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7. Corrigendum to “Effectiveness of L-serine supplementation in children with a GRIN2B loss-of-function mutation: Rationale and protocol for single patient (n-of-1) multiple cross-over trials” [Contemp. Clin. Trials Commun. 36 (2023)/ DOI: 10.1016/j.conctc.2023.101233] (Contemporary Clinical Trials Communications (2023) 36, (S2451865423001795), (10.1016/j.conctc.2023.101233))

Author

CTM & Statistical consultation, Cancer, Hollander, Bibiche den, Rothuizen-Lindenschot, Marieke, Geertjens, Lisa, Vaz, Frédéric M., Brands, Marion M., Le, Hoang Lan, van Eeghen, Agnies M., van de Ven, Peter M., Cornel, Martina C., Jacobs, Bart A.W., Bruining, Hilgo, van Karnebeek, Clara D., CTM & Statistical consultation, Cancer, Hollander, Bibiche den, Rothuizen-Lindenschot, Marieke, Geertjens, Lisa, Vaz, Frédéric M., Brands, Marion M., Le, Hoang Lan, van Eeghen, Agnies M., van de Ven, Peter M., Cornel, Martina C., Jacobs, Bart A.W., Bruining, Hilgo, and van Karnebeek, Clara D.

Published
2024

8. Patient preferences for disposable and reusable vaginal specula and their willingness to compromise in the era of climate change: A cross-sectional study

Author

CTM & Statistical consultation, Other research (not in main researchprogram), MS Verloskunde, Ten Buuren, Amber A.A., Poolman, Tessa B., Bongers, Marlies Y., Bullens, Lauren M., Van Hanegem, Nehalennia, Klerkx, Wenche M., Timmermans, Anne, Zuithoff, Nicolaas P.A., Kwee, Anneke, CTM & Statistical consultation, Other research (not in main researchprogram), MS Verloskunde, Ten Buuren, Amber A.A., Poolman, Tessa B., Bongers, Marlies Y., Bullens, Lauren M., Van Hanegem, Nehalennia, Klerkx, Wenche M., Timmermans, Anne, Zuithoff, Nicolaas P.A., and Kwee, Anneke

Published
2024

9. Did aetiology matter in illness duration and complications in patients presenting in primary care with acute respiratory tract infections early in the COVID-19 pandemic: An observational study in nine countries

Author

HAG Onderzoek, Infection & Immunity, Child Health, Biostatistiek Onderzoek, CTM & Statistical consultation, Other research (not in main researchprogram), HAG Infectieziekten, Ecraid, JC onderzoeksprogramma Infectieziekten, Venekamp, Roderick P, Eijkemans, Marinus J C, Zuithoff, Nicolaas P A, Böhmer, Femke, Chlabicz, Slawomir, Colliers, Annelies, García-Sangenís, Ana, Malania, Lile, Pauer, Jozsef, Tomacinschii, Angela, Verheij, Theo J, Goossens, Herman, Vellinga, Akke, Butler, Christopher C, van der Velden, Alike W, HAG Onderzoek, Infection & Immunity, Child Health, Biostatistiek Onderzoek, CTM & Statistical consultation, Other research (not in main researchprogram), HAG Infectieziekten, Ecraid, JC onderzoeksprogramma Infectieziekten, Venekamp, Roderick P, Eijkemans, Marinus J C, Zuithoff, Nicolaas P A, Böhmer, Femke, Chlabicz, Slawomir, Colliers, Annelies, García-Sangenís, Ana, Malania, Lile, Pauer, Jozsef, Tomacinschii, Angela, Verheij, Theo J, Goossens, Herman, Vellinga, Akke, Butler, Christopher C, and van der Velden, Alike W

Published
2024

10. Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials

Author

CTM & Statistical consultation, Cancer, Neurologen, Brain, TN groep Pasterkamp, Müller, A. R., den Hollander, B., van de Ven, P. M., Roes, K. C.B., Geertjens, L., Bruining, H., van Karnebeek, C. D.M., Jansen, F. E., de Wit, M. C.Y., ten Hoopen, L. W., Rietman, A. B., Dierckx, B., Wijburg, F. A., Boot, E., Brands, M. M.G., van Eeghen, A. M., CTM & Statistical consultation, Cancer, Neurologen, Brain, TN groep Pasterkamp, Müller, A. R., den Hollander, B., van de Ven, P. M., Roes, K. C.B., Geertjens, L., Bruining, H., van Karnebeek, C. D.M., Jansen, F. E., de Wit, M. C.Y., ten Hoopen, L. W., Rietman, A. B., Dierckx, B., Wijburg, F. A., Boot, E., Brands, M. M.G., and van Eeghen, A. M.

Published
2024

11. Effect of dupilumab on asthma and aeroallergen sensitization in pediatric atopic dermatitis patients: Results of the BioDay registry

Author

Infection & Immunity, MS Dermatologie/Allergologie, CTM & Statistical consultation, Other research (not in main researchprogram), Rijst, Lisa P van der, Groot, Karin M de Winter-de, Zuithoff, Nicolaas P A, de Bruin-Weller, Marjolein S, de Graaf, Marlies, Infection & Immunity, MS Dermatologie/Allergologie, CTM & Statistical consultation, Other research (not in main researchprogram), Rijst, Lisa P van der, Groot, Karin M de Winter-de, Zuithoff, Nicolaas P A, de Bruin-Weller, Marjolein S, and de Graaf, Marlies

Published
2024

12. Natural variability of TRAIL, IP-10, and CRP in healthy adults - The 'HERACLES' study

Author

Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, MMB, CTI Bont, Zorg en O&O, Child Health, Langedijk, Annefleur C, Rengerink, Katrien Oude, Harding, Eline, Wensing, Annemarie, van Slooten, Rianne, Israeli, Yael, Rosenberg, Michal, Gottlieb, Tanya, Eden, Eran, Bont, Louis J, Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, MMB, CTI Bont, Zorg en O&O, Child Health, Langedijk, Annefleur C, Rengerink, Katrien Oude, Harding, Eline, Wensing, Annemarie, van Slooten, Rianne, Israeli, Yael, Rosenberg, Michal, Gottlieb, Tanya, Eden, Eran, and Bont, Louis J

Published
2024

13. Rationale and design for the randomized placebo-controlled double-blind trial studying the effect of single antiplatelet therapy (clopidogrel) versus dual antiplatelet therapy (clopidogrel/acetylsalicylic acid) on the occurrence of atherothrombotic events following lower extremity peripheral transluminal angioplasty (CLEAR-PATH)

Author

Zorgeenheid Vaatchirurgie Medisch, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Cancer, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Regenerative Medicine and Stem Cells, Wegerif, Emilien C.J., Ünlü, Çağdaş, Generaal, Manon I., van den Bor, Rutger M., van de Ven, Peter M., Bots, Michiel L., de Borst, Gert J., Zorgeenheid Vaatchirurgie Medisch, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Cancer, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Regenerative Medicine and Stem Cells, Wegerif, Emilien C.J., Ünlü, Çağdaş, Generaal, Manon I., van den Bor, Rutger M., van de Ven, Peter M., Bots, Michiel L., and de Borst, Gert J.

Published
2024

14. Do efficacy results obtained from randomized controlled trials translate to effectiveness data from observational studies for relapsing–remitting multiple sclerosis?

Author

CTM & Statistical consultation, JC onderzoeksprogramma Methodologie, Verweij, Stefan, Ahmed, Wouter, Zhou, Guiling, Mavridis, Dimitris, Nikolakopoulos, Stavros, Elferink, Andre J., Rengerink, Katrien Oude, Bijlsma, Maarten J., Mol, Peter G.M., Hak, Eelko, CTM & Statistical consultation, JC onderzoeksprogramma Methodologie, Verweij, Stefan, Ahmed, Wouter, Zhou, Guiling, Mavridis, Dimitris, Nikolakopoulos, Stavros, Elferink, Andre J., Rengerink, Katrien Oude, Bijlsma, Maarten J., Mol, Peter G.M., and Hak, Eelko

Published
2024

15. Dupilumab induces a significant decrease of food specific immunoglobulin E levels in pediatric atopic dermatitis patients

Author

MS Dermatologie/Allergologie, Infection & Immunity, Other research (not in main researchprogram), CTM & Statistical consultation, van der Rijst, Lisa, Hilbrands, Michelle, Zuithoff, Peter, de Bruin-Weller, Marjolein, Knulst, André C., Le, Thuy-My, de Graaf, Marlies, MS Dermatologie/Allergologie, Infection & Immunity, Other research (not in main researchprogram), CTM & Statistical consultation, van der Rijst, Lisa, Hilbrands, Michelle, Zuithoff, Peter, de Bruin-Weller, Marjolein, Knulst, André C., Le, Thuy-My, and de Graaf, Marlies

Published
2024

16. The reliability and validity of the juvenile idiopathic arthritis magnetic resonance scoring system for temporomandibular joints

Author

MS Mondziekten/Kaakchirurgie, MS Hoofd-Hals Chirurgische Oncologie, MKA/BT Onderzoek, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiologie, Immuno/reuma ERN, Regenerative Medicine and Stem Cells, Zorgeenheid MKA/BT Medisch, de Sonnaville, Willemijn, Speksnijder, Caroline, Zuithoff, Peter, ter Horst, Simone, Nap, Frank, Wulffraat, Nico, Steenks, MH, Rosenberg, Antoine Jwp, MS Mondziekten/Kaakchirurgie, MS Hoofd-Hals Chirurgische Oncologie, MKA/BT Onderzoek, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiologie, Immuno/reuma ERN, Regenerative Medicine and Stem Cells, Zorgeenheid MKA/BT Medisch, de Sonnaville, Willemijn, Speksnijder, Caroline, Zuithoff, Peter, ter Horst, Simone, Nap, Frank, Wulffraat, Nico, Steenks, MH, and Rosenberg, Antoine Jwp

Published
2024

17. Breaking the chains of lipoprotein lipase deficiency: A pediatric perspective on the efficacy and safety of Volanesorsen

Author

CTM & Statistical consultation, Cancer, den Hollander, Bibiche, Brands, Marion M., Nijhuis, Ilse J.M., Doude van Troostwijk, Lous J.A.E., van Essen, Peter, Hofsteenge, Ageeth H., Koot, Bart G., Müller, Annelieke R., Tseng, Laura A., Stroes, Erik S.G., van de Ven, Peter M., Wiegman, Albert, van Karnebeek, Clara D.M., CTM & Statistical consultation, Cancer, den Hollander, Bibiche, Brands, Marion M., Nijhuis, Ilse J.M., Doude van Troostwijk, Lous J.A.E., van Essen, Peter, Hofsteenge, Ageeth H., Koot, Bart G., Müller, Annelieke R., Tseng, Laura A., Stroes, Erik S.G., van de Ven, Peter M., Wiegman, Albert, and van Karnebeek, Clara D.M.

Published
2024

18. Energy and nutrient intake in the Netherlands. Results of the Dutch National Food Consumption Survey 2019-2021

Author

Sanderman-Nawijn, EL, Brants, HAM, Dinnissen, CS, Ocké, MC, van Rossum, CTM, Sanderman-Nawijn, EL, Brants, HAM, Dinnissen, CS, Ocké, MC, and van Rossum, CTM

Abstract

RIVM rapport:De Nationale Voedselconsumptiepeiling 2019-2021 (VCP) geeft inzicht in wat, waar en wanneer Nederlanders eten en drinken. Dit rapport gaat in op de hoeveelheid energie en voedingsstoffen die mensen binnenkrijgen. De resultaten van ruim 3500 kinderen en volwassenen zijn vergeleken met de eerdere peilingen in 2007-2010 en 2012-2016. Hierbij is onderscheid gemaakt naar verschillende leeftijdsgroepen en geslacht. Het blijkt dat inwoners van Nederland de laatste jaren gemiddeld minder suiker en zout en meer vezels binnenkrijgen dan bij de vorige peiling in 2012-2016. Wel krijgen mensen nog te veel zout en te weinig vezel binnen. Ook drinken mensen, vooral mannen, minder alcohol. De gevonden ontwikkelingen zijn gunstig voor de gezondheid. Aangezien minder suiker en meer vezel in eten en drinken kan helpen om overgewicht en chronische ziekten te voorkomen. Minder zout is belangrijk voor een goede bloeddruk. Daarnaast krijgen alle leeftijdsgroepen meer vitamine D binnen. Ouderen in de leeftijd van 70-79 jaar krijgen nog steeds vaak te weinig van deze vitamine binnen. Voor hen is het belangrijk om het advies om vitamine D-supplementen te slikken, beter op te volgen. Genoeg vitamine D in combinatie met voldoende calcium maakt de kans op botbreuken kleiner. Er zijn nog andere voedingsstoffen die mensen nog veel of weinig binnenkrijgen in vergelijking met de voedingsnormen. Zo krijgen sommige bevolkingsgroepen weinig vitamines A, B2, B6, B11, C, calcium en ijzer binnen. Dit verschilt per leeftijdsgroep en geslacht. Als mensen weinig van zo'n voedingstof binnenkrijgen, hoeft dat niet meteen zorgelijk te zijn. Verder onderzoek, bijvoorbeeld naar hoeveel voedingsstoffen in het lichaam zitten en gezondheidsklachten, is wenselijk om hier meer inzicht in te krijgen en zo nodig maatregelen te kunnen nemen. Dit geldt ook voor vitamines en mineralen waar mensen veel van binnenkrijgen, zoals magnesium. Met gegevens van de VCP kunnen beleidsmakers en professionals werken aan een gezond en, The Dutch National Food Consumption Survey (DNFCS) 2019-2021 sheds light on what Dutch people eat and drink, where and how much. This report delves into the intake of energy and nutrients. Comparing data from over 3500 children and adults, with previous surveys conducted in 2007-2010 and 2012-2016, we examine trends across different age-gender groups. Recent years have shown a positive shift in Dutch diets: on average, there's been a reduction in sugar and salt intake and an increase in fibre consumption compared to the 2012-2016 survey. However, salt intake remains high and fibre intake is still insufficient. Notably, alcohol consumption, particularly among men, has decreased. These trends bode well for health, as less sugar and more fibre intake can aid in preventing overweight and chronic diseases, while low salt intake is important for a healthy blood pressure. Moreover, there's been an overall increase in vitamin D intake across all age groups. Nevertheless, older adults aged 70-79 often fall short on vitamin D intake. For this age group, it is important to take better note of the recommendation to take vitamin D supplements. Sufficient intake of vitamin D in combination with sufficient calcium reduces the risk of bone fractures. There are still other nutrients that people consume either too much or too little compared to dietary reference values. Some population groups have low intake of vitamins A, B2, B6, B11, C, calcium and iron. This varies by age group and gender. However, a deficiency in a nutrient may not immediately warrant concern. Further investigation, including assessing nutrient levels in the body and prevalence of clinical signs, is necessary to understand these patterns better and take measures if needed. This also applies to vitamins and minerals like magnesium, of which some individuals have high intakes. The DNFCS data makes it possible for policymakers and professionals to continue their work on healthy and sustainable diets, product innovat

Published
2024

19. Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer: the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group

Author

Medisch Oncologische Disciplines, MS Medische Oncologie, Hart- en Vaatziekten Team A, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, CTM & Statistical consultation, Epi Kanker Team B, Researchgr. Nucleaire Geneeskunde, Zorgeenheid Kinderchirurgie Medisch, MS CGO, van der Kruijssen, D. E.W., Elias, S. G., van de Ven, P. M., van Rooijen, K. L., Lam-Boer, J. ’t, Mol, L., Punt, C. J.A., Sommeijer, D. W., Tanis, P. J., Nielsen, J. D., Yilmaz, M. K., van Riel, J. M.G.H., Wasowiz-Kemps, D. K., Loosveld, O. J.L., van der Schelling, G. P., de Groot, J. W.B., van Westreenen, H. L., Jakobsen, H. L., Fromm, A. L., Hamberg, P., Verseveld, M., Jaensch, C., Liposits, G. I., van Duijvendijk, P., Oulad Hadj, J., van der Hoeven, J. A.B., Trajkovic, M., de Wilt, J. H.W., Koopman, M., van Grevenstein, W. M.U.Helma, CAIRO4 Working Group, Medisch Oncologische Disciplines, MS Medische Oncologie, Hart- en Vaatziekten Team A, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, CTM & Statistical consultation, Epi Kanker Team B, Researchgr. Nucleaire Geneeskunde, Zorgeenheid Kinderchirurgie Medisch, MS CGO, van der Kruijssen, D. E.W., Elias, S. G., van de Ven, P. M., van Rooijen, K. L., Lam-Boer, J. ’t, Mol, L., Punt, C. J.A., Sommeijer, D. W., Tanis, P. J., Nielsen, J. D., Yilmaz, M. K., van Riel, J. M.G.H., Wasowiz-Kemps, D. K., Loosveld, O. J.L., van der Schelling, G. P., de Groot, J. W.B., van Westreenen, H. L., Jakobsen, H. L., Fromm, A. L., Hamberg, P., Verseveld, M., Jaensch, C., Liposits, G. I., van Duijvendijk, P., Oulad Hadj, J., van der Hoeven, J. A.B., Trajkovic, M., de Wilt, J. H.W., Koopman, M., van Grevenstein, W. M.U.Helma, and CAIRO4 Working Group

Published
2024

20. The multiple mediating effects of vision-specific factors and depression on the association between visual impairment severity and fatigue: a path analysis study

Author

CTM & Statistical consultation, Cancer, Schakel, Wouter, Bode, Christina, van de Ven, Peter M., van der Aa, Hilde P.A., Hulshof, Carel T.J., van Rens, Gerardus H.M.B., van Nispen, Ruth M.A., CTM & Statistical consultation, Cancer, Schakel, Wouter, Bode, Christina, van de Ven, Peter M., van der Aa, Hilde P.A., Hulshof, Carel T.J., van Rens, Gerardus H.M.B., and van Nispen, Ruth M.A.

Published
2024

21. Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis

Author

Longziekten onderzoek 1, Regenerative Medicine and Stem Cells, Beleid & Communicatie, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Arts Assistenten Longziekten, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Longziekten onderzoek 2, Onderzoek, Bierlaagh, Marlou C., Ramalho, Anabela S., Silva, Iris A.L., Vonk, Annelotte M., van den Bor, Rutger M., van Mourik, Peter, Pott, Johanna, Suen, Sylvia W.F., Boj, Sylvia F., Vries, Robert G.J., Lammertyn, Elise, Vermeulen, François, Amaral, Margarida D., de Boeck, Kris, van der Ent, Cornelis K., Beekman, Jeffrey M., Longziekten onderzoek 1, Regenerative Medicine and Stem Cells, Beleid & Communicatie, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Arts Assistenten Longziekten, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Longziekten onderzoek 2, Onderzoek, Bierlaagh, Marlou C., Ramalho, Anabela S., Silva, Iris A.L., Vonk, Annelotte M., van den Bor, Rutger M., van Mourik, Peter, Pott, Johanna, Suen, Sylvia W.F., Boj, Sylvia F., Vries, Robert G.J., Lammertyn, Elise, Vermeulen, François, Amaral, Margarida D., de Boeck, Kris, van der Ent, Cornelis K., and Beekman, Jeffrey M.

Published
2024

22. Key lifestyles and health outcomes across 16 prevalent chronic diseases: A network analysis of an international observational study.

Author

Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Man Ho, M, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, Youssef, N, Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Man Ho, M, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, and Youssef, N

Abstract

BACKGROUND: Central and bridge nodes can drive significant overall improvements within their respective networks. We aimed to identify them in 16 prevalent chronic diseases during the coronavirus disease 2019 (COVID-19) pandemic to guide effective intervention strategies and appropriate resource allocation for most significant holistic lifestyle and health improvements. METHODS: We surveyed 16 512 adults from July 2020 to August 2021 in 30 territories. Participants self-reported their medical histories and the perceived impact of COVID-19 on 18 lifestyle factors and 13 health outcomes. For each disease subgroup, we generated lifestyle, health outcome, and bridge networks. Variables with the highest centrality indices in each were identified central or bridge. We validated these networks using nonparametric and case-dropping subset bootstrapping and confirmed central and bridge variables' significantly higher indices through a centrality difference test. FINDINGS: Among the 48 networks, 44 were validated (all correlation-stability coefficients >0.25). Six central lifestyle factors were identified: less consumption of snacks (for the chronic disease: anxiety), less sugary drinks (cancer, gastric ulcer, hypertension, insomnia, and pre-diabetes), less smoking tobacco (chronic obstructive pulmonary disease), frequency of exercise (depression and fatty liver disease), duration of exercise (irritable bowel syndrome), and overall amount of exercise (autoimmune disease, diabetes, eczema, heart attack, and high cholesterol). Two central health outcomes emerged: less emotional distress (chronic obstructive pulmonary disease, eczema, fatty liver disease, gastric ulcer, heart attack, high cholesterol, hypertension, insomnia, and pre-diabetes) and quality of life (anxiety, autoimmune disease, cancer, depression, diabetes, and irritable bowel syndrome). Four bridge lifestyles were identified: consumption of fruits and vegetables (diabetes, high cholesterol, hypertension, and insom

Published
2024

23. Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial

Author

HAG Trombose, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTM & Statistical consultation, Cancer, MS Geriatrie, Circulatory Health, Directie Raad van Bestuur, HAG Hart- Vaatziekten, Joosten, Linda P T, van Doorn, Sander, van de Ven, Peter M, Köhlen, Bart T G, Nierman, Melchior C, Koek, Huiberdina L, Hemels, Martin E W, Huisman, Menno V, Kruip, Marieke, Faber, Laura M, Wiersma, Nynke M, Buding, Wim F, Fijnheer, Rob, Adriaansen, Henk J, Roes, Kit C, Hoes, Arno W, Rutten, Frans H, Geersing, Geert-Jan, HAG Trombose, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTM & Statistical consultation, Cancer, MS Geriatrie, Circulatory Health, Directie Raad van Bestuur, HAG Hart- Vaatziekten, Joosten, Linda P T, van Doorn, Sander, van de Ven, Peter M, Köhlen, Bart T G, Nierman, Melchior C, Koek, Huiberdina L, Hemels, Martin E W, Huisman, Menno V, Kruip, Marieke, Faber, Laura M, Wiersma, Nynke M, Buding, Wim F, Fijnheer, Rob, Adriaansen, Henk J, Roes, Kit C, Hoes, Arno W, Rutten, Frans H, and Geersing, Geert-Jan

Published
2024

24. Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer: A Randomized Clinical Trial

Author

Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiotherapie, Mink van der Molen, Dieuwke R, Batenburg, Marilot C T, Maarse, Wiesje, van den Bongard, Desiree H J G, Doeksen, Annemiek, de Lange, Marjoleine Y, van der Pol, Carmen C, Evers, Daniel J, Lansdorp, Corine A, van der Laan, Jacco, van de Ven, Peter M, van der Leij, Femke, Verkooijen, Helena M, Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiotherapie, Mink van der Molen, Dieuwke R, Batenburg, Marilot C T, Maarse, Wiesje, van den Bongard, Desiree H J G, Doeksen, Annemiek, de Lange, Marjoleine Y, van der Pol, Carmen C, Evers, Daniel J, Lansdorp, Corine A, van der Laan, Jacco, van de Ven, Peter M, van der Leij, Femke, and Verkooijen, Helena M

Published
2024

25. Anatomical Markers Associated With the Presence of Intracranial Aneurysms in Individuals Screened for Aneurysms

Author

Cancer, Beeldverwerking ISI, Highfield Research Group, Brain, Opleiding Neurologie, Other research (not in main researchprogram), CTM & Statistical consultation, Neurologen, Circulatory Health, Structure and Connections, Regenerative Medicine and Stem Cells, MS Radiologie, Researchgr. Hart-brein as., Vos, Iris, van Tuijl, Rick, Mensing, Liselore, Ophelders, Maud, Velthuis, Mireille, Zuithoff, Peter, Rinkel, GJE, Kuijf, Hugo, Zwanenburg, JJM, van der Schaaf, Irene, Velthuis, Birgitta, Ruigrok, YM, Cancer, Beeldverwerking ISI, Highfield Research Group, Brain, Opleiding Neurologie, Other research (not in main researchprogram), CTM & Statistical consultation, Neurologen, Circulatory Health, Structure and Connections, Regenerative Medicine and Stem Cells, MS Radiologie, Researchgr. Hart-brein as., Vos, Iris, van Tuijl, Rick, Mensing, Liselore, Ophelders, Maud, Velthuis, Mireille, Zuithoff, Peter, Rinkel, GJE, Kuijf, Hugo, Zwanenburg, JJM, van der Schaaf, Irene, Velthuis, Birgitta, and Ruigrok, YM

Published
2024

26. A compact single radiator CRLH-inspired circularly polarized leaky-wave antenna based on substrate-integrated waveguide

Author

Lee, H, Choi, JH, Wu, CTM, and Itoh, T

Subjects
Circular polarization, composite right/left handed, leaky-wave antenna, substrate-integrated waveguide, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies
Abstract

A circularly polarized (CP) CRLH-inspired leaky-wave antenna (LWA) based on substrate-integrated waveguide (SIW) and microstrip delay line is presented. The unit-cell of the proposed periodic antenna consists of two conventional CRLH SIW cells and two quarter-wavelength microstrip lines. The interdigital slots on the CRLH SIW are rotated at +45° and -45° with respect to the wave propagation direction and separated by 90° to create circular polarization. Utilizing the microstrip line instead of the SIW delay section, the total size of the five unit-cell antenna is reduced by 24.4% in comparison to the previous single radiator CP LWA. Furthermore, microstrip lines provide improved matching for broadside radiation as well as better CP purity. The unitcell characteristics are investigated in detail through dispersion and Bloch impedance analysis. In addition, space harmonic analysis is carried out to explain the radiation mechanism of the proposed antenna. The proposed CRLH-inspired SIW CP antenna operates from 4.2 to 4.85 GHz and frequency scans from -25° to 26° along the elevation angle. Axial ratio is maintained below 3 dB throughout the operating frequency. The measured results show good agreement with the simulated results.

Published
2015

27. Magnetic-current-loop-induced electric dipole antenna based on substrate integrated waveguide cavity

Author

Wu, CTM, Choi, JH, Lee, H, and Itoh, T

Subjects
Annular ring, antenna array, dipole antenna, magnetic current, substrate integrated waveguide, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies
Abstract

In this letter, a novel dipole antenna based on substrate integrated waveguides (SIWs) is presented. The dipole antenna radiates through the equivalent magnetic current loops on the top and bottom annular ring slot that is excited by the fundamental mode of the SIW cavity. Therefore, the proposed dipole possesses a vertical polarization perpendicular to the metallic plane. Moreover, thanks to normal electric field, the proposed dipole is less affected by the ground plane size and surrounding metal. The proposed antenna topology provides a very easy way to realize vertical dipole antenna by just using planar circuits and is promising to be used as a fundamental element to realize antenna arrays. © 2002-2011 IEEE.

Published
2014

28. Maximally flat negative group-delay circuit: A microwave transversal filter approach

Author

Wu, CTM and Itoh, T

Subjects
Anomalous dispersion, directional couplers, dispersion engineering, distributed amplifiers, negative group delay, transversal filters, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies
Abstract

A comprehensive method to synthesize negative group delay (NGD) in the microwave regime with a maximally flat response is proposed in this paper. This method is based on transversal-filter topologies; it will be shown that by choosing proper coupling coefficients of each tap of a transversal filter, we can realize NGDs with maximally flat characteristics at the output of the transversal filter. The desired coefficients to realize maximally flat NGDs with various amount of group delay are analytically derived and tabulated in this paper. Furthermore, the results are verified experimentally through microwave transversal-filter approaches in both passive and active ways using multi-section asymmetric directional couplers and distributed amplifiers. © 1963-2012 IEEE.

Published
2014

29. Study and analysis of contiguous channel triplexer based on combining method of two filtering circuits using CRLH and RH isolation circuits

Author

Lee, H, Wu, CTM, and Itoh, T

Subjects
Passive Components and Circuits, Meta-materials and Photonic Bandgap Structures
Abstract

Several types of multiplexers based on isolation circuits have been introduced and investigated. Combining method of two filtering circuits (CMTC) is one way to make multiplexers based on isolation circuits. This method fits well for designing contiguous channel triplexers. A triplexer based on CMTC consists of a conventional transmission line (TL) connected to a diplexer and a composite right/left-handed (CRLH) TL connected to a filter. The triplexer based on CMTC has two significant advantages. One is that it is not necessary to modify the design of a stand-alone filter and diplexer and there is freedom in the choice of filtering circuits. In addition, a designer does not need to perform three-dimensional full-wave optimization, because of a simple and straightforward design concept. In this paper, a triplexer prototype having 1, 1.125, and 1.25 GHz center frequencies, is designed and fabricated. The measured results show good agreement with the simulation results. © Cambridge University Press and the European Microwave Association 2014.

Published
2014

30. A dual-purpose reconfigurable negative group delay circuit based on distributed amplifiers

Author

Wu, CTM, Gharavi, S, Daneshrad, B, and Itoh, T

Subjects
Dispersion engineering, distributed amplifier, dynamic power supply, negative group delay, superluminal group velocity, transversal filter, Networking & Telecommunications, Electrical and Electronic Engineering, Communications Technologies, Optical Physics
Abstract

In this letter, a novel reconfigurable negative group delay distributed amplifier (NGD-DA) circuit is proposed. This NGD-DA offers a new method to realize negative group delay. By properly choosing the gain coefficient of each tap for the DA, we can synthesize the negative group delay at the reverse port of the DA in the frequency band of interest, while maintaining a flat gain at the forward port; this results in a dual-purpose DA. Moreover, the proposed NGD-DA is reconfigurable; the phase response at the reverse port can be simply controlled by adjusting the tap gain coefficients, and therefore the bandwidth as well as the amount of negative group delay can be manipulated. The proposed active NGD circuit is validated through theoretical explanation and experimental results. © 2013 IEEE.

Published
2013

31. Voedselverkooppunten in beeld. Een inventarisatie van mogelijke indicatoren en databronnen

Author

RE Vellinga, EAP Martens, and CTM van Rossum

Subjects
RIVM rapport 2023-0244
Abstract

De voedselomgeving bepaalt voor een groot deel wat mensen kopen, en dus of mensen gezond of ongezond eten. De voedselomgeving is alles wat kan bepalen wat we eten: van aanbod, prijzen, aanbiedingen, informatie en verkooppunten, tot sociale normen, culturele eetgewoonten en wettelijke afspraken. Ongezonde voeding vergroot de kans op overgewicht en chronische ziekten als hart- en vaatziekten en diabetes type 2. De Nederlandse overheid werkt daarom aan een voedselomgeving die mensen helpt om gezondere keuzes te maken. Om beleid te kunnen maken, is inzicht nodig in de verschillende onderdelen van de voedselomgeving. Het ministerie van VWS(Ministerie van Volksgezondheid, Welzijn en Sport ) wil daarom onder andere inventariseren hoe de verkooppunten van voedsel in kaart kunnen worden gebracht. Hieronder vallen alle verkooppunten van alle soorten voedsel, dus van groenteboer en supermarkt tot restaurant en snackbar. Het RIVM geeft voorbeelden hoe de verkooppunten in kaart kunnen worden gebracht (indicatoren) en welke informatie (databronnen) hierover in Nederland beschikbaar is. De twee belangrijkste indicatoren zijn: de ‘dichtheid’ en ‘nabijheid’ van verkooppunten. Met dichtheid bedoelen we hoeveel verkooppunten er in een bepaald gebied zijn, bijvoorbeeld hoeveel verkooppunten in een wijk. Bij nabijheid gaat het erom hoe ver een verkooppunt ligt van bijvoorbeeld een school of woonwijk. Om te kunnen bepalen welke indicatoren en databronnen te gebruiken zijn, moet eerst het doel van de monitor van de hele voedselomgeving duidelijk worden. Zo moet worden bepaald of de monitor nodig is om beleid over de voedselomgeving op landelijk niveau te ontwikkelen. Of juist om beleid over specifieke vraagstukken voor een gemeente te evalueren. Ook kan de mate waarin het voedselaanbod gezond en duurzaam is onderdeel van de monitor zijn. Het monitoren van de verkooppunten kan onderdeel zijn van een brede monitor van de voedselomgeving.

Published
2023

32. Effectiveness of L-serine supplementation in children with a GRIN2B loss-of-function mutation: Rationale and protocol for single patient (n-of-1) multiple cross-over trials

Author

CTM & Statistical consultation, Cancer, Onderzoek, den Hollander, Bibiche, Rothuizen-Lindenschot, Marieke, Geertjens, Lisa, Vaz, Frédéric M., Brands, Marion M., Le, Hoang Lan, van Eeghen, Agnies M., van de Ven, Peter M., Cornel, Martina C., Jacobs, Bart A.W., Bruining, Hilgo, van Karnebeek, Clara D., CTM & Statistical consultation, Cancer, Onderzoek, den Hollander, Bibiche, Rothuizen-Lindenschot, Marieke, Geertjens, Lisa, Vaz, Frédéric M., Brands, Marion M., Le, Hoang Lan, van Eeghen, Agnies M., van de Ven, Peter M., Cornel, Martina C., Jacobs, Bart A.W., Bruining, Hilgo, and van Karnebeek, Clara D.

Published
2023

33. Graphical tools for visualizing the results of network meta-analysis of multicomponent interventions

Author

CTM & Statistical consultation, JC onderzoeksprogramma Methodologie, Biostatistiek Onderzoek, Seitidis, Georgios, Tsokani, Sofia, Christogiannis, Christos, Kontouli, Katerina Maria, Fyraridis, Alexandros, Nikolakopoulos, Stavros, Veroniki, Areti Angeliki, Mavridis, Dimitris, CTM & Statistical consultation, JC onderzoeksprogramma Methodologie, Biostatistiek Onderzoek, Seitidis, Georgios, Tsokani, Sofia, Christogiannis, Christos, Kontouli, Katerina Maria, Fyraridis, Alexandros, Nikolakopoulos, Stavros, Veroniki, Areti Angeliki, and Mavridis, Dimitris

Published
2023

34. Disparities in access to ear and hearing care in Cambodia: a mixed methods study on patient experiences

Author

Waterworth, CJ, Watters, CTM, Sokdavy, T, Annear, PL, Dowell, R, Grimes, CE, Bhutta, MF, Waterworth, CJ, Watters, CTM, Sokdavy, T, Annear, PL, Dowell, R, Grimes, CE, and Bhutta, MF

Abstract

OBJECTIVE: Chronic suppurative otitis media is a major global disease disproportionately affecting low- and middle-income countries, but few studies have explored access to care for those with ear and hearing disorders. METHOD: In a tertiary hospital in Cambodia providing specialist ear services, a mixed method study was undertaken. This study had three arms: (1) quantitative analysis of patients undergoing ear surgery, (2) a questionnaire survey and (3) semi-structured in-depth interviews. RESULTS: Patients presented with advanced middle-ear disease and associated hearing loss at rates that are amongst the highest per capita levels globally. Patients reported several structural, financial and socio-cultural barriers to treatment. This study showed a significant burden of ear disease in Cambodia, which reflects a delay in receiving timely and effective treatment. CONCLUSION: This study highlights the opportunity to integrate effective ear and hearing care into primary care service provision, strengthening the package of activities delivered at government facilities.

Published
2023

35. The diet of the Dutch. Results of the Dutch National Food Consumption Survey 2019- 2021 on food consumption and evaluation with dietary guidelines

Author

van Rossum, CTM, Sanderman-Nawijn, EL, Brants, HAM, Dinnissen, CS, Jansen-van der Vliet, M, Beukers, MH, Ockë, MC, van Rossum, CTM, Sanderman-Nawijn, EL, Brants, HAM, Dinnissen, CS, Jansen-van der Vliet, M, Beukers, MH, and Ockë, MC

Abstract

RIVM rapport:The Dutch National Food Consumption Survey (DNFCS) 2019-2021 shows what Dutch people eat and drink, and how much. The DNFCS also shows the level of adherence to the Dutch dietary guidelines and changes to this level since the previous surveys in 2012-2016 and 2007- 2010. In recent years, the Dutch have been eating more healthily. One of the reasons for this is that they have been eating more vegetable products, such as vegetables, fruit, unsalted nuts and legumes. At the same time, they have been consuming less red and/or processed meat and sugarcontaining beverages. Most improvements are apparent in both adults and children. People have also been using more dietary supplements, including supplements with vitamin D. In spite of this, the diets of most Dutch people do not comply with the Dutch dietary guidelines. Generally speaking, the diets of women, those aged over 65 and those educated to a higher level follow the Dutch dietary guidelines more closely than the diets of men, young adults and those with a lower level of education. These guidelines form the basis for the Netherlands Nutrition Centre’s Wheel of Five. A healthier diet can help prevent overweight and chronic diseases, such as cardiovascular disease. For this edition of the survey, RIVM researched the diets of over 3,500 children and adults. The data make it possible for policymakers and professionals to continue their work on the development of healthy and sustainable diets, product innovation, education and research. This report describes and discusses the survey method and results in detail. It is intended for a target audience of national and international scientists and professionals. The results are available on www.wateetnederland.nl. Results on the quantities of nutrients that the Dutch ingest will be published later in 2023., De Nationale Voedselconsumptiepeiling 2019-2021 (VCP(Voedselconsumptiepeiling)) laat zien hoeveel en wat mensen in Nederland eten en drinken. De VCP maakt ook duidelijk of zij de richtlijnen Goede voeding volgen en wat daarin is veranderd sinds de vorige peilingen in 2012-2016 en 2007-2010. De afgelopen jaren zijn Nederlanders gezonder gaan eten. Dat komt onder andere omdat ze meer plantaardige producten zoals groente, fruit, ongezouten noten en peulvruchten eten. Ook eten ze minder rood en bewerkt vlees en drinken ze minder suikerhoudende dranken. De meeste verbeteringen zijn te zien bij zowel de volwassenen als de kinderen. Verder zijn mensen meer voedingssupplementen gaan gebruiken, zoals vitamine D. Toch eten de meeste Nederlanders niet volgens de Richtlijnen Goede voeding. Over het algemeen volgen vrouwen, 65-plussers en hoger opgeleiden beter de Richtlijnen voor gezonde voeding dan mannen, jongvolwassenen en lager opgeleiden. Deze richtlijnen zijn de basis voor de Schijf van Vijf van het Voedingscentrum. Een gezondere voeding kan helpen om overgewicht en chronische ziekten als hart- en vaatziekten te voorkomen. Het RIVM bracht dit keer het voedingspatroon met ruim 3500 kinderen en volwassenen in kaart. Met deze gegevens kunnen beleidsmakers en professionals werken aan een gezond en duurzaam voedingspatroon, productinnovatie, voorlichting en onderzoek. Dit rapport beschrijft en bediscussieert de onderzoeksmethode en resultaten in detail. Het is bedoeld voor (inter)nationale wetenschappers en professionals. De resultaten zijn eerder al gepubliceerd op www.wateetnederland.nl(externe link). De resultaten over hoeveel voedingsstoffen mensen binnenkrijgen verschijnen later in 2023.

Published
2023

36. Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trial

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), CTI Leusen, Cancer, CTM & Statistical consultation, CTI Research, CTI Bont, Child Health, Infectiezieken, Longziekten patientenzorg, Arts-assistenten Kinderen, MS Neonatologie, PMC Medisch specialisten, Brain, Regenerative Medicine and Stem Cells, MMB Medische Staf, Narsyn Study Group, Infectieziekten onderzoek1 (Bont), Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), CTI Leusen, Cancer, CTM & Statistical consultation, CTI Research, CTI Bont, Child Health, Infectiezieken, Longziekten patientenzorg, Arts-assistenten Kinderen, MS Neonatologie, PMC Medisch specialisten, Brain, Regenerative Medicine and Stem Cells, MMB Medische Staf, and Narsyn Study Group

Published
2023

37. Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial

Author

Opleiding Neurologie, Projectafdeling CVZ, MMB opleiding Arts microbioloog, Infection & Immunity, MS Radiologie, Brain, Circulatory Health, CTM & Statistical consultation, Translational Neuroscience, Cancer, Neurologen, Koopman, Inez, Tack, Reinier Wp, Wunderink, Herman F, Bruns, Anke Hw, van der Schaaf, Irene C, Cianci, Daniela, Gelderman, Kyra A, van de Ridder, Inge M, Hol, Elly M, Rinkel, Gabriel Je, Vergouwen, Mervyn DI, Opleiding Neurologie, Projectafdeling CVZ, MMB opleiding Arts microbioloog, Infection & Immunity, MS Radiologie, Brain, Circulatory Health, CTM & Statistical consultation, Translational Neuroscience, Cancer, Neurologen, Koopman, Inez, Tack, Reinier Wp, Wunderink, Herman F, Bruns, Anke Hw, van der Schaaf, Irene C, Cianci, Daniela, Gelderman, Kyra A, van de Ridder, Inge M, Hol, Elly M, Rinkel, Gabriel Je, and Vergouwen, Mervyn DI

Published
2023

39. COVID-19 Vaccine Safety Monitoring Studies in Low- and Middle-Income Countries (LMICs)-A Systematic Review of Study Designs and Methods

Author

Data Science & Biostatistiek, RWE/Causal inference, Child Health, CTM & Statistical consultation, Cancer, Sisay, Malede Mequanent, Montesinos-Guevara, Camila, Osman, Alhadi Khogali, Saraswati, Putri Widi, Tilahun, Binyam, Ayele, Tadesse Awoke, Ahmadizar, Fariba, Durán, Carlos E, Sturkenboom, Miriam C J M, van de Ven, Peter, Weibel, Daniel, Data Science & Biostatistiek, RWE/Causal inference, Child Health, CTM & Statistical consultation, Cancer, Sisay, Malede Mequanent, Montesinos-Guevara, Camila, Osman, Alhadi Khogali, Saraswati, Putri Widi, Tilahun, Binyam, Ayele, Tadesse Awoke, Ahmadizar, Fariba, Durán, Carlos E, Sturkenboom, Miriam C J M, van de Ven, Peter, and Weibel, Daniel

Published
2023

40. The RISE study protocol: resilience impacted by positive stressful events for people with cystic fibrosis

Author

Longziekten onderzoek 1, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Sociale Pediatrie patientenzorg, van der Heijden, Els, van den Bor, Rutger M, van der Ent, Cornelis K, Nijhof, Sanne L, van der Laan, Sabine E I, Longziekten onderzoek 1, CTM & Statistical consultation, Circulatory Health, JC onderzoeksprogramma Methodologie, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Sociale Pediatrie patientenzorg, van der Heijden, Els, van den Bor, Rutger M, van der Ent, Cornelis K, Nijhof, Sanne L, and van der Laan, Sabine E I

Published
2023

41. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study)

Author

MS Medische Oncologie, CTM & Statistical consultation, Cancer, HEE, Kistemaker, K. R.J., de Graeff, A., Crul, M., de Klerk, G., van de Ven, P. M., van der Meulen, M. P., van Zuylen, L., Steegers, M. A.H., MS Medische Oncologie, CTM & Statistical consultation, Cancer, HEE, Kistemaker, K. R.J., de Graeff, A., Crul, M., de Klerk, G., van de Ven, P. M., van der Meulen, M. P., van Zuylen, L., and Steegers, M. A.H.

Published
2023

42. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study

Author

Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, CTI Bont, RESCEU Investigators, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, CTI Bont, and RESCEU Investigators

Published
2023

43. Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, Endocrinologie onderzoek, Cancer, MS Orthopaedie Algemeen, CTM & Statistical consultation, CTI Bont, Child Health, RSV GOLD Study Group, Infectieziekten onderzoek1 (Bont), Infection & Immunity, Endocrinologie onderzoek, Cancer, MS Orthopaedie Algemeen, CTM & Statistical consultation, CTI Bont, Child Health, and RSV GOLD Study Group

Published
2023

44. Global impacts of COVID-19 on lifestyles and health and preparation preferences: An international survey of 30 countries.

Author

Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Man Ho, M, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, Youssef, N, Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Man Ho, M, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, and Youssef, N

Abstract

BACKGROUND: The health area being greatest impacted by coronavirus disease 2019 (COVID-19) and residents' perspective to better prepare for future pandemic remain unknown. We aimed to assess and make cross-country and cross-region comparisons of the global impacts of COVID-19 and preparation preferences of pandemic. METHODS: We recruited adults in 30 countries covering all World Health Organization (WHO) regions from July 2020 to August 2021. 5 Likert-point scales were used to measure their perceived change in 32 aspects due to COVID-19 (-2 = substantially reduced to 2 = substantially increased) and perceived importance of 13 preparations (1 = not important to 5 = extremely important). Samples were stratified by age and gender in the corresponding countries. Multidimensional preference analysis displays disparities between 30 countries, WHO regions, economic development levels, and COVID-19 severity levels. RESULTS: 16 512 adults participated, with 10 351 females. Among 32 aspects of impact, the most affected were having a meal at home (mean (m) = 0.84, standard error (SE) = 0.01), cooking at home (m = 0.78, SE = 0.01), social activities (m = -0.68, SE = 0.01), duration of screen time (m = 0.67, SE = 0.01), and duration of sitting (m = 0.59, SE = 0.01). Alcohol (m = -0.36, SE = 0.01) and tobacco (m = -0.38, SE = 0.01) consumption declined moderately. Among 13 preparations, respondents rated medicine delivery (m = 3.50, SE = 0.01), getting prescribed medicine in a hospital visit / follow-up in a community pharmacy (m = 3.37, SE = 0.01), and online shopping (m = 3.33, SE = 0.02) as the most important. The multidimensional preference analysis showed the European Region, Region of the Americas, Western Pacific Region and countries with a high-income level or medium to high COVID-19 severity were more adversely impacted on sitting and screen time duration and social activities, whereas other regions and countries experienced more cooking and eating at home. Countries wit

Published
2023

45. Key lifestyles and interim health outcomes for effective interventions in general populations: A network analysis of a large international observational study.

Author

Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Ho, MM, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, Youssef, N, Li, J, Fong, DYT, Lok, KYW, Wong, JYH, Ho, MM, Choi, EPH, Pandian, V, Davidson, PM, Duan, W, Tarrant, M, Lee, JJ, Lin, C-C, Akingbade, O, Alabdulwahhab, KM, Ahmad, MS, Alboraie, M, Alzahrani, MA, Bilimale, AS, Boonpatcharanon, S, Byiringiro, S, Hasan, MKC, Schettini, LC, Corzo, W, De Leon, JM, De Leon, AS, Deek, H, Efficace, F, El Nayal, MA, El-Raey, F, Ensaldo-Carrasco, E, Escotorin, P, Fadodun, OA, Fawole, IO, Goh, Y-SS, Irawan, D, Khan, NE, Koirala, B, Krishna, A, Kwok, C, Le, TT, Leal, DG, Lezana-Fernández, MÁ, Manirambona, E, Mantoani, LC, Meneses-González, F, Mohamed, IE, Mukeshimana, M, Nguyen, CTM, Nguyen, HTT, Nguyen, KT, Nguyen, ST, Nurumal, MS, Nzabonimana, A, Omer, NAMA, Ogungbe, O, Poon, ACY, Reséndiz-Rodriguez, A, Puang-Ngern, B, Sagun, CG, Shaik, RA, Shankar, NG, Sommer, K, Toro, E, Tran, HTH, Urgel, EL, Uwiringiyimana, E, Vanichbuncha, T, and Youssef, N

Abstract

BACKGROUND: The interconnected nature of lifestyles and interim health outcomes implies the presence of the central lifestyle, central interim health outcome and bridge lifestyle, which are yet to be determined. Modifying these factors holds immense potential for substantial positive changes across all aspects of health and lifestyles. We aimed to identify these factors from a pool of 18 lifestyle factors and 13 interim health outcomes while investigating potential gender and occupation differences. METHODS: An international cross-sectional study was conducted in 30 countries across six World Health Organization regions from July 2020 to August 2021, with 16 512 adults self-reporting changes in 18 lifestyle factors and 13 interim health outcomes since the pandemic. RESULTS: Three networks were computed and tested. The central variables decided by the expected influence centrality were consumption of fruits and vegetables (centrality = 0.98) jointly with less sugary drinks (centrality = 0.93) in the lifestyles network; and quality of life (centrality = 1.00) co-dominant (centrality = 1.00) with less emotional distress in the interim health outcomes network. The overall amount of exercise had the highest bridge expected influence centrality in the bridge network (centrality = 0.51). No significant differences were found in the network global strength or the centrality of the aforementioned key variables within each network between males and females or health workers and non-health workers (all P-values >0.05 after Holm-Bonferroni correction). CONCLUSIONS: Consumption of fruits and vegetables, sugary drinks, quality of life, emotional distress, and the overall amount of exercise are key intervention components for improving overall lifestyle, overall health and overall health via lifestyle in the general population, respectively. Although modifications are needed for all aspects of lifestyle and interim health outcomes, a larger allocation of resources and more intensi

Published
2023

46. Characterization and Storage Stability Study of Guava and Mango Wood Smoked Induced Spiced Cultured Milk (Raita)

Author

Arghya Chaudhuri, null Aditya, Himanshu Mishra, Sachin Patidar, Hameedur Rehman, Lokesh Choudhary, and CTM Kumar

Abstract

A study was conducted to evaluate the effect of the smoking of raita with guava and mango wood on its functional properties and storage stability. The raita was smoked with guava and mango wood for 2.5, 5, 7.5, and 10 min in a closed chamber. The smoked raita was evaluated for change in titratable acidity (TA), pH, total phenolic content (TPC), antioxidant activity (DPPH), colour (L*, a*, and b*), and sensory attributes. Both guava and mango wood smoked samples didn’t show significant changes (P

Published
2022

49. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries

Author

Alia, DB, Tandili, A, Paiva, L, Wime, AD, Chantada, GL, Fandino, AC, Sgroi, M, Papyan, R, Tamamyan, G, Camuglia, JE, Gole, GA, Clark, A, Lam, GC, Elder, JE, McKenzie, JD, Staffieri, SE, Jones, MM, Manudhane, R, Sia, D, Ritter-Sovinz, P, Schwab, C, Balayeva, R, Khan, Z, Nuruddin, M, Roy, SR, Rashid, R, Sultana, S, Shakoor, SA, Naumenko, L, Zhilyaeva, K, Bartoszek, P, Brichard, BG, De Potter, P, Bio, AIA, Salas, B, Coleoni Suarez, ME, Mbumba, FB, Bonanomi, MTBC, Donato Macedo, CR, Grigorovski, NDAK, Mattosinho, CCDS, Teixeira, LF, Oscar, AH, Veleva-Krasteva, NV, Bouda, GC, Kabore, RL, Philbert, R, Evina, TGA, Nkumbe, HE, Kamsang, P, Muyen, OM, Dimaras, H, Mallipatna, A, Hamel, P, Superstein, R, Paton, KE, Strahlendorf, C, Palet, JEKK, Tyau-Tyau, H, Cavieres, I, Lopez, JP, Oporto, J, Ossandon, D, Chen, W, Xiang, D, Du, Y, Li, K, Ji, X, Tang, J, Li, C, Xu, B, Qian, J, Xue, K, Sun, X, Wang, Y-Z, Zhang, Y, Wu, S-Q, Xiao, Y, Yang, H, Ye, H, Polania, RA, Berete, RC, Couitchere, L, Peric, S, Alemany-Rubio, E, Gonzalez-Rodriguez, L, Autrata, R, Kepak, T, Pochop, P, Svojgr, K, Gregersen, PA, Urbak, SF, Montero, MM, Budiongo, A, Yanga, JM, Amani, TBK, Lukamba, RM, Numbi, MN, Calle Jara, DA, Villacis Chafla, EG, Sanchez, GL, Abouelnaga, S, Afifi, MA, Elhaddad, AM, Ali, AM, Elzembely, M, Said, AMA, Ziko, OAO, Fuentes-Alabi, SL, Goenz, MA, Eerme, K, Klett, A, Hordofa, DF, Mengesha, AA, Sherief, ST, Kivela, TT, Nummi, K, Cassoux, N, Desjardins, L, Obono-Obiang, G, Kardava, T, Khotenashvili, Z, Bechrakis, NE, Biewald, EM, Schlueter, S, Ketteler, P, Amankwaa-Frempong, D, Essuman, VA, Paintsil, V, Renner, LA, Alejos, A, Giron, A, Carreras, YA, Fu, LD, Maldonado, C, Wong, ES, Yam, JC, Csoka, M, Maka, E, Aggarwal, P, Gupta, V, Bhaduri, A, Bhattacharyya, A, Das, A, Chawla, B, Das, P, Das, S, Gupta, H, Gupta, S, Verma, N, Kaliki, S, Khetan, V, Maitra, P, Mahajan, A, Menon, V, Mishra, DKC, Palanivelu, MS, Ramanjulu, R, Mudaliar, SS, Nair, AG, Natarajan, S, Seth, R, Singh, U, Bhat, S, Dudeja, G, Tripathy, D, Akib, IMNR, Pagarra, H, Amiruddin, PO, Kuntorini, MW, Armytasari, I, Supriyadi, E, Sutyawan, IWE, Yuliawati, P, Lutfi, D, Soebagjo, HD, Rahman, A, Sitorus, RS, Victor, AA, Tehuteru, ES, Widiarti, W, Nency, YM, Faranoush, M, Mehrvar, A, Tashvighi, M, Sedaghat, A, Ghassemi, F, Khodabande, A, Abdulqader, RA, Al-Shaheen, AASM, Al Ani, MH, Haydar, H, Al-Badri, SAF, Al-Jadiry, MF, Sabhan, AH, Al-Jumaily, U, Al-Mafrachi, AARM, Al-Shammary, EH, Al-Janabi, ANH, Qadir, AO, Capra, M, Blum, S, Gomel, N, Fabian, ID, Goldberg, H, Kapelushnik, N, Madgar, S, Vishnevskia-Dai, V, Frenkel, S, Pe'er, J, Gorfine, M, Refaeli, D, Steinberg, DM, Lavy, Y, Toledano, H, Caspi, S, De Francesco, S, Hadjistilianou, T, Ida, R, Valente, P, Midena, E, Parrozzani, R, Cowan-Lyn, KE, Vaughan, LO, Suzuki, S, Mohammad, MT, Yousef, YA, Manzhuova, L, Atsiaya, R, Matende, IO, Begimkulova, AS, Makimbetov, EK, Keomisy, J, Sayalith, P, Valeina, S, Viksnins, M, Al-Haddad, CE, Saab, RH, Alsawidi, KM, Elbahi, AM, Krivaitiene, D, Tateshi, B, Randrianarisoa, HL, Raobela, L, Msukwa, G, Nyirenda, C, Hamzah, N, Teh, KH, Sylla, F, Traore, F, Cheikh, SS, Zein, E, Perez, GG, Sanchez Orozco, AJ, Ortega-Hernandez, M, Ramirez-Ortiz, MA, Chuluunbat, T, Abdallah, E, Benmiloud, S, El Kettani, A, Hessissen, L, Almeida, AA, Limbu, B, Rajkarnikar, P, Saiju, R, Moll, AC, Wijsard, MVH, Cockcroft, RL, Ng, Y, Dodgshun, AJ, Calderon-Sotelo, P, Abdullahi, SU, Hassan, S, Umar, AB, Abdulrahaman, AA, Wali, AH, Ademola-Popoola, DS, Adio, A, Aghaji, AE, Ezegwui, IR, Akinsete, A, Musa, KO, Fasina, O, Ibanga, A, Nkanga, ED, Mustapha, T, Ribadu, D, Hummelen, M, Ahmad, A, Mushtaq, A, Qayyum, S, Chaudhry, S, Fadoo, Z, Jeeva, I, Masud, S, Hamid, SA, Zia, N, Siddiqui, SN, Janjua, T, Yaqub, MA, Khaqan, HA, Quintero D, K, Yee, R, Jairaj, V, Cano, MR, Fernandez, DDPG, Diaz Coronado, RY, Zapata Lopez, AM, Garcia, JL, Ponce, J, Garcia Pacheco, HN, Pascual Morales, CR, Vasquez Anchaya, JK, Tarrillo Leiva, FF, Alcasabas, APA, Mercado, GJ, Cieslik, K, Hautz, W, Rogowska, A, Castela, G, Silva, S, Jo, DH, Kim, JH, Comsa, C, Dragomir, MD, Neroev, V, Saakyan, S, Polyakov, V, Ushakova, TL, Yarovaya, VA, Yarovoy, AA, Theophile, T, Al Mesfer, S, Maktabi, A, Al-Dahmash, SA, Alkatan, HM, Moreira, C, Roth, PAN, Ilic, VR, Nikitovic, M, Latinovic, S, Quah, B, Tan, D, Hederova, S, Husakova, K, Groznik, AL, Pompe, MT, Davidson, A, Du Bruyn, M, Du Plessis, J, Stones, DK, Geel, JA, Myezo, KH, Kruger, M, Mayet, I, Naidu, G, Naidu, N, Mustak, H, Reynders, D, Wetter, J, Alarcon Portabella, S, Martin-Begue, N, Wolley Dod, C, Balaguer, J, Barranco, H, Catala-Mora, J, Correa Llano, MG, Fernandez-Teijeiro, A, Garcia Aldana, D, Peralta Calvo, J, San Roman Pacheco, S, Gunasekera, DS, Elhassan, MMA, Mohamedani, AA, All-Eriksson, C, Bartuma, K, Popovic, MB, Munier, FL, Liu, C-H, Chiwanga, FS, Kyara, A, Mndeme, FG, Msina, MS, Scanlan, TA, Atchaneeyasakul, L-O, Buaboonnam, J, Dangboon, W, Singha, P, Hongeng, S, Kulvichit, K, Rojanaporn, D, Surukrattanaskul, S, Wangtiraumnuay, N, Wiwatwongwana, A, Wiwatwongwana, D, Wongwai, P, Sharma, MK, Guedenon, KM, Bouguila, H, Atalay, HT, Hasanreisoglu, M, Ataseven, E, Kantar, M, Gunduz, AK, Kebudi, R, Kiratli, H, Koc, I, Tuncer, S, Unal, E, Kalinaki, A, Matua, M, Waddell, K, Musika, AA, Ssali, G, Al Harby, L, Reddy, MA, Astbury, NJ, Bascaran, C, Bowman, R, Burton, MJ, Foster, A, Zondervan, M, Sagoo, MS, Bobrova, N, Sorochynska, T, Lysytsia, L, Castillo, L, Afshar, AR, Berry, JL, Kim, JW, Randhawa, JK, Binkley, E, Boldt, HC, Larson, SA, Brennan, RC, Chandramohan, A, Stacey, AW, Corson, TW, Plager, DA, Davanzo, JM, Singh, AD, Demirci, H, Ericksen, C, Magrath, GN, Gold, AS, Murray, TG, Gonzalez, E, Shah, AS, Hansen, ED, Hartnett, ME, Harbour, JW, Hubbard, GB, Uner, OE, Laurenti, KD, Mets, MB, Leverant, AA, Ramasubramanian, A, Luna-Fineman, S, Miller, A, Skalet, AH, Mruthyunjaya, P, Hassan, M, Oliver, SC, Shields, CL, Yaghy, A, Stahl, ED, Wilson, MW, Villegas, VM, Islamov, Z, Usmanov, RH, Graells, J, Romero, L, Pham, CTM, Trang, DL, Al-Hussaini, HH, Thawaba, ADM, Muma, KIM, Nyaywa, M, Alia, DB, Tandili, A, Paiva, L, Wime, AD, Chantada, GL, Fandino, AC, Sgroi, M, Papyan, R, Tamamyan, G, Camuglia, JE, Gole, GA, Clark, A, Lam, GC, Elder, JE, McKenzie, JD, Staffieri, SE, Jones, MM, Manudhane, R, Sia, D, Ritter-Sovinz, P, Schwab, C, Balayeva, R, Khan, Z, Nuruddin, M, Roy, SR, Rashid, R, Sultana, S, Shakoor, SA, Naumenko, L, Zhilyaeva, K, Bartoszek, P, Brichard, BG, De Potter, P, Bio, AIA, Salas, B, Coleoni Suarez, ME, Mbumba, FB, Bonanomi, MTBC, Donato Macedo, CR, Grigorovski, NDAK, Mattosinho, CCDS, Teixeira, LF, Oscar, AH, Veleva-Krasteva, NV, Bouda, GC, Kabore, RL, Philbert, R, Evina, TGA, Nkumbe, HE, Kamsang, P, Muyen, OM, Dimaras, H, Mallipatna, A, Hamel, P, Superstein, R, Paton, KE, Strahlendorf, C, Palet, JEKK, Tyau-Tyau, H, Cavieres, I, Lopez, JP, Oporto, J, Ossandon, D, Chen, W, Xiang, D, Du, Y, Li, K, Ji, X, Tang, J, Li, C, Xu, B, Qian, J, Xue, K, Sun, X, Wang, Y-Z, Zhang, Y, Wu, S-Q, Xiao, Y, Yang, H, Ye, H, Polania, RA, Berete, RC, Couitchere, L, Peric, S, Alemany-Rubio, E, Gonzalez-Rodriguez, L, Autrata, R, Kepak, T, Pochop, P, Svojgr, K, Gregersen, PA, Urbak, SF, Montero, MM, Budiongo, A, Yanga, JM, Amani, TBK, Lukamba, RM, Numbi, MN, Calle Jara, DA, Villacis Chafla, EG, Sanchez, GL, Abouelnaga, S, Afifi, MA, Elhaddad, AM, Ali, AM, Elzembely, M, Said, AMA, Ziko, OAO, Fuentes-Alabi, SL, Goenz, MA, Eerme, K, Klett, A, Hordofa, DF, Mengesha, AA, Sherief, ST, Kivela, TT, Nummi, K, Cassoux, N, Desjardins, L, Obono-Obiang, G, Kardava, T, Khotenashvili, Z, Bechrakis, NE, Biewald, EM, Schlueter, S, Ketteler, P, Amankwaa-Frempong, D, Essuman, VA, Paintsil, V, Renner, LA, Alejos, A, Giron, A, Carreras, YA, Fu, LD, Maldonado, C, Wong, ES, Yam, JC, Csoka, M, Maka, E, Aggarwal, P, Gupta, V, Bhaduri, A, Bhattacharyya, A, Das, A, Chawla, B, Das, P, Das, S, Gupta, H, Gupta, S, Verma, N, Kaliki, S, Khetan, V, Maitra, P, Mahajan, A, Menon, V, Mishra, DKC, Palanivelu, MS, Ramanjulu, R, Mudaliar, SS, Nair, AG, Natarajan, S, Seth, R, Singh, U, Bhat, S, Dudeja, G, Tripathy, D, Akib, IMNR, Pagarra, H, Amiruddin, PO, Kuntorini, MW, Armytasari, I, Supriyadi, E, Sutyawan, IWE, Yuliawati, P, Lutfi, D, Soebagjo, HD, Rahman, A, Sitorus, RS, Victor, AA, Tehuteru, ES, Widiarti, W, Nency, YM, Faranoush, M, Mehrvar, A, Tashvighi, M, Sedaghat, A, Ghassemi, F, Khodabande, A, Abdulqader, RA, Al-Shaheen, AASM, Al Ani, MH, Haydar, H, Al-Badri, SAF, Al-Jadiry, MF, Sabhan, AH, Al-Jumaily, U, Al-Mafrachi, AARM, Al-Shammary, EH, Al-Janabi, ANH, Qadir, AO, Capra, M, Blum, S, Gomel, N, Fabian, ID, Goldberg, H, Kapelushnik, N, Madgar, S, Vishnevskia-Dai, V, Frenkel, S, Pe'er, J, Gorfine, M, Refaeli, D, Steinberg, DM, Lavy, Y, Toledano, H, Caspi, S, De Francesco, S, Hadjistilianou, T, Ida, R, Valente, P, Midena, E, Parrozzani, R, Cowan-Lyn, KE, Vaughan, LO, Suzuki, S, Mohammad, MT, Yousef, YA, Manzhuova, L, Atsiaya, R, Matende, IO, Begimkulova, AS, Makimbetov, EK, Keomisy, J, Sayalith, P, Valeina, S, Viksnins, M, Al-Haddad, CE, Saab, RH, Alsawidi, KM, Elbahi, AM, Krivaitiene, D, Tateshi, B, Randrianarisoa, HL, Raobela, L, Msukwa, G, Nyirenda, C, Hamzah, N, Teh, KH, Sylla, F, Traore, F, Cheikh, SS, Zein, E, Perez, GG, Sanchez Orozco, AJ, Ortega-Hernandez, M, Ramirez-Ortiz, MA, Chuluunbat, T, Abdallah, E, Benmiloud, S, El Kettani, A, Hessissen, L, Almeida, AA, Limbu, B, Rajkarnikar, P, Saiju, R, Moll, AC, Wijsard, MVH, Cockcroft, RL, Ng, Y, Dodgshun, AJ, Calderon-Sotelo, P, Abdullahi, SU, Hassan, S, Umar, AB, Abdulrahaman, AA, Wali, AH, Ademola-Popoola, DS, Adio, A, Aghaji, AE, Ezegwui, IR, Akinsete, A, Musa, KO, Fasina, O, Ibanga, A, Nkanga, ED, Mustapha, T, Ribadu, D, Hummelen, M, Ahmad, A, Mushtaq, A, Qayyum, S, Chaudhry, S, Fadoo, Z, Jeeva, I, Masud, S, Hamid, SA, Zia, N, Siddiqui, SN, Janjua, T, Yaqub, MA, Khaqan, HA, Quintero D, K, Yee, R, Jairaj, V, Cano, MR, Fernandez, DDPG, Diaz Coronado, RY, Zapata Lopez, AM, Garcia, JL, Ponce, J, Garcia Pacheco, HN, Pascual Morales, CR, Vasquez Anchaya, JK, Tarrillo Leiva, FF, Alcasabas, APA, Mercado, GJ, Cieslik, K, Hautz, W, Rogowska, A, Castela, G, Silva, S, Jo, DH, Kim, JH, Comsa, C, Dragomir, MD, Neroev, V, Saakyan, S, Polyakov, V, Ushakova, TL, Yarovaya, VA, Yarovoy, AA, Theophile, T, Al Mesfer, S, Maktabi, A, Al-Dahmash, SA, Alkatan, HM, Moreira, C, Roth, PAN, Ilic, VR, Nikitovic, M, Latinovic, S, Quah, B, Tan, D, Hederova, S, Husakova, K, Groznik, AL, Pompe, MT, Davidson, A, Du Bruyn, M, Du Plessis, J, Stones, DK, Geel, JA, Myezo, KH, Kruger, M, Mayet, I, Naidu, G, Naidu, N, Mustak, H, Reynders, D, Wetter, J, Alarcon Portabella, S, Martin-Begue, N, Wolley Dod, C, Balaguer, J, Barranco, H, Catala-Mora, J, Correa Llano, MG, Fernandez-Teijeiro, A, Garcia Aldana, D, Peralta Calvo, J, San Roman Pacheco, S, Gunasekera, DS, Elhassan, MMA, Mohamedani, AA, All-Eriksson, C, Bartuma, K, Popovic, MB, Munier, FL, Liu, C-H, Chiwanga, FS, Kyara, A, Mndeme, FG, Msina, MS, Scanlan, TA, Atchaneeyasakul, L-O, Buaboonnam, J, Dangboon, W, Singha, P, Hongeng, S, Kulvichit, K, Rojanaporn, D, Surukrattanaskul, S, Wangtiraumnuay, N, Wiwatwongwana, A, Wiwatwongwana, D, Wongwai, P, Sharma, MK, Guedenon, KM, Bouguila, H, Atalay, HT, Hasanreisoglu, M, Ataseven, E, Kantar, M, Gunduz, AK, Kebudi, R, Kiratli, H, Koc, I, Tuncer, S, Unal, E, Kalinaki, A, Matua, M, Waddell, K, Musika, AA, Ssali, G, Al Harby, L, Reddy, MA, Astbury, NJ, Bascaran, C, Bowman, R, Burton, MJ, Foster, A, Zondervan, M, Sagoo, MS, Bobrova, N, Sorochynska, T, Lysytsia, L, Castillo, L, Afshar, AR, Berry, JL, Kim, JW, Randhawa, JK, Binkley, E, Boldt, HC, Larson, SA, Brennan, RC, Chandramohan, A, Stacey, AW, Corson, TW, Plager, DA, Davanzo, JM, Singh, AD, Demirci, H, Ericksen, C, Magrath, GN, Gold, AS, Murray, TG, Gonzalez, E, Shah, AS, Hansen, ED, Hartnett, ME, Harbour, JW, Hubbard, GB, Uner, OE, Laurenti, KD, Mets, MB, Leverant, AA, Ramasubramanian, A, Luna-Fineman, S, Miller, A, Skalet, AH, Mruthyunjaya, P, Hassan, M, Oliver, SC, Shields, CL, Yaghy, A, Stahl, ED, Wilson, MW, Villegas, VM, Islamov, Z, Usmanov, RH, Graells, J, Romero, L, Pham, CTM, Trang, DL, Al-Hussaini, HH, Thawaba, ADM, Muma, KIM, and Nyaywa, M

Abstract

BACKGROUND: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS: We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS: The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0-36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8-100·0) for children from high-income countries, 91·2% (89·5-93·0) for children from upper-middle-income countries, 80·3% (78·3-82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76-50·00), cT4 advanced tumour compared to

Published
2022

50. Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials

Author

Datamanagement 1, Research UMC Utrecht, CTM & Statistical consultation, MS Verloskunde, Child Health, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., Li, Wentao, Datamanagement 1, Research UMC Utrecht, CTM & Statistical consultation, MS Verloskunde, Child Health, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., and Li, Wentao

Published
2022

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