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4 results on '"CUNANNE S."'

3. Short report: Zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease

Author

P. Gionchetti, F. Rizzello, M. Miglioli, S. Cunanne, L. Barbara, Andrea Belluzzi, C. Brignola, S. Boschi, Massimo Campieri, BELLUZZI A., BRIGNOLA C., CAMPIERI M., GIONCHETTI P., RIZZELLO F., BOSCHI S., CUNANNE S., M. MIGLIOLI, and BARBARA L.

Subjects
Adult, Male, medicine.medical_specialty, Erythrocytes, medicine.medical_treatment, Phospholipid, Palmitic Acid, chemistry.chemical_element, Oleic Acids, Zinc, Palmitic Acids, Linoleic Acid, chemistry.chemical_compound, Crohn Disease, Internal medicine, medicine, Humans, Pharmacology (medical), chemistry.chemical_classification, Crohn's disease, Chemotherapy, Arachidonic Acid, Hepatology, business.industry, Sulfates, Fatty Acids, Gastroenterology, Fatty acid, Middle Aged, medicine.disease, Sulfate, Stearic Acid, Zinc Sulfate, Erythrocyte, Red blood cell, Endocrinology, medicine.anatomical_structure, chemistry, Linoleic Acids, Zinc Compounds, Zinc Compound, Composition (visual arts), Female, Long chain fatty acid, business, Stearic Acids, Fatty Acid, Human, Oleic Acid
Abstract

Patients with Crohn's disease may become zinc‐deficient and, in such patients, an altered metabolism of radiolabelled long‐chain fatty acids has been reported. We have investigated the possible reversal by zinc supplementation of altered long‐chain fatty acid profiles of red cells in Crohn's disease. Twenty patients with long‐standing Crohn's disease in clinical remission received 200 mg of zinc sulphate daily for 6 weeks. Phospholipid fatty acid profiles of washed red cells were analysed before and after zinc treatment and compared to those of 20 unsupplemented healthy controls. Plasma zinc levels in Crohn's were 72 ± 8 μg/dL before zinc treatment and increased to 114 ± 10 μg/dl after the therapy. Prior to zinc supplementation, the percentage of palmitic, stearic and oleic acids was significantly higher in Crohn's disease, while linoleic, arachidonic and n‐3 fatty acids were reduced in Crohn's disease compared to healthy controls. Zinc supplementation abolished these pre‐treatment differences in red‐cell long‐chain fatty acid profiles but did not affect plasma fatty acid values. Further studies are needed to clarify whether these fatty acid changes can be related to the clinical course of the disease. Copyright © 1994, Wiley Blackwell. All rights reserved

4. Recognition of white matter bundles using local and global streamline-based registration and clustering.

Author

Garyfallidis E, Côté MA, Rheault F, Sidhu J, Hau J, Petit L, Fortin D, Cunanne S, and Descoteaux M

Subjects
Computer Simulation, Datasets as Topic, Humans, Brain Neoplasms diagnostic imaging, Diffusion Tensor Imaging methods, Image Processing, Computer-Assisted methods, Neuroimaging methods, Pattern Recognition, Automated methods, White Matter diagnostic imaging
Abstract

Virtual dissection of diffusion MRI tractograms is cumbersome and needs extensive knowledge of white matter anatomy. This virtual dissection often requires several inclusion and exclusion regions-of-interest that make it a process that is very hard to reproduce across experts. Having automated tools that can extract white matter bundles for tract-based studies of large numbers of people is of great interest for neuroscience and neurosurgical planning. The purpose of our proposed method, named RecoBundles, is to segment white matter bundles and make virtual dissection easier to perform. This can help explore large tractograms from multiple persons directly in their native space. RecoBundles leverages latest state-of-the-art streamline-based registration and clustering to recognize and extract bundles using prior bundle models. RecoBundles uses bundle models as shape priors for detecting similar streamlines and bundles in tractograms. RecoBundles is 100% streamline-based, is efficient to work with millions of streamlines and, most importantly, is robust and adaptive to incomplete data and bundles with missing components. It is also robust to pathological brains with tumors and deformations. We evaluated our results using multiple bundles and showed that RecoBundles is in good agreement with the neuroanatomical experts and generally produced more dense bundles. Across all the different experiments reported in this paper, RecoBundles was able to identify the core parts of the bundles, independently from tractography type (deterministic or probabilistic) or size. Thus, RecoBundles can be a valuable method for exploring tractograms and facilitating tractometry studies., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2018
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