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La miostatina (MSTN) también conocida como la GDF8, es un regulador negativo del crecimiento del musculo esquelético y responsable del correcto desarrollo de la masa muscular. Su expresión está determinada por muchos mecanismo específicos, por ejemplo dominio de proteínas específicas y genes relacionados. A su vez también, también se obtuvo información acerca de su influencia en determinadas enfermedades que aquejan a nivel de los tejidos musculares como por ejemplo sarcopenia y también relacionándose con el gen FTO (gen de la obesidad). La revisión de la literatura d acerca de la expresión de esta proteína deja en claro que el buen manejo de esta mediante el uso de la Ingeniería Genética, podría ayudar aliviar estos males que debilitan de forma progresiva el sistema esquelético, debilitando el movimiento de las personas.

Copyright of Journal of Sport & Health Research is the property of Journal of Sport & Health Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Iberoamericana de Ciencias de la Actividad Física y el Deporte is the property of Revista Iberoamericana de Ciencias de la Actividad Física y el Deporte and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Investigates spark planed surfaces of pure iron using conversion electron Mössbauer spectroscopy, scanning electron microscopy and x-ray diffraction. Spectra of the low-energy and high-energy sparks; Change in the intensities of the signals associated to each phase; Decomposition of the magnetic signal which arises from iron carbide phases.

We have removed the ZrO layer formed on a Zry sample after heat treatment using a simple process known as abrasive blasting or air impelled glass abrasion. Scanning electron microscopy, energy dispersive spectrometry and optical microscopy were the analysis techniques employed to observe the surface after abrasive blasting and the incorporation of glass spheres on the layer that might produce alterations on the chemical properties of the Zry. [ABSTRACT FROM AUTHOR]

We have studied a prehispanic bronze disc of 366 mm diameter, 3.340 kg, made ca. 500-900 AD from Argentina Northwest, employing metallurgical techniques, SEM and EDS, x-ray radiography and microprobe. We found that this piece was made by melting Cu and Sn in a double matrix. It was found that the piece was well filled but with small bubles coming from the process. Metallography suggested some hammer working near some places of the disc. [ABSTRACT FROM AUTHOR]

ZnS is a useful II-VI compound for optical devices. Due to its strong fluorescence and high resistance to electric fields, it is a material with interesting applications for solar cells, IR windows, lasers and sensors. ZnS has a low excitonic Bohr radius (2.5 nm) so their nanoparticles are appropriate to produce small bio-molecular probes for fluorescence and laser scanning microscopy. Despite progress in the synthesis of the nanocrystalline ZnS many unresolved problems still remain. The origin of the visible luminescence, besides the band gap emission observed in many nanoparticles is still uncertain. In this work, ZnS nanocrystals were obtained by a wet chemical reaction. The reagents used were ZnCl2.2H2O and thiourea respectively for Zn and S. The surfactant agent was 20% tetrametylammonium hydroxide (TMAH) and the solvent was ethylene glycol. The reaction aliquots were collected for various periods of time starting from the onset of the synthesis and redispersed in methanol for optical characterization. The samples were studied by transmission electron microscopy (TEM). The X-ray diffraction (XRD) shows that the crystal has a zinc blend structure and reveals the nanoscale crystals size. TEM micrographs show the presence of large particles of Zn(OH)2 (250 nm) and nanometric particles of ZnS (around 15 nm). The spatial distribution of ZnS particles indicates that spinodal decomposition takes place. The solution therefore separates spontaneously into two phases, starting with small fluctuations and proceeding without a nucleation barrier. [ABSTRACT FROM AUTHOR]

Nano and micrometric spherical iron particles were produced by the spark-erosion method using liquid nitrogen as dielectric. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), standard optical microscopy helped us to find and analyze the spheroidal particles, either hollowed and not with a particular interior and exterior surfaces. No evidences of nitrogen compounds were found. [ABSTRACT FROM AUTHOR]

The debris produced by a waterjet machining equipment was observed and analyzed by optical microscopy, scanning electron microscopy, energy dispersive spectroscopy, backscattered electrons, and transmission electron microscopy. Micro and nano particles of different forms were found as result of the cutting process. [ABSTRACT FROM AUTHOR]

We report characterizations of systems of antiferromagnetic iron oxide particles of importance in catalysis where Mössbauer spectroscopy has played an essential role. We show that signals contributing to the Mössbauer spectra that arise from the surface or from non-crystalline environments still find difficulty in their assignment in spite of the large amount of research already done on hematite and similar antiferromagnetic systems. [ABSTRACT FROM AUTHOR]

We present in this work the effects produced when Zircalloy IV separators for nuclear industry are cut by a waterjet machine with abrasive particles. Residual stresses were observed after the process, while no phase transformations were found. Some abrasive particles appears attached to the surface. [ABSTRACT FROM AUTHOR]

Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects of iron chelation in the tumor microenvironment are unknown. Here, we report that treatment with deferiprone, an FDA-approved iron chelator, unleashes innate immune responses that restrain ovarian cancer. Deferiprone reprogrammed ovarian cancer cells toward an immunostimulatory state characterized by the production of type-I IFN and overexpression of molecules that activate NK cells. Mechanistically, these effects were driven by innate sensing of mitochondrial DNA in the cytosol and concomitant activation of nuclear DNA damage responses triggered upon iron chelation. Deferiprone synergized with chemotherapy and prolonged the survival of mice with ovarian cancer by bolstering type-I IFN responses that drove NK cell-dependent control of metastatic disease. Hence, iron chelation may represent an alternative immunotherapeutic strategy for malignancies that are refractory to current T-cell-centric modalities. Significance: This study uncovers that targeting dysregulated iron accumulation in ovarian tumors represents a major therapeutic opportunity. Iron chelation therapy using an FDA-approved agent causes immunogenic stress responses in ovarian cancer cells that delay metastatic disease progression and enhance the effects of first-line chemotherapy. See related commentary by Bell and Zou, p. 1771., (©2024 American Association for Cancer Research.)

Romaine lettuce outer leaves, as opposed to the more commonly marketed heart, are typically discarded and present an opportunity for upcycling as dried powders. Duquesne Romaine lettuce was evaluated to quantify and compare quality attributes of fresh outer and heart leaves, dried powders following hot air drying, and dried powders following an infrared (IR) blanching pretreatment before drying. Attributes measured for fresh leaves included moisture, water activity (A w ), color, total soluble phenolics (TSP), and antioxidant capacity (AC). Drying kinetics and time/energy saving through IR blanching were evaluated. Attributes measured for dried powders included moisture, A w , color, true density, water vapor isotherms, TSP, AC, cadmium (Cd) content, and pesticide residues. TSP, AC, Cd, and pesticide residues were higher, whereas moisture content and A w were lower in fresh outer versus heart leaves. Hot air drying reduced TSP and AC to 63.6% and 35.2% of fresh values, respectively, whereas IR blanching further reduced TSP and AC to 37.3% and 25.4% in outer leave powders. On the other hand, TSP and AC increased 237% and 151%, respectively, for unblanched heart powders. Higher increase of TSP than AC in heart leaf powder may indicate synthesis of phenolic compounds activated by abiotic stresses such as cutting and high temperatures at the initial drying stage. IR blanching resulted in significant time/energy savings for drying of outer leaves. Microbial loads were substantially reduced during drying, although microbial population on outer leaves were more resistant. Safe to eat outer leaf Romaine lettuce powders can be produced, assuming appropriate agricultural practices., (© 2024 Institute of Food Technologists. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)