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The effects of neutral gas heating along the direction of the gas flow inside the discharge channel of a parallel plate micro atmospheric pressure plasma jet, the COST-jet, on the spatio-temporal dynamics of energetic electrons are investigated by experiments and simulations. The plasma source is driven by a single frequency sinusoidal voltage waveform at 13.56 MHz in helium with an admixture (0.05–0.2%) of nitrogen. Optical emission spectroscopy measurements are applied to determine the spatio-temporally resolved electron impact excitation dynamics from the ground state into the He I (3s) 3 S 1 state and the rotational temperature of nitrogen molecules at different positions along the direction of the gas flow inside the 30 mm long discharge channel. The gas temperature, which is assumed to be equal to the N 2 rotational temperature, is found to increase along the discharge channel. This effect is attenuated as the nitrogen concentration is increased in the gas mixture, leading to an eventually constant temperature profile. The experimental data also reveal a plasma operating mode transition along the discharge channel from the Ω - to the Penning-mode and show good agreement with the results of 1d3v kinetic simulations, which spatially resolve the inter-electrode space and use the gas temperature as an input value. The simulations demonstrate that the increase of the gas temperature leads to the observed mode transition. The results suggest the possibility of using the nitrogen admixture and the feed gas temperature as additional control parameters, (i) to tailor the plasma operating mode along the direction of the gas flow so that the production of specific radicals is optimized; and (ii) to control the final gas temperature of the effluent. The latter could be particularly interesting for biological applications, where the upper gas temperature limit is dictated by the rather low thermal damage threshold of the treated material. [ABSTRACT FROM AUTHOR]

Radio-frequency-driven atmospheric pressure plasma jets (RF APPJs) play an essential role in many technological applications. This work studies the characteristics of these discharges in the so-called non-neutral regime where the conventional structure of a quasi-neutral bulk and an electron depleted sheath does not develop, and the electrons are instead organized in a drift-soliton-like structure that never reaches quasi-neutrality. A hybrid particle-in-cell/Monte Carlo collisions (PIC/MCC) simulation is set up, which combines a fully kinetic electron model via the PIC/MCC algorithm with a drift-diffusion model for the ions. In addition, an analytical model for the electron dynamics is formulated. The formation of the soliton-like structure and the connection between the soliton and the electron dynamics are investigated. The location of the electron group follows a drift equation, while the spatial shape can be described by Poissonâ€"Boltzmann equilibrium in a co-moving frame. A stability analysis is conducted using the Lyapunov method and a linear stability analysis. A comparison of the numerical simulation with the analytical models yields a good agreement. [ABSTRACT FROM AUTHOR]

This study investigated the use of glutathione as a marker to establish a correlation between plasma parameters and the resultant liquid chemistry from two distinct sources to predefined biological outcomes. Two different plasma sources were operated at parameters that resulted in similar biological responses: cell viability, mitochondrial activity, and the cell surface display of calreticulin. Specific glutathione modifications appeared to be associated with biological responses elicited by plasma. These modifications were more pronounced with increased treatment time for the European Cooperation in Science and Technology Reference Microplasma Jet (COST-Jet) and increased frequency for the dielectric barrier discharge and were correlated with more potent biological responses. No correlations were found when cells or glutathione were exposed to exogenously added long-lived species alone. This implied that short-lived species and other plasma components were required for the induction of cellular responses, as well as glutathione modifications. These results showed that comparisons of medical plasma sources could not rely on measurements of long-lived chemical species; rather, modifications of biomolecules (such as glutathione) might be better predictors of cellular responses to plasma exposure. [ABSTRACT FROM AUTHOR]

This study investigated the use of glutathione as a marker to establish a correlation between plasma parameters and the resultant liquid chemistry from two distinct sources to predefined biological outcomes. Two different plasma sources were operated at parameters that resulted in similar biological responses: cell viability, mitochondrial activity, and the cell surface display of calreticulin. Specific glutathione modifications appeared to be associated with biological responses elicited by plasma. These modifications were more pronounced with increased treatment time for the European Cooperation in Science and Technology Reference Microplasma Jet (COST-Jet) and increased frequency for the dielectric barrier discharge and were correlated with more potent biological responses. No correlations were found when cells or glutathione were exposed to exogenously added long-lived species alone. This implied that short-lived species and other plasma components were required for the induction of cellular responses, as well as glutathione modifications. These results showed that comparisons of medical plasma sources could not rely on measurements of long-lived chemical species; rather, modifications of biomolecules (such as glutathione) might be better predictors of cellular responses to plasma exposure.