Search

Your search keyword '"Cacabelos, Ramón"' showing total 571 results
Start Over Author "Cacabelos, Ramón"
571 results on '"Cacabelos, Ramón"'

1. Progress in Pharmaceutical Sciences and Future Challenges.

Author

Cacabelos, Ramón

Subjects
*DRUG side effects, *THERAPEUTICS, *MEDICAL practice, *DRUG solubility, *ALZHEIMER'S disease, *ADALIMUMAB, *BUPRENORPHINE, *PHARMACOGENOMICS
Abstract

The document highlights significant advancements in pharmaceutical sciences from 1999 to 2024, including targeted cancer therapies, immunotherapy, gene editing, and antiviral treatments. It also discusses future challenges in treating cardiovascular diseases, cancer, and central nervous system disorders, emphasizing the importance of personalized medicine, overcoming drug resistance, and targeting inflammation. Special therapeutic considerations for neuropsychiatric disorders like schizophrenia, depression, and epilepsy are also addressed, focusing on developing new treatments and improving outcomes through personalized approaches and novel targets. The challenges in pharmacological treatments for various diseases underscore the need for continued research and innovation in drug development. [Extracted from the article]

Published
2024
Full Text
View/download PDF

2. Therapeutic Options in Alzheimer's Disease: From Classic Acetylcholinesterase Inhibitors to Multi-Target Drugs with Pleiotropic Activity.

Author

Cacabelos, Ramón, Martínez-Iglesias, Olaia, Cacabelos, Natalia, Carrera, Iván, Corzo, Lola, and Naidoo, Vinogran

Subjects
*ALZHEIMER'S disease, *ACETYLCHOLINESTERASE inhibitors, *BIOTECHNOLOGY, *DRUG development, *BIOLOGICAL products, *DONEPEZIL
Abstract

Alzheimer's disease (AD) is a complex/multifactorial brain disorder involving hundreds of defective genes, epigenetic aberrations, cerebrovascular alterations, and environmental risk factors. The onset of the neurodegenerative process is triggered decades before the first symptoms appear, probably due to a combination of genomic and epigenetic phenomena. Therefore, the primary objective of any effective treatment is to intercept the disease process in its presymptomatic phases. Since the approval of acetylcholinesterase inhibitors (Tacrine, Donepezil, Rivastigmine, Galantamine) and Memantine, between 1993 and 2003, no new drug was approved by the FDA until the advent of immunotherapy with Aducanumab in 2021 and Lecanemab in 2023. Over the past decade, more than 10,000 new compounds with potential action on some pathogenic components of AD have been tested. The limitations of these anti-AD treatments have stimulated the search for multi-target (MT) drugs. In recent years, more than 1000 drugs with potential MT function have been studied in AD models. MT drugs aim to address the complex and multifactorial nature of the disease. This approach has the potential to offer more comprehensive benefits than single-target therapies, which may be limited in their effectiveness due to the intricate pathology of AD. A strategy still unexplored is the combination of epigenetic drugs with MT agents. Another option could be biotechnological products with pleiotropic action, among which nosustrophine-like compounds could represent an attractive, although not definitive, example. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Contributors

Author

Bainomugisa, Charlotte, primary, Baker, Dewleen G., additional, Boks, Marco P., additional, Braný, Dušan, additional, Busogi, Belinda U., additional, Cacabelos, Ramón, additional, Cleveland, Shiloh, additional, Dela Cruz, Sonia, additional, van den Hove, Daniel, additional, Dvorská, Dana, additional, Escoto, Alana I.H., additional, Fries, Gabriel R., additional, Gage, Fred H., additional, Halldorsdottir, Thorhildur, additional, Hao, Guang, additional, Hauger, Richard L., additional, Hsu, Aileen, additional, Jeong, Annie, additional, Kamath, Jayesh, additional, Kenis, Gunter, additional, Lee, Richard S., additional, Lockwood, Laura, additional, Martínez-Iglesias, Olaia, additional, Mehta, Divya, additional, Montalvo-Ortiz, Janitza L., additional, Naidoo, Vinogran, additional, Nguyen, Jessica, additional, Nievergelt, Caroline M., additional, de Nijs, Laurence, additional, Nishitani, Shota, additional, O’Neill, Jeffrey, additional, Ölmez, Safiye Bahar, additional, Patel, Aarti, additional, Patel, Bhargav, additional, Patel, Parit, additional, Pittman, Demietrice, additional, Reed, Kristina, additional, Rutten, Bart P.F., additional, Salarda, Erika M., additional, Snijders, Clara, additional, Strnádel, Ján, additional, Su, Arthur, additional, Su, Shaoyong, additional, Sumner, Jennifer A., additional, Thomas, Jordan, additional, Valdimarsdottir, Heiddis B., additional, Valdimarsdottir, Unnur A., additional, Vermetten, Eric, additional, Walker, Sophia, additional, Yılmaz, Onur, additional, Youssef, Nagy A., additional, and Zhang, Sheila, additional

Published
2022
Full Text
View/download PDF

14. Pharmacogenomics of Antidepressant Drugs

Author

Cacabelos, Ramón, Torrellas, Clara, López-Muñoz, Francisco, López-Muñoz, Francisco, editor, Srinivasan, Venkataramanujam, editor, de Berardis, Domenico, editor, Álamo, Cecilio, editor, and Kato, Takahiro A., editor

Published
2016
Full Text
View/download PDF

23. Contributors

Author

Abou Diwan, E., primary, Andersen, Jesper B., additional, Aslani, Saeed, additional, Baenas, Nieves, additional, Baer-Dubowska, Wanda, additional, Banerjee, Moinak, additional, Baune, Bernhard T., additional, Belhadj, Ahlem, additional, Biron, Vincent L., additional, Bousman, Chad, additional, Cacabelos, Ramón, additional, Cacabelos, Pablo, additional, Carril, Juan C., additional, Castro-Santos, P., additional, Chen, Si, additional, Cheng, Yuanyuan, additional, Chidambaram, Anusha, additional, Chidambaram, Ramesh Kumar, additional, Cunha-Oliveira, Teresa, additional, Daifuku, Richard, additional, Damaskos, Christos, additional, Díaz-Peña, R., additional, Dimitroulis, Dimitrios, additional, Dincer, Yıldız, additional, DiStefano, Johanna K., additional, Dupper, Nathan J., additional, Dutta, Dibyendu, additional, Eid, Aseel, additional, Eyre, Harris A., additional, Feng, Qian, additional, Ferreira, Luciana L., additional, Fries, Gabriel R., additional, Garmpi, Anna, additional, Garmpis, Nikolaos, additional, Govin, Jérôme, additional, Guerra, Joaquín, additional, Guo, Lei, additional, Halayem, Soumeyya, additional, Hamza, Meriem, additional, Hartley, Antja-Voy, additional, He, Rong-Rong, additional, Hedrich, Christian Michael, additional, Huang, Zhiying, additional, Huang, Qiuju, additional, Hwang, Eun Seong, additional, Jin, Jiamin, additional, Kostiuk, Morris, additional, Kovalchuk, Olga, additional, Kovalchuk, Igor, additional, Li, Dongying, additional, Lim, Seah H., additional, Lindsay, Cameron, additional, Liu, Bo, additional, Liu, Hong-Min, additional, Liu, Zhongqiu, additional, Lu, Linlin, additional, Lu, Tao, additional, Mahmoudi, Mahdi, additional, Majchrzak-Celińska, Aleksandra, additional, Martin, Matthew, additional, McKenna, Charles E., additional, Miyake, Kunio, additional, Mrad, Ridha, additional, Munoz-Garrido, Patricia, additional, Nasr, R., additional, Ning, Baitang, additional, Noguchi-Yachide, Tomomi, additional, O’Rourke, Colm J., additional, Oliveira, Douglas V.N.P., additional, Oliveira, Paulo J., additional, Polakkattil, Binithamol K., additional, Quevedo, Joao, additional, Rezaei, Ramazan, additional, Richardson, Jason R., additional, Saavedra, Kathleen, additional, Salazar, Luis A., additional, Sanmartín, Ana, additional, Satriano, Letizia, additional, Sidler, Corinne, additional, Su, Tao, additional, Swathy, Babu, additional, Teijido, Oscar, additional, Tellado, Iván, additional, Tolleson, William H., additional, Tong, Weida, additional, Vilwanathan, Ravikumar, additional, Tran, Nguyen Quoc Vuong, additional, Valsami, Serena, additional, Wagner, Anika E., additional, Watanabe, Richard M., additional, Xiao, Wenming, additional, Yu, Dianke, additional, Yu, Bin, additional, Zambrano, Tomás, additional, Zeitoun, R., additional, Zgheib, N.K., additional, and Zhou, Yingsheng, additional

Published
2019
Full Text
View/download PDF

32. Potential Preventive Effects of Coenzyme Q and Creatine Supplementation on Brain Energy Metabolism in Rats Exposed to Chronic Cerebral Hypoperfusion

Author

Aliev, Gjumrakch, Ashraf, Ghulam Md, Horecký, Jaromir, Vančová, Olga, Gvozdjáková, Anna, Kucharská, Jarmila, Palacios, Hector H., Li, Yi, Perveen, Asma, Khan, Taqi Ahmed, Bragin, Valentin, Bragin, Ilya, Shevtsova, Elena, Klochkov, Sergey G., Kosenko, Elena A., Cacabelos, Ramon, Kaminsky, Yury G., Sudakov, Konistantin V., Benberin, Valery V., Bachurin, Sergey O., and Laher, Ismail, editor

Published
2014
Full Text
View/download PDF

40. List of Contributors

Author

Abdel-Rahman, Emaad M., primary, Ackerman, Hayley D., additional, Akintola, Abimbola, additional, Amdam, Gro V., additional, Atzmon, Gil, additional, Austad, Steve, additional, Awate, Sanket, additional, Balaskó, Márta, additional, Banerjee, Taraswi, additional, Bárcena, Clea, additional, Bartke, Andrzej, additional, Bassi, Ivan, additional, Berendt, Mette, additional, Bijlsma, Maarten F., additional, Bitto, Alessandro, additional, Bizon, Jennifer L., additional, Bollaerts, Ilse, additional, Bonomi, Marco, additional, Borras, Consuelo, additional, Bowman, Brendan T., additional, Brioche, Thomas, additional, Brosh, Robert M., additional, Brown, Richard E., additional, Buck, Kerstin, additional, Burke, Sara N., additional, Buzgariu, Wanda, additional, Cacabelos, Ramón, additional, Camina Martín, M.A., additional, Chaffee, Beth K., additional, Chan, Anthony W.S., additional, Chen, Haolin, additional, Chen, Zhiguo, additional, Cho, In K., additional, Chopard, Angèle, additional, Cogger, Victoria C., additional, Cohen, Alan A., additional, Confino, Rafael, additional, Coppedè, Fabio, additional, Costa, Anthony J., additional, Crouch, Jack D., additional, Darcy, Justin, additional, De Groef, Lies, additional, de Mateo Silleras, B., additional, Deepa, Sathyaseelan S., additional, Devau, Gina, additional, Dhenain, Marc, additional, Dills, Chantelle, additional, Duffy, Megan F., additional, Duncan, Francesca E., additional, Dupuis, Gilles, additional, Eaton, Benjamin A., additional, Egan, Josephine M., additional, Ekundayo, Kazadi, additional, Emborg, Marina E., additional, Fischer, D. Luke, additional, Fontes, Pascaline, additional, Fortepiani, Maria Lourdes Alarcon, additional, Fortin, Carl, additional, Franzke, Bernhard, additional, Fülöp, Tamas, additional, Gabriel, Camelia, additional, Galliot, Brigitte, additional, Gambini, Juan, additional, Garneau, Hugo, additional, Gasparini, Laura, additional, Gerhard, Glenn S., additional, Gibson, David C., additional, Gimeno-Mallench, Lucia, additional, Girard, Victor, additional, Greer, Kimberly A., additional, Gribble, Kristin E., additional, Gubbels Bupp, Melanie R., additional, Gudmundsson, Adalsteinn, additional, Hamann, Andrea, additional, Hamblin, Michael R., additional, Harper, James M., additional, Hart, Ronald, additional, Head, Elizabeth, additional, Herd, Heather R., additional, Herrera, Guadalupe, additional, Hisama, Fuki M., additional, Hogan, David B., additional, Holmes, Donna J., additional, Hornsby, Peter J., additional, Howlett, Susan E., additional, Hui, Ka Yi, additional, Jahn, Thomas R., additional, Jávega, Beatriz, additional, Jeffery, William R., additional, Johnson, Sarah A., additional, Jones, Audrey, additional, Jones, Corinne A., additional, Jónsson, Pálmi V., additional, Kane, Alice E., additional, Karasik, David, additional, Kean, Samuel, additional, Keller, Evan T., additional, Keller, Jill M., additional, Kemp, Christopher J., additional, Wong, Ken S.K., additional, Krøll, Jens, additional, Kumar Bharti, Sanjay, additional, Kurkinen, Markku, additional, Larbi, Anis, additional, Lasbleiz, Christelle, additional, Lautier, Corinne, additional, Le Couteur, David G., additional, Le Page, Aurelie, additional, Lin, Hang, additional, López-Otín, Carlos, additional, Lottonen-Raikaslehto, Line, additional, Magden, Elizabeth R., additional, Makrantonaki, Evgenia, additional, Manfredsson, Fredric P., additional, Mark Welch, David B., additional, Marques-Lopes, Jose, additional, Martínez-Romero, Alicia, additional, Mas-Bargues, Cristina, additional, Mayoral, Pablo, additional, Mc Auley, Mark, additional, McQuail, Joseph A., additional, Merentie, Mari, additional, Mestre-Frances, Nadine, additional, Metzger, Jeanette M., additional, Meyer, Keith C., additional, Milner, Teresa A., additional, Mizutani, Claudia M., additional, Monnat, Raymond J., additional, Mooney, Kathleen, additional, Moons, Lieve, additional, Muck, Joscha, additional, Muniyappa, Ranganath, additional, Nehlin, Jan O., additional, Neubauer, Oliver, additional, Nikolakis, Georgios, additional, Nyman, Jeffry S., additional, O’Connor, José-Enrique, additional, Oshima, Junko, additional, Osiewacz, Heinz D., additional, Papadopoulos, Vassilios, additional, Pavone, Mary Ellen, additional, Pawelec, Graham, additional, Pedersen, Jan T., additional, Perez-Lopez, Gonzalo, additional, Persani, Luca, additional, Pétervári, Erika, additional, Peyman, Azadeh, additional, Plate, Johannes F., additional, Polinski, Nicole K., additional, Py, Guillaume, additional, Quigley, Tyler P., additional, Rae, Eric A., additional, Ram, Jeffrey L., additional, Raubenheimer, David, additional, Reckelhoff, Jane F., additional, Redondo del Río, M.P., additional, Rex-Al Panem Orbon, Jovy, additional, Richardson, Arlan, additional, Ripperger, Jürgen A., additional, Rostás, Ildikó, additional, Rouse, Michael, additional, Rueppell, Olav, additional, Runge, Kurt W., additional, Safdar, Maryam, additional, Sankaran-Walters, Sumathi, additional, Santago, Anthony C., additional, Sarvimäki, Anneli, additional, Saul, Katherine R., additional, Schenkelaars, Quentin, additional, Schneider, Brandt L., additional, Schütt, Trine, additional, Shen, He, additional, Shin, Sooyoun, additional, Simpson, Stephen J., additional, Smith, Jessica, additional, Snell, Terry W., additional, Snyder, Jessica M., additional, Solon-Biet, Samantha M., additional, Soós, Szilvia, additional, Sortwell, Caryl E., additional, Sousa-Neves, Rui, additional, Steece-Collier, Kathy, additional, Steins, Anne, additional, Sujkowski, Alyson, additional, Swanberg, Susan E., additional, Teijido, Oscar, additional, Tella, Sri Harsha, additional, Tenk, Judit, additional, Tomczyk, Szymon, additional, Treuting, Piper M., additional, Trouche, Stéphanie G., additional, Tuan, Rocky S., additional, Unnikrishnan, Archana, additional, Valenzano, Dario Riccardo, additional, van Heemst, Diana, additional, Van houcke, Jessie, additional, Van Kempen, Tracey A., additional, van Laarhoven, Hanneke W.M., additional, Verdier, Jean-Michel, additional, Viña, Jose, additional, Wagner, Karl-Heinz, additional, Wahl, Devin, additional, Wenger, Yvan, additional, Wessells, Robert J., additional, Wilcock, Donna M., additional, Witkowski, Jacek M., additional, Wong, Esther, additional, Woodland, Nicole, additional, Yanes Cardozo, Licy L., additional, Ylä-Herttuala, Seppo, additional, Youssef, Sameh A., additional, Yuan, Rong, additional, Zhang, Haitao, additional, Zhou, Zhongjun, additional, Zirkin, Barry R., additional, and Zouboulis, Christos C., additional

Published
2018
Full Text
View/download PDF

44. List of Contributors

Author

Adwan-Shekhidem, Huda, primary, Atzmon, Gil, additional, Benayoun, Bérénice A., additional, Bowman, John D., additional, Braun, Kim V.E., additional, Cacabelos, Ramón, additional, Caiafa, Paola, additional, Cao, Xiaohua, additional, Choudhury, Mahua, additional, Chowdhury, Rajiv, additional, Ciccarone, Fabio, additional, Cunliffe, Vincent T., additional, Dang, Weiwei, additional, Dong, Xiao, additional, Eachus, Helen, additional, Franco, Oscar H., additional, Gravina, Silvia, additional, Koliada, Alexander K., additional, Kovalchuk, Igor, additional, Kranjc, Tilen, additional, Kudryavtseva, Anna, additional, Kumar, Vineet, additional, Langley-Evans, Simon C., additional, Loenen, Wil A.M., additional, Lovšin, Nika, additional, Lushchak, Oleh V., additional, Marc, Janja, additional, Meruvu, Sunitha, additional, Mills, Ken I., additional, Mitnitski, Arnold B., additional, Moskalev, Alexey, additional, Muhlhausler, Beverly S., additional, Muka, Taulant, additional, Nano, Jana, additional, O’Sullivan, Justin M., additional, Ostanek, Barbara, additional, Portilla, Eliana, additional, Raj, Ken, additional, Rea, Irene M., additional, Reynolds, Clare M., additional, Schumacher, Axel, additional, Seaborne, Robert A., additional, Segovia, Stephanie A., additional, Shaposhnikov, Mikhail, additional, Sharples, Adam P., additional, Solovev, Ilya, additional, Stewart, Claire E., additional, Teijido, Oscar, additional, Troup, Jenna, additional, Ucar, Duygu, additional, Vaiserman, Alexander M., additional, Verma, Mukesh, additional, Vickers, Mark H., additional, Vijg, Jan, additional, Voortman, Trudy, additional, Xu, Xiangru, additional, Zampieri, Michele, additional, and Zupan, Janja, additional

Published
2018
Full Text
View/download PDF

50. Proteomic and Global DNA Methylation Modulation in Lipid Metabolism Disorders with a Marine-Derived Bioproduct.

Author

Martínez-Iglesias, Olaia, Naidoo, Vinogran, Corzo, Lola, Carrera, Iván, Seoane, Silvia, Rodríguez, Susana, Alcaraz, Margarita, Muñiz, Adriana, Cacabelos, Natalia, and Cacabelos, Ramón

Subjects
LIPID metabolism disorders, DNA methylation, CELL adhesion molecules, PROTEOMICS, LIPIDS, CARDIOVASCULAR diseases, VASCULAR cell adhesion molecule-1, GROSS motor ability
Abstract

Simple Summary: Dyslipidemia is a significant risk factor for cardiovascular disease, and current treatments such as statins can have toxic side effects. RCI-1502, a bioproduct derived from the European S. pilchardus, has shown potential as a natural and less toxic alternative treatment for cardiovascular disorders. Alterations in DNA methylation patterns may contribute to the development and progression of lipid metabolism disorders, including atherosclerosis and other cardiovascular diseases. Alterations in DNA methylation may contribute to the development and progression of lipid metabolism disorders, including atherosclerosis and other cardiovascular disorders. In this study, we conducted proteomic analysis of RCI-1502 extracts and classified the identified proteins by their primary molecular functions using the PANTHER classification system. We furthermore investigated the therapeutic potential of RCI-1502 on gene expression and DNA methylation in a high-fat diet mouse model and in patients with lipid metabolism disorders. RCI-1502 treatment regulated the expression of cardiovascular-related genes and reduced DNA methylation levels in both the high-fat diet model and human samples. Furthermore, RCI-1502 regulated cholesterol and triglyceride levels in dyslipidemic patients. Our findings suggest that RCI-1502 is an epigenetic modulator with promising therapeutic potential for dyslipidemia and associated cardiovascular disorders and highlight the potential of epigenetic modulators in treating lipid metabolism disorders. Future studies could explore the combination of RCI-1502 with established treatments for dyslipidemia. Dyslipidemia is a significant risk factor for cardiovascular disease and stroke. Our recent findings showed that RCI-1502, a bioproduct derived from the muscle of the European S. pilchardus, has lipid-lowering effects in the liver and heart in high-fat diet (HFD) fed mice. In the present follow-up study, we investigated the therapeutic potential of RCI-1502 on gene expression and DNA methylation in HFD-fed mice and in patients with dyslipidemia. Using LC-MS/MS, we identified 75 proteins in RCI-1502 that are primarily involved in binding and catalytic activity and which regulate pathways implicated in cardiovascular diseases. In HFD-fed mice, RCI-1502 treatment significantly reduced the expression of cardiovascular disease-related genes, including vascular cell adhesion molecule and angiotensin. RCI-1502 also decreased DNA methylation levels, which were elevated in HFD-fed mice, to levels similar to those in control animals. Furthermore, peripheral blood leukocyte DNA from dyslipidemic patients exhibited higher DNA methylation levels than healthy individuals, suggesting a potential association with cardiovascular risk. Serum analysis also revealed that RCI-1502 treatment regulated cholesterol and triglyceride levels in patients with dyslipidemia. Our findings appear to suggest that RCI-1502 is an epigenetic modulator for the treatment of cardiovascular diseases, specifically in individuals with dyslipidemia. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results