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Your search keyword '"CRABTREE, THOMAS S.J."' showing total 10 results
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10 results on '"CRABTREE, THOMAS S.J."'

1. Real-world outcomes of Omnipod DASH system use in people with type 1 diabetes: Evidence from the Association of British Clinical Diabetologists (ABCD) study

Author

Liarakos, Alexandros L., Hasan, Nebras, Crabtree, Thomas S.J., Leelarathna, Lalantha, Hammond, Peter, Hussain, Sufyan, Haq, Masud, Aslam, Aisha, Gatdula, Erneda, Gibb, Fraser W, Lumb, Alistair, Bull, Kirsty, Chinnasamy, Eswari, Carrieri, Giorgio, Williams, David M., Choudhary, Pratik, Ryder, Robert E.J., and Wilmot, Emma G.

Published
2024
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2. Hybrid Closed-Loop Therapy in Adults With Type 1 Diabetes and Above-Target HbA1c: A Real-world Observational Study.

Author

Crabtree, Thomas S.J., Griffin, Tomás P., Yap, Yew W., Narendran, Parth, Gallen, Geraldine, Furlong, Niall, Cranston, Iain, Chakera, Ali, Philbey, Chris, Karamat, Muhammad Ali, Saraf, Sanjay, Kamaruddin, Shafie, Gurnell, Eleanor, Chapman, Alyson, Hussain, Sufyan, Elliott, Jackie, Leelarathna, Lalantha, Ryder, Robert E.J., Hammond, Peter, and Lumb, Alistair

Subjects
*TYPE 1 diabetes, *SCIENTIFIC observation, *INSULIN pumps, *ADULTS, *INSULIN therapy
Abstract

OBJECTIVE: We explored longitudinal changes associated with switching to hybrid closed-loop (HCL) insulin delivery systems in adults with type 1 diabetes and elevated HbA1c levels despite the use of intermittently scanned continuous glucose monitoring (isCGM) and insulin pump therapy. RESEARCH DESIGN AND METHODS: We undertook a pragmatic, preplanned observational study of participants included in the National Health Service England closed-loop pilot. Adults using isCGM and insulin pump across 31 diabetes centers in England with an HbA1c ≥8.5% who were willing to commence HCL therapy were included. Outcomes included change in HbA1c, sensor glucometrics, diabetes distress score, Gold score (hypoglycemia awareness), acute event rates, and user opinion of HCL. RESULTS: In total, 570 HCL users were included (median age 40 [IQR 29–50] years, 67% female, and 85% White). Mean baseline HbA1c was 9.4 ± 0.9% (78.9 ± 9.1 mmol/mol) with a median follow-up of 5.1 (IQR 3.9–6.6) months. Of 520 users continuing HCL at follow-up, mean adjusted HbA1c reduced by 1.7% (95% CI 1.5, 1.8; P < 0.0001) (18.1 mmol/mol [95% CI 16.6, 19.6]; P < 0.0001). Time in range (70–180 mg/dL) increased from 34.2 to 61.9% (P < 0.001). Individuals with HbA1c of ≤58 mmol/mol rose from 0 to 39.4% (P < 0.0001), and those achieving ≥70% glucose time in range and <4% time below range increased from 0.8 to 28.2% (P < 0.0001). Almost all participants rated HCL therapy as having a positive impact on quality of life (94.7% [540 of 570]). CONCLUSIONS: Use of HCL is associated with improvements in HbA1c, time in range, hypoglycemia, and diabetes-related distress and quality of life in people with type 1 diabetes in the real world. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes

Author

Patel, Rachel, Crabtree, Thomas S.J., Taylor, Nicola, Langeland, Linn, Gazis, Anastasios (Tasso), Mendis, Buddhike, Wilmot, Emma G., and Idris, Iskandar

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract

Aims: The use of do-it-yourself artificial pancreas systems (DIYAPS) among people with type 1 diabetes is increasing. At present, it is unclear how DIYAPS compares with other technologies such as FreeStyle Libre (FSL) and continuous subcutaneous insulin infusion (CSII). The aim of this analysis is to compare safety, effectiveness and quality-of-life outcomes of DIYAPS use with the addition of FSL to CSII. Method: Data from two large UK hospitals were extracted from the Association of British Clinical Diabetologists (ABCD) DIYAPS and FSL audits. Outcomes included HbA1c, glucose TBR (time-below-range), TIR (time-in-range), Diabetes Distress Score (DDS), and Gold hypoglycaemia score. Any adverse events were noted. Changes at follow-up were assessed using paired t-tests and ANOVA in Stata; TIR/TBR at follow-up assessed using unpaired t-tests; chi-square tests assessed the change in frequency of health utilisation (e.g. hospital admissions). Results: DIYAPS (n=35) and FSL+CSII (n=149) users, with median follow-up duration of 1.4 (IQR 0.8–2.1) and 1.3 (IQR 0.7–1.8) years, respectively, were included. HbA1c with DIYAPS use changed by −10mmol/mol [0.9%] (p

Published
2022

4. 858-P: Predictors of HbA1c and Weight Response to Sodium–Glucose Cotransporter 2 Inhibitors (SGLT2i) in the Association of British Clinical Diabetologist (ABCD) UK Nationwide Audit

Author

CRABTREE, THOMAS S.J., primary, GALLAGHER, ALISON, additional, SIVAPPRIYAN, SIVA, additional, DHATARIYA, KETAN, additional, RAGHAVAN, RAJEEV P., additional, BICKERTON, ALEX, additional, ELLIOTT, JACKIE, additional, CULL, MELISSA L., additional, RAYMAN, GERRY, additional, GALLEN, IAN W., additional, IDRIS, ISKANDAR R., additional, and RYDER, ROBERT E., additional

Published
2022
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5. 756-P: The Effect of Semaglutide on Alanine Aminotransferase (ALT) Levels: Results from the Association of British Clinical Diabetologists (ABCD) Audit

Author

CRABTREE, THOMAS S.J., primary, SENNIK, DEVESH K., additional, BICKERTON, ALEX, additional, BARNES, DENNIS, additional, SIVAPPRIYAN, SIVA, additional, ADAMSON, KAREN, additional, PHILLIPS, SUZANNE M., additional, EVANS, ALISON, additional, LARSEN, NIELS, additional, PANESAR, AVINASH, additional, CULL, MELISSA L., additional, GALLEN, IAN W., additional, IDRIS, ISKANDAR R., additional, and RYDER, ROBERT E., additional

Published
2022
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6. 803-P: The Association between Empagliflozin and Changes in Alanine Aminotransferase Levels: Data from the Association of British Clinical Diabetologists (ABCD) Audit Programme

Author

CRABTREE, THOMAS S.J., primary, ELLIOTT, JACKIE, additional, BICKERTON, ALEX, additional, GALLEN, IAN W., additional, DHATARIYA, KETAN, additional, CULL, MELISSA L., additional, EVANS, ALISON, additional, PHILLIPS, SUZANNE M., additional, and RYDER, ROBERT E., additional

Published
2021
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8. 2224-PUB: The Effect of Diabetes Duration on Response to Empagliflozin: Data from the Association of British Clinical Diabetologists (ABCD) Audit Programme

Author

CRABTREE, THOMAS S.J., primary, ADAMSON, KAREN, additional, BICKERTON, ALEX, additional, PHILLIPS, SUZANNE M., additional, EVANS, ALISON, additional, ROBINSON, ANTHONY M., additional, ATKIN, MARC, additional, MORRIS, DAVID S., additional, WILLIAMS, DAVID M., additional, STEPHENS, JEFFREY W., additional, SENNIK, DEVESH K., additional, ROHILLA, ANURITA, additional, CULL, MELISSA L., additional, RAGHAVAN, RAJEEV P., additional, YADAGIRI, MAHENDER, additional, GALLEN, IAN W., additional, and RYDER, ROBERT E., additional

Published
2020
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9. 1104-P: Many Benefits of Empagliflozin Persist in Those with Reduced Renal Function: Updated Data from the Association of British Clinical Diabetologists (ABCD) Audit Programme

Author

CRABTREE, THOMAS S.J., primary, ADAMSON, KAREN, additional, BICKERTON, ALEX, additional, PHILLIPS, SUZANNE M., additional, EVANS, ALISON, additional, ROBINSON, ANTHONY M., additional, ATKIN, MARC, additional, MORRIS, DAVID S., additional, WILLIAMS, DAVID M., additional, STEPHENS, JEFFREY W., additional, SENNIK, DEVESH K., additional, ROHILLA, ANURITA, additional, CULL, MELISSA L., additional, RAGHAVAN, RAJEEV P., additional, YADAGIRI, MAHENDER, additional, GALLEN, IAN W., additional, and RYDER, ROBERT E., additional

Published
2020
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10. 1105-P: The Effect of Canagliflozin on Alanine Aminotransferase (ALT) Levels: Data from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit Programme

Author

CRABTREE, THOMAS S.J., primary, PHILLIPS, SUZANNE M., additional, EVANS, ALISON, additional, SENNIK, DEVESH K., additional, ROHILLA, ANURITA, additional, BICKERTON, ALEX, additional, DARZY, KEN H., additional, WINOCOUR, PETER, additional, CULL, MELISSA L., additional, STRZELECKA, ANNA, additional, RAGHAVAN, RAJEEV P., additional, GALLEN, IAN W., additional, YADAGIRI, MAHENDER, additional, and RYDER, ROBERT E., additional

Published
2020
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