1. The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis
- Author
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Mathieu Boissan, Malgorzata Tokarska-Schlattner, Marie-Lise Lacombe, Uwe Schlattner, Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Fondation pour la Recherche Médicale (FRM, DPM20121125557), Groupement des Entreprises Françaises contre le Cancer (GEFLUC), Cancéropôle IdF (n° 2015-1-EMERG-25-INSERM 6-1), and CMIRA Explo’ra - Région Rhone Alpes
- Subjects
0301 basic medicine ,Protein moonlighting ,Cell ,Apoptosis ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Mitochondrion ,Pathology and Forensic Medicine ,03 medical and health sciences ,Neoplasms ,Mitophagy ,medicine ,Animals ,Homeostasis ,Humans ,Molecular Biology ,Gene ,Phospholipids ,ComputingMilieux_MISCELLANEOUS ,Chemistry ,Kinase ,Nucleoside Diphosphate Kinase D ,Cell Biology ,Nucleoside-diphosphate kinase ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure - Abstract
Mitochondrial nucleoside diphosphate kinase (NDPK-D; synonyms: NME4, NM23-H4) represents the major mitochondrial NDP kinase. The homohexameric complex emerged as a protein with multiple functions in bioenergetics and phospholipid signaling. It occurs at different but precise mitochondrial locations and can affect among other mitochondrial shapes and dynamics, as well as the specific elimination of defective mitochondria or cells via mitophagy or apoptosis. With these various functions in cell homeostasis, NDPK-D/NME4 adds to the group of so-called moonlighting (or gene sharing) proteins.
- Published
- 2018
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