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2. Risk assessment tools for bleeding in patients with unprovoked venous thromboembolism: an analysis of the PLATO-VTE study

Author

Guman, Noori A.M., Becking, Anne-Marie L., Weijers, Suzanne S., Kraaijpoel, Noémie, Mulder, Frits I., Carrier, Marc, Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Johannes M.M.B., Cosmi, Benilde, Peters, Mike J.L., Wolde, Marije ten, Delluc, Aurélien, Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Gerdes, Victor E.A., Büller, Harry R., van Es, Nick, and Kamphuisen, Pieter W.

Published
2024
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4. Statins under-treatment and mortality in patients with atrial fibrillation. Insights from the nationwide START registry

Author

Testa, Sophie, Cosmi, Benilde, Guazzaloca, Giuliana, Migliaccio, Ludovica, Poli, Daniela, Marcucci, Rossella, Maggini, Niccolò, Pengo, Vittorio, Falanga, Anna, Lerede, Teresa, Ruocco, Lucia, Martini, Giuliana, Pedrini, Simona, Bertola, Federica, Masciocco, Lucilla, Saracino, Pasquale, Benvenuto, Angelo, Vasselli, Claudio, Violi, Francesco, Pignatelli, Pasquale, Pastori, Daniele, Grandone, Elvira, Colaizzo, Donatella, Marzolo, Marco, Pinelli, Mauro, Mastroiacovo, Daniela, Ageno, Walter, Colombo, Giovanna, Bucherini, Eugenio, Serra, Domizio, Toma, Andrea, Barbera, Pietro, Paparo, Carmelo, Insana, Antonio, Rupoli, Serena, Malcangi, Giuseppe, Zighetti, Maddalena Loredana, Mangione, Catello, Lione, Domenico, Casasco, Paola, Nante, Giovanni, Tosetto, Alberto, Oriana, Vincenzo, Liberato, Nicola Lucio, Menichelli, Danilo, Antonucci, Emilia, and Palareti, Gualtiero

Published
2023
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5. Venous thromboembolism secondary to hospitalization for COVID-19: patient management and long-term outcomes

Author

Ageno, Walter, Girardi, Laura, Sterpone, Paola, Cosmi, Benilde, Bucherini, Eugenio, Chistolini, Antonio, Serrao, Alessandra, Di Nisio, Marcello, Potere, Nicola, Porreca, Ettore, Fregoni, Vittorio, Grandone, Elvira, Colaizzo, Donatella, Insana, Antonio, Lerede, Teresa, Falanga, Anna, Martinelli, Ida, Bucciarelli, Paolo, Abbattista, Maria, Martini, Giuliana, Masciocco, Lucilla, Mastroiacovo, Daniela, Pancani, Roberta, Carrozzi, Laura, Paparo, Carmelo, Pedrini, Simona, Pieralli, Filippo, Milia, Alessandro, Pignatelli, Pasquale, Menichelli, Danilo, Pizzini, Attilia Maria, Silingardi, Mauro, Podda, GianMarco, Birocchi, Simone, Poli, Daniela, Crudele, Felice, Lotti, Elena, Marcucci, Rossella, Preti, Paola Stefania, Sarti, Luca, Trovati, Alice, Caronna, Antonella, Famiglietti, Elena, Lami, Francesca, Nicolini, Alberto, Scaglioni, Federica, Testa, Sophie, Paoletti, Oriana, Tosetto, Alberto, Toma, Andrea, Villalta, Sabina, Visonà, Adriana, Zalunardo, Beniamino, Panzavolta, Chiara, Antonucci, Emilia, Podda, Gian Marco, and Palareti, Gualtiero

Published
2023
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6. Platelet RNA sequencing for cancer screening in patients with unprovoked venous thromboembolism: a prospective cohort study

Author

Mulder, Frits I., Kraaijpoel, Noémie, Carrier, Marc, Guman, Noori A., Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Hans-Martin B., Cosmi, Benilde, Wolde, Marije ten, In ‘t Veld, Sjors G.J. G., Post, Edward, Ramaker, Jip, Zwaan, Kenn, Peters, Mike, Delluc, Aurélien, Kamphuisen, Pieter W., Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Büller, Harry R., Wurdinger, Thomas, Best, Myron G., and van Es, Nick

Published
2023
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7. 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE

Author

Loualidi, Ab, Colak, Abdurrahim, Bezuidenhout, Abraham, Abdool-Carrim, Abu, Azeddine, Addala, Beyers, Adriaan, Dees, Adriaan, Mohamed, Ahmed, Aksoy, Ahmet, Abiko, Akihiko, Watanabe, Akinori, Krichell, Alan, Fernandez, Alberto Alfredo, Tosetto, Alberto, Khotuntsov, Alexey, Oropallo, Alisha, Slocombe, Alison, Kelly, Allan, Clark, Amanda, Gad, Amr, Arouni, Amy, Schmidt, Andor, Berni, Andrea, Kleiban, Andres Javier, Machowski, Andrew, Kazakov, Andrey, Galvez, Angel, Lockman, Ann, Falanga, Anna, Chauhan, Anoop, Riera-Mestre, Antoni, Mazzone, Antonino, D'Angelo, Armando, Herdy, Artur, Kato, Atsushi, Salem, Ayman Abd Elhamid Ebrahim Mahmoud, Husin, Azlan, Erdelyi, Barbara, Jacobson, Barry, Amann-Vesti, Beatrice, Battaloglu, Bektas, Wilson, Benedicte, Cosmi, Benilde, Francois, Bergmann Jean, Toufek, Berremeli, Hunt, Beverley, Natha, Bhavesh, Mustafa, Bisher, Kho, Bonnie Chi Shan, Carine, Boulon, Zidel, Brian, Dominique, Brisot, Christophe, Brousse, Trimarco, Bruno, Luo, Canhua, Cuneo, Carlos Alberto, Diaz, Carlos Jerjes Sanchez, Schwencke, Carsten, Cader, Cas, Yavuz, Celal, Zaidman, Cesar Javier, Lunn, Charles, Wu, Chau-Chung, Toh, Cheng Hock, Chiang, Chern-En, Elisa, Chevrier, Hsia, Chien-Hsun, Huang, Chien-Lung, Kwok, Chi-Hang Kevin, Wu, Chih-Cheng, Huang, Chi-Hung, Ward, Chris, Opitz, Christian, Jeanneret-Gris, Christina, Ha, Chung Yin, Huang, Chun-Yao, Bidi, Claude Luyeye, Smith, Clifford, Brauer, Cornelia, Lodigiani, Corrado, Francis, Couturaud, Wu, Cynthia, Staub, Daniel, Theodoro, Daniel, Poli, Daniela, Acevedo, David - Riesco, Adler, David, Jimenez, David, Keeling, David, Scott, David, Imberti, Davide, Creagh, Desmond, Helene, Desmurs-Clavel, Hagemann, Dirk, Le Roux, Dirk, Skowasch, Dirk, Belenky, Dmitry, Dorokhov, Dmitry, Petrov, Dmitry, Zateyshchikov, Dmitry, Prisco, Domenico, Møller, Dorthe, Kucera, Dusan, Esheiba, Ehab M., Panchenko, Elizaveta, Dominique, Elkouri, Dogan, Emre, Kubat, Emre, Diaz, Enrique Diaz, Tse, Eric Wai Choi, Yeo, Erik, Hashas, Erman, Grochenig, Ernst, Tiraferri, Eros, Blessing, Erwin, Michèle, Escande Orthlieb, Usandizaga, Esther, Porreca, Ettore, Ferroni, Fabian, Nicolas, Falvo, Ayala-Paredes, Félix, Koura, Firas, Henry, Fitjerald, Cosmi, Franco, Erdkamp, Frans, Kamalov, Gadel, Dalmau, Garcia-Bragado, Damien, Garrigues, Klein, Garry, Shah, Gaurand, Hollanders, Geert, Merli, Geno, Plassmann, Georg, Platt, George, Poirier, Germain, Sokurenko, German, Haddad, Ghassan, Ali, Gholam, Agnelli, Giancarlo, Gan, Gin Gin, Kaye-Eddie, Grace, Le Gal, Gregoire, Allen, Gregory, Esperón, Guillermo Antonio Llamas, Jean-Paul, Guillot, Gerofke, Hagen, Elali, Hallah, Burianova, Hana, Ohler, Hans-Juergen, Wang, Haofu, Darius, Harald, Gogia, Harinder S., Striekwold, Harry, Gibbs, Harry, Hasanoglu, Hatice, Turker, Hatice, Franow, Hendrik, Bounameaux, Henri, De Raedt, Herbert, Schroe, Herman, ElDin, Hesham Salah, Zidan, Hesham, Nakamura, Hiroaki, Kim, Ho Young, Lawall, Holger, Zhu, Hong, Tian, Hongyan, Yhim, Ho-Young, ten Cate, Hugo, Hwang, Hun Gyu, Shim, Hyeok, Kim, Igor, Libov, Igor, Sonkin, Igor, Suchkov, Igor, Song, Ik-Chan, Kiris, Ilker, Staroverov, Ilya, Looi, Irene, De La Azuela Tenorio, Isabel M., Savas, Ismail, Gordeev, Ivan, Podpera, Ivo, Lee, Jae Hoon, Sathar, Jameela, Welker, James, Beyer-Westendorf, Jan, Kvasnicka, Jan, Vanwelden, Jan, Kim, JangYong, Svobodova, Jaromira, Gujral, Jaspal, Marino, Javier, Galvar, Javier Tristan, Kassis, Jeannine, Kuo, Jen-Yuan, Shih, Jhih-Yuan, Kwon, JiHyun, Joh, Jin Hyun, Park, Jin Hyun, Kim, Jin Seok, Yang, Jinghua, Krupicka, Jiri, Lastuvka, Jiri, Pumprla, Jiri, Vesely, Jiri, Souto, Joan Carlos, Correa, João Antônio, Duchateau, Johan, Fletcher, John Perry, del Toro, Jorge, Paez, Jorge Guillermo Chavez, Nielsen, Jørn, Filho, Jose Dalmo Araujo, Saraiva, Jose, Peromingo, Jose Antonio Diaz, Lara, Jose Gomez, Fedele, Jose Luis, Surinach, Jose Maria, Chacko, Joseph, Muntaner, Juan Antonio, Benitez, Juan Carlos Álvarez, Abril, Juan Moreno Hoyos, Humphrey, Julian, Bono, Julio, Kanda, Junji, Boondumrongsagoon, Juree, Yiu, Kai Hang, Chansung, Kanchana, Boomars, Karin, Burbury, Kate, Kondo, Katsuhiro, Karaarslan, Kemal, Takeuchi, Kensuke, Kroeger, Knut, Zrazhevskiy, Konstantin, Svatopluk, Koscál, Shyu, Kou-Gi, Vandenbosch, Kristel, Chang, Kuan-Cheng, Chiu, Kuan-Ming, Jean-Manuel, Kubina, Wern, Kwan Jing, Ueng, Kwo-Chang, Norasetthada, Lalita, Binet, Laure, Chew, Lee Ping, Zhang, Lei, Cristina, Leone Maria, Tick, Lidwine, Schiavi, Lilia Beatriz, Wong, Lily Lee Lee, Borges, Lohana, Botha, Louis, Capiau, Luc, Timmermans, Luc, López, Luciano Eduardo, Ria, Luigi, Blasco, Luis Manuel Hernandez, Guzman, Luis Alberto, Cervera, Luis Flota, Isabelle, Mahe, Bosch, Manuel Monreal, de los Rios Ibarra, Manuel, Fernandez, Manuel Núñez, Carrier, Marc, Barrionuevo, Marcelo Raul, Gamba, Marco Antonio Alcocer, Cattaneo, Marco, Moia, Marco, Bowers, Margaret, Chetanachan, Mariam, Berli, Mario Alberto, Fixley, Mark, Faghih, Markus, Stuecker, Markus, Schul, Marlin, Banyai, Martin, Koretzky, Martin, Myriam, Martin, Gaffney, Mary Elizabeth, Hirano, Masao, Kanemoto, Masashi, Nakamura, Mashio, Tahar, Mersel, Emmanuel, Messas, Kovacs, Michael, Leahy, Michael, Levy, Michael, Munch, Michael, Olsen, Michael, De Pauw, Michel, Gustin, Michel, Van Betsbrugge, Michiel, Boyarkin, Mikhail, Homza, Miroslav, Koto, Modise, Abdool-Gaffar, Mohamed, Nagib, Mohamed Ayman Fakhry, El-Dessoki, Mohamed, Khan, Mohamed, Mohamed, Monniaty, Kim, Moo Hyun, Lee, Moon-Hee, Soliman, Mosaad, Ahmed, Mostafa Shawky, el Bary, Mostafa Soliman Abd, Moustafa, Moustafa A., Hameed, Muhammad, Kanko, Muhip, Majumder, Mujibur, Zubareva, Nadezhda, Mumoli, Nicola, Abdullah, Nik Azim Nik, Makruasi, Nisa, Paruk, Nishen, Kanitsap, Nonglak, Duda, Norberto, Nordin, Nordiana, Nyvad, Ole, Barbarash, Olga, Gurbuz, Orcun, Vilamajo, Oscar Gomez, Flores, Oscar Nandayapa, Gur, Ozcan, Oto, Oztekin, Marchena, Pablo Javier, Angchaisuksiri, Pantep, Carroll, Patrick, Lang, Pavel, MacCallum, Peter, von Bilderling, Peter Baron, Blombery, Peter, Verhamme, Peter, Jansky, Petr, Bernadette, Peuch, De Vleeschauwer, Philippe, Hainaut, Philippe, Ferrini, Piera Maria, Iamsai, Piriyaporn, Christian, Ponchaux, Viboonjuntra, Pongtep, Rojnuckarin, Ponlapat, Ho, Prahlad, Mutirangura, Pramook, Wells, Rachel, Martinez, Rafael, Miranda, Raimundo Tirado, Kroening, Ralf, Ratsela, Rapule, Reyes, Raquel Lopez, de Leon, Raul Franco Diaz, Wong, Raymond Siu Ming, Alikhan, Raz, Jerwan-Keim, Reinhold, Otero, Remedios, Murena-Schmidt, Renate, Canevascini, Reto, Ferkl, Richard, White, Richard, Van Herreweghe, Rika, Santoro, Rita, Klamroth, Robert, Mendes, Robert, Prosecky, Robert, Cappelli, Roberto, Spacek, Rudolf, Singh, Rupesh, Griffin, Sam, Na, Sang Hoon, Chunilal, Sanjeev, Middeldorp, Saskia, Nakazawa, Satoshi, Schellong, Sebastian, Toh, See Guan, Christophe, Seinturier, Isbir, Selim, Raymundo, Selma, Ting, Seng Kiat, Motte, Serge, Aktogu, Serir Ozkan, Donders, Servaas, Cha, Seung Ick, Nam, Seung-Hyun, Marie-Antoinette, Sevestre-Pietri, Maasdorp, Shaun, Sun, Shenghua, Wang, Shenming, Essameldin, Sherif Mohamed, Sholkamy, Sherif Mohamed, Kuki, Shintaro, Goto, Shinya, Yoshida, Shuichi, Matsuoka, Shunzo, McRae, Simon, Watt, Simon, Patanasing, Siriwimon, Jean-Léopold, Siwe-Nana, Wongkhantee, Somchai, Bang, Soo-Mee, Testa, Sophie, Zemek, Stanislav, Behrens, Steffen, Dominique, Stephan, Mellor, Stuart, Singh, Suaran Singh Gurcharan, Datta, Sudip, Chayangsu, Sunee, Solymoss, Susan, Everington, Tamara, Abdel-Azim, Tarek Ahmed Adel, Suwanban, Tawatchai, Adademir, Taylan, Hart, Terence, Béatrice, Terriat, Luvhengo, Thifhelimbilu, Horacek, Thomas, Zeller, Thomas, Boussy, Tim, Reynolds, Tim, Biss, Tina, Chao, Ting-Hsing, Casabella, Tomas Smith, Onodera, Tomoya, Numbenjapon, Tontanai, Gerdes, Victor, Cech, Vladimir, Krasavin, Vladimir, Tolstikhin, Vladimir, Bax, W.A., Malek, Wagih Fawzy Abdel, Ho, Wai Khoon, Ageno, Walter, Pharr, Walter, Jiang, Weihong, Lin, Wei-Hsiang, Zhang, Weihua, Tseng, Wei-Kung, Lai, Wen-Ter, De Backer, Wilfried, Haverkamp, Wilhelm, Yoshida, Winston, Korte, Wolfgang, Choi, Won Il, Kim, Yang-Ki, Tanabe, Yasuhiro, Ohnuma, Yasushi, Mun, Yeung-Chul, Balthazar, Yohan, Park, Yong, Shibata, Yoshisato, Burov, Yuriy, Subbotin, Yuriy, Coufal, Zdenek, Yang, Zhenwen, Jing, Zhicheng, Yang, Zhongqi, Turpie, Alexander G.G., Farjat, Alfredo E., Haas, Sylvia, Weitz, Jeffrey I., Goldhaber, Samuel Z., Kayani, Gloria, Lopes, Renato D., Tse, Eric, Muntaner, Juan, Prandoni, Paolo, Maheshwari, Uma, and Kakkar, Ajay K.

Published
2023
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10. D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study

Author

Palareti, Gualtiero, Poli, Daniela, Ageno, Walter, Legnani, Cristina, Antonucci, Emilia, Bucherini, Eugenio, Testa, Sophie, Paoletti, Oriana, Chistolini, Antonio, Serrao, Alessandra, Martinelli, Ida, Bucciarelli, Paolo, Falanga, Anna, Tosetto, Alberto, Sarti, Luca, Mastroiacovo, Daniela, Cosmi, Benilde, Visonà, Adriana, Santoro, Rita Carlotta, Zanatta, Nello, Grandone, Elvira, Bertù, Lorenza, Pengo, Vittorio, Caiano, Lucia, and Prandoni, Paolo

Published
2022
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11. Long‐term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta‐analysis

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S., Kearon, Clive, Weitz, Jeffrey I., Büller, Harry R., Raskob, Gary E., Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A., Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert‐Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A., Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W.A., Gebel, Martin, Grosso, Michael A., Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Published
2021
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13. Enhancing stroke risk prediction in patients with transient ischemic attack: insights from a prospective cohort study implementing fast-track care.

Author

Barone, Valentina, Foschi, Matteo, Pavolucci, Lucia, Rondelli, Francesca, Rinaldi, Rita, Nicodemo, Marianna, D’Angelo, Roberto, Favaretto, Elisabetta, Brusi, Carlotta, Cosmi, Benilde, Esposti, Daniela Degli, D’Addato, Sergio, Bacchelli, Stefano, Giostra, Fabrizio, Pomata, Daniela Paola, Spinardi, Luca, Faccioli, Luca, Faggioli, Gianluca, Donti, Andrea, and Borghi, Claudio

Subjects
TRANSIENT ischemic attack, STROKE, STROKE units, LONGITUDINAL method, POISSON regression, COHORT analysis
Abstract

Background and aims: Fast-track care have been proved to reduce the shortterm risk of stroke after transient ischemic attack (TIA). We aimed to investigate stroke risk and to characterize short- and long-term stroke predictors in a large cohort of TIA patients undergoing fast-track management. Methods: Prospective study, enrolling consecutive TIA patients admitted to a Northern Italy emergency department from August 2010 to December 2017. All patients underwent fast-track care within 24  h of admission. The primary outcome was defined as the first stroke recurrence at 90  days, 12 and 60  months after TIA. Stroke incidence with 95% confidence interval (CI) at each timepoint was calculated using Poisson regression. Predictors of stroke recurrence were evaluated with Cox regression analysis. The number needed to treat (NNT) of fast-track care in preventing 90-day stroke recurrence in respect to the estimates based on baseline ABCD2 score was also calculated. Results: We enrolled 1,035 patients (54.2% males). Stroke incidence was low throughout the follow-up with rates of 2.2% [95% CI 1.4–3.3%] at 90 days, 2.9% [95% CI 1.9–4.2%] at 12 months and 7.1% [95% CI 5.4–9.0%] at 60 months. Multiple TIA, speech disturbances and presence of ischemic lesion at neuroimaging predicted stroke recurrence at each timepoint. Male sex and increasing age predicted 90-day and 60-month stroke risk, respectively. Hypertension was associated with higher 12-month and 60-month stroke risk. No specific TIA etiology predicted higher stroke risk throughout the followup. The NNT for fast-track care in preventing 90-day stroke was 14.5 [95% CI 11.3–20.4] in the overall cohort and 6.8 [95% CI 4.6–13.5] in patients with baseline ABCD2 of 6 to 7. Conclusion: Our findings support the effectiveness of fast-track care in preventing both short- and long-term stroke recurrence after TIA. Particular effort should be made to identify and monitor patients with baseline predictors of higher stroke risk, which may vary according to follow-up duration. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Sex Differences in Clinical Presentation of Lower Extremity Deep Vein Thrombosis.

Author

Cosmi, Benilde, Borgese, Laura, Legnani, Cristina, Sartori, Michelangelo, and Palareti, Gualtiero

Subjects
*LEG, *OUTPATIENT services in hospitals, *VENOUS thrombosis, *SEX distribution, *FIBRIN fibrinogen degradation products, *RETROSPECTIVE studies, *HOSPITAL emergency services, *DESCRIPTIVE statistics, *COMPARATIVE studies, *ALGORITHMS, *SYMPTOMS
Abstract

Background: Differences between men and women in the clinical features and extent of lower limb deep vein thrombosis (DVT) may influence DVT diagnostic algorithms involving pretest clinical probability (PTP) assessment, D-dimer, and compression ultrasonography (CUS). Aims: To assess differences in DVT clinical presentation between men and women and their effect on PTP and D-dimer. Methods: We conducted a retrospective study in outpatients referred for suspected DVT of the lower limbs to our vascular emergency department from January 2005 to December 2019. Patients underwent PTP assessment with the Wells score, D-dimer testing, and CUS. Results: More women were referred for suspected DVT than men (M/F: 1,785/2,821; F: 61.4%; p < 0.0001). Women were older than men (median age: 71 vs. 67 years; p = 0.0001), DVT was diagnosed in 436 patients (9.4%) but in more men than women (M: 210 [11.8%] vs. F: 226 [8%]; p = 0.0002), with more proximal DVT in men than women (M: 131 7.3% vs. F: 124 [4.4%]; p = 0.00021). PTP was more likely in men (355 [19.9%]) than women (455 [16.2%]) (p = 0.0011); more men had swelling in the entire limb, increased calf circumference by >3 cm compared with the contralateral limb, and pitting edema, than women. D-dimer levels (available in 65% of patients) were more frequently positive in women with DVT than in men (94.6% vs. 85.7%; p = 0.016). However, a positive D-dimer and/or likely PTP was similarly frequent in men (92%) and women (96%) with DVT. Conclusions: More women than men are referred for suspected DVT, and men have a higher prevalence of proximal DVT. However, current algorithms for DVT diagnosis perform similarly in men and in women. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Gynecological Cancer and Venous Thromboembolism: A Narrative Review to Increase Awareness and Improve Risk Assessment and Prevention.

Author

Falanga, Anna, Lorusso, Domenica, Colombo, Nicoletta, Cormio, Gennaro, Cosmi, Benilde, Scandurra, Giuseppa, Zanagnolo, Vanna, and Marietta, Marco

Subjects
THROMBOEMBOLISM prevention, RISK assessment, PATIENT education, VEINS, CANCER patients, FEMALE reproductive organ tumors, HEALTH promotion, PREVENTIVE health services
Abstract

Simple Summary: Preventing venous thromboembolic complications in patient with gynecological cancers is a relevant issue and an unmet clinical need. Using a thorough literature search, we found that this problem is underestimated and preventative antithrombotic measures are underused. In addition, there are no specific validated risk assessment tools in this setting to help in clinical practice the identification of patients who are at highest thrombotic risk, who may most benefit from pharmacological anticoagulant prophylaxis, and avoid the anticoagulation-associated bleeding risk in those who are at low risk. We suggest that more research be done in this field to improve these patiens' care. The prevention and appropriate management of venous thromboembolism in cancer patients is of paramount importance. However, the literature data report an underestimation of this major problem in patients with gynecological cancers, with an inconsistent venous thromboembolism risk assessment and prophylaxis in this patient setting. This narrative review provides a comprehensive overview of the available evidence regarding the management of venous thromboembolism in cancer patients, focusing on the specific context of gynecological tumors, exploring the literature discussing risk factors, risk assessment, and pharmacological prophylaxis. We found that the current understanding and management of venous thromboembolism in gynecological malignancy is largely based on studies on solid cancers in general. Hence, further, larger, and well-designed research in this area is needed. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Inappropriate Underdosing of Direct Oral Anticoagulants in Atrial Fibrillation Patients: Results from the START2-AF Registry.

Author

Poli, Daniela, Antonucci, Emilia, Ageno, Walter, Berteotti, Martina, Falanga, Anna, Pengo, Vittorio, Chiarugi, Paolo, Cosmi, Benilde, Paparo, Carmelo, Chistolini, Antonio, Insana, Antonio, Lione, Domenico, Malcangi, Giuseppe, Martini, Giuliana, Masciocco, Lucilla, Pedrini, Simona, Bucherini, Eugenio, Pastori, Daniele, Pignatelli, Pasquale, and Toma, Andrea

Subjects
ATRIAL fibrillation, ORAL medication, INAPPROPRIATE prescribing (Medicine), STROKE, KIDNEY failure
Abstract

Background: Direct oral anticoagulants (DOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (NVAF) patients. We aimed to describe the prevalence of inappropriate DOACs dose prescription in the START2-AF Registry, the outcomes according to the appropriateness of the dosage, and the factors associated with inappropriate dose prescription. Methods: Patients' demographics and clinical data were prospectively collected as electronic files in an anonymous form on the website of the START2-Registry; DOACs dosage was determined to be appropriate when prescribed according to the European Heart Rhythm Association Guidelines. Results: We included 5943 NVAF patients on DOACs; 2572 (46.3%) were female patients. The standard dose (SD) was prescribed to 56.9% of patients and the low dose (LD) was prescribed to 43.1% of patients; 38.9% of all NVAF patients received an inappropriate LD DOAC and 0.3% received inappropriate SD. Patients treated with LD DOAC had a significantly higher rate of all bleedings (RR 1.5; 95% CI 1.2–2.0), major bleedings (RR 1.8; 95% CI 1.3–1.7), and mortality (RR 2.8; 95% CI 1.9–4.1) with respect to patients treated with SD DOAC. No difference was found among patients treated with appropriate and inappropriate LD regarding bleeding, thrombotic, and mortality rates. Age, body weight <60 kg, and renal failure were significantly associated with inappropriate LD DOAC prescription. Conclusions: Inappropriate LD DOACs in NVAF patients is not associated with a reduction in bleeding risk, nor with an increased thrombotic risk. Instead, it is associated with higher mortality rate, suggesting that, in clinical practice, underdosing is preferred for patients at particularly high risk for adverse events. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: A communication from the Platelet Physiology SSC

Author

Gresele, Paolo, Orsini, Sara, Noris, Patrizia, Falcinelli, Emanuela, Alessi, Marie Christine, Bury, Loredana, Borhany, Munira, Santoro, Cristina, Glembotsky, Ana C., Cid, Ana Rosa, Tosetto, Alberto, De Candia, Erica, Fontana, Pierre, Guglielmini, Giuseppe, Pecci, Alessandro, Heller, Paula G., Rodorigo, Giuseppina, Lammle, Bernhard, Trinchero, Alice, Paolo, Radossi, Ferrari, Silvia, Rancitelli, Davide, Stolinski, Amy, Arulselvan, Abinaya, Lassandro, Giuseppe, Luceros, Analia Sanchez, Jandrot‐Perrus, Martine, Kunishima, Shinji, Rivera Pozo, José, Lordkipanidzé, Marie, Melazzini, Federica, Falaise, Céline, Casonato, Alessandra, Podda, Gianmarco, Kannan, Meganathan, Jurk, Kerstin, Sevivas, Teresa, Castaman, Giancarlo, Grandone, Elvira, Fiore, Mathieu, Zuniga, Pamela, Henskens, Yvonne, Miyazaki, Koji, Dupuis, Arnaud, Hayward, Catherine, Zaninetti, Carlo, Abid, Madiha, Ferrara, Grazia, Mazzucconi, Maria Gabriella, Tagariello, Giuseppe, James, Paula, Fabris, Fabrizio, Russo, Alexandra, Bermejo, Nuria, Napolitano, Mariasanta, Curnow, Jennifer, Vasiliki, Gkalea, Zieger, Barbara, Fedor, Marian, Chitlur, Meera, Lambert, Michele, Barcella, Luca, Cosmi, Benilde, Giordano, Paola, Porri, Claudia, Eker, Ibrahim, Morel‐Kopp, Marie‐Christine, Deckmyn, Hans, Frelinger, Andrew L., III, Harrison, Paul, Mezzano, Diego, and Mumford, Andrew D.

Published
2020
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19. Statins under-treatment and mortality in patients with atrial fibrillation. Insights from the nationwide START registry

Author

Menichelli, Danilo, primary, Antonucci, Emilia, additional, Pignatelli, Pasquale, additional, Violi, Francesco, additional, Palareti, Gualtiero, additional, Pastori, Daniele, additional, Testa, Sophie, additional, Cosmi, Benilde, additional, Guazzaloca, Giuliana, additional, Migliaccio, Ludovica, additional, Poli, Daniela, additional, Marcucci, Rossella, additional, Maggini, Niccolò, additional, Pengo, Vittorio, additional, Falanga, Anna, additional, Lerede, Teresa, additional, Ruocco, Lucia, additional, Martini, Giuliana, additional, Pedrini, Simona, additional, Bertola, Federica, additional, Masciocco, Lucilla, additional, Saracino, Pasquale, additional, Benvenuto, Angelo, additional, Vasselli, Claudio, additional, Grandone, Elvira, additional, Colaizzo, Donatella, additional, Marzolo, Marco, additional, Pinelli, Mauro, additional, Mastroiacovo, Daniela, additional, Ageno, Walter, additional, Colombo, Giovanna, additional, Bucherini, Eugenio, additional, Serra, Domizio, additional, Toma, Andrea, additional, Barbera, Pietro, additional, Paparo, Carmelo, additional, Insana, Antonio, additional, Rupoli, Serena, additional, Malcangi, Giuseppe, additional, Zighetti, Maddalena Loredana, additional, Mangione, Catello, additional, Lione, Domenico, additional, Casasco, Paola, additional, Nante, Giovanni, additional, Tosetto, Alberto, additional, Oriana, Vincenzo, additional, and Liberato, Nicola Lucio, additional

Published
2023
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20. Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD‐VTE patients

Author

Haas, Sylvia, Ageno, Walter, Weitz, Jeffrey I., Goldhaber, Samuel Z., Turpie, Alexander G.G., Goto, Shinya, Angchaisuksiri, Pantep, Dalsgaard Nielsen, Joern, Kayani, Gloria, Zaghdoun, Audrey, Farjat, Alfredo E., Schellong, Sebastian, Bounameaux, Henri, Mantovani, Lorenzo G., Prandoni, Paolo, Kakkar, Ajay K., Loualidi, Ab, Colak, Abdurrahim, Bezuidenhout, Abraham, Abdool‐Carrim, Abu, Azeddine, Addala, Beyers, Adriaan, Dees, Adriaan, Mohamed, Ahmed, Aksoy, Ahmet, Abiko, Akihiko, Watanabe, Akinori, Krichell, Alan, Fernandez, Alberto Alfredo, Tosetto, Alberto, Khotuntsov, Alexey, Oropallo, Alisha, Slocombe, Alison, Kelly, Allan, Clark, Amanda, Gad, Amr, Arouni, Amy, Schmidt, Andor, Berni, Andrea, Kleiban, Andres Javier, Machowski, Andrew, Kazakov, Andrey, Galvez, Angel, Lockman, Ann, Falanga, Anna, Chauhan, Anoop, Riera‐Mestre, Antoni, Mazzone, Antonino, D'Angelo, Armando, Herdy, Artur, Kato, Atsushi, Ebrahim, Ayman Abd Elhamid, Salem, Mahmoud, Husin, Azlan, Erdelyi, Barbara, Jacobson, Barry, Amann‐Vesti, Beatrice, Battaloglu, Bektas, Wilson, Benedicte, Cosmi, Benilde, Francois, Bergmann Jean, Toufek, Berremeli, Hunt, Beverley, Natha, Bhavesh, Mustafa, Bisher, Kho, Bonnie Chi Shan, Carine, Boulon, Zidel, Brian, Dominique, Brisot, Christophe, Brousse, Trimarco, Bruno, Luo, Canhua, Alberto Cuneo, Carlos, Sanchez Diaz, Carlos Jerjes, Schwencke, Carsten, Cader, Cas, Yavuz, Celal, Javier Zaidman, Cesar, Lunn, Charles, Wu, Chau‐Chung, Toh, Cheng Hock, Chiang, Chern‐En, Elisa, Chevrier, Hsia, Chien‐Hsun, Huang, Chien‐Lung, Kwok, Chi‐Hang Kevin, Wu, Chih‐Cheng, Huang, Chi‐Hung, Ward, Chris, Opitz, Christian, Jeanneret‐Gris, Christina, Ha, Chung Yin, Huang, Chun‐Yao, Bidi, Claude Luyeye, Smith, Clifford, Brauer, Cornelia, Lodigiani, Corrado, Francis, Couturaud, Wu, Cynthia, Staub, Daniel, Theodoro, Daniel, Poli, Daniela, Acevedo, Riesco, Adler, David, Jimenez, David, Keeling, David, Scott, David, Imberti, Davide, Creagh, Desmond, Helene, Desmurs‐Clavel, Hagemann, Dirk, Le Roux, Dirk, Skowasch, Dirk, Belenky, Dmitry, Dorokhov, Dmitry, Petrov, Dmitry, Zateyshchikov, Dmitry, Prisco, Domenico, Møller, Dorthe, Kucera, Dusan, Esheiba, Ehab M., Panchenko, Elizaveta, Dominique, Elkouri, Dogan, Emre, Kubat, Emre, Diaz Diaz, Enrique, Tse, Eric Wai Choi, Yeo, Erik, Hashas, Erman, Grochenig, Ernst, Tiraferri, Eros, Blessing, Erwin, Michèle, Escande Orthlieb, Usandizaga, Esther, Porreca, Ettore, Ferroni, Fabian, Nicolas, Falvo, Ayala‐Paredes, Félix, Koura, Firas, Henry, Fitjerald, Cosmi, Franco, Erdkamp, Frans, Kamalov, Gadel, Dalmau, Garcia‐Bragado, Damien, Garrigues, Klein, Garry, Shah, Gaurand, Hollanders, Geert, Merli, Geno, Plassmann, Georg, Platt, George, Poirier, Germain, Sokurenko, German, Haddad, Ghassan, Ali, Gholam, Agnelli, Giancarlo, Gan, Gin Gin, Kaye‐Eddie, Grace, Le Gal, Gregoire, Allen, Gregory, Llamas Esperón, Guillermo Antonio, Jean‐Paul, Guillot, Gerofke, Hagen, Elali, Hallah, Burianova, Hana, Ohler, Hans‐Juergen, Wang, Haofu, Darius, Harald, Gogia, Harinder S., Striekwold, Harry, Gibbs, Harry, Hasanoglu, Hatice, Turker, Hatice, Franow, Hendrik, De Raedt, Herbert, Schroe, Herman, ElDin, Hesham Salah, Zidan, Hesham, Nakamura, Hiroaki, Kim, Ho Young, Lawall, Holger, Zhu, Hong, Tian, Hongyan, Yhim, Ho‐Young, ten Cate, Hugo, Hwang, Hun Gyu, Shim, Hyeok, Kim, Igor, Libov, Igor, Sonkin, Igor, Suchkov, Igor, Song, Ik‐Chan, Kiris, Ilker, Staroverov, Ilya, Looi, Irene, De La Azuela Tenorio, Isabel M, Savas, Ismail, Gordeev, Ivan, Podpera, Ivo, Lee, Jae Hoon, Sathar, Jameela, Welker, James, Beyer‐Westendorf, Jan, Kvasnicka, Jan, Vanwelden, Jan, Kim, JangYong, Svobodova, Jaromira, Gujral, Jaspal, Marino, Javier, Galvar, Javier Tristan, Kassis, Jeannine, Kuo, Jen‐Yuan, Shih, Jhih‐Yuan, Kwon, JiHyun, Joh, Jin Hyun, Park, Jin Hyun, Kim, Jin Seok, Yang, Jinghua, Krupicka, Jiri, Lastuvka, Jiri, Pumprla, Jiri, Vesely, Jiri, Carlos Souto, Joan, Antônio Correa, João, Duchateau, Johan, Fletcher, John Perry, del Toro, Jorge, Chavez Paez, Jorge Guillermo, Araujo Filho, Jose Dalmo, Saraiva, Jose, Diaz Peromingo, Jose Antonio, Gomez Lara, Jose, Luis Fedele, Jose, Maria Surinach, Jose, Chacko, Joseph, Antonio Muntaner, Juan, Álvarez Benitez, Juan Carlos, Hoyos Abril, Juan Moreno, Humphrey, Julian, Bono, Julio, Kanda, Junji, Boondumrongsagoon, Juree, Yiu, Kai Hang, Chansung, Kanchana, Boomars, Karin, Burbury, Kate, Kondo, Katsuhiro, Karaarslan, Kemal, Takeuchi, Kensuke, Kroeger, Knut, Zrazhevskiy, Konstantin, Svatopluk, Koscál, Shyu, Kou‐Gi, Vandenbosch, Kristel, Chang, Kuan‐Cheng, Chiu, Kuan‐Ming, Jean‐Manuel, Kubina, Wern, Kwan Jing, Ueng, Kwo‐Chang, Norasetthada, Lalita, Binet, Laure, Chew, Lee Ping, Zhang, Lei, Cristina, Leone Maria, Tick, Lidwine, Beatriz Schiavi, Lilia, Wong, Lily Lee Lee, Borges, Lohana, Botha, Louis, Capiau, Luc, Timmermans, Luc, Eduardo López, Luciano, Ria, Luigi, Hernandez Blasco, Luis Manuel, Guzman, Luis Alberto, Flota Cervera, Luis, Isabelle, Mahe, Monreal Bosch, Manuel, de los Rios Ibarra, Manuel, Núñez Fernandez, Manuel, Carrier, Marc, Raul Barrionuevo, Marcelo, Alcocer Gamba, Marco Antonio, Cattaneo, Marco, Moia, Marco, Bowers, Margaret, Chetanachan, Mariam, Berli, Mario Alberto, Fixley, Mark, Faghih, Markus, Stuecker, Markus, Schul, Marlin, Banyai, Martin, Koretzky, Martin, Myriam, Martin, Gaffney, Mary Elizabeth, Hirano, Masao, Kanemoto, Masashi, Nakamura, Mashio, Tahar, Mersel, Emmanuel, Messas, Kovacs, Michael, Leahy, Michael, Levy, Michael, Munch, Michael, Olsen, Michael, De Pauw, Michel, Gustin, Michel, Van Betsbrugge, Michiel, Boyarkin, Mikhail, Homza, Miroslav, Koto, Modise, Abdool‐Gaffar, Mohamed, Nagib, Mohamed Ayman Fakhry, El‐Dessoki, Mohamed, Khan, Mohamed, Mohamed, Monniaty, Kim, Moo Hyun, Lee, Moon‐Hee, Soliman, Mosaad, Ahmed, Mostafa Shawky, el Bary, Mostafa Soliman Abd, Moustafa, Moustafa A., Hameed, Muhammad, Kanko, Muhip, Majumder, Mujibur, Zubareva, Nadezhda, Mumoli, Nicola, Abdullah, Nik Azim Nik, Makruasi, Nisa, Paruk, Nishen, Kanitsap, Nonglak, Duda, Norberto, Nordin, Nordiana, Nyvad, Ole, Barbarash, Olga, Gurbuz, Orcun, Vilamajo, Oscar Gomez, Nandayapa Flores, Oscar, Gur, Ozcan, Oto, Oztekin, Javier Marchena, Pablo, Carroll, Patrick, Lang, Pavel, MacCallum, Peter, von Bilderling, Peter Baron, Blombery, Peter, Verhamme, Peter, Jansky, Petr, Bernadette, Peuch, De Vleeschauwer, Philippe, Hainaut, Philippe, Ferrini, Piera Maria, Iamsai, Piriyaporn, Christian, Ponchaux, Viboonjuntra, Pongtep, Rojnuckarin, Ponlapat, Ho, Prahlad, Mutirangura, Pramook, Wells, Rachel, Martinez, Rafael, Miranda, Raimundo Tirado, Kroening, Ralf, Ratsela, Rapule, Reyes, Raquel Lopez, Diaz de Leon, Raul Franco, Wong, Raymond Siu Ming, Alikhan, Raz, Jerwan‐Keim, Reinhold, Otero, Remedios, Murena‐Schmidt, Renate, Canevascini, Reto, Ferkl, Richard, White, Richard, Van Herreweghe, Rika, Santoro, Rita, Klamroth, Robert, Mendes, Robert, Prosecky, Robert, Cappelli, Roberto, Spacek, Rudolf, Singh, Rupesh, Griffin, Sam, Na, Sang Hoon, Chunilal, Sanjeev, Middeldorp, Saskia, Nakazawa, Satoshi, Toh, See Guan, Christophe, Seinturier, Isbir, Selim, Raymundo, Selma, Ting, Seng Kiat, Motte, Serge, Aktogu, Serir Ozkan, Donders, Servaas, Cha, Seung Ick, Nam, Seung‐Hyun, Marie‐Antoinette, Sevestre‐Pietri, Maasdorp, Shaun, Sun, Shenghua, Wang, Shenming, Essameldin, Sherif Mohamed, Sholkamy, Sherif Mohamed, Kuki, Shintaro, Yoshida, Shuichi, Matsuoka, Shunzo, McRae, Simon, Watt, Simon, Patanasing, Siriwimon, Jean‐Léopold, Siwe‐Nana, Wongkhantee, Somchai, Bang, Soo‐Mee, Testa, Sophie, Zemek, Stanislav, Behrens, Steffen, Dominique, Stephan, Mellor, Stuart, Singh, Suaran Singh Gurcharan, Datta, Sudip, Chayangsu, Sunee, Solymoss, Susan, Everington, Tamara, Abdel‐Azim, Tarek Ahmed Adel, Suwanban, Tawatchai, Adademir, Taylan, Hart, Terence, Béatrice, Terriat, Luvhengo, Thifhelimbilu, Horacek, Thomas, Zeller, Thomas, Boussy, Tim, Reynolds, Tim, Biss, Tina, Chao, Ting‐Hsing, Casabella, Tomas Smith, Onodera, Tomoya, Numbenjapon, Tontanai, Gerdes, Victor, Cech, Vladimir, Krasavin, Vladimir, Tolstikhin, Vladimir, Bax, W.A., Malek, Wagih Fawzy Abdel, Ho, Wai Khoon, Pharr, Walter, Jiang, Weihong, Lin, Wei‐Hsiang, Zhang, Weihua, Tseng, Wei‐Kung, Lai, Wen‐Ter, De Backer, Wilfried, Haverkamp, Wilhelm, Yoshida, Winston, Korte, Wolfgang, Choi, Won II, Kim, Yang‐Ki, Tanabe, Yasuhiro, Ohnuma, Yasushi, Mun, Yeung‐Chul, Balthazar, Yohan, Park, Yong, Shibata, Yoshisato, Burov, Yuriy, Subbotin, Yuriy, Coufal, Zdenek, Yang, Zhenwen, Jing, Zhicheng, and Yang, Zhongqi

Published
2019
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26. Capsular Warning Syndrome: Features, Risk Profile, and Prognosis in a Large Prospective TIA Cohort

Author

Foschi, Matteo, Pavolucci, Lucia, Rondelli, Francesca, Barone, Valentina, Rinaldi, Rita, Spinardi, Luca, Favaretto, Elisabetta, Rucci, Paola, Giostra, Fabrizio, Cosmi, Benilde, Borghi, Claudio, Cortelli, Pietro, and Guarino, Maria

Subjects
Stroke, Treatment, Neurology, Capsular warning syndrome, TIA, Neurology (clinical), Prognosis, Cardiology and Cardiovascular Medicine
Abstract

Introduction: Features and prognosis of capsular warning syndrome (CWS) have been poorly investigated prospectively. Aims: The study aimed to characterize CWS clinical features, risk profile, short- and long-term prognosis, among a large TIA cohort. Methods: Prospective cohort study of consecutive TIAs was conducted from August 1, 2010, to December 31, 2017. Demographic and clinical characteristics, risk profile, primary (stroke and composite outcome) and secondary (TIA recurrence, cerebral hemorrhage, new onset atrial fibrillation) outcomes were compared between CWS, lacunar (L), and nonlacunar (NL) TIAs. Results: 1,035 patients (33 CWS, 189 L-TIAs, 813 NL-TIAs) were enrolled. Newly diagnosed (ND) hypertension, hypercholesterolemia, cigarette smoking, and leukoaraiosis were independent risk factors of CWS (p < 0.05). CWS showed the highest stroke (30.3% vs. 0.5% and 1.5% for L-TIAs and NL-TIAs, respectively) and composite outcome risk at follow-up (p < 0.001), but better 3-month post-stroke prognosis (mRS 0–2 90.0% vs. 36.8%; p = 0.002). CWS-related stroke mostly occurred p = 0.010). Intravenous thrombolysis (IVT) showed similar 3-month efficacy and safety in strokes after TIAs groups (median mRS 0, IQR 0–1; p = 0.323). Conclusions: CWS is associated with higher stroke risk and better functional prognosis than L- and NL-TIAs. CWS risk profile is consistent with severe small vessel disease, and ND hypertension could represent a major risk factor. DAPT and IVT seem effective and safe in preventing and treating stroke following CWS.

Published
2022

28. 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE

Author

Turpie, Alexander G.G., primary, Farjat, Alfredo E., additional, Haas, Sylvia, additional, Ageno, Walter, additional, Weitz, Jeffrey I., additional, Goldhaber, Samuel Z., additional, Goto, Shinya, additional, Angchaisuksiri, Pantep, additional, Kayani, Gloria, additional, Lopes, Renato D., additional, Chiang, Chern-En, additional, Gibbs, Harry, additional, Tse, Eric, additional, Verhamme, Peter, additional, ten Cate, Hugo, additional, Muntaner, Juan, additional, Schellong, Sebastian, additional, Bounameaux, Henri, additional, Prandoni, Paolo, additional, Maheshwari, Uma, additional, Kakkar, Ajay K., additional, Loualidi, Ab, additional, Colak, Abdurrahim, additional, Bezuidenhout, Abraham, additional, Abdool-Carrim, Abu, additional, Azeddine, Addala, additional, Beyers, Adriaan, additional, Dees, Adriaan, additional, Mohamed, Ahmed, additional, Aksoy, Ahmet, additional, Abiko, Akihiko, additional, Watanabe, Akinori, additional, Krichell, Alan, additional, Fernandez, Alberto Alfredo, additional, Tosetto, Alberto, additional, Khotuntsov, Alexey, additional, Oropallo, Alisha, additional, Slocombe, Alison, additional, Kelly, Allan, additional, Clark, Amanda, additional, Gad, Amr, additional, Arouni, Amy, additional, Schmidt, Andor, additional, Berni, Andrea, additional, Kleiban, Andres Javier, additional, Machowski, Andrew, additional, Kazakov, Andrey, additional, Galvez, Angel, additional, Lockman, Ann, additional, Falanga, Anna, additional, Chauhan, Anoop, additional, Riera-Mestre, Antoni, additional, Mazzone, Antonino, additional, D'Angelo, Armando, additional, Herdy, Artur, additional, Kato, Atsushi, additional, Salem, Ayman Abd Elhamid Ebrahim Mahmoud, additional, Husin, Azlan, additional, Erdelyi, Barbara, additional, Jacobson, Barry, additional, Amann-Vesti, Beatrice, additional, Battaloglu, Bektas, additional, Wilson, Benedicte, additional, Cosmi, Benilde, additional, Francois, Bergmann Jean, additional, Toufek, Berremeli, additional, Hunt, Beverley, additional, Natha, Bhavesh, additional, Mustafa, Bisher, additional, Kho, Bonnie Chi Shan, additional, Carine, Boulon, additional, Zidel, Brian, additional, Dominique, Brisot, additional, Christophe, Brousse, additional, Trimarco, Bruno, additional, Luo, Canhua, additional, Cuneo, Carlos Alberto, additional, Diaz, Carlos Jerjes Sanchez, additional, Schwencke, Carsten, additional, Cader, Cas, additional, Yavuz, Celal, additional, Zaidman, Cesar Javier, additional, Lunn, Charles, additional, Wu, Chau-Chung, additional, Toh, Cheng Hock, additional, Elisa, Chevrier, additional, Hsia, Chien-Hsun, additional, Huang, Chien-Lung, additional, Kwok, Chi-Hang Kevin, additional, Wu, Chih-Cheng, additional, Huang, Chi-Hung, additional, Ward, Chris, additional, Opitz, Christian, additional, Jeanneret-Gris, Christina, additional, Ha, Chung Yin, additional, Huang, Chun-Yao, additional, Bidi, Claude Luyeye, additional, Smith, Clifford, additional, Brauer, Cornelia, additional, Lodigiani, Corrado, additional, Francis, Couturaud, additional, Wu, Cynthia, additional, Staub, Daniel, additional, Theodoro, Daniel, additional, Poli, Daniela, additional, Acevedo, David - Riesco, additional, Adler, David, additional, Jimenez, David, additional, Keeling, David, additional, Scott, David, additional, Imberti, Davide, additional, Creagh, Desmond, additional, Helene, Desmurs-Clavel, additional, Hagemann, Dirk, additional, Le Roux, Dirk, additional, Skowasch, Dirk, additional, Belenky, Dmitry, additional, Dorokhov, Dmitry, additional, Petrov, Dmitry, additional, Zateyshchikov, Dmitry, additional, Prisco, Domenico, additional, Møller, Dorthe, additional, Kucera, Dusan, additional, Esheiba, Ehab M., additional, Panchenko, Elizaveta, additional, Dominique, Elkouri, additional, Dogan, Emre, additional, Kubat, Emre, additional, Diaz, Enrique Diaz, additional, Tse, Eric Wai Choi, additional, Yeo, Erik, additional, Hashas, Erman, additional, Grochenig, Ernst, additional, Tiraferri, Eros, additional, Blessing, Erwin, additional, Michèle, Escande Orthlieb, additional, Usandizaga, Esther, additional, Porreca, Ettore, additional, Ferroni, Fabian, additional, Nicolas, Falvo, additional, Ayala-Paredes, Félix, additional, Koura, Firas, additional, Henry, Fitjerald, additional, Cosmi, Franco, additional, Erdkamp, Frans, additional, Kamalov, Gadel, additional, Dalmau, Garcia-Bragado, additional, Damien, Garrigues, additional, Klein, Garry, additional, Shah, Gaurand, additional, Hollanders, Geert, additional, Merli, Geno, additional, Plassmann, Georg, additional, Platt, George, additional, Poirier, Germain, additional, Sokurenko, German, additional, Haddad, Ghassan, additional, Ali, Gholam, additional, Agnelli, Giancarlo, additional, Gan, Gin Gin, additional, Kaye-Eddie, Grace, additional, Le Gal, Gregoire, additional, Allen, Gregory, additional, Esperón, Guillermo Antonio Llamas, additional, Jean-Paul, Guillot, additional, Gerofke, Hagen, additional, Elali, Hallah, additional, Burianova, Hana, additional, Ohler, Hans-Juergen, additional, Wang, Haofu, additional, Darius, Harald, additional, Gogia, Harinder S., additional, Striekwold, Harry, additional, Hasanoglu, Hatice, additional, Turker, Hatice, additional, Franow, Hendrik, additional, De Raedt, Herbert, additional, Schroe, Herman, additional, ElDin, Hesham Salah, additional, Zidan, Hesham, additional, Nakamura, Hiroaki, additional, Kim, Ho Young, additional, Lawall, Holger, additional, Zhu, Hong, additional, Tian, Hongyan, additional, Yhim, Ho-Young, additional, Hwang, Hun Gyu, additional, Shim, Hyeok, additional, Kim, Igor, additional, Libov, Igor, additional, Sonkin, Igor, additional, Suchkov, Igor, additional, Song, Ik-Chan, additional, Kiris, Ilker, additional, Staroverov, Ilya, additional, Looi, Irene, additional, De La Azuela Tenorio, Isabel M., additional, Savas, Ismail, additional, Gordeev, Ivan, additional, Podpera, Ivo, additional, Lee, Jae Hoon, additional, Sathar, Jameela, additional, Welker, James, additional, Beyer-Westendorf, Jan, additional, Kvasnicka, Jan, additional, Vanwelden, Jan, additional, Kim, JangYong, additional, Svobodova, Jaromira, additional, Gujral, Jaspal, additional, Marino, Javier, additional, Galvar, Javier Tristan, additional, Kassis, Jeannine, additional, Kuo, Jen-Yuan, additional, Shih, Jhih-Yuan, additional, Kwon, JiHyun, additional, Joh, Jin Hyun, additional, Park, Jin Hyun, additional, Kim, Jin Seok, additional, Yang, Jinghua, additional, Krupicka, Jiri, additional, Lastuvka, Jiri, additional, Pumprla, Jiri, additional, Vesely, Jiri, additional, Souto, Joan Carlos, additional, Correa, João Antônio, additional, Duchateau, Johan, additional, Fletcher, John Perry, additional, del Toro, Jorge, additional, Paez, Jorge Guillermo Chavez, additional, Nielsen, Jørn, additional, Filho, Jose Dalmo Araujo, additional, Saraiva, Jose, additional, Peromingo, Jose Antonio Diaz, additional, Lara, Jose Gomez, additional, Fedele, Jose Luis, additional, Surinach, Jose Maria, additional, Chacko, Joseph, additional, Muntaner, Juan Antonio, additional, Benitez, Juan Carlos Álvarez, additional, Abril, Juan Moreno Hoyos, additional, Humphrey, Julian, additional, Bono, Julio, additional, Kanda, Junji, additional, Boondumrongsagoon, Juree, additional, Yiu, Kai Hang, additional, Chansung, Kanchana, additional, Boomars, Karin, additional, Burbury, Kate, additional, Kondo, Katsuhiro, additional, Karaarslan, Kemal, additional, Takeuchi, Kensuke, additional, Kroeger, Knut, additional, Zrazhevskiy, Konstantin, additional, Svatopluk, Koscál, additional, Shyu, Kou-Gi, additional, Vandenbosch, Kristel, additional, Chang, Kuan-Cheng, additional, Chiu, Kuan-Ming, additional, Jean-Manuel, Kubina, additional, Wern, Kwan Jing, additional, Ueng, Kwo-Chang, additional, Norasetthada, Lalita, additional, Binet, Laure, additional, Chew, Lee Ping, additional, Zhang, Lei, additional, Cristina, Leone Maria, additional, Tick, Lidwine, additional, Schiavi, Lilia Beatriz, additional, Wong, Lily Lee Lee, additional, Borges, Lohana, additional, Botha, Louis, additional, Capiau, Luc, additional, Timmermans, Luc, additional, López, Luciano Eduardo, additional, Ria, Luigi, additional, Blasco, Luis Manuel Hernandez, additional, Guzman, Luis Alberto, additional, Cervera, Luis Flota, additional, Isabelle, Mahe, additional, Bosch, Manuel Monreal, additional, de los Rios Ibarra, Manuel, additional, Fernandez, Manuel Núñez, additional, Carrier, Marc, additional, Barrionuevo, Marcelo Raul, additional, Gamba, Marco Antonio Alcocer, additional, Cattaneo, Marco, additional, Moia, Marco, additional, Bowers, Margaret, additional, Chetanachan, Mariam, additional, Berli, Mario Alberto, additional, Fixley, Mark, additional, Faghih, Markus, additional, Stuecker, Markus, additional, Schul, Marlin, additional, Banyai, Martin, additional, Koretzky, Martin, additional, Myriam, Martin, additional, Gaffney, Mary Elizabeth, additional, Hirano, Masao, additional, Kanemoto, Masashi, additional, Nakamura, Mashio, additional, Tahar, Mersel, additional, Emmanuel, Messas, additional, Kovacs, Michael, additional, Leahy, Michael, additional, Levy, Michael, additional, Munch, Michael, additional, Olsen, Michael, additional, De Pauw, Michel, additional, Gustin, Michel, additional, Van Betsbrugge, Michiel, additional, Boyarkin, Mikhail, additional, Homza, Miroslav, additional, Koto, Modise, additional, Abdool-Gaffar, Mohamed, additional, Nagib, Mohamed Ayman Fakhry, additional, El-Dessoki, Mohamed, additional, Khan, Mohamed, additional, Mohamed, Monniaty, additional, Kim, Moo Hyun, additional, Lee, Moon-Hee, additional, Soliman, Mosaad, additional, Ahmed, Mostafa Shawky, additional, el Bary, Mostafa Soliman Abd, additional, Moustafa, Moustafa A., additional, Hameed, Muhammad, additional, Kanko, Muhip, additional, Majumder, Mujibur, additional, Zubareva, Nadezhda, additional, Mumoli, Nicola, additional, Abdullah, Nik Azim Nik, additional, Makruasi, Nisa, additional, Paruk, Nishen, additional, Kanitsap, Nonglak, additional, Duda, Norberto, additional, Nordin, Nordiana, additional, Nyvad, Ole, additional, Barbarash, Olga, additional, Gurbuz, Orcun, additional, Vilamajo, Oscar Gomez, additional, Flores, Oscar Nandayapa, additional, Gur, Ozcan, additional, Oto, Oztekin, additional, Marchena, Pablo Javier, additional, Carroll, Patrick, additional, Lang, Pavel, additional, MacCallum, Peter, additional, von Bilderling, Peter Baron, additional, Blombery, Peter, additional, Jansky, Petr, additional, Bernadette, Peuch, additional, De Vleeschauwer, Philippe, additional, Hainaut, Philippe, additional, Ferrini, Piera Maria, additional, Iamsai, Piriyaporn, additional, Christian, Ponchaux, additional, Viboonjuntra, Pongtep, additional, Rojnuckarin, Ponlapat, additional, Ho, Prahlad, additional, Mutirangura, Pramook, additional, Wells, Rachel, additional, Martinez, Rafael, additional, Miranda, Raimundo Tirado, additional, Kroening, Ralf, additional, Ratsela, Rapule, additional, Reyes, Raquel Lopez, additional, de Leon, Raul Franco Diaz, additional, Wong, Raymond Siu Ming, additional, Alikhan, Raz, additional, Jerwan-Keim, Reinhold, additional, Otero, Remedios, additional, Murena-Schmidt, Renate, additional, Canevascini, Reto, additional, Ferkl, Richard, additional, White, Richard, additional, Van Herreweghe, Rika, additional, Santoro, Rita, additional, Klamroth, Robert, additional, Mendes, Robert, additional, Prosecky, Robert, additional, Cappelli, Roberto, additional, Spacek, Rudolf, additional, Singh, Rupesh, additional, Griffin, Sam, additional, Na, Sang Hoon, additional, Chunilal, Sanjeev, additional, Middeldorp, Saskia, additional, Nakazawa, Satoshi, additional, Toh, See Guan, additional, Christophe, Seinturier, additional, Isbir, Selim, additional, Raymundo, Selma, additional, Ting, Seng Kiat, additional, Motte, Serge, additional, Aktogu, Serir Ozkan, additional, Donders, Servaas, additional, Cha, Seung Ick, additional, Nam, Seung-Hyun, additional, Marie-Antoinette, Sevestre-Pietri, additional, Maasdorp, Shaun, additional, Sun, Shenghua, additional, Wang, Shenming, additional, Essameldin, Sherif Mohamed, additional, Sholkamy, Sherif Mohamed, additional, Kuki, Shintaro, additional, Yoshida, Shuichi, additional, Matsuoka, Shunzo, additional, McRae, Simon, additional, Watt, Simon, additional, Patanasing, Siriwimon, additional, Jean-Léopold, Siwe-Nana, additional, Wongkhantee, Somchai, additional, Bang, Soo-Mee, additional, Testa, Sophie, additional, Zemek, Stanislav, additional, Behrens, Steffen, additional, Dominique, Stephan, additional, Mellor, Stuart, additional, Singh, Suaran Singh Gurcharan, additional, Datta, Sudip, additional, Chayangsu, Sunee, additional, Solymoss, Susan, additional, Everington, Tamara, additional, Abdel-Azim, Tarek Ahmed Adel, additional, Suwanban, Tawatchai, additional, Adademir, Taylan, additional, Hart, Terence, additional, Béatrice, Terriat, additional, Luvhengo, Thifhelimbilu, additional, Horacek, Thomas, additional, Zeller, Thomas, additional, Boussy, Tim, additional, Reynolds, Tim, additional, Biss, Tina, additional, Chao, Ting-Hsing, additional, Casabella, Tomas Smith, additional, Onodera, Tomoya, additional, Numbenjapon, Tontanai, additional, Gerdes, Victor, additional, Cech, Vladimir, additional, Krasavin, Vladimir, additional, Tolstikhin, Vladimir, additional, Bax, W.A., additional, Malek, Wagih Fawzy Abdel, additional, Ho, Wai Khoon, additional, Pharr, Walter, additional, Jiang, Weihong, additional, Lin, Wei-Hsiang, additional, Zhang, Weihua, additional, Tseng, Wei-Kung, additional, Lai, Wen-Ter, additional, De Backer, Wilfried, additional, Haverkamp, Wilhelm, additional, Yoshida, Winston, additional, Korte, Wolfgang, additional, Choi, Won Il, additional, Kim, Yang-Ki, additional, Tanabe, Yasuhiro, additional, Ohnuma, Yasushi, additional, Mun, Yeung-Chul, additional, Balthazar, Yohan, additional, Park, Yong, additional, Shibata, Yoshisato, additional, Burov, Yuriy, additional, Subbotin, Yuriy, additional, Coufal, Zdenek, additional, Yang, Zhenwen, additional, Jing, Zhicheng, additional, and Yang, Zhongqi, additional

Published
2023
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34. Management of anticoagulation in atrial fibrillation patients in Italy: insight from the Atrial Fibrillation-Survey on Anticoagulated Patients Register (AF-START).

Author

Poli, Daniela, Ageno, Walter, Antonucci, Emilia, Bradamante, Salvatore, Bucherini, Eugenio, Chiarugi, Paolo, Chistolini, Antonio, Cosmi, Benilde, Falanga, Anna, Insana, Antonio, Lione, Domenico, Maria Lombardi, Rosa, Malcangi, Giuseppe, Marcucci, Rossella, Martini, Giuliana, Masciocco, Lucilla, Paparo, Carmelo, Pastori, Daniele, Pedrini, Simona, and Pengo, Vittorio

Subjects
ATRIAL fibrillation, ANTICOAGULANTS, ORAL medication
Abstract

The survey on anticoagulated patients register (START-Register) is an independent, prospective, inception-cohort observational study aimed at providing information on patients on vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) in Italy. In this study, we describe the cohort of atrial fibrillation (AF) patients in the START-Register and report outcomes and changes in anticoagulant prescription from 2011 to 2021. The study included 11,078 AF patients, enrolled in 47 Italian centers distributed all over the Country; the median age was 77 years (range 18-99 years); 6,029 (54.3%) were men; 5,135 (46.4%) were on VKAs, and 5,943 (53.6%) were on DOACs. Warfarin was the most prescribed VKA (98.4%), and apixaban was the most prescribed DOAC (31.6%). Among DOAC users, 4,022 (67.7%) patients were naive to anticoagulation, and 2,562 (43.1%) patients were treated with a reduced dose. DOAC patients were significantly older than VKA patients (median age 79 years vs 76 years respectively, P<0.001), but no gender difference was detected. The mean CHA2DS2VASc score was higher in DOAC users than in VKA users (3.7 vs 3.6; P=0.03). The mean HAS-BLED score was not different between the two groups. During follow-up, 542 bleeding events were recorded [2.44 per 100 patient-years (pt-yrs)]; 240 were major (1.08 per 100 pt-yrs), and 301 were clinically relevant nonmajor bleedings (1.34 per 100 pt-yrs). 146 thrombotic events were recorded during follow-up (0.66 per 100 pt-yrs). The total mortality rate was 3.5 per 100 pt-yrs; the mortality rate was 4.54 per 100 pt-yrs among patients on VKAs and 2.31 per 100 pt-yrs among patients on DOACs. During the last 10 years, in Italy, AF patient management has changed with the large spread of DOACs all over the Country. DOAC patients are frequently treated with reduced doses and show a lower mortality rate in comparison to patients on VKAs. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Capsular Warning Syndrome: Features, Risk Profile, and Prognosis in a Large Prospective TIA Cohort.

Author

Foschi, Matteo, Pavolucci, Lucia, Rondelli, Francesca, Barone, Valentina, Rinaldi, Rita, Spinardi, Luca, Favaretto, Elisabetta, Rucci, Paola, Giostra, Fabrizio, Cosmi, Benilde, Borghi, Claudio, Cortelli, Pietro, and Guarino, Maria

Subjects
LACUNAR stroke, STROKE, PROGNOSIS, CEREBRAL hemorrhage, PLATELET aggregation inhibitors, ATRIAL fibrillation
Abstract

Introduction: Features and prognosis of capsular warning syndrome (CWS) have been poorly investigated prospectively. Aims: The study aimed to characterize CWS clinical features, risk profile, short- and long-term prognosis, among a large TIA cohort. Methods: Prospective cohort study of consecutive TIAs was conducted from August 1, 2010, to December 31, 2017. Demographic and clinical characteristics, risk profile, primary (stroke and composite outcome) and secondary (TIA recurrence, cerebral hemorrhage, new onset atrial fibrillation) outcomes were compared between CWS, lacunar (L), and nonlacunar (NL) TIAs. Results: 1,035 patients (33 CWS, 189 L-TIAs, 813 NL-TIAs) were enrolled. Newly diagnosed (ND) hypertension, hypercholesterolemia, cigarette smoking, and leukoaraiosis were independent risk factors of CWS (p < 0.05). CWS showed the highest stroke (30.3% vs. 0.5% and 1.5% for L-TIAs and NL-TIAs, respectively) and composite outcome risk at follow-up (p < 0.001), but better 3-month post-stroke prognosis (mRS 0–2 90.0% vs. 36.8%; p = 0.002). CWS-related stroke mostly occurred <48 h (80.0%) and had a small vessel occlusion etiology (100%), affecting more often the internal capsule (60.0%). Dual antiplatelet therapy (DAPT) versus single antiplatelet therapy was associated with lower 3-month cumulative stroke incidence (12.5% vs. 57.1%; p = 0.010). Intravenous thrombolysis (IVT) showed similar 3-month efficacy and safety in strokes after TIAs groups (median mRS 0, IQR 0–1; p = 0.323). Conclusions: CWS is associated with higher stroke risk and better functional prognosis than L- and NL-TIAs. CWS risk profile is consistent with severe small vessel disease, and ND hypertension could represent a major risk factor. DAPT and IVT seem effective and safe in preventing and treating stroke following CWS. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Rationale and design of a study on D-dimer use to stratify patients after a first unprovoked venous thromboembolism for their risk of recurrence: extended low-dose Apixaban given only to patients with positive D-dimer results

Author

Palareti, Gualtiero, primary, Prandoni, Paolo, additional, Legnani, Cristina, additional, Antonucci, Emilia, additional, Zorzi, Serena, additional, Tosetto, Alberto, additional, Bertù, Lorenza, additional, Testa, Sophie, additional, Pengo, Vittorio, additional, Ageno, Walter, additional, Martinelli, Ida, additional, Cosmi, Benilde, additional, Bucherini, Eugenio, additional, and Poli, Daniela, additional

Published
2022
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42. The Post-thrombotic Syndrome-Prevention and Treatment: VAS-European Independent Foundation in Angiology/Vascular Medicine Position Paper

Author

Cosmi, Benilde, primary, Stanek, Agata, additional, Kozak, Matja, additional, Wennberg, Paul W., additional, Kolluri, Raghu, additional, Righini, Marc, additional, Poredos, Pavel, additional, Lichtenberg, Michael, additional, Catalano, Mariella, additional, De Marchi, Sergio, additional, Farkas, Katalin, additional, Gresele, Paolo, additional, Klein-Wegel, Peter, additional, Lessiani, Gianfranco, additional, Marschang, Peter, additional, Pecsvarady, Zsolt, additional, Prior, Manlio, additional, Puskas, Attila, additional, and Szuba, Andrzej, additional

Published
2022
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45. Long-term Risk of Recurrent Venous Thromboembolism Among Patients Receiving Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S, Kearon, Clive, Weitz, Jeffrey I, Büller, Harry R, Raskob, Gary E, Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A, Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert-Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A, Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W A, Gebel, Martin, Grosso, Michael A, Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Subjects
cardiovascular diseases, equipment and supplies
Abstract

BACKGROUND The long-term risk for recurrent venous thromboembolism (VTE) during extended anticoagulation for a first unprovoked VTE is uncertain. OBJECTIVES To determine the incidence of recurrent VTE during extended anticoagulation up to 5 years in patients with a first unprovoked VTE. METHODS MEDLINE, EMBASE, and the Cochrane CENTRAL were searched to identify randomized trials and prospective cohort studies reporting recurrent VTE among patients with a first unprovoked VTE who were to receive anticoagulation for a minimum of 6 additional months after completing ≥ 3 months of initial treatment. Unpublished data on number of recurrent VTE and person-years, obtained from authors of included studies, were used to calculate study-level incidence rate, and random-effects meta-analysis was used to pool results. RESULTS Twenty-six studies and 15, 603 patients were included in the analysis. During 11, 631 person-years of follow-up, the incidence of recurrent VTE and fatal pulmonary embolism per 100 person-years was 1.41 (95% CI, 1.03-1.84) and 0.09 (0.04-0.16), with 5-year cumulative incidences of 7.1% (3.0%-13.2%) and 1.2% (0.4%-4.6%), respectively. The incidence of recurrent VTE was 1.08 (95% CI, 0.77-1.44) with direct oral anticoagulants and 1.55 (1.01-2.20) with vitamin K antagonists. The case-fatality rate of recurrent VTE was 4.9% (95% CI, 2.2%-8.7%). CONCLUSIONS In patients with a first unprovoked VTE, the long-term risk of recurrent VTE during extended anticoagulation is low but not negligible. Thus, clinicians and patients should be aware of this risk and take appropriate and timely action in case of suspicion of recurrent VTE. Estimates from this study can be used to advise patients on what to expect while receiving extended anticoagulation, and estimate the net clinical benefit of extended treatment to guide long-term management of unprovoked VTE.

Published
2021

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