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7. Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial

Author

HAG Trombose, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTM & Statistical consultation, Cancer, MS Geriatrie, Circulatory Health, Directie Raad van Bestuur, HAG Hart- Vaatziekten, Joosten, Linda P T, van Doorn, Sander, van de Ven, Peter M, Köhlen, Bart T G, Nierman, Melchior C, Koek, Huiberdina L, Hemels, Martin E W, Huisman, Menno V, Kruip, Marieke, Faber, Laura M, Wiersma, Nynke M, Buding, Wim F, Fijnheer, Rob, Adriaansen, Henk J, Roes, Kit C, Hoes, Arno W, Rutten, Frans H, Geersing, Geert-Jan, HAG Trombose, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTM & Statistical consultation, Cancer, MS Geriatrie, Circulatory Health, Directie Raad van Bestuur, HAG Hart- Vaatziekten, Joosten, Linda P T, van Doorn, Sander, van de Ven, Peter M, Köhlen, Bart T G, Nierman, Melchior C, Koek, Huiberdina L, Hemels, Martin E W, Huisman, Menno V, Kruip, Marieke, Faber, Laura M, Wiersma, Nynke M, Buding, Wim F, Fijnheer, Rob, Adriaansen, Henk J, Roes, Kit C, Hoes, Arno W, Rutten, Frans H, and Geersing, Geert-Jan

Published
2024

8. Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer: A Randomized Clinical Trial

Author

Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiotherapie, Mink van der Molen, Dieuwke R, Batenburg, Marilot C T, Maarse, Wiesje, van den Bongard, Desiree H J G, Doeksen, Annemiek, de Lange, Marjoleine Y, van der Pol, Carmen C, Evers, Daniel J, Lansdorp, Corine A, van der Laan, Jacco, van de Ven, Peter M, van der Leij, Femke, Verkooijen, Helena M, Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiotherapie, Mink van der Molen, Dieuwke R, Batenburg, Marilot C T, Maarse, Wiesje, van den Bongard, Desiree H J G, Doeksen, Annemiek, de Lange, Marjoleine Y, van der Pol, Carmen C, Evers, Daniel J, Lansdorp, Corine A, van der Laan, Jacco, van de Ven, Peter M, van der Leij, Femke, and Verkooijen, Helena M

Published
2024

9. Anatomical Markers Associated With the Presence of Intracranial Aneurysms in Individuals Screened for Aneurysms

Author

Cancer, Beeldverwerking ISI, Highfield Research Group, Brain, Opleiding Neurologie, Other research (not in main researchprogram), CTM & Statistical consultation, Neurologen, Circulatory Health, Structure and Connections, Regenerative Medicine and Stem Cells, MS Radiologie, Researchgr. Hart-brein as., Vos, Iris, van Tuijl, Rick, Mensing, Liselore, Ophelders, Maud, Velthuis, Mireille, Zuithoff, Peter, Rinkel, GJE, Kuijf, Hugo, Zwanenburg, JJM, van der Schaaf, Irene, Velthuis, Birgitta, Ruigrok, YM, Cancer, Beeldverwerking ISI, Highfield Research Group, Brain, Opleiding Neurologie, Other research (not in main researchprogram), CTM & Statistical consultation, Neurologen, Circulatory Health, Structure and Connections, Regenerative Medicine and Stem Cells, MS Radiologie, Researchgr. Hart-brein as., Vos, Iris, van Tuijl, Rick, Mensing, Liselore, Ophelders, Maud, Velthuis, Mireille, Zuithoff, Peter, Rinkel, GJE, Kuijf, Hugo, Zwanenburg, JJM, van der Schaaf, Irene, Velthuis, Birgitta, and Ruigrok, YM

Published
2024

10. A compact single radiator CRLH-inspired circularly polarized leaky-wave antenna based on substrate-integrated waveguide

Author

Lee, H, Choi, JH, Wu, CTM, and Itoh, T

Subjects
Circular polarization, composite right/left handed, leaky-wave antenna, substrate-integrated waveguide, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies
Abstract

A circularly polarized (CP) CRLH-inspired leaky-wave antenna (LWA) based on substrate-integrated waveguide (SIW) and microstrip delay line is presented. The unit-cell of the proposed periodic antenna consists of two conventional CRLH SIW cells and two quarter-wavelength microstrip lines. The interdigital slots on the CRLH SIW are rotated at +45° and -45° with respect to the wave propagation direction and separated by 90° to create circular polarization. Utilizing the microstrip line instead of the SIW delay section, the total size of the five unit-cell antenna is reduced by 24.4% in comparison to the previous single radiator CP LWA. Furthermore, microstrip lines provide improved matching for broadside radiation as well as better CP purity. The unitcell characteristics are investigated in detail through dispersion and Bloch impedance analysis. In addition, space harmonic analysis is carried out to explain the radiation mechanism of the proposed antenna. The proposed CRLH-inspired SIW CP antenna operates from 4.2 to 4.85 GHz and frequency scans from -25° to 26° along the elevation angle. Axial ratio is maintained below 3 dB throughout the operating frequency. The measured results show good agreement with the simulated results.

Published
2015

11. Magnetic-current-loop-induced electric dipole antenna based on substrate integrated waveguide cavity

Author

Wu, CTM, Choi, JH, Lee, H, and Itoh, T

Subjects
Annular ring, antenna array, dipole antenna, magnetic current, substrate integrated waveguide, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies
Abstract

In this letter, a novel dipole antenna based on substrate integrated waveguides (SIWs) is presented. The dipole antenna radiates through the equivalent magnetic current loops on the top and bottom annular ring slot that is excited by the fundamental mode of the SIW cavity. Therefore, the proposed dipole possesses a vertical polarization perpendicular to the metallic plane. Moreover, thanks to normal electric field, the proposed dipole is less affected by the ground plane size and surrounding metal. The proposed antenna topology provides a very easy way to realize vertical dipole antenna by just using planar circuits and is promising to be used as a fundamental element to realize antenna arrays. © 2002-2011 IEEE.

Published
2014

12. Maximally flat negative group-delay circuit: A microwave transversal filter approach

Author

Wu, CTM and Itoh, T

Subjects
Anomalous dispersion, directional couplers, dispersion engineering, distributed amplifiers, negative group delay, transversal filters, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies
Abstract

A comprehensive method to synthesize negative group delay (NGD) in the microwave regime with a maximally flat response is proposed in this paper. This method is based on transversal-filter topologies; it will be shown that by choosing proper coupling coefficients of each tap of a transversal filter, we can realize NGDs with maximally flat characteristics at the output of the transversal filter. The desired coefficients to realize maximally flat NGDs with various amount of group delay are analytically derived and tabulated in this paper. Furthermore, the results are verified experimentally through microwave transversal-filter approaches in both passive and active ways using multi-section asymmetric directional couplers and distributed amplifiers. © 1963-2012 IEEE.

Published
2014

13. Study and analysis of contiguous channel triplexer based on combining method of two filtering circuits using CRLH and RH isolation circuits

Author

Lee, H, Wu, CTM, and Itoh, T

Subjects
Passive Components and Circuits, Meta-materials and Photonic Bandgap Structures
Abstract

Several types of multiplexers based on isolation circuits have been introduced and investigated. Combining method of two filtering circuits (CMTC) is one way to make multiplexers based on isolation circuits. This method fits well for designing contiguous channel triplexers. A triplexer based on CMTC consists of a conventional transmission line (TL) connected to a diplexer and a composite right/left-handed (CRLH) TL connected to a filter. The triplexer based on CMTC has two significant advantages. One is that it is not necessary to modify the design of a stand-alone filter and diplexer and there is freedom in the choice of filtering circuits. In addition, a designer does not need to perform three-dimensional full-wave optimization, because of a simple and straightforward design concept. In this paper, a triplexer prototype having 1, 1.125, and 1.25 GHz center frequencies, is designed and fabricated. The measured results show good agreement with the simulation results. © Cambridge University Press and the European Microwave Association 2014.

Published
2014

14. A dual-purpose reconfigurable negative group delay circuit based on distributed amplifiers

Author

Wu, CTM, Gharavi, S, Daneshrad, B, and Itoh, T

Subjects
Dispersion engineering, distributed amplifier, dynamic power supply, negative group delay, superluminal group velocity, transversal filter, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies, Optical Physics
Abstract

In this letter, a novel reconfigurable negative group delay distributed amplifier (NGD-DA) circuit is proposed. This NGD-DA offers a new method to realize negative group delay. By properly choosing the gain coefficient of each tap for the DA, we can synthesize the negative group delay at the reverse port of the DA in the frequency band of interest, while maintaining a flat gain at the forward port; this results in a dual-purpose DA. Moreover, the proposed NGD-DA is reconfigurable; the phase response at the reverse port can be simply controlled by adjusting the tap gain coefficients, and therefore the bandwidth as well as the amount of negative group delay can be manipulated. The proposed active NGD circuit is validated through theoretical explanation and experimental results. © 2013 IEEE.

Published
2013

15. Voedselverkooppunten in beeld. Een inventarisatie van mogelijke indicatoren en databronnen

Author

RE Vellinga, EAP Martens, and CTM van Rossum

Subjects
RIVM rapport 2023-0244
Abstract

De voedselomgeving bepaalt voor een groot deel wat mensen kopen, en dus of mensen gezond of ongezond eten. De voedselomgeving is alles wat kan bepalen wat we eten: van aanbod, prijzen, aanbiedingen, informatie en verkooppunten, tot sociale normen, culturele eetgewoonten en wettelijke afspraken. Ongezonde voeding vergroot de kans op overgewicht en chronische ziekten als hart- en vaatziekten en diabetes type 2. De Nederlandse overheid werkt daarom aan een voedselomgeving die mensen helpt om gezondere keuzes te maken. Om beleid te kunnen maken, is inzicht nodig in de verschillende onderdelen van de voedselomgeving. Het ministerie van VWS(Ministerie van Volksgezondheid, Welzijn en Sport ) wil daarom onder andere inventariseren hoe de verkooppunten van voedsel in kaart kunnen worden gebracht. Hieronder vallen alle verkooppunten van alle soorten voedsel, dus van groenteboer en supermarkt tot restaurant en snackbar. Het RIVM geeft voorbeelden hoe de verkooppunten in kaart kunnen worden gebracht (indicatoren) en welke informatie (databronnen) hierover in Nederland beschikbaar is. De twee belangrijkste indicatoren zijn: de ‘dichtheid’ en ‘nabijheid’ van verkooppunten. Met dichtheid bedoelen we hoeveel verkooppunten er in een bepaald gebied zijn, bijvoorbeeld hoeveel verkooppunten in een wijk. Bij nabijheid gaat het erom hoe ver een verkooppunt ligt van bijvoorbeeld een school of woonwijk. Om te kunnen bepalen welke indicatoren en databronnen te gebruiken zijn, moet eerst het doel van de monitor van de hele voedselomgeving duidelijk worden. Zo moet worden bepaald of de monitor nodig is om beleid over de voedselomgeving op landelijk niveau te ontwikkelen. Of juist om beleid over specifieke vraagstukken voor een gemeente te evalueren. Ook kan de mate waarin het voedselaanbod gezond en duurzaam is onderdeel van de monitor zijn. Het monitoren van de verkooppunten kan onderdeel zijn van een brede monitor van de voedselomgeving.

Published
2023

16. Disparities in access to ear and hearing care in Cambodia: a mixed methods study on patient experiences

Author

Waterworth, CJ, Watters, CTM, Sokdavy, T, Annear, PL, Dowell, R, Grimes, CE, Bhutta, MF, Waterworth, CJ, Watters, CTM, Sokdavy, T, Annear, PL, Dowell, R, Grimes, CE, and Bhutta, MF

Abstract

OBJECTIVE: Chronic suppurative otitis media is a major global disease disproportionately affecting low- and middle-income countries, but few studies have explored access to care for those with ear and hearing disorders. METHOD: In a tertiary hospital in Cambodia providing specialist ear services, a mixed method study was undertaken. This study had three arms: (1) quantitative analysis of patients undergoing ear surgery, (2) a questionnaire survey and (3) semi-structured in-depth interviews. RESULTS: Patients presented with advanced middle-ear disease and associated hearing loss at rates that are amongst the highest per capita levels globally. Patients reported several structural, financial and socio-cultural barriers to treatment. This study showed a significant burden of ear disease in Cambodia, which reflects a delay in receiving timely and effective treatment. CONCLUSION: This study highlights the opportunity to integrate effective ear and hearing care into primary care service provision, strengthening the package of activities delivered at government facilities.

Published
2023

17. The diet of the Dutch. Results of the Dutch National Food Consumption Survey 2019- 2021 on food consumption and evaluation with dietary guidelines

Author

van Rossum, CTM, Sanderman-Nawijn, EL, Brants, HAM, Dinnissen, CS, Jansen-van der Vliet, M, Beukers, MH, Ockë, MC, van Rossum, CTM, Sanderman-Nawijn, EL, Brants, HAM, Dinnissen, CS, Jansen-van der Vliet, M, Beukers, MH, and Ockë, MC

Abstract

RIVM rapport:The Dutch National Food Consumption Survey (DNFCS) 2019-2021 shows what Dutch people eat and drink, and how much. The DNFCS also shows the level of adherence to the Dutch dietary guidelines and changes to this level since the previous surveys in 2012-2016 and 2007- 2010. In recent years, the Dutch have been eating more healthily. One of the reasons for this is that they have been eating more vegetable products, such as vegetables, fruit, unsalted nuts and legumes. At the same time, they have been consuming less red and/or processed meat and sugarcontaining beverages. Most improvements are apparent in both adults and children. People have also been using more dietary supplements, including supplements with vitamin D. In spite of this, the diets of most Dutch people do not comply with the Dutch dietary guidelines. Generally speaking, the diets of women, those aged over 65 and those educated to a higher level follow the Dutch dietary guidelines more closely than the diets of men, young adults and those with a lower level of education. These guidelines form the basis for the Netherlands Nutrition Centre’s Wheel of Five. A healthier diet can help prevent overweight and chronic diseases, such as cardiovascular disease. For this edition of the survey, RIVM researched the diets of over 3,500 children and adults. The data make it possible for policymakers and professionals to continue their work on the development of healthy and sustainable diets, product innovation, education and research. This report describes and discusses the survey method and results in detail. It is intended for a target audience of national and international scientists and professionals. The results are available on www.wateetnederland.nl. Results on the quantities of nutrients that the Dutch ingest will be published later in 2023., De Nationale Voedselconsumptiepeiling 2019-2021 (VCP(Voedselconsumptiepeiling)) laat zien hoeveel en wat mensen in Nederland eten en drinken. De VCP maakt ook duidelijk of zij de richtlijnen Goede voeding volgen en wat daarin is veranderd sinds de vorige peilingen in 2012-2016 en 2007-2010. De afgelopen jaren zijn Nederlanders gezonder gaan eten. Dat komt onder andere omdat ze meer plantaardige producten zoals groente, fruit, ongezouten noten en peulvruchten eten. Ook eten ze minder rood en bewerkt vlees en drinken ze minder suikerhoudende dranken. De meeste verbeteringen zijn te zien bij zowel de volwassenen als de kinderen. Verder zijn mensen meer voedingssupplementen gaan gebruiken, zoals vitamine D. Toch eten de meeste Nederlanders niet volgens de Richtlijnen Goede voeding. Over het algemeen volgen vrouwen, 65-plussers en hoger opgeleiden beter de Richtlijnen voor gezonde voeding dan mannen, jongvolwassenen en lager opgeleiden. Deze richtlijnen zijn de basis voor de Schijf van Vijf van het Voedingscentrum. Een gezondere voeding kan helpen om overgewicht en chronische ziekten als hart- en vaatziekten te voorkomen. Het RIVM bracht dit keer het voedingspatroon met ruim 3500 kinderen en volwassenen in kaart. Met deze gegevens kunnen beleidsmakers en professionals werken aan een gezond en duurzaam voedingspatroon, productinnovatie, voorlichting en onderzoek. Dit rapport beschrijft en bediscussieert de onderzoeksmethode en resultaten in detail. Het is bedoeld voor (inter)nationale wetenschappers en professionals. De resultaten zijn eerder al gepubliceerd op www.wateetnederland.nl(externe link). De resultaten over hoeveel voedingsstoffen mensen binnenkrijgen verschijnen later in 2023.

Published
2023

18. Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trial

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), CTI Leusen, Cancer, CTM & Statistical consultation, CTI Research, CTI Bont, Child Health, Infectiezieken, Longziekten patientenzorg, Arts-assistenten Kinderen, MS Neonatologie, PMC Medisch specialisten, Brain, Regenerative Medicine and Stem Cells, MMB Medische Staf, Narsyn Study Group, Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), CTI Leusen, Cancer, CTM & Statistical consultation, CTI Research, CTI Bont, Child Health, Infectiezieken, Longziekten patientenzorg, Arts-assistenten Kinderen, MS Neonatologie, PMC Medisch specialisten, Brain, Regenerative Medicine and Stem Cells, MMB Medische Staf, and Narsyn Study Group

Published
2023

19. Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial

Author

Opleiding Neurologie, Projectafdeling CVZ, MMB opleiding Arts microbioloog, Infection & Immunity, MS Radiologie, Brain, Circulatory Health, CTM & Statistical consultation, Translational Neuroscience, Cancer, Neurologen, Koopman, Inez, Tack, Reinier Wp, Wunderink, Herman F, Bruns, Anke Hw, van der Schaaf, Irene C, Cianci, Daniela, Gelderman, Kyra A, van de Ridder, Inge M, Hol, Elly M, Rinkel, Gabriel Je, Vergouwen, Mervyn DI, Opleiding Neurologie, Projectafdeling CVZ, MMB opleiding Arts microbioloog, Infection & Immunity, MS Radiologie, Brain, Circulatory Health, CTM & Statistical consultation, Translational Neuroscience, Cancer, Neurologen, Koopman, Inez, Tack, Reinier Wp, Wunderink, Herman F, Bruns, Anke Hw, van der Schaaf, Irene C, Cianci, Daniela, Gelderman, Kyra A, van de Ridder, Inge M, Hol, Elly M, Rinkel, Gabriel Je, and Vergouwen, Mervyn DI

Published
2023

21. COVID-19 Vaccine Safety Monitoring Studies in Low- and Middle-Income Countries (LMICs)-A Systematic Review of Study Designs and Methods

Author

Data Science & Biostatistiek, RWE/Causal inference, Child Health, CTM & Statistical consultation, Cancer, Sisay, Malede Mequanent, Montesinos-Guevara, Camila, Osman, Alhadi Khogali, Saraswati, Putri Widi, Tilahun, Binyam, Ayele, Tadesse Awoke, Ahmadizar, Fariba, Durán, Carlos E, Sturkenboom, Miriam C J M, van de Ven, Peter, Weibel, Daniel, Data Science & Biostatistiek, RWE/Causal inference, Child Health, CTM & Statistical consultation, Cancer, Sisay, Malede Mequanent, Montesinos-Guevara, Camila, Osman, Alhadi Khogali, Saraswati, Putri Widi, Tilahun, Binyam, Ayele, Tadesse Awoke, Ahmadizar, Fariba, Durán, Carlos E, Sturkenboom, Miriam C J M, van de Ven, Peter, and Weibel, Daniel

Published
2023

22. The RISE study protocol: resilience impacted by positive stressful events for people with cystic fibrosis

Author

Longziekten onderzoek 1, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Sociale Pediatrie patientenzorg, van der Heijden, Els, van den Bor, Rutger M, van der Ent, Cornelis K, Nijhof, Sanne L, van der Laan, Sabine E I, Longziekten onderzoek 1, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Sociale Pediatrie patientenzorg, van der Heijden, Els, van den Bor, Rutger M, van der Ent, Cornelis K, Nijhof, Sanne L, and van der Laan, Sabine E I

Published
2023

23. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study)

Author

MS Medische Oncologie, CTM & Statistical consultation, Cancer, HEE, Kistemaker, K. R.J., de Graeff, A., Crul, M., de Klerk, G., van de Ven, P. M., van der Meulen, M. P., van Zuylen, L., Steegers, M. A.H., MS Medische Oncologie, CTM & Statistical consultation, Cancer, HEE, Kistemaker, K. R.J., de Graeff, A., Crul, M., de Klerk, G., van de Ven, P. M., van der Meulen, M. P., van Zuylen, L., and Steegers, M. A.H.

Published
2023

24. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study

Author

Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, CTI Bont, RESCEU Investigators, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, CTI Bont, and RESCEU Investigators

Published
2023

25. Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, Endocrinologie onderzoek, Cancer, MS Orthopaedie Algemeen, CTM & Statistical consultation, CTI Bont, Child Health, RSV GOLD Study Group, Infectieziekten onderzoek1 (Bont), Infection & Immunity, Endocrinologie onderzoek, Cancer, MS Orthopaedie Algemeen, CTM & Statistical consultation, CTI Bont, Child Health, and RSV GOLD Study Group

Published
2023

26. Global impacts of COVID-19 on lifestyles and health and preparation preferences: An international survey of 30 countries.

Author

Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Man Ho, M, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, Youssef, N, Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Man Ho, M, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, and Youssef, N

Abstract

BACKGROUND: The health area being greatest impacted by coronavirus disease 2019 (COVID-19) and residents' perspective to better prepare for future pandemic remain unknown. We aimed to assess and make cross-country and cross-region comparisons of the global impacts of COVID-19 and preparation preferences of pandemic. METHODS: We recruited adults in 30 countries covering all World Health Organization (WHO) regions from July 2020 to August 2021. 5 Likert-point scales were used to measure their perceived change in 32 aspects due to COVID-19 (-2 = substantially reduced to 2 = substantially increased) and perceived importance of 13 preparations (1 = not important to 5 = extremely important). Samples were stratified by age and gender in the corresponding countries. Multidimensional preference analysis displays disparities between 30 countries, WHO regions, economic development levels, and COVID-19 severity levels. RESULTS: 16 512 adults participated, with 10 351 females. Among 32 aspects of impact, the most affected were having a meal at home (mean (m) = 0.84, standard error (SE) = 0.01), cooking at home (m = 0.78, SE = 0.01), social activities (m = -0.68, SE = 0.01), duration of screen time (m = 0.67, SE = 0.01), and duration of sitting (m = 0.59, SE = 0.01). Alcohol (m = -0.36, SE = 0.01) and tobacco (m = -0.38, SE = 0.01) consumption declined moderately. Among 13 preparations, respondents rated medicine delivery (m = 3.50, SE = 0.01), getting prescribed medicine in a hospital visit / follow-up in a community pharmacy (m = 3.37, SE = 0.01), and online shopping (m = 3.33, SE = 0.02) as the most important. The multidimensional preference analysis showed the European Region, Region of the Americas, Western Pacific Region and countries with a high-income level or medium to high COVID-19 severity were more adversely impacted on sitting and screen time duration and social activities, whereas other regions and countries experienced more cooking and eating at home. Countries wit

Published
2023

27. Key lifestyles and interim health outcomes for effective interventions in general populations: A network analysis of a large international observational study.

Author

Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Ho, MM, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, Youssef, N, Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Ho, MM, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, and Youssef, N

Abstract

BACKGROUND: The interconnected nature of lifestyles and interim health outcomes implies the presence of the central lifestyle, central interim health outcome and bridge lifestyle, which are yet to be determined. Modifying these factors holds immense potential for substantial positive changes across all aspects of health and lifestyles. We aimed to identify these factors from a pool of 18 lifestyle factors and 13 interim health outcomes while investigating potential gender and occupation differences. METHODS: An international cross-sectional study was conducted in 30 countries across six World Health Organization regions from July 2020 to August 2021, with 16 512 adults self-reporting changes in 18 lifestyle factors and 13 interim health outcomes since the pandemic. RESULTS: Three networks were computed and tested. The central variables decided by the expected influence centrality were consumption of fruits and vegetables (centrality = 0.98) jointly with less sugary drinks (centrality = 0.93) in the lifestyles network; and quality of life (centrality = 1.00) co-dominant (centrality = 1.00) with less emotional distress in the interim health outcomes network. The overall amount of exercise had the highest bridge expected influence centrality in the bridge network (centrality = 0.51). No significant differences were found in the network global strength or the centrality of the aforementioned key variables within each network between males and females or health workers and non-health workers (all P-values >0.05 after Holm-Bonferroni correction). CONCLUSIONS: Consumption of fruits and vegetables, sugary drinks, quality of life, emotional distress, and the overall amount of exercise are key intervention components for improving overall lifestyle, overall health and overall health via lifestyle in the general population, respectively. Although modifications are needed for all aspects of lifestyle and interim health outcomes, a larger allocation of resources and more intensi

Published
2023

28. Characterization and Storage Stability Study of Guava and Mango Wood Smoked Induced Spiced Cultured Milk (Raita)

Author

Arghya Chaudhuri, null Aditya, Himanshu Mishra, Sachin Patidar, Hameedur Rehman, Lokesh Choudhary, and CTM Kumar

Abstract

A study was conducted to evaluate the effect of the smoking of raita with guava and mango wood on its functional properties and storage stability. The raita was smoked with guava and mango wood for 2.5, 5, 7.5, and 10 min in a closed chamber. The smoked raita was evaluated for change in titratable acidity (TA), pH, total phenolic content (TPC), antioxidant activity (DPPH), colour (L*, a*, and b*), and sensory attributes. Both guava and mango wood smoked samples didn’t show significant changes (P

Published
2022

31. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries

Author

Alia, DB, Tandili, A, Paiva, L, Wime, AD, Chantada, GL, Fandino, AC, Sgroi, M, Papyan, R, Tamamyan, G, Camuglia, JE, Gole, GA, Clark, A, Lam, GC, Elder, JE, McKenzie, JD, Staffieri, SE, Jones, MM, Manudhane, R, Sia, D, Ritter-Sovinz, P, Schwab, C, Balayeva, R, Khan, Z, Nuruddin, M, Roy, SR, Rashid, R, Sultana, S, Shakoor, SA, Naumenko, L, Zhilyaeva, K, Bartoszek, P, Brichard, BG, De Potter, P, Bio, AIA, Salas, B, Coleoni Suarez, ME, Mbumba, FB, Bonanomi, MTBC, Donato Macedo, CR, Grigorovski, NDAK, Mattosinho, CCDS, Teixeira, LF, Oscar, AH, Veleva-Krasteva, NV, Bouda, GC, Kabore, RL, Philbert, R, Evina, TGA, Nkumbe, HE, Kamsang, P, Muyen, OM, Dimaras, H, Mallipatna, A, Hamel, P, Superstein, R, Paton, KE, Strahlendorf, C, Palet, JEKK, Tyau-Tyau, H, Cavieres, I, Lopez, JP, Oporto, J, Ossandon, D, Chen, W, Xiang, D, Du, Y, Li, K, Ji, X, Tang, J, Li, C, Xu, B, Qian, J, Xue, K, Sun, X, Wang, Y-Z, Zhang, Y, Wu, S-Q, Xiao, Y, Yang, H, Ye, H, Polania, RA, Berete, RC, Couitchere, L, Peric, S, Alemany-Rubio, E, Gonzalez-Rodriguez, L, Autrata, R, Kepak, T, Pochop, P, Svojgr, K, Gregersen, PA, Urbak, SF, Montero, MM, Budiongo, A, Yanga, JM, Amani, TBK, Lukamba, RM, Numbi, MN, Calle Jara, DA, Villacis Chafla, EG, Sanchez, GL, Abouelnaga, S, Afifi, MA, Elhaddad, AM, Ali, AM, Elzembely, M, Said, AMA, Ziko, OAO, Fuentes-Alabi, SL, Goenz, MA, Eerme, K, Klett, A, Hordofa, DF, Mengesha, AA, Sherief, ST, Kivela, TT, Nummi, K, Cassoux, N, Desjardins, L, Obono-Obiang, G, Kardava, T, Khotenashvili, Z, Bechrakis, NE, Biewald, EM, Schlueter, S, Ketteler, P, Amankwaa-Frempong, D, Essuman, VA, Paintsil, V, Renner, LA, Alejos, A, Giron, A, Carreras, YA, Fu, LD, Maldonado, C, Wong, ES, Yam, JC, Csoka, M, Maka, E, Aggarwal, P, Gupta, V, Bhaduri, A, Bhattacharyya, A, Das, A, Chawla, B, Das, P, Das, S, Gupta, H, Gupta, S, Verma, N, Kaliki, S, Khetan, V, Maitra, P, Mahajan, A, Menon, V, Mishra, DKC, Palanivelu, MS, Ramanjulu, R, Mudaliar, SS, Nair, AG, Natarajan, S, Seth, R, Singh, U, Bhat, S, Dudeja, G, Tripathy, D, Akib, IMNR, Pagarra, H, Amiruddin, PO, Kuntorini, MW, Armytasari, I, Supriyadi, E, Sutyawan, IWE, Yuliawati, P, Lutfi, D, Soebagjo, HD, Rahman, A, Sitorus, RS, Victor, AA, Tehuteru, ES, Widiarti, W, Nency, YM, Faranoush, M, Mehrvar, A, Tashvighi, M, Sedaghat, A, Ghassemi, F, Khodabande, A, Abdulqader, RA, Al-Shaheen, AASM, Al Ani, MH, Haydar, H, Al-Badri, SAF, Al-Jadiry, MF, Sabhan, AH, Al-Jumaily, U, Al-Mafrachi, AARM, Al-Shammary, EH, Al-Janabi, ANH, Qadir, AO, Capra, M, Blum, S, Gomel, N, Fabian, ID, Goldberg, H, Kapelushnik, N, Madgar, S, Vishnevskia-Dai, V, Frenkel, S, Pe'er, J, Gorfine, M, Refaeli, D, Steinberg, DM, Lavy, Y, Toledano, H, Caspi, S, De Francesco, S, Hadjistilianou, T, Ida, R, Valente, P, Midena, E, Parrozzani, R, Cowan-Lyn, KE, Vaughan, LO, Suzuki, S, Mohammad, MT, Yousef, YA, Manzhuova, L, Atsiaya, R, Matende, IO, Begimkulova, AS, Makimbetov, EK, Keomisy, J, Sayalith, P, Valeina, S, Viksnins, M, Al-Haddad, CE, Saab, RH, Alsawidi, KM, Elbahi, AM, Krivaitiene, D, Tateshi, B, Randrianarisoa, HL, Raobela, L, Msukwa, G, Nyirenda, C, Hamzah, N, Teh, KH, Sylla, F, Traore, F, Cheikh, SS, Zein, E, Perez, GG, Sanchez Orozco, AJ, Ortega-Hernandez, M, Ramirez-Ortiz, MA, Chuluunbat, T, Abdallah, E, Benmiloud, S, El Kettani, A, Hessissen, L, Almeida, AA, Limbu, B, Rajkarnikar, P, Saiju, R, Moll, AC, Wijsard, MVH, Cockcroft, RL, Ng, Y, Dodgshun, AJ, Calderon-Sotelo, P, Abdullahi, SU, Hassan, S, Umar, AB, Abdulrahaman, AA, Wali, AH, Ademola-Popoola, DS, Adio, A, Aghaji, AE, Ezegwui, IR, Akinsete, A, Musa, KO, Fasina, O, Ibanga, A, Nkanga, ED, Mustapha, T, Ribadu, D, Hummelen, M, Ahmad, A, Mushtaq, A, Qayyum, S, Chaudhry, S, Fadoo, Z, Jeeva, I, Masud, S, Hamid, SA, Zia, N, Siddiqui, SN, Janjua, T, Yaqub, MA, Khaqan, HA, Quintero D, K, Yee, R, Jairaj, V, Cano, MR, Fernandez, DDPG, Diaz Coronado, RY, Zapata Lopez, AM, Garcia, JL, Ponce, J, Garcia Pacheco, HN, Pascual Morales, CR, Vasquez Anchaya, JK, Tarrillo Leiva, FF, Alcasabas, APA, Mercado, GJ, Cieslik, K, Hautz, W, Rogowska, A, Castela, G, Silva, S, Jo, DH, Kim, JH, Comsa, C, Dragomir, MD, Neroev, V, Saakyan, S, Polyakov, V, Ushakova, TL, Yarovaya, VA, Yarovoy, AA, Theophile, T, Al Mesfer, S, Maktabi, A, Al-Dahmash, SA, Alkatan, HM, Moreira, C, Roth, PAN, Ilic, VR, Nikitovic, M, Latinovic, S, Quah, B, Tan, D, Hederova, S, Husakova, K, Groznik, AL, Pompe, MT, Davidson, A, Du Bruyn, M, Du Plessis, J, Stones, DK, Geel, JA, Myezo, KH, Kruger, M, Mayet, I, Naidu, G, Naidu, N, Mustak, H, Reynders, D, Wetter, J, Alarcon Portabella, S, Martin-Begue, N, Wolley Dod, C, Balaguer, J, Barranco, H, Catala-Mora, J, Correa Llano, MG, Fernandez-Teijeiro, A, Garcia Aldana, D, Peralta Calvo, J, San Roman Pacheco, S, Gunasekera, DS, Elhassan, MMA, Mohamedani, AA, All-Eriksson, C, Bartuma, K, Popovic, MB, Munier, FL, Liu, C-H, Chiwanga, FS, Kyara, A, Mndeme, FG, Msina, MS, Scanlan, TA, Atchaneeyasakul, L-O, Buaboonnam, J, Dangboon, W, Singha, P, Hongeng, S, Kulvichit, K, Rojanaporn, D, Surukrattanaskul, S, Wangtiraumnuay, N, Wiwatwongwana, A, Wiwatwongwana, D, Wongwai, P, Sharma, MK, Guedenon, KM, Bouguila, H, Atalay, HT, Hasanreisoglu, M, Ataseven, E, Kantar, M, Gunduz, AK, Kebudi, R, Kiratli, H, Koc, I, Tuncer, S, Unal, E, Kalinaki, A, Matua, M, Waddell, K, Musika, AA, Ssali, G, Al Harby, L, Reddy, MA, Astbury, NJ, Bascaran, C, Bowman, R, Burton, MJ, Foster, A, Zondervan, M, Sagoo, MS, Bobrova, N, Sorochynska, T, Lysytsia, L, Castillo, L, Afshar, AR, Berry, JL, Kim, JW, Randhawa, JK, Binkley, E, Boldt, HC, Larson, SA, Brennan, RC, Chandramohan, A, Stacey, AW, Corson, TW, Plager, DA, Davanzo, JM, Singh, AD, Demirci, H, Ericksen, C, Magrath, GN, Gold, AS, Murray, TG, Gonzalez, E, Shah, AS, Hansen, ED, Hartnett, ME, Harbour, JW, Hubbard, GB, Uner, OE, Laurenti, KD, Mets, MB, Leverant, AA, Ramasubramanian, A, Luna-Fineman, S, Miller, A, Skalet, AH, Mruthyunjaya, P, Hassan, M, Oliver, SC, Shields, CL, Yaghy, A, Stahl, ED, Wilson, MW, Villegas, VM, Islamov, Z, Usmanov, RH, Graells, J, Romero, L, Pham, CTM, Trang, DL, Al-Hussaini, HH, Thawaba, ADM, Muma, KIM, Nyaywa, M, Alia, DB, Tandili, A, Paiva, L, Wime, AD, Chantada, GL, Fandino, AC, Sgroi, M, Papyan, R, Tamamyan, G, Camuglia, JE, Gole, GA, Clark, A, Lam, GC, Elder, JE, McKenzie, JD, Staffieri, SE, Jones, MM, Manudhane, R, Sia, D, Ritter-Sovinz, P, Schwab, C, Balayeva, R, Khan, Z, Nuruddin, M, Roy, SR, Rashid, R, Sultana, S, Shakoor, SA, Naumenko, L, Zhilyaeva, K, Bartoszek, P, Brichard, BG, De Potter, P, Bio, AIA, Salas, B, Coleoni Suarez, ME, Mbumba, FB, Bonanomi, MTBC, Donato Macedo, CR, Grigorovski, NDAK, Mattosinho, CCDS, Teixeira, LF, Oscar, AH, Veleva-Krasteva, NV, Bouda, GC, Kabore, RL, Philbert, R, Evina, TGA, Nkumbe, HE, Kamsang, P, Muyen, OM, Dimaras, H, Mallipatna, A, Hamel, P, Superstein, R, Paton, KE, Strahlendorf, C, Palet, JEKK, Tyau-Tyau, H, Cavieres, I, Lopez, JP, Oporto, J, Ossandon, D, Chen, W, Xiang, D, Du, Y, Li, K, Ji, X, Tang, J, Li, C, Xu, B, Qian, J, Xue, K, Sun, X, Wang, Y-Z, Zhang, Y, Wu, S-Q, Xiao, Y, Yang, H, Ye, H, Polania, RA, Berete, RC, Couitchere, L, Peric, S, Alemany-Rubio, E, Gonzalez-Rodriguez, L, Autrata, R, Kepak, T, Pochop, P, Svojgr, K, Gregersen, PA, Urbak, SF, Montero, MM, Budiongo, A, Yanga, JM, Amani, TBK, Lukamba, RM, Numbi, MN, Calle Jara, DA, Villacis Chafla, EG, Sanchez, GL, Abouelnaga, S, Afifi, MA, Elhaddad, AM, Ali, AM, Elzembely, M, Said, AMA, Ziko, OAO, Fuentes-Alabi, SL, Goenz, MA, Eerme, K, Klett, A, Hordofa, DF, Mengesha, AA, Sherief, ST, Kivela, TT, Nummi, K, Cassoux, N, Desjardins, L, Obono-Obiang, G, Kardava, T, Khotenashvili, Z, Bechrakis, NE, Biewald, EM, Schlueter, S, Ketteler, P, Amankwaa-Frempong, D, Essuman, VA, Paintsil, V, Renner, LA, Alejos, A, Giron, A, Carreras, YA, Fu, LD, Maldonado, C, Wong, ES, Yam, JC, Csoka, M, Maka, E, Aggarwal, P, Gupta, V, Bhaduri, A, Bhattacharyya, A, Das, A, Chawla, B, Das, P, Das, S, Gupta, H, Gupta, S, Verma, N, Kaliki, S, Khetan, V, Maitra, P, Mahajan, A, Menon, V, Mishra, DKC, Palanivelu, MS, Ramanjulu, R, Mudaliar, SS, Nair, AG, Natarajan, S, Seth, R, Singh, U, Bhat, S, Dudeja, G, Tripathy, D, Akib, IMNR, Pagarra, H, Amiruddin, PO, Kuntorini, MW, Armytasari, I, Supriyadi, E, Sutyawan, IWE, Yuliawati, P, Lutfi, D, Soebagjo, HD, Rahman, A, Sitorus, RS, Victor, AA, Tehuteru, ES, Widiarti, W, Nency, YM, Faranoush, M, Mehrvar, A, Tashvighi, M, Sedaghat, A, Ghassemi, F, Khodabande, A, Abdulqader, RA, Al-Shaheen, AASM, Al Ani, MH, Haydar, H, Al-Badri, SAF, Al-Jadiry, MF, Sabhan, AH, Al-Jumaily, U, Al-Mafrachi, AARM, Al-Shammary, EH, Al-Janabi, ANH, Qadir, AO, Capra, M, Blum, S, Gomel, N, Fabian, ID, Goldberg, H, Kapelushnik, N, Madgar, S, Vishnevskia-Dai, V, Frenkel, S, Pe'er, J, Gorfine, M, Refaeli, D, Steinberg, DM, Lavy, Y, Toledano, H, Caspi, S, De Francesco, S, Hadjistilianou, T, Ida, R, Valente, P, Midena, E, Parrozzani, R, Cowan-Lyn, KE, Vaughan, LO, Suzuki, S, Mohammad, MT, Yousef, YA, Manzhuova, L, Atsiaya, R, Matende, IO, Begimkulova, AS, Makimbetov, EK, Keomisy, J, Sayalith, P, Valeina, S, Viksnins, M, Al-Haddad, CE, Saab, RH, Alsawidi, KM, Elbahi, AM, Krivaitiene, D, Tateshi, B, Randrianarisoa, HL, Raobela, L, Msukwa, G, Nyirenda, C, Hamzah, N, Teh, KH, Sylla, F, Traore, F, Cheikh, SS, Zein, E, Perez, GG, Sanchez Orozco, AJ, Ortega-Hernandez, M, Ramirez-Ortiz, MA, Chuluunbat, T, Abdallah, E, Benmiloud, S, El Kettani, A, Hessissen, L, Almeida, AA, Limbu, B, Rajkarnikar, P, Saiju, R, Moll, AC, Wijsard, MVH, Cockcroft, RL, Ng, Y, Dodgshun, AJ, Calderon-Sotelo, P, Abdullahi, SU, Hassan, S, Umar, AB, Abdulrahaman, AA, Wali, AH, Ademola-Popoola, DS, Adio, A, Aghaji, AE, Ezegwui, IR, Akinsete, A, Musa, KO, Fasina, O, Ibanga, A, Nkanga, ED, Mustapha, T, Ribadu, D, Hummelen, M, Ahmad, A, Mushtaq, A, Qayyum, S, Chaudhry, S, Fadoo, Z, Jeeva, I, Masud, S, Hamid, SA, Zia, N, Siddiqui, SN, Janjua, T, Yaqub, MA, Khaqan, HA, Quintero D, K, Yee, R, Jairaj, V, Cano, MR, Fernandez, DDPG, Diaz Coronado, RY, Zapata Lopez, AM, Garcia, JL, Ponce, J, Garcia Pacheco, HN, Pascual Morales, CR, Vasquez Anchaya, JK, Tarrillo Leiva, FF, Alcasabas, APA, Mercado, GJ, Cieslik, K, Hautz, W, Rogowska, A, Castela, G, Silva, S, Jo, DH, Kim, JH, Comsa, C, Dragomir, MD, Neroev, V, Saakyan, S, Polyakov, V, Ushakova, TL, Yarovaya, VA, Yarovoy, AA, Theophile, T, Al Mesfer, S, Maktabi, A, Al-Dahmash, SA, Alkatan, HM, Moreira, C, Roth, PAN, Ilic, VR, Nikitovic, M, Latinovic, S, Quah, B, Tan, D, Hederova, S, Husakova, K, Groznik, AL, Pompe, MT, Davidson, A, Du Bruyn, M, Du Plessis, J, Stones, DK, Geel, JA, Myezo, KH, Kruger, M, Mayet, I, Naidu, G, Naidu, N, Mustak, H, Reynders, D, Wetter, J, Alarcon Portabella, S, Martin-Begue, N, Wolley Dod, C, Balaguer, J, Barranco, H, Catala-Mora, J, Correa Llano, MG, Fernandez-Teijeiro, A, Garcia Aldana, D, Peralta Calvo, J, San Roman Pacheco, S, Gunasekera, DS, Elhassan, MMA, Mohamedani, AA, All-Eriksson, C, Bartuma, K, Popovic, MB, Munier, FL, Liu, C-H, Chiwanga, FS, Kyara, A, Mndeme, FG, Msina, MS, Scanlan, TA, Atchaneeyasakul, L-O, Buaboonnam, J, Dangboon, W, Singha, P, Hongeng, S, Kulvichit, K, Rojanaporn, D, Surukrattanaskul, S, Wangtiraumnuay, N, Wiwatwongwana, A, Wiwatwongwana, D, Wongwai, P, Sharma, MK, Guedenon, KM, Bouguila, H, Atalay, HT, Hasanreisoglu, M, Ataseven, E, Kantar, M, Gunduz, AK, Kebudi, R, Kiratli, H, Koc, I, Tuncer, S, Unal, E, Kalinaki, A, Matua, M, Waddell, K, Musika, AA, Ssali, G, Al Harby, L, Reddy, MA, Astbury, NJ, Bascaran, C, Bowman, R, Burton, MJ, Foster, A, Zondervan, M, Sagoo, MS, Bobrova, N, Sorochynska, T, Lysytsia, L, Castillo, L, Afshar, AR, Berry, JL, Kim, JW, Randhawa, JK, Binkley, E, Boldt, HC, Larson, SA, Brennan, RC, Chandramohan, A, Stacey, AW, Corson, TW, Plager, DA, Davanzo, JM, Singh, AD, Demirci, H, Ericksen, C, Magrath, GN, Gold, AS, Murray, TG, Gonzalez, E, Shah, AS, Hansen, ED, Hartnett, ME, Harbour, JW, Hubbard, GB, Uner, OE, Laurenti, KD, Mets, MB, Leverant, AA, Ramasubramanian, A, Luna-Fineman, S, Miller, A, Skalet, AH, Mruthyunjaya, P, Hassan, M, Oliver, SC, Shields, CL, Yaghy, A, Stahl, ED, Wilson, MW, Villegas, VM, Islamov, Z, Usmanov, RH, Graells, J, Romero, L, Pham, CTM, Trang, DL, Al-Hussaini, HH, Thawaba, ADM, Muma, KIM, and Nyaywa, M

Abstract

BACKGROUND: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS: We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS: The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0-36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8-100·0) for children from high-income countries, 91·2% (89·5-93·0) for children from upper-middle-income countries, 80·3% (78·3-82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76-50·00), cT4 advanced tumour compared to

Published
2022

32. Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials

Author

Datamanagement 1, Research UMC Utrecht, CTM & Statistical consultation, MS Verloskunde, Child Health, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., Li, Wentao, Datamanagement 1, Research UMC Utrecht, CTM & Statistical consultation, MS Verloskunde, Child Health, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., and Li, Wentao

Published
2022

33. Alternative Randomized Trial Designs in Surgery: A Systematic Review

Author

Onderzoek Radiotherapie, Cancer, MS CGO, Trialbureau Beeld, MS HOD, CTM & Statistical consultation, Augustinus, Simone, van Goor, Iris W J M, Berkhof, Johannes, Daamen, Lois A, Groot Koerkamp, Bas, Mackay, Tara M, Molenaar, I Q, van Santvoort, Hjalmar C, Verkooijen, Helena M, van de Ven, Peter M, Besselink, Marc G, Onderzoek Radiotherapie, Cancer, MS CGO, Trialbureau Beeld, MS HOD, CTM & Statistical consultation, Augustinus, Simone, van Goor, Iris W J M, Berkhof, Johannes, Daamen, Lois A, Groot Koerkamp, Bas, Mackay, Tara M, Molenaar, I Q, van Santvoort, Hjalmar C, Verkooijen, Helena M, van de Ven, Peter M, and Besselink, Marc G

Published
2022

34. International changes in respiratory syncytial virus (RSV) epidemiology during the COVID-19 pandemic: Association with school closures

Author

CTM & Statistical consultation, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Billard, Marie Noëlle, van de Ven, Peter M., Baraldi, Bianca, Kragten-Tabatabaie, Leyla, Bont, Louis J., Wildenbeest, Joanne G., CTM & Statistical consultation, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Billard, Marie Noëlle, van de Ven, Peter M., Baraldi, Bianca, Kragten-Tabatabaie, Leyla, Bont, Louis J., and Wildenbeest, Joanne G.

Published
2022

35. Clinical outcomes of second relapsed and refractory first relapsed paediatric AML: A retrospective study within the NOPHO-DB SHIP consortium

Author

CTM & Statistical consultation, Biostatistiek Onderzoek, White, Tara, Kaspers, Gertjan, Abrahamsson, Jonas, Arad-Cohen, Nira, Cianci, Daniela, Fernandez, Jose, Ha, Shau Yin, Hasle, Henrik, De Moerloose, Barbara, Zwaan, C. Michel, Goemans, Bianca F., CTM & Statistical consultation, Biostatistiek Onderzoek, White, Tara, Kaspers, Gertjan, Abrahamsson, Jonas, Arad-Cohen, Nira, Cianci, Daniela, Fernandez, Jose, Ha, Shau Yin, Hasle, Henrik, De Moerloose, Barbara, Zwaan, C. Michel, and Goemans, Bianca F.

Published
2022

36. Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials

Author

Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, CTI Bont, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, RESCEU Investigators, Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, CTI Bont, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, and RESCEU Investigators

Published
2022

37. Analysing the protection from respiratory tract infections and allergic diseases early in life by human milk components: the PRIMA birth cohort

Author

CTI Leusen, Infection & Immunity, Datamanagement & Project Ondersteuning, CTM & Statistical consultation, Geboortecentrum voorzitterschap, Child Health, Longziekten patientenzorg, MS Dermatologie/Allergologie, CTI Van Wijk, Cancer, CTI Luminex, CTI Bont, Infectieziekten patientenzorg, DDOD, Brain, Infectieziekten onderzoek1 (Bont), PRIMA Initiative Group, CTI Leusen, Infection & Immunity, Datamanagement & Project Ondersteuning, CTM & Statistical consultation, Geboortecentrum voorzitterschap, Child Health, Longziekten patientenzorg, MS Dermatologie/Allergologie, CTI Van Wijk, Cancer, CTI Luminex, CTI Bont, Infectieziekten patientenzorg, DDOD, Brain, Infectieziekten onderzoek1 (Bont), and PRIMA Initiative Group

Published
2022

38. Clinical presentation, microbiological aetiology and disease course in patients with flu-like illness: a post hoc analysis of randomised controlled trial data

Author

HAG Infectieziekten, CTM & Statistical consultation, Biostatistiek Onderzoek, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Verheij, Theo, Cianci, Daniela, van der Velden, Alike, Butler, Christopher C, Bongard, Emily, Coenen, Samuel, Colliers, Annelies, Francis, Nick, Little, Paul, Godycki-Cwirko, Maciek, Llor, Carl, Chlabicz, Slawomir, Lionis, Christos, Sundvall, Pär-Daniel, Bjerrum, Lars, De Sutter, An, Aabenhus, Rune, Jonassen Harbin, Nicolay, Lindbaek, Morten, Glinz, Dominik, Bucher, Heiner, Kovacs, Bernadett, Seifert, Bohumil, Radzeviciene JUrgute, Ruta, Touboul Lundgren, Pia, de Paor, Muireann, Matheeussen, Veerle, Goossens, Herman, Ieven, Margareta, HAG Infectieziekten, CTM & Statistical consultation, Biostatistiek Onderzoek, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Verheij, Theo, Cianci, Daniela, van der Velden, Alike, Butler, Christopher C, Bongard, Emily, Coenen, Samuel, Colliers, Annelies, Francis, Nick, Little, Paul, Godycki-Cwirko, Maciek, Llor, Carl, Chlabicz, Slawomir, Lionis, Christos, Sundvall, Pär-Daniel, Bjerrum, Lars, De Sutter, An, Aabenhus, Rune, Jonassen Harbin, Nicolay, Lindbaek, Morten, Glinz, Dominik, Bucher, Heiner, Kovacs, Bernadett, Seifert, Bohumil, Radzeviciene JUrgute, Ruta, Touboul Lundgren, Pia, de Paor, Muireann, Matheeussen, Veerle, Goossens, Herman, and Ieven, Margareta

Published
2022

39. The GetReal Trial Tool: design, assess and discuss clinical drug trials in light of Real World Evidence generation

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Global Health team 1, Medical Humanities Onderzoek Team 1, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, CTM & Statistical consultation, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zuidgeest, Mira G.P., Goetz, Iris, Meinecke, Anna Katharina, Boateng, Daniel, Irving, Elaine A., van Thiel, Ghislaine J.M., Welsing, Paco M.J., Oude-Rengerink, Katrien, Grobbee, Diederick E., Global Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Global Health team 1, Medical Humanities Onderzoek Team 1, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, CTM & Statistical consultation, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zuidgeest, Mira G.P., Goetz, Iris, Meinecke, Anna Katharina, Boateng, Daniel, Irving, Elaine A., van Thiel, Ghislaine J.M., Welsing, Paco M.J., Oude-Rengerink, Katrien, and Grobbee, Diederick E.

Published
2022

40. The SNAP Trial: 2-Year Results of a Double-Blind Multicenter Randomized Controlled Trial of a Silicon Nitride Versus a PEEK Cage in Patients After Lumbar Fusion Surgery

Author

Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, CTM & Statistical consultation, Kersten, R F M R, Öner, F C, Arts, M P, Mitroiu, M, Roes, K C B, de Gast, A, van Gaalen, S M, Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, CTM & Statistical consultation, Kersten, R F M R, Öner, F C, Arts, M P, Mitroiu, M, Roes, K C B, de Gast, A, and van Gaalen, S M

Published
2022

41. Acute liver failure, multiorgan failure, cerebral oedema, and activation of proangiogenic and antiangiogenic factors in a case of Marburg haemorrhagic fever

Author

van Paassen, Judith, Bauer, Martijn P, Arbous, M Sesmu, Visser, Leo G, Schmidt-Chanasit, Jonas, Schilling, Stefan, Ölschläger, Stephan, Rieger, Toni, Emmerich, Petra, Schmetz, Christel, van de Berkmortel, Franchette, van Hoek, Bart, van Burgel, Nathalie D, Osterhaus, Albert D, Vossen, Ann CTM, Günther, Stephan, and van Dissel, Jaap T

Published
2012
Full Text
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42. Learning Center Guide.

Author

CTM, San Jose, CA., Cote, Bernard T., and Gurske, Barbara

Abstract

This guide assembles a helpful set of inexpensive ideas based on sound learning theory and successful classroom experience. Two major concepts are developed: (1) the learning center and (2) contract teaching. Learning centers are characterized by their flexibility and numerous opportunities for student involvement. They may be used for the development of one or more areas of the curriculum, or for extension, enrichment, improvement, independent activities, and special studies. Examples and sources of free or inexpensive materials that could be used in such centers are provided. The contract teaching method provides possibilities for student-teacher interaction and independent study. The method is described, types of contracts are explained, and sample contracts provided. Drawings and charts accompany the text. (Author/MLF)

Published
1972

45. Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

Author

Birkisdottir, MB, Jaarsma, Dick, Brandt, Renata, Barnhoorn, Sander, van Vliet, Nicole, Imholz, S, van Oostrom, CTM, Nagarajah, B, Portilla Fernández, Eliana, Roks, Anton, Elgersma, Ype, van Steeg, H, Ferreira, JA, Pennings, JLA, Hoeijmakers, Jan, Vermeij, WP, Dolle, MET, Birkisdottir, MB, Jaarsma, Dick, Brandt, Renata, Barnhoorn, Sander, van Vliet, Nicole, Imholz, S, van Oostrom, CTM, Nagarajah, B, Portilla Fernández, Eliana, Roks, Anton, Elgersma, Ype, van Steeg, H, Ferreira, JA, Pennings, JLA, Hoeijmakers, Jan, Vermeij, WP, and Dolle, MET

Abstract

Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve life span nor healthspan of DNA repair-deficient Ercc1∆/− mice, contrary to DR tested in parallel. Rapamycin interventions focusing on dosage, gender, and timing all were unable to alter life span. Even genetically modifying mTOR signaling failed to increase life span of DNA repair-deficient mice. The absence of effects by rapamycin on P53 in brain and transcription stress in liver is in sharp contrast with results obtained by DR, and appoints reducing DNA damage and transcription stress as an important mode of action of DR, lacking by rapamycin. Together, this indicates that mTOR inhibition does not mediate the beneficial effects of DR in progeroid mice, revealing that DR and rapamycin strongly differ in their modes of action.

Published
2021

46. Letter to the editor regarding 'Two-year results of a double-blind multicenter randomized controlled non-inferiority trial of polyetheretherketone (PEEK) versus silicon nitride spinal fusion cages in patients with symptomatic degenerative lumbar disc disorders'

Author

Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, CTM & Statistical consultation, Kersten, Roel F M R, Öner, F Cumhur, Arts, Mark P, Mitroiu, Marian, Roes, Kit C B, de Gast, Arthur, van Gaalen, Steven M, Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, CTM & Statistical consultation, Kersten, Roel F M R, Öner, F Cumhur, Arts, Mark P, Mitroiu, Marian, Roes, Kit C B, de Gast, Arthur, and van Gaalen, Steven M

Published
2021

47. Foley catheter vs oral misoprostol for induction of labor: individual participant data meta-analysis

Author

Geboortecentrum voorzitterschap, Child Health, CTM & Statistical consultation, Kemper, J. I., Li, W., Goni, S., Flanagan, M., Weeks, A., Alfirevic, Z., Bracken, H., Mundle, S., Goonewardene, M., ten Eikelder, M., Bloemenkamp, K., Rengerink, K. O., Kruit, H., Mol, B. W., Palmer, K. R., Geboortecentrum voorzitterschap, Child Health, CTM & Statistical consultation, Kemper, J. I., Li, W., Goni, S., Flanagan, M., Weeks, A., Alfirevic, Z., Bracken, H., Mundle, S., Goonewardene, M., ten Eikelder, M., Bloemenkamp, K., Rengerink, K. O., Kruit, H., Mol, B. W., and Palmer, K. R.

Published
2021

48. Burden of respiratory syncytial virus bronchiolitis on the Dutch pediatric intensive care units

Author

Infectieziekten onderzoek1 (Bont), Biostatistiek Onderzoek, CTM & Statistical consultation, Arts-assistenten Kinderen, CTI Bont, Child Health, Infection & Immunity, Infectiezieken, Intensive care patientenzorg, on behalf of the PICE Study Group, Infectieziekten onderzoek1 (Bont), Biostatistiek Onderzoek, CTM & Statistical consultation, Arts-assistenten Kinderen, CTI Bont, Child Health, Infection & Immunity, Infectiezieken, Intensive care patientenzorg, and on behalf of the PICE Study Group

Published
2021

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