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2. Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non-Muscle-Invasive Bladder Cancer

Author

Pietzak, Eugene J, Whiting, Karissa, Srinivasan, Preethi, Bandlamudi, Chaitanya, Khurram, Aliya, Joseph, Vijai, Walasek, Aleksandra, Bochner, Emily, Clinton, Timothy, Almassi, Nima, Truong, Hong, de Jesus Escano, Manuel R, Wiseman, Michal, Mandelker, Diana, Kemel, Yelena, Zhang, Liying, Walsh, Michael F, Cadoo, Karen A, Coleman, Jonathan A, Al-Ahmadie, Hikmat, Rosenberg, Jonathan E, Iyer, Gopakumar V, Solit, David B, Ostrovnaya, Irina, Offit, Kenneth, Robson, Mark E, Stadler, Zsofia K, Berger, Michael F, Bajorin, Dean F, Carlo, Maria, and Bochner, Bernard H

Subjects
Prevention, Cancer, Clinical Trials and Supportive Activities, Urologic Diseases, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Adjuvants, Immunologic, BCG Vaccine, Carcinoma, Transitional Cell, Germ Cells, Humans, Neoplasm Invasiveness, Urinary Bladder Neoplasms, Xeroderma Pigmentosum Group D Protein, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeIdentification of inherited germline variants can guide personalized cancer screening, prevention, and treatment. Pathogenic and likely pathogenic (P/LP) germline variants in cancer predisposition genes are frequent among patients with locally advanced or metastatic urothelial carcinoma, but their prevalence and significance in patients with non-muscle-invasive bladder cancer (NMIBC), the most common form of urothelial carcinoma, is understudied.Experimental designGermline analysis was conducted on paired tumor/normal sequencing results from two distinct cohorts of patients initially diagnosed with NMIBC. Associations between clinicopathologic features and clinical outcomes with the presence of P/LP germline variants in ≥76 hereditary cancer predisposition genes were analyzed.ResultsA similar frequency of P/LP germline variants were seen in our two NMIBC cohorts [12% (12/99) vs. 8.7% (10/115), P = 0.4]. In the combined analysis, P/LP germline variants were found only in patients with high-grade NMIBC (22/163), but none of the 46 patients with low-grade NMIBC (13.5% vs. 0%, P = 0.005). Fifteen (9.2%) patients with high-grade NMIBC had P/LP variants in DNA damage response genes, most within the nucleotide excision repair (ERCC2/3) and homologous recombination repair (BRCA1, NBN, RAD50) pathways. Contrary to prior reports in patients with NMIBC not receiving Bacillus Calmette-Guerin (BCG), P/LP germline variants were not associated with worse recurrence-free or progression-free survival in patients treated with BCG or with risk of developing upper tract urothelial carcinoma.ConclusionsOur results support offering germline counseling and testing for all patients with high-grade bladder cancer, regardless of initial tumor stage. Therapeutic strategies that target impaired DNA repair may benefit patients with high-grade NMIBC.

Published
2022

3. Unravelling the biological and clinical challenges of circulating tumour cells in epithelial ovarian carcinoma

Author

Lewis, Faye, Beirne, James, Henderson, Brian, Norris, Lucy, Cadoo, Karen, Kelly, Tanya, Martin, Cara, Hurley, Sinéad, Kanjuga, Marika, O'Driscoll, Lorraine, Gately, Kathy, Oner, Ezgi, Saini, Volga M., Brooks, Doug, Selemidis, Stavros, Kamran, Waseem, Haughey, Niamh, Maguire, Patrick, O'Gorman, Catherine, Saadeh, Feras Abu, Ward, Mark P., O'Leary, John J., and O'Toole, Sharon A.

Published
2024
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4. The context-specific role of germline pathogenicity in tumorigenesis

Author

Srinivasan, Preethi, Bandlamudi, Chaitanya, Jonsson, Philip, Kemel, Yelena, Chavan, Shweta S, Richards, Allison L, Penson, Alexander V, Bielski, Craig M, Fong, Christopher, Syed, Aijazuddin, Jayakumaran, Gowtham, Prasad, Meera, Hwee, Jason, Sumer, Selcuk Onur, de Bruijn, Ino, Li, Xiang, Gao, JianJiong, Schultz, Nikolaus, Cambria, Roy, Galle, Jesse, Mukherjee, Semanti, Vijai, Joseph, Cadoo, Karen A, Carlo, Maria I, Walsh, Michael F, Mandelker, Diana, Ceyhan-Birsoy, Ozge, Shia, Jinru, Zehir, Ahmet, Ladanyi, Marc, Hyman, David M, Zhang, Liying, Offit, Kenneth, Robson, Mark E, Solit, David B, Stadler, Zsofia K, Berger, Michael F, and Taylor, Barry S

Subjects
Biological Sciences, Genetics, Human Genome, Rare Diseases, Cancer, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Carcinogenesis, DNA Copy Number Variations, DNA Mismatch Repair, Genetic Predisposition to Disease, Germ-Line Mutation, Heterozygote, Humans, Neoplasms, Phenotype, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Human cancers arise from environmental, heritable and somatic factors, but how these mechanisms interact in tumorigenesis is poorly understood. Studying 17,152 prospectively sequenced patients with cancer, we identified pathogenic germline variants in cancer predisposition genes, and assessed their zygosity and co-occurring somatic alterations in the concomitant tumors. Two major routes to tumorigenesis were apparent. In carriers of pathogenic germline variants in high-penetrance genes (5.1% overall), lineage-dependent patterns of biallelic inactivation led to tumors exhibiting mechanism-specific somatic phenotypes and fewer additional somatic oncogenic drivers. Nevertheless, 27% of cancers in these patients, and most tumors in patients with pathogenic germline variants in lower-penetrance genes, lacked particular hallmarks of tumorigenesis associated with the germline allele. The dependence of tumors on pathogenic germline variants is variable and often dictated by both penetrance and lineage, a finding with implications for clinical management.

Published
2021

5. Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination.

Author

Setton, Jeremy, Selenica, Pier, Mukherjee, Semanti, Shah, Rachna, Pecorari, Isabella, McMillan, Biko, Pei, Isaac X, Kemel, Yelena, Ceyhan-Birsoy, Ozge, Sheehan, Margaret, Tkachuk, Kaitlyn, Brown, David N, Zhang, Liying, Cadoo, Karen, Powell, Simon, Weigelt, Britta, Robson, Mark, Riaz, Nadeem, Offit, Kenneth, Reis-Filho, Jorge S, and Mandelker, Diana

Subjects
Breast Cancer, Rare Diseases, Genetics, Cancer, Biotechnology, Ovarian Cancer, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies
Abstract

Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting another RAD51 paralog gene, RAD51B, are also associated with breast and ovarian cancer. Among 3422 consecutively accrued breast and ovarian cancer patients consented to tumor/germline sequencing, the observed carrier frequency of loss-of-function germline RAD51B variants was significantly higher than control cases from the gnomAD population database (0.26% vs 0.09%), with an odds ratio of 2.69 (95% CI: 1.4-5.3). Furthermore, we demonstrate that tumors harboring biallelic RAD51B alteration are deficient in homologous recombination DNA repair deficiency (HRD), as evidenced by analysis of sequencing data and in vitro functional assays. Our findings suggest that RAD51B should be considered as an addition to clinical germline testing panels for breast and ovarian cancer susceptibility.

Published
2021

8. Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors

Author

Fiala, Elise M, Jayakumaran, Gowtham, Mauguen, Audrey, Kennedy, Jennifer A, Bouvier, Nancy, Kemel, Yelena, Fleischut, Megan Harlan, Maio, Anna, Salo-Mullen, Erin E, Sheehan, Margaret, Arnold, Angela G, Latham, Alicia, Carlo, Maria I, Cadoo, Karen, Murkherjee, Semanti, Slotkin, Emily K, Trippett, Tanya, Glade Bender, Julia, Meyers, Paul A, Wexler, Leonard, Dela Cruz, Filemon S, Cheung, Nai-Kong, Basu, Ellen, Kentsis, Alex, Ortiz, Michael, Francis, Jasmine H, Dunkel, Ira J, Khakoo, Yasmin, Gilheeney, Stephen, Farouk Sait, Sameer, Forlenza, Christopher J, Sulis, Maria, Karajannis, Matthias, Modak, Shakeel, Gerstle, Justin T, Heaton, Todd E, Roberts, Stephen, Yang, Ciyu, Jairam, Sowmya, Vijai, Joseph, Topka, Sabine, Friedman, Danielle N, Stadler, Zsofia K, Robson, Mark, Berger, Michael F, Schultz, Nikolaus, Ladanyi, Marc, O’Reilly, Richard J, Abramson, David H, Ceyhan-Birsoy, Ozge, Zhang, Liying, Mandelker, Diana, Shukla, Neerav N, Kung, Andrew L, Offit, Kenneth, Zehir, Ahmet, and Walsh, Michael F

Subjects
Rare Diseases, Genetic Testing, Genetics, Pediatric, Human Genome, Clinical Research, Pediatric Cancer, Cancer, Aetiology, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Child, Genetic Predisposition to Disease, Germ Cells, Germ-Line Mutation, Humans, Neoplasms, Prospective Studies
Abstract

The spectrum of germline predisposition in pediatric cancer continues to be realized. Here we report 751 solid tumor patients who underwent prospective matched tumor-normal DNA sequencing and downstream clinical use (clinicaltrials.gov NCT01775072). Germline pathogenic and likely pathogenic (P/LP) variants were reported. One or more P/LP variants were found in 18% (138/751) of individuals when including variants in low, moderate, and high penetrance dominant or recessive genes, or 13% (99/751) in moderate and high penetrance dominant genes. 34% of high or moderate penetrance variants were unexpected based on the patient's diagnosis and previous history. 76% of patients with positive results completed a clinical genetics visit, and 21% had at least one relative undergo cascade testing as a result of this testing. Clinical actionability additionally included screening, risk reduction in relatives, reproductive use, and use of targeted therapies. Germline testing should be considered for all children with cancer.

Published
2021

10. The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Author

Figlioli, Gisella, Bogliolo, Massimo, Catucci, Irene, Caleca, Laura, Lasheras, Sandra Viz, Pujol, Roser, Kiiski, Johanna I, Muranen, Taru A, Barnes, Daniel R, Dennis, Joe, Michailidou, Kyriaki, Bolla, Manjeet K, Leslie, Goska, Aalfs, Cora M, Adank, Muriel A, Adlard, Julian, Agata, Simona, Cadoo, Karen, Agnarsson, Bjarni A, Ahearn, Thomas, Aittomäki, Kristiina, Ambrosone, Christine B, Andrews, Lesley, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Arnold, Norbert, Aronson, Kristan J, Arun, Banu K, Asseryanis, Ella, Auber, Bernd, Auvinen, Päivi, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Barwell, Julian, Beane Freeman, Laura E, Beauparlant, Charles Joly, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Berger, Raanan, Bermisheva, Marina, Blanco, Amie M, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Anders, Bojesen, Stig E, Bonanni, Bernardo, Borg, Ake, Brady, Angela F, Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Burwinkel, Barbara, Buys, Saundra S, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A, Campa, Daniele, Campbell, Ian G, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Claes, Kathleen BM, Clarke, Christine L, Collavoli, Anita, Conner, Thomas A, Cox, David G, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, de la Hoya, Miguel, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Dite, Gillian S, Ditsch, Nina, Domchek, Susan M, Dorfling, Cecilia M, dos-Santos-Silva, Isabel, Durda, Katarzyna, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Ellberg, Carolina, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Foulkes, William D, Friebel, Tara M, Friedman, Eitan, Gabrielson, Marike, Gaddam, Pragna, and Gago-Dominguez, Manuela

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Clinical Research, Genetics, Breast Cancer, Cancer, Genetic Testing, 2.1 Biological and endogenous factors, Aetiology, ABCTB Investigators, GEMO Study Collaborators, KConFab, Cancer genetics, Clinical sciences, Oncology and carcinogenesis, Epidemiology
Abstract

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.

Published
2019

13. Mesonephric and mesonephric-like carcinomas of the female genital tract: molecular characterization including cases with mixed histology and matched metastases

Author

da Silva, Edaise M., Fix, Daniel J., Sebastiao, Ana Paula Martins, Selenica, Pier, Ferrando, Lorenzo, Kim, Sarah H., Stylianou, Anthe, Da Cruz Paula, Arnaud, Pareja, Fresia, Smith, Evan S., Zehir, Ahmet, Konner, Jason A., Cadoo, Karen, Reis-Filho, Jorge S., Abu-Rustum, Nadeem R., Mueller, Jennifer J., Weigelt, Britta, and Park, Kay J.

Published
2021
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14. Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes

Author

Moukarzel, Lea A., Da Cruz Paula, Arnaud, Ferrando, Lorenzo, Hoang, Timothy, Sebastiao, Ana Paula Martins, Pareja, Fresia, Park, Kay J., Jungbluth, Achim A., Capella, Gabriel, Pineda, Marta, Levin, Jeffrey D., Abu-Rustum, Nadeem R., Ellenson, Lora H., Bel, August Vidal, Reis-Filho, Jorge S., Matias-Guiu, Xavier, Cadoo, Karen, Stadler, Zsofia K., and Weigelt, Britta

Published
2021
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16. A phase I open-label study of selinexor with paclitaxel and carboplatin in patients with advanced ovarian or endometrial cancers

Author

Rubinstein, Maria M., Grisham, Rachel N., Cadoo, Karen, Kyi, Chrisann, Tew, William P., Friedman, Claire F., O'Cearbhaill, Roisin E., Zamarin, Dmitriy, Zhou, Qin, Iasonos, Alexia, Nikolovski, Ines, Xu, Hongmei, Soldan, Krysten N., Caird, Imogen, Martin, Madhuri, Guillen, Joyce, Eid, Khalil T., Aghajanian, Carol, and Makker, Vicky

Published
2021
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19. A phase 1 dose-escalation study of intraperitoneal cisplatin, intravenous/intraperitoneal paclitaxel, bevacizumab, and olaparib for newly diagnosed ovarian cancer

Author

Cadoo, Karen A., Grisham, Rachel N., O'Cearbhaill, Roisin E., Boucicaut, Nicole N., Henson, Melissa, Iasonos, Alexia, Zhou, Qin, Sarasohn, Debra M., Gallagher, Jacqueline, Kravetz, Sara, Zamarin, Dmitriy, Makker, Vicky, Sabbatini, Paul J., Tew, William P., Aghajanian, Carol, and Konner, Jason A.

Published
2020
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20. Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer

Author

Stasenko, Marina, Tunnage, Irina, Ashley, Charles W., Rubinstein, Maria M., Latham, Alicia J., Da Cruz Paula, Arnaud, Mueller, Jennifer J., Leitao, Mario M., Jr., Friedman, Claire F., Makker, Vicky, Soslow, Robert A., DeLair, Deborah F., Hyman, David M., Zamarin, Dimitriy, Alektiar, Kaled M., Aghajanian, Carol A., Abu-Rustum, Nadeem R., Weigelt, Britta, and Cadoo, Karen A.

Published
2020
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24. Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial

Author

Konstantinopoulos, Panagiotis A, Barry, William T, Birrer, Michael, Westin, Shannon N, Cadoo, Karen A, Shapiro, Geoffrey I, Mayer, Erica L, O'Cearbhaill, Roisin E, Coleman, Robert L, Kochupurakkal, Bose, Whalen, Christin, Curtis, Jennifer, Farooq, Sarah, Luo, Weixiu, Eismann, Julia, Buss, Mary K, Aghajanian, Carol, Mills, Gordon B, Palakurthi, Sangeetha, Kirschmeier, Paul, Liu, Joyce, Cantley, Lewis C, Kaufmann, Scott H, Swisher, Elizabeth M, D'Andrea, Alan D, Winer, Eric, Wulf, Gerburg M, and Matulonis, Ursula A

Published
2019
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25. Early disease progression and treatment discontinuation in patients with advanced ovarian cancer receiving immune checkpoint blockade

Author

Boland, Julia L., Zhou, Qin, Martin, Madhuri, Callahan, Margaret K., Konner, Jason, O'Cearbhaill, Roisin E., Friedman, Claire F., Tew, William, Makker, Vicky, Grisham, Rachel N., Hensley, Martee L., Zecca, Nicholas, Iasonos, Alexia E., Snyder, Alexandra, Hyman, David M., Sabbatini, Paul, Aghajanian, Carol, Cadoo, Karen A., and Zamarin, Dmitriy

Published
2019
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27. #836 Liquid biopsy isolation of circulating tumour cells from epithelial ovarian cancer patients and their prognostic significance

Author

Ward, Mark P, primary, Lewis, Faye, additional, O’Gorman, Catherine, additional, Kelly, Tanya E, additional, Mohamed, Bashir M, additional, Henderson, Brian, additional, Hurley, Sined, additional, O’Connor, Roisin, additional, Brooks, Robert D, additional, Brooks, Doug A, additional, Selemidis, Stavros, additional, Maguire, Patrick, additional, Kamran, Waseem, additional, Beirne, James P, additional, Saadeh, Feras A, additional, Cadoo, Karen, additional, Norris, Lucy A, additional, Martin, Cara, additional, O’Toole, Sharon A, additional, and O’Leary, John J, additional

Published
2023
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28. Contributors

Author

Abbruzzese, James L., primary, Abdel-Wahab, Omar, additional, Abou-Alfa, Ghassan K., additional, Abrahm, Janet L., additional, Abrams, Jeffrey S., additional, Abramson, Jeremy S., additional, Aisner, Dara L., additional, Alonso-Basanta, Michelle, additional, Anampa, Jesus, additional, Anderson, Megan E., additional, Antonarakis, Emmanuel S., additional, Aplenc, Richard, additional, Appelbaum, Frederick R., additional, Araujo, Luiz H., additional, Asban, Ammar, additional, Ashwood, Edward, additional, Awan, Farrukh T., additional, Aylward, Juliet L., additional, Balar, Arjun V., additional, Balentine, Courtney J., additional, Barta, Stefan K., additional, Bartlett, Nancy, additional, Basen-Engquist, Karen, additional, Beaupin, Lynda Kwon, additional, Berkowitz, Ross S., additional, Berry, Donald A., additional, Bevers, Therese, additional, Boggess, John F., additional, Brahmer, Julie R., additional, Brown, Janet, additional, Brown, Karen, additional, Brown, Powel, additional, Browner, Ilene, additional, Bunn, Paul A., additional, Burns, William R., additional, Byrd, John C., additional, Cadoo, Karen, additional, Carbone, David P., additional, Carter, H. Ballentine, additional, Castillo, Jorge J., additional, Chang, Alfred E., additional, Chang, Eric, additional, Chanock, Stephen J., additional, Chapuy, Claudia I., additional, Chauhan, Vikash P., additional, Chen, Herbert, additional, Chen, Ronald C., additional, Cheung, Nai-Kong V., additional, Choe, Jennifer H., additional, Christian, Michaele C., additional, Cinciripini, Paul M., additional, Clarke, Michael F., additional, Coleman, Robert E., additional, Coleman, Robert L., additional, Coletta, Adriana M., additional, Collins, Jerry M., additional, Connors, Jean M., additional, Cools, Michael, additional, Coombes, Kevin R., additional, Cortes, Jorge, additional, Costa, Mauro W., additional, Covey, Anne, additional, Cowan, Kenneth H., additional, Crane, Christopher H., additional, Crawford, Jeffrey, additional, Crooks, Kristy, additional, Culkin, Daniel J., additional, Czito, Brian G., additional, Dalerba, Piero, additional, Dalmau, Josep, additional, Dang, Mai, additional, D'Angelica, Michael, additional, Davies, Kurtis D., additional, Davis, Myrtle, additional, Dea, Nicolas, additional, De Jesus-Acosta, Ana, additional, DeMarzo, Angelo M., additional, DeWeese, Theodore L., additional, Diehn, Maximilian, additional, Digumarthy, Subba R., additional, Dispenzieri, Angela, additional, Do, Khanh T., additional, Dobrenkov, Konstantin, additional, Dome, Jeffrey S., additional, Doroshow, James H., additional, Dorsey, Jay F., additional, Dubard-Gault, Marianne, additional, DuBois, Steven G., additional, Duda, Dan G., additional, Dunlop, Malcolm, additional, Duska, Linda R., additional, Duvic, Madeleine, additional, El Dika, Imane, additional, El-Serag, Hashem, additional, Engelmann, Jeffrey M., additional, Ettinger, David S., additional, Fashoyin-Aje, Lola A., additional, Fearon, Eric R., additional, Ford, James M., additional, Franklin, Wilbur A., additional, Freer, Phoebe E., additional, Freidlin, Boris, additional, Freifeld, Alison G., additional, Friedlander, Terence W., additional, Friedman, Debra L., additional, Fuller, Arian F., additional, Galluzzi, Lorenzo, additional, Gebhardt, Mark C., additional, George, Daniel J., additional, Geyer, Mark B., additional, Giaccia, Amato J., additional, Gilbert, Mark R., additional, Goldner, Whitney, additional, Goldstein, Donald P., additional, Goodman, Annekathryn, additional, Goodman, Karyn A., additional, Gordon, Kathleen, additional, Graeff-Armas, Laura, additional, Greenstein, Alexander J., additional, Grossman, Stuart A., additional, Grupp, Stephan, additional, Gupta, Arjun, additional, Haider, Irfanullah, additional, Haigentz, Missak, additional, Hainsworth, John D., additional, Haithcock, Benjamin E., additional, Hallemeier, Christopher L., additional, Hanash, Samir, additional, Hanrahan, Aphrothiti J., additional, Harding, James, additional, Harrison, Michael R., additional, Hasham, Muneer G., additional, Hawk, Ernest, additional, Hayman, Jonathan, additional, Heinlen, Jonathan E., additional, Henry, N. Lynn, additional, Herman, Joseph, additional, Hobbs, Brian P., additional, Holen, Ingunn, additional, Horn, Leora, additional, Horowitz, Neil S., additional, Horwitz, Steven M., additional, Houghton, Odette, additional, Howard, Scott C., additional, Hudis, Clifford A., additional, Hunger, Stephen P., additional, Hurria, Arti, additional, Ilson, David H., additional, Im, Annie, additional, Iyer, Gopa, additional, Jaffee, Elizabeth M., additional, Jagsi, Reshma, additional, Jain, Rakesh K., additional, Jarnagin, William, additional, Jatoi, Aminah, additional, Jhingran, Anuja, additional, Johnson, David H., additional, Johnston, Brian, additional, Johnston, Patrick G., additional, Judy, Kevin D., additional, Kachnic, Lisa A., additional, Kaidar-Person, Orit, additional, Kalva, Sanjeeva, additional, Kamin, Deborah Y., additional, Kantarjian, Hagop, additional, Karakousis, Giorgos, additional, Karam-Hage, Maher, additional, Kaskas, Nadine M., additional, Kastan, Michael B., additional, Katabi, Nora, additional, Kaul, Daniel R., additional, Kelley, Scott R., additional, Kemeny, Nancy, additional, Kent, Erin E., additional, Kepp, Oliver, additional, Khagi, Simon, additional, Kilgore, Joshua E., additional, Kim, D. Nathan, additional, Kleinschmidt-DeMasters, Bette K., additional, Korn, Edward L., additional, Kroemer, Guido, additional, Ku, Geoffrey Y., additional, Kummar, Shivaani, additional, Ky, Bonnie, additional, Laheru, Daniel A., additional, Lambert, Paul F., additional, Lawler, Mark, additional, Le-Rademacher, Jennifer G., additional, Lee, John Y.K., additional, Lee, Nancy Y., additional, Lee, Susanna L., additional, Leeman, Jonathan E., additional, Linkermann, Andreas, additional, Liu, Jinsong, additional, Lo, Simon, additional, Locasale, Jason W., additional, Loprinzi, Charles L., additional, Lowery, Maeve, additional, Ludwig, Emmy, additional, Lunning, Matthew A., additional, Lustig, Robert A., additional, Machtay, Mitchell, additional, Mackall, Crystal, additional, Mahvi, David A., additional, Mahvi, David M., additional, Maity, Amit, additional, Majithia, Neil, additional, Malumbres, Marcos, additional, Maresso, Karen Colbert, additional, Martin, John D., additional, Matsuo, Koji, additional, Matthews, Natalie H., additional, Mauro, Lauren, additional, Mayer, R. Samuel, additional, McCaskill-Stevens, Worta, additional, McNamara, Megan A., additional, Mehta-Shah, Neha, additional, Merritt, Robert E., additional, Milowsky, Matthew I., additional, Minasian, Lori M., additional, Mitchell, Tara C., additional, Mitsis, Demytra, additional, Mollica, Michelle, additional, Mooney, Margaret, additional, Moustafa, Farah, additional, Nabati, Lida, additional, Naidoo, Jarushka, additional, Narang, Amol, additional, Nelson, Heidi, additional, Nelson, William G., additional, Nesbit, Suzanne, additional, Niglas, Mark, additional, O'Connor, Tracey, additional, Offit, Kenneth, additional, Onciu, Mihaela, additional, O’Reilly, Eileen M., additional, Ostrander, Elaine A., additional, Pappas-Taffer, Lisa, additional, Pardoll, Drew, additional, Park, Jae H., additional, Patel, Anery, additional, Patel, Anish J., additional, Patierno, Steven R., additional, Pavletic, Steven Z., additional, Phillips, Peter C., additional, Post, Miriam D., additional, Pruitt, Amy A., additional, Querfeld, Christiane, additional, Rabius, Vance A., additional, Rajkumar, S. Vincent, additional, Ramadan, Mohammad O., additional, Rankin, Erinn B., additional, Reddy, Sushanth, additional, Reid, Michael A., additional, Reznik, Scott, additional, Rizack, Tina, additional, Robinson, Jason D., additional, Robinson-Bostom, Leslie, additional, Rodriguez-Galindo, Carlos, additional, Romesser, Paul B., additional, Rosen, Steven T., additional, Rosenfeld, Myrna R., additional, Rosenthal, Nadia, additional, Ross, Meredith, additional, Rowland, Julia H., additional, Russell, Anthony H., additional, Sabel, Michael S., additional, Sahgal, Arjun, additional, Salinas, Ryan D., additional, Salo-Mullen, Erin E., additional, Salto-Tellez, Manuel, additional, Sanderson, Sydney M., additional, Sandlund, John T., additional, Santana, Victor M., additional, Savage, Michelle, additional, Schreiber, Eric C., additional, Schuchter, Lynn, additional, Schultz, Liora, additional, Seiden, Michael V., additional, Sellers, Morgan M., additional, Shah, Payal D., additional, Shia, Jinru, additional, Shilo, Konstantin, additional, Small, Eric, additional, Smith, Angela B., additional, Snow, Stephen N., additional, Solit, David B., additional, Sood, Anil K., additional, Soto-Perez-de-Celis, Enrique, additional, Sparano, Joseph A., additional, Spiegelman, Vladimir S., additional, Spunt, Sheri L., additional, Stadler, Zsofia K., additional, Steensma, David P., additional, Stone, Richard M., additional, Stranne, Steven Kent, additional, Stratton, Kelly, additional, Sugden, Bill, additional, Swanson, Andrew M., additional, Tallman, Martin S., additional, Talmadge, James E., additional, Teachey, David T., additional, Teba, Catalina V., additional, Tefferi, Ayalew, additional, Teh, Bin Tean, additional, Teng, Joyce M.C., additional, Tepper, Joel E., additional, Thaker, Premal H., additional, Thrift, Aaron P., additional, Tran, Arthur-Quan, additional, Triska, Grace, additional, Trump, Donald, additional, Tsai, Kenneth, additional, Tseng, Chia-Lin, additional, Tseng, Diane, additional, Van Schaeybroeck, Sandra, additional, Van Tine, Brian A., additional, Vanness, Erin R., additional, Varadhachary, Gauri, additional, Varella-Garcia, Marileila, additional, Wahl, Richard L., additional, Walsh, Michael F., additional, Wang, Thomas, additional, Weiss, Jared, additional, Weissman, Irving L., additional, Westin, Shannon N., additional, White, Jeffrey D., additional, Wilson, Richard, additional, Wong, Richard J., additional, Wood, Gary S., additional, Xu, Yaohui G., additional, Xu-Welliver, Meng, additional, Yust-Katz, Shlomit, additional, Zagar, Timothy, additional, Zeman, Elaine M., additional, Zhang, Tian, additional, and Zwiebel, James A., additional

Published
2020
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29. Genetic Factors

Author

Walsh, Michael F., primary, Cadoo, Karen, additional, Salo-Mullen, Erin E., additional, Dubard-Gault, Marianne, additional, Stadler, Zsofia K., additional, and Offit, Kenneth, additional

Published
2020
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32. Prevalence and Characterization of Biallelic and Monoallelic NTHL1 and MSH3 Variant Carriers From a Pan-Cancer Patient Population

Author

Salo-Mullen, Erin E., Maio, Anna, Mukherjee, Semanti, Bandlamudi, Chaitanya, Shia, Jinru, Kemel, Yelena, Cadoo, Karen A., Liu, Ying, Carlo, Maria, Ranganathan, Megha, Kane, Sarah, Srinivasan, Preethi, Chavan, Shweta S., Donoghue, Mark T. A., Bourque, Caitlin, Sheehan, Margaret, Tejada, Prince Rainier, Patel, Zalak, Arnold, Angela G., Kennedy, Jennifer A., Amoroso, Kimberly, Breen, Kelsey, Catchings, Amanda, Sacca, Rosalba, Marcell, Vanessa, Markowitz, Arnold J., Latham, Alicia, Walsh, Michael, Misyura, Maksym, Ceyhan-Birsoy, Ozge, Solit, David B., Berger, Michael F., Robson, Mark E., Taylor, Barry S., Offit, Kenneth, Mandelker, Diana, and Stadler, Zsofia K.

Published
2021
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33. Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers

Author

Veeraraghavan, Harini, Friedman, Claire F., DeLair, Deborah F., Ninčević, Josip, Himoto, Yuki, Bruni, Silvio G., Cappello, Giovanni, Petkovska, Iva, Nougaret, Stephanie, Nikolovski, Ines, Zehir, Ahmet, Abu-Rustum, Nadeem R., Aghajanian, Carol, Zamarin, Dmitriy, Cadoo, Karen A., Diaz, Jr., Luis A., Leitao, Jr., Mario M., Makker, Vicky, Soslow, Robert A., Mueller, Jennifer J., Weigelt, Britta, and Lakhman, Yulia

Published
2020
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34. Pathogenic germline variants in patients with endometrial cancer of diverse ancestry.

Author

Liu, Ying L., Gordhandas, Sushmita, Arora, Kanika, Rios‐Doria, Eric, Cadoo, Karen A., Catchings, Amanda, Maio, Anna, Kemel, Yelena, Sheehan, Margaret, Salo‐Mullen, Erin, Zhou, Qin, Iasonos, Alexia, Carrot‐Zhang, Jian, Manning‐Geist, Beryl, Sia, Tiffany Y., Selenica, Pier, Vanderbilt, Chad, Misyura, Maksym, Latham, Alicia, and Bandlamudi, Chaitanya

Subjects
ENDOMETRIAL cancer, CANCER patients, GENETIC counseling, GERM cells, GENEALOGY, DNA mismatch repair
Abstract

Background: Racial disparities in outcomes exist in endometrial cancer (EC). The contribution of ancestry‐based variations in germline pathogenic variants (gPVs) is unknown. Methods: Germline assessment of ≥76 cancer predisposition genes was performed in patients with EC undergoing tumor‐normal Memorial Sloan Kettering Cancer Center Integrated Mutation Profiling of Actionable Cancer Targets sequencing from January 1, 2015 through June 30, 2021. Self‐reported race/ethnicity and Ashkenazi Jewish ancestry data classified patients into groups. Genetic ancestry was inferred from Memorial Sloan Kettering Cancer Center Integrated Mutation Profiling of Actionable Cancer Targets. Rates of gPV and genetic counseling were compared by ancestry. Results: Among 1625 patients with EC, 216 (13%) had gPVs; 15 had >1 gPV. Rates of gPV varied by self‐reported ancestry (Ashkenazi Jewish, 40/202 [20%]; Asian, 15/124 [12%]; Black/African American (AA), 12/171 [7.0%]; Hispanic, 15/124 [12%]; non‐Hispanic (NH) White, 129/927 [14%]; missing, 5/77 [6.5%]; p =.009], with similar findings by genetic ancestry (p <.001). We observed a lower likelihood of gPVs in patients of Black/AA (odds ratio [OR], 0.44; 95% CI, 0.22–0.81) and African (AFR) ancestry (OR, 0.42; 95% CI, 0.18–0.85) and a higher likelihood in patients of Ashkenazi Jewish genetic ancestry (OR, 1.62; 95% CI; 1.11–2.34) compared with patients of non‐Hispanic White/European ancestry, even after adjustment for age and molecular subtype. Somatic landscape influenced gPVs with lower rates of microsatellite instability‐high tumors in patients of Black/AA and AFR ancestry. Among those with newly identified gPVs (n = 114), 102 (89%) were seen for genetic counseling, with lowest rates among Black/AA (75%) and AFR patients (67%). Conclusions: In those with EC, gPV and genetic counseling varied by ancestry, with lowest rates among Black/AA and AFR patients, potentially contributing to disparities in outcomes given implications for treatment and cancer prevention. Plain Language Summary: Black women with endometrial cancer do worse than White women, and there are many reasons for this disparity.Certain genetic changes from birth (mutations) can increase the risk of cancer, and it is unknown if rates of these changes are different between different ancestry groups.Genetic mutations in 1625 diverse women with endometrial cancer were studied and the lowest rates of mutations and genetic counseling were found in Black and African ancestry women. This could affect their treatment options as well as their families and may make disparities worse. Among 1625 patients with endometrial cancer, 216 (13%) had germline pathogenic variants, and rates of germline pathogenic variants and subsequent genetic counseling varied by both self‐reported and inferred genetic ancestry, with lowest rates among Black/African American and African patients. These differences could potentially contribute to disparities in outcomes given implications for treatment and cancer prevention and should be further investigated. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Supplementary Data from Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non–Muscle-Invasive Bladder Cancer

Author

Pietzak, Eugene J., primary, Whiting, Karissa, primary, Srinivasan, Preethi, primary, Bandlamudi, Chaitanya, primary, Khurram, Aliya, primary, Joseph, Vijai, primary, Walasek, Aleksandra, primary, Bochner, Emily, primary, Clinton, Timothy, primary, Almassi, Nima, primary, Truong, Hong, primary, de Jesus Escano, Manuel R., primary, Wiseman, Michal, primary, Mandelker, Diana, primary, Kemel, Yelena, primary, Zhang, Liying, primary, Walsh, Michael F., primary, Cadoo, Karen A., primary, Coleman, Jonathan A., primary, Al-Ahmadie, Hikmat, primary, Rosenberg, Jonathan E., primary, Iyer, Gopakumar V., primary, Solit, David B., primary, Ostrovnaya, Irina, primary, Offit, Kenneth, primary, Robson, Mark E., primary, Stadler, Zsofia K., primary, Berger, Michael F., primary, Bajorin, Dean F., primary, Carlo, Maria, primary, and Bochner, Bernard H., primary

Published
2023
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40. Supplementary Data from Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study

Author

Moore, Kathleen N., primary, Chambers, Setsuko K., primary, Hamilton, Erika P., primary, Chen, Lee-may, primary, Oza, Amit M., primary, Ghamande, Sharad A., primary, Konecny, Gottfried E., primary, Plaxe, Steven C., primary, Spitz, Daniel L., primary, Geenen, Jill J.J., primary, Troso-Sandoval, Tiffany A., primary, Cragun, Janiel M., primary, Rodrigo Imedio, Esteban, primary, Kumar, Sanjeev, primary, Mugundu, Ganesh M., primary, Lai, Zhongwu, primary, Chmielecki, Juliann, primary, Jones, Suzanne F., primary, Spigel, David R., primary, and Cadoo, Karen A., primary

Published
2023
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41. Supplementary Table and Figure Legends from Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer

Author

Soumerai, Tara E., primary, Donoghue, Mark T.A., primary, Bandlamudi, Chaitanya, primary, Srinivasan, Preethi, primary, Chang, Matthew T., primary, Zamarin, Dmitriy, primary, Cadoo, Karen A., primary, Grisham, Rachel N., primary, O'Cearbhaill, Roisin E., primary, Tew, William P., primary, Konner, Jason A., primary, Hensley, Martee L., primary, Makker, Vicky, primary, Sabbatini, Paul, primary, Spriggs, David R., primary, Troso-Sandoval, Tiffany A., primary, Charen, Alexandra Snyder, primary, Friedman, Claire, primary, Gorsky, Mila, primary, Schweber, Sarah J., primary, Middha, Sumit, primary, Murali, Rajmohan, primary, Chiang, Sarah, primary, Park, Kay J., primary, Soslow, Robert A., primary, Ladanyi, Marc, primary, Li, Bob T., primary, Mueller, Jennifer, primary, Weigelt, Britta, primary, Zehir, Ahmet, primary, Berger, Michael F., primary, Abu-Rustum, Nadeem R., primary, Aghajanian, Carol, primary, DeLair, Deborah F., primary, Solit, David B., primary, Taylor, Barry S., primary, and Hyman, David M., primary

Published
2023
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42. Figure S1 from Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer

Author

Soumerai, Tara E., primary, Donoghue, Mark T.A., primary, Bandlamudi, Chaitanya, primary, Srinivasan, Preethi, primary, Chang, Matthew T., primary, Zamarin, Dmitriy, primary, Cadoo, Karen A., primary, Grisham, Rachel N., primary, O'Cearbhaill, Roisin E., primary, Tew, William P., primary, Konner, Jason A., primary, Hensley, Martee L., primary, Makker, Vicky, primary, Sabbatini, Paul, primary, Spriggs, David R., primary, Troso-Sandoval, Tiffany A., primary, Charen, Alexandra Snyder, primary, Friedman, Claire, primary, Gorsky, Mila, primary, Schweber, Sarah J., primary, Middha, Sumit, primary, Murali, Rajmohan, primary, Chiang, Sarah, primary, Park, Kay J., primary, Soslow, Robert A., primary, Ladanyi, Marc, primary, Li, Bob T., primary, Mueller, Jennifer, primary, Weigelt, Britta, primary, Zehir, Ahmet, primary, Berger, Michael F., primary, Abu-Rustum, Nadeem R., primary, Aghajanian, Carol, primary, DeLair, Deborah F., primary, Solit, David B., primary, Taylor, Barry S., primary, and Hyman, David M., primary

Published
2023
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43. Table S1 from Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer

Author

Soumerai, Tara E., primary, Donoghue, Mark T.A., primary, Bandlamudi, Chaitanya, primary, Srinivasan, Preethi, primary, Chang, Matthew T., primary, Zamarin, Dmitriy, primary, Cadoo, Karen A., primary, Grisham, Rachel N., primary, O'Cearbhaill, Roisin E., primary, Tew, William P., primary, Konner, Jason A., primary, Hensley, Martee L., primary, Makker, Vicky, primary, Sabbatini, Paul, primary, Spriggs, David R., primary, Troso-Sandoval, Tiffany A., primary, Charen, Alexandra Snyder, primary, Friedman, Claire, primary, Gorsky, Mila, primary, Schweber, Sarah J., primary, Middha, Sumit, primary, Murali, Rajmohan, primary, Chiang, Sarah, primary, Park, Kay J., primary, Soslow, Robert A., primary, Ladanyi, Marc, primary, Li, Bob T., primary, Mueller, Jennifer, primary, Weigelt, Britta, primary, Zehir, Ahmet, primary, Berger, Michael F., primary, Abu-Rustum, Nadeem R., primary, Aghajanian, Carol, primary, DeLair, Deborah F., primary, Solit, David B., primary, Taylor, Barry S., primary, and Hyman, David M., primary

Published
2023
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45. Understanding Inherited Risk in Unselected Newly Diagnosed Patients With Endometrial Cancer

Author

Cadoo, Karen A., Mandelker, Diana L., Mukherjee, Semanti, Stewart, Carolyn, DeLair, Deborah, Ravichandran, Vignesh, Srinivasan, Preethi, Hurley, Daire, Kemel, Yelena, Arnold, Angela G., Sheehan, Margaret, Pradhan, Nisha, Joseph, Vijai, Chi, Dennis S., Gardner, Ginger J., Jewell, Elizabeth L., Leitao, Mario M., Jr, Roche, Kara Long, Mueller, Jennifer J., Sonoda, Yukio, Zivanovic, Oliver, Walsh, Michael, Carlo, Maria I., Berger, Michael F., Hyman, David M., Zhang, Liying, Robson, Mark E., Offit, Kenneth, Aghajanian, Carol, Abu-Rustum, Nadeem R., and Stadler, Zsofia

Published
2019
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46. Comprehensive analysis of germline drivers in endometrial cancer

Author

Gordhandas, Sushmita, primary, Rios-Doria, Eric, additional, Cadoo, Karen A, additional, Catchings, Amanda, additional, Maio, Anna, additional, Kemel, Yelena, additional, Sheehan, Margaret, additional, Ranganathan, Megha, additional, Green, Dina, additional, Aryamvally, Anjali, additional, Arnold, Angela G, additional, Salo-Mullen, Erin, additional, Manning-Geist, Beryl, additional, Sia, Tiffany, additional, Selenica, Pier, additional, Da Cruz Paula, Arnaud, additional, Vanderbilt, Chad, additional, Misyura, Maksym, additional, Leitao, Mario M, additional, Mueller, Jennifer J, additional, Makker, Vicky, additional, Rubinstein, Maria, additional, Friedman, Claire F, additional, Zhou, Qin, additional, Iasonos, Alexia, additional, Latham, Alicia, additional, Carlo, Maria I, additional, Murciano-Goroff, Yonina R, additional, Will, Marie, additional, Walsh, Michael F, additional, Issa Bhaloo, Shirin, additional, Ellenson, Lora H, additional, Ceyhan-Birsoy, Ozge, additional, Berger, Michael F, additional, Robson, Mark E, additional, Abu-Rustum, Nadeem, additional, Aghajanian, Carol, additional, Offit, Kenneth, additional, Stadler, Zsofia, additional, Weigelt, Britta, additional, Mandelker, Diana L, additional, and Liu, Ying L, additional

Published
2023
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47. Durvalumab with or without tremelimumab in patients with persistent or recurrent endometrial cancer or endometrial carcinosarcoma: A randomized open-label phase 2 study

Author

Rubinstein, Maria M., primary, Doria, Eric Rios, additional, Konner, Jason, additional, Lichtman, Stuart, additional, Zhou, Qin, additional, Iasonos, Alexia, additional, Sarasohn, Debra, additional, Troso-Sandoval, Tiffany, additional, Friedman, Claire, additional, O'Cearbhaill, Roisin, additional, Cadoo, Karen, additional, Kyi, Chrisann, additional, Cohen, Seth, additional, Soldan, Krysten, additional, Billinson, Eric, additional, Caird, Imogen, additional, Jang, Dasom, additional, Eid, Khalil, additional, Shah, Pooja, additional, Guillen, Joyce, additional, Aghajanian, Carol, additional, Zamarin, Dmitriy, additional, and Makker, Vicky, additional

Published
2023
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48. EP263/#849 Olaparib treatment in patients with platinum-sensitive relapsed ovarian cancer by BRCA mutation and homologous recombination deficiency status: characterization of long-term/short-term treatment duration in light

Author

Liu, Ying, primary, Mathews, Cara, additional, Simpkins, Fiona, additional, Cadoo, Karen, additional, Provencher, Diane, additional, Mccormick, Colleen, additional, Einaggar, Adam, additional, Altman, Alon, additional, Gilbert, Lucy, additional, Black, Destin, additional, Kabil, Nashwa, additional, Taylor, Rosie, additional, Barnicle, Alan, additional, Munley, Jiefen, additional, and Aghajanian, Carol, additional

Published
2022
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49. O017/#479 Germline pathogenic variants in DNA repair genes and endometrial cancer risk

Author

Gordhandas, Sushmita, primary, Rios-Doria, Eric, additional, Cadoo, Karen, additional, Catchings, Amanda, additional, Maio, Anna, additional, Kemel, Yelena, additional, Manning-Geist, Beryl, additional, Sia, Tiffany, additional, Roche, Kara Long, additional, Leitao, Mario, additional, Mueller, Jennifer, additional, Makker, Vicky, additional, Rubinstein, Maria, additional, Friedman, Claire, additional, Ellenson, Lora, additional, Birsoy, Ozge, additional, Abu-Rustum, Nadeem, additional, Aghajanian, Carol, additional, Offit, Kenneth, additional, Stadler, Zsofia, additional, Weigelt, Britta, additional, Mandelker, Diana, additional, and Liu, Ying, additional

Published
2022
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50. Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers

Author

Ehmann, Sarah, primary, Sassine, Dib, additional, Straubhar, Alli M., additional, Praiss, Aaron M., additional, Aghajanian, Carol, additional, Alektiar, Kaled M., additional, Broach, Vance, additional, Cadoo, Karen A., additional, Jewell, Elizabeth L., additional, Boroujeni, Amir Momeni, additional, Kyi, Chrisann, additional, Leitao, Mario M., additional, Mueller, Jennifer J., additional, Murali, Rajmohan, additional, Bhaloo, Shirin Issa, additional, O'Cearbhaill, Roisin E., additional, Park, Kay J., additional, Sonoda, Yukio, additional, Weigelt, Britta, additional, Zamarin, Dmitriy, additional, Abu-Rustum, Nadeem, additional, and Friedman, Claire F., additional

Published
2022
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