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21 results on '"CLERICI Libero"'

1. Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM-ICCVAM/NICEATM Considerations for Regulatory Use

Author

Corvi, Raffaella, Ahr, Hans-Jürgen, Albertini, Silvio, Blakey, David H., Clerici, Libero, Coecke, Sandra, Douglas, George R., Gribaldo, Laura, Groten, John P., Haase, Bernd, Hamernik, Karen, Hartung, Thomas, Inoue, Tohru, Indans, Ian, Maurici, Daniela, Orphanides, George, Rembges, Diana, Sansone, Susanna-Assunta, Snape, Jason R., Toda, Eisaku, Tong, Weida, van Delft, Joost H., Weis, Brenda, and Schechtman, Leonard M.

Published
2006

6. Validation of Toxicogenomics-Based Test Systems:ECVAM-ICCVAM/NICEATM Considerations for Regulatory Use

Author

CORVI RAFFAELLA, AHR Hans, ALBERTINI Silvio, BLAKEY David, CLERICI Libero, COECKE SANDRA, DOUGLAS George, GRIBALDO LAURA, GROTEN John, HAASE Bernd, HAMERNIK Karen, HARTUNG THOMAS, INOUE Tohru, INDANS Ian, MAURICI Daniela, ORPHANIDES George, REMBGES DIANA, SANSONE Susanna, SNAPE Jason, TODA Eisaku, TONG Weida, VAN DELFT Joost, WEIS Brenda, and SCHECHTMAN Leonard

Abstract

This is the report of the first workshop on the Validation of Toxicogenomics-based Test Systems held in Ispra, Italy on 11-12 December 2003. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The primary aim of the workshop was to discuss and define principles applicable to the validation of toxicogenomics platforms as well as validation of specific toxicological test methods that incorporate toxicogenomics technologies. The workshop was viewed as an opportunity for initiating a dialogue between technological experts, regulators, and the principal validation bodies, and for identifying those factors to which the validation process would be applicable. It was felt that to do so now, as the technology is evolving and associated challenges are identified, would serve as the basis for the future validation of the technology when it reached the appropriate stage. Due to the complexity of the issue, different aspects of the validation of toxicogenomics-based test methods were covered. The three focus areas included (a) biological validation of toxicogenomics-based test methods for regulatory decision-making, (b) technical and bioinformatics aspects related to validation, and (c) validation issues as they relate to regulatory acceptance and utilization of toxicogenomics-based test methods. This report summarizes the discussions and details the recommendations for future direction and priorities., JRC.I.2-Validation of biomedical testing methods

Published
2005

10. Early and multifocal tumors in breast, salivary, Harderian and epididymal tissues developed in MMTY-Neu transgenic mice

Author

Lucchini, Franco, primary, Sacco, Maria Grazia, additional, Hu, Nanpin, additional, Villa, Anna, additional, Brown, John, additional, Cesano, Luigi, additional, Mangiarini, Laura, additional, Rindi, Guido, additional, Kindl, Sandra, additional, Sessa, Fausto, additional, Vezzoni, Paolo, additional, and Clerici, Libero, additional

Published
1992
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13. The Toxicity of Tritium: The Effects of Tritiated Amino-acids on Preimplanted Mouse Embryos

Author

Clerici, Libero, Carroll, Michael, Merlini, Margaret, Vercellini, Luisa, and Campagnari, Francesco

Abstract

The effects of tritiated amino-acids, arginine, lysine, histidine and aspartic acid on the growth and development of two-cell mouse embryos, cultured in vitro, were investigated. The LD50 for the dibasic amino acids, measured on the third day of growth, ranged from 30 to 130 nCi/ml. This was compared with the DNA precursor, thymidine, for which the LD50 was 80 nCi/ml.

Published
1984
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14. Poly(A) Polymerase Distribution in Normal and Malignant Lymphoid Cells

Author

Lucchini, Roberto, Vezzoni, Paolo, Giardini, Roberto, Vezzoni, Maria A., Raineri, Monica, and Clerici, Libero

Abstract

The incorporation of ATP on poly(A) primers catalyzed by poly(A) polymerase was investigated in normal and neoplastic lymphoid cells from animal and human sources. High levels of the enzyme were found in mouse thymus, in chicken bursa and thymus, as well as in neoplastic cells from patients affected by lymphoblastic and Burkitt's lymphomas. Low or very low quantities were found in peripheral blood lymphocytes, chronic lymphocytic leukemia cells, normal lymph nodes and solid lymphoid tissues of Hodgkin's disease. In general, the enzymatic content of neoplastic lymphoid cells reflected those of their normal counterpart. No effect of fasting or cortisone treatment on poly(A) polymerase in mouse spleen, thymus or liver was found. No particular relationships with B, T or non-T, non-B lineages were observed, but some relationship with DNA polymerase alpha was found. Therefore, it may be that poly(A) polymerase levels are related to the proliferative activity of the cellular populations.

Published
1984
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15. Alkaline Phosphatase and Gamma Glutamyltranspeptidase in Human Lymphomas

Author

Spinazzè, Silvia, Vezzoni, M. Antonietta, Murone, Michelangelo, Banfi, Emanuela, Giardini, Roberto, Stangalini, Alberto, Clerici, Libero, Scanni, Alberto, and Vezzoni, Paolo

Abstract

Alkaline phosphatase (AP) and gamma glutamyltranspeptidase (GGT) were studied in normal lymphoid cells and in 28 cases of human lymphomas (23 of non-Hodgkin's and 5 of Hodgkin's disease). The expression of AP was enhanced in several samples with a high proportion of mature B cells, particularly in centroblastic-centrocytic lymphoma, whereas tissues mainly composed of T cells always showed low levels of this enzyme. GGT levels were high in thymus, as well as in centroblastic-centrocytic lymphoma and other NHL, thus demonstrating no restriction to a particular cell lineage. Some B-cell neoplasms with cellular origin different from that of centroblastic-centrocytic lymphoma, such as chronic lymphocytic leukemia and centrocytic lymphoma, had low levels of both enzymes. The role of investigation with specific antibodies against these two enzymatic activities in the physiology of lymphoma cell membrane is discussed.

Published
1986
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