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Arabidopsis genome encodes at least 40 histone methyltransferase and only a few of them have been extensively studied. Recently , Berr and colleagues reported SDG2 as the major histone H3 Lysine 4 methyltransferase in Arabidopsis. Indeed, sdg2 lines show pleiotropic defects both at sporophytic and gametophytic level influencing plant size, cell cycle and the development of pollen, ovule and embryo. Among the reproductive anomalies affecting sdg2 mutant, Berr and colleagues reported a female sterility and the formation of triads, dyads and monads at the end of male meiosis. By performing microarray on premeiotic buds Berr and colleagues found a relationship between the gamethophytic defects and the missregulation of known gametophytic genes. However, no hypothesis was made about the causes of meiotic product defects. A further analysis of the microarray data from Berr and collegues was performed in this study in order to get new insights into SDG2 activity. We highlights the possible contribution of two meiotic genes to sdg2 phenotype. Moreover, based on the high number of differentially expressed genes, we confirm that SDG2 is a master regulator of transcription whose effect can be dependent directely on the histone methylation and /or indirectely through the histone acetylation.

Several different classes of secondary metabolites, including flavonoids, triterpenoid saponins and quinic acid derivatives, are found in Aster spp. (Fam. Asteraceae). Several Aster compounds revealed biological as well as pharmacological activities. In this work, a phytochemical investigation of A. caucasicus evidenced the presence of quinic acid derivatives, as well as the absence of triterpene saponins. To combine in one species the production of different phytochemicals, including triterpenes, an Agrobacterium-mediated transformation of A. caucasicus vas set up to introduce A. sedifolius beta-amyrin synthase (AsOXA1)-encoding gene under the control of the constitutive promoter CaMV35S. The quali-quantitative analysis of transgenic calli with ectopic expression of AsOXA1 showed, in one sample, a negligible amount of triterpene saponins combined with higher amount of quinic acid derivatives as compared with the wild type callus.

to describe the characteristics and effectiveness of various smoking cessation programs offered by Italian treatment services operating within the National Health Service.prospective longitudinal multicentre study involving 41 smoking cessation services in 16 Italian regions.the study population includes patients entering smoking cessation programs between April 2003 and June 2004. The "study population" includes 1226 patients (54.2% males and 45.4% females), mean age 47 years. Patients have a middle/high level of education and a long history of smoking; most are highly dependent on nicotine and report previous attempts to quit smoking.treatment effectiveness in smoking cessation is assessed six months after entering treatment service. Logistic Regression Model was used to determine the predictors of successfiul cessation, independent of treatment typology. The predictors were included as confounding variables in the logistic regression model that was used to evaluate the effectiveness of treatments. Besides the effect of treatment completion on smoking cessation was estimated.predictors of successful smoking cessation are: being male, presence of a partner, strong motivation to quit, previous attempts to give up smoking, mild nicotine dependence, and not suffering from mood disturbances. All treatments are effective in helping people to stop smoking: cessation rate ranges between 25.00% for patients receiving a single session of motivational counselling and 65.3% for those receiving nicotine replacement therapy combined to group therapy. Compared to a single session of motivational counseling, nicotine replacement therapy combined to group therapy is the most effective therapeutic program (OR 5.4; 95%CI 12.5-12.0). Treatment completion is a strong determinant ofsuccess (OR 4.8; 95%CI 3.5-6.4).enrolling people in any type of therapeutic program, in particular nicotine replacement therapy combined with group therapy increases the probability of successfully quitting smoking; moreover, patients that begin a smoking cessation program should be encouraged to complete the therapy

This paper provides an analysis of flight technical error (FTE) from recent SATS experiments, called the higher volume operations (HVO) simulation and flight experiments, which NASA conducted to determine pilot acceptability of the HVO concept for normal operating conditions. Reported are FTE results from simulation and flight experiment data indicating the SATS HVO concept is viable and acceptable to low-time instrument rated pilots when compared with today's system (Baseline). Described is the comparative FTE analysis of lateral, vertical, and airspeed deviations from the Baseline and SATS HVO experimental flight procedures. Based on FTE analysis, all evaluation subjects, low-time instrument-rated pilots, flew the HVO procedures safely and proficiently in comparison to today's system (Baseline). In all cases, the results of the flight experiment validated the results of the simulation experiment and confirm the utility of the simulation platform for comparative human in the loop (HITL) studies of SATS HVO and Baseline operations.

A collection of folklore and local history stories from Star of the Sea Convent, Tramore (school) (Tramore, Co. Waterford), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Sr. M. Consiglio., Dunhill Castle / Veale, Brigid -- Danes Island / Veale, Brigid -- Sea Horse / Murphy, Maura -- Place Names -- Stories / Bluett, Kitty -- Stories / Bluett, Kitty -- Once upon a time there was a man who was a landlord. / Kirwan, Kitty -- Burrow / Sullivan, Ursula O' -- Sheevra / Phelan, Breda -- Story of Fenor / Malone, Maureen -- Story of the Sheevra / Power, Biddy -- Nicknames -- Customs - Wakes / Giles, Peggy -- Piseoga / Lynch, Kitty -- Piseog / Kirwan, Kitty -- Old Customs -- Tomhasanna / Lynch, Alice -- Tomhasanna -- Ranna -- Lullaby, Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.