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1. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients

Author

Partida-Pérez, Miriam, primary, de la Luz Ayala-Madrigal, María, additional, Peregrina-Sandoval, Jorge, additional, Macías-Gómez, Nelly, additional, Moreno-Ortiz, José, additional, Leal-Ugarte, Evelia, additional, Cárdenas-Meza, Mario, additional, Centeno-Flores, Manuel, additional, Maciel-Gutiérrez, Víctor, additional, Cabrales, Enrique, additional, Cervantes-Ortiz, Sergio, additional, and Gutiérrez-Angulo, Melva, additional

Published
2011
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2. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients.

Author

Partida-Pérez M, de la Luz Ayala-Madrigal M, Peregrina-Sandoval J, Macías-Gómez N, Moreno-Ortiz J, Leal-Ugarte E, Cárdenas-Meza M, Centeno-Flores M, Maciel-Gutiérrez V, Cabrales E, Cervantes-Ortiz S, and Gutiérrez-Angulo M

Subjects
Adiponectin genetics, Carcinoma epidemiology, Colorectal Neoplasms epidemiology, Female, Gene Frequency, Genetic Variation, Genome-Wide Association Study, Humans, Male, Mexico epidemiology, Middle Aged, Polymorphism, Restriction Fragment Length physiology, Polymorphism, Single Nucleotide, Carcinoma genetics, Colorectal Neoplasms genetics, Leptin genetics
Abstract

Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ+45 T/G and +276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and 102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established by PCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differences between CRC patients and control group (p= 0.01 for G/A genotype and p= 0.02 for the recessive model G/G +G/A); yet, in the analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shown any significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients.

Published
2010
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