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2. Resting-state functional MRI in multicenter studies on multiple sclerosis: a report on raw data quality and functional connectivity features from the Italian Neuroimaging Network Initiative

Author

De Rosa, A. P., Esposito, F., Valsasina, P., D’Ambrosio, A., Bisecco, A., Rocca, M. A., Tommasin, S., Marzi, C., De Stefano, N., Battaglini, M., Pantano, P., Cirillo, M., Tedeschi, G., Filippi, M., Gallo, A., the INNI Network, Altieri, M., Borgo, R., Capuano, R., Storelli, L., Pagani, E., Sibilia, M., Piervincenzi, C., Ruggieri, S., Petsas, N., Cortese, R., Stromillo, M. L., De Rosa, Alessandro Pasquale, Esposito, Fabrizio, Valsasina, Paola, D'Ambrosio, Alessandro, Bisecco, Alvino, Rocca, Maria A, Tommasin, Silvia, Marzi, Chiara, De Stefano, Nicola, Battaglini, Marco, Pantano, Patrizia, Cirillo, Mario, Tedeschi, Gioacchino, Filippi, Massimo, and Gallo, Antonio

Subjects
Multiple sclerosis, Functional connectivity, Neurology, Functional magnetic resonance imaging, Quality control, Multiple sclerosi, MS, Neurology (clinical), MRI
Abstract

The Italian Neuroimaging Network Initiative (INNI) is an expanding repository of brain MRI data from multiple sclerosis (MS) patients recruited at four Italian MRI research sites. We describe the raw data quality of resting-state functional MRI (RS-fMRI) time-series in INNI and the inter-site variability in functional connectivity (FC) features after unified automated data preprocessing. MRI datasets from 489 MS patients and 246 healthy control (HC) subjects were retrieved from the INNI database. Raw data quality metrics included temporal signal-to-noise ratio (tSNR), spatial smoothness (FWHM), framewise displacement (FD), and differential variation in signals (DVARS). Automated preprocessing integrated white-matter lesion segmentation (SAMSEG) into a standard fMRI pipeline (fMRIPrep). FC features were calculated on pre-processed data and harmonized between sites (Combat) prior to assessing general MS-related alterations. Across centers (both groups), median tSNR and FWHM ranged from 47 to 84 and from 2.0 to 2.5, and median FD and DVARS ranged from 0.08 to 0.24 and from 1.06 to 1.22. After preprocessing, only global FC-related features were significantly correlated with FD or DVARS. Across large-scale networks, age/sex/FD-adjusted and harmonized FC features exhibited both inter-site and site-specific inter-group effects. Significant general reductions were obtained for somatomotor and limbic networks in MS patients (vs. HC). The implemented procedures provide technical information on raw data quality and outcome of fully automated preprocessing that might serve as reference in future RS-fMRI studies within INNI. The unified pipeline introduced little bias across sites and appears suitable for multisite FC analyses on harmonized network estimates.

Published
2022
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6. Fundbericht 2022 — Chronique archéologique 2022 — Cronaca archeologica 2022

Author

Ackermann, R., Aebersold, S., Allemann, H., Amoroso, H., Andereggen, M., André, I., Andres, B., Ansermet, Ch., Aschwanden, S., Auf der Maur, Ch., Baerlocher, J., Balet, J., Baur, Ch., Beeler, P., Benazeth, I., Bertschi, M., Berweger, M., Bondi, C., Braillard, S., Bregnard, L., Brenet, F., Broillet-Ramjoué, E., Bucher, J., Bucher, R., Buess, M., Burkhardt, L., Cardani Vergani, R., Casaulta, M., Chamberlain, S., Chaudet, V., Chauvière, F.-X., Chevassu, V., Colaizzi, I., Consagra, G., Constantin, Th., Cornelissen, M., Cortese, R., de Chambrier, A., de Weck, A., Deák, J., Debard, J., Desarzens, N., Dorthe, A., Doswald, St., Fahrni, M.-J., Fallet, C., Fankhauser, J., Fischer, A., Flück, M., Freitag, A., Freitag, L., Frey, J., Gallay, A., Gantner, M., Gerber, Ch., Giger, M., Gillioz, M., Giozza, G., Glaus, M., Gollnick, U., Graber, S., Grutsch, C., Guex, M.-P., Guichon, R., Gut, C., Harb, Ch., Hart, B., Heinzle, B., Held, J., Henny, Ch., Hertig, N., Hervé, C., Heubi, O., Hodel, C., Höpfer, B., Huber, A., Huber, R., Imhof, W., Jakob, B., Janke, R., Javet, R., Jecker, D., Jobin, P., Junod, O., Käch, D., Kaufmann, S., Kienholz, A., Kissling, C., Klingen, S., Koch, P., König, K., Kramer, L., Kraus, S., Kündig, Ch., Langenegger, F., Lanthemann, F., Lanzicher, A. F., Leuzinger, U., Liboutet, M., Liechti, U., Locatelli, D., Löckher, C., Luisoni, G., Lüscher, R., Maciejczak, M., Maibach, J., Maise, Ch., Margot, W., Maroelli, D., Marti, A., Marti, R., Martin, E., McCullough, F., Meier Mohamed, G., Menna, F., Messner, F., Michel, Ch., Monnier, J., Mosetti, L., Motschi, A., Müller, W., Näf, N., Nagy, P., Nicolet, G., Nieberle, M., Nogara, G., Oberhänsli, M., Obrecht, J., Papucci, L., Pedrucci, A., Peter, M., Petit, X., Pfyffer, J., Pignolet, A., Pilloud, R., Pittet, B., Pradervand, A.-L., Presset, O., Reinhard, J., Reitmaier-Naef, L., Reitmaier, Th., Richner, L., Rubeli, L., Rüedi, K., Ruffieux, M., Savary, J., Schaeren, G., Schäppi, K., Schärer, L., Scheiber, E., Schenk, A., Schindler, M. P., Schmelzbach, C., Schmidig, R., Schmidt, V., Schopfer, A., Schwind, S., Segond, A.-L., Sele, R., Signer, A., Sliwinski, A., Spielmann, J., Spiess, C., Steiner, L., Steinhauser, R., Șuteu, C., Tenud, A., Thomas, P., Thorimbert, S., Tortoli, F., Trumm, J., Tuchschmid, F., van Willigen, S., Vigneau, H., von Wartburg, J., Wälchi, D., Walser, Ch., Wegmüller, F., Wimmer, J., Winkler, A., Wulf, D., and Wyss, B.

Abstract

Der archäologische Fundbericht enthält Nachrichten und Notizen über Neufunde und Grabungen in der Schweiz. Wir danken allen Autoren, die Beiträge und Bildmaterial zur Verfügung gestellt haben. La chronique archéologique renseigne sur des fouilles et des découvertes récentes en Suisse. Nous remercions tous ceux qui ont mis à notre disposition leurs rapports et leurs illustrations. La cronaca archeologica informa su scoperte recenti e scavi in Svizzera. A tutti lizzare le loro relazioni e documentazioni fotografiche.

Published
2023
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15. A multicentric investigation of the diagnostic accuracy of cortical lesions and central vein sign in multiple sclerosis

Author

Cagol, A., Cortese, R., Barakovic, M., Schaedelin, S., Ruberte, E., Absinta, M., Barkhof, F., Calabrese, M., Marco Castellaro, Ciccarelli, O., Cocozza, S., Stefano, N., Enzinger, C., Filippi, M., Jurynczyk, M., Maggi, P., Mahmoudi, N., Montalban, X., Palace, J., Pontillo, G., Rocca, M. A., Ropele, S., Rovira, A., Schoonheim, M. M., Sowa, P., Strijbis, E., Wattjes, M. P., Wuerfel, J., Kappos, L., and Granziera, C.

Published
2022

19. Cover profile: How comparable are microbial electrochemical systems around the globe? An electrochemical and microbiological cross‐laboratory study

Author

Santoro, C., Babanova, S., Cristiani, P., Artyushkova, K., Atanassov, P., Bergel, A., Bretschger, O., Brown, R.K., Carpenter, K., Colombo, A., Cortese, R., Erable, B., Harnisch, Falk, Kodali, M., Phadke, S., Riedl, S., Rosa, Luis Filipe Morgado, Schröder, U., Santoro, C., Babanova, S., Cristiani, P., Artyushkova, K., Atanassov, P., Bergel, A., Bretschger, O., Brown, R.K., Carpenter, K., Colombo, A., Cortese, R., Erable, B., Harnisch, Falk, Kodali, M., Phadke, S., Riedl, S., Rosa, Luis Filipe Morgado, and Schröder, U.

Abstract

no abstract

Published
2021

29. Viral Vector Malaria Vaccines Induce High-Level T Cell and Antibody Responses in West African Children and Infants

Author

Bliss, CM, Drammeh, A, Bowyer, G, Sanou, GS, Jagne, YJ, Ouedraogo, O, Edwards, NJ, Tarama, C, Ouedraogo, N, Ouedraogo, M, Njie-Jobe, J, Diarra, A, Afolabi, MO, Tiono, AB, Yaro, JB, Adetifa, UJ, Hodgson, SH, Anagnostou, NA, Roberts, R, Duncan, CJA, Cortese, R, Viebig, NK, Leroy, O, Lawrie, AM, Flanagan, KL, Kampmann, B, Imoukhuede, EB, Sirima, SB, Bojang, K, Hill, AVS, Nebie, I, and Ewer, KJ

Subjects
T-Lymphocytes, Antibodies, Protozoan, Research & Experimental Medicine, 10 Technology, vaccine, INFECTION, Drug Discovery, antibodies, Malaria, Falciparum, Child, Genetics & Heredity, MVA ME-TRAP, Immunity, Cellular, PLASMODIUM-FALCIPARUM, Vaccination, 11 Medical And Health Sciences, Flow Cytometry, IMMUNIZATION, Immunoglobulin Isotypes, Africa, Western, Medicine, Research & Experimental, Child, Preschool, Molecular Medicine, Original Article, Female, Life Sciences & Biomedicine, Biotechnology, CIRCUMSPOROZOITE PROTEIN, viral vectors, ANTIGEN, Genetic Vectors, Plasmodium falciparum, malaria, T cells, Enzyme-Linked Immunosorbent Assay, EARLY-LIFE, Phase I trial, AGE, Malaria Vaccines, parasitic diseases, Genetics, Humans, Molecular Biology, Pharmacology, Science & Technology, Infant, Newborn, Infant, 06 Biological Sciences, EFFICACY, Immunity, Humoral, Biotechnology & Applied Microbiology
Abstract

Heterologous prime-boosting with viral vectors encoding the pre-erythrocytic antigen thrombospondin-related adhesion protein fused to a multiple epitope string (ME-TRAP) induces CD8+ T cell-mediated immunity to malaria sporozoite challenge in European malaria-naive and Kenyan semi-immune adults. This approach has yet to be evaluated in children and infants. We assessed this vaccine strategy among 138 Gambian and Burkinabe children in four cohorts: 2- to 6-year olds in The Gambia, 5- to 17-month-olds in Burkina Faso, and 5- to 12-month-olds and 10-week-olds in The Gambia. We assessed induction of cellular immunity, taking into account the distinctive hematological status of young infants, and characterized the antibody response to vaccination. T cell responses peaked 7 days after boosting with modified vaccinia virus Ankara (MVA), with highest responses in infants aged 10 weeks at priming. Incorporating lymphocyte count into the calculation of T cell responses facilitated a more physiologically relevant comparison of cellular immunity across different age groups. Both CD8+ and CD4+ T cells secreted cytokines. Induced antibodies were up to 20-fold higher in all groups compared with Gambian and United Kingdom (UK) adults, with comparable or higher avidity. This immunization regimen elicited strong immune responses, particularly in young infants, supporting future evaluation of efficacy in this key target age group for a malaria vaccine., An effective malaria vaccine is an urgent global health priority. In these studies, Ewer and colleagues describe strong T cell and antibody responses in children and infants following vaccination with a viral vectored vaccine regime encoding a pre-erythrocytic malaria antigen. This regime has previously demonstrated efficacy in adults and these data support assessment of the efficacy of this vaccine in infants.

Published
2017
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31. A first-in-human study of the novel HIV-fusion inhibitor C34-PEG4-Chol

Author

Quinn, K, Traboni, C, Dily Penchala, S, Bouliotis, G, Doyle, N, Libri, V, Khoo, S, Ashby, D, Weber, J, Nicosia, A, Cortese, R, Pessi, A, Winston, A, Quinn, K, Traboni, C, Penchala, Sd, Bouliotis, G, Doyle, N, Libri, V, Khoo, S, Ashby, D, Weber, J, Nicosia, A, Cortese, R, Pessi, Annalisa, Winston, A., and Medical Research Council (MRC)

Subjects
lcsh:R, lcsh:Medicine, lcsh:Q, lcsh:Science
Abstract

Long-acting injectable antiretroviral (LA-ARV) drugs with low toxicity profiles and propensity for drug-drug interactions are a goal for future ARV regimens. C34-PEG4-Chol is a novel cholesterol tagged LA HIV-fusion-inhibitor (FI). We assessed pre-clinical toxicology and first-in-human administration of C34-PEG4-Chol. Pre-clinical toxicology was conducted in 2 species. HIV-positive men were randomised to a single subcutaneous dose of C34-PEG4-Chol at incrementing doses or placebo. Detailed clinical (including injection site reaction (ISR) grading), plasma pharmacokinetic (time-to-minimum-effective-concentration (MEC, 25 ng/mL) and pharmacodynamic (plasma HIV RNA) parameters were assessed. In both mice and dogs, no-observed-adverse effect level (NOAEL) was observed at a 12 mg/kg/dose after two weeks. Of 5 men enrolled, 3 received active drug (10 mg, 10 mg and 20 mg). In 2 individuals grade 3 ISR occurred and the study was halted. Both ISR emerged within 12 hours of active drug dosing. No systemic toxicities were observed. The time-to-MEC was >72 and >96 hours after 10 and 20 mg dose, respectively, and mean change in HIV RNA was −0.9 log10 copies/mL. These human pharmacodynamic and pharmacokinetic data, although limited to 3 subjects, of C34-PEG-4-Chol suggest continuing evaluation of this agent as a LA-ARV. However, alternative administration routes must be explored.

Published
2017

33. Brain and spinal cord atrophy in NMOSD and MOGAD: Current evidence and future perspectives.

Author

Lorefice, L. and Cortese, R.

Abstract

• NMOSD and MOGAD frequently occur with a relapsing course. • Recent studies have proposed the existence of subclinical pathological processes outside of acute episodes. • In MS, brain and spinal cord volumes has long been considered a valuable outcome measure. • The review examined the key studies on MRI measurements in adult patients with NMOSD and MOGAD. • We discuss differences with MS, current challenges and future perspectives. Neuromyelitis optica spectrum disorder (NMOSD) is a severe form of inflammation of the central nervous system (CNS) including acute myelitis, optic neuritis and brain syndrome. Currently, the classification of NMOSD relies on serologic testing, distinguishing between seropositive or seronegative anti-aquaporin-4 antibody (AQP4) status. However, the situation has recently grown more intricate with the identification of patients exhibiting the NMOSD phenotype and myelin oligodendrocyte glycoprotein antibodies (MOGAD). NMOSD is primarily recognized as a relapsing disorder; MOGAD can manifest with either a monophasic or relapsing course. Significant symptomatic inflammatory CNS injuries with stability in clinical findings outside the acute phase are reported in both diseases. Nevertheless, recent studies have proposed the existence of a subclinical pathological process, revealing longitudinal changes in brain and spinal cord atrophy. Within this context, we summarise key studies investigating brain and spinal cord measurements in adult NMOSD and MOGAD. We also explore their relationship with clinical aspects, highlight differences from multiple sclerosis (MS), and address future challenges. This exploration is crucial for determining the presence of chronic damage processes, enabling the customization of therapeutic interventions irrespective of the acute phase of the disease. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome:A MAGNIMS multicentre study

Author

Hagens, M, Burggraaff, J, Kilsdonk, I, Ruggieri, S, Collorone, S, Cortese, R, Cawley, N, Sbardella, E, Andelova, M, Amann, M, Lieb, J, Pantano, P, Lissenberg-Witte, B, Killestein, J, Oreja-Guevara, C, Wuerfel, J, Ciccarelli, O, Gasperini, C, Lukas, C, Rovira, A, Barkhof, F, Wattjes, M, Group, MAGNIMS Study, Palace, J, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, NCA - Neuroinflamation, AII - Inflammatory diseases, Radiology and nuclear medicine, Epidemiology and Data Science, APH - Methodology, and Other Research

Subjects
Adult, Male, medicine.medical_specialty, interobserver variation, Neuroimaging, Multiple sclerosis, clinically isolated syndrome, magnetic resonance imaging, multicentre study, 03 medical and health sciences, 0302 clinical medicine, Radiologists, Brain mri, medicine, Humans, Clinical significance, 030212 general & internal medicine, Neurologists, Clinically isolated syndrome, medicine.diagnostic_test, Lesion detection, business.industry, Clinical Competence, Demyelinating Diseases, Female, Follow-Up Studies, Magnetic Resonance Imaging, Middle Aged, Magnetic resonance imaging, medicine.disease, Neurology, Cohort, Dissemination in space, Neurology (clinical), Radiology, business, Original Research Papers, 030217 neurology & neurosurgery
Abstract

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This research has been supported by a programme grant (14-358e) from the Dutch MS Research Foundation (Voorschoten, The Netherlands). The study in London was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3-6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T (p = 0.005). For patients, this was 4.18 and 4.40, respectively (p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training.

Published
2018
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35. Anisotropic flow in Xe-Xe collisions at root s(NN)=5.44 TeV

Author

ACHARYA, S, ACOSTA, FT, ADAMOVA, D, ADOLFSSON, J, AGGARWAL, MM, RINELLA, GA, AGNELLO, M, AGRAWAL, N, AHAMMED, Z, AHN, SU, AIOLA, S, AKINDINOV, A, AL-TURANY, M, ALAM, SN, ALBUQUERQUE, DSD, ALEKSANDROV, D, ALESSANDRO, B, MOLINA, RA, ALI, Y, ALICI, A, ALKIN, A, ALME, J, ALT, T, ALTENKAMPER, L, ALTSYBEEV, I, ANAAM, MN, ANDREI, C, ANDREOU, D, ANDREWS, HA, ANDRONIC, A, ANGELETTI, M, ANGUELOV, V, ANSON, C, ANTICIC, T, ANTINORI, F, ANTONIOLI, R, ANWAR, R, APADULA, N, APHECETCHE, L, APPELSHAUSER, H, ARCELLI, S, ARNALDI, R, ARNOLD, OW, ARSENE, IC, ARSLANDOK, M, AUDURIER, B, AUGUSTINUS, A, AVERBECK, R, AZMI, MD, BADALA, A, BAEK, YW, BAGNASCO, S, BAILHACHE, R, BALA, R, BALDISSERI, A, BALL, M, BARAL, RC, BARBANO, AM, BARBERA, R, BARILE, F, BARIOGLIO, L, BARNAFOLDI, GG, BARNBY, LS, BARRET, V, BARTALINI, R, BARTH, K, BARTSCH, E, BASTID, N, BASU, S, BATIGNE, G, BATYUNYA, B, BATZING, PC, ALBA, JLB, BEARDEN, IG, BECK, H, BEDDA, C, BEHERA, NK, BELIKOV, I, BELLINI, F, MARTINEZ, HB, BELLWIED, R, BELTRAN, LGE, BELYAEV, V, BENCEDI, G, BEOLE, S, BERCUCI, A, BERDNIKOV, Y, BERENYI, D, BERTENS, RA, BERZANO, D, BETEV, L, BHADURI, PP, BHASIN, A, BHAT, IR, BHATT, H, BHATTACHARJEE, B, BHOM, J, BIANCHI, A, BIANCHI, L, BIANCHI, N, BIELCIK, J, BIELCIKOVA, J, BILANDZIC, A, BIRO, G, BISWAS, R, BISWAS, S, BLAIR, JT, BLAU, D, BLUME, C, BOCA, G, BOCK, F, BOGDANOV, A, BOLDIZSAR, L, BOMBARA, M, BONOMI, G, BONORA, M, BORE, H, BORISSOV, A, BORRI, M, BOTTA, E, BOURJAU, C, BRATRUD, L, BRAUN-MUNZINGER, R, BREGANT, M, BROKER, TA, BROZ, M, BRUCKEN, EJ, BRUNA, E, BRUNO, GE, BUDNIKOV, D, BUESCHING, H, BUFALINO, S, BUHLERNL, R, BUNCIC, R, BUSCH, O, BUTHELEZI, Z, BUTT, JB, BUXTON, JT, CABALA, J, CAFFARRI, D, CAINES, H, CALIVA, A, VILLAR, EC, CAMACHO, RS, CAMERINI, R, CAPON, AA, CARENA, F, CARENA, W, CARNESECCHI, F, CASTELLANOS, JC, CASTRO, AJ, CASULA, EAR, SANCHEZ, CC, CHANDRA, S, CHANG, B, CHANG, W, CHAPELAND, S, CHARTIER, M, CHATTOPADHYAY, S, CHAUVIN, A, CHESHKOV, C, CHEYNIS, B, BARROSO, VC, CHINELLATO, DD, CHO, S, CHOCHULA, R, CHOWDHURY, T, CHRISTAKOGLOU, R, CHRISTENSEN, CH, CHRISTIANSEN, R, CHUJO, T, CHUNG, SU, CICALO, C, CIFARELLI, L, CINDOLO, F, CLEYMANS, J, COLAMARIA, F, COLELLA, D, CONTI, A, COLOCCI, M, CONCAS, M, BALBASTRE, GC, DEL VALLE, ZC, CONTRERAS, JG, CORMIER, TM, MORALES, YC, CORTESE, R, COSENTINO, MR, COSTA, F, COSTANZA, S, CRKOVSKA, J, CROCHET, R, CUAUTLE, E, CUNQUEIRO, L, DAHMS, T, DAINESE, A, DANI, S, DANISCH, MC, DANU, A, DAS, D, DAS, I, DAS, S, DASH, A, DASH, S, DE, S, DE CARO, A, DE CATALDO, G, DE CONTI, C, DE CUVELAND, J, DE FALCO, A, DE GRUTTOLA, D, DE MARCO, N, DE PASQUALE, S, DE SOUZA, RD, DEGENHARDT, HF, DEISTING, A, DELOFF, A, DELSANTO, S, DEPLANO, C, DHANKHER, R, DI BARI, D, DI MAURO, A, DI RUZZA, B, DIAZ, RA, DIETEL, T, DILLENSEGER, R, DING, Y, DIVIA, R, DJUVSLAND, O, DOBRIN, A, GIMENEZ, DD, DONIGUS, B, DORDIC, O, DOREMALEN, LVR, DUBEY, AK, DUBLA, A, DUCROUX, L, DUDI, S, DUGGAL, AK, DUKHISHYAM, M, DUPIEUX, R, EHLERS, RJ, ELIA, D, ENDRESS, E, ENGEL, H, EPPLE, E, ERAZMUS, B, ERHARDT, F, ERSDAL, MR, ESPAGNON, B, EULISSE, G, EUM, J, EVANS, D, EVDOKIMOV, S, FABBIETTI, L, FAGGIN, M, FAIVRE, J, FANTONI, A, FASEL, M, FELDKAMP, L, FELICIELLO, A, FEOFILOV, G, TELLEZ, AF, FERRETTI, A, FESTANTI, A, FEUILLARD, VJG, FIGIEL, J, FIGUEREDO, MAS, FILCHAGIN, S, FINOGEEV, D, FIONDA, FM, FIORENZA, G, FLOR, F, FLORIS, M, FOERTSCH, S, FOKA, R, FOKIN, S, FRAGIACOMO, E, FRANCESCON, A, FRANCISCO, A, FRANKENFELD, U, FRONZE, GG, FUCHS, U, FURGET, C, FURS, A, GIRARD, MF, GAARDHOJE, JJ, GAGLIARDI, M, GAGO, AM, GAJDOSOVA, K, GALLIO, M, GALVAN, CD, GANOTI, R, GARABATOS, C, GARCIA-SOLIS, E, GARG, K, GARGIULO, C, GASIK, R, GAUGER, EF, DUCATI, MBG, GERMAIN, M, GHOSH, J, GHOSH, R, GHOSH, SK, GIANOTTI, R, GIUBELLINOL, R, GIUBILATO, R, GLASSEL, R, CORAL, DMG, RAMIREZ, AG, GONZALEZ, V, GONZALEZ-ZAMORA, R, GORBUNOV, S, GORLICH, L, GOTOVAC, S, GRABSKI, V, GRACZYKOWSKI, LK, GRAHAM, KL, GREINER, L, GRELLI, A, GRIGORAS, C, GRIGORIEV, V, GRIGORYAN, A, GRIGORYAN, S, GRONEFELD, JM, GROSA, F, GROSSE-OETRINGHAUS, JF, GROSSO, R, GUERNANE, R, GUERZONI, B, GUITTIERE, M, GULBRANDSEN, K, GUNJI, T, GUPTA, A, GUPTA, R, GUZMAN, IB, HAAKE, R, HABIB, MK, HADJIDAKIS, C, HAMAGAKI, H, HAMAR, G, HAMID, M, HAMON, JC, HANNIGAN, R, HAGUE, MR, HARRIS, JW, HARTON, A, HASSAN, H, HATZIFOTIADOU, D, HAYASHI, S, HECKEL, ST, HELLBAR, E, HELSTRUP, H, HERGHELEGIU, A, HERNANDEZ, EG, CORRAL, GH, HERRMANN, F, HETLAND, KF, HILDEN, TE, HILLEMANNS, H, HILLS, C, HIPPOLYTE, B, HOHLWEGER, B, HORAK, D, HORNUNG, S, HOSOKAWA, R, HOTA, J, HRISTOV, R, HUANG, C, HUGHES, C, HUHN, R, HUMANIC, TJ, HUSHNUD, H, HUSSAIN, N, HUSSAIN, T, HUTTER, D, HWANG, DS, IDDON, JP, BUITRON, SAI, ILKAEV, R, INABAN, M, IPPOLITOV, M, ISLAM, MS, IVANOV, M, IVANOV, V, IZUCHEEV, V, JACAK, B, JACAZIO, N, JACOBS, PM, JADHAV, MB, JADLOVSKA, S, JADLOVSKY, J, JAELANI, S, JAHNKE, C, JAKUBOWSKA, MJ, JANIK, MA, JENA, C, JERCIC, M, JEVONS, O, BUSTAMANTE, RTJ, JIN, M, JONES, PG, JUSKO, A, KALINAK, R, KALWEIT, A, KANG, JH, KAPLIN, V, KAR, S, UYSAL, 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Subjects
ELLIPTIC FLOW, COLLECTIVE FLOW, NUCLEAR COLLISIONS, COLLABORATION
Abstract

The first measurements of anisotropic flow coefficients v(n) for mid-rapidity charged particles in Xe-Xe collisions at root s(NN)=5.44TeV are presented. Comparing these measurements to those from Pb-Pb collisions at root s(NN)=5.02 TeV, v(2) is found to be suppressed for mid-central collisions at the same centrality, and enhanced for central collisions. The values of v(3) are generally larger in Xe-Xe than in Pb-Pb at a given centrality. These observations are consistent with expectations from hydrodynamic predictions. When both v(2) and v(3) are divided by their corresponding eccentricities for a variety of initial state models, they generally scale with transverse density when comparing Xe-Xe and Pb-Pb, with some deviations observed in central Xe-Xe and Pb-Pb collisions. These results assist in placing strong constraints on both the initial state geometry and medium response for relativistic heavy-ion collisions. (c) 2018 European Organization for Nuclear Research. Published by Elsevier B.V.

Published
2018

36. Azimuthally-differential pion femtoscopy relative to the third harmonic event plane in Pb-Pbcollisions at root(NN)-N-S=2.76TeV

Author

ACHARYA, S, ACOSTA, FT, ADAMOVA, D, ADOLFSSON, J, AGGARWAL, MM, RINELLA, GA, AGNELLO, M, AGRAWAL, N, AHAMMED, Z, AHN, SU, AIOLA, S, AKINDINOV, A, AL-TURANY, M, ALAM, SN, ALBUQUERQUE, DSD, ALEKSANDROV, D, ALESSANDRO, B, MOLINA, RA, ALI, Y, ALICI, A, ALKIN, A, ALME, J, ALT, T, ALTENKAMPER, L, ALTSYBEEV, I, ANDREI, C, ANDREOU, D, ANDREWS, HA, ANDRONIC, A, ANGELETTI, M, ANGUELOV, V, ANSON, C, ANTICIC, T, ANTINORI, F, ANTONIOLI, P, APADULA, N, APHECETCHE, L, APPELSHAUSER, H, ARCELLI, S, ARNALDI, R, ARNOLD, OW, ARSENE, IC, ARSLANDOK, M, AUDURIER, B, AUGUSTINUS, A, AVERBECK, R, AZMI, MD, BADALA, A, BAEK, YW, BAGNASCO, S, BAILHACHE, R, BALA, R, BALDISSERI, A, BALL, M, BARAL, RC, BARBANO, AM, BARBERA, R, BARILE, F, BARIOGLIO, L, BARNAFOLDI, GG, BARNBY, LS, BARRET, V, BARTALINI, P, BARTH, K, BARTSCH, E, BASTID, N, BASU, S, BATIGNE, G, BATYUNYA, B, BATZING, PC, ALBA, LB, BEARDEN, IG, BECK, H, BEDDA, C, BEHERA, NK, BELIKOV, I, BELLINI, F, MARTINEZ, HB, BELLWIED, R, BELTRAN, LGE, BELYAEV, V, 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Subjects
INTERFEROMETRY, HEAVY-ION COLLISIONS, ANNIHILATION, ANISOTROPIC TRANSVERSE FLOW
Abstract

Azimuthally-differential femtoscopic measurements, being sensitive to spatio-temporal characteristics of the source as well as to the collective velocity fields at freeze out, provide very important information on the nature and dynamics of the system evolution. While the HBT radii oscillations relative to the second harmonic event plane measured recently reflect mostly the spatial geometry of the source, model studies have shown that the HBT radii oscillations relative to the third harmonic event plane are predominantly defined by the velocity fields. In this Letter, we present the first results on azimuthally-differential pion femtoscopy relative to the third harmonic event plane as a function of the pion pair transverse momentum k(T) for different collision centralities in Pb-Pb collisions at root(NN)-N-S = 2.76TeV. We find that the R-side and R-out radii, which characterize the pion source size in the directions perpendicular and parallel to the pion transverse momentum, oscillate in phase relative to the third harmonic event plane, similar to the results from 3+1D hydrodynamical calculations. The observed radii oscillations unambiguously signal a collective expansion and anisotropy in the velocity fields. A comparison of the measured radii oscillations with the Blast-Wave model calculations indicate that the initial state triangularity is washedout at freeze out. (C) 2018 European Organization for Nuclear Research. Published by Elsevier B.V.

Published
2018

37. Longitudinal asymmetry and its effect on pseudorapidity distributions in Pb-Pb collisions at root s(NN)=2.76 TeV

Author

ACHARYA, S, ADAM, J, ADAMOVA, D, ADOLFSSON, J, AGGARWAL, MM, RINELLA, GA, AGNELLO, M, AGRAWAL, N, AHAMMED, Z, AHMAD, N, AHN, SU, AIOLA, S, AKINDINOV, A, AL-TURANY, M, ALAM, SN, ALBA, JLB, ALBUQUERQUE, DSD, ALEKSANDROV, D, ALESSANDRO, B, MOLINA, RA, ALICI, A, ALKIN, A, ALME, J, ALT, T, ALTENKAMPER, L, ALTSYBEEV, I, PRADO, CAG, ANDREI, C, ANDREOU, D, ANDREWS, HA, ANDRONIC, A, ANGUELOV, V, ANSON, C, ANTICIC, T, ANTINORI, F, ANTONIOLI, R, ANWAR, R, APHECETCHE, L, APPELSHAUSER, H, ARCELLI, S, ARNALDI, R, ARNOLD, OW, ARSENE, IC, ARSLANDOK, M, AUDURIER, B, AUGUSTINUS, A, AVERBECK, R, AZMI, MD, BADALA, A, BAEK, YW, BAGNASCO, S, BAILHACHE, R, BALA, R, BALDISSERI, A, BALL, M, BARAL, RC, BARBANO, AM, BARBERA, R, BARILE, F, BARIOGLIO, L, BARNAFOLDI, GG, BARNBY, LS, BARRET, V, BARTALINI, R, BARTH, K, BARTSCH, E, BASILE, M, BASTIDNI, N, BASU, S, BATIGNE, G, BATYUNYA, B, BATZING, R, BEARDEN, IG, BECK, H, BEDDA, C, BEHERA, NK, BELIKOV, I, BELLINI, F, MARTINEZ, HB, BELLWIED, R, BELTRAN, LGE, BELYAEV, 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DLD, KEI, M, KETZER, B, KHABANOVA, Z, KHAN, R, KHAN, SA, KHANZADEEV, A, KHARLOV, Y, KHATUN, A, KHUNTIA, A, KIELBOWICZ, MM, KILENG, B, KIM, B, KIM, D, KIM, DJ, KIM, H, KIM, JS, KIM, J, KIM, M, KIM, S, KIM, T, KIRSCH, S, KISE, I, KISELEV, S, KISIEL, A, KISS, G, KLAY, JL, KLEIN, C, KLEIN, J, KLEIN-BOSING, C, KLEWIN, S, KLUGE, A, KNICHEL, ML, KNOSPE, AG, KOBDAJ, C, KOFARAGO, M, KOHLER, MK, KOLLEGGER, T, KONDRATIEV, V, KONDRATYEVA, N, KONDRATYUK, E, KONEVSKIKH, A, KONYUSHIKHIN, M, KOPCIK, M, KOURL, M, KOUZINOPOULOS, C, KOVALENKO, O, KOVALENKO, V, KOWALSKI, M, MEETHALEVEEDU, GK, KRALIK, I, KRAVAKOVA, A, KREIS, L, KRIVDA, M, KRIZEK, F, KRYSHEN, E, KRZEWICKI, M, KUBERA, AM, KTKERA, V, KUHN, C, KUIJER, PG, KUMAR, A, KUMAR, J, KUMAR, L, KUMAR, S, KUNDU, S, KURASHVILI, R, KUREPIN, A, KUREPIN, AB, KURYAKIN, A, KUSHPI, S, KWEON, MJ, KWON, Y, POINTE, SL, ROCCA, R, FERNANDES, CL, LAI, YS, LAKOMOV, I, LANGOY, R, LAPIDUS, K, LARA, C, LARDEUX, A, LATTUCA, A, LAUDI, E, LAVICKA, R, LEA, R, LEARDINI, L, LEE, S, LEHAS, F, LEHNER, S, LEHRBACH, J, LEMMON, RC, LEND, V, LEOGRANDE, E, LEON, I, LEVAI, R, LI, X, LIEN, J, LIETAVA, R, LIM, B, LINDAL, S, LINDENSTRUTH, V, LINDSAY, SW, LIPPMANN, C, LISA, MA, LITICHEVSKYI, V, LLOPE, WJ, LODATO, DF, LOENNE, R, LOGINOV, V, LOIZIDES, C, LONCAR, R, LOPEZ, X, TORRES, EL, LOWE, A, LUETTIG, R, LUHDER, JR, LUNARDON, M, LUPARELLO, G, LUPI, M, LUTZ, TH, MAEVSKAYA, A, MAGER, M, MAHAJAN, S, MAHMOOD, SM, MAIRE, A, MAJKA, RD, MALAEV, M, MALININA, L, MAL'KEVICH, D, MALZACHER, R, MAMONOVMS, A, MANKO, V, MANS, F, MANZARI, V, MAO, Y, MARCHISONE, M, MARES, J, MARGAGLIOTTI, GV, MARGOTTI, A, MARGUTTI, J, MARIN, A, MARKERT, C, MARQUARD, M, MARTIN, NA, MARTINENGO, R, MARTINEZ, JAL, MARTINEZ, MI, GARCIA, GM, PEDREIRA, MM, MASCIOCCHIL, S, MASERA, M, MASONI, A, MASSON, E, MASTROSERIO, A, MATHIS, AM, MATUOKA, PFT, MATYJA, A, MAYER, C, MAZER, J, MAZZILLI, M, MAZZONI, MA, MEDDI, F, MELIKYAN, Y, MENCHACA-ROCHA, A, MENINNO, E, PEREZ, JM, MERES, M, MHLANGA, S, MIAKE, Y, MIESKOLAINEN, MM, MIHAYLOV, DL, MIKHAYLOV, K, MILOSEVIC, J, MISCHKE, A, MISHRA, AN, MISKOWIEC, D, MITRA, J, MITU, CM, MOHAMMADI, N, MOHANTY, B, KHAN, MM, GODOY, DAM, MORENO, LAP, MORETTO, S, MORREALE, A, MORSCH, A, MUCCIFORA, V, MUDNIC, E, MIIHLHEIM, D, MUHURI, S, MUKHERJEE, M, MULLIGAN, JD, MUNHOZ, MG, MUNNING, K, MUNZER, RH, MURAKAMI, H, MURRAY, S, MUSA, L, MUSINSKY, J, MYERS, CJ, MYRCHA, JW, NAG, D, NAIK, B, NAIR, R, NANDI, BK, NANIA, R, NAPPI, E, NARAYAN, A, NARU, MU, LUZ, HN, NATTRASS, C, NAVARRO, SR, NAYAK, K, NAYAK, R, NAYAK, TK, NAZARENKO, S, NEDOSEKIN, A, OLIVEIRA, RAN, NELLEN, L, NESBO, SV, NG, F, NICASSIO, M, NICULESCU, M, NIEDZIELA, J, NIELSEN, BS, NIKOLAEV, S, NIKULIN, S, NIKULIN, V, NOFERINI, F, NOMOKONOV, R, NOOREN, G, NORIS, JCC, NORMAN, J, NYANIN, A, NYSTRAND, J, OESCHLER, H, OH, S, OHLSON, A, OKUBO, T, OLAH, L, OLENIACZ, J, SILVA, ACO, OLIVER, MH, ONDERWAATER, J, OPPEDISANO, C, ORAVA, R, ORAVEC, M, VELASQUEZ, AO, OSKARSSON, A, OTWINOWSKI, J, OYAMA, K, PACHMAYER, Y, PACIK, V, PAGANO, D, PAGANO, R, PAIC, G, PALNI, R, PAN, J, PANDEY, AK, PANEBIANCO, S, PAPIKYAN, V, PAPPALARDO, GS, PAREEK, R, PARK, J, PARMAR, S, PASSFELD, A, PATHAK, SP, PATRA, RN, PAUL, B, PEI, H, PEITZMANN, T, PENG, X, PEREIRA, LG, COSTA, HP, PERESUNKO, D, LEZAMA, EP, PESKOV, V, PESTOV, Y, PETRACEK, V, PETROV, V, PETROVICI, M, PENA, C, PEZZI, RP, PIANO, S, PIKNA, M, PILLOT, R, PIMENTEL, LODL, PINAZZA, O, PINSKY, L, PIYARATHNA, DB, PLOSKON, M, PLANINIC, M, PLIQUETT, F, PLUTA, J, POCHYBOVA, S, PODESTA-LERMA, PLM, POGHOSYANG, MG, POLICHTCHOUK, B, POLJAK, N, POONSAWAT, W, POP, A, POPPENBORE, H, PORTEBOEUF-HOUSSAIS, S, POZDNIAKOV, V, PRASAD, SK, PREGHENELLA, R, PRINO, F, PRUNEAU, CA, PSHENICHNOV, I, PUCCIO, M, PUDDU, G, PUJAHARI, R, PUNIN, V, PUTSCHKE, J, RAHA, S, RAJPUT, S, RAK, J, RAKOTOZAFINDRABE, A, RAMELLO, L, RAMI, F, RANA, DB, RANIWALA, R, RANIWALA, S, RASANEN, SS, RASCANU, BT, RATHEE, D, RATZA, V, RAVASENGA, I, READ, KF, REDLICH, K, REHMAN, A, REICHELT, R, REIDT, F, REN, X, RENFORDT, R, REOLON, AR, RESHETIN, A, REYGERS, K, RIABOV, V, RICCI, RA, RICHERT, T, RICHTER, M, RIEDLER, R, RIEGLER, W, RIGGI, F, RISTEA, C, CAHUANTZI, MR, ROED, K, ROGOCHAYA, E, ROHR, D, ROHRICH, D, ROKITA, R, RONCHETTI, F, ROSAS, ED, ROSNET, R, ROSSI, A, ROTONDI, A, ROUKOUTAKIS, F, ROY, A, ROY, C, ROY, R, RUEDA, OV, RUI, R, RUMYANTSEV, B, RUSTAMOV, A, RYABINKIN, E, RYABOV, Y, RYBICKI, A, SAARINEN, S, SADHU, S, SADOVSKY, S, SAFARIK, K, SAHA, SK, SAHLMULLER, B, SAHOO, B, SAHOO, R, SAHOO, S, SAHU, PK, SAINI, J, SAKAI, S, SALEH, MA, SALZWEDE, J, SAMBYALM, S, SAMSONOV, V, SANDOVAL, A, SARKAR, D, SARKAR, N, SARMA, R, SAS, MHP, SCAPPARONE, E, SCARLASSARA, F, SCHAEFER, B, SCHARENBERG, RP, SCHEID, HS, SCHIAUA, C, SCHICKER, R, SCHMIDT, C, SCHMIDT, HR, SCHMIDT, MO, SCHMIDT, M, SCHMIDT, NV, SCHUKRAFT, J, SCHUTZ, Y, SCHWARZ, K, SCHWEDA, K, SCIOLI, G, SCOMPARIN, E, SEFCIK, M, SEGER, JE, SEKIGUCHI, Y, SEKIHATA, D, SELYUZHENKOV, I, SENOSI, K, SENYUKOV, S, SERRADILLA, E, SETT, R, SEVCENCO, A, SHABANOV, A, SHABETAI, A, SHAHOYAN, R, SHAIKH, W, SHANGARAEV, A, SHARMA, A, SHARMA, M, SHARMA, N, SHEIKH, AI, SHIGAKI, K, SHOU, Q, SHTEJER, K, SIBIRIAK, Y, SIDDHANTA, S, SIELEWICZ, KM, SIEMIARCZUK, T, SILAEVA, S, SILVERMYR, D, SILVESTRE, C, SIMATOVIC, G, SIMONETTI, G, SINGARAJU, R, SINGH, R, SINGHAL, V, SINHA, T, SITAR, B, SITTA, M, SKAALI, TB, SLUPECKI, M, SMIRNOV, N, SNELLINGS, RJM, SNELLMAN, TW, SONG, J, SONG, M, SORAME, F, SORENSEN, S, SOZZI, F, SPIRITI, E, SPUTOWSKA, I, SRIVASTAVA, BK, STACHEL, J, STAN, I, STANKUS, P, STENLUND, E, STOCCO, D, STORETVEDT, MM, STRMEN, R, SUAIDE, AAP, SUGITATE, T, SUIRE, C, SULEYMANOV, M, STLIJIC, M, SULTANOV, R, SUMBERA, M, SUMOWIDAGDO, S, SUZUKI, K, SWAIN, S, SZABO, A, SZARKA, I, TABASSAM, U, TAKAHASHI, J, TAMBAVE, GJ, TANAKA, N, TARHINI, M, TARIQ, M, TARZILA, MG, TAURO, A, MUNOZ, GT, TELESCA, A, TERASAKI, K, TERREVOLI, C, TEYSSIER, B, THAKUR, D, THAKUR, S, THOMAS, D, THORESEN, F, TIEULENT, R, TIKHONOV, A, TIMMINS, AR, TOIA, A, TORRES, SR, TRIPATHY, S, TROGOLO, S, TROMBETTA, G, TROPP, L, TRUBNIKOV, V, TRZASKA, WH, TRZECIAK, BA, TSUJI, T, TUMKIN, A, TURRISI, R, TVETER, TS, ULLALAND, K, UMAKA, EN, URAS, A, USAI, GL, UTROBICIC, A, VALA, M, MAARE, JJD, HOORNE, JW, LEEUWEN, M, VANAT, T, VYVRE, RV, VARGA, D, VARGAS, A, VARGYAS, M, VARMA, R, VASILEIOU, M, VASILIEV, A, VAUTHIER, A, DOCE, OV, VECHERNIN, V, VEEN, AM, VELURE, A, VERCELLIN, E, LIMON, SV, VERNET, R, VERTESI, R, VICKOVIC, L, VIGOLO, S, VIINIKAINEN, J, VILAKAZI, Z, BAILLIE, OV, TELLO, AV, VINOGRADOV, A, VINOGRADOV, L, VIRGILI, T, VISLAVICIUS, V, VODOPYANOV, A, VOLKL, MA, VOLOSHIN, K, VOLOSHIN, SA, VOLPE, G, HALLER, B, VOROBYEV, I, VOSCEK, D, VRANIC, D, VRLAKOVA, J, WAGNER, B, WANG, H, WANG, M, WATANABE, D, WATANABE, Y, WEBER, M, WEBER, SG, WEISER, DF, WENZEL, SC, WESSELS, JP, WESTERHOFF, U, WHITEHEAD, AM, WIECHULA, J, WIKNE, J, WILK, G, WILKINSON, J, WILLEMS, GA, WILLIAMS, MCS, WILLSHER, E, WINDELBAND, B, WITT, WE, YALCIN, S, YAMAKAWA, K, YANG, R, YANO, S, YIN, Z, YOKOYAMA, H, YOO, IK, YOON, JH, YURCHENKO, V, ZACCOLO, V, ZAMAN, A, ZAMPOLLI, C, ZANOLI, HJC, ZARDOSHTI, N, ZAROCHENTSEV, A, ZAVADA, R, ZAVIYALOV, N, ZBROSZCZYK, H, ZHALOV, M, ZHANG, H, ZHANG, X, ZHANG, Y, and ZHANG, C

Subjects
DENSITY, CENTRALITY DEPENDENCE
Abstract

First results on the longitudinal asymmetry and its effect on the pseudorapidity distributions in Pb-Pb collisions at root s(NN) = 2.76 TeV at the Large Hadron Collider are obtained with the ALICE detector. The longitudinal asymmetry arises because of an unequal number of participating nucleons from the two colliding nuclei, and is estimated for each event by measuring the energy in the forward neutron-Zero-Degree-Calorimeters (ZNs). The effect of the longitudinal asymmetry is measured on the pseudorapidity distributions of charged particles in the regions vertical bar eta vertical bar < 0.9, 2.8 < eta < 5.1 and -3.7 < eta < -1.7 by taking the ratio of the pseudorapidity distributions from events corresponding to different regions of asymmetry. The coefficients of a polynomial fit to the ratio characterise the effect of the asymmetry. A Monte Carlo simulation using a Glauber model for the colliding nuclei is tuned to reproduce the spectrum in the ZNs and provides a relation between the measurable longitudinal asymmetry and the shift in the rapidity (y(0)) of the participant zone formed by the unequal number of participating nucleons. The dependence of the coefficient of the linear term in the polynomial expansion, c(1), on the mean value of y(0) is investigated. (C) 2018 The Author(s). Published by Elsevier B.V.

Published
2018

40. Novel human anti-Claudin 1 monoclonal antibodies inhibit HCV infection and may synergize with anti-SRB1 mAb

Author

PACIELLO, ROLANDO, Urbanowicz, Ra, Riccio, G, SASSO, EMANUELE, Mcclure, Pc, ZAMBRANO, NICOLA, Ball, Jk, Cortese, R, NICOSIA, Alfredo, DE LORENZO, CLAUDIA, Paciello, Rolando, Urbanowicz, Ra, Riccio, G, Sasso, Emanuele, Mcclure, Pc, Zambrano, Nicola, Ball, Jk, Cortese, R, Nicosia, Alfredo, and DE LORENZO, Claudia

Abstract

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver carcinoma and new therapies based on novel targets are needed. The tight junction protein Claudin 1 (CLDN-1) is essential for hepatitis C virus (HCV) cell entry and spread and anti-CLDN-1 rat and mouse monoclonal antibodies are safe and effective in preventing and treating HCV infection in a human liver chimeric mouse model. To accelerate translation of these observations into a novel approach to treat HCV infection and disease in humans, we screened a phage display library of human single chain antibody fragments (scFv) by using a panel of CLDN-1-positive and -negative cell lines and identified phage specifically binding to CLDN-1. Twelve clones, showing the highest levels of binding, were converted into human IgG4. Some of these mAbs display low nanomolar affinity, and inhibit infection of human hepatoma HuH7.5 cells by different HCV isolates in a dose-dependent manner. Cross-competition experiments identified six inhibitory mAbs that recognized distinct epitopes. Combination of the human anti-SRB1 mAb C-1671 with these anti-CLDN-1 mAbs could either increase or reduce inhibition of HCVcc infection in vitro. These novel human anti-CLDN-1 mAbs are potentially useful to develop a new strategy for anti-HCV therapy and lend support to the combined use of antibodies targeting the HCV receptors CLDN-1 and SRB1, but indicate that care must be taken in selecting the proper combination.

Published
2016

41. Chronic Hepatitis C Virus infection subverts vaccine induced T-cell immunity in humans

Author

Kelly, C, Swadling, L, Capone, S, Brown, A, Richardson, R, Halliday, J, von Delft, A, Oo, Y, Mutimer, D, Kurioka, A, Hartnell, F, Collier, J, Ammendola, V, Del Sorbo, M, Grazioli, F, Luisa Esposito, M, Di Marco, S, Siani, L, Traboni, C, Hill, A, Colloca, S, Nicosia, A, Cortese, R, Folgori, A, Klenerman, P, Barnes, E, Kelly, C, Swadling, L, Capone, S, Brown, A, Richardson, R, Halliday, J, von Delft, A, Oo, Y, Mutimer, D, Kurioka, A, Hartnell, F, Collier, J, Ammendola, V, Del Sorbo, M, Grazioli, F, Esposito, Ml, Di Marco, S, Siani, L, Traboni, C, Hill, Av, Colloca, S, Nicosia, A, Cortese, R, Folgori, A, Klenerman, P, and Barnes, E

Abstract

Adenoviral vectors encoding hepatitis C virus (HCV) nonstructural (NS) proteins induce multispecific, high-magnitude, durable CD4(+) and CD8(+) T-cell responses in healthy volunteers. We assessed the capacity of these vaccines to induce functional HCV-specific immune responses and determine T-cell cross-reactivity to endogenous virus in patients with chronic HCV infection. HCV genotype 1-infected patients were vaccinated using heterologous adenoviral vectors (ChAd3-NSmut and Ad6-NSmut) encoding HCV NS proteins in a dose escalation, prime-boost regimen, with and without concomitant pegylated interferon-α/ribavirin therapy. Analysis of immune responses ex vivo used human leukocyte antigen class I pentamers, intracellular cytokine staining, and fine mapping in interferon-γ enzyme-linked immunospot assays. Cross-reactivity of T cells with population and endogenous viral variants was determined following viral sequence analysis. Compared to healthy volunteers, the magnitude of HCV-specific T-cell responses following vaccination was markedly reduced. CD8(+) HCV-specific T-cell responses were detected in 15/24 patients at the highest dose, whereas CD4(+) T-cell responses were rarely detectable. Analysis of the host circulating viral sequence showed that T-cell responses were rarely elicited when there was sequence homology between vaccine immunogen and endogenous virus. In contrast, T cells were induced in the context of genetic mismatch between vaccine immunogen and endogenous virus; however, these commonly failed to recognize circulating epitope variants and had a distinct partially functional phenotype. Vaccination was well tolerated but had no significant effect on HCV viral load. CONCLUSION: Vaccination with potent HCV adenoviral vectored vaccines fails to restore T-cell immunity except where there is genetic mismatch between vaccine immunogen and endogenous virus; this highlights the major challenge of overcoming T-cell exhaustion in the context of persistent antigen exposure with implications for cancer and other persistent infections.

Published
2016

42. Gender Inequities in the Multiple Sclerosis Community: A Call for Action

Author

Waubant, E, Amezcua, L, Sicotte, N, Hellwig, K, Krupp, L, Weinstock-Guttman, B, Yeh, A, Lucas, RM, Longbrake, EE, Yadav, V, Rensel, M, Mar, S, Hersh, C, Block, V, Zipp, F, Han, MH, Spain, R, Kelland, EE, Charvet, L, Dimitri, D, Papeix, C, Cross, AH, Inglese, M, Amato, MP, Airas, L, Leray, E, Sormani, MP, Van der Walt, A, Vukusic, S, Castillo-Trivino, T, Tenembaum, S, Ciccarelli, O, Bommarito, G, Petracca, M, Celius, EG, Carson, MJ, Hua, LH, Van der Mei, I, Lubetzki, C, Jokubaitis, V, Trojano, M, Voskuhl, R, Tintore, M, Harbo, H, Asgari, N, Piccio, L, Burton, JM, Tremlett, H, Goldman, MD, Michel, L, Zhang, Y, Bove, R, Quandt, JA, Costello, F, Ionete, C, Lebrun-Frenay, C, Pakpoor, J, Bevan, C, Morrow, SA, Waldman, AT, Oh, J, Jacobs, D, Palace, J, Marrie, RA, Tiwari-Woodruff, SK, Metz, LM, Cortese, R, Chitnis, T, Benson, L, Benveniste, ET, Conway, J, Sand, IK, Murphy, JO, Kita, M, Riley, C, Goverman, JM, Langer-Gould, AM, Azevedo, CJ, Morales, IB, Barcellos, LF, Crabtree, E, Plummer, P, Shirani, A, Whartenby, K, Brilot-Turville, F, Kingwell, E, Coyle, P, Mowry, E, Zabad, R, Bielekova, B, Monson, N, Laule, C, Burnett, M, Schreiner, T, Grinspan, J, Dobson, R, Akassoglou, K, Graves, J, Gray, O, Smyth, P, Havrdova, EK, Preiningerova, JL, Banwell, B, Makhani, N, Lucchinetti, C, Arrambide, G, Maillart, E, Macklin, W, Gilmore, W, Waubant, E, Amezcua, L, Sicotte, N, Hellwig, K, Krupp, L, Weinstock-Guttman, B, Yeh, A, Lucas, RM, Longbrake, EE, Yadav, V, Rensel, M, Mar, S, Hersh, C, Block, V, Zipp, F, Han, MH, Spain, R, Kelland, EE, Charvet, L, Dimitri, D, Papeix, C, Cross, AH, Inglese, M, Amato, MP, Airas, L, Leray, E, Sormani, MP, Van der Walt, A, Vukusic, S, Castillo-Trivino, T, Tenembaum, S, Ciccarelli, O, Bommarito, G, Petracca, M, Celius, EG, Carson, MJ, Hua, LH, Van der Mei, I, Lubetzki, C, Jokubaitis, V, Trojano, M, Voskuhl, R, Tintore, M, Harbo, H, Asgari, N, Piccio, L, Burton, JM, Tremlett, H, Goldman, MD, Michel, L, Zhang, Y, Bove, R, Quandt, JA, Costello, F, Ionete, C, Lebrun-Frenay, C, Pakpoor, J, Bevan, C, Morrow, SA, Waldman, AT, Oh, J, Jacobs, D, Palace, J, Marrie, RA, Tiwari-Woodruff, SK, Metz, LM, Cortese, R, Chitnis, T, Benson, L, Benveniste, ET, Conway, J, Sand, IK, Murphy, JO, Kita, M, Riley, C, Goverman, JM, Langer-Gould, AM, Azevedo, CJ, Morales, IB, Barcellos, LF, Crabtree, E, Plummer, P, Shirani, A, Whartenby, K, Brilot-Turville, F, Kingwell, E, Coyle, P, Mowry, E, Zabad, R, Bielekova, B, Monson, N, Laule, C, Burnett, M, Schreiner, T, Grinspan, J, Dobson, R, Akassoglou, K, Graves, J, Gray, O, Smyth, P, Havrdova, EK, Preiningerova, JL, Banwell, B, Makhani, N, Lucchinetti, C, Arrambide, G, Maillart, E, Macklin, W, and Gilmore, W

Published
2018

43. ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

Author

Sheehy, SH, Duncan, CJ, Elias, SC, Choudhary, P, Biswas, S, Halstead, FD, Collins, KA, Edwards, NJ, Douglas, AD, Anagnostou, NA, Ewer, KJ, Havelock, T, Mahungu, T, Bliss, CM, Miura, K, Poulton, ID, Lillie, PJ, Antrobus, RD, Berrie, E, Moyle, S, Gantlett, K, Colloca, S, Cortese, R, Long, CA, Sinden, RE, Gilbert, SC, Lawrie, AM, Doherty, T, Faust, SN, Nicosia, A, Hill, AV, Draper, SJ, Sheehy, Sh, Duncan, Cj, Elias, Sc, Choudhary, P, Biswas, S, Halstead, Fd, Collins, Ka, Edwards, Nj, Douglas, Ad, Anagnostou, Na, Ewer, Kj, Havelock, T, Mahungu, T, Bliss, Cm, Miura, K, Poulton, Id, Lillie, Pj, Antrobus, Rd, Berrie, E, Moyle, S, Gantlett, K, Colloca, S, Cortese, R, Long, Ca, Sinden, Re, Gilbert, Sc, Lawrie, Am, Doherty, T, Faust, Sn, Nicosia, Alfredo, Hill, Av, and Draper, Sj

Subjects
Pharmacology, MEROZOITE SURFACE PROTEIN-1, PLASMODIUM-FALCIPARUM, POLYMERASE-CHAIN-REACTION, IMMUNE-RESPONSES, IN-VITRO, PARASITE GROWTH, ANTIBODY, parasitic diseases, Drug Discovery, T-CELLS, Genetics, Molecular Medicine, PROTECTION, APICAL MEMBRANE ANTIGEN-1, Molecular Biology
Abstract

The induction of cellular immunity, in conjunction with antibodies, may be essential for vaccines to protect against blood-stage infection with the human malaria parasite Plasmodium falciparum. We have shown that prime-boost delivery of P. falciparum blood-stage antigens by chimpanzee adenovirus 63 (ChAd63) followed by the attenuated orthopoxvirus MVA is safe and immunogenic in healthy adults. Here, we report on vaccine efficacy against controlled human malaria infection delivered by mosquito bites. The blood-stage malaria vaccines were administered alone, or together (MSP1+AMA1), or with a pre-erythrocytic malaria vaccine candidate (MSP1+ME-TRAP). In this first human use of coadministered ChAd63-MVA regimes, we demonstrate immune interference whereby responses against merozoite surface protein 1 (MSP1) are dominant over apical membrane antigen 1 (AMA1) and ME-TRAP. We also show that induction of strong cellular immunity against MSP1 and AMA1 is safe, but does not impact on parasite growth rates in the blood. In a subset of vaccinated volunteers, a delay in time to diagnosis was observed and sterilizing protection was observed in one volunteer coimmunized with MSP1+AMA1-results consistent with vaccine-induced pre-erythrocytic, rather than blood-stage, immunity. These data call into question the utility of T cell-inducing blood-stage malaria vaccines and suggest that the focus should remain on high-titer antibody induction against susceptible antigen targets.

Published
2012
Full Text
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44. Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans

Author

Kelly, C, Swadling, L, Capone, S, Brown, A, Richardson, R, Halliday, J, von Delft, A, Oo, Y, Mutimer, D, Kurioka, A, Hartnell, F, Collier, J, Ammendola, V, Sorbo, MD, Grazioli, F, Esposito, ML, Marco, SD, Siani, L, Traboni, C, Hill, A, Colloca, S, Nicosia, A, Cortese, R, Folgori, A, Klenerman, P, and Barnes, E

Abstract

Adenoviral vectors encoding hepatitis C virus (HCV) nonstructural (NS) proteins induce multispecific, high-magnitude, durable CD4+ and CD8+ T-cell responses in healthy volunteers. We assessed the capacity of these vaccines to induce functional HCV-specific immune responses and determine T-cell cross-reactivity to endogenous virus in patients with chronic HCV infection. HCV genotype 1-infected patients were vaccinated using heterologous adenoviral vectors (ChAd3-NSmut and Ad6-NSmut) encoding HCV NS proteins in a dose escalation, prime-boost regimen, with and without concomitant pegylated interferon-α/ribavirin therapy. Analysis of immune responses ex vivo used human leukocyte antigen class I pentamers, intracellular cytokine staining, and fine mapping in interferon-γ enzyme-linked immunospot assays. Cross-reactivity of T cells with population and endogenous viral variants was determined following viral sequence analysis. Compared to healthy volunteers, the magnitude of HCV-specific T-cell responses following vaccination was markedly reduced. CD8+ HCV-specific T-cell responses were detected in 15/24 patients at the highest dose, whereas CD4+ T-cell responses were rarely detectable. Analysis of the host circulating viral sequence showed that T-cell responses were rarely elicited when there was sequence homology between vaccine immunogen and endogenous virus. In contrast, T cells were induced in the context of genetic mismatch between vaccine immunogen and endogenous virus; however, these commonly failed to recognize circulating epitope variants and had a distinct partially functional phenotype. Vaccination was well tolerated but had no significant effect on HCV viral load. Conclusion: Vaccination with potent HCV adenoviral vectored vaccines fails to restore T-cell immunity except where there is genetic mismatch between vaccine immunogen and endogenous virus; this highlights the major challenge of overcoming T-cell exhaustion in the context of persistent antigen exposure with implications for cancer and other persistent infections.

Published
2017

45. Abstracts of the Eighth EDCTP Forum, 6-9 November 2016.

Author

Makanga, M, Beattie, P, Breugelmans, G, Nyirenda, T, Bockarie, M, Tanner, M, Volmink, J, Hankins, C, Walzl, G, Chegou, N, Malherbe, S, Hatherill, M, Scriba, TJ, Zak, DE, Barry, CE, Kaufmann, SHE, Noor, A, Strub-Wourgaft, N, Phillips, P, Munguambe, K, Ravinetto, R, Tinto, H, Diro, E, Mahendrahata, Y, Okebe, J, Rijal, S, Garcia, C, Sundar, S, Ndayisaba, G, Sopheak, T, Ngoduc, T, Van Loen, H, Jacobs, J, D'Alessandro, U, Boelaert, M, Buvé, A, Kamalo, P, Manda-Taylor, L, Rennie, S, Mokgatla, B, Bahati, Ijsselmuiden, C, Afolabi, M, Mcgrath, N, Kampmann, B, Imoukhuede, E, Alexander, N, Larson, H, Chandramohan, D, Bojang, K, Kasaro, MP, Muluka, B, Kaunda, K, Morse, J, Westfall, A, Kapata, N, Kruuner, A, Henostroza, G, Reid, S, Alabi, A, Foguim, F, Sankarganesh, J, Bruske, E, Mfoumbi, A, Mevyann, C, Adegnika, A, Lell, B, Kranzer, K, Kremsner, P, Grobusch, M, Sabiiti, W, Ntinginya, N, Kuchaka, D, Azam, K, Kampira, E, Mtafya, B, Bowness, R, Bhatt, N, Davies, G, Kibiki, G, Gillespie, S, Lejon, V, Ilboudo, H, Mumba, D, Camara, M, Kaba, D, Lumbala, C, Fèvre, E, Jamonneau, V, Bucheton, B, Büscher, P, Chisenga, C, Sinkala, E, Chilengi, R, Chitundu, H, Zyambo, Z, Wandeler, G, Vinikoor, M, Emilie, D, Camara, O, Mathurin, K, Guiguigbaza-Kossigan, D, Philippe, B, Regassa, F, Hassane, S, Bienvenu, SM, Fabrice, C, Ouédraogo, E, Kouakou, L, Owusu, M, Mensah, E, Enimil, A, Mutocheluh, M, Ndongo, FA, Tejiokem, MC, Texier, G, Penda, C, Ndiang, S, Ndongo, J-A, Guemkam, G, Sofeu, CL, Afumbom, K, Faye, A, Msellati, P, Warszawski, J, Vos, A, Devillé, W, Barth, R, Klipstein-Grobusch, K, Tempelman, H, Venter, F, Coutinho, R, Grobbee, D, Ssemwanga, D, Lyagoba, F, Magambo, B, Kapaata, A, Kirangwa, J, Nannyonjo, M, Nassolo, F, Nsubuga, R, Yebra, G, Brown, A, Kaleebu, P, Nylén, H, Habtewold, A, Makonnen, E, Yimer, G, Burhenne, J, Diczfalusy, U, Aklillu, E, Steele, D, Walker, R, Simuyandi, M, Beres, L, Bosomprah, S, Ansumana, R, Taitt, C, Lamin, JM, Jacobsen, KH, Mulvaney, SP, Leski, T, Bangura, U, Stenger, D, De Vries, S, Zinsou, FJ, Honkpehedji, J, Dejon, JC, Loembe, MM, Bache, B, Pakker, N, Van Leeuwen, R, Hounkpatin, AB, Yazdanbakhsh, M, Bethony, J, Hotez, P, Diemert, D, Bache, BE, Fernandes, JF, Obiang, RM, Kabwende, AL, Grobusch, MP, Krishna, S, Kremsner, PG, Todagbe, AS, Nambozi, M, Kabuya, J-B, Hachizovu, S, Mwakazanga, D, Kasongo, W, Buyze, J, Mulenga, M, Geertruyden, J-P, Gitaka, J, Chan, C, Kongere, J, Kagaya, W, Kaneko, A, Kabore, N, Barry, N, Kabre, Z, Werme, K, Fofana, A, Compaore, D, Nikiema, F, Some, F, Djimde, A, Zongo, I, Ouedraogo, B, Kone, A, Sagara, I, Björkman, A, Gil, JP, Nchinda, G, Bopda, A, Nji, N, Ambada, G, Ngu, L, Tchadji, J, Sake, C, Magagoum, S, Njambe, GD, Lisom, A, Park, CG, Tait, D, Sibusiso, H, Manda, O, Croucher, K, Van Der Westhuizen, A, Mshanga, I, Levin, J, Nanvubya, A, Kibengo, F, Jaoko, W, Pala, P, Perreau, M, Namuniina, A, Kitandwe, P, Tapia, G, Serwanga, J, Yates, N, Fast, P, Mayer, B, Montefiori, D, Tomaras, G, Robb, M, Lee, C, Wagner, R, Sanders, E, Kilembe, W, Kiwanuka, N, Gilmour, J, Kuipers, H, Vooij, D, Chinyenze, K, Priddy, F, Ding, S, Hanke, T, Pantaleo, G, Ngasala, B, Jovel, I, Malmberg, M, Mmbando, B, Premji, Z, Mårtensson, A, Mwaiswelo, R, Agbor, L, Apinjoh, T, Mwanza, S, Chileshe, J, Joshi, S, Malunga, P, Manyando, C, Laufer, M, Dara, A, Niangaly, A, Sinha, I, Brodin, D, Fofana, B, Dama, S, Dembele, D, Sidibe, B, Diallo, N, Thera, M, Wright, K, Gil, J, Doumbo, O, Baraka, V, Nabasumba, C, Francis, F, Lutumba, P, Mavoko, H, Alifrangis, M, Van Geertruyden, J-P, Sissoko, S, Sangaré, C, Toure, S, Sanogo, K, Diakite, H, Doumbia, D, Haidara, K, Julé, A, Ashurst, H, Merson, L, Olliaro, P, Marsh, V, Lang, T, Guérin, P, Awuondo, K, Njenga, D, Nyakarungu, E, Titus, P, Sutamihardja, A, Lowe, B, Ogutu, B, Billingsley, P, Soulama, I, Kaboré, M, Coulibaly, A, Ouattara, M, Sanon, S, Diarra, A, Bougouma, E, Ouedraogo, A, Sombie, B, Kargougou, D, Ouattara, D, Issa, N, Tiono, A, Sirima, S, Chaponda, M, Dabira, E, Dao, F, Dara, N, Coulibaly, M, Tolo, A, Maiga, H, Ouologuem, N, Niangaly, H, Botchway, F, Wilson, N, Dickinson-Copeland, CM, Adjei, AA, Wilson, M, Stiles, JK, Hamid, MA, Awad-Elgeid, M, Nasr, A, Netongo, P, Kamdem, S, Velavan, T, Lasry, E, Diarra, M, Bamadio, A, Traore, A, Coumare, S, Soma, B, Dicko, Y, Sangare, B, Tembely, A, Traore, D, Haidara, A, Dicko, A, Diawara, E, Beavogui, A, Camara, D, Sylla, M, Yattara, M, Sow, A, Camara, GC, Diallo, S, Mombo-Ngoma, G, Remppis, J, Sievers, M, Manego, RZ, Endamne, L, Hutchinson, D, Held, J, Supan, C, Salazar, CLO, Bonkian, LN, Nahum, A, Sié, A, Abdulla, S, Cantalloube, C, Djeriou, E, Bouyou-Akotet, M, Mordmüller, B, Siribie, M, Sirima, SB, Ouattara, SM, Coulibaly, S, Kabore, JM, Amidou, D, Tekete, M, Traore, O, Haefeli, W, Borrmann, S, Kaboré, N, Kabré, Z, Nikèma, F, Compaoré, D, Somé, F, Djimdé, A, Ouédraogo, J, Chalwe, V, Miller, J, Diakité, H, Greco, B, Spangenberg, T, Kourany-Lefoll, E, Oeuvray, C, Mulry, J, Tyagarajan, K, Magsaam, B, Barnes, K, Hodel, EM, Humphreys, G, Pace, C, Banda, CG, Denti, P, Allen, E, Lalloo, D, Mwapasa, V, Terlouw, A, Mwesigwa, J, Achan, J, Jawara, M, Ditanna, G, Worwui, A, Affara, M, Koukouikila-Koussounda, F, Kombo, M, Vouvoungui, C, Ntoumi, F, Etoka-Beka, MK, Deibert, J, Poulain, P, Kobawila, S, Gueye, NG, Seda, B, Kwambai, T, Jangu, P, Samuels, A, Kuile, FT, Kariuki, S, Barry, A, Bousema, T, Okech, B, Egwang, T, Corran, P, Riley, E, Ezennia, I, Ekwunife, O, Muleba, M, Stevenson, J, Mbata, K, Coetzee, M, Norris, D, Moneke-Anyanwoke, N, Momodou, J, Clarke, E, Scott, S, Tijani, A, Djimde, M, Vaillant, M, Samouda, H, Mensah, V, Roetynck, S, Kanteh, E, Bowyer, G, Ndaw, A, Oko, F, Bliss, C, Jagne, YJ, Cortese, R, Nicosia, A, Roberts, R, D'Alessio, F, Leroy, O, Faye, B, Cisse, B, Gerry, S, Viebig, N, Lawrie, A, Ewer, K, Hill, A, Nebie, I, Tiono, AB, Sanou, G, Konate, AT, Yaro, BJ, Sodiomon, S, Honkpehedji, Y, Agobe, JCD, Zinsou, F, Mengue, J, Richie, T, Hoffman, S, Nouatin, O, Ngoa, UA, Edoa, JR, Homoet, A, Engelhon, JE, Massinga-Louembe, M, Esen, M, Theisen, M, Sim, KL, Luty, AJ, Moutairou, K, Dinko, B, King, E, Targett, G, Sutherland, C, Likhovole, C, Ouma, C, Vulule, J, Musau, S, Khayumbi, J, Okumu, A, Murithi, W, Otu, J, Gehre, F, Zingue, D, Kudzawu, S, Forson, A, Mane, M, Rabna, P, Diarra, B, Kayede, S, Adebiyi, E, Kehinde, A, Onyejepu, N, Onubogu, C, Idigbe, E, Ba, A, Diallo, A, Mboup, S, Disse, K, Kadanga, G, Dagnra, Y, Baldeh, I, Corrah, T, De Jong, B, Antonio, M, Musanabaganwa, C, Musabyimana, JP, Karita, E, Diop, B, Nambajimana, A, Dushimiyimana, V, Karame, P, Russell, J, Ndoli, J, Hategekimana, T, Sendegeya, A, Condo, J, Binagwaho, A, Okonko, I, Okerentugba, P, Opaleye, O, Awujo, E, Frank-Peterside, N, Moyo, S, Kotokwe, K, Mohammed, T, Boleo, C, Mupfumi, L, Chishala, S, Gaseitsiwe, S, Tsalaile, L, Bussmann, H, Makhema, J, Baum, M, Marlink, R, Engelbretch, S, Essex, M, Novitsky, V, Saka, E, Kalipalire, Z, Bhairavabhotla, R, Midiani, D, Sherman, J, Mgode, G, Cox, C, Bwana, D, Mtui, L, Magesa, D, Kahwa, A, Mfinanga, G, Mulder, C, Borain, N, Petersen, L, Du Plessis, J, Theron, G, Holm-Hansen, C, Tekwu, EM, Sidze, LK, Assam, JPA, Eyangoh, S, Niemann, S, Beng, VP, Frank, M, Atiadeve, S, Hilmann, D, Awoniyi, D, Baumann, R, Kriel, B, Jacobs, R, Kidd, M, Loxton, A, Kaempfer, S, Singh, M, Mwanza, W, Milimo, D, Moyo, M, Kasese, N, Cheeba-Lengwe, M, Munkondya, S, Ayles, H, De Haas, P, Muyoyeta, M, Namuganga, AR, Kizza, HM, Mendy, A, Tientcheu, L, Ayorinde, A, Coker, E, Egere, U, Coussens, A, Naude, C, Chaplin, G, Noursadeghi, M, Martineau, A, Jablonski, N, Wilkinson, R, Ouedraogo, HG, Matteelli, A, Regazzi, M, Tarnagda, G, Villani, P, Sulis, G, Diagbouga, S, Roggi, A, Giorgetti, F, Kouanda, S, Bidias, A, Ndjonka, D, Olemba, C, Souleymanou, A, Mukonzo, J, Kuteesa, R, Ogwal-Okeng, J, Gustafsson, LL, Owen, J, Bassi, P, Gashau, W, Olaf, K, Dodoo, A, Okonkwo, P, Kanki, P, Maruapula, D, Seraise, B, Einkauf, K, Reilly, A, Rowley, C, Musonda, R, Framhein, A, Mpagama, S, Semvua, H, Maboko, L, Hoelscher, M, Heinrich, N, Mulenga, L, Kaayunga, C, Davies, M-A, Egger, M, Musukuma, K, Dambe, R, Usadi, B, Ngari, M, Thitiri, J, Mwalekwa, L, Fegan, G, Berkley, J, Nsagha, D, Munamunungu, V, Bolton, C, Siyunda, A, Shilimi, J, Bucciardini, R, Fragola, V, Abegaz, T, Lucattini, S, Halifom, A, Tadesse, E, Berhe, M, Pugliese, K, De Castro, P, Terlizzi, R, Fucili, L, Di Gregorio, M, Mirra, M, Zegeye, T, Binelli, A, Vella, S, Abraham, L, Godefay, H, Rakotoarivelo, R, Raberahona, M, Randriamampionona, N, Andriamihaja, R, Rasamoelina, T, Cornet, M, De Dieu Randria, MJ, Benet, T, Vanhems, P, Andrianarivelo, MR, Chirwa, U, Michelo, C, Hamoonga, R, Wandiga, S, Oduor, P, Agaya, J, Sharma, A, Cavanaugh, S, Cain, K, Mukisa, J, Mupere, E, Worodria, W, Ngom, JT, Koro, F, Godwe, C, Adande, C, Ateugieu, R, Onana, T, Ngono, A, Kamdem, Y, Ngo-Niobe, S, Etoa, F-X, Kanengoni, M, Ruzario, S, Ndebele, P, Shana, M, Tarumbiswa, F, Musesengwa, R, Gutsire, R, Fisher, K, Thyagarajan, B, Akanbi, O, Binuyo, M, Ssengooba, W, Respeito, D, Mambuque, E, Blanco, S, Mandomando, I, Cobelens, F, Garcia-Basteiro, A, Tamene, A, Topp, S, Mwamba, C, Padian, N, Sikazwe, I, Geng, E, Holmes, C, Sikombe, K, Hantuba, Czaicki, N, Simbeza, S, Somwe, P, Umulisa, M, Ilo, J, Kestelyn, E, Uwineza, M, Agaba, S, Delvaux, T, Wijgert, J, Gethi, D, Odeny, L, Tamandjou, C, Kaindjee-Tjituka, F, Brandt, L, Cotton, M, Nel, E, Preiser, W, Andersson, M, Adepoju, A, Magana, M, Etsetowaghan, A, Chilikwazi, M, Sutcliffe, C, Thuma, P, Sinywimaanzi, K, Matakala, H, Munachoonga, P, Moss, W, Masenza, IS, Geisenberger, O, Agrea, P, Rwegoshora, F, Mahiga, H, Olomi, W, Kroidl, A, Kayode, G, Amoakoh-Coleman, M, Ansah, E, Uthman, O, Fokam, J, Santoro, M-M, Musolo, C, Chimbiri, I, Chikwenga, G, Deula, R, Massari, R, Lungu, A, Perno, C-F, Ndzengue, G, Loveline, N, Lissom, A, Flaurent, T, Sosso, S, Essomba, C, Kpeli, G, Otchere, I, Lamelas, A, Buultjens, A, Bulach, D, Baines, S, Seemann, T, Giulieri, S, Nakobu, Z, Aboagye, S, Owusu-Mireku, E, Danso, E, Hauser, J, Hinic, V, Pluschke, G, Stinear, T, Yeboah-Manu, D, Elshayeb, A, Siddig, ME, Ahmed, AA, Hussien, AE, Kabwe, M, Tembo, J, Chilukutu, L, Chilufya, M, Ngulube, F, Lukwesa, C, Enne, V, Wexner, H, Mwananyanda, L, Hamer, D, Sinyangwe, S, Ahmed, Y, Klein, N, Maeurer, M, Zumla, A, Bates, M, Beyala, L, Etienne, G, Anthony, N, Benjamin, A, Ateudjieu, J, Chibwe, B, Ojok, D, Tarr, CA, Perez, GM, Omeonga, S, Kibungu, F, Meyer, A, Lansana, P, Mayor, A, Onyango, P, Van Loggerenberg, F, Furtado, T, Boggs, L, Segrt, A, Dochez, C, Burnett, R, Mphahlele, MJ, Miiro, G, Mbidde, E, Peshu, N, Kivaya, E, Ngowi, B, Kavishe, R, Maowia, M, Sandstrom, E, Ayuo, E, Mmbaga, B, Leisegang, C, Thorpe, M, Batchilly, E, N'Guessan, J-P, Kanteh, D, Søfteland, S, Sebitloane, M, Vwalika, B, Taylor, M, Galappaththi-Arachchige, H, Holmen, S, Gundersen, SG, Ndhlovu, P, Kjetland, EF, Kombe, F, Toohey, J, Pienaar, E, Kredo, T, Cham, PM, Abubakar, I, Dondeh, BL, Vischer, N, 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Published
2017

47. Gene Injections into Amphibian Oocytes

Author

Melton, D. A., Cortese, R., de Robertis, E. M., Trendelenburg, M. F., Gurdon, J. B., Beermann, W., editor, Gehring, W. J., editor, Gurdon, J. B., editor, Kafatos, F. C., editor, Reinert, J., editor, McKinnell, Robert G., editor, DiBerardino, Marie A., editor, Blumenfeld, Martin, editor, and Bergad, Robert D., editor

Published
1980
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50. Impact of 3 Tesla MRI on diagnosis in clinically isolated syndrome: a MAGNIMS multicentre study

Author

Hagens, M. H. J., Burggraaff, J., Kilsdonk, I. D., Ruggieri, S., Collorone, S., Cortese, R., Cawley, N., Sbardella, E., Andelova, M., Amann, M., Lieb, J. M., Pantano, P., Witte, B. I., Killestein, J., Oreja-Guevara, C., Wuerfel, J., Ciccarelli, O., Gasperini, C., Lukas, C., Rovira, A., Wattjes, M. P., Barkhof, F., Neurology, Radiology and nuclear medicine, Epidemiology and Data Science, Amsterdam Neuroscience - Neuroinfection & -inflammation, and Amsterdam Neuroscience - Brain Imaging

Published
2016

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