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2 results on '"Caccialupi, M"'

1. Study of growth in Chinese children, 0-3 aged, living in Bologna (Italy). A preliminary report

Author

Toselli, S., Emanuela Gualdi-Russo, Ruffilli, I., Caccialupi, M. G., Toselli S., Gualdi-Russo E., Ruffilli I., and Caccialupi M.G.

Subjects
Anthropometry, Chinese children, Growth, Zhejiang
Abstract

This paper is a preliminary report of an ongoing longitudinal study aimed at evaluating the growth of Chinese children living in Bologna. The auxological data for boys and girls were collected from birth to 3 years of age. The growth process was assessed by means of anthropometric measurements, including body length, weight and head circumference. These traits were analyzed with respect to international standards or the results of other studies. In addition, some main family characteristics are described. Our sample of Chinese-Italian children aged 0-3 years did not show the growth faltering observed in other studies of Chinese children. Conversely, these subjects developped according to the NCHS reference standards and to the observations reported for Italian children living in the same region (Emilia-Romagna). There was a slight decrease in weight and length rate only after the age of 12-18 months.

Published
2001

2. Independent and joint effects of the MAPT and SNCA genes in Parkinson disease

Author

Elbaz, A, Ross, Oa, Ioannidis, Jp, Soto Ortolaza, Ai, Aasly, J, Bozi, M, Chartier Harlin, Mc, Destée, A, Ferrarese, C, Ferraris, A, Gibson, Jm, Hadjigeorgiou, Gm, Jasinska Myga, B, Klein C, Krüger R, Lohmann, K, Loriot, Ma, Mellick, Gd, Mutez, E, Nilsson, C, Puschmann, A, Quattrone, A, Sharma, M, Silburn, Pa, Stefanis, L, Valente, Em, Vilariño Güell, C, Wirdefeldt, K, Wszolek, Zk, Xiromerisiou, G, Farrer, Mj, Amouyel, P, Tzourio, C, Mulot, C, Bacon, Ja, Cobb, Sa, Sutherland, Gt, Siebert, Ga, Dissanayaka, N, O'Sullivan, Jd, Boyle, R, Bordet, R, Legendre, Jp, Auburger, G, Abahuni, N, Winkler, S, Gasser, T, Riess, O, Berg, D, Schulte, C, Vassilatis, D, Stamboulis, E, Dardiotis, E, Patramani, I, Kountra, Pm, Vogiatzi, C, Markou, K, Tarantino, P, Annesi, F, Bentivoglio, Anna Rita, Guidubaldi, Arianna, Caccialupi, M, De Nigris, Francesca, Pedersen, Nl, Reimer, J, Lash, J, Searcy, J, Strongosky, A., Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Elbaz, A, Ross, Oa, Ioannidis, Jp, Soto Ortolaza, Ai, Aasly, J, Bozi, M, Chartier Harlin, Mc, Destée, A, Ferrarese, C, Ferraris, A, Gibson, Jm, Hadjigeorgiou, Gm, Jasinska Myga, B, Klein C, Krüger R, Lohmann, K, Loriot, Ma, Mellick, Gd, Mutez, E, Nilsson, C, Puschmann, A, Quattrone, A, Sharma, M, Silburn, Pa, Stefanis, L, Valente, Em, Vilariño Güell, C, Wirdefeldt, K, Wszolek, Zk, Xiromerisiou, G, Farrer, Mj, Amouyel, P, Tzourio, C, Mulot, C, Bacon, Ja, Cobb, Sa, Sutherland, Gt, Siebert, Ga, Dissanayaka, N, O'Sullivan, Jd, Boyle, R, Bordet, R, Legendre, Jp, Auburger, G, Abahuni, N, Winkler, S, Gasser, T, Riess, O, Berg, D, Schulte, C, Vassilatis, D, Stamboulis, E, Dardiotis, E, Patramani, I, Kountra, Pm, Vogiatzi, C, Markou, K, Tarantino, P, Annesi, F, Bentivoglio, Anna Rita, Guidubaldi, Arianna, Caccialupi, M, De Nigris, Francesca, Pedersen, Nl, Reimer, J, Lash, J, Searcy, J, Strongosky, A., and Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X)

Abstract

OBJECTIVE: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. METHODS: Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach. RESULTS: Fifteen GEO-PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1-haplotype-defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 3' end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. INTERPRETATION: This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects.

Published
2011

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