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Your search keyword '"Caballin, M.R."' showing total 24 results
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24 results on '"Caballin, M.R."'

10. Translocation yields in peripheral blood lymphocytes from control populations.

Author

Whitehouse, C.A., Edwards, A.A., Tawn, E.J., Stephan, G., Oestreicher, U., Moquet, J.E., Lloyd, D.C., Roy, L., Voisin, P., Lindholm, C., Barquinero, J., Barrios, L., Caballin, M.R., Darroudi, F., and Fomina, J.

Subjects
SMOKING, LYMPHOCYTES, CHROMOSOMAL translocation, CHROMOSOMES, FLUORESCENCE in situ hybridization, DRUG dosage
Abstract

Purpose: To record the latest information on control levels of translocations in cultured human lymphocytes. Materials and methods: Control-level data from seven European laboratories that are using fluorescence in situ hybridization (FISH) techniques for retrospective biological dosimetry have been combined in a meta-analysis. After correction for the differing probe combinations used, tests of consistency are performed. The combined data have been used to test for individual variation, systematic variation with age, gender and smoking habits. Results: There is a strong variation of translocation yield with age but no variation was detectable with gender or smoking habits. After correction for age, homogeneity tests showed that about 10% of individuals were outside the 95% confidence limits as opposed to 5% expected. From a total of 385, there is an excess of about 20 individuals most of whom have an unexpectedly high yield of translocations. Conclusions: For retrospective biological dosimetry purposes a generic age-dependent control level can be assumed. No other lifestyle factors such as smoking appear to have a significant effect on translocation yield. [ABSTRACT FROM AUTHOR]

Published
2005
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11. Human sperm chromosomes.

Author

Templado, C., Benet, J., Genescà, A., Navarro, J., Caballin, M.R., Mirò, R., and Egozcue, J.

Abstract

Sperm chromosome studies have been performed in 70 nor–mal males. The incidence of aneuploidy in this group is ∽ 3−4%, and that of structural anomalies close to 5%. In carriers of reciprocal or Robertsonian translocations, the results are extremely variable, with percentages of unbalanced sperm from 8 to 87÷. No unbalanced spermatozoa have been observed in patients with pericentric or paracentric inver–sions. In cancer patients treated with radio and/or chemotherapy, the incidence of chromosome abnormalities is much higher, and significantly different from that found in controls. [ABSTRACT FROM PUBLISHER]

Published
1988
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