Azumaya corings. This group is canonically isomorphic to the second flat cohomology group. We also give algebraic interpretations of the second Amitsur cohomology group and the first Villamayor-Zelinsky cohomology group in terms of corings., Comment: 26 pages
- Published
- 2005
45. Duality for finite Hopf algebras explained by corings
- Author
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Caenepeel, S., Quinn, D., and Raianu, S.
- Subjects
Mathematics - Rings and Algebras ,Mathematics - Quantum Algebra ,16W30 - Abstract
We give a coring version for the duality theorem for actions and coactions of a finitely generated projective Hopf algebra. We also provide a coring analogue for a theorem of H.-J. Schneider, which generalizes and unifies the duality theorem for finite Hopf algebras and its refinements., Comment: 7 pages
- Published
- 2005
46. On the cohomology of relative Hopf modules
- Author
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Caenepeel, S. and Guédénon, T.
- Subjects
Mathematics - Rings and Algebras ,16W30 - Abstract
Let $H$ be a Hopf algebra over a field $k$, and $A$ an $H$-comodule algebra. The categories of comodules and relative Hopf modules are then Grothendieck categories with enough injectives. We study the derived functors of the associated Hom functors, and of the coinvariants functor, and discuss spectral sequences that connect them. We also discuss when the coinvariants functor preserves injectives., Comment: 23 pages
- Published
- 2005
47. Fully bounded noetherian rings and Frobenius extensions
- Author
-
Caenepeel, S. and Guédénon, T.
- Subjects
Mathematics - Rings and Algebras ,16W30 - Abstract
Let $i: A\to R$ be a ring morphism, and $\chi: R\to A$ a right $R$-linear map with $\chi(\chi(r)s)=\chi(rs)$ and $\chi(1_R)=1_A$. If $R$ is a Frobenius $A$-ring, then we can define a trace map $\tr: A\to A^R$. If there exists an element of trace 1 in $A$, then $A$ is right FBN if and only if $A^R$ is right FBN and $A$ is right noetherian. The result can be generalized to the case where $R$ is an $I$-Frobenius $A$-ring, and the condition on the trace can be replaced by a weaker condition. We recover results of Garc\'{\i}a and del R\'{\i}o and by D\v{a}sc\v{a}lescu, Kelarev and Torrecillas on actions of group and Hopf algebras on FBN rings as special cases. We also obtain applications to extensions of Frobenius algebras, and to Frobenius corings with a grouplike element., Comment: 15 pages
- Published
- 2005
48. The relative Picard group of a comodule algebra and Harrison cohomology
- Author
-
Caenepeel, S. and Guedenon, T.
- Subjects
Mathematics - Rings and Algebras ,16W30 - Abstract
Let $A$ be a commutative comodule algebra over a commutative bialgebra $H$. The group of invertible relative Hopf modules maps to the Picard group of $A$, and the kernel is described as a quotient group of the group of invertible grouplike elements of the coring $A\ot H$, or as a Harrison cohomology group. Our methods are based on elementary $K$-theory. The Hilbert 90 Theorem follows as a corollary. The part of the Picard group of the coinvariants that becomes trivial after base extension embeds in the Harrison cohomology group, and the image is contained in a well-defined subgroup $E$. It equals $E$ if $H$ is a cosemisimple Hopf algebra over a field., Comment: 12 pages
- Published
- 2004
49. Yetter-Drinfeld modules over weak Hopf algebras and the center construction
- Author
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Caenepeel, S., Wang, Dingguo, and Yin, Yanmin
- Subjects
Mathematics - Quantum Algebra ,Mathematics - Rings and Algebras ,16W30 - Abstract
We introduce Yetter-Drinfeld modules over a weak Hopf algebra $H$, and show that the category of Yetter-Drinfeld modules is isomorphic to the center of the category of $H$-modules. The categories of left-left, left-right, right-left and right-right Yetter-Drinfeld modules are isomorphic as braided monoidal categories. Yetter-Drinfeld modules can be viewed as weak Doi-Hopf modules, and, a fortiori, as weak entwined modules. If $H$ is finitely generated and projective, then we introduce the Drinfeld double using duality results between entwining structures and smash product structures, and show that the category of Yetter-Drinfeld modules is isomorphic to the category of modules over the Drinfeld double., Comment: 22 pages
- Published
- 2004
50. A categorical approach to Turaev's Hopf group-coalgebras
- Author
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Caenepeel, S. and De Lombaerde, M.
- Subjects
Mathematics - Quantum Algebra ,Mathematics - Rings and Algebras ,16W30 - Abstract
We show that Turaev's group-coalgebras and Hopf group-coalgebras are coalgebras and Hopf algebras in a symmetric monoidal category, which we call the Turaev category. A similar result holds for group-algebras and Hopf group-algebras. As an application, we give an alternative approach to Virelizier's version of the Fundamental Theorem for Hopf algebras. We introduce Yetter-Drinfeld modules over Hopf group-coalgebras using the center construction., Comment: 22 pages
- Published
- 2004
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