628 results on '"Caddick, Stephen"'
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2. Post-translational site-selective protein backbone α-deuteration
3. Functionalized cyclopentenones with low electrophilic character as new anticancer agents
4. The triflic acid mediated reactions of benzo-fused cyclic amides
5. Optical control of trimeric P2X receptors and acid-sensing ion channels
6. Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents.
7. The triflic acid-mediated cyclisation of N-benzylcinnamanilides
8. The acid-mediated ring opening/cyclisation reaction of N-benzyl-α-aryl-azetidinones
9. Microwave enhanced synthesis
10. Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors
11. DFT studies of reductive elimination, C–H activation and β-hydride elimination in alkyl and aryl palladium amine complexes
12. Hydroacylation of α,β-unsaturated esters via aerobic C–H activation
13. Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ob03138f
14. Correction: Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
15. Studies on high-temperature amination reactions of aromatic chlorides using discrete Palladium-N-Heterocyclic Carbene (NHC) complexes and in situ palladium/imidazolium salt protocols
16. Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein
17. The design, synthesis and pharmacological characterization of novel β2-adrenoceptor antagonists
18. A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics
19. Inhibition of HIV-1 Replication by Isoxazolidine and Isoxazole Sulfonamides
20. Aspects of free radical cyclisation
21. Studies on Pd/imidazolium salt protocols for aminations of aryl bromides and iodides using lithium hexamethyldisilazide (LHMDS)
22. On the efficiency of two-coordinate palladium(0) N-heterocyclic carbene complexes in amination and Suzuki–Miyaura reactions of aryl chlorides
23. Wiki and other ways to share learning online
24. Kinetic resolution of 4,5-dihydroxylated cyclopentenones
25. A generic approach for the catalytic reduction of nitriles
26. A Plug-and-Play Approach for the De Novo Generation of Dually Functionalised Bispecifics
27. Next-generation disulfide stapling: reduction and functional re-bridging all in one† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra for all small molecules, LC-MS, SDS-PAGE gels and UV-Vis analysis (where applicable) for all bioconjugates. See DOI: 10.1039/c5sc02666k Click here for additional data file
28. A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation† †Electronic supplementary information (ESI) available: Full experimental details are provided. See DOI: 10.1039/c5ob00130g Click here for additional data file
29. Rationalising diastereoselection in the dynamic kinetic resolution of α-haloacyl imidazolidinones: a theoretical approach
30. Synthesis of α-amino esters by dynamic kinetic resolution of α-haloacyl imidazolidinones
31. A convenient and practical method for the selective benzoylation of primary hydroxyl groups using microwave heating
32. An improved synthesis of bis(1,3-di- N- tert-butylimidazol-2-ylidene)palladium(0) and its use in C–C and C–N coupling reactions
33. Don't get lost in translation
34. Solid-phase intermolecular radical reactions 1. Sulfonyl radical addition to isolated alkenes and alkynes
35. Reversible protein affinity-labelling using bromomaleimide-based reagents† †Electronic supplementary information (ESI) available: 1H and 13C spectra for all new and known compounds, and ES-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c3ob40239hClick here for additional data file
36. Protein modification, bioconjugation, and disulfide bridging using bromomaleimides
37. Axial coordination of NHC ligands on dirhodium(II) complexes: generation of a new family of catalysts
38. Making for a better world
39. Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody
40. Use of a next generation maleimide in combination with THIOMAB™ antibody technology delivers a highly stable, potent and near homogeneous THIOMAB™ antibody-drug conjugate (TDC)
41. Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering
42. Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
43. Direct synthesis of sulfonamides and activated sulfonate esters from sulfonic acids
44. A Plug-and-Play Approach for the De NovoGeneration of Dually Functionalized Bispecifics
45. Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation† †Electronic supplementary information (ESI) available: 1H and 13C spectra for all novel compounds, and ES-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c3cc45220dClick here for additional data file
46. A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones
47. TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells
48. Erratum: Corrigendum: Recent advances in the construction of antibody–drug conjugates
49. Recent advances in the construction of antibody–drug conjugates
50. Next-generation disulfide stapling: reduction and functional re-bridging all in one
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