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3 results on '"COLD-CE"'

1. Adrenaline autoinjector is underprescribed in typical cold urticaria patients.

Author

Bizjak, Mojca, Košnik, Mitja, Dinevski, Dejan, Thomsen, Simon Francis, Fomina, Daria, Borzova, Elena, Kulthanan, Kanokvalai, Meshkova, Raisa, Aarestrup, Fernando Monteiro, Ahsan, Dalia Melina, Al‐Ahmad, Mona, Altrichter, Sabine, Bauer, Andrea, Brockstädt, Maxi, Costa, Célia, Demir, Semra, Criado, Roberta Fachini, Ensina, Luis Felipe, Gelincik, Asli, and Giménez‐Arnau, Ana Maria

Subjects
*URTICARIA, *ADRENALINE, *MEDICAL personnel
Abstract

Keywords: adrenaline autoinjector; cold urticaria; COLD-CE; cold-induced anaphylaxis EN adrenaline autoinjector cold urticaria COLD-CE cold-induced anaphylaxis 2224 2229 6 07/04/22 20220701 NES 220701 ACKNOWLEDGMENT This manuscript benefited from the support of the GA SP 2 sp LEN UCARE network (www.ga2len-ucare.com). 5 a Any cold trigger (i.e., complete cold water immersion, cold ambient air exposure, transition from cold outdoors to warm indoors, localized contact with cold liquids without immersion or ice, and contact with cold surfaces). [Extracted from the article]

Published
2022
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2. Risk factors for systemic reactions in typical cold urticaria: Results from the COLD‐CE study.

Author

Bizjak, Mojca, Košnik, Mitja, Dinevski, Dejan, Thomsen, Simon Francis, Fomina, Daria, Borzova, Elena, Kulthanan, Kanokvalai, Meshkova, Raisa, Ahsan, Dalia Melina, Al‐Ahmad, Mona, Altrichter, Sabine, Bauer, Andrea, Brockstädt, Maxi, Costa, Célia, Demir, Semra, Fachini Criado, Roberta, Ensina, Luis Felipe, Gelincik, Asli, Giménez‐Arnau, Ana Maria, and Gonçalo, Margarida

Subjects
*URTICARIA, *CARDIOLOGICAL manifestations of general diseases, *SYMPTOMS, *WATER immersion, *MUCOUS membranes, *CARDIOVASCULAR diseases risk factors
Abstract

Background: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold‐induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods: An international, cross‐sectional study COLD‐CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold‐induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold‐induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p =.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion: ColdA is common in typical ColdU. High‐risk patients require education about their condition and how to use an adrenaline autoinjector. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Risk factors for systemic reactions in typical cold urticaria:Results from the COLD-CE study

Author

Bizjak, Mojca, Košnik, Mitja, Dinevski, Dejan, Thomsen, Simon Francis, Fomina, Daria, Borzova, Elena, Kulthanan, Kanokvalai, Meshkova, Raisa, Ahsan, Dalia Melina, Al-Ahmad, Mona, Altrichter, Sabine, Bauer, Andrea, Brockstädt, Maxi, Costa, Célia, Demir, Semra, Fachini Criado, Roberta, Ensina, Luis Felipe, Gelincik, Asli, Giménez-Arnau, Ana Maria, Gonçalo, Margarida, Gotua, Maia, Holm, Jesper Grønlund, Inomata, Naoko, Kasperska-Zajac, Alicja, Khoshkhui, Maryam, Klyucharova, Aliya, Kocatürk, Emek, Lu, Rongbiao, Makris, Michael, Maltseva, Natalya, Miljković, Jovan, Pasali, Maria, Paulino, Marisa, Pesqué, David, Peter, Jonny, Ramón, German Dario, Ritchie, Carla, Rodrigues Valle, Solange Oliveira, Rudenko, Michael, Sikora, Agnieszka, de Souza Lima, Eduardo M., Wagner, Nicola, Xepapadaki, Paraskevi, Xue, Xiaoyang, Zhao, Zuotao, Terhorst-Molawi, Dorothea, Maurer, Marcus, Bizjak, Mojca, Košnik, Mitja, Dinevski, Dejan, Thomsen, Simon Francis, Fomina, Daria, Borzova, Elena, Kulthanan, Kanokvalai, Meshkova, Raisa, Ahsan, Dalia Melina, Al-Ahmad, Mona, Altrichter, Sabine, Bauer, Andrea, Brockstädt, Maxi, Costa, Célia, Demir, Semra, Fachini Criado, Roberta, Ensina, Luis Felipe, Gelincik, Asli, Giménez-Arnau, Ana Maria, Gonçalo, Margarida, Gotua, Maia, Holm, Jesper Grønlund, Inomata, Naoko, Kasperska-Zajac, Alicja, Khoshkhui, Maryam, Klyucharova, Aliya, Kocatürk, Emek, Lu, Rongbiao, Makris, Michael, Maltseva, Natalya, Miljković, Jovan, Pasali, Maria, Paulino, Marisa, Pesqué, David, Peter, Jonny, Ramón, German Dario, Ritchie, Carla, Rodrigues Valle, Solange Oliveira, Rudenko, Michael, Sikora, Agnieszka, de Souza Lima, Eduardo M., Wagner, Nicola, Xepapadaki, Paraskevi, Xue, Xiaoyang, Zhao, Zuotao, Terhorst-Molawi, Dorothea, and Maurer, Marcus

Abstract

Background: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods: An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p =.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion: ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.

Published
2022

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