3,268 results on '"CREA, F."'
Search Results
2. Landfill leachate from Municipal Solid Waste: Multi-technique approach for its fine characterization and determination of the thermodynamic and sequestering properties towards some toxic metals
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Irto, A., Crea, F., Alessandrello, C., De Stefano, C., Somma, R., Zaffino, G., Zaccaro, S., Papanikolaou, G., and Cigala, R.M.
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- 2024
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3. On the role of alkali content on one-part alkali activated slag pastes produced with tri- blend solid activators
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Coffetti, D., Candamano, S., Crea, F., and Coppola, L.
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- 2023
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4. Preparation of foamed and unfoamed geopolymer/NaX zeolite/activated carbon composites for CO2 adsorption
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Candamano, S., Policicchio, A., Conte, G., Abarca, R., Algieri, C., Chakraborty, S., Curcio, S., Calabrò, V., Crea, F., and Agostino, R.G.
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- 2022
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5. Long-term risk assessment in athletes with ventricular arrhythmias: the key roles of arrhythmia morphology, complexity, and substrate
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Compagnucci, P, primary, Casella, M, additional, Narducci, M L, additional, Conte, E, additional, Cammarano, M, additional, Pelargonio, G, additional, Andreini, D, additional, Palmieri, V, additional, Lo Russo, G, additional, Pontone, G, additional, Natale, A, additional, Tondo, C, additional, Crea, F, additional, Zeppilli, P, additional, and Dello Russo, A, additional
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- 2024
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6. Arrhythmic mitral valve prolapse with versus without prior mitral valve repair: clinical profiles, electrophysiological substrates, and long-term clinical outcomes
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Compagnucci, P, primary, Casella, M, additional, Narducci, M L, additional, Mohanty, S, additional, Cipolletta, L, additional, Parisi, Q, additional, De Francesco, L, additional, Lofiego, C, additional, Volpato, G, additional, Perna, G P, additional, Pelargonio, G, additional, Di Eusanio, M, additional, Crea, F, additional, Natale, A, additional, and Dello Russo, A, additional
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- 2024
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7. Coronary plaque instability assessed by positron emission tomography and optical coherence tomography
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Galiuto, L., Leccisotti, L., Locorotondo, G., Porto, I., Burzotta, F., Trani, C., Niccoli, G., Leone, A. M., Danza, M. L., Melita, V., Fedele, E., Stefanelli, A., Giordano, A., and Crea, F.
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- 2021
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8. The potential impact of acute coronary syndromes on automatic sensing system in Subcutaneous-ICDs
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Narducci, M.L., Scacciavillani, R., Pinnacchio, G., Bencardino, G., Perna, F., Comerci, G., Campisi, M., Ceccarelli, I., Pavone, C., Spera, F., Bisignani, A., Crea, F., and Pelargonio, G.
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- 2021
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9. Influence of acrylic latex and pre-treated hemp fibers on cement based mortar properties
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Candamano, S., Crea, F., Coppola, L., De Luca, P., and Coffetti, D.
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- 2021
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10. From angiotensin-converting enzyme 2 disruption to thromboinflammatory microvascular disease: A paradigm drawn from COVID-19
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Vinci, R., Pedicino, D., Andreotti, F., Russo, G., D'Aiello, A., De Cristofaro, R., Crea, F., and Liuzzo, G.
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- 2021
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11. Efficacy of “Physiology-Guided PCI” Using Pressure Catheter in Comparison to Conventional Pressure Wires: A Multicenter Analysis
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Anastasia, G., Galante, D., Biscaglia, S., Vergallo, Rocco, Di Giusto, F., Migliaro, S., Petrolati, E., Vicere, A., Scancarello, D., Marrone, A., Verardi, F. M., Campaniello, Giorgia, Giuliana, Chiara, Pollio Benvenuto, Ciro, Viccaro, Vincenzo, Todisco, Simona, Burzotta, Francesco, Aurigemma, Cristina, Romagnoli, E., Trani, Carlo, Crea, Filippo, Porto, Italo, Campo, G., Leone, Antonio Maria, Vergallo R., Campaniello G., Giuliana C., Pollio Benvenuto C., Viccaro V., Todisco S., Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Trani C. (ORCID:0000-0001-9777-013X), Crea F. (ORCID:0000-0001-9404-8846), Porto I. (ORCID:0000-0002-9854-5046), Leone A. M. (ORCID:0000-0002-1276-9883), Anastasia, G., Galante, D., Biscaglia, S., Vergallo, Rocco, Di Giusto, F., Migliaro, S., Petrolati, E., Vicere, A., Scancarello, D., Marrone, A., Verardi, F. M., Campaniello, Giorgia, Giuliana, Chiara, Pollio Benvenuto, Ciro, Viccaro, Vincenzo, Todisco, Simona, Burzotta, Francesco, Aurigemma, Cristina, Romagnoli, E., Trani, Carlo, Crea, Filippo, Porto, Italo, Campo, G., Leone, Antonio Maria, Vergallo R., Campaniello G., Giuliana C., Pollio Benvenuto C., Viccaro V., Todisco S., Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Trani C. (ORCID:0000-0001-9777-013X), Crea F. (ORCID:0000-0001-9404-8846), Porto I. (ORCID:0000-0002-9854-5046), and Leone A. M. (ORCID:0000-0002-1276-9883)
- Abstract
N/A
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- 2024
12. The combined use of admixtures for shrinkage reduction in one-part alkali activated slag-based mortars and pastes
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Coppola, L., Coffetti, D., Crotti, E., Candamano, S., Crea, F., Gazzaniga, G., and Pastore, T.
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- 2020
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13. Qualification Activities for the DTT Divertor
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Giorgetti, F., primary, Roccella, S., additional, Crea, F., additional, Dose, G., additional, Luca, R. De, additional, Sano, G. De, additional, Lorusso, P., additional, Satriano, A., additional, Riccardi, B., additional, Polli, G. M., additional, and Neu, R., additional
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- 2024
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14. Heart failure management guided by remote multiparameter monitoring: A meta-analysis
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Zito, A, Restivo, A, Ciliberti, G, Laborante, R, Princi, G, Romiti, G, Galli, M, Rodolico, D, Bianchini, E, Cappannoli, L, D'Oria, M, Trani, C, Burzotta, F, Cesario, A, Savarese, G, Crea, F, D'Amario, D, Zito A., Restivo A., Ciliberti G., Laborante R., Princi G., Romiti G. F., Galli M., Rodolico D., Bianchini E., Cappannoli L., D'Oria M., Trani C., Burzotta F., Cesario A., Savarese G., Crea F., D'Amario D., Zito, A, Restivo, A, Ciliberti, G, Laborante, R, Princi, G, Romiti, G, Galli, M, Rodolico, D, Bianchini, E, Cappannoli, L, D'Oria, M, Trani, C, Burzotta, F, Cesario, A, Savarese, G, Crea, F, D'Amario, D, Zito A., Restivo A., Ciliberti G., Laborante R., Princi G., Romiti G. F., Galli M., Rodolico D., Bianchini E., Cappannoli L., D'Oria M., Trani C., Burzotta F., Cesario A., Savarese G., Crea F., and D'Amario D.
- Abstract
Background: Several implant-based remote monitoring strategies are currently tested to optimize heart failure (HF) management by anticipating clinical decompensation and preventing hospitalization. Among these solutions, the modern implantable cardioverter-defibrillator and cardiac resynchronization therapy devices have been equipped with sensors allowing continuous monitoring of multiple preclinical markers of worsening HF, including factors of autonomic adaptation, patient activity, and intrathoracic impedance. Objectives: We aimed to assess whether implant-based multiparameter remote monitoring strategy for guided HF management improves clinical outcomes when compared to standard clinical care. Methods: A systematic literature research for randomized controlled trials (RCTs) comparing multiparameter-guided HF management versus standard of care was performed on PubMed, Embase, and CENTRAL databases. Incidence rate ratios (IRRs) and associated 95% confidence intervals (CIs) were calculated using the Poisson regression model with random study effects. The primary outcome was a composite of all-cause death and HF hospitalization events, whereas secondary endpoints included the individual components of the primary outcome. Results: Our meta-analysis included 6 RCTs, amounting to a total of 4869 patients with an average follow-up time of 18 months. Compared with standard clinical management, the multiparameter-guided strategy reduced the risk of the primary composite outcome (IRR 0.83, 95%CI 0.71–0.99), driven by statistically significant effect on both HF hospitalization events (IRR 0.75, 95%CI 0.61–0.93) and all-cause death (IRR 0.80, 95%CI 0.66–0.96). Conclusion: Implant-based multiparameter remote monitoring strategy for guided HF management is associated with significant benefit on clinical outcomes compared to standard clinical care, providing a benefit on both hospitalization events and all-cause death.
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- 2023
15. Impact on clinical outcome of ventricular arrhythmias in patients undergoing transcatheter aortic valve implantation (TAVI)
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Cambise, N, primary, Gnan, E, additional, Tremamunno, S, additional, Telesca, A, additional, Belmusto, A, additional, Gentile, G, additional, De Vita, A, additional, Aurigemma, C, additional, Burzotta, F, additional, Trani, C, additional, Crea, F, additional, and Lanza, G A, additional
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- 2023
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16. Biological profiling in the spectrum of acute coronary syndrome: characterizing patients from MINOCA to NSTEMI with different features of the culprit plaque
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D'aiello, A, primary, Pedicino, D, additional, Bonanni, A, additional, Vinci, R, additional, Severino, A, additional, Ponzo, M, additional, Conte, C, additional, Cribari, F, additional, Filomia, S, additional, Brecciaroli, M, additional, Grimaldi, M C, additional, Montone, R A, additional, Massetti, M, additional, Crea, F, additional, and Liuzzo, G, additional
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- 2023
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17. Feasibility, safety and prognostic relevance of acetylcholine provocative testing in patients with myocardial bridge: a prespecified analysis of the RIALTO Registry
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D'amario, D, primary, Ciliberti, G, additional, Laborante, R, additional, Rizzo, G, additional, Casamassima, F, additional, Restivo, A, additional, Trani, C, additional, Burzotta, F, additional, Romagnoli, E, additional, Leone, A M, additional, and Crea, F, additional
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- 2023
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18. Transcatheter versus surgical aortic valve replacement in patients with aortic stenosis: molecular pathways and correlation with clinical and echocardiographic parameters
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Pedicino, D, primary, D'aiello, A, additional, Bonanni, A, additional, Vinci, R, additional, Severino, A, additional, Pasquini, A, additional, Burzotta, F, additional, Trani, C, additional, Ciampi, P, additional, Aurigemma, C, additional, Bruno, P, additional, Russo, G, additional, Massetti, M, additional, Crea, F, additional, and Liuzzo, G, additional
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- 2023
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19. Relation between high-sensitivity troponin i serum levels and myocardial ischemia in patients with suspected chronic coronary syndrome: the RESET-MI study
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De Vita, A, primary, Bruno, I, additional, Baroni, S, additional, Moretti, G, additional, Tempestini, F, additional, Telesca, A, additional, Tremamunno, S, additional, Felici, T, additional, Verrillo, A, additional, Lamendola, P, additional, Cambise, N, additional, Liuzzo, G, additional, Crea, F, additional, Giordano, A, additional, and Lanza, G A, additional
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- 2023
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20. Artificial intelligence empowered digital platform to support patients with heart failure (AZIMUTH platform)
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D'amario, D, primary, Restivo, A, additional, Laborante, R, additional, Paglianiti, A, additional, Casamassima, F, additional, Patarnello, S, additional, Cesario, A, additional, Luraschi, A, additional, and Crea, F, additional
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- 2023
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21. Ticagrelor induces ischaemic preconditioning in coronary artery disease
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D'amario, D, primary, Restivo, A, additional, Galli, M, additional, Laborante, R, additional, Leone, A M, additional, Trani, C, additional, Romagnoli, E, additional, Burzotta, F, additional, and Crea, F, additional
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- 2023
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22. Safety, usability, and performance of a wireless left atrial pressure monitoring system in patients with heart failure: the VECTOR-HF trial (final results)
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D'amario, D, primary, Restivo, A, additional, Merkin, D, additional, Crea, F, additional, Ince, H, additional, Sievert, H, additional, Schaefer, U, additional, Trani, C, additional, Di Mario, C, additional, Anker, S, additional, and Perl, L, additional
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- 2023
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23. Ticagrelor and preconditioning in patients with stable coronary artery disease (TAPER-S): a randomized pilot clinical trial
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D’Amario, D., Restivo, A., Leone, A. M., Vergallo, R., Migliaro, S., Canonico, F., Galli, M., Trani, C., Burzotta, F., Aurigemma, C., Niccoli, G., Buffon, A., Montone, R. A., Flex, A., Franceschi, F., Tinelli, G., Limbruno, U., Francese, F., Ceccarelli, I., Borovac, J. A., Porto, I., and Crea, F.
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- 2020
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24. Molecular Hallmarks of Ischemia with Non-Obstructive Coronary Arteries: The “INOCA versus Obstructive CCS” Challenge
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Bonanni, A., D'aiello, A., Pedicino, D., Di Sario, M., Vinci, R., Ponzo, M., Ciampi, P., Curto, D. L., Conte, C., Cribari, F., Canonico, F., Russo, G., Montone, R. A., Trani, C., Severino, A., Crea, F., Liuzzo, G., Bonanni A., Pedicino D., Di Sario M., Vinci R., Ponzo M., Ciampi P., Conte C., Cribari F., Canonico F. (ORCID:0000-0001-6936-4548), Montone R. A., Trani C. (ORCID:0000-0001-9777-013X), Severino A., Crea F. (ORCID:0000-0001-9404-8846), Liuzzo G. (ORCID:0000-0002-5714-0907), Bonanni, A., D'aiello, A., Pedicino, D., Di Sario, M., Vinci, R., Ponzo, M., Ciampi, P., Curto, D. L., Conte, C., Cribari, F., Canonico, F., Russo, G., Montone, R. A., Trani, C., Severino, A., Crea, F., Liuzzo, G., Bonanni A., Pedicino D., Di Sario M., Vinci R., Ponzo M., Ciampi P., Conte C., Cribari F., Canonico F. (ORCID:0000-0001-6936-4548), Montone R. A., Trani C. (ORCID:0000-0001-9777-013X), Severino A., Crea F. (ORCID:0000-0001-9404-8846), and Liuzzo G. (ORCID:0000-0002-5714-0907)
- Abstract
Up to 4 million patients with signs of myocardial ischemia have no obstructive coronary artery disease (CAD). The absence of precise guidelines for diagnosis and treatment in non-obstructive CAD encourages the scientific community to fill the gap knowledge, to provide non-invasive and less expensive diagnostic tools. The aim of our study was to explore the biological profile of Ischemia with Non-Obstructive Coronary Arteries (INOCA) patients with microvascular dysfunction compared to patients presenting with obstructive chronic coronary syndrome (ObCCS) in order to find specific hallmarks of each clinical condition. We performed a gene expression array from peripheral blood mononuclear cells (PBMCs) isolated from INOCA (n = 18) and ObCCS (n = 20) patients. Our results showed a significantly reduced gene expression of molecules involved in cell adhesion, signaling, vascular motion, and inflammation in INOCA as compared to the ObCCS group. In detail, we found lower expression of Platelet and Endothelial Cell Adhesion Molecule 1 (CD31, p < 0.0001), Intercellular Adhesion Molecule-1 (ICAM1, p = 0.0004), Tumor Necrosis Factor (TNF p = 0.0003), Transferrin Receptor (TFRC, p = 0.002), and Vascular Endothelial Growth Factor A (VEGFA, p = 0.0006) in the INOCA group compared with ObCCS. Meanwhile, we observed an increased expression of Hyaluronidase (HYAL2, p < 0.0001) in INOCA patients in comparison to ObCCS. The distinct expression of molecular biomarkers might allow an early and non-invasive differential diagnosis between ObCCS and INOCA, improving clinical management and treatment options, in the era of personalized medicine.
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- 2022
25. Air Pollution and Coronary Plaque Vulnerability and Instability: An Optical Coherence Tomography Study
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Montone, R. A., Camilli, M., Russo, M., Termite, C., La Vecchia, G., Iannaccone, G., Rinaldi, R., Gurgoglione, F., Del Buono, M. G., Sanna, T., Trani, C., Liuzzo, G., Crea, F., Niccoli, G., Montone R. A., Camilli M., Russo M., La Vecchia G., Iannaccone G., Rinaldi R., Gurgoglione F., Del Buono M. G., Sanna T. (ORCID:0000-0002-5760-6885), Trani C. (ORCID:0000-0001-9777-013X), Liuzzo G. (ORCID:0000-0002-5714-0907), Crea F. (ORCID:0000-0001-9404-8846), Niccoli G. (ORCID:0000-0002-3187-6262), Montone, R. A., Camilli, M., Russo, M., Termite, C., La Vecchia, G., Iannaccone, G., Rinaldi, R., Gurgoglione, F., Del Buono, M. G., Sanna, T., Trani, C., Liuzzo, G., Crea, F., Niccoli, G., Montone R. A., Camilli M., Russo M., La Vecchia G., Iannaccone G., Rinaldi R., Gurgoglione F., Del Buono M. G., Sanna T. (ORCID:0000-0002-5760-6885), Trani C. (ORCID:0000-0001-9777-013X), Liuzzo G. (ORCID:0000-0002-5714-0907), Crea F. (ORCID:0000-0001-9404-8846), and Niccoli G. (ORCID:0000-0002-3187-6262)
- Abstract
Objectives: We assessed the relationship between exposure to air pollutants and mechanisms of coronary instability evaluated by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). Background: Air pollution is an emerging key player in determining the residual risk of coronary events. However, pathophysiological mechanisms linking air pollution and coronary events have been not adequately investigated. Methods: Patients with ACS undergoing OCT imaging were retrospectively selected. Mechanism of culprit lesion instability was classified as plaque rupture (PR) or intact fibrous cap (IFC) by OCT, and the presence of macrophage infiltrates (MØI) and thin-cap fibroatheroma (TCFA) at the culprit site was also assessed. Based on each case's home address, exposure to several pollutants was evaluated, including particulate matter 2.5 (PM2.5), PM10, and carbon monoxide (CO). Only patients with >2 years of available data on air pollution exposure prior to ACS were enrolled. Results: We included 126 patients (median age: 67.0 years of age; IQR: 55.5-76.0; 97 male patients [77.0%]). Sixty-six patients (52.4%) had PR as the mechanism of plaque instability. Patients with PR were exposed to significantly higher PM2.5 levels than to IFC, and PM2.5 was independently associated with PR (odds ratio: 1.194; 95% CI: 1.036 to 1.377; P = 0.015). Moreover, exposure to higher levels of PM2.5 was independently associated with the presence of TCFA and of MØI at the culprit site. Interestingly, PM2.5, PM10, and CO levels were positively and significantly correlated with serum levels of C-reactive protein. Conclusions: We provide novel insights into the missing link between air pollution and increased risk of coronary events. In particular, exposure to higher concentrations of air pollutants is associated with the presence of vulnerable plaque features and with plaque rupture as a mechanism of coronary instability. An enhanced systemic and plaque inflammatory act
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- 2022
26. Prognosis of patients undergoing catheter ablation of arrhythmic storm in patients with and without history of previous ICD interventions
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Telesca, A, primary, Bencardino, G, additional, Scacciavillani, R, additional, Perna, F, additional, Narducci, M L, additional, Comerci, G, additional, Pinnacchio, G, additional, Spera, F R, additional, Gabrielli, F A, additional, Pelargonio, G, additional, Massetti, M, additional, and Crea, F, additional
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- 2023
- Full Text
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27. Left atrial strain analysis improves left ventricular filling pressures non-invasive estimation in the acute phase of Takotsubo syndrome
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Iannaccone, G, Graziani, F, Del Buono, M, Camilli, M, Lillo, R, Caffè, A, Moroni, F, La Vecchia, G, Pedicino, D, Sanna, T, Trani, C, Lombardo, A, Lanza, G, Massetti, M, Crea, F, Montone, R, Iannaccone, Giulia, Graziani, Francesca, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Lillo, Rosa, Caffè, Andrea, Moroni, Francesco, La Vecchia, Giulia, Pedicino, Daniela, Sanna, Tommaso, Trani, Carlo, Lombardo, Antonella, Lanza, Gaetano Antonio, Massetti, Massimo, Crea, Filippo, Montone, Rocco A, Iannaccone, G, Graziani, F, Del Buono, M, Camilli, M, Lillo, R, Caffè, A, Moroni, F, La Vecchia, G, Pedicino, D, Sanna, T, Trani, C, Lombardo, A, Lanza, G, Massetti, M, Crea, F, Montone, R, Iannaccone, Giulia, Graziani, Francesca, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Lillo, Rosa, Caffè, Andrea, Moroni, Francesco, La Vecchia, Giulia, Pedicino, Daniela, Sanna, Tommaso, Trani, Carlo, Lombardo, Antonella, Lanza, Gaetano Antonio, Massetti, Massimo, Crea, Filippo, and Montone, Rocco A
- Abstract
Aims The aim of our study is to assess the ability of left atrial (LA) strain values to improve left ventricular and diastolic pressure (LVEDP) non-invasive estimation as compared with traditional echocardiographic indexes in the acute phase of Takotsubo syndrome (TTS) and to predict adverse in-hospital outcomes in this population. Methods and results Consecutive TTS patients were prospectively enrolled. Left ventricular and diastolic pressure was measured at the time of catheterization. Transthoracic echocardiography was performed within 48 h from hospital admission. In-hospital complications (acute heart failure, death from any cause, and life-threatening arrhythmias) were collected. A total of 62 patients were analysed (72.2 ± 10.1 years, female 80%) and in-hospital complications occurred in 25 (40.3%). Left ventricular and diastolic pressure mean value was 24.53 ± 7.92 mmHg. Left atrial reservoir and pump strain values presented higher correlation with LVEDP (r −0.859, P < 0.001 and r −0.848, P < 0.001, respectively) in comparison with E/e ′ ratio, left atrial volume index (LAVi), and tricuspid regurgitation (TR) peak velocity. In addition, at receiver-operating characteristic curve analysis, LA reservoir and pump strain resulted to be better predictors of LVEDP above the mean of our population [0.909 (95% CI 0.818-0.999, P < 0.001) and 0.889 (95% CI 0.789-0.988, P < 0.001)], respectively] as compared with E/e′ ratio, LAVi, and TR peak velocity. Finally, LA reservoir strain resulted to be an independent predictor of worse in-hospital outcomes, together with LVEDP and left ventricular ejection fraction (all P < 0.001). Conclusion In our study, lower LA reservoir and pump strain values were better predictors of LVEDP as compared with traditional echocardiographic indexes in the acute phase of TTS syndrome. Moreover, LA reservoir strain was an independent predict- or of adverse in-hospital outcomes.
- Published
- 2023
28. Inflammation across the spectrum of hypertrophic cardiac phenotypes
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Lillo, Rosa, Graziani, Francesca, Franceschi, Francesco, Iannaccone, Giulia, Massetti, Massimo, Olivotto, I, Crea, Filippo, Liuzzo, Giovanna, Lillo R, Graziani F (ORCID:0000-0002-4520-5689), Franceschi F (ORCID:0000-0001-6266-445X), Iannaccone G, Massetti M (ORCID:0000-0002-7100-8478), Crea F (ORCID:0000-0001-9404-8846), Liuzzo G. (ORCID:0000-0002-5714-0907), Lillo, Rosa, Graziani, Francesca, Franceschi, Francesco, Iannaccone, Giulia, Massetti, Massimo, Olivotto, I, Crea, Filippo, Liuzzo, Giovanna, Lillo R, Graziani F (ORCID:0000-0002-4520-5689), Franceschi F (ORCID:0000-0001-6266-445X), Iannaccone G, Massetti M (ORCID:0000-0002-7100-8478), Crea F (ORCID:0000-0001-9404-8846), and Liuzzo G. (ORCID:0000-0002-5714-0907)
- Abstract
The hypertrophic cardiomyopathy phenotype encompasses a heterogeneous spectrum of genetic and acquired diseases characterized by the presence of left ventricular hypertrophy in the absence of abnormal cardiac loading conditions. This "umbrella diagnosis" includes the "classic" hypertrophic cardiomyopathy (HCM), due to sarcomere protein gene mutations, and its phenocopies caused by intra- or extracellular deposits, such as Fabry disease (FD) and cardiac amyloidosis (CA). All these conditions share a wide phenotypic variability which results from the combination of genetic and environmental factors and whose pathogenic mediators are poorly understood so far. Accumulating evidence suggests that inflammation plays a critical role in a broad spectrum of cardiovascular conditions, including cardiomyopathies. Indeed, inflammation can trigger molecular pathways which contribute to cardiomyocyte hypertrophy and dysfunction, extracellular matrix accumulation, and microvascular dysfunction. Growing evidence suggests that systemic inflammation is a possible key pathophysiologic process potentially involved in the pathogenesis of cardiac disease progression, influencing the severity of the phenotype and clinical outcome, including heart failure. In this review, we summarize current knowledge regarding the prevalence, clinical significance, and potential therapeutic implications of inflammation in HCM and two of its most important phenocopies, FD and CA.
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- 2023
29. Right ventricular strain in Fabry disease: Prognostic implications
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Meucci, M. C., Lillo, Rosa, Mango, F., Lombardo, Antonella, Lanza, Gaetano Antonio, Parisi, V., Grandinetti, M., Massetti, Massimo, Ajmone Marsan, N., Crea, Filippo, Graziani, Francesca, Lillo R., Lombardo A. (ORCID:0000-0003-3162-1830), Lanza G. A. (ORCID:0000-0003-2187-6653), Massetti M. (ORCID:0000-0002-7100-8478), Crea F. (ORCID:0000-0001-9404-8846), Graziani F. (ORCID:0000-0002-4520-5689), Meucci, M. C., Lillo, Rosa, Mango, F., Lombardo, Antonella, Lanza, Gaetano Antonio, Parisi, V., Grandinetti, M., Massetti, Massimo, Ajmone Marsan, N., Crea, Filippo, Graziani, Francesca, Lillo R., Lombardo A. (ORCID:0000-0003-3162-1830), Lanza G. A. (ORCID:0000-0003-2187-6653), Massetti M. (ORCID:0000-0002-7100-8478), Crea F. (ORCID:0000-0001-9404-8846), and Graziani F. (ORCID:0000-0002-4520-5689)
- Abstract
Introduction: Left ventricular (LV) hypertrophy is the main feature of cardiac involvement in Anderson-Fabry disease (FD), but the right ventricle (RV) is also frequently affected. Previous studies failed to demonstrate an independent association between conventional parameters of RV performance and outcomes in FD. Nevertheless, if RV free wall strain (RV-FWS), assessed by 2D speckle tracking analysis, may provide a better prognostication is currently unknown. Methods: We retrospectively evaluated the association between RV-FWS and the occurrence of cardiovascular events in a cohort of 56 patients with FD. The study endpoint comprises cardiovascular mortality, severe heart failure symptoms, new-onset atrial fibrillation and major arrhythmias requiring device implantation. Results: Reduced RV-FWS, defined by values lower than 23%, was found in 25 (45%) patients. During a median follow-up of 47 months, 16 (29%) patients met the study endpoint. A ROC-curve analysis confirmed the threshold of reduced RV-FWS (<23%) as the best cut-off for predicting cardiovascular events, but with a lower power compared to left-sided parameters. On univariable Cox regression analysis, RV-FWS, expressed as continuous variable, was significantly associated with the study endpoint (HR: 0.795, 95% CI: 0.710–0.889, p < 0.001). However, RV-FWS did not retain a significant association with outcomes, after adjustment for LV global longitudinal strain or indexed left atrial volume (p = 0.340 and p = 0.289 respectively). Conclusions: RV-FWS was not independently associated with the occurrence of cardiovascular events in FD, confirming previous observations that prognosis is mainly driven by the severity of LV cardiomyopathy.
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- 2023
30. Left Ventricular-Arterial Coupling and Vascular Function in Childhood Cancer Survivors Exposed to Anthracycline Chemotherapy
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Camilli, Massimiliano, Birritella, L., Delogu, Angelica Bibiana, Lamendola, Priscilla, De Vita, A., Melita, V., Romano, A., Ruggiero, Antonio, Attina, G., Lanza, Gaetano Antonio, Massetti, Massimo, Crea, Filippo, Lombardo, Antonella, Camilli M., Delogu A. B. (ORCID:0000-0002-2283-3180), Lamendola P., Ruggiero A. (ORCID:0000-0002-6052-3511), Lanza G. A. (ORCID:0000-0003-2187-6653), Massetti M. (ORCID:0000-0002-7100-8478), Crea F. (ORCID:0000-0001-9404-8846), Lombardo A. (ORCID:0000-0003-3162-1830), Camilli, Massimiliano, Birritella, L., Delogu, Angelica Bibiana, Lamendola, Priscilla, De Vita, A., Melita, V., Romano, A., Ruggiero, Antonio, Attina, G., Lanza, Gaetano Antonio, Massetti, Massimo, Crea, Filippo, Lombardo, Antonella, Camilli M., Delogu A. B. (ORCID:0000-0002-2283-3180), Lamendola P., Ruggiero A. (ORCID:0000-0002-6052-3511), Lanza G. A. (ORCID:0000-0003-2187-6653), Massetti M. (ORCID:0000-0002-7100-8478), Crea F. (ORCID:0000-0001-9404-8846), and Lombardo A. (ORCID:0000-0003-3162-1830)
- Abstract
Background: Cardiovascular (CV) diseases are a cause of increased long-term morbidity and mortality in childhood cancer survivors (CCSs) treated with anthracyclines. These drugs may affect not only the heart, but also the vascular system. Left ventricular-arterial coupling (LVAC) represents a reliable parameter of altered ventricular and vascular performance, with validated prognostic value and never investigated in this setting. Aim of this study was to assess, in CCSs and matched controls, LVAC changes, performed with different echocardiographic modalities, and their relationship with endothelial function. Methods: Twenty survivors treated with anthracyclines for childhood malignancies and a matched control group of 20 healthy subjects were enrolled. Arterial elastance (Ea), end-systolic elastance (Ees), Ea/Ees ratio, as well as three-dimensional (3D) LVAC (assessed by measurement of End Systolic Volume [ESV]/Stroke Volume [SV] ratio) were performed at rest. Endothelial function was evaluated by measurement of flow-mediated dilatation (FMD) of the brachial artery. Results: 3D SV and 3D ESV/SV ratio resulted respectively significantly lower and higher in CCSs than in controls, while Ea, Ees and Ea/Ees ratio were not different among groups. A positive correlation between 3D ESV/SV ratio and cumulative anthracycline doses, as well as with time after drug exposure were also found. Mean FMD was similar in CCSs and controls (8.45 ± 1.79 versus 9.41 ± 3.41, p = 0.34). Conclusions: In conclusion, conventional LVAC parameters were not shown to be significantly different between CCSs and controls; however, 3D SV and LVAC were significantly impaired in our population. In these patients, endothelial function was comparable to controls. Larger validation studies are therefore needed.
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- 2023
31. Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study
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Grandinetti, M, Locorotondo, Gabriella, Leccisotti, Lucia, Guarneri, A, Bruno, P, Marcolini, A, Farina, Piero, Gaudino, M F, Lanza, Gaetano Antonio, Crea, Filippo, Giordano, Alessandro, Massetti, Massimo, Locorotondo, G, Leccisotti, L (ORCID:0000-0002-6000-2898), Farina, P, Lanza, G A (ORCID:0000-0003-2187-6653), Crea, F (ORCID:0000-0001-9404-8846), Giordano, A (ORCID:0000-0002-6978-0880), Massetti, M (ORCID:0000-0002-7100-8478), Grandinetti, M, Locorotondo, Gabriella, Leccisotti, Lucia, Guarneri, A, Bruno, P, Marcolini, A, Farina, Piero, Gaudino, M F, Lanza, Gaetano Antonio, Crea, Filippo, Giordano, Alessandro, Massetti, Massimo, Locorotondo, G, Leccisotti, L (ORCID:0000-0002-6000-2898), Farina, P, Lanza, G A (ORCID:0000-0003-2187-6653), Crea, F (ORCID:0000-0001-9404-8846), Giordano, A (ORCID:0000-0002-6978-0880), and Massetti, M (ORCID:0000-0002-7100-8478)
- Abstract
PurposeTo prospectively compare changes in myocardial blood flow (MBF) and myocardial flow reserve (MFR) in multivessel coronary artery disease (MVCAD) patients undergoing incomplete revascularization (IR) versus complete revascularization (CR) by coronary artery bypass grafting (CABG).MethodsSeven male patients (age 68 +/- 9 years) with MVCAD underwent myocardial perfusion PET/CT with [13N]ammonia before and at least 4 months after CABG. Segmental resting and stress MBF as well as MFR were measured. Resting and during stress left ventricle ejection fraction (LVEF) were also calculated.ResultsThree patients (43%) underwent CR and four (57%) IR. Among 119 myocardial segments, 101 (85%) were revascularized, and 18 (15%) were not. After CABG, stress MBF (mL/min/gr) and MFR are significantly increased in all myocardial segments, with a greater increase in the revascularized segments (p = 0.013). In both groups, LVEF significantly decreased during stress at baseline PET (p = 0.04), but not after CABG.ConclusionStress MBF and MFR significantly improve after CABG in both revascularized and not directly revascularized myocardial segments. IR strategy may be considered in patients with high surgical risk for CR.
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- 2023
32. Dapagliflozin treatment is associated with a reduction of epicardial adipose tissue thickness and epicardial glucose uptake in human type 2 diabetes
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Cinti, Francesca, Leccisotti, Lucia, Sorice, G. P., Capece, Umberto, D'Amario, Domenico, Lorusso, Maria Luisa, Gugliandolo, Shawn, Morciano, C., Guarneri, A., Guzzardi, M. A., Mezza, Teresa, Capotosti, A., Indovina, Luca, Ferraro, Pietro Manuel, Iozzo, P., Crea, Filippo, Giordano, Alessandro, Giaccari, Andrea, Cinti F. (ORCID:0000-0001-5170-7055), Leccisotti L. (ORCID:0000-0002-6000-2898), Capece U., D'Amario D., Lorusso M., Gugliandolo S., Mezza T. (ORCID:0000-0001-5407-9576), Indovina L., Ferraro P. M. (ORCID:0000-0002-1379-022X), Crea F. (ORCID:0000-0001-9404-8846), Giordano A. (ORCID:0000-0002-6978-0880), Giaccari A. (ORCID:0000-0002-7462-7792), Cinti, Francesca, Leccisotti, Lucia, Sorice, G. P., Capece, Umberto, D'Amario, Domenico, Lorusso, Maria Luisa, Gugliandolo, Shawn, Morciano, C., Guarneri, A., Guzzardi, M. A., Mezza, Teresa, Capotosti, A., Indovina, Luca, Ferraro, Pietro Manuel, Iozzo, P., Crea, Filippo, Giordano, Alessandro, Giaccari, Andrea, Cinti F. (ORCID:0000-0001-5170-7055), Leccisotti L. (ORCID:0000-0002-6000-2898), Capece U., D'Amario D., Lorusso M., Gugliandolo S., Mezza T. (ORCID:0000-0001-5407-9576), Indovina L., Ferraro P. M. (ORCID:0000-0002-1379-022X), Crea F. (ORCID:0000-0001-9404-8846), Giordano A. (ORCID:0000-0002-6978-0880), and Giaccari A. (ORCID:0000-0002-7462-7792)
- Abstract
Objective: We recently demonstrated that treatment with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) leads to an increase in myocardial flow reserve in patients with type 2 diabetes (T2D) with stable coronary artery disease (CAD). The mechanism by which this occurs is, however, unclear. One of the risk factors for cardiovascular disease is inflammation of epicardial adipose tissue (EAT). Since the latter is often increased in type 2 diabetes patients, it could play a role in coronary microvascular dysfunction. It is also well known that SGLT-2i modify adipose tissue metabolism. We aimed to investigate the effects of the SGLT-2i dapagliflozin on metabolism and visceral and subcutaneous adipose tissue thickness in T2D patients with stable coronary artery disease and to verify whether these changes could explain observed changes in myocardial flow. Methods: We performed a single-center, prospective, randomized, double-blind, controlled clinical trial with 14 T2D patients randomized 1:1 to SGLT-2i dapagliflozin (10 mg daily) or placebo. The thickness of visceral (epicardial, mediastinal, perirenal) and subcutaneous adipose tissue and glucose uptake were assessed at baseline and 4 weeks after treatment initiation by 2-deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography/Computed Tomography during hyperinsulinemic euglycemic clamp. Results: The two groups were well-matched for baseline characteristics (age, diabetes duration, HbA1c, BMI, renal and heart function). Dapagliflozin treatment significantly reduced EAT thickness by 19% (p = 0.03). There was a significant 21.6% reduction in EAT glucose uptake during euglycemic hyperinsulinemic clamp in the dapagliflozin group compared with the placebo group (p = 0.014). There were no significant effects on adipose tissue thickness/metabolism in the other depots explored. Conclusions: SGLT-2 inhibition selectively reduces EAT thickness and EAT glucose uptake in T2D patients, suggesting a reduction of EAT in
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- 2023
33. N-Acetylcysteine and High-Dose Atorvastatin Reduce Oxidative Stress in an Ischemia-Reperfusion Model in the Rat Kidney
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Cusumano, G., Romagnoli, J., Liuzzo, G., Ciavarella, L.P., Severino, A., Copponi, G., Manchi, M., Giubilato, S., Zannoni, G.F., Stigliano, E., Caristo, M.E., Crea, F., and Citterio, F.
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- 2015
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34. Preparation and characterization of active Ni-supported catalyst for syngas production
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Candamano, S., Frontera, P., Macario, A., Crea, F., Nagy, J.B., and Antonucci, P.L.
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- 2015
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35. Modulating membrane shape and mechanics of minimal cells by light: area increase, softening and interleaflet coupling of membrane models doped with azobenzene-lipid photoswitches
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Aleksanyan, M., https://orcid.org/0000-0002-9817-6244, Grafmüller, A., https://orcid.org/0000-0002-1671-3158, Crea, F., Georgiev, V., Heberle, J., Dimova, R., and https://orcid.org/0000-0002-3872-8502
- Abstract
Light can effectively interrogate biological systems providing control over complex cellular processes. Particularly advantageous features of photo-induced processes are reversibility, physiological compatibility, and spatiotemporal precision. Understanding the underlying biophysics of light-triggered changes in bio-systems is crucial for cell viability and optimizing clinical applications of photo-induced processes in biotechnology, optogenetics and photopharmacology. Employing membranes doped with the photolipid azobenzene-phosphatidylcholine (azo-PC), we provide a holistic picture of light-triggered changes in membrane morphology, mechanics and dynamics. We combine microscopy of giant vesicles as minimal cell models, Langmuir monolayers, and molecular dynamics simulations. We employ giant vesicle elelctrodeformation as a facile and accurate approach to quantify the magnitude, reversibility and kinetics of light-induced area expansion/shrinkage as a result of azo-PC photoisomerization and content. Area increase as high as ~25% and a 10-fold decrease in the membrane bending rigidity is observed upon trans-to-cis azo-PC isomerization. These results are in excellent agreement with simulations data and monolayers. Simulations also show that trans-to-cis isomerization of azo-PC decreases the membrane leaflet coupling. We demonstrate that light can be used to finely manipulate the shape and mechanics of photolipid-doped minimal cell models and liposomal drug carriers, thus, presenting a promising therapeutic alternative for the repair of cellular disorders.Competing Interest StatementThe authors have declared no competing interest.
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- 2023
36. Different Phases of Disease in Lymphocytic Myocarditis: Clinical and Electrophysiological Characteristics
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Casella, M., Gasperetti, A., Compagnucci, P., Narducci, M. L., Pelargonio, G., Catto, V., Carbucicchio, C., Bencardino, G., Conte, E., Schicchi, N., Andreini, D., Pontone, G., Giovagnoni, A., Rizzo, S., Inzani, F., Basso, C., Natale, A., Tondo, C., Russo, A. D., and Crea, F.
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cardiac magnetic resonance imaging ,endomyocardial biopsy ,ventricular arrhythmias ,substrate characterization ,electroanatomical mapping ,myocarditis - Published
- 2023
37. Clinical outcomes of left ventricular unloading with microaxial flow pump Impella during venoarterial extracorporeal membrane oxygenation (VA-ECMO): a systematic review and updated meta-analysis
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Cappannoli, L, primary, Galli, M, additional, Zito, A, additional, Restivo, A, additional, Princi, G, additional, Leone, A M, additional, Vergallo, R, additional, Aurigemma, C, additional, Romagnoli, E, additional, Aspromonte, N, additional, Burzotta, F, additional, Trani, C, additional, Sanna, T, additional, Crea, F, additional, and D'Amario, D, additional
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- 2022
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38. Prognostic impact of plasma level of NT-pro BNP in patients with microvascular angina – a report from the international cohort study by COVADIS
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Shimokawa, H, primary, Suda, A, additional, Takahashi, J, additional, Ong, P, additional, Ang, D, additional, Berry, C, additional, Camici, P, additional, Crea, F, additional, Kaski, J, additional, Pepine, C, additional, Rimoldi, O, additional, Sechtem, U, additional, Yasuda, S, additional, Beltrame, J, additional, and Merz, C, additional
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- 2022
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39. The Impact of Living with INOCA
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Gulati, M, primary, Khan, N, additional, George, M, additional, Berry, C, additional, Chieffo, A, additional, Camici, P G, additional, Crea, F, additional, Kaski, J C, additional, Marzilli, M, additional, and Merz, C N B, additional
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- 2022
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40. Air pollution and coronary vasomotor disorders in patients with myocardial ischemia and non-obstructive coronary arteries
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Camilli, M, primary, Russo, M, additional, Rinaldi, R, additional, Iannaccone, G, additional, Del Buono, M G, additional, Lavecchia, G, additional, Crea, F, additional, and Montone, R A, additional
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- 2022
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41. Device-based remote monitoring strategies for guided management of patients with heart failure: a systematic review and meta-analysis
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Zito, A, primary, Princi, G, additional, Romiti, G F, additional, Basili, S, additional, Liuzzo, G, additional, Sanna, T, additional, Restivo, A, additional, Ciliberti, G, additional, Trani, C, additional, Burzotta, F, additional, Cesario, A, additional, Savarese, G, additional, Crea, F, additional, and D'Amario, D, additional
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- 2022
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42. Dapagliflozin improves Myocardial Flow Reserve in patients with Type 2 Diabetes: the DAPAHEART Trial
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D'Amario, D, primary, Leccisotti, L, additional, Cinti, F, additional, Sorice, G P, additional, Lorusso, M, additional, Guzzardi, M A, additional, Mezza, T, additional, Cocchi, C, additional, Capece, U, additional, Indovina, L, additional, Ferraro, P M, additional, Iozzo, P, additional, Giordano, A, additional, Giaccari, A, additional, and Crea, F, additional
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- 2022
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43. Revascularization strategies versus optimal medical therapy in chronic coronary syndrome: a systematic review and network meta-analysis
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Galli, M, primary, Benenati, S, additional, Zito, A, additional, Capodanno, D, additional, Biondi-Zoccai, G, additional, Ortega-Paz, L, additional, D'Amario, D, additional, Porto, I, additional, Burzotta, F, additional, Trani, C, additional, De Caterina, R, additional, Escaned, J, additional, Gaudino, M, additional, Angiolillo, D J, additional, and Crea, F, additional
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- 2022
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44. Morphological and clinical implications of the optical coherence tomography-derived lipid core burden index
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Biccire, F G, primary, Budassi, S, additional, Ozaki, Y, additional, Boi, A, additional, Romagnoli, E, additional, Di Pietro, R, additional, Debelak, C, additional, Sammartini, E, additional, Versaci, F, additional, Fabbiocchi, F, additional, Burzotta, F, additional, Crea, F, additional, Arbustini, E, additional, Alfonso, F, additional, and Prati, F, additional
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- 2022
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45. Left atrial strain analysis improves non-invasive estimation of left ventricular filling pressures in takotsubo syndrome
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Iannaccone, G, primary, Graziani, F, additional, Del Buono, M G, additional, Camilli, M, additional, Lillo, R, additional, Caffe', A, additional, La Vecchia, G, additional, Rinaldi, R, additional, Pedicino, D, additional, Sanna, T, additional, Trani, C, additional, Lombardo, A, additional, Lanza, G A, additional, Montone, R A, additional, and Crea, F, additional
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- 2022
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46. Atherosclerotic Coronary Plaque features in patients with Acute Coronary Syndrome and Chronic Obstructive Pulmonary Disease
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Russo, M, primary, Camilli, M, additional, La Vecchia, G, additional, Caffe', A, additional, Iannaccone, G, additional, Rinaldi, R, additional, Del Buono, M, additional, Trani, C, additional, Liuzzo, G, additional, Crea, F, additional, and Montone, R A, additional
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- 2022
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47. A methylation-dependent checkpoint by SETD7 promotes myocardial ischemic injury in mice and men
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Ambrosini, S, primary, Montecucco, F, additional, Koljin, D, additional, Akhmedov, A, additional, Pedicino, D, additional, Mohammed, S A, additional, Kiss, A, additional, Beltrami, A P, additional, Luscher, T F, additional, Crea, F, additional, Ruschitzka, F, additional, Hamdani, N, additional, Costantino, S, additional, and Paneni, F, additional
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- 2022
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48. Biomimetic complexes of divalent cobalt and zinc with N-heterocyclic dicarboxylic ligands
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Materazzi, S., Foti, C., Crea, F., Risoluti, R., and Finamore, J.
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- 2014
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49. Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice:: GLORIA-AF Registry
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Lip G. Y. H., Kotalczyk A., Teutsch C., Diener H. -C., Dubner S. J., Halperin J. L., Ma C. -S., Rothman K. J., Marler S., Gurusamy V. K., Huisman M. V., Abban D. W., Aziz E., Kalan M. B., Abdul N., Backes L. M., Bradman D., Abud A. M., Badings E., Brautigam D., Adams F., Bagni E., Breton N., Addala S., Baker S. H., Brouwers P. J. A. M., Adragao P., Bala R., Browne K., Ageno W., Baldi A., Cortada J. B., Aggarwal R., Bando S., Bruni A., Agosti S., Banerjee S., Brunschwig C., Agostoni P., Bank A., Buathier H., Aguilar F., Esquivias G. B., Buhl A., Linares J. A., Barr C., Bullinga J., Aguinaga L., Bartlett M., Cabrera J. W., Ahmed J., Basic Kes V., Caccavo A., Aiello A., Baula G., Cai S., Ainsworth P., Behrens S., Caine S., Aiub J. R., Bell A., Calo L., Al-Dallow R., Benedetti R., Calvi V., Alderson L., Mazuecos J. B., Sanchez M. C., Velasco J. A. A., Benhalima B., Candeias R., Alexopoulos D., Bergler-Klein J., Capuano V., Manterola F. A., Berneau J. -B., Capucci A., Aliyar P., Bernstein R. A., Caputo R., Alonso D., Berrospi P., Rizo T. C., da Costa F. A. A., Berti S., Cardona F., Amado J., Berz A., da Costa Darrieux F. C., Amara W., Best E., Vera Y. C. D., Amelot M., Bettencourt P., Carolei A., Amjadi N., Betzu R., Carreno S., Ammirati F., Bhagwat R., Carvalho P., Andrade M., Bhatta L., Cary S., Andrawis N., Biscione F., Casu G., Annoni G., Bisignani G., Cavallini C., Ansalone G., Black T., Cayla G., Ariani M. K., Bloch M. J., Celentano A., Arias J. C., Bloom S., Cha T. -J., Armero S., Blumberg E., Cha K. S., Arora C., Bo M., Chae J. K., Aslam M. S., Bohmer E., Chalamidas K., Asselman M., Bollmann A., Challappa K., Audouin P., Bongiorni M. G., Chand S. P., Augenbraun C., Boriani G., Chandrashekar H., Aydin S., Boswijk D. J., Chartier L., Bott J., Chatterjee K., Ayryanova I., Bottacchi E., Ayala C. A. C., Cheema A., Davis G., Evonich R., Davy J. -M., Evseeva O., Chen L., Dayer M., Ezhov A., Chen S. -A., De Biasio M., Fahmy R., Chen J. H., De Bonis S., Fang Q., Chiang F. -T., De Caterina R., Farsad R., Chiarella F., De Franceschi T., Fauchier L., Chih-Chan L., de Groot J. R., Favale S., Cho Y. K., De Horta J., Fayard M., Choi J. -I., De La Briolle A., Fedele J. L., Choi D. J., de la Pena Topete G., Fedele F., Chouinard G., de Paola A. A. V., Fedorishina O., Chow D. H. -F., de Souza W., Fera S. R., Chrysos D., de Veer A., Ferreira L. G. G., Chumakova G., De Wolf L., Ferreira J., Valenzuela E. J. J. R. C., Decoulx E., Ferri C., Nica N. C., Deepak S., Ferrier A., Cislowski D. J., Defaye P., Ferro H., Clay A., Munoz F. D. -C., Finsen A., Clifford P., Brkljacic D. D., First B., Cohen A., Deumite N. J., Fischer S., Cohen M., Di Legge S., Fonseca C., Cohen S., Diemberger I., Almeida L. F., Colivicchi F., Dietz D., Forman S., Collins R., Dionisio P., Frandsen B., Colonna P., Dong Q., French W., Compton S., dos Santos F. R., Friedman K., Connolly D., Dotcheva E., Friese A., Conti A., Doukky R., Fruntelata A. G., Buenostro G. C., D'Souza A., Fujii S., Coodley G., Dubrey S., Fumagalli S., Cooper M., Ducrocq X., Fundamenski M., Coronel J., Dupljakov D., Furukawa Y., Corso G., Duque M., Gabelmann M., Sales J. C., Dutta D., Gabra N., Cottin Y., Duvilla N., Gadsboll N., Covalesky J., Duygun A., Galinier M., Cracan A., Dziewas R., Gammelgaard A., Crea F., Eaton C. B., Ganeshkumar P., Crean P., Eaves W., Gans C., Crenshaw J., Ebels-Tuinbeek L. A., Quintana A. G., Cullen T., Ehrlich C., Gartenlaub O., Darius H., Eichinger-Hasenauer S., Gaspardone A., Dary P., Eisenberg S. J., Genz C., Dascotte O., Jabali A. E., Georger F., Dauber I., Shahawy M. E., Georges J. -L., Davalos V., Hernandes M. E., Georgeson S., Davies R., Izal A. E., Giedrimas E., Gierba M., Haruna T., Jarmukli N., Ortega I. G., Hayek E., Jeanfreau R. J., Gillespie E., Healey J., Jenkins R. D., Giniger A., Hearne S., Sanchez C. J., Giudici M. C., Heffernan M., Jimenez J., Gkotsis A., Heggelund G., Jobe R., Glotzer T. V., Heijmeriks J. A., Joen-Jakobsen T., Gmehling J., Hemels M., Jones N., Gniot J., Hendriks I., Jorge J. C. M., Goethals P., Henein S., Jouve B., Goldbarg S., Her S. -H., Jung B. C., Goldberg R., Hermany P., Jung K. T., Goldmann B., Del Rio J. E. H., Jung W., Golitsyn S., Higashino Y., Kachkovskiy M., Gomez S., Hill M., Kafkala K., Mesa J. G., Hisadome T., Kalinina L., Gonzalez V. B., Hishida E., Kallmunzer B., Hermosillo J. A. G., Hoffer E., Kamali F., Lopez V. M. G., Hoghton M., Kamo T., Gorka H., Hong K., Kampus P., Gornick C., Hong S., Kashou H., Gorog D., Horbach S., Kastrup A., Gottipaty V., Horiuchi M., Katsivas A., Goube P., Hou Y., Kaufman E., Goudevenos I., Hsing J., Kawai K., Graham B., Huang C. -H., Kawajiri K., Greer G. S., Huckins D., Kazmierski J. F., Gremmler U., Hughes K., Keeling P., Grena P. G., Huizinga A., Saraiva J. F. K., Grond M., Hulsman E. L., Ketova G., Gronda E., Hung K. -C., Khaira A. S., Gronefeld G., Hwang G. -S., Khripun A., Gu X., Ikpoh M., Kim D. -I., Torres I. G. T., Imberti D., Kim Y. H., Guardigli G., Ince H., Kim N. H., Guevara C., Indolfi C., Kim D. K., Guignier A., Inoue S., Kim J. S., Gulizia M., Irles D., Gumbley M., Iseki H., Kim K. S., Gunther A., Israel C. N., Kim J., Ha A., Iteld B., Kinova E., Hahalis G., Iyer V., Klein A., Hakas J., Jackson-Voyzey E., Kmetzo J. J., Hall C., Jaffrani N., Kneller G. L., Han B., Jager F., Knezevic A., Han S., James M., Koh S. M. 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A., Turner W., Savelieva I., Spinar J., Tveit A., Scala P. -J., Sprigings D., Tytus R., Schellinger P., Spyropoulos A. C., Valadao C., Scherr C., Stakos D., van Bergen P. F. M. M., Schmitz L., Steinwender C., van de Borne P., Schmitz K. -H., Stergiou G., van den Berg B. J., Schmitz B., Stiell I., van der Zwaan C., Schnabel T., Stoddard M., Van Eck M., Schnupp S., Stoikov A., Vanacker P., Schoeniger P., Streb W., Vasilev D., Schon N., Styliadis I., Vasilikos V., Schwimmbeck P., Su G., Vasilyev M., Seamark C., Su X., Veerareddy S., Searles G., Sudnik W., Mino M. V., Seidl K. -H., Sukles K., Venkataraman A., Seidman B., Sun X., Verdecchia P., Sek J., Swart H., Versaci F., Sekaran L., Szavits-Nossan J., Vester E. G., Serrati C., Taggeselle J., Vial H., Shah N., Takagi Y., Victory J., Shah V., Takhar A. P. S., Villamil A., Shah A., Tamm A., Vincent M., Shah S., Tanaka K., Vlastaris A., Sharma V. K., Tanawuttiwat T., Dahl J., Shaw L., Tang S., Vora K., Sheikh K. H., Tang A., Vranian R. B., Shimizu N., Tarsi G., Wakefield P., Shimomura H., Tassinari T., Wang N., Shin D. -G., Tayal A., Wang M., Shin E. -S., Tayebjee M., Wang X., Shite J., Berg J. M., Wang F., Sibilio G., Tesloianu D., Wang T., Silver F., The S. H. K., Warner A. L., Sime I., Thomas D., Watanabe K., Simmers T. A., Timsit S., Wei J., Singh N., Tobaru T., Weimar C., Siostrzonek P., Tomasik A. R., Weiner S., Smadja D., Torosoff M., Weinrich R., Smith D. W., Touze E., Wen M. -S., Snitman M., Trendafilova E., Wiemer M., Filho D. S., Tsai W. K., Wiggers P., Soda H., Tse H. F., Wilke A., Sofley C., Tsutsui H., Williams D., Williams M. L., Yan P. Y. B., Zhang P., Witzenbichler B., Yang T., Zhang J., Wong B., Yao J., Zhao S. P., Wong K. S. L., Yeh K. -H., Zhao Y., Wozakowska-Kaplon B., Yin W. H., Zhao Z., Wu S., Yotov Y., Zheng Y., Wu R. C., Zahn R., Zhou J., Wunderlich S., Zarich S., Zimmermann S., Wyatt N., Zenin S., Zini A., Wylie J., Zeuthen E. L., Zizzo S., Xu Y., Zhang H., Zong W., Xu X., Zhang D., Zukerman L. S., Yamanoue H., Zhang X., Yamashita T., Cardiology, ACS - Heart failure & arrhythmias, Lip G.Y.H., Kotalczyk A., Teutsch C., Diener H.-C., Dubner S.J., Halperin J.L., Ma C.-S., Rothman K.J., Marler S., Gurusamy V.K., Huisman M.V., Abban D.W., Aziz E., Kalan M.B., Abdul N., Backes L.M., Bradman D., Abud A.M., Badings E., Brautigam D., Adams F., Bagni E., Breton N., Addala S., Baker S.H., Brouwers P.J.A.M., Adragao P., Bala R., Browne K., Ageno W., Baldi A., Cortada J.B., Aggarwal R., Bando S., Bruni A., Agosti S., Banerjee S., Brunschwig C., Agostoni P., Bank A., Buathier H., Aguilar F., Esquivias G.B., Buhl A., Linares J.A., Barr C., Bullinga J., Aguinaga L., Bartlett M., Cabrera J.W., Ahmed J., Basic Kes V., Caccavo A., Aiello A., Baula G., Cai S., Ainsworth P., Behrens S., Caine S., Aiub J.R., Bell A., Calo L., Al-Dallow R., Benedetti R., Calvi V., Alderson L., Mazuecos J.B., Sanchez M.C., Velasco J.A.A., Benhalima B., Candeias R., Alexopoulos D., Bergler-Klein J., Capuano V., Manterola F.A., Berneau J.-B., Capucci A., Aliyar P., Bernstein R.A., Caputo R., Alonso D., Berrospi P., Rizo T.C., da Costa F.A.A., Berti S., Cardona F., Amado J., Berz A., da Costa Darrieux F.C., Amara W., Best E., Vera Y.C.D., Amelot M., Bettencourt P., Carolei A., Amjadi N., Betzu R., Carreno S., Ammirati F., Bhagwat R., Carvalho P., Andrade M., Bhatta L., Cary S., Andrawis N., Biscione F., Casu G., Annoni G., Bisignani G., Cavallini C., Ansalone G., Black T., Cayla G., Ariani M.K., Bloch M.J., Celentano A., Arias J.C., Bloom S., Cha T.-J., Armero S., Blumberg E., Cha K.S., Arora C., Bo M., Chae J.K., Aslam M.S., Bohmer E., Chalamidas K., Asselman M., Bollmann A., Challappa K., Audouin P., Bongiorni M.G., Chand S.P., Augenbraun C., Boriani G., Chandrashekar H., Aydin S., Boswijk D.J., Chartier L., Bott J., Chatterjee K., Ayryanova I., Bottacchi E., Ayala C.A.C., Cheema A., Davis G., Evonich R., Davy J.-M., Evseeva O., Chen L., Dayer M., Ezhov A., Chen S.-A., De Biasio M., Fahmy R., Chen J.H., De Bonis S., Fang Q., Chiang F.-T., De Caterina R., Farsad R., Chiarella F., De Franceschi T., Fauchier L., Chih-Chan L., de Groot J.R., Favale S., Cho Y.K., De Horta J., Fayard M., Choi J.-I., De La Briolle A., Fedele J.L., Choi D.J., de la Pena Topete G., Fedele F., Chouinard G., de Paola A.A.V., Fedorishina O., Chow D.H.-F., de Souza W., Fera S.R., Chrysos D., de Veer A., Ferreira L.G.G., Chumakova G., De Wolf L., Ferreira J., Valenzuela E.J.J.R.C., Decoulx E., Ferri C., Nica N.C., Deepak S., Ferrier A., Cislowski D.J., Defaye P., Ferro H., Clay A., Munoz F.D.-C., Finsen A., Clifford P., Brkljacic D.D., First B., Cohen A., Deumite N.J., Fischer S., Cohen M., Di Legge S., Fonseca C., Cohen S., Diemberger I., Almeida L.F., Colivicchi F., Dietz D., Forman S., Collins R., Dionisio P., Frandsen B., Colonna P., Dong Q., French W., Compton S., dos Santos F.R., Friedman K., Connolly D., Dotcheva E., Friese A., Conti A., Doukky R., Fruntelata A.G., Buenostro G.C., D'Souza A., Fujii S., Coodley G., Dubrey S., Fumagalli S., Cooper M., Ducrocq X., Fundamenski M., Coronel J., Dupljakov D., Furukawa Y., Corso G., Duque M., Gabelmann M., Sales J.C., Dutta D., Gabra N., Cottin Y., Duvilla N., Gadsboll N., Covalesky J., Duygun A., Galinier M., Cracan A., Dziewas R., Gammelgaard A., Crea F., Eaton C.B., Ganeshkumar P., Crean P., Eaves W., Gans C., Crenshaw J., Ebels-Tuinbeek L.A., Quintana A.G., Cullen T., Ehrlich C., Gartenlaub O., Darius H., Eichinger-Hasenauer S., Gaspardone A., Dary P., Eisenberg S.J., Genz C., Dascotte O., Jabali A.E., Georger F., Dauber I., Shahawy M.E., Georges J.-L., Davalos V., Hernandes M.E., Georgeson S., Davies R., Izal A.E., Giedrimas E., Gierba M., Haruna T., Jarmukli N., Ortega I.G., Hayek E., Jeanfreau R.J., Gillespie E., Healey J., Jenkins R.D., Giniger A., Hearne S., Sanchez C.J., Giudici M.C., Heffernan M., Jimenez J., Gkotsis A., Heggelund G., Jobe R., Glotzer T.V., Heijmeriks J.A., Joen-Jakobsen T., Gmehling J., Hemels M., Jones N., Gniot J., Hendriks I., Jorge J.C.M., Goethals P., Henein S., Jouve B., Goldbarg S., Her S.-H., Jung B.C., Goldberg R., Hermany P., Jung K.T., Goldmann B., Del Rio J.E.H., Jung W., Golitsyn S., Higashino Y., Kachkovskiy M., Gomez S., Hill M., Kafkala K., Mesa J.G., Hisadome T., Kalinina L., Gonzalez V.B., Hishida E., Kallmunzer B., Hermosillo J.A.G., Hoffer E., Kamali F., Lopez V.M.G., Hoghton M., Kamo T., Gorka H., Hong K., Kampus P., Gornick C., Hong S., Kashou H., Gorog D., Horbach S., Kastrup A., Gottipaty V., Horiuchi M., Katsivas A., Goube P., Hou Y., Kaufman E., Goudevenos I., Hsing J., Kawai K., Graham B., Huang C.-H., Kawajiri K., Greer G.S., Huckins D., Kazmierski J.F., Gremmler U., Hughes K., Keeling P., Grena P.G., Huizinga A., Saraiva J.F.K., Grond M., Hulsman E.L., Ketova G., Gronda E., Hung K.-C., Khaira A.S., Gronefeld G., Hwang G.-S., Khripun A., Gu X., Ikpoh M., Kim D.-I., Torres I.G.T., Imberti D., Kim Y.H., Guardigli G., Ince H., Kim N.H., Guevara C., Indolfi C., Kim D.K., Guignier A., Inoue S., Kim J.S., Gulizia M., Irles D., Gumbley M., Iseki H., Kim K.S., Gunther A., Israel C.N., Kim J., Ha A., Iteld B., Kinova E., Hahalis G., Iyer V., Klein A., Hakas J., Jackson-Voyzey E., Kmetzo J.J., Hall C., Jaffrani N., Kneller G.L., Han B., Jager F., Knezevic A., Han S., James M., Koh S.M.A., Hargrove J., Jang S.-W., Koide S., Hargroves D., Jaramillo N., Kollias A., Kooistra J.A., Li W., McClure J., Koons J., Li X., McCormack T., Koschutnik M., Lichy C., McGarity W., Kostis W.J., Lieber I., McIntyre H., Kovacic D., Rodriguez R.H.L., McLaurin B., Kowalczyk J., Lin H., Alvaro F., Palomino M., Koziolova N., Melandri F., Kraft P., Liu F., Meno H., Kragten J.A., Liu H., Menzies D., Krantz M., Esperon G.L., Mercader M., Krause L., Navarro N.L., Meyer C., Krenning B.J., Lo E., Meyer B.J., Krikke F., Lokshyn S., Miarka J., Kromhout Z., Lopez A., Mibach F., Krysiak W., Lopez-Sendon J.L., Michalski D., Kumar P., Filho A.M.L., Michel P., Kumler T., Lorraine R.S., Chreih R.M., Kuniss M., Luengas C.A., Luengas A., Mikdadi G., Kuo J.-Y., Luke R., Mikus M., Kuppers A., Luo M., Milicic D., Kurrelmeyer K., Lupovitch S., Militaru C., Kwak C.H., Lyrer P., Minaie S., Laboulle B., Ma C., Minescu B., Labovitz A., Ma G., Mintale I., Ter Lai W., Madariaga I., Mirault T., Lam A., Maeno K., Mirro M.J., Lam Y.Y., Magnin D., Mistry D., Lanas Zanetti F., Maid G., Miu N.V., Landau C., Mainigi S.K., Miyamoto N., Landini G., Makaritsis K., Moccetti T., Lanna Figueiredo E., Malhotra R., Mohammed A., Larsen T., Manning R., Nor A.M., Lavandier K., Manolis A., Mollerus M., LeBlanc J., Hurtado H.A.M., Molon G., Lee M.H., Mantas I., Mondillo S., Lee C.-H., Jattin F.M., Moniz P., Lehman J., Maqueda V., Mont L., Leitao A., Marchionni N., Montagud V., Lellouche N., Ortuno F.M., Montana O., Lelonek M., Santana A.M., Monti C., Lenarczyk R., Martinez J., Moretti L., Lenderink T., Maskova P., Mori K., Gonzalez S.L., Hernandez N.M., Moriarty A., Leong-Sit P., Matsuda K., Morka J., Leschke M., Maurer T., Moschini L., Ley N., Mauro C., Moschos N., Li Z., May E., Mugge A., Mayer N., Mulhearn T.J., Muresan C., Jose E.P., Precoma D.B., Muriago M., Padilla F.G.P., Prelle A., Musial W., Rios V.P., Prodafikas J., Musser C.W., Pajes G., Protasov K., Musumeci F., Pandey A.S., Pye M., Nageh T., Paparella G., Qiu Z., Nakagawa H., Paris F., Quedillac J.-M., Nakamura Y., Park H.W., Raev D., Nakayama T., Park J.S., Grado C.A.R., Nam G.-B., Parthenakis F., Rahimi S., Nanna M., Passamonti E., Raisaro A., Natarajan I., Patel R.J., Rama B., Nayak H.M., Patel J., Ramos R., Naydenov S., Patel M., Ranieri M., Nazlic J., Patrick J., Raposo N., Nechita A.C., Jimenez R.P., Rashba E., Nechvatal L., Paz A., Rauch-Kroehnert U., Negron S.A., Pengo V., Reddy R., Neiman J., Pentz W., Renda G., Neuenschwander F.C., Perez B., Reza S., Neves D., Rios A.M.P., Ria L., Neykova A., Perez-Cabezas A., Richter D., Miguel R.N., Perlman R., Rickli H., Nijmeh G., Persic V., Rieker W., Nizov A., Perticone F., Vera T.R., Campos R.N., Peters T.K., Ritt L.E., Nossan J., Petkar S., Roberts D., Novikova T., Pezo L.F., Briones I.R., Nowalany-Kozielska E., Pflucke C., Escudero A.E.R., Nsah E., Pham D.N., Pascual C.R., Fragoso J.C.N., Phillips R.T., Roman M., Nurgalieva S., Phlaum S., Romeo F., Nuyens D., Pieters D., Ronner E., Nyvad O., Pineau J., Roux J.-F., de Los Rios Ibarra M.O., Pinter A., Rozkova N., O'Donnell P., Pinto F., Rubacek M., O'Donnell M., Pisters R., Rubalcava F., Oh S., Pivac N., Russo A.M., Oh Y.S., Pocanic D., Rutgers M.P., Oh D., Podoleanu C., Rybak K., O'Hara G., Politano A., Said S., Oikonomou K., Poljakovic Z., Sakamoto T., Olivares C., Pollock S., Salacata A., Oliver R., Garcea J.P., Salem A., Ruiz R.O., Poppert H., Bodes R.S., Olympios C., Porcu M., Saltzman M.A., Omaszuk-Kazberuk A., Reino A.P., Salvioni A., Asensi J.O., Prasad N., Vallejo G.S., Fernandez M.S., Sokal A., Tu T.M., Saporito W.F., Yan Y.S.O., Tuininga Y., Sarikonda K., Sotolongo R., Turakhia M., Sasaoka T., de Souza O.F., Turk S., Sati H., Sparby J.A., Turner W., Savelieva I., Spinar J., Tveit A., Scala P.-J., Sprigings D., Tytus R., Schellinger P., Spyropoulos A.C., Valadao C., Scherr C., Stakos D., van Bergen P.F.M.M., Schmitz L., Steinwender C., van de Borne P., Schmitz K.-H., Stergiou G., van den Berg B.J., Schmitz B., Stiell I., van der Zwaan C., Schnabel T., Stoddard M., Van Eck M., Schnupp S., Stoikov A., Vanacker P., Schoeniger P., Streb W., Vasilev D., Schon N., Styliadis I., Vasilikos V., Schwimmbeck P., Su G., Vasilyev M., Seamark C., Su X., Veerareddy S., Searles G., Sudnik W., Mino M.V., Seidl K.-H., Sukles K., Venkataraman A., Seidman B., Sun X., Verdecchia P., Sek J., Swart H., Versaci F., Sekaran L., Szavits-Nossan J., Vester E.G., Serrati C., Taggeselle J., Vial H., Shah N., Takagi Y., Victory J., Shah V., Takhar A.P.S., Villamil A., Shah A., Tamm A., Vincent M., Shah S., Tanaka K., Vlastaris A., Sharma V.K., Tanawuttiwat T., Dahl J., Shaw L., Tang S., Vora K., Sheikh K.H., Tang A., Vranian R.B., Shimizu N., Tarsi G., Wakefield P., Shimomura H., Tassinari T., Wang N., Shin D.-G., Tayal A., Wang M., Shin E.-S., Tayebjee M., Wang X., Shite J., Berg J.M., Wang F., Sibilio G., Tesloianu D., Wang T., Silver F., The S.H.K., Warner A.L., Sime I., Thomas D., Watanabe K., Simmers T.A., Timsit S., Wei J., Singh N., Tobaru T., Weimar C., Siostrzonek P., Tomasik A.R., Weiner S., Smadja D., Torosoff M., Weinrich R., Smith D.W., Touze E., Wen M.-S., Snitman M., Trendafilova E., Wiemer M., Filho D.S., Tsai W.K., Wiggers P., Soda H., Tse H.F., Wilke A., Sofley C., Tsutsui H., Williams D., Williams M.L., Yan P.Y.B., Zhang P., Witzenbichler B., Yang T., Zhang J., Wong B., Yao J., Zhao S.P., Wong K.S.L., Yeh K.-H., Zhao Y., Wozakowska-Kaplon B., Yin W.H., Zhao Z., Wu S., Yotov Y., Zheng Y., Wu R.C., Zahn R., Zhou J., Wunderlich S., Zarich S., Zimmermann S., Wyatt N., Zenin S., Zini A., Wylie J., Zeuthen E.L., Zizzo S., Xu Y., Zhang H., Zong W., Xu X., Zhang D., Zukerman L.S., Yamanoue H., Zhang X., and Yamashita T.
- Subjects
Apixaban ,Atrial fibrillation ,Dabigatran ,Non-vitamin K antagonists ,Rivaroxaban ,Pyridones ,Medizin ,Myocardial Infarction ,Administration, Oral ,Anticoagulants ,Hemorrhage ,General Medicine ,Non-vitamin K antagonist ,Stroke ,Clinical Trials, Phase III as Topic ,Humans ,Prospective Studies ,Registries ,Cardiology and Cardiovascular Medicine - Abstract
Background and purpose Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013. Graphical abstract
- Published
- 2022
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50. Personalized clinical phenotyping through systems medicine and artificial intelligence
- Author
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Cesario, A, D'Oria, M, Bove, F, Privitera, G, Boskoski, I, Pedicino, D, Boldrini, L, Erra, C, Loreti, C, Liuzzo, G, Crea, F, Armuzzi, A, Gasbarrini, A, Calabresi, P, Padua, L, Costamagna, G, Antonelli, M, Valentini, V, Auffray, C, Scambia, G, Cesario A., D'oria M., Bove F., Privitera G., Boskoski I., Pedicino D., Boldrini L., Erra C., Loreti C., Liuzzo G., Crea F., Armuzzi A., Gasbarrini A., Calabresi P., Padua L., Costamagna G., Antonelli M., Valentini V., Auffray C., Scambia G., Cesario, A, D'Oria, M, Bove, F, Privitera, G, Boskoski, I, Pedicino, D, Boldrini, L, Erra, C, Loreti, C, Liuzzo, G, Crea, F, Armuzzi, A, Gasbarrini, A, Calabresi, P, Padua, L, Costamagna, G, Antonelli, M, Valentini, V, Auffray, C, Scambia, G, Cesario A., D'oria M., Bove F., Privitera G., Boskoski I., Pedicino D., Boldrini L., Erra C., Loreti C., Liuzzo G., Crea F., Armuzzi A., Gasbarrini A., Calabresi P., Padua L., Costamagna G., Antonelli M., Valentini V., Auffray C., and Scambia G.
- Abstract
Personalized Medicine (PM) has shifted the traditional top-down approach to medicine based on the identification of single etiological factors to explain diseases, which was not suitable for explaining complex conditions. The concept of PM assumes several interpretations in the literature, with particular regards to Genetic and Genomic Medicine. Despite the fact that some disease-modifying genes affect disease expression and progression, many complex conditions cannot be understood through only this lens, especially when other lifestyle factors can play a crucial role (such as the environment, emotions, nutrition, etc.). Personalizing clinical phenotyping becomes a challenge when different pathophysiological mechanisms underlie the same manifestation. Brain disorders, cardiovascular and gastroentero-logical diseases can be paradigmatic examples. Experiences on the field of Fondazione Policlinico Gemelli in Rome (a research hospital recognized by the Italian Ministry of Health as national leader in “Personalized Medicine” and “Innovative Biomedical Technologies”) could help understanding which techniques and tools are the most performing to develop potential clinical phenotypes person-alization. The connection between practical experiences and scientific literature highlights how this potential can be reached towards Systems Medicine using Artificial Intelligence tools.
- Published
- 2021
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