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2. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Author

Chang, Chun-Pin, Chang, Shen-Chih, Chuang, Shu-Chun, Berthiller, Julien, Ferro, Gilles, Matsuo, Keitaro, Wünsch-Filho, Victor, Toporcov, Tatiana N, de Carvalho, Marcos Brasilino, La Vecchia, Carlo, Olshan, Andrew F, Zevallos, Jose P, Serraino, Diego, Muscat, Joshua, Sturgis, Erich M, Li, Guojun, Morgenstern, Hal, Levi, Fabio, Dal Maso, Luigino, Smith, Elaine, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Winn, Deborah M, Bosetti, Cristina, Edefonti, Valeria, Garavello, Werner, Negri, Eva, Hayes, Richard B, Purdue, Mark P, Boccia, Stefania, Cadoni, Gabriella, Shangina, Oxana, Koifman, Rosalina, Curado, Maria Paula, Vilensky, Marta, Swiatkowska, Beata, Herrero, Rolando, Franceschi, Silvia, Benhamou, Simone, Fernandez, Leticia, Menezes, Ana MB, Daudt, Alexander W, Mates, Dana, Schantz, Stimson, Yu, Guo-Pei, Lissowska, Jolanta, Brenner, Hermann, Fabianova, Eleonora, Rudnai, Peter, Brennan, Paul, Boffetta, Paolo, Zhang, Zuo-Feng, Hashibe, Mia, and Lee, Yuan-Chin Amy

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Services and Systems, Health Sciences, Public Health, Oncology and Carcinogenesis, Prevention, Rare Diseases, Cancer, Tobacco Smoke and Health, Dental/Oral and Craniofacial Disease, Substance Misuse, Tobacco, Aetiology, 2.2 Factors relating to the physical environment, Good Health and Well Being, Adult, Age Factors, Aged, Case-Control Studies, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Nicotiana, Age at start of tobacco use, Head and neck cancer, Oral cancer, Oropharyngeal cancer, Hypopharyngeal cancer, Laryngeal cancer, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundTobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk.MethodsWe analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models.ResultsWithout adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR

Published
2019

3. Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

Author

Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, deFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, and Ganz, Patricia A

Subjects
MD Multidisciplinary
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2019

4. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author

Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Rios, Leonardo F Boaventura, Toporcov, Tatiana N, Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F, Zevallos, Jose P, La Vecchia, Carlo, Winn, Deborah M, Sturgis, Erich M, Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, McClean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B, Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Dal Maso, Luigino

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Tobacco Smoke and Health, Substance Misuse, Tobacco, Dental/Oral and Craniofacial Disease, Rare Diseases, Cancer, 2.2 Factors relating to the physical environment, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cigarette Smoking, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Head and neck cancer, INHANCE, Laryngeal cancer, Oral cavity and pharyngeal cancers, Dentistry, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

ObjectivesThis study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.Materials and methodsWe pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.ResultsFor oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.ConclusionReferring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Published
2019

5. Shared heritability and functional enrichment across six solid cancers.

Author

Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, deFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, and Ganz, Patricia A

Subjects
Humans, Breast Neoplasms, Colorectal Neoplasms, Ovarian Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Prostatic Neoplasms, Genetic Predisposition to Disease, Neoplasm Proteins, Case-Control Studies, Smoking, Mental Disorders, Inheritance Patterns, Phenotype, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Female, Male, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Prevention, Cancer, Breast Cancer, Genetics, Rare Diseases, Lung Cancer, Human Genome, Colo-Rectal Cancer, Digestive Diseases, Lung, MD Multidisciplinary
Abstract

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

Published
2019

6. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

Author

Lesseur, Corina, Diergaarde, Brenda, Olshan, Andrew F, Wünsch-Filho, Victor, Ness, Andrew R, Liu, Geoffrey, Lacko, Martin, Eluf-Neto, José, Franceschi, Silvia, Lagiou, Pagona, Macfarlane, Gary J, Richiardi, Lorenzo, Boccia, Stefania, Polesel, Jerry, Kjaerheim, Kristina, Zaridze, David, Johansson, Mattias, Menezes, Ana M, Curado, Maria Paula, Robinson, Max, Ahrens, Wolfgang, Canova, Cristina, Znaor, Ariana, Castellsagué, Xavier, Conway, David I, Holcátová, Ivana, Mates, Dana, Vilensky, Marta, Healy, Claire M, Szeszenia-Dąbrowska, Neonila, Fabiánová, Eleonóra, Lissowska, Jolanta, Grandis, Jennifer R, Weissler, Mark C, Tajara, Eloiza H, Nunes, Fabio D, de Carvalho, Marcos B, Thomas, Steve, Hung, Rayjean J, Peters, Wilbert HM, Herrero, Rolando, Cadoni, Gabriella, Bueno-de-Mesquita, H Bas, Steffen, Annika, Agudo, Antonio, Shangina, Oxana, Xiao, Xiangjun, Gaborieau, Valérie, Chabrier, Amélie, Anantharaman, Devasena, Boffetta, Paolo, Amos, Christopher I, McKay, James D, and Brennan, Paul

Subjects
Biological Sciences, Genetics, Cancer, Clinical Research, Dental/Oral and Craniofacial Disease, Digestive Diseases, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Aged, Case-Control Studies, Female, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, HLA Antigens, Haplotypes, Humans, Male, Middle Aged, Mouth, Mouth Neoplasms, Papillomaviridae, Papillomavirus Infections, Pharyngeal Neoplasms, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10-8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10-9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10-6) than in HPV-negative (OR = 0.75, P = 0.16) cancers.

Published
2016

7. Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium

Author

Sassano, M., Taborelli, M., Boccia, Stefania, Cadoni, Gabriella, La Vecchia, C., Garavello, W., Lazarus, P., Lee, Y. C. A., Hashibe, M., Boffetta, Paolo, Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Boffetta P., Sassano, M., Taborelli, M., Boccia, Stefania, Cadoni, Gabriella, La Vecchia, C., Garavello, W., Lazarus, P., Lee, Y. C. A., Hashibe, M., Boffetta, Paolo, Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), and Boffetta P.

Abstract

Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium.Methods: Four case-control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian-Laird random-effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials.Results: Aspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer.Conclusions: This study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.

Published
2024

9. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Author

Berthiller, Julien, Straif, Kurt, Agudo, Antonio, Ahrens, Wolfgang, dos Santos, Alexandre Bezerra, Boccia, Stefania, Cadoni, Gabriella, Canova, Cristina, Castellsague, Xavier, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Fukuyama, Erica E, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, Lagiou, Pagona, La Vecchia, Carlo, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Macfarlane, Tatiana, Mates, Dana, McClean, Michael, Menezes, Ana, Merletti, Franco, Morgenstern, Hal, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark, Ramroth, Heribert, Rudnai, Peter, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Szeszenia-Dabrowska, Neonila, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Wei, Qingyi, Winn, Deborah M, Wünsch-Filho, Victor, Zhang, Zuo-Feng, Znaor, Ariana, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, Hashibe, Mia, and Lee, Yuan-Chin Amy

Subjects
Cancer, Prevention, Dental/Oral and Craniofacial Disease, Tobacco Smoke and Health, Substance Misuse, Clinical Research, Rare Diseases, Tobacco, Respiratory, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Case-Control Studies, Cigarette Smoking, Female, Head and Neck Neoplasms, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Public Health, Risk Factors, Head and neck cancer, low frequency cigarette smoking, risk factors, pooled analysis, Statistics, Public Health and Health Services, Epidemiology
Abstract

BackgroundCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (0-3, >3-5, >5-10 cigarettes per day.ResultsSmoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.ConclusionOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.

Published
2016

10. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Leoncini, Emanuele, Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Cadoni, Gabriella, Ferraroni, Monica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Lee, Yuan-Chin Amy, Chuang, Shu-Chun, Decarli, Adriano, La Vecchia, Carlo, and Boccia, Stefania

Subjects
Public Health, Health Sciences, Dental/Oral and Craniofacial Disease, Nutrition, Digestive Diseases, Prevention, Rare Diseases, Cancer, Oral and gastrointestinal, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Antioxidants, Carcinoma, Squamous Cell, Carotenoids, Case-Control Studies, Epidemiologic Studies, Europe, Female, Head and Neck Neoplasms, Humans, Japan, Middle Aged, Squamous Cell Carcinoma of Head and Neck, United States, Head and neck cancer, Nutrients, Diet, Public Health and Health Services, Epidemiology
Abstract

Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p

Published
2016

11. Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer

Author

Ferreiro-Iglesias, Aida, McKay, James D., Brenner, Nicole, Virani, Shama, Lesseur, Corina, Gaborieau, Valerie, Ness, Andy R., Hung, Rayjean J., Liu, Geoffrey, Diergaarde, Brenda, Olshan, Andrew F., Hayes, Neil, Weissler, Mark C., Schroeder, Lea, Bender, Noemi, Pawlita, Michael, Thomas, Steve, Pring, Miranda, Dudding, Tom, Kanterewicz, Beatriz, Ferris, Robert, Thomas, Sera, Brhane, Yonathan, Díez-Obrero, Virginia, Milojevic, Maja, Smith-Byrne, Karl, Mariosa, Daniela, Johansson, Mattias J., Herrero, Rolando, Boccia, Stefania, Cadoni, Gabriella, Lacko, Martin, Holcátová, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Lagiou, Areti, Polesel, Jerry, Simonato, Lorenzo, Merletti, Franco, Healy, Claire M., Hansen, Bo T., Nygård, Mari, Conway, David I., Wright, Sylvia, Macfarlane, Tatiana V., Robinson, Max, Alemany, Laia, Agudo, Antonio, Znaor, Ariana, Amos, Christopher I., Waterboer, Tim, and Brennan, Paul

Published
2021
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12. Hearing Impairment and Neuroimaging Results in Mitochondrial Diseases

Author

Cadoni, Gabriella, Primiano, Guido Alessandro, Picciotti, Pasqualina Maria, Calandrelli, Rosalinda, Galli, Jacopo, Servidei, Serenella, Conti, Guido, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Primiano, Guido, Picciotti, Pasqualina M (ORCID:0000-0002-1502-6508), Galli, Jacopo (ORCID:0000-0001-6353-6249), Servidei, Serenella (ORCID:0000-0001-8478-2799), Conti, Guido (ORCID:0000-0003-2565-4206), Cadoni, Gabriella, Primiano, Guido Alessandro, Picciotti, Pasqualina Maria, Calandrelli, Rosalinda, Galli, Jacopo, Servidei, Serenella, Conti, Guido, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Primiano, Guido, Picciotti, Pasqualina M (ORCID:0000-0002-1502-6508), Galli, Jacopo (ORCID:0000-0001-6353-6249), Servidei, Serenella (ORCID:0000-0001-8478-2799), and Conti, Guido (ORCID:0000-0003-2565-4206)

Abstract

Mitochondrial diseases (MDs) are heterogeneous genetic disorders characterized by mitochondrial DNA (mtDNA) defects, involving tissues highly dependent on oxidative metabolism: the inner ear, brain, eye, skeletal muscle, and heart. We describe adult patients with genetically defined MDs, characterizing hearing function and neuroimaging results. We enrolled 34 patients (mean age: 50.02 +/- 15 years, range: 18-75 years; 20 females and 14 males) classified in four groups: MELAS, MIDD, PEO, and Encephalopathy/Polyneuropathy. Audiological evaluations included psychoacoustical tests (pure-tone and speech audiometry), electrophysiological tests (Auditory Brainstem Responses, ABRs), and Impedenzometry. Neuroimaging evaluations considered global MRI abnormalities or structural brain changes. In total, 19/34 patients carried the m.3243A > G mutation (6 affected by MELAS, 12 affected by MIDD, and 1 affected by PEO); 11 had an mtDNA deletion (all affected by PEO); 3 had nuclear genes associated with MDs (POLG1 and OPA1); and 1 patient had an mtDNA deletion without an identified nuclear gene defect (affected by PEO). Sensory neural, bilateral, and symmetrical hearing loss was present in 25 patients (73.5%) to different degrees: 9 mild, 9 moderate, 5 severe, and 2 profound. The severe/profound and mild hearing losses were associated with pantonal and high-frequency audiograms, respectively. Instead, moderate hearing losses were associated with both high-frequency (five cases) and pantonal (five cases) audiogram shapes. In addition, 21/25 patients showed a cochlear site of lesion (84%), and 4/25 (16%) showed a retrocochlear site. We found global MRI abnormalities or structural brain changes in 26/30 subjects (86.6%): 21 had white matter abnormalities, 15 had cortical atrophy, 10 had subcortical atrophy, 8 had basal nuclei involvement or cerebellar atrophy, 4 had stroke-like lesions or laminar necrosis, and 1 had cysts or vacuolated lesions. We concluded that genetic alterations

Published
2023

13. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Author

Toporcov, Tatiana Natasha, Znaor, Ariana, Zhang, Zuo-Feng, Yu, Guo-Pei, Winn, Deborah M, Wei, Qingyi, Vilensky, Marta, Vaughan, Thomas, Thomson, Peter, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M, Smith, Elaine, Shangina, Oxana, Schwartz, Stephen M, Schantz, Stimson, Rudnai, Peter, Richiardi, Lorenzo, Ramroth, Heribert, Purdue, Mark P, Olshan, Andrew F, Eluf-Neto, José, Muscat, Joshua, Moyses, Raquel Ajub, Morgenstern, Hal, Menezes, Ana, McClean, Michael, Matsuo, Keitaro, Mates, Dana, Macfarlane, Tatiana V, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Lagiou, Pagona, Koifman, Sergio, Kjaerheim, Kristina, Kelsey, Karl, Holcatova, Ivana, Herrero, Rolando, Healy, Claire, Hayes, Richard B, Franceschi, Silvia, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W, Curioni, Otávio Alberto, Maso, Luigino Dal, Curado, Maria Paula, Conway, David I, Chen, Chu, Castellsague, Xavier, Canova, Cristina, Cadoni, Gabriella, Brennan, Paul, Boccia, Stefania, Antunes, José Leopoldo Ferreira, Ahrens, Wolfgang, Agudo, Antonio, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Filho, Victor Wünsch

Subjects
Prevention, Cancer, Clinical Research, Tobacco, Tobacco Smoke and Health, Dental/Oral and Craniofacial Disease, Rare Diseases, Digestive Diseases, Aging, Good Health and Well Being, Adult, Age Factors, Alcohol Drinking, Case-Control Studies, Female, Genetic Predisposition to Disease, Head and Neck Neoplasms, Humans, Incidence, Male, Middle Aged, Odds Ratio, Registries, Risk Factors, Sex Factors, Smoking, Head and neck neoplasms, adult, smoking, alcohol drinking, diet, Statistics, Public Health and Health Services, Epidemiology
Abstract

BackgroundIncreasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.MethodsWe pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults.ConclusionsDifferences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

Published
2015

14. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, Paul, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Talamini, Renato, La Vecchia, Carlo, Olshan, Andrew F, Winn, Deborah M, Herrero, Rolando, Franceschi, Silvia, Castellsague, Xavier, Muscat, Joshua, Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Dal Maso, Luigino, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Purdue, Mark P, Hayes, Richard B, Chen, Chu, Schwartz, Stephen M, Shangina, Oxana, Koifman, Sergio, Ahrens, Wolfgang, Matos, Elena, Lagiou, Pagona, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Fernandez, Leticia, Menezes, Ana, Agudo, Antonio, Daudt, Alexander W, Richiardi, Lorenzo, Kjaerheim, Kristina, Mates, Dana, Betka, Jaroslav, Yu, Guo-Pei, Schantz, Stimson, Simonato, Lorenzo, Brenner, Hermann, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Fabianova, Eleonora, Znaor, Ariana, Rudnai, Peter, Healy, Claire, Boffetta, Paolo, Chuang, Shu-Chun, Lee, Yuan-Chin Amy, Hashibe, Mia, and Boccia, Stefania

Subjects
Tobacco Smoke and Health, Clinical Research, Prevention, Tobacco, Cancer, Rare Diseases, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Body Height, Case-Control Studies, Educational Status, Female, Head and Neck Neoplasms, Humans, Incidence, Interviews as Topic, Logistic Models, Male, Middle Aged, Odds Ratio, Overweight, Risk Factors, Smoking, Height, Consortium, Head and neck neoplasms, Public Health and Health Services, Epidemiology
Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95% CI 0.86-0.95 for men; adjusted OR = 0.86, 95% CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Published
2014

16. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

Author

Leoncini, Emanuele, Vukovic, Vladimir, Cadoni, Gabriella, Giraldi, Luca, Pastorino, Roberta, Arzani, Dario, Petrelli, Livia, Wünsch-Filho, Victor, Toporcov, Tatiana Natasha, Moyses, Raquel Ayub, Matsuo, Keitaro, Bosetti, Cristina, La Vecchia, Carlo, Serraino, Diego, Simonato, Lorenzo, Merletti, Franco, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Boccia, Stefania

Published
2018
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17. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Author

Chuang, Shu-Chun, Jenab, Mazda, Heck, Julia E, Bosetti, Cristina, Talamini, Renato, Matsuo, Keitaro, Castellsague, Xavier, Franceschi, Silvia, Herrero, Rolando, Winn, Deborah M, Vecchia, Carlo La, Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Maso, Luigino Dal, Kelsey, Karl, McClean, Michael D, Vaughan, Thomas, Lazarus, Philip, Muscat, Joshua, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Eluf-Neto, Jose, Hayes, Richard B, Purdue, Mark, Boccia, Stefania, Cadoni, Gabriella, Zaridze, David, Koifman, Sergio, Curado, Maria Paula, Ahrens, Wolfgang, Benhamou, Simone, Matos, Elena, Lagiou, Pagona, Szeszenia-Dabrowska, Neonilla, Olshan, Andrew F, Fernandez, Leticia, Menezes, Ana, Agudo, Antonio, Daudt, Alexander W, Merletti, Franco, Macfarlane, Gary J, Kjaerheim, Kristina, Mates, Dana, Holcatova, Ivana, Schantz, Stimson, Yu, Guo-Pei, Simonato, Lorenzo, Brenner, Hermann, Mueller, Heiko, Conway, David I, Thomson, Peter, Fabianova, Eleonora, Znaor, Ariana, Rudnai, Peter, Healy, Claire M, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, and Hashibe, Mia

Subjects
Nutrition, Cancer, Prevention, Clinical Research, Dental/Oral and Craniofacial Disease, Adult, Aged, Case-Control Studies, Diet, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Head and neck cancer, Fruit and vegetable, Red meat, Processed meat, Oncology and Carcinogenesis, Public Health and Health Services, Epidemiology
Abstract

We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).

Published
2012

19. Supplementary Table from Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium

Author

Pastorino, Roberta, primary, Sassano, Michele, primary, Danilo Tiziano, Francesco, primary, Giraldi, Luca, primary, Amore, Rosarita, primary, Arzani, Dario, primary, Abiusi, Emanuela, primary, Ahrens, Wolfgang, primary, Vilches, Laia Alemany, primary, Canova, Cristina, primary, Healy, Claire Mary, primary, Holcatova, Ivana, primary, Lagiou, Pagona, primary, Polesel, Jerry, primary, Popovic, Maja, primary, Nygård, Ståle, primary, Cadoni, Gabriella, primary, Znaor, Ariana, primary, Boffetta, Paolo, primary, Matsuo, Keitaro, primary, Oze, Isao, primary, Brennan, Paul, primary, and Boccia, Stefania, primary

Published
2023
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20. Data from Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium

Author

Pastorino, Roberta, primary, Sassano, Michele, primary, Danilo Tiziano, Francesco, primary, Giraldi, Luca, primary, Amore, Rosarita, primary, Arzani, Dario, primary, Abiusi, Emanuela, primary, Ahrens, Wolfgang, primary, Vilches, Laia Alemany, primary, Canova, Cristina, primary, Healy, Claire Mary, primary, Holcatova, Ivana, primary, Lagiou, Pagona, primary, Polesel, Jerry, primary, Popovic, Maja, primary, Nygård, Ståle, primary, Cadoni, Gabriella, primary, Znaor, Ariana, primary, Boffetta, Paolo, primary, Matsuo, Keitaro, primary, Oze, Isao, primary, Brennan, Paul, primary, and Boccia, Stefania, primary

Published
2023
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21. Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents

Author

D’Souza, Gypsyamber, Anantharaman, Devasena, Gheit, Tarik, Abedi-Ardekani, Behnoush, Beachler, Daniel C., Conway, David I., Olshan, Andrew F., Wunsch-Filho, Victor, Toporcov, Tatiana N., Ahrens, Wolfgang, Wisniewski, Kathy, Merletti, Franco, Boccia, Stefania, Tajara, Eloiza H., Zevallos, Jose P., Levi, José Eduardo, Weissler, Mark C., Wright, Sylvia, Scelo, Ghislaine, Mazul, Angela L, Tommasino, Massimo, Cadoni, Gabriella, and Brennan, Paul

Published
2016
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22. New onset of Susac syndrome after mRNA COVID-19 vaccine: a case report

Author

Bianco, Assunta, Colò, Francesca, Falso, Silvia, Russo, Rosellina, Carlà, Matteo Maria, Minucci, Angelo, Cadoni, Gabriella, Lucchini, Matteo, Cicia, Alessandra, Calabresi, Paolo, Mirabella, Massimiliano, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Lucchini, Matteo (ORCID:0000-0002-0447-2297), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Bianco, Assunta, Colò, Francesca, Falso, Silvia, Russo, Rosellina, Carlà, Matteo Maria, Minucci, Angelo, Cadoni, Gabriella, Lucchini, Matteo, Cicia, Alessandra, Calabresi, Paolo, Mirabella, Massimiliano, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Lucchini, Matteo (ORCID:0000-0002-0447-2297), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Mirabella, Massimiliano (ORCID:0000-0002-7783-114X)

Abstract

Susac syndrome (SuS) is a rare immune-mediated disorder, affecting microvessels in the brain, retina and inner ear, leading to central nervous system dysfunction, visual disturbances and sensorineural hearing loss. These events may occur simultaneously or in succession. Since its first description in 1979 by John Susac, about 400 cases have been described; however, SuS is probably underdiagnosed. SuS usually affects young adults between 20 and 40 years (female-to-male ratio of 3.5/1) [1, 2]. Occlusive microvascular endotheliopathy/basement membranopathy represents a disease hallmark, but the pathogenesis is still debated. Infections, diet or medications have been described as possible triggers of autoimmunity [1]. In 2006, a case of SuS after smallpox vaccination was reported. The COVID-19 pandemic has affected over 260 million people and different neurological disorders have been related to both Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccination [3]. Six cases of SuS related to SARS-CoV-2 infection or vaccination have been described: two following SARS-CoV2 infection, one related to ChAdOx1 vaccine, and three after Coronavac vaccine [4]. Here we report the first case of SuS after BNT162b2 mRNA COVID-19 vaccine (Comirnaty®).

Published
2022

23. Posturographic Analysis in Patients Affected by Central and Peripheral Visual Impairment

Author

Cadoni, Gabriella, Picciotti, Pasqualina Maria, Rolesi, Rolando, Sulfaro, Marco, Guidobaldi, Margherita, Amore, Filippo, Conti, Guido, Paludetti, Gaetano, Turco, Simona, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Picciotti, Pasqualina Maria (ORCID:0000-0002-1502-6508), Conti, Guido (ORCID:0000-0003-2565-4206), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Cadoni, Gabriella, Picciotti, Pasqualina Maria, Rolesi, Rolando, Sulfaro, Marco, Guidobaldi, Margherita, Amore, Filippo, Conti, Guido, Paludetti, Gaetano, Turco, Simona, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Picciotti, Pasqualina Maria (ORCID:0000-0002-1502-6508), Conti, Guido (ORCID:0000-0003-2565-4206), and Paludetti, Gaetano (ORCID:0000-0003-2480-1243)

Abstract

Although vision loss is known to affect equilibrium maintenance, postural control in patients affected by low vision has been poorly investigated. We evaluated postural stability and the ability to use visual, proprioceptive and vestibular information in different low vision patterns. Ten adults with normal vision (NC), fourteen adults affected by central visual impairment (CLV) and eight adults affected by peripheral visual impairment (PLV) were enrolled in our study. Patients underwent visual, vestibular and postural evaluation (bedside examination, Computed Dynamic Posturograophy). Motor Control Tests were performed to analyze automatic postural adaptive re- sponses elicited by unexpected postural disturbances. Clinical evaluations did not show abnormality in all patients. In the Sensory Organization Test, CLV and PLV patients performed more poorly in conditions 3–6 and 3–4, as compared to NC subjects. The condition 5 score was significantly lower in the CLV group with respect to the PLV patients. Composite equilibrium scores demonstrated significant differences between low-vision subjects vs. NC subjects. No differences were found for somatosensorial contribution. Visual afferences showed lower values in all visually impaired subjects, while vestibular contribution was lower in the CLV patients as compared to the NC and PLV patients. MCT latencies were significantly worse in the CLV subjects. In the low-vision patients, postural control was modified with a specific pattern of strategy adaptation. Different modulations of postural control and different adaptive responses seemed to characterize CLV patients as compared to PLV subjects.

Published
2022

24. Plasma miR-151-3p as a candidate diagnostic biomarker for head and neck cancer: a cross-sectional study within the INHANCE consortium

Author

Pastorino, Roberta, Sassano, Michele, Tiziano, Danilo Francesco, Giraldi, Luca, Amore, Rosarita, Arzani, Dario, Abiusi, Emanuela, Ahrens, Wolfgang, Alemany Vilches, Laia, Canova, Cristina, Healy, Claire Mary, Holcatova, Ivana, Lagiou, Pagona, Polesel, Jerry, Popovic, Maja, Nygård, Ståle, Cadoni, Gabriella, Znaor, Ariana, Boffetta, Paolo, Matsuo, Keitaro, Oze, Isao, Brennan, Paul, Boccia, Stefania, Pastorino, Roberta (ORCID:0000-0001-5013-0733), Tiziano, Danilo Francesco (ORCID:0000-0002-5545-6158), Abiusi, Emanuela (ORCID:0000-0001-9028-012X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Pastorino, Roberta, Sassano, Michele, Tiziano, Danilo Francesco, Giraldi, Luca, Amore, Rosarita, Arzani, Dario, Abiusi, Emanuela, Ahrens, Wolfgang, Alemany Vilches, Laia, Canova, Cristina, Healy, Claire Mary, Holcatova, Ivana, Lagiou, Pagona, Polesel, Jerry, Popovic, Maja, Nygård, Ståle, Cadoni, Gabriella, Znaor, Ariana, Boffetta, Paolo, Matsuo, Keitaro, Oze, Isao, Brennan, Paul, Boccia, Stefania, Pastorino, Roberta (ORCID:0000-0001-5013-0733), Tiziano, Danilo Francesco (ORCID:0000-0002-5545-6158), Abiusi, Emanuela (ORCID:0000-0001-9028-012X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

Identification of screening tests for the detection of head and neck cancer at an early stage is an important strategy to improving prognosis. Our objective was to identify plasma circulating microRNAs for the diagnosis of head and neck cancer (oral and laryngeal subsites), within a multicenter International Head and Neck Cancer Epidemiology (INHANCE) consortium.

Published
2022

25. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE Consortium

Author

Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)

Abstract

Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking-and alcohol with head and neck cancer.

Published
2022

26. The effect of body mass index at cancer diagnosis on survival of patients with squamous cell head and neck carcinoma

Author

Pastorino, Roberta, primary, Marafon, Denise Pires, additional, Hoxhaj, Ilda, additional, Grossi, Adriano, additional, Giraldi, Luca, additional, Rondinò, Antonella, additional, Cadoni, Gabriella, additional, Polesel, Jerry, additional, Serraino, Diego, additional, Vecchia, Carlo La, additional, Garavello, Werner, additional, Canova, Cristina, additional, Richiardi, Lorenzo, additional, Lissowska, Jolanta, additional, Pandics, Tamas, additional, Dudding, Tom, additional, Ness, Andy, additional, Thomas, Steve, additional, Pring, Miranda, additional, Kelsey, Karl, additional, McClean, Michael, additional, Bradshaw, Patrick T., additional, Zhang, Zuo-Feng, additional, Morgenstern, Hal, additional, Rozek, Laura, additional, Wolf, Gregory T., additional, Olshan, Andrew F., additional, Liu, Geoffrey, additional, Hung, Rayjean J., additional, Vilensky, Marta, additional, de Carvalho, Marcos Brasilino, additional, Lopez, Rossana Veronica Mendonza, additional, Wunsch-Filho, Victor, additional, Boffetta, Paolo, additional, Hashibe, Mia, additional, Lee, Yuan-Chin Amy, additional, and Boccia, Stefania, additional

Published
2023
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27. Therapeutic Strategies to Prevent the Recurrence of Nasal Polyps after Surgical Treatment: An Update and In Vitro Study on Growth Inhibition of Fibroblasts

Author

Rizzi, Angela, primary, Gammeri, Luca, additional, Cordiano, Raffaele, additional, Valentini, Mariagrazia, additional, Centrone, Michele, additional, Marrone, Sabino, additional, Inchingolo, Riccardo, additional, Lohmeyer, Franziska Michaela, additional, Cavaliere, Carlo, additional, Ria, Francesco, additional, Cadoni, Gabriella, additional, Gangemi, Sebastiano, additional, and Nucera, Eleonora, additional

Published
2023
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28. New onset of Susac syndrome after mRNA COVID-19 vaccine: a case report

Author

Bianco, A., Colo, F., Falso, Silvia, Russo, R., Carla', Matteo Mario, Minucci, Angelo, Cadoni, Gabriella, Lucchini, Matteo, Cicia, Alessandra, Calabresi, Paolo, Mirabella, Massimiliano, Falso S., Carla M. M., Minucci A., Cadoni G. (ORCID:0000-0001-8244-784X), Lucchini M. (ORCID:0000-0002-0447-2297), Cicia A., Calabresi P. (ORCID:0000-0003-0326-5509), Mirabella M. (ORCID:0000-0002-7783-114X), Bianco, A., Colo, F., Falso, Silvia, Russo, R., Carla', Matteo Mario, Minucci, Angelo, Cadoni, Gabriella, Lucchini, Matteo, Cicia, Alessandra, Calabresi, Paolo, Mirabella, Massimiliano, Falso S., Carla M. M., Minucci A., Cadoni G. (ORCID:0000-0001-8244-784X), Lucchini M. (ORCID:0000-0002-0447-2297), Cicia A., Calabresi P. (ORCID:0000-0003-0326-5509), and Mirabella M. (ORCID:0000-0002-7783-114X)

Abstract

inglese

Published
2023

29. Therapeutic Strategies to Prevent the Recurrence of Nasal Polyps after Surgical Treatment: An Update and In Vitro Study on Growth Inhibition of Fibroblasts

Author

Rizzi, Angela, Gammeri, L., Cordiano, R., Valentini, Mariagrazia, Centrone, M., Marrone, S., Inchingolo, Riccardo, Lohmeyer, F. M., Cavaliere, C., Ria, Francesco, Cadoni, Gabriella, Gangemi, S., Nucera, Eleonora, Rizzi A. (ORCID:0000-0002-6795-746X), Valentini M., Inchingolo R. (ORCID:0000-0003-2843-9966), Ria F. (ORCID:0000-0002-8444-0307), Cadoni G. (ORCID:0000-0001-8244-784X), Nucera E. (ORCID:0000-0002-0565-7680), Rizzi, Angela, Gammeri, L., Cordiano, R., Valentini, Mariagrazia, Centrone, M., Marrone, S., Inchingolo, Riccardo, Lohmeyer, F. M., Cavaliere, C., Ria, Francesco, Cadoni, Gabriella, Gangemi, S., Nucera, Eleonora, Rizzi A. (ORCID:0000-0002-6795-746X), Valentini M., Inchingolo R. (ORCID:0000-0003-2843-9966), Ria F. (ORCID:0000-0002-8444-0307), Cadoni G. (ORCID:0000-0001-8244-784X), and Nucera E. (ORCID:0000-0002-0565-7680)

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. We performed a literature review regarding the therapeutic strategies used to prevent nasal polyp recurrence after surgical treatment. Finally, we report an in vitro study evaluating the efficacy of lysine-acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (ketoprofen and diclofenac) on the proliferation of fibroblasts, obtained from nasal polyp tissue samples. Our study demonstrates that diclofenac, even more so than lysine-acetylsalicylic acid, significantly inhibits fibroblast proliferation and could be considered a valid therapeutic strategy in preventing CRSwNP recurrence.

Published
2023

30. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Author

Goyal, N., Hennessy, M., Lehman, E., Lin, W., Agudo, A., Ahrens, W., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Conway, D., Curado, M., Dal Maso, L., Daudt, A. W., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kanda, J. L., Kelsey, K., Hansen, B., Koifman, R., Lagiou, Pagona, La Vecchia, C., Levi, F., Li, G., Lissowska, J., Mendoza Lopez, R., Luce, D., Macfarlane, G., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moysich, K., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Muscat, J. E., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., Negri E., Boffetta P., Goyal, N., Hennessy, M., Lehman, E., Lin, W., Agudo, A., Ahrens, W., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Conway, D., Curado, M., Dal Maso, L., Daudt, A. W., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kanda, J. L., Kelsey, K., Hansen, B., Koifman, R., Lagiou, Pagona, La Vecchia, C., Levi, F., Li, G., Lissowska, J., Mendoza Lopez, R., Luce, D., Macfarlane, G., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moysich, K., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Muscat, J. E., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., Negri E., and Boffetta P.

Abstract

Objective We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and Methods The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer.

Published
2023

33. New onset of Susac syndrome after mRNA COVID-19 vaccine: a case report

Author

Bianco, Assunta, primary, Colò, Francesca, additional, Falso, Silvia, additional, Russo, Rosellina, additional, Carlà, Matteo Maria, additional, Minucci, Angelo, additional, Cadoni, Gabriella, additional, Lucchini, Matteo, additional, Cicia, Alessandra, additional, Calabresi, Paolo, additional, and Mirabella, Massimiliano, additional

Published
2022
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34. Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium

Author

Pastorino, Roberta, primary, Sassano, Michele, additional, Danilo Tiziano, Francesco, additional, Giraldi, Luca, additional, Amore, Rosarita, additional, Arzani, Dario, additional, Abiusi, Emanuela, additional, Ahrens, Wolfgang, additional, Vilches, Laia Alemany, additional, Canova, Cristina, additional, Healy, Claire Mary, additional, Holcatova, Ivana, additional, Lagiou, Pagona, additional, Polesel, Jerry, additional, Popovic, Maja, additional, Nygård, Ståle, additional, Cadoni, Gabriella, additional, Znaor, Ariana, additional, Boffetta, Paolo, additional, Matsuo, Keitaro, additional, Oze, Isao, additional, Brennan, Paul, additional, and Boccia, Stefania, additional

Published
2022
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35. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium.

Author

Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, and Franceschi, Silvia

Subjects
DEVELOPED countries, CONFIDENCE intervals, MOUTH tumors, AGE distribution, HEAD & neck cancer, LARYNGEAL tumors, OROPHARYNGEAL cancer, RISK assessment, SEX distribution, ALCOHOL drinking, RESEARCH funding, SOCIAL classes, DESCRIPTIVE statistics, DISEASE prevalence, SMOKING, ODDS ratio, LOGISTIC regression analysis, STATISTICAL models, DATA analysis software, HYPOPHARYNGEAL cancer, DISEASE risk factors
Abstract

Objective: We analyzed the pooled case‐control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and Methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Mometasone Furoate in Non-Allergic Rhinitis: A Real-Life Italian Study

Author

Rizzi, Angela, primary, Parrinello, Giuseppe, additional, De Corso, Eugenio, additional, Tricarico, Laura, additional, Centrone, Michele, additional, Di Rienzo, Alessia, additional, Laface, Chiara, additional, Passali, Giulio Cesare, additional, Cadoni, Gabriella, additional, Inchingolo, Riccardo, additional, Paludetti, Gaetano, additional, Galli, Jacopo, additional, and Nucera, Eleonora, additional

Published
2022
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37. Mometasone Furoate in Non-Allergic Rhinitis: A Real-Life Italian Study

Author

Rizzi, Angela, Parrinello, Giuseppe, De Corso, Eugenio, Tricarico, Laura, Centrone, M., Di Rienzo, A., Laface, Chiara, Passali, Giulio Cesare, Cadoni, Gabriella, Inchingolo, Riccardo, Paludetti, Gaetano, Galli, Jacopo, Nucera, Eleonora, Rizzi A. (ORCID:0000-0002-6795-746X), Parrinello G., De Corso E., Tricarico L., Laface C., Passali G. C. (ORCID:0000-0002-8176-0962), Cadoni G. (ORCID:0000-0001-8244-784X), Inchingolo R., Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Nucera E. (ORCID:0000-0002-0565-7680), Rizzi, Angela, Parrinello, Giuseppe, De Corso, Eugenio, Tricarico, Laura, Centrone, M., Di Rienzo, A., Laface, Chiara, Passali, Giulio Cesare, Cadoni, Gabriella, Inchingolo, Riccardo, Paludetti, Gaetano, Galli, Jacopo, Nucera, Eleonora, Rizzi A. (ORCID:0000-0002-6795-746X), Parrinello G., De Corso E., Tricarico L., Laface C., Passali G. C. (ORCID:0000-0002-8176-0962), Cadoni G. (ORCID:0000-0001-8244-784X), Inchingolo R., Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), and Nucera E. (ORCID:0000-0002-0565-7680)

Abstract

Background: In order to evaluate the efficacy of intranasal mometasone furoate in patients with non-allergic rhinitis (NAR), a real-life, observational, prospective study is performed. Methods: Thirty-one patients (age 18-64 years) receive intranasal (mometasone furoate, 200 mu g b.i.d. for 15 consecutive days per month for 6 consecutive months), plus isotonic nasal saline. The cytologic pattern of local inflammation, nasal airflow, through peak nasal inspiratory flow (PNIF), quality of life (QoL), through the rhinitis quality of life questionnaire (RQLQ), the sinonasal outcome test (SNOT-22), the short-form 36-item health survey (SF-36v2), and the combined symptom medication score (CSMS), and, finally, olfactory function, through Sniffin' sticks-16 identification test (SSIT-16), are evaluated at baseline and after treatment. Results: NARNE is the most frequent cytological pattern (48% of the total sample). The therapeutic response shows improvement in olfactory function and QoL. Conclusions: The results of this study confirm that intranasal mometasone furoate is an effective treatment for patients with NAR.

Published
2022

38. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer

Author

Anantharaman, Devasena, AbediArdekani, Behnoush, Beachler, Daniel C., Gheit, Tarik, Olshan, Andrew F., Wisniewski, Kathy, WunschFilho, Victor, Toporcov, Tatiana N., Tajara, Eloiza H., Levi, José Eduardo, Moyses, Raquel A., Boccia, Stefania, Cadoni, Gabriella, Rindi, Guido, Ahrens, Wolfgang, Merletti, Franco, Conway, David I., Wright, Sylvia, Carreira, Christine, Renard, Helene, Chopard, Priscilia, McKayChopin, Sandrine, Scelo, Ghislaine, Tommasino, Massimo, Brennan, Paul, and DʼSouza, Gypsyamber

Published
2017
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39. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Author

Goyal, Neerav, primary, Hennessy, Max, additional, Lehman, Erik, additional, Lin, Wenxue, additional, Agudo, Antonio, additional, Ahrens, Wolfgang, additional, Boccia, Stefania, additional, Brennan, Paul, additional, Brenner, Hermann, additional, Cadoni, Gabriella, additional, Canova, Cristina, additional, Chen, Chu, additional, Conway, David, additional, Curado, Maria Paula, additional, Dal Maso, Luigino, additional, Daudt, Alexander W., additional, Edefonti, Valeria, additional, Fabianova, Eleonora, additional, Fernandez, Leticia, additional, Franceschi, Silvia, additional, Garavello, Werner, additional, Gillison, Maura, additional, Hayes, Richard B., additional, Healy, Claire, additional, Herrero, Rolando, additional, Holcatova, Ivana, additional, Kanda, Jossy L., additional, Kelsey, Karl, additional, Hansen, Bo T., additional, Koifman, Rosalina, additional, Lagiou, Pagona, additional, La Vecchia, Carlo, additional, Levi, Fabio, additional, Li, Guojun, additional, Lissowska, Jolanta, additional, Mendoza López, Rossana, additional, Luce, Danièle, additional, Macfarlane, Gary, additional, Mates, Dana, additional, Matsuo, Keitaro, additional, McClean, Michael, additional, Menezes, Ana, additional, Menvielle, Gwenn, additional, Morgenstern, Hal, additional, Moysich, Kirsten, additional, Negri, Eva, additional, Olshan, Andrew F., additional, Pandics, Tamas, additional, Polesel, Jerry, additional, Purdue, Mark, additional, Radoi, Loredana, additional, Ramroth, Heribert, additional, Richiardi, Lorenzo, additional, Schantz, Stimson, additional, Schwartz, Stephen M., additional, Serraino, Diego, additional, Shangina, Oxana, additional, Smith, Elaine, additional, Sturgis, Erich M., additional, Świątkowska, Beata, additional, Thomson, Peter, additional, Vaughan, Thomas L., additional, Vilensky, Marta, additional, Winn, Deborah M., additional, Wunsch‐Filho, Victor, additional, Yu, Guo‐Pei, additional, Zevallos, Jose P., additional, Zhang, Zuo‐Feng, additional, Zheng, Tongzhang, additional, Znaor, Ariana, additional, Boffetta, Paolo, additional, Hashibe, Mia, additional, Lee, Yuan‐Chin A., additional, and Muscat, Joshua E., additional

Published
2022
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40. Erratum to: Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

Author

Nicolotti, Nicola, Chuang, Shu-Chun, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, Cristina, Brenner, Hermann, Hosono, Satoyo, La Vecchia, Carlo, Talamini, Renato, Matsuo, Keitaro, Müller, Heiko, Muscat, Joshua, Paludetti, Gaetano, Ricciardi, Gualtiero, Boffetta, Paolo, Hashibe, Mia, and Boccia, Stefania

Published
2011

41. Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

Author

Nicolotti, Nicola, Chuang, Shu-Chun, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, Cristina, Brenner, Hermann, Hosono, Satoyo, La Vecchia, Carlo, Talamini, Renato, Matsuo, Keitaro, Müller, Heiko, Muscat, Joshua, Paludetti, Gaetano, Ricciardi, Gualtiero, Boffetta, Paolo, Hashibe, Mia, and Boccia, Stefania

Published
2011

42. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author

Bravi, Francesca, Lee, Yuan‐Chin Amy, Hashibe, Mia, Boffetta, Paolo, Conway, David I., Ferraroni, Monica, La Vecchia, Carlo, Edefonti, Valeria, Agudo, Antonio, Ahrens, Wolfgang, Benhamou, Simone, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Chuang, Shu‐Chun, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., D'Souza, Gypsyamber, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Gross, Neil D., Hayes, Richard B., Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Gary J., Mates, Dana, Matsuo, Keitaro, McClean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moyses, Raquel A., Moysich, Kirsten, Muscat, Joshua, Negri, Eva, Olshan, Andrew F., Pandics, Tamas, Polesel, Jerry, Purdue, Mark P., Radoï, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M., Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M., Świątkowska, Beata, Thomson, Peter, Toporcov, Tatiana N., Vaughan, Thomas L., Vilensky, Marta, Winn, Deborah M., Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zevallos, Jose P, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y.-C.A., Hashibe M., Boffetta P., Conway D.I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S.-C., Curado M.P., Dal Maso L., Daudt A.W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N.D., Hayes R.B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G.J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R.A., Moysich K., Muscat J., Negri E., Olshan A.F., Pandics T., Polesel J., Purdue M.P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S.M., Serraino D., Shangina O., Smith E., Sturgis E.M., Swiatkowska B., Thomson P., Toporcov T.N., Vaughan T.L., Vilensky M., Winn D.M., Wunsch-Filho V., Yu G.-P., Zevallos J.P., Zhang Z.-F., Zheng T., and Znaor A.

Subjects
INHANCE, medicine.medical_specialty, Oral health, Cancer recurrence, Article, Tobacco Use, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology, medicine, Humans, pooled analysi, prognostic factor, General Dentistry, Beneficial effects, Head and Neck Neoplasm, business.industry, Incidence (epidemiology), Head and neck cancer, oral cavity cancer, Case-control study, prognostic factors, 030206 dentistry, medicine.disease, risk factor, Otorhinolaryngology, Head and Neck Neoplasms, Case-Control Studies, 030220 oncology & carcinogenesis, Family medicine, Etiology, laryngeal cancer, head and neck cancer, Settore MED/31 - OTORINOLARINGOIATRIA, pooled analysis, Neoplasm Recurrence, Local, Case-Control Studie, business, Human
Abstract

Objective:\ud \ud To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium.\ud \ud Subjects and Methods:\ud \ud INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview.\ud \ud Results:\ud \ud Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively.\ud \ud Conclusions:\ud \ud The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.

Published
2020

43. Postural control and disability in patients with early rheumatoid arthritis

Author

De Lorenzis, Enrico, primary, Crudo, Fabrizio, additional, Fedele, Anna Laura, additional, Fiorita, Antonella, additional, Bruno, Dario, additional, Paludetti, Gaetano, additional, Alivernini, Stefano, additional, Giraldi, Luca, additional, Picciotti, Pasqualina Maria, additional, Zoli, Angelo, additional, and Cadoni, Gabriella, additional

Published
2021
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44. Immunohistochemical detection of “ex novo”HLA‐DRin tumor cells determines clinical outcome in laryngeal cancer patients

Author

Prampolini, Chiara, primary, Almadori, Giovanni, additional, Bonvissuto, Davide, additional, Barba, Marta, additional, Giraldi, Luca, additional, Boccia, Stefania, additional, Paludetti, Gaetano, additional, Galli, Jacopo, additional, Parolini, Ornella, additional, Settimi, Stefano, additional, and Cadoni, Gabriella, additional

Published
2021
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46. Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Author

Lesseur, Corina, Ferreiro-Iglesias, Aida, McKay, James D., Bossé, Yohan, Johansson, Mattias, Gaborieau, Valerie, Landi, Maria Teresa, Christiani, David C., Caporaso, Neil C., Bojesen, Stig E., Amos, Christopher I., Shete, Sanjay, Liu, Geoffrey, Rennert, Gadi, Albanes, Demetrios, Aldrich, Melinda C., Tardon, Adonina, Chen, Chu, Triantafillos, Liloglou, Field, John K., Teare, Marion Dawn, Kiemeney, Lambertus A., Diergaarde, Brenda, Ferris, Robert L., Zienolddiny, Shanbeh, Lam, Stephen, Olshan, Andrew F., Weissler, Mark C., Lacko, Martin, Risch, Angela, Bickeböller, Heike, Ness, Andy R., Thomas, Steve, Le Marchand, Loic, Schabath, Matthew B., Wünsch-Filho, Victor, Tajara, Eloiza H., Andrew, Angeline S., Clifford, Gary M., Lazarus, Philip, Grankvist, Kjell, Johansson, Mikael, Arnold, Susanne, Melander, Olle, Brunnström, Hans, Boccia, Stefania, Cadoni, Gabriella, Timens, Wim, Obeidat, Ma'en, Xiao, Xiangjun, Houlston, Richard S., Hung, Rayjean J., Brennan, Paul, Lesseur, Corina, Ferreiro-Iglesias, Aida, McKay, James D., Bossé, Yohan, Johansson, Mattias, Gaborieau, Valerie, Landi, Maria Teresa, Christiani, David C., Caporaso, Neil C., Bojesen, Stig E., Amos, Christopher I., Shete, Sanjay, Liu, Geoffrey, Rennert, Gadi, Albanes, Demetrios, Aldrich, Melinda C., Tardon, Adonina, Chen, Chu, Triantafillos, Liloglou, Field, John K., Teare, Marion Dawn, Kiemeney, Lambertus A., Diergaarde, Brenda, Ferris, Robert L., Zienolddiny, Shanbeh, Lam, Stephen, Olshan, Andrew F., Weissler, Mark C., Lacko, Martin, Risch, Angela, Bickeböller, Heike, Ness, Andy R., Thomas, Steve, Le Marchand, Loic, Schabath, Matthew B., Wünsch-Filho, Victor, Tajara, Eloiza H., Andrew, Angeline S., Clifford, Gary M., Lazarus, Philip, Grankvist, Kjell, Johansson, Mikael, Arnold, Susanne, Melander, Olle, Brunnström, Hans, Boccia, Stefania, Cadoni, Gabriella, Timens, Wim, Obeidat, Ma'en, Xiao, Xiangjun, Houlston, Richard S., Hung, Rayjean J., and Brennan, Paul

Abstract

Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs12133735, near MDM4), 5q31.2 (rs13181561, TMEM173) and 19p13.11 (rs61494113, ABHD8). Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 (ADH1B), 6p21.33 (STK19), 6p21.32 (HLA-DQB1), 9p21.33 (CDKN2B-AS1) and 13q13.1(BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites.

Published
2021
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47. Postural control and disability in patients with early rheumatoid arthritis

Author

De Lorenzis, E., Crudo, Fabrizio, Fedele, Anna Laura, Fiorita, Antonella, Bruno, Dario, Paludetti, Gaetano, Alivernini, Stefano, Giraldi, Luca, Picciotti, Pasqualina Maria, Zoli, Angelo, Cadoni, Gabriella, Crudo F., Fedele A. L., Fiorita A., Bruno D., Paludetti G. (ORCID:0000-0003-2480-1243), Alivernini S. (ORCID:0000-0002-7383-4212), Giraldi L., Picciotti P. M. (ORCID:0000-0002-1502-6508), Zoli A. (ORCID:0000-0003-1597-058X), Cadoni G. (ORCID:0000-0001-8244-784X), De Lorenzis, E., Crudo, Fabrizio, Fedele, Anna Laura, Fiorita, Antonella, Bruno, Dario, Paludetti, Gaetano, Alivernini, Stefano, Giraldi, Luca, Picciotti, Pasqualina Maria, Zoli, Angelo, Cadoni, Gabriella, Crudo F., Fedele A. L., Fiorita A., Bruno D., Paludetti G. (ORCID:0000-0003-2480-1243), Alivernini S. (ORCID:0000-0002-7383-4212), Giraldi L., Picciotti P. M. (ORCID:0000-0002-1502-6508), Zoli A. (ORCID:0000-0003-1597-058X), and Cadoni G. (ORCID:0000-0001-8244-784X)

Abstract

PMID: 33427617 Abstract Objectives: Rheumatoid arthritis (RA) may affect the postural control through abnormal sensory inputs and impaired motor responses. Sensory Organization Test (SOT) objectively evaluates contribution of different sensorial afferences in postural control. The aim of the study is to assess mechanisms of postural instability and their relations with disability and disease characteristics in an early RA(ERA) cohort. Methods: The equilibrium scores were assessed in 30 ERA patients and 30 age- and sex-matched controls. The somatosensory (SOM), visual (VIS) and vestibular (VEST) ratios were computed to assess the use of different sensory and the composite equilibrium score (CES) as a measure of global balance performance. Results: ERA patients had lower CES (78.4±6.0% vs. 83.4±5.0%, p=0.002), SOM ratio (98.5±1.8% vs. 99.6±2.1%, p=0.035), VIS ratio (85.2±7.6% vs. 91.5±6.0%, p=0.001) and VEST ratio (70.8±10.0% vs. 80.3±7.8%, p<0.001) compared to controls. The presence of ankle arthritis correlated negatively to both SOM (r=-0.369, p=0.045) and VIS ratio (r=0.470, p=0.009), pain severity to CES (r=-0.389, p=0.045) and VIS ratio (r=-0.385, p=0.048) and HAQ-DI to CES (r=-0.591, p=0.001), SOM (r=-0.510, p=0.004) and VIS ratio (r=-0.390, p=0.033.). Patients-reported postural instability was associated with lower CES (75.4±5.4% vs. 80.7±5.5%, p=0.016) and VEST ratios (66.5±10.1% vs. 74.1±8.8%, p=0.036). SOT outcomes did not differ according to acute phase reactants, disease activity or autoantibody positivity. Conclusions: RA patients showed an early impairment of postural control related to the degree of disability and subjective postural instability. Our data suggest that the lack of balance could result from both impaired motor response and abnormal sensory organisation.

Published
2021

48. Immunohistochemical detection of “ex novo” HLA-DR in tumor cells determines clinical outcome in laryngeal cancer patients

Author

Prampolini, Chiara, Almadori, Giovanni, Bonvissuto, Davide, Barba, Marta, Giraldi, Luca, Boccia, Stefania, Paludetti, Gaetano, Galli, Jacopo, Parolini, Ornella, Settimi, Stefano, Cadoni, Gabriella, Prampolini C., Almadori G. (ORCID:0000-0002-4605-2442), Bonvissuto D., Barba M. (ORCID:0000-0001-6084-7666), Giraldi L., Boccia S. (ORCID:0000-0002-1864-749X), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Parolini O. (ORCID:0000-0002-5211-6430), Settimi S. (ORCID:0000-0003-0104-1501), Cadoni G. (ORCID:0000-0001-8244-784X), Prampolini, Chiara, Almadori, Giovanni, Bonvissuto, Davide, Barba, Marta, Giraldi, Luca, Boccia, Stefania, Paludetti, Gaetano, Galli, Jacopo, Parolini, Ornella, Settimi, Stefano, Cadoni, Gabriella, Prampolini C., Almadori G. (ORCID:0000-0002-4605-2442), Bonvissuto D., Barba M. (ORCID:0000-0001-6084-7666), Giraldi L., Boccia S. (ORCID:0000-0002-1864-749X), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Parolini O. (ORCID:0000-0002-5211-6430), Settimi S. (ORCID:0000-0003-0104-1501), and Cadoni G. (ORCID:0000-0001-8244-784X)

Abstract

There are controversial results about the role of “ex novo” HLA-DR expression by tumor cells and its correlation with the oncological outcomes. Unfortunately, little is known about HLA-DR expression in laryngeal cancer tumor cells. The main purpose of this retrospective study is to strengthen the usefulness of studying “ex novo” HLA-DR expression on tumor cells from primary laryngeal squamous cell carcinoma (LSCC) patients and investigate its correlation with clinical outcome. We analyzed HLA-DR expression by immunohistochemical analysis in 56 patients with LSCC. The “ex novo” HLA-DR expression on laryngeal cancer tumor cells, assessing non-neoplastic LSCC – adjacent tissue, and the association of HLA-DR expression (HLA-DR+) with clinical outcomes were investigated. HLA-DR+ tumor cells were detected in 18/56 LSCC patients (32.1%). All specimens of non-neoplastic laryngeal carcinoma-adjacent tissue resulted HLA-DR negative (HLA-DR-). A statistically significant association was observed between HLA-DR + and well differentiated tumors (G1) (p<0.001). The Kaplan-Meier method showed how HLA-DR+ is significantly associated with both a better disease specific survival (HLA-DR+=100% vs. HLA-DR-=77.4%; p=0.047) and a better relapse free survival (HLA-DR+=100% vs. HLA-DR-=72.3%; p=0.021). Cox regression univariate analysis for death of disease confirmed a higher HR for HLA-DR absence on the surface of epithelial tumor cell [HR:37.489; 95% CI:0.750-18730.776; p=0.253] and for high-grade (G3) tumors [HR:18.601; 95% CI:3.613-95.764; p<0.0001]. Our results confirm that MHC class II HLA-DR expression is activated in a sub-set of LSCC patients. Evaluation of HLA-DR expression in LSCC could be useful for prognosis and future approaches towards personalized therapy.

Published
2021

49. Erratum to 'Prognostic Role of Serum Amino Acids in Head and Neck Cancer'

Author

Cadoni, Gabriella, Giraldi, Luca, Chiarla, Carlo, Gervasoni, Jacopo, Persichilli, Silvia, Primiano, A., Settimi, Stefano, Galli, Jacopo, Paludetti, Gaetano, Arzani, D., Boccia, Stefania, Giovannini, Ivo, Almadori, Giovanni, Cadoni G. (ORCID:0000-0001-8244-784X), Giraldi L., Chiarla C. (ORCID:0000-0001-9403-433X), Gervasoni J., Persichilli S. (ORCID:0000-0002-7955-8810), Settimi S. (ORCID:0000-0003-0104-1501), Galli J. (ORCID:0000-0001-6353-6249), Paludetti G. (ORCID:0000-0003-2480-1243), Boccia S. (ORCID:0000-0002-1864-749X), Giovannini I., Almadori G. (ORCID:0000-0002-4605-2442), Cadoni, Gabriella, Giraldi, Luca, Chiarla, Carlo, Gervasoni, Jacopo, Persichilli, Silvia, Primiano, A., Settimi, Stefano, Galli, Jacopo, Paludetti, Gaetano, Arzani, D., Boccia, Stefania, Giovannini, Ivo, Almadori, Giovanni, Cadoni G. (ORCID:0000-0001-8244-784X), Giraldi L., Chiarla C. (ORCID:0000-0001-9403-433X), Gervasoni J., Persichilli S. (ORCID:0000-0002-7955-8810), Settimi S. (ORCID:0000-0003-0104-1501), Galli J. (ORCID:0000-0001-6353-6249), Paludetti G. (ORCID:0000-0003-2480-1243), Boccia S. (ORCID:0000-0002-1864-749X), Giovannini I., and Almadori G. (ORCID:0000-0002-4605-2442)

Abstract

[This corrects the article DOI: 10.1155/2020/2291759.].

Published
2021
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50. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author

Bravi, F., Lee, Y. -C. A., Hashibe, M., Boffetta, Paolo, Conway, D. I., Ferraroni, M., La Vecchia, C., Edefonti, V., Agudo, A., Ahrens, W., Benhamou, S., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Chuang, S. -C., Curado, M. P., Dal Maso, L., Daudt, A. W., D'Souza, G., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Gross, N. D., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kelsey, K., Kjaerheim, K., Koifman, R., Lagiou, Pagona, Lazarus, P., Levi, F., Li, G., Lissowska, J., Luce, D., Macfarlane, G. J., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moyses, R. A., Moysich, K., Muscat, J., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M. P., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Toporcov, T. N., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., Negri E., Bravi, F., Lee, Y. -C. A., Hashibe, M., Boffetta, Paolo, Conway, D. I., Ferraroni, M., La Vecchia, C., Edefonti, V., Agudo, A., Ahrens, W., Benhamou, S., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Chuang, S. -C., Curado, M. P., Dal Maso, L., Daudt, A. W., D'Souza, G., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Gross, N. D., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kelsey, K., Kjaerheim, K., Koifman, R., Lagiou, Pagona, Lazarus, P., Levi, F., Li, G., Lissowska, J., Luce, D., Macfarlane, G. J., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moyses, R. A., Moysich, K., Muscat, J., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M. P., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Toporcov, T. N., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., and Negri E.

Abstract

Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.

Published
2021

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