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The long interspersed element-1 (LINE-1, hereafter L1) retrotransposon has generated nearly one-third of the human genome and serves as an active source of genetic diversity and human disease1. L1 spreads through a mechanism termed target-primed reverse transcription, in which the encoded enzyme (ORF2p) nicks the target DNA to prime reverse transcription of its own or non-self RNAs2. Here we purified full-length L1 ORF2p and biochemically reconstituted robust target-primed reverse transcription with template RNA and target-site DNA. We report cryo-electron microscopy structures of the complete human L1 ORF2p bound to structured template RNAs and initiating cDNA synthesis. The template polyadenosine tract is recognized in a sequence-specific manner by five distinct domains. Among them, an RNA-binding domain bends the template backbone to allow engagement of an RNA hairpin stem with the L1 ORF2p C-terminal segment. Moreover, structure and biochemical reconstitutions demonstrate an unexpected target-site requirement: L1 ORF2p relies on upstream single-stranded DNA to position the adjacent duplex in the endonuclease active site for nicking of the longer DNA strand, with a single nick generating a staggered DNA break. Our research provides insights into the mechanism of ongoing transposition in the human genome and informs the engineering of retrotransposon proteins for gene therapy.

Introduction: The coach-athlete relationship is not merely a by-product of the coaching process but serves as its foundation. Coaches today must align their approaches with the characteristics (character, strengths, and growth areas) of a new generation of athletes, commonly referred to as Generation Z (Gen Z). Born between 1995 and 2012, Gen Z's grew up in a digital age, which shaped their character and behaviour. The purpose of the study was to explore coach-athlete relationships, the characteristics of Gen Z athletes that influence this relationship, and the process of building healthy coach-athlete relationships, from the perspectives of coaches. Methods: The study used a qualitative methodology to elicit the perspectives of 11 male rugby union coaches (M ± SD age: 42.09 ± 7.56 years; with 12.83 ± 3.48 years of coaching experience), through semi-structured individual online interviews. We developed the interview script from Jowett's Coach-Athlete Relationship Questionnaire (CART-Q). The interviews were analysed using Merriam and Tisdell's six-step process. Findings: The analysis yielded six super themes (and 17 themes). 1. Coach perspectives on coaching Gen Z players (developmental facilitators and debilitators, Covid-19's effect on development). 2. Closeness between coaches and athletes [loving and caring, getting closer, trusting, (not) respecting some players]. 3. Commitment (personally and towards the team, sacrifices). 4. Complementarity (goal setting, collectively working towards common goals). 5. Co-orientation (communicating, reciprocal relationship views). 6. Developing the coach-athlete relationship (approaches thereto, practical steps). Discussion: Various facets of the coach-athlete relationship are interlinked and shaped by the characteristics and behaviours of this generation of athletes. Practical recommendations are offered on how to cultivate the coach-athlete relationship on emotional, cognitive, and behavioural levels. [ABSTRACT FROM AUTHOR]

mRNA measurement is dominated by RT-PCR, which requires expensive laboratory equipment and personnel with advanced degrees. Loop-mediated isothermal amplification (LAMP) is a versatile technique for detecting target DNA and RNA. The sensitivity of LAMP in early reports has been below that of the standard RT-PCR tests. Here, we report the use of a fluorescence-based RT-LAMP protocol to measure CDX2 expression patterns, which match extremely well to the standards of sophisticated RT-PCR techniques (r = 0.99, p

BACKGROUND: Stress and anxiety during pregnancy are extremely prevalent and are associated with numerous poor outcomes, among the most serious of which are increased rates of preterm birth and low birth weight infants. Research supports that while in-person mindfulness training is effective in reducing pregnancy stress and anxiety, there are barriers limiting accessibility. OBJECTIVE: The aim of this paper is to determine if mindfulness meditation training with the Headspace app is effective for stress and anxiety reduction during pregnancy. METHODS: A longitudinal, single-arm trial was implemented with 20 pregnant women who were instructed to practice meditation via the Headspace app twice per day during the month-long trial. Validated scales were used to measure participants levels of stress and anxiety pre- and postintervention. Physiological measures reflective of stress (heart rate variability and sleep) were collected via the Oura Ring. RESULTS: Statistically significant reductions were found in self-reported levels of stress (P=.005), anxiety (P=.01), and pregnancy anxiety (P

Abstract Purpose This study aimed to review the literature on complementary and alternative therapies, utilizing text mining and trend analysis in nursing research. As CAM becomes increasingly prevalent in healthcare settings, a comprehensive understanding of the current research landscape is essential to guide evidence-based practice, inform clinical decision-making, and ultimately enhance patient outcomes. Method This study aimed to identify CAM-related literature published from 2018 to 2023. Using the search terms 'complementary therap*', 'complementary medicine', 'alternative therap*', and 'alternative medicine', we performed a comprehensive search in eight databases, including EMBASE, Cochrane Central, PubMed Central, Korea Education and Research Information Service (RISS), Web of Science, KMbase, KISS, and CINAHL. From the text network and topic modeling analysis of 66,490 documents, 15 topics were identified. These topics were classified into two nursing-related topics through an academic classification process involving three doctors with doctoral degrees, three nurses, and three pharmacists. Based on the classified topics, research trends were comparatively analyzed by re-searching the database for 12 nursing and 22 non-nursing literature. Result This study found that in nursing literature, yoga is used to improve mental symptoms such as stress and anxiety. In non-nursing literature, most of the experimental studies on complementary and alternative therapies were conducted in a randomized manner, confirming that a variety of physiological and objective indicators were used. Additionally, it was discovered that there were differences in the diversity of research subjects and research design methods for the same intervention method. Therefore, future research should focus on broadening the scope of subjects and measurement tools in nursing studies. Additionally, such studies should be conducted with randomization and generalizability in the experimental design in mind. Conclusion This study employed text network analysis and text mining to identify domestic and international CAM research trends. Our novel approach combined big data-derived keywords with a systematic classification method, proposing a new methodological strategy for trend analysis. Future nursing research should focus on broadening the scope of subjects, diversifying measurement tools, and emphasizing randomization and generalizability in experimental designs.

Background The challenges of the COVID-19 pandemic extend to concerns about vaccine side effects, particularly potential links to neurodegenerative diseases such as Alzheimer's disease (AD). Aim This study investigates the association between COVID-19 vaccination and the onset of AD and its prodromal state, mild cognitive impairment (MCI). Design A nationwide, retrospective cohort study leveraging data from the Korean National Health Insurance Service was conducted. Methods The study, conducted in Seoul, South Korea, analyzed data from a random 50% sample of city residents aged 65 and above, totaling 558 017 individuals. Participants were divided into vaccinated and unvaccinated groups, with vaccinations including mRNA and cDNA vaccines. The study focused on AD and MCI incidences post-vaccination, identified via ICD-10 codes, using multivariable logistic and Cox regression analyses. Patients with vascular dementia or Parkinson's disease served as controls. Results Findings showed an increased incidence of MCI and AD in vaccinated individuals, particularly those receiving mRNA vaccines, within three months post-vaccination. The mRNA vaccine group exhibited a significantly higher incidence of AD (odds ratio [OR]: 1.225; 95% confidence interval [CI]: 1.025–1.464; P  = 0.026) and MCI (OR: 2.377; CI: 1.845–3.064; P  < 0.001) compared to the unvaccinated group. No significant relationship was found with vascular dementia or Parkinson's disease. Conclusions Preliminary evidence suggests a potential link between COVID-19 vaccination, particularly mRNA vaccines, and increased incidences of AD and MCI. This warrants the need for further research to elucidate the relationship between vaccine-induced immune responses and neurodegenerative processes, advocating for continuous monitoring and investigation into the vaccines' long-term neurological impacts. [ABSTRACT FROM AUTHOR]

Community language schools provide language and cultural education to young people. Forming a key education sector worldwide with an estimated two million enrolments, these community-run, out-of-hours schools nonetheless tend to be marginalised by 'mainstream' education and 'mainstream' educational research. There has been a dramatic increase in research into community language schools in the past two decades, but there is still no systematic review that analyses the education role and contribution of this sector. This study aims to provide a clear picture of the extent, nature and gaps in the existing research into community language schools from 2001 to 2023. The study tracks how the research focus has shifted and grown in the past decades, but also highlights that the marginalisation of community language schools and research remains. The study directs researchers to relevant publications and suggests issues and topics in need of further research. [ABSTRACT FROM AUTHOR]

BACKGROUND: The use of herbal products, one component of the growing field of integrative cancer care, is a common yet controversial practice. OBJECTIVES: This article distinguishes nursing issues specific to patient safety when herbal products are used during cancer treatment and identifies available evidence-based resources to enhance patient and professional comprehension. METHODS: PubMed®, CINAHL®, and Google Scholar™ databases were searched for literature published between 2018 and 2024 specific to the clinical sequelae of the use of herbal products and their interactions with antineoplastic drugs, as well as patient and healthcare providers' perceptions of efficacy and safety. METHODS: PubMed®, CINAHL®, and Google Scholar™ databases were searched for literature published between 2018 and 2024 specific to the clinical sequelae of the use of herbal products and their interactions with antineoplastic drugs, as well as patient and healthcare providers' perceptions of efficacy and safety. [ABSTRACT FROM AUTHOR]

Analytical or synthetic knowledge is widely considered beneficial for eco‐innovation (EI). For a firm, analytical and synthetic knowledge can be acquired externally through collaboration with various partners or generated internally through R&D and other internal firm activities. However, evidence supporting the assumption that both forms of knowledge are complementary and that "doing more of all" will benefit EI is unclear. We found that external analytical and synthetic knowledge and internal analytical and synthetic knowledge all positively affect EI, with internal analytical being the most prominent. However, combining analytical and synthetic knowledge may not be beneficial for EI. The interaction between analytical and external synthetic knowledge is generally substitutive. We found a particularly significant substitutive effect between internal analytical and internal synthetic knowledge, as well as between internal analytical and external synthetic knowledge. In short, we found little evidence of complementarity between analytical and synthetic knowledge, regardless of where it is acquired from. These findings advise caution to firm managers and policymakers who are considering strategies to combine different forms of knowledge from different sources to successfully achieve EI goals. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to review the literature on complementary and alternative therapies, utilizing text mining and trend analysis in nursing research. As CAM becomes increasingly prevalent in healthcare settings, a comprehensive understanding of the current research landscape is essential to guide evidence-based practice, inform clinical decision-making, and ultimately enhance patient outcomes. Method: This study aimed to identify CAM-related literature published from 2018 to 2023. Using the search terms 'complementary therap*', 'complementary medicine', 'alternative therap*', and 'alternative medicine', we performed a comprehensive search in eight databases, including EMBASE, Cochrane Central, PubMed Central, Korea Education and Research Information Service (RISS), Web of Science, KMbase, KISS, and CINAHL. From the text network and topic modeling analysis of 66,490 documents, 15 topics were identified. These topics were classified into two nursing-related topics through an academic classification process involving three doctors with doctoral degrees, three nurses, and three pharmacists. Based on the classified topics, research trends were comparatively analyzed by re-searching the database for 12 nursing and 22 non-nursing literature. Result: This study found that in nursing literature, yoga is used to improve mental symptoms such as stress and anxiety. In non-nursing literature, most of the experimental studies on complementary and alternative therapies were conducted in a randomized manner, confirming that a variety of physiological and objective indicators were used. Additionally, it was discovered that there were differences in the diversity of research subjects and research design methods for the same intervention method. Therefore, future research should focus on broadening the scope of subjects and measurement tools in nursing studies. Additionally, such studies should be conducted with randomization and generalizability in the experimental design in mind. Conclusion: This study employed text network analysis and text mining to identify domestic and international CAM research trends. Our novel approach combined big data-derived keywords with a systematic classification method, proposing a new methodological strategy for trend analysis. Future nursing research should focus on broadening the scope of subjects, diversifying measurement tools, and emphasizing randomization and generalizability in experimental designs. [ABSTRACT FROM AUTHOR]

Objective: This study was carried out to determine the complementary and alternative treatment methods used by women in the postmenopausal period and their effects on menopausal symptoms and quality of life. Material-Method: This study was designed as a cross -sectional and correlational study, and it was conducted at a Family Health Center in a province in the Southeast Anatolia Region of Türkiye between March and August 2018. The sample consisted of 259 postmenopausal women aged 45-60 registered at the Family Health Center. Data were collected using the Personal Information Form, the Menopause Rating Scale, and the Short -Form 36 (SF-36) Quality of Life Scale. The face-toface interview technique was employed for data collection. Descriptive statistics, Pearson's correlation c oefficient, and multiple linear regression (MLR) analyses were used to analyze the data. Results: It was determined that 77.6% of the women in the postmenopausal period used complementary and alternative treatment methods to reduce menopausal symptoms. The analysis revealed that as postmenopausal women increasingly utilized nutrition, vitamins, and minerals as complementary and alternative medicine methods, their physical role limitations, a subdimension of quality of life, decreased (ß = -0.359; p < 0.05). Additionally, physical functioning, another subdimension of quality of life, improved with the increased use of mind -body techniques as a complementary and alternative medicine method (ß = 0.273; p < 0.05). Conclusion: Nutritional, vitamin, and mineral treatments were significant predictors of physical role limitations in postmenopausal women, which is a subdimension of quality of life. Similarly, mind-body techniques were found to be significant predictors of physical functioning. [ABSTRACT FROM AUTHOR]

The diversified innovative strategies adopted by the new retail format in urban spaces have significantly driven retail transformation and innovation. The combination of online platforms and physical stores provides a substantial advantage in market competition. This paper takes "Freshippo", a typical representative of China's new retail, as an example. Based on multi-source data and using tools such as GIS spatial analysis, statistical analysis, and geographical detectors, this study comprehensively examines the spatial clustering characteristics and influencing factors of Freshippo physical stores in Shanghai. The findings show that Freshippo has significantly expanded in the Shanghai fresh food market by innovatively opening various types of stores. However, there are substantial differences in the proportions of different types of stores, with 94% of the stores having online retail capabilities. Each offline store in the new retail format presents a multi-level "complementary" spatial distribution feature across the urban space, with distinctive clusters in the urban central districts, urban periphery areas, and outer suburban districts. The radiation range of logistics and distribution services exhibits characteristics of "central agglomeration and multi-point distribution", providing residents with diverse and accurate services. Additionally, the comparison of multiple model results shows that the location selection of various types of new retail stores is significantly influenced by multiple factors, especially the nonlinear amplification effect of factor interactions on store agglomeration. These findings provide an important scientific reference for understanding the development of new retail formats and offer new ideas that promote the transformation and innovation of the retail industry, thereby achieving sustainable development. [ABSTRACT FROM AUTHOR]

Purpose of Review: Traditional, complementary, and integrative medicine (TCIM) modalities are widely employed. However, TCIM, specifically herbal and non-herbal dietary supplements, can pose challenges in the context of organ transplantation. In this review, we discuss common supplements used for psychiatric purposes and highlight important considerations for candidates and recipients of liver transplants. Recent Findings: Ashwagandha, kava kava, green tea extract, skullcap, turmeric, and valerian have known idiosyncratic hepatotoxic potential and may complicate the liver transplantation course. Multiple supplements reportedly carry a lower risk of hepatotoxicity, though evidence for widespread use in those at risk for or with hepatic impairment is limited. Summary: Psychiatrists caring for candidates and recipients of liver transplants must recognize that patients may find supplements helpful in alleviating psychiatric symptoms, despite an overall limited evidence base. Evaluating benefit versus risk ratios and reviewing drug-drug interactions is essential to promote transplant candidacy and mitigate the possibility of native or graft liver dysfunction. [ABSTRACT FROM AUTHOR]

Motivated by the rapid advancement of large language models (LLMs), this study explores the potential impact of them on agricultural labor market. Starting from the task level of each of the 15 selected occupations, their exposure to LLMs was assessed by rating the extent to which the required abilities are aligned with those of LLMs, taking also into account the importance of the abilities in each occupation. Findings indicate that while LLMs can significantly enhance cognitive functions, they cannot fully replace the physical, psychomotor, and sensory abilities. As a consequence, while certain tasks are either partially or highly susceptible to LLM implementation, a considerable proportion, involving manual responsibilities, remains largely unaffected. It was seen that occupations heavily reliant on data are at greater risk of substitution. Conversely, some occupations will probably experience an augmenting effect, as LLMs will automate certain cognitive routine tasks, freeing up human workers to focus on more creative non-routine aspects. Furthermore, a negative correlation between exposure to LLMs and exposure to robotization was found highlighting the interconnected dynamics between these two variables within the analyzed context. In conclusion, although LLMs can offer substantial benefits, their integration necessitates careful consideration of their inherent limitations to maximize efficacy and mitigate risks in the agricultural sector.

Background: Complementary feeding is the corner stone of child’s nutrition. Most malnourished children had their predicament originating from the period of transition from breast-feeding to family diet. Objectives: To determine the complementary feeding practices and nutritional status of young children in Gwiwa community. Materials and Methods: This cross-sectional study was carried out in Gwiwa community, Wam- makko LGA, Sokoto State between January and June, 2018. Three hundred and ten mothers with their children aged 6 – 36 months were interviewed using structured interviewer administered questionnaire and the children’s nutritional status was assessed using WHO classification of malnutrition. Data was analysed using SPSS version 22.0.A pvalue ≤0.05 was taken as significant Results: One hundred and forty (45.2%) respondents were aged 15 – 24years and 168(54.2%) were of low socio- economic class. There were 190 males and 120 females with 66 (21.3%) children exclusively breast fed for 6months. The mean age of cessation of breast feeding was 17.8 ±3.6 months. One hundred and sixty-nine (54.5%) children commenced complementary feeding at 6 - 8month of age with the mean age of 5.7(±2.6) months. One hundred and eighty- four (59.4%) used plain pap with 41.2% fed more than 3 times per day. Eighty – two (26.5%), 56(18.1%) and 76 (24.5%) children were under weight, wasted and stunted respectively. Conclusion: The complementary feeding practices were suboptimal in this community and might explain the poor nutritional status of their under fives. Efforts should be geared towards optimal complementary feeding practices in this community.

Since its discovery in 2016, the Polerovirus Barley virus G has been reported in at least nine countries and multiple species of monocot plants. All of these reports have used PCR and/or sequencing based assays to identify BVG, however none have investigated the biology of BVG. In this study we detail the generation of the first infectious cDNA clone of BVG from archived RNA, thereby producing a valuable experimental tool and system for studying BVG biology. Using this system we identified two compatible aphid vectors and confirmed the susceptibility of several monocot plants, and the dicotyledonous plant host Nicotiana benthamiana, to BVG.

Our present study is made to use the trnH-psbA spacer gene data to resolve some phylogenetic relationships among the Eucalyptus speices. The species included are E. moorei, E.affn. moorei, E. dives, E. mitchelliana, E. pauciflora and E. stellulata. There were successful amplifications of DNA for the seven Eucalyptus species using gene trnH-psbA. The trnH-psbA spacer is the short with 476 bps. It is to be complimented with rbcL, MatK and trnH-psbA gene study. The trnH-psbA spacer is showing 21 SNPs out of 476 bps segment. The mean length is 733 bps long. Amplification success rate is almost 100%. For each species there are multiple good quality sequences available for the sequence alignment. The trnH-psbA spacer has discriminated 5 species clearly from the rest and the other 3 species are also separated from each other though the distance between them is not significantly noticeable. [ABSTRACT FROM AUTHOR]

Object: This cross-sectional study aims to investigate migraineurs’ preferred complementary and alternative medicine (CAM) types and the factors influencing their usage. Materials and methods: An anonymous e-survey was distributed to Lithuanian Migraine Association members, and social media migraine support communities. The collected data consisted of demographic, migraine-related questions, personal qualities, CAM habits. Results: 470 respondents were analyzed. 95.96% were women with a median age of 37 (IQR 31, 44). The median duration of migraine was 17.5 years (IQR 10, 25) and the median headache severity was rated 8 (IQR 7, 10) out of 10. 68.90% of participants had one or more headache days per week. 71.49% of respondents were triptan users, 27.66% used medical prophylaxis, and 17.87% used monoclonal antibodies. 52.55% of respondents used CAM in the past 12 months. Physical activity (36.17%), dietary changes/fasting (27.02%), relaxation/meditation (26.60%) were the most used CAM types. Reasons for CAM use included dissatisfaction with conventional treatment effectiveness (42.51%), concerns about safety (48.18%) and adverse effects (37.25%). Factors associated with the decision to explore CAM included longer headache duration (p = 0.017, Mann–Whitney U test), frequent sick leaves (p < 0.001, Mann–Whitney U test), current preventive medication use (p = 0.016, chi-square test), positive views on CAM safety/naturality (p = 0.001/ p < 0.001, Mann–Whitney U test), belief of having a healthy diet (p < 0.001, chi-square test), food-related worries (p = 0.011, Mann–Whitney U test) and Big-five personality trait of openness to experience (p = 0.049, chi-square test). After logistic regression, the frequent need to take sick leaves, having a healthy diet, food-associated fears maintained statistical significance. CAM use was not associated with non-adherence to conventional medicine. 48.99% of CAM consumers disclosed CAM use to their doctors. Conclusion: CAM is explored by a significant proportion of migraineurs, less than half communicate this to their doctors. In our sample, physical activity, dietary changes, and relaxation techniques were the most common. Many patients opted for CAM due to previously experienced side effects/ineffectiveness of conventional migraine treatment or the fear of potential harm from standard medication. Individual factors, such as openness of personality can be an important contributing factor. [ABSTRACT FROM AUTHOR]

Purpose of Review: The goal of this review is to summarize updates to the broad array of complementary therapies available for cancer pain. This paper will serve as a reference for clinicians managing pain in cancer patients. Recent Findings: Patients are embracing integrative therapies in growing numbers; clinicians must be prepared to incorporate these therapies into patients' existing treatment regimens. This requires knowledge regarding risks, benefits, and potential interactions with existing cancer therapies. Summary: Integrative cancer pain management strategies have shown promise, with several proven effective for the management of cancer pain. Energy therapies, including acupuncture, and biologicals and nutraceuticals including overall diet and vitamin D, have the highest level of evidence for efficacy. The remaining therapies discussed in this chapter may be beneficial for patients on a case-by-case basis; risks and benefits of each individual therapy as described in the text must be further assessed in future rigorous trials to further clarify the role of these complementary therapies in cancer pain management. [ABSTRACT FROM AUTHOR]

Introduction: Hypertension is the most dominant risk factor for cardiovascular disease, which is the most frequent cause of deaths all over the world. Patients' hypertension requires nonpharmacological interventions as an integral part of case management. Complementary and alternative medicine are recognized and accepted in several countries, also could be recommended for lowering blood pressure. The aim of this study is to explore the most popular method of CAM used for hypertension. Method: This study was conducted by searching online databases between 2012 - 2022, using PRISMA 2020 to find specific articles. The PICOT framework that be used: adult with hypertension, complementary use, blood pressure. Articles were sourced from Elsevier, Plos One, NIH, Lancet, BMC, Sage, Springer, Wiley, Lippincott, and Garuda. The researcher obtained 23 articles for final review, with inclusion criteria for people with hypertension that use CAM as a therapy to prevent elevated blood pressure. Result: 10 articles were RCT, 7 articles were cross sectional, 4 articles were experiments, 1 article was cohort, and 1 article was mixed method. The result showed that the CAM was effective in lowering blood pressure. People with hypertension most often used herbal medicine, acupuncture, massage, acupressure, yoga, meditation, tai chi, reflexology, guided imagery, and aromatherapy oil (in sequentially). Conclusion: Perception/belief, lack of information, experience and culture affect people's behavior in choosing medical drugs over CAM. Therefore, health care should promote CAM and provide patients with non-pharmacological intervention. [ABSTRACT FROM AUTHOR]

IntroductionThe coach-athlete relationship is not merely a by-product of the coaching process but serves as its foundation. Coaches today must align their approaches with the characteristics (character, strengths, and growth areas) of a new generation of athletes, commonly referred to as Generation Z (Gen Z). Born between 1995 and 2012, Gen Z's grew up in a digital age, which shaped their character and behaviour. The purpose of the study was to explore coach-athlete relationships, the characteristics of Gen Z athletes that influence this relationship, and the process of building healthy coach-athlete relationships, from the perspectives of coaches.MethodsThe study used a qualitative methodology to elicit the perspectives of 11 male rugby union coaches (M ± SD age: 42.09 ± 7.56 years; with 12.83 ± 3.48 years of coaching experience), through semi-structured individual online interviews. We developed the interview script from Jowett's Coach-Athlete Relationship Questionnaire (CART-Q). The interviews were analysed using Merriam and Tisdell's six-step process.FindingsThe analysis yielded six super themes (and 17 themes). 1. Coach perspectives on coaching Gen Z players (developmental facilitators and debilitators, Covid-19's effect on development). 2. Closeness between coaches and athletes [loving and caring, getting closer, trusting, (not) respecting some players]. 3. Commitment (personally and towards the team, sacrifices). 4. Complementarity (goal setting, collectively working towards common goals). 5. Co-orientation (communicating, reciprocal relationship views). 6. Developing the coach-athlete relationship (approaches thereto, practical steps).DiscussionVarious facets of the coach-athlete relationship are interlinked and shaped by the characteristics and behaviours of this generation of athletes. Practical recommendations are offered on how to cultivate the coach-athlete relationship on emotional, cognitive, and behavioural levels.

Purpose: Hypertension is the primary cause of mortality. Hence globally, there is a growing interest in complementing antihypertensive drugs with herbs to alleviate blood pressure among hypertensive patients. Thus, this review aimed to evaluate the effectiveness of complementing drugs with herbs on blood pressure and lipid profile outcomes, the associated factors and the types of complementary herbs alongside their consumption regimes. Methods: This review is registered in PROSPERO on the National Institute of Health Database with an ID: CRD42021270481. Using the PICOS (population, intervention, comparison, outcome, study type) mnemonic formula and search strategy, we searched (January 2010 to February 2024) five electronic databases including Pubmed, Scopus, Web of Science, CINAHL (Cumulative Index for Nursing and Allied Health Literature) and Psychology & Behavioral Sciences Collection (PBSC). The inclusion criteria of the review were that all included papers had to be randomised control trials in English among hypertensive adults who complemented antihypertensive drugs with herbs. A Cochrane risk of bias assessment as well as a meta-analysis and narrative synthesis were conducted to answer the objectives. Results: Twenty-five randomised controlled trials involving 1996 participants from 14 countries were included. The risk of bias among included articles was assessed and presented using the Cochrane risk of bias tool and the graphs were generated. The effects of complementing antihypertensive drugs with different herb regimes on blood pressure and lipid profile outcomes were compared to those solely on antihypertensive drugs and placebo via a random model effects meta-analysis using the Revman manager. Systolic blood pressure (SBP) and triglycerides gave a significant reduction in favour of the intervention group which complemented herbs. The overall pooled systolic blood pressure showed a reduction of (SMD=0.81, 95 % CI 0.14–1.47, p

Gastrin-releasing peptide (GRP) and its receptor (GRPR) have been identified as itch mediators in the spinal and trigeminal somatosensory systems in rodents. In primates, there are few reports of GRP/GRPR expression or function in the spinal sensory system and virtually nothing is known in the trigeminal system. The aim of the present study was to characterize GRP and GRPR in the trigeminal and spinal somatosensory system of Japanese macaque monkeys (Macaca fuscata). cDNA encoding GRP was isolated from the macaque dorsal root ganglion (DRG) and exhibited an amino acid sequence that was highly conserved among mammals and especially in primates. Immunohistochemical analysis demonstrated that GRP was expressed mainly in the small-sized trigeminal ganglion and DRG in adult macaque monkeys. Densely stained GRP-immunoreactive (ir) fibers were observed in superficial layers of the spinal trigeminal nucleus caudalis (Sp5C) and the spinal cord. In contrast, GRP-ir fibers were rarely observed in the principal sensory trigeminal nucleus and oral and interpolar divisions of the spinal trigeminal nucleus. cDNA cloning, in situ hybridization, and Western blot revealed substantial expression of GRPR mRNA and GRPR protein in the macaque spinal dorsal horn and Sp5C. Our Western ligand blot and ligand derivative stain for GRPR revealed that GRP directly bound in the macaque Sp5C and spinal dorsal horn as reported in rodents. Finally, GRP-ir fibers were also detected in the human spinal dorsal horn. The spinal and trigeminal itch neural circuits labeled with GRP and GRPR appear to function also in primates.

Purpose of reviewIntegrative medicine is the practice of combining conventional medical treatments with "alternative" or "complementary" therapies. Integrative psychiatry is a holistic, person-centered approach to neuropsychiatric disorders that emphasizes a person's physical, emotional, interpersonal, behavioral, nutritional, environmental, and spiritual dimensions to achieve well-being. Older adults are more prone to physical injury, interpersonal loss, chronic illnesses, and physical and cognitive decline that can manifest as anxiety, depression, with functional decline and inability to care for self. Additionally, stress of caring for older adults with dementia can adversely affect caregivers' health. Although integrative approaches are perceived as safer and less stigmatizing, it is important to understand the risks and benefits of such therapies for older adults with neurocognitive disorders and their caregivers.Recent findingsHere, we summarize the results of the recent clinical trials and meta-analyses that provide evidence for integrative approaches to treating older adults with cognitive disorders and their caregivers which include the use of diet and supplements, and mind-body therapies. Dietary and mind-body therapies have become increasingly popular and show the strongest evidence of effectiveness for cognitive disorders and caregiver stress. Vitamins and supplements are the most popular integrative intervention, but there is mixed evidence supporting their use and the concern for herb (supplement)-drug interactions. While there is increasing popularity of integrative treatments, information to guide clinicians providing care for older adults remains limited, with variable scientific rigor of the available RCTs for a large number of commonly used integrative interventions particularly for cognitive disorders and caregiver stress and well-being.

Pain is one of the symptoms that is often found in any changes in body health. This PKM aims to provide the training to increase knowledge through socialization and outreach to the people at Campus and community in Bukittinggi. From this explanatory background, we conclude that using application is more effective to manage the pain. The purpose of implementing this PASHA is to help the pain problems with promotion methods by using complementary therapies on application. The method that has been used in this PKM includes scialization related to Complementary Based of Pain Management by using PASHA (Pain Assessment, Stimulation and Healing Application). The evaluation results showed a reduction in pain intensity by measuring the pain scale before and after being given pain management interventions through the PASHA (Pain Assessment, Stimulation and Healing) application. A measurement was use NRS and the average pain before and after is calculated. The results obtained were a decrease in the average pain before and after using PASHA. It is hoped that the campus and surrounding community will be able to continue the activities of using this application in pain management so that it can be used to improve the level of health in the community. [ABSTRACT FROM AUTHOR]

Music is helpful to young people in healthcare contexts, but less is known about the acceptability of music-based interventions for youth living at home with chronic pain who may be struggling to attend school and participate in social activities. The Songs of Love (SOL) foundation is a national nonprofit organization that creates free, personalized, original songs for youth facing health challenges. The aims of this study were (1) to assess acceptability of SOL from the perspective of youth with chronic pain receiving a song and singer-songwriters who created the songs, and (2) to explore the role of music more generally in the lives of young people living with pain. Twenty-three people participated. Fifteen youth (mean age 16.8) were interviewed and received a song, and six singer-songwriters were interviewed about creating the songs. (Two additional people participated in pilot interviews.) Acceptability was assessed by (1) proportion of youth who participated in a second interview about their song and (2) results of reflexive thematic analysis (RTA) to determine acceptability. Themes addressing the role of music in the lives of youth with pain were also explored using RTA. The program was acceptable as 12 of 15 youth (80 %) participated in second interviews and themes met the definition of acceptability. Three themes addressing the role of music in the lives of youth living with pain were identified. This is the first report of the acceptability and experience of SOL and contributes to research on the benefits of music for pain management. [ABSTRACT FROM AUTHOR]

This work presents a design for a complementary antenna with circular polarization that has a wide operating bandwidth, stable broadside radiation, and stable gain for X-band applications. The proposed antenna consists of an irregular loop and a parasitic electric dipole, which work together to produce equivalent radiation from the magnetic and electric dipoles. By arranging the dipole and the loop in a specific geometry, this antenna effectively generates circularly polarized wave propagation. A substrate integrated coaxial line (SICL) is applied to feed the antenna through an aperture cutting on the ground. The proposed antenna achieves a wide axial ratio (AR) and impedance bandwidths of 27.4% (from 8.5 to 11.22 GHz, for the AR ≤ 3 dB) and 39.6% (from 7.5 to 11.2 GHz, for the reflection coefficient ≤ −10 dB), respectively. Moreover, the antenna maintains a stable broadside radiation pattern across the operating bandwidth, with an average gain of 10 dBic. This proposed antenna design is competitive for X-band wireless communications. [ABSTRACT FROM AUTHOR]

Objectives The growing occurrence of bacterial resistance has spawned the development of novel antimicrobial agents. Antimicrobial peptides, a class of small molecules with antimicrobial activity, have been regarded as the ideal alternatives to antibiotics. Methods In this study, we amplified a new type of Zophobas atratus coleoptericin (denoted coleoptericin B) through rapid amplification of cDNA ends (RACE) PCR and expressed recombinant Z. atratus coleoptericin B (rZA-col B) by prokaryotic expression. Subsequently, we evaluated the antimicrobial effect and biocompatibility of rZA-col B in vivo , investigated its antimicrobial mechanism, and assessed its therapeutic effect in a murine model of mastitis caused by MDR Klebsiella pneumoniae. Results The in vivo studies demonstrated that rZA-col B possesses broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. It exhibited less than 1.5% haemolysis and 10% cytotoxicity, even at a concentration of 128 μM. Additionally, rZA-col B had a minimal risk of inducing drug resistance. Furthermore, rZA-col B could disrupt the integrity of bacterial membranes, induce membrane permeabilization and ultimately lead to bacterial death. Importantly, rZA-col B also alleviated mastitis caused by MDR K. pneumoniae in a murine model by enhancing bacterial clearance, reducing neutrophil infiltration, decreasing TNF-α and IL-1β expression, and protecting the mammary barrier. Conclusions rZA-col B may be a promising antibacterial agent to combat MDR bacterial infection. [ABSTRACT FROM AUTHOR]

Background: The introduction of complementary food is the most important factor determining the nutritional status of the children in the first 2 years of life. This study aimed to find out the determinants and patterns of complementary feeding practices and their impact on the growth and development of children of 6–24 months of age group. Materials and Methods: A descriptive cross-sectional study was done on immunization out patient department (OPD) in the field practice area of the Department of Community Medicine. The sample size taken was 250 using a systematic random sampling method. Results: One hundred and seven (42.8%) were given the optimum amount of complementary food for their age. One hundred and three (41.2%) were fed with an adequate frequency for their age. One hundred and ninety-five (78.0%) were given food that was appropriate in consistency for their age. Among 183 (73.2%) children who were not fed appropriately during and after their illness episodes, 119 (65.0%) were malnourished. On using logistic regression it was seen that the variables which had statistically significant association with the complementary feeding patterns (P<0.05) were maternal education, father's age, total members in the family, advice on complementary feeding from health care workers and use of bottle for feeding. Father's education, availability of ration card, antenatal counselling on childcare, birth order and history of repeated illness in the past did not show statistically significant association with complementary feeding practices (P>0.05). Conclusion: There was no statistically significant difference between the feeding patterns of normal and malnourished children. The association of complementary feeding practices and the anthropometric status of study children was not found statistically significant in the present study. Advice on complementary feeding from healthcare workers is seen to be having a positive impact on complementary feeding practices (P < 0.01). [ABSTRACT FROM AUTHOR]

ObjectThis cross-sectional study aims to investigate migraineurs’ preferred complementary and alternative medicine (CAM) types and the factors influencing their usage.Materials and methodsAn anonymous e-survey was distributed to Lithuanian Migraine Association members, and social media migraine support communities. The collected data consisted of demographic, migraine-related questions, personal qualities, CAM habits.Results470 respondents were analyzed. 95.96% were women with a median age of 37 (IQR 31, 44). The median duration of migraine was 17.5 years (IQR 10, 25) and the median headache severity was rated 8 (IQR 7, 10) out of 10. 68.90% of participants had one or more headache days per week. 71.49% of respondents were triptan users, 27.66% used medical prophylaxis, and 17.87% used monoclonal antibodies. 52.55% of respondents used CAM in the past 12 months. Physical activity (36.17%), dietary changes/fasting (27.02%), relaxation/meditation (26.60%) were the most used CAM types. Reasons for CAM use included dissatisfaction with conventional treatment effectiveness (42.51%), concerns about safety (48.18%) and adverse effects (37.25%). Factors associated with the decision to explore CAM included longer headache duration (p = 0.017, Mann–Whitney U test), frequent sick leaves (p

Background: Complementary and alternative medicine (CAM) has emerged to combat the global COVID-19 pandemic. However, no studies have been conducted to evaluate the attitudes, knowledge, and barriers of Chinese clinical and nursing students in implementing CAM during this period. Objective: The aim of this study was to investigate the attitude, knowledge, and barriers of Chinese clinical and nursing students in using CAM in the context of COVID-19. Methods: An online-based cross-sectional survey was carried out among Chinese medical students, majoring in clinical medicine or nursing, in Nanjing, Jiangsu Province, and Zhengzhou, Henan Province from May to July 2022. A total of 402 clinical and 644 nursing students responded to a self-administered questionnaire through the Questionnaire Star and WeChat APPs. SPSS 25 (version 25) was used for data analysis. Proportions were compared by Chi-square test. Level of significance between groups was analyzed using independent student t-test and Mann-Whitney U test. Results: The average score of attitude was 46.63 (SD: 7.38) in clinical students and 49.84 (SD: 6.76) in nursing students. The top four most commonly used CAM treatments in China were proprietary Chinese medicine, diet therapy, decoction, and acupuncture and moxibustion (59.66 %, 22.28 %, 11.66 %, 9.85 %). The students had a good mastery of knowledge about CAM-based prevention and control of COVID-19 (mean score 7.36). The score of CAM knowledge in nursing students was significantly higher than that in clinical students (7.56 VS 7.04, P = 0.000). Gender, grade, previous use, age, and knowledge score could affect students’ attitude towards CAM. The main barriers in spreading CAM use included time-consumption, bad taste, and fear of treatment-related pain (24.5 %). Compared with clinical students, nursing students were more likely to recommend CAM to patients in the future (P = 0.002). Conclusions: During the COVID-19 pandemic, nursing students were more positive towards CAM use, had a better mastery of CAM knowledge than clinical students. CAM is expected to provide better outcomes in COVID-19 patients. Future studies should focus on the changes in students’ attitudes over time and exploration of influencing factors on CAM use.

The outputs of renewable energy sources (RESs) are inherently variable and uncertain, such as wind power (WP) and photovoltaic (PV). However, the outputs of various types of RESs in different regions are complementary. If the capacity of RESs could be properly allocated during system planning, variability of the total output could be reduced. Consequently, system reliability and renewable energy (RE) consumption could be improved. This paper proposes an analytical model for optimal complementary capacity allocation of RESs to decrease variability of the total output. The model considers the capacity ratio of RESs as decision variables and the coefficient of variation (CV) of the total output as the objective function. The proposed approach transforms the single-level optimization model into a bilevel optimization model and derives an analytical equation that can directly calculate the optimal complementary capacity ratio (OCCR) of system RESs. Case studies on wind and solar farms in Xinjiang and Qinghai, China, are performed to verify the effectiveness of the proposed analytical allocation method.

Background: The introduction of complementary food is the most important factor determining the nutritional status of the children in the first 2 years of life. This study aimed to find out the determinants and patterns of complementary feeding practices and their impact on the growth and development of children of 6–24 months of age group. Materials and Methods: A descriptive cross-sectional study was done on immunization out patient department (OPD) in the field practice area of the Department of Community Medicine. The sample size taken was 250 using a systematic random sampling method. Results: One hundred and seven (42.8%) were given the optimum amount of complementary food for their age. One hundred and three (41.2%) were fed with an adequate frequency for their age. One hundred and ninety-five (78.0%) were given food that was appropriate in consistency for their age. Among 183 (73.2%) children who were not fed appropriately during and after their illness episodes, 119 (65.0%) were malnourished. On using logistic regression it was seen that the variables which had statistically significant association with the complementary feeding patterns (P0.05). Conclusion: There was no statistically significant difference between the feeding patterns of normal and malnourished children. The association of complementary feeding practices and the anthropometric status of study children was not found statistically significant in the present study. Advice on complementary feeding from healthcare workers is seen to be having a positive impact on complementary feeding practices (P < 0.01).

This paper proposes a 500 MS/s 4-bit flash analog-to-digital converter (ADC) featuring a differential input voltage range of 1.2 Vpp operating at a supply voltage of 1.2 V. Although the proposed circuit utilizes a conventional flash ADC structure, its track and hold circuit, driving buffer, and preamp circuits corresponding to the analog stages are designed using complementary architecture to attain a sufficient swing range even at a low supply voltage. Notably, the proposed structure satisfies the error requirements. The error source of the flash ADC, such as the comparator’s input referred offset, did not degrade its performance, while the use of a calibration circuit, characterized by power consumption and area burdens and increased complexity, could also be avoided. Therefore, the proposed flash ADC met the error requirements, such as the comparator’s input referred offset, without the need for calibration circuits. The chip, fabricated using the TSMC 65 nm process, covers an area of 1,160 × 950 μm2 and consumes 78 mW of power. Furthermore, its signal-to-noise and distortion ratio and spurious-free dynamic range were measured to be 23.36 dB and 30.26 dB, respectively, at a sampling frequency of 500 MHz.

Broad evolutionary expansion of polymerase families has enabled specialization of their activities for distinct cellular roles. In addition to template-complementary synthesis, many polymerases extend their duplex products by nontemplated nucleotide addition (NTA). This activity is exploited for laboratory strategies of cloning and sequencing nucleic acids and could have important biological function, although the latter has been challenging to test without separation-of-function mutations. Several retroelement and retroviral reverse transcriptases (RTs) support NTA and also template jumping, by which the RT performs continuous complementary DNA (cDNA) synthesis using physically separate templates. Previous studies that aimed to dissect the relationship between NTA and template jumping leave open questions about structural requirements for each activity and their interdependence. Here, we characterize the structural requirements for cDNA synthesis, NTA, template jumping, and the unique terminal transferase activity of Bombyx mori R2 non-long terminal repeat retroelement RT. With sequence alignments and structure modeling to guide mutagenesis, we generated enzyme variants across motifs generally conserved or specific to RT subgroups. Enzyme variants had diverse NTA profiles not correlated with other changes in cDNA synthesis activity or template jumping. Using these enzyme variants and panels of activity assay conditions, we show that template jumping requires NTA. However, template jumping by NTA-deficient enzymes can be rescued using primer duplex with a specific length of 3' overhang. Our findings clarify the relationship between NTA and template jumping as well as additional activities of non-long terminal repeat RTs, with implications for the specialization of RT biological functions and laboratory applications.

Type‐I photosensitizers (PSs) can efficiently generate reactive oxygen species (ROS) in the hypoxia condition of tumors, which show less oxygen dependence and are considered better candidates for photodynamic therapy (PDT). However, relatively few efficient type‐I organic PSs simultaneously generating two or more type‐I ROS under irradiation are reported. Herein, new alternate donor (D)‐acceptor (A) type molecules containing ladder‐type core (DA′D) fused with an electron‐deficient benzothiadiazole core are reported, which show symmetrical A‐DA′D‐A (QY1) and asymmetrical A‐DA′D‐A′′ (QY2) configurations, respectively. As these ROSs possess complementary properties of strong oxidizing ability (•OH) and long radical lifetime (O2•−), in vitro and in vivo experiments demonstrate that QY1 and QY2 show excellent PDT effects for tumor cells under normoxia or hypoxia, and can achieve remarkable tumor growth inhibition (TGI) rate of 90% for the QY2. More importantly, the generation of •OH in these PSs is revealed by experiments both in aqueous and in vitro, including the well‐known transformation of O2•− and direct electron transition from water to excited triplet PS. It thus provides a comprehensive understanding of the O2 dependence property of •OH radical and deep insights into the mechanism of type‐I PS. [ABSTRACT FROM AUTHOR]

Integrative medicine takes a holistic approach because it considers multiple aspects of the individual. This includes a person's physical, emotional, interpersonal, behavioral, nutritional, environmental, and spiritual dimensions of wellbeing that contribute to the Whole Person Health. There is increasing interest and popularity of integrative approaches to treating cognitive decline and dementia because of the multifactorial nature of aging and the limited pharmacological interventions available in treating cognitive decline and dementia, particularly Alzheimer's disease, the most common type of dementia. This review summarizes the existing evidence using complementary and integrative medicine therapies in cognitive decline and Alzheimer's disease. This includes the use of mind-body therapies, lifestyle interventions (nutritional, physical exercise, stress reduction), and other integrative modalities. Unfortunately, there are still limited studies available to guide clinicians despite the increasing popularity of integrative treatments. [ABSTRACT FROM AUTHOR]

This paper explores the concept of "Clip Thinking" in the context of the digital age and investigates whether it is a complimentary or contradictory approach. Clip Thinking refers to the tendency of individuals to consume information and ideas in short, fragmented, and easily digestible formats, often facilitated by social media platforms and digital technologies. While Clip Thinking offers benefits such as quick access to diverse perspectives and efficient information processing, it also raises concerns about shallow engagement, echo chambers, and reduced critical thinking skills. This study employs a mixed-methods approach, combining qualitative interviews and quantitative surveys, to gather insights from participants representing different age groups, educational backgrounds, and digital media consumption habits. The qualitative interviews delve into participants' motivations, habits, and experiences related to Clip Thinking, providing an in-depth understanding of the phenomenon. The quantitative surveys measure participants' information consumption patterns, cognitive abilities, and attitudes towards Clip Thinking. On one hand, participants appreciate the convenience and accessibility offered by short, clipped content. They find it easier to navigate the overwhelming information landscape, rapidly browse topics of interest, and connect with a broader range of ideas. On the other hand, concerns emerge regarding the potential for information overload, reduced attention spans, and a lack of depth in understanding complex issues. Participants express worries about the erosion of critical thinking skills and the creation of filter bubbles that reinforce pre-existing beliefs. By analyzing the data collected, this paper aims to provide a nuanced understanding of the impacts of Clip Thinking on individuals' cognitive processes, decision-making abilities, and overall information consumption habits. The study's conclusions will inform educators, policymakers, and media platforms about the challenges and opportunities associated with promoting a balanced information ecosystem in the digital age. [ABSTRACT FROM AUTHOR]

Background: Naturopathic medicine uses natural and evidence-based treatments to promote health. The objective of this study was to characterize and evaluate the effectiveness of naturopathic medicine in reducing symptoms of anxiety and depression in patients seeking care from the Mental Health Shift at a Canadian naturopathic teaching clinic. Methods: Charts of 192 consecutive patients who attended appointments between 1 January 2019 and 6 March 2020 were reviewed. Subjects were included if they screened positive on the General Anxiety Disorder 7 (GAD7) or the Patient Health Questionnaire 9 (PHQ9) and attended follow up at least 4 weeks after initial treatment. Results: Of the 22 included subjects, a clinically significant decrease of at least 5 points occurred in 76% of individuals with elevated baseline PHQ9 scores and 59% of individuals with elevated GAD7 scores. Mean PHQ9 and GAD7 scores decreased 7.5 (p<0.0001) and 4.6 (p<0.008) points, respectively. Mild adverse events were reported in 9 charts (41%). No serious adverse events were reported. Most subjects were also in the care of a medical doctor and counsellor. Conclusion: Naturopathic medicine as performed on the Mental Health Shift may be effective in reducing depression and anxiety symptoms as an adjunctive treatment. Further research incorporating comparison groups is warranted. [ABSTRACT FROM AUTHOR]

Background: In West Africa, healers greatly outnumber trained mental health professionals. People with serious mental illness (SMI) are often seen by healers in "prayer camps" where they may also experience human rights abuses. We developed "M&M," an 8-week-long dual-pronged intervention involving (1) a smartphone-delivered toolkit designed to expose healers to brief psychosocial interventions and encourage them to preserve human rights (M-Healer app), and (2) a visiting nurse who provides medications to their patients (Mobile Nurse). Objective: We examined the feasibility, acceptability, safety, and preliminary effectiveness of the M&M intervention in real-world prayer camp settings. Methods: We conducted a single-arm field trial of M&M with people with SMI and healers at a prayer camp in Ghana. Healers were provided smartphones with M-Healer installed and were trained by practice facilitators to use the digital toolkit. In parallel, a study nurse visited their prayer camp to administer medications to their patients. Clinical assessors administered study measures to participants with SMI at pretreatment (baseline), midtreatment (4 weeks) and post treatment (8 weeks). Results: Seventeen participants were enrolled and most (n=15, 88.3%) were retained. Participants had an average age of 44.3 (SD 13.9) years and 59% (n=10) of them were male. Fourteen (82%) participants had a diagnosis of schizophrenia and 2 (18%) were diagnosed with bipolar disorder. Four healers were trained to use M-Healer. On average, they self-initiated app use 31.9 (SD 28.9) times per week. Healers watched an average of 19.1 (SD 21.2) videos, responded to 1.5 (SD 2.4) prompts, and used the app for 5.3 (SD 2.7) days weekly. Pre-post analyses revealed a significant and clinically meaningful reduction in psychiatric symptom severity (Brief Psychiatric Rating Scale score range 52.3 to 30.9; Brief Symptom Inventory score range 76.4 to 27.9), psychological distress (Talbieh Brief Distress Inventory score range 37.7 to 16.9), shame (Other as Shamer Scale score range 41.9 to 28.5), and stigma (Brief Internalized Stigma of Mental Illness Scale score range 11.8 to 10.3). We recorded a significant reduction in days chained (1.6 to 0.5) and a promising trend for reduction in the days of forced fasting (2.6 to 0.0, P=.06). We did not identify significant pre-post changes in patient-reported working alliance with healers (Working Alliance Inventory), depressive symptom severity (Patient Health Questionnaire-9), quality of life (Lehman Quality of Life Interview for the Mentally Ill), beliefs about medication (Beliefs about Medications Questionnaire--General Harm subscale), or other human rights abuses. No major side effects, health and safety violations, or serious adverse events occurred over the course of the trial. Conclusions: The M&M intervention proved to be feasible, acceptable, safe, and clinically promising. Preliminary findings suggest that the M-Healer toolkit may have shifted healers' behaviors at the prayer camp so that they commit fewer human rights abuses. [ABSTRACT FROM AUTHOR]

An experiment was conducted on ridge gourd in six generations i.e., P1, P2, F1, F2, BC1 and BC2 of VRG-24 x VRG-13 and Swarna Manjari x Arka Prasan in Randomized Block Design with three replications. The main aim of the study was to investigate the genetic mechanisms controlling yield and quality traits through generation mean analysis. Epistatic gene effects were found to play a crucial role in regulating most of the traits studied, except for days to male flowering, days to female flowering, node of first female flower, average fruit weight, and rind thickness in various crosses. Duplicate epistasis was particularly prominent across the majority of traits, suggesting that these traits could be effectively exploited through heterosis breeding and reciprocal recurrent selection strategies. Additionally, complementary epistasis was observed in the cross VRG-24 x VRG-13 for traits such as node of first female flower, number of female flowers per vine, and number of fruits per vine. This highlights the potential of the VRG-24 x VRG-13 cross to produce desirable transgressive segregants with enhanced trait combinations. [ABSTRACT FROM AUTHOR]

Objective: Since placebo and nocebo-responses during acupuncture therapy are rarely studied in clinical contexts, the objective was to investigate placebo and nocebo-responses in a clinical context through comparing positive and negative side-effects between genuine and sham acupuncture, and to identify factors modifying placebo and nocebo-responses. Methods: Patients reported positive side-effects (non-intended positive effects) or negative side-effects (non-intended negative effects) of genuine (penetrating; n = 109) or sham (telescopic non-penetrating; n = 106) acupuncture during 5 weeks of chemoradiation for cancer. Results: The genuine and the sham acupuncture group reported rather similar frequencies of positive (P -values.223-.800) or negative (P -values.072-1.0) side-effects: relaxation 59%/57% of the patients, improved mood 46%/38%, improved sleep 38%/38%, pain-reduction 36%/28%, tiredness 42%/42%, feeling cold 37%/31%, sweating 23%/21%, and dizziness 20%/12%. Positive side-effects occurred in 79% of patients who highly believed acupuncture to be effective, compared to in 0% of patients who did not believe. Other factors associated with placebo-response were female sex (P =.042), anxious mood (P =.007), depressed mood (P =.018), and blinding-success (P =.033). Factors associated with nocebo response were female sex (P =.049), younger age (P =.010), and needle-induced pain (P =.014). Sham-treated patients experiencing positive side-effects experienced better quality of life at the end of the treatment period (mean, m 64 on a scale 0-100 millimetres, Standard Deviation, SD, ±26.1 mm) than those who did not (m 48 ± 25.5 mm), P =.048 (adjusted for other characteristics). Conclusions: Clinically significant levels of placebo and nocebo effects commonly occurred during acupuncture therapy in integrative cancer care and this paper identified factors modifying these responses. This implicates that acupuncture-delivering therapists striving to maximize placebo-responses and minimize nocebo-responses may considering strengthen the patient's treatment expectations, and offer a pleasant, pain-free, acupuncture treatment. [ABSTRACT FROM AUTHOR]

This article provides a comprehensive systematic review and qualitative analysis of the current research investigating Ayurveda chronic rhinosinusitis (CRS) treatment. PRISMA guidelines for systematic reviews was followed and our search utilized MEDLINE, Embase, Ayush Portal, and Cochrane Library databases. Articles published prior to March 2022, 10 or more patients that investigated Ayurveda as a treatment for CRS in humans were included. This resulted in thirteen articles meeting inclusion criteria. Ayurvedic treatments included herbal medications for oral consumption, nasal instillation, and steam inhalation used alone or in combination. All studies concluded that Ayurvedic therapy led to improvements in subjective CRS symptoms and objective radiographic and hematologic criteria. However, all 13 studies had a significant risk of bias due to study design and statistical methods utilized. Ayurvedic therapy may be a useful CRS treatment for some patients and overall appears to be well tolerated. However, definitive recommendation for when Ayurvedic treatments would be beneficial in the treatment of CRS remains not possible. Given the overall positive effects shown in the current published evidence and growing interest in complementary and integrative therapies, Ayurvedic treatments for CRS deserve further investigation in the form of well-designed controlled trials. [ABSTRACT FROM AUTHOR]

Epistemic akrasia describes a non-ideal situation in which an agent holds a belief like, “P, but my evidence does not support P.” It is controversial whether it is possible or rational to hold such an akratic belief. In this paper, I attempt to explain akratic beliefs in terms of an updated notion of yin and yang in Chinese philosophy. Epistemologists evaluate akratic beliefs as if they are the end of an inquiry or inference. Drawing from the updated notion of yin/yang in which yin is conceived as receptivity and yang is conceived as direct purpose (or impulsion), an akratic belief is shown to be an unstable, intermediate temporal belief state in the middle of the entire process. It is not the end result, rather, it is a transitional episode of an inquiry or inference in progress. Hence, it is the entire process to be evaluated rather than the temporal belief state in the middle of the process. Given this notion of yin/yang, an akratic belief illustrates that an agent is open-minded in the sense that she is receptive to evidence, which motivates her to proceed through further investigation. Ultimately, the socalled akratic beliefs are segments of a diachronic process of belief concatenation. [ABSTRACT FROM AUTHOR]

Recent multi-domain processing methods have demonstrated promising performance for monaural speech enhancement tasks. However, few of them explain why they behave better over single-domain approaches. As an attempt to fill this gap, this paper presents a complementary single-channel speech enhancement network (CompNet) that demonstrates promising denoising capabilities and provides a unique perspective to understand the improvements introduced by multi-domain processing. Specifically, the noisy speech is initially enhanced through a time-domain network. However, despite the waveform can be feasibly recovered, the distribution of the time–frequency bins may still be partly different from the target spectrum when we reconsider the problem in the frequency domain. To solve this problem, we design a dedicated dual-path network as a post-processing module to independently filter the magnitude and refine the phase. This further drives the estimated spectrum to closely approximate the target spectrum in the time–frequency domain. We conduct extensive experiments with the WSJ0-SI84 and VoiceBank + Demand datasets. Objective test results show that the performance of the proposed system is highly competitive with existing systems. [ABSTRACT FROM AUTHOR]

To treat the impact of trauma, most current evidence supports the use of trauma-focused psychotherapy as the first line approach. However, millions of individuals exposed to trauma worldwide seek Complementary and Integrative Health (CIH) therapies in hopes of achieving wellness above and beyond reducing symptoms. But what is the evidence for CIH interventions? What are potential pitfalls? Given the growing popularity of and strong interest in CIH, EJPT is featuring research on these approaches in this special issue. The papers range from common interventions such as mindfulness to the use of service dogs and scuba diving to alleviate trauma related symptoms. A featured editorial highlights the importance of defining when, where, and how placebo responses work. Nonspecific elements of treatment such as positive expectations, therapeutic rituals, healing symbols, and social interactions are identified as factors influencing treatment response and scientists looking to add to the CIH evidence base are encouraged to consider the impact and methodological challenges these elements present. CIH interventions more specifically recognize and harness some of these factors in addition to intervention-specific factors such as attention or emotion regulation along with focus on overall wellbeing. The body of work in this special issue supports the emerging evidence for meditative and relaxation-based interventions and illustrates a creative but nascent state of the field. Cross-intervention mechanisms that may play a role in achieving wellness, such as arousal reduction, emotion regulation, posttraumatic growth, and positive affect are highlighted. The trauma field would benefit from accumulation of evidence for promising CIH interventions, evaluation of potential mechanisms, and examination of health and wellbeing outcomes. With the paucity of high-quality trials, it would be premature to recommend CIH interventions as first-line treatments. However, the emerging literature on CIH continues to advance our understanding of what works and how these interventions exert their effects. Complementary and Integrative Health (CIH) interventions for trauma that target holistic wellness above and beyond symptom reduction are increasingly used in the real world, though the evidence base lags. Papers in this issue support the emerging evidence for efficacy of mindfulness or other meditative or relaxation-based interventions. This special issue illustrates creative approaches but also the need for continued research establishing efficacy, evaluating more inclusive outcomes (e.g. a sense of wellbeing or ability to pursue valued life goals), and identifying potential mechanisms. [ABSTRACT FROM AUTHOR]