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Chinese Clinical Named Entity Recognition (CNER) is a crucial step in extracting medical information and is of great significance in promoting medical informatization. However, CNER poses challenges due to the specificity of clinical terminology, the complexity of Chinese text semantics, and the uncertainty of Chinese entity boundaries. To address these issues, we propose an improved CNER model, which is based on multi-feature fusion and multi-scale local context enhancement. The model simultaneously fuses multi-feature representations of pinyin, radical, Part of Speech (POS), word boundary with BERT deep contextual representations to enhance the semantic representation of text for more effective entity recognition. Furthermore, to address the model's limitation of focusing just on global features, we incorporate Convolutional Neural Networks (CNNs) with various kernel sizes to capture multi-scale local features of the text and enhance the model's comprehension of the text. Finally, we integrate the obtained global and local features, and employ multi-head attention mechanism (MHA) extraction to enhance the model's focus on characters associated with medical entities, hence boosting the model's performance. We obtained 92.74%, and 87.80% F1 scores on the two CNER benchmark datasets, CCKS2017 and CCKS2019, respectively. The results demonstrate that our model outperforms the latest models in CNER, showcasing its outstanding overall performance. It can be seen that the CNER model proposed in this study has an important application value in constructing clinical medical knowledge graph and intelligent Q&A system. [ABSTRACT FROM AUTHOR]

Abstract Motivation Application of chemical named entity recognition (CNER) algorithms allows retrieval of information from texts about chemical compound identifiers and creates associations with physical–chemical properties and biological activities. Scientific texts represent low-formalized sources of information. Most methods aimed at CNER are based on machine learning approaches, including conditional random fields and deep neural networks. In general, most machine learning approaches require either vector or sparse word representation of texts. Chemical named entities (CNEs) constitute only a small fraction of the whole text, and the datasets used for training are highly imbalanced. Methods and results We propose a new method for extracting CNEs from texts based on the naïve Bayes classifier combined with specially developed filters. In contrast to the earlier developed CNER methods, our approach uses the representation of the data as a set of fragments of text (FoTs) with the subsequent preparati`on of a set of multi-n-grams (sequences from one to n symbols) for each FoT. Our approach may provide the recognition of novel CNEs. For CHEMDNER corpus, the values of the sensitivity (recall) was 0.95, precision was 0.74, specificity was 0.88, and balanced accuracy was 0.92 based on five-fold cross validation. We applied the developed algorithm to the extracted CNEs of potential Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors. A set of CNEs corresponding to the chemical substances evaluated in the biochemical assays used for the discovery of Mpro inhibitors was retrieved. Manual analysis of the appropriate texts showed that CNEs of potential SARS-CoV-2 Mpro inhibitors were successfully identified by our method. Conclusion The obtained results show that the proposed method can be used for filtering out words that are not related to CNEs; therefore, it can be successfully applied to the extraction of CNEs for the purposes of cheminformatics and medicinal chemistry.

Motivation: Application of chemical named entity recognition (CNER) algorithms allows retrieval of information from texts about chemical compound identifiers and creates associations with physical–chemical properties and biological activities. Scientific texts represent low-formalized sources of information. Most methods aimed at CNER are based on machine learning approaches, including conditional random fields and deep neural networks. In general, most machine learning approaches require either vector or sparse word representation of texts. Chemical named entities (CNEs) constitute only a small fraction of the whole text, and the datasets used for training are highly imbalanced. Methods and results: We propose a new method for extracting CNEs from texts based on the naïve Bayes classifier combined with specially developed filters. In contrast to the earlier developed CNER methods, our approach uses the representation of the data as a set of fragments of text (FoTs) with the subsequent preparati'on of a set of multi-n-grams (sequences from one to n symbols) for each FoT. Our approach may provide the recognition of novel CNEs. For CHEMDNER corpus, the values of the sensitivity (recall) was 0.95, precision was 0.74, specificity was 0.88, and balanced accuracy was 0.92 based on five-fold cross validation. We applied the developed algorithm to the extracted CNEs of potential Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors. A set of CNEs corresponding to the chemical substances evaluated in the biochemical assays used for the discovery of Mpro inhibitors was retrieved. Manual analysis of the appropriate texts showed that CNEs of potential SARS-CoV-2 Mpro inhibitors were successfully identified by our method. Conclusion: The obtained results show that the proposed method can be used for filtering out words that are not related to CNEs; therefore, it can be successfully applied to the extraction of CNEs for the purposes of cheminformatics and medicinal chemistry. [ABSTRACT FROM AUTHOR]

Pesquisamos a Revista da Campanha Nacional de Educação Rural (RCNER) para compreender o papel atribuído às enfermeiras no desenvolvimento da Campanha Nacional de Educação Rural (CNER), realizada no Brasil de 1952 a 1963. Os objetivos da pesquisa consistiram em: perscrutar os critérios adotados pela campanha para recrutar e treinar as enfermeiras e compreender se o trabalho dessas profissionais contribuiu para melhorar a qualidade de vida da população rural.

The huge space of experimental data on biological and chemical objects and their interactions contributes to the rapid growth of scientific publications containing their analysis. Such data may include characteristics of low-molecular-weight compounds, results of their biological activity evaluation, and their interaction with human and animal proteins, methods of synthesis of organic compounds, and their classification. The past decades saw the development of methods for automated extraction of data from texts of scientific publications, including those for retrieval of names of organic compounds. These data can be used for the automatic identification of the names of organic compounds, including all possible synonyms. Since the topics of scientific publications are diverse, the extracted data can be applied to obtain information about (1) classification of organic compounds (2) methods of synthesis of a given organic compound; (3) physicochemical properties of this compound; (4) its interaction with high-molecular-weight compounds (including proteins, mRNA of animals and humans); and (5) the therapeutic properties of organic compounds, the active substance of the drug, and data on clinical trials. This review considers the methods aimed at searching and extracting data on names of low-molecular-weight compounds and interactions between them and animal and human proteins (biological objects), as well as data on experimentally confirmed biological activity and the effects of organic compounds (including drugs) on pathological processes. Here, we discuss the methods developed and the results of their application published over the past 10 years. [ABSTRACT FROM AUTHOR]